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2. Prevalence of Fabry disease and GLA variants in young patients with acute stroke: The challenge to widen the screening. The Fabry-Stroke Italian Registry

Author

Romani, Ilaria, Sarti, Cristina, Nencini, Patrizia, Pracucci, Giovanni, Zedde, Marialuisa, Cianci, Vittoria, Nucera, Antonia, Moller, Jessica, Orsucci, Daniele, Toni, Danilo, Palumbo, Pasquale, Casella, Carmela, Pinto, Vincenza, Barbarini, Leonardo, Bella, Rita, Scoditti, Umberto, Ragno, Michele, Mezzapesa, Domenico Maria, Tassi, Rossana, Volpi, Gino, Diomedi, Marina, Bigliardi, Guido, Cavallini, Anna Maria, Chiti, Alberto, Ricci, Stefano, Cecconi, Emanuela, Linoli, Giovanni, Sacco, Simona, Rasura, Maurizia, Giordano, Antonello, Bonetti, Bruno, Melis, Marta, Cariddi, Lucia Princiotta, Dossi, Roberto Currò, Grisendi, Ilaria, Aguglia, Umberto, Di Ruzza, Maria Rita, Melis, Maurizio, Sbardella, Emilia, Vista, Marco, Valenti, Raffaella, Musolino, Rosa Fortunata, Passarella, Bruno, Direnzo, Vita, Pennisi, Giovanni, Genovese, Antonio, Di Marzio, Fabio, Sgobio, Rossana, Acampa, Maurizio, Nannucci, Serena, Dagostino, Federica, Dell'Acqua, Maria Luisa, Cuzzoni, Maria Giovanna, Picchioni, Antonella, Calchetti, Benedetta, Notturno, Francesca, Di Lisi, Filomena, Forlivesi, Stefano, Delodovici, Maria Luisa, Buechner, Susanne Christiane, Biagini, Silvia, Accavone, Donatella, Manna, Raffaele, Morrone, Amelia, and Inzitari, Domenico

Published
2024
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5. Platelet Function Monitoring Performed after Carotid Stenting during Endovascular Stroke Treatment Predicts Outcome

Author

Ciolli, Ludovico, Lelli, Nicoletta, Rosafio, Francesca, Maffei, Stefania, Sacchetti, Federico, Vandelli, Laura, Dell'Acqua, Maria Luisa, Picchetto, Livio, Borzì, Giuseppe Maria, Ricceri, Riccardo, Pentore, Roberta, Tondelli, Manuela, Vandelli, Gabriele, Rodríguez-Villatoro, Noelia, Meletti, Stefano, Zini, Andrea, Vallone, Stefano, and Bigliardi, Guido

Published
2021
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12. Fibrinogen Depletion Coagulopathy Predicts Major Bleeding After Thrombolysis for Ischemic Stroke: A Multicenter Study.

Author

Romoli, Michele, Vandelli, Laura, Bigliardi, Guido, Naccarato, Marcello, Moller, Jessica, Balestrino, Maurizio, Giammello, Fabrizio, Gentile, Mauro, Dell’Acqua, Maria Luisa, Manganotti, Paolo, Forlivesi, Stefano, Melis, Maurizio, Picchetto, Livio, Rosafio, Francesca, Furlanis, Giovanni, Testoni, Stefania, Piras, Valeria, Malfatto, Laura, Musolino, Rosa Fortunata, and Scali, Ilario

Published
2023
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13. Intravenous Thrombolysis in Patients With Ischemic Stroke Aged ≥90 Years: A Cohort Study From the TRISP Collaboration.

Author

Altersberger, Valerian L., Rusche, Norman, Martinez-Majander, Nicolas, Hametner, Christian, Scheitz, Jan F., Henon, Hilde, Dell’Acqua, Maria Luisa, Strambo, Davide, Stolp, Jeffrey, Heldner, Mirjam R., Grisendi, Ilaria, Jovanovic, Dejana R., Bejot, Yannick, Pezzini, Alessandro, Leker, Ronen R., Kägi, Georg, Wegener, Susanne, Cereda, Carlo W., Lindgren, Erik, and Ntaios, George

Published
2023
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14. Intracranial Stenosis Treated with Stenting in Patients with Suspected Cerebral Vasculitis: Two Case Reports

Author

Vandelli, Gabriele, primary, Giacobazzi, Laura, additional, Ciolli, Ludovico, additional, Dell'Acqua, Maria Luisa, additional, Vandelli, Laura, additional, Picchetto, Livio, additional, Rosafio, Francesca, additional, Borzì, Giuseppe Maria, additional, Ricceri, Riccardo, additional, Meletti, Stefano, additional, Vallone, Stefano, additional, Salvarani, Carlo, additional, Sebastiani, Marco, additional, Sacchetti, Federico, additional, Verganti, Luca, additional, Merolla, Stefano, additional, Zelent, Gabriele, additional, and Bigliardi, Guido, additional

Published
2023
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15. Fibrinogen Depletion Coagulopathy Predicts Major Bleeding After Thrombolysis for Ischemic Stroke: A Multicenter Study

Author

Romoli, Michele, primary, Vandelli, Laura, additional, Bigliardi, Guido, additional, Naccarato, Marcello, additional, Moller, Jessica, additional, Balestrino, Maurizio, additional, Giammello, Fabrizio, additional, Gentile, Mauro, additional, Dell’Acqua, Maria Luisa, additional, Manganotti, Paolo, additional, Forlivesi, Stefano, additional, Melis, Maurizio, additional, Picchetto, Livio, additional, Rosafio, Francesca, additional, Furlanis, Giovanni, additional, Testoni, Stefania, additional, Piras, Valeria, additional, Malfatto, Laura, additional, Musolino, Rosa Fortunata, additional, Scali, Ilario, additional, Maffei, Stefania, additional, Migliaccio, Ludovica, additional, Trenti, Tommaso, additional, Mancini, Rita, additional, Marietta, Marco, additional, Randi, Vanda, additional, Meletti, Stefano, additional, and Zini, Andrea, additional

Published
2022
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17. The role of automated computed topography perfusion in prediction of hemorrhagic transformation after acute ischemic stroke

Author

Elsaid, Nada, primary, Bigliardi, Guido, additional, Dell’Acqua, Maria Luisa, additional, Vandelli, Laura, additional, Ciolli, Ludovico, additional, Picchetto, Livio, additional, Borzì, Giuseppe, additional, Ricceri, Riccardo, additional, Pentore, Roberta, additional, Vallone, Stefano, additional, Meletti, Stefano, additional, and Saied, Ahmed, additional

Published
2022
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19. Intravenous thrombolysis or endovascular therapy for acute ischemic stroke associated with cervical internal carotid artery occlusion: the ICARO-3 study

Author

Paciaroni, Maurizio, Inzitari, Domenico, Agnelli, Giancarlo, Caso, Valeria, Balucani, Clotilde, Grotta, James C., Sarraj, Amrou, Sung-Il, Sohn, Chamorro, Angel, Urra, Xabier, Leys, Didier, Henon, Hilde, Cordonnier, Charlotte, Dequatre, Nelly, Aguettaz, Pierre, Alberti, Andrea, Venti, Michele, Acciarresi, Monica, D’Amore, Cataldo, Zini, Andrea, Vallone, Stefano, Dell’Acqua, Maria Luisa, Menetti, Federico, Nencini, Patrizia, Mangiafico, Salvatore, Barlinn, Kristian, Kepplinger, Jessica, Bodechtel, Ulf, Gerber, Johannes, Bovi, Paolo, Cappellari, Manuel, Linfante, Italo, Dabus, Guilherme, Marcheselli, Simona, Pezzini, Alessandro, Padovani, Alessandro, Alexandrov, Andrei V., Shahripour, Reza Bavarsad, Sessa, Maria, Giacalone, Giacomo, Silvestrelli, Giorgio, Lanari, Alessia, Ciccone, Alfonso, De Vito, Alessandro, Azzini, Cristiano, Saletti, Andrea, Fainardi, Enrico, Orlandi, Giovanni, Chiti, Alberto, Gialdini, Gino, Silvestrini, Mauro, Ferrarese, Carlo, Beretta, Simone, Tassi, Rossana, Martini, Giuseppe, Tsivgoulis, Georgios, Vasdekis, Spyros N., Consoli, Domenico, Baldi, Antonio, D’Anna, Sebastiano, Luda, Emilio, Varbella, Ferdinando, Galletti, Giampiero, Invernizzi, Paolo, Donati, Edoardo, De Lodovici, Maria Luisa, Bono, Giorgio, Corea, Francesco, Sette, Massimo Del, Monaco, Serena, Riva, Maurizio, Tassinari, Tiziana, Scoditti, Umberto, and Toni, Danilo

Published
2015
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20. Risk Profile of Symptomatic Lacunar Stroke Versus Nonlobar Intracerebral Hemorrhage

Author

Morotti, Andrea, Paciaroni, Maurizio, Zini, Andrea, Silvestrelli, Giorgio, Del Zotto, Elisabetta, Caso, Valeria, Dell’Acqua, Maria Luisa, Simone, Anna Maria, Lanari, Alessia, Costa, Paolo, Poli, Loris, De Giuli, Valeria, Gamba, Massimo, Ciccone, Alfonso, Ritelli, Marco, Di Castelnuovo, Augusto, Iacoviello, Licia, Colombi, Marina, Agnelli, Giancarlo, Grassi, Mario, de Gaetano, Giovanni, Padovani, Alessandro, and Pezzini, Alessandro

Published
2016
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21. The role of automated computed topography perfusion in prediction of hemorrhagic transformation after acute ischemic stroke.

Author

Elsaid, Nada, Bigliardi, Guido, Dell'Acqua, Maria Luisa, Vandelli, Laura, Ciolli, Ludovico, Picchetto, Livio, Borzì, Giuseppe, Ricceri, Riccardo, Pentore, Roberta, Vallone, Stefano, Meletti, Stefano, and Saied, Ahmed

Abstract

Introduction: The role of computed tomography perfusion (CTP) in prediction of hemorrhagic transformation (HT) has been evolving. We aimed to study the role of automated perfusion post-processing software in prediction of HT using the commercially available RAPID software. Methods: Two hundred eighty-two patients with anterior circulation ischemic stroke, who underwent CTP with RAPID automated post-processing, were retrospectively enrolled and divided into HT (n = 91) and non-HT groups (n = 191). The automated RAPID-generated perfusion maps were reviewed. Mismatch volume and ratio, time to maximum (Tmax) > 4‐10s volumes, hypoperfusion index, cerebral blood flow (CBF) < 20–38% volumes, cerebral blood volume (CBV) < 34%–42% volumes, and CBV index were recorded and analyzed. Results: The volumes of brain tissues suffering from reduction of cerebral blood flow (CBF < 20%–38%), reduction in cerebral blood volumes (CBV < 34–42%), and delayed contrast arrival times (Tmax > 4–10s) were significantly higher in the HT group. The mismatch volumes were also higher in the HT group (p =.001). Among these parameters, the Tmax > 6s volume was the most reliable and sensitive predictor of HT (p =.001, AUC = 0.667). However, the combination of the perfusion parameters can slightly improve the diagnostic efficiency (AUC = 0.703). There was no statistically significant difference between the non-HT group and either the parenchymal or the symptomatic subtypes. Conclusion: The RAPID automated CTP parameters can provide a reliable predictor of HT overall but not the parenchymal or the symptomatic subtypes. The infarct area involving the penumbra and core represented by the Tmax > 6s threshold is the most sensitive predictor; however, the combination of the perfusion parameters can slightly improve the diagnostic efficiency. [ABSTRACT FROM AUTHOR]

Published
2023
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22. Fibrinogen depletion coagulopathy predicts major bleeding after thrombolysis for ischemic stroke: A multicentre prospective study

Author

Romoli, Michele, Vandelli, Laura, Bigliardi, Guido, Naccarato, Marcello, Balestrino, Maurizio, Moller, Jessica, Musolino, Rosa Fortunata, Gentile, Mauro, Forlivesi, Stefano, Dell'Acqua, Maria Luisa, Rosafio, Francesca, Maffei, Stefania, Migliaccio, Ludovica, Trenti, Tommaso, Marietta, Marco, Mancini, Rita, Manganotti, Paolo, Melis, Maurizio, and Zini, Andrea

Published
2021
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23. Intravenous Thrombolysis in Patients With Ischemic Stroke Aged ≥90 Years: A Cohort Study From the TRISP Collaboration.

Author

Altersberger, Valerian L., Rusche, Norman, Martinez-Majander, Nicolas, Hametner, Christian, Scheitz, Jan F., Henon, Hilde, Dell'Acqua, Maria Luisa, Strambo, Davide, Stolp, Jeffrey, Heldner, Mirjam R., Grisendi, Ilaria, Jovanovic, Dejana R., Bejot, Yannick, Pezzini, Alessandro, Leker, Ronen R., Kägi, Georg, Wegener, Susanne, Cereda, Carlo W., Lindgren, Erik, and Ntaios, George

Published
2022
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25. Vascular Remodeling in Moyamoya Angiopathy: From Peripheral Blood Mononuclear Cells to Endothelial Cells

Author

Tinelli, Francesca, primary, Nava, Sara, additional, Arioli, Francesco, additional, Bedini, Gloria, additional, Scelzo, Emma, additional, Lisini, Daniela, additional, Faragò, Giuseppe, additional, Gioppo, Andrea, additional, Ciceri, Elisa F., additional, Acerbi, Francesco, additional, Ferroli, Paolo, additional, Vetrano, Ignazio G., additional, Esposito, Silvia, additional, Saletti, Veronica, additional, Pantaleoni, Chiara, additional, Zibordi, Federica, additional, Nardocci, Nardo, additional, Zedde, Maria Luisa, additional, Pezzini, Alessandro, additional, Di Lazzaro, Vincenzo, additional, Capone, Fioravante, additional, Dell’Acqua, Maria Luisa, additional, Vajkoczy, Peter, additional, Tournier-Lasserve, Elisabeth, additional, Parati, Eugenio A., additional, Bersano, Anna, additional, and Gatti, Laura, additional

Published
2020
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26. Screening for Fabry disease in patients with ischaemic stroke at young age: the Italian Project on Stroke in Young Adults

Author

Poli, L., Zedde, Marialuisa, Zini, Andrea, Del Sette, Massimo, Lodigiani, Corrado, Spalloni, Alessandra, Di Lisi, Filomena, Toriello, Antonella, Piras, Valeria, Stilo, Cesare, Tomelleri, Giampaolo, Tancredi, Lucia, Paciaroni, Maurizio, Silvestrelli, Giorgio, Adami, Alessandro, Costa, P., Morotti, A., De Giuli, V., Caria, F., Gamba, Massimo, Malferrari, Giovanni, Simone, Anna Maria, Musolino, Rossella, Giorli, Elisa, Banfi, Elena, Marcheselli, Simona, Rasura, Maurizia, Pugliese, Nicola, Melis, Maurizio, Bovi, Paolo, Padovani, A., Burlina, A., Pezzini, A, Del Zotto, Elisabetta, Giossi, Alessia, Sessa, Maria, Gilberti, Nicola, Magoni, Mauro, Ferrazzi, Paola, Librã¨, Luca, Rota, Lidia Luciana, Patella, Rosalba, Calabrã², Rocco Salvatore, Bramanti, Placido, La Spina, Paolo, Finocchi, Cinzia, Balestrino, Maurizio, Bruno, Chiara, Massucco, Davide, Gandolfo, Carlo, Traverso, Elisabetta, Delodovici, Maria Luisa, Verrengia, Elena Pinuccia, Carimati, Federico, Bono, GIORGIO GIOVANNI, Dell'Acqua, Maria Luisa, Bigliardi, Guido, Vandelli, Laura, Nichelli, Paolo Frigio, Carletti, Monica, Cerrato, Paolo, Iacoviello, Licia, Di Castelnuovo, Augusto, de Gaetano, Giovanni, Grassi, Mario, Locatelli, Giampiero, Caso, Valeria, D'Amore, Cataldo, Agnelli, Giancarlo, Checcarelli, Nicoletta, Guidotti, Mario, Arnaboldi, Marco, Giacalone, Giacomo, Zanoli, Elisa, Cavallini, Anna, Persico, Alessandra, Micieli, Giuseppe, Chiti, Alberto, Orlandi, Giovanni, Marchi, Piernicola, Lanari, Alessia, Ciccone, Alfonso, Cucurachi, Laura, Bonifati, Marco Domenico, and Marcello, Norina

Subjects
Pediatrics, medicine.medical_specialty, Neurology, 030204 cardiovascular system & hematology, Fabry disease, ischaemic, stroke, young, Neurology (clinical), Brain ischemia, 03 medical and health sciences, 0302 clinical medicine, Ischaemic stroke, Medicine, In patient, cardiovascular diseases, Young adult, Stroke, business.industry, medicine.disease, Young age, business, 030217 neurology & neurosurgery
Published
2017
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28. Fibrinogen concentrate replacement in ischemic stroke patients after recombinant tissue plasminogen activator treatment.

Author

Vandelli, Laura, Marietta, Marco, Trenti, Tommaso, Varani, Manuela, Bigliardi, Guido, Rosafio, Francesca, Dell'Acqua, Maria Luisa, Picchetto, Livio, Nichelli, Paolo, and Zin, Andrea

Subjects
THROMBOLYTIC therapy, PLASMINOGEN activators, STROKE patients, FIBRINOGEN
Abstract

Background. Post-thrombotic intracerebral hemorrhage (ICH) is experienced by 6-8% of stroke patients and is associated with multiple factors, including acquired coagulopathy induced by the thrombolytic drug. Objectives. The objective of this study was to assess the outcome of the intravenous (IV) administration of fibrinogen concentrate in a series of acute stroke patients who developed iatrogenic fibrinogen critical depletion after IV thrombolysis. Material and methods. Of the 39 ischemic stroke patients treated with IV thrombolysis with a severe hypofibrinogenemia requiring infusion with IV fibrinogen concentrate, 30 patients were treated with 2 g of IV recombinant tissue plasminogen activator (rt-PA), followed by further doses until the fibrinogen level reached 200 mg/dL in hemorrhagic patients or 100 mg/dL in non-hemorrhagic patients, and 9 were treated with IV rt-PA followed by endovascular thrombectomy. Results. Pre- and post-thrombolysis National Institutes of Health Stroke Scale (NIHSS) scores were statistically different for the Cochran-Mantel-Haenszel test overall (p = 0.0002), at 24-hour evaluation (p = 0.0455) and at 7-day assessment (p = 0.0006). Within the first 7 days post-thrombolysis, the brain computed tomography (CT) scans showed that 20/39 (51.28%) patients had ICH. Of the whole sample, 25.6% of the ICH patients had symptomatic intracerebral hemorrhage (SICH), according to National Institute of Neurological Disorders and Stroke (NINDS) classification. After rt-PA treatment, the median pre-thrombolysis fibrinogenemia of 332 mg/dL significantly dropped to 133 mg/dL (p < 0.0001). After the fibrinogen concentrate infusion, the median level of fibrinogenemia rose to 160 mg/dL, which was significantly higher than the median postthrombolysis levels (p < 0.0001). Recanalization was observed in 25/28 patients (89.29%): complete in 18 and partial in 7 patients. After fibrinogen IV infusion, no thrombotic complications were seen in 37 out of 39 patients (94.77%); 2/39 (0.05%) patients experienced a pulmonary embolism, 1 of them a segmental one. Conclusions. This study showed the clinical safety of administering IV fibrinogen concentrate in order to increase plasma fibrinogen levels in a series of acute stroke patients with iatrogenic fibrinogen depletion after IV thrombolysis. [ABSTRACT FROM AUTHOR]

Published
2019
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29. Endovascular therapy in patients with acute intracranial non-terminal internal carotid artery occlusion (ICA-I)

Author

Riegler, Christoph, von Rennenberg, Regina, Bollweg, Kerstin, Siebert, Eberhard, de Marchis, Gian Marco, Kägi, Georg, Mordasini, Pasquale, Heldner, Mirjam R, Magoni, Mauro, Pezzini, Alessandro, Salerno, Alexander, Michel, Patrik, Globas, Christoph, Wegener, Susanne, Martinez-Majander, Nicolas, Curtze, Sami, Dell’Acqua, Maria Luisa, Bigliardi, Guido, Wali, Nabila, Nederkoorn, Paul J, Jovanovic, Dejana R, Padjen, Visnja, Metanis, Issa, Leker, Ronen R., Bianco, Giovanni, Cereda, Carlo W, Pascarella, Rosario, Zedde, Marialuisa, Viola, Maria Maddalena, Zini, Andrea, Ramos, João Nuno, Marto, João Pedro, Audebert, Heinrich J, Trüssel, Simon, Gensicke, Henrik, Engelter, Stefan T, and Nolte, Christian H

Abstract

Background: Acute intracranial occlusion of the internal carotid artery (ICA) can be distinguished into (a) occlusion of the terminal ICA, involving the proximal segments of the middle or anterior cerebral artery (ICA-L/-T) and (b) non-terminal intracranial occlusions of the ICA with patent circle of Willis (ICA-I). While patients with ICA-L/-T occlusion were included in all randomized controlled trials on endovascular therapy (EVT) in anterior large vessel occlusion, data on EVT in ICA-I occlusion is scarce. We thus aimed to evaluate effectiveness and safety of EVT in ICA-I occlusions in comparison to ICA-L/-T occlusions.Methods: A large international multicentre cohort was searched for patients with intracranial ICA occlusion treated with EVT between 2014 and 2023. Patients were stratified by ICA occlusion pattern, differentiating ICA-I and ICA-L/-T occlusions. Baseline factors, technical (modified thrombolysis in cerebral infarction (mTICI) scale) and functional outcomes (modified Rankin scale [mRS] at 3 months) as well as rates of (symptomatic) intracranial hemorrhage ([s]ICH) were analyzed.Results: Of 13,453 patients, 1825 (13.6%) had isolated ICA occlusion. ICA-occlusion pattern was ICA-I in 559 (4.2%) and ICA-L/-T in 1266 (9.4%) patients. Age (years: 74 vs 73), sex (female: 45.8% vs 49.0%) and pre-stroke functional independency (pre-mRS ⩽ 2: 89.9% vs 92.2%) did not differ between the groups. Stroke severity was lower in ICA-I patients (NIHSS at admission: 14 [7–19] vs 17 [13–21] points). EVT was similarly successful with respect to technical (mTICI2b/3: 76.1% (ICA-I) vs 76.6% (ICA-L/-T); aOR 1.01 [0.76–1.35]) and functional outcome (mRS ordinal shift cOR 1.01 [0.83–1.23] in adjusted analyses. Rates of ICH (18.9% vs 34.5%; aOR 0.47 [0.36–0.62] and sICH (4.7% vs 7.3%; aOR 0.58 [0.35–0.97] were lower in ICA-I patients.Conclusion: EVT might be performed safely and similarly successful in patients with ICA-I occlusions as in patients with ICA-L/-T occlusions.

Published
2024
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30. Endovascular treatment in patients with acute ischemic stroke presenting beyond 6 h after symptom onset: An international multicenter cohort study of the EVA-TRISP collaboration

Author

Wali, Nabila, Stolze, Lotte J, Rinkel, Leon A., Heldner, Mirjam R, Müller, Madlaine, Arnold, Marcel, Mordasini, Pasquale, Gralla, Jan, Baumgartner, Philipp, Inauen, Corinne, Westphal, Laura P, Wegener, Susanne, Michel, Patrik, Trüssel, Simon, Mannismäki, Laura, Martinez-Majander, Nicolas, Curtze, Sami, Kägi, Georg, Picchetto, Livio, Dell’Acqua, Maria Luisa, Bigliardi, Guido, Riegler, Christoph, Nolte, Christian H, Serôdio, Miguel, Miranda, Miguel, Marto, João Pedro, Zini, Andrea, Forlivesi, Stefano, Gentile, Luana, Cereda, Carlo W, Pezzini, Alessandro, Leker, Ronen R, Honig, Asaf, Berisavac, Ivana, Padjen, Visnja, Zedde, Marialuisa, Kuhrij, Laurien S, Van den Berg-Vos, Renske M, Engelter, Stefan T, Gensicke, Henrik, and Nederkoorn, Paul J

Abstract

Introduction: After positive findings in clinical trials the time window for endovascular thrombectomy (EVT) for patients with an acute ischemic stroke has been expanded up to 24 h from symptom onset or last seen well (LSW). We aimed to compare EVT patients’ characteristics and outcomes in the early versus extended time window and to compare outcomes with the DAWN and DEFUSE 3 trial results.Patients and methods: Consecutive EVT patients from 16 mostly European comprehensive stroke centers from the EVA-TRISP cohort were included. We compared rates of 90-day good functional outcomes (Modified Rankin Scale 0–2), symptomatic intracranial hemorrhage (sICH), and 90-day mortality between patients treated in the early (<6 h after onset or LSW) versus extended (6–24 h after onset or LSW) time windows.Results: We included 9313 patients, of which 6876 were treated in the early and 2437 in the extended time window. National Institutes of Health Stroke Scale (NIHSS) score at presentation was lower in patients treated in the extended time window (median 13 [IQR 7–18] vs 15 [IQR 9–19], p< 0.001). The percentage of patients with good functional outcome was slightly lower in the extended time window (37.4% vs 42.2%, p< 0.001). However, rates of successful recanalization, sICH, and mortality were similar. Good functional outcome rates after EVT were slightly lower for patients in the extended window in the EVA-TRISP cohort as compared to DAWN and DEFUSE 3.Discussion and conclusion: According to this large multicenter cohort study reflecting daily clinical practice, EVT use in the extended time window appears safe and effective.

Published
2024
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31. Intravenous thrombolysis or endovascular therapy for acute ischemic stroke associated with cervical internal carotid artery occlusion: the ICARO-3 study

Author

Paciaroni, Maurizio, primary, Inzitari, Domenico, additional, Agnelli, Giancarlo, additional, Caso, Valeria, additional, Balucani, Clotilde, additional, Grotta, James C., additional, Sarraj, Amrou, additional, Sung-Il, Sohn, additional, Chamorro, Angel, additional, Urra, Xabier, additional, Leys, Didier, additional, Henon, Hilde, additional, Cordonnier, Charlotte, additional, Dequatre, Nelly, additional, Aguettaz, Pierre, additional, Alberti, Andrea, additional, Venti, Michele, additional, Acciarresi, Monica, additional, D’Amore, Cataldo, additional, Zini, Andrea, additional, Vallone, Stefano, additional, Dell’Acqua, Maria Luisa, additional, Menetti, Federico, additional, Nencini, Patrizia, additional, Mangiafico, Salvatore, additional, Barlinn, Kristian, additional, Kepplinger, Jessica, additional, Bodechtel, Ulf, additional, Gerber, Johannes, additional, Bovi, Paolo, additional, Cappellari, Manuel, additional, Linfante, Italo, additional, Dabus, Guilherme, additional, Marcheselli, Simona, additional, Pezzini, Alessandro, additional, Padovani, Alessandro, additional, Alexandrov, Andrei V., additional, Shahripour, Reza Bavarsad, additional, Sessa, Maria, additional, Giacalone, Giacomo, additional, Silvestrelli, Giorgio, additional, Lanari, Alessia, additional, Ciccone, Alfonso, additional, De Vito, Alessandro, additional, Azzini, Cristiano, additional, Saletti, Andrea, additional, Fainardi, Enrico, additional, Orlandi, Giovanni, additional, Chiti, Alberto, additional, Gialdini, Gino, additional, Silvestrini, Mauro, additional, Ferrarese, Carlo, additional, Beretta, Simone, additional, Tassi, Rossana, additional, Martini, Giuseppe, additional, Tsivgoulis, Georgios, additional, Vasdekis, Spyros N., additional, Consoli, Domenico, additional, Baldi, Antonio, additional, D’Anna, Sebastiano, additional, Luda, Emilio, additional, Varbella, Ferdinando, additional, Galletti, Giampiero, additional, Invernizzi, Paolo, additional, Donati, Edoardo, additional, De Lodovici, Maria Luisa, additional, Bono, Giorgio, additional, Corea, Francesco, additional, Sette, Massimo Del, additional, Monaco, Serena, additional, Riva, Maurizio, additional, Tassinari, Tiziana, additional, Scoditti, Umberto, additional, and Toni, Danilo, additional

Published
2014
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32. Antithrombotic medications and the etiology of intracerebral hemorrhage

Author

Pezzini, Alessandro, primary, Grassi, Mario, additional, Paciaroni, Maurizio, additional, Zini, Andrea, additional, Silvestrelli, Giorgio, additional, Del Zotto, Elisabetta, additional, Caso, Valeria, additional, Dell'Acqua, Maria Luisa, additional, Giossi, Alessia, additional, Volonghi, Irene, additional, Simone, Anna Maria, additional, Lanari, Alessia, additional, Costa, Paolo, additional, Poli, Loris, additional, Morotti, Andrea, additional, De Giuli, Valeria, additional, Pepe, Daniele, additional, Gamba, Massimo, additional, Ciccone, Alfonso, additional, Ritelli, Marco, additional, Colombi, Marina, additional, Agnelli, Giancarlo, additional, and Padovani, Alessandro, additional

Published
2014
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37. Expression of ectonucleotidase CD39 by Foxp3+Treg cells: hydrolysis of extracellular ATP and immune suppression

Author

Borsellino, Giovanna, Kleinewietfeld, Markus, Di Mitri, Diletta, Sternjak, Alexander, Diamantini, Adamo, Giometto, Raffaella, Höpner, Sabine, Centonze, Diego, Bernardi, Giorgio, Dell'Acqua, Maria Luisa, Rossini, Paolo Maria, Battistini, Luca, Rötzschke, Olaf, and Falk, Kirsten

Abstract

In the immune system, extracellular ATP functions as a “natural adjuvant” that exhibits multiple proinflammatory effects. It is released by damaged cells as an indicator of trauma and cell death but can be inactivated by CD39 (nucleoside triphosphate diphosphohydrolase-1 [NTPDase 1]), an ectoenzyme that degrades ATP to AMP. Here, we show that CD39 is expressed primarily by immune-suppressive Foxp3+regulatory T (Treg) cells. In mice, the enzyme is present on virtually all CD4+CD25+cells. CD39 expression is driven by the Treg-specific transcription factor Foxp3 and its catalytic activity is strongly enhanced by T-cell receptor (TCR) ligation. Activated Treg cells are therefore able to abrogate ATP-related effects such as P2 receptor-mediated cell toxicity and ATP-driven maturation of dendritic cells. Also, human Treg cells express CD39. In contrast to mice, CD39 expression in man is restricted to a subset of Foxp3+regulatory effector/memory-like T (TREM) cells. Notably, patients with the remitting/relapsing form of multiple sclerosis (MS) have strikingly reduced numbers of CD39+Treg cells in the blood. Thus, in humans CD39 is a marker of a Treg subset likely involved in the control of the inflammatory autoimmune disease.

Published
2007
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38. Factors affecting the outcome of delayed intravenous thrombolysis (>4.5 hours)

Author

Elsaid, Nada, Bigliardi, Guido, Dell’Acqua, Maria Luisa, Vandelli, Laura, Ciolli, Ludovico, Picchetto, Livio, Borzì, Giuseppe, Ricceri, Riccardo, Pentore, Roberta, Vallone, Stefano, Meletti, Stefano, and Saied, Ahmed

Abstract

Introduction: Evidence of the intravenous tissue plasminogen activator (tPA) efficacy beyond the 4.5 hours window is emerging. We aim to study the factors affecting the outcome of delayed thrombolysis in patients of clear onset acute ischemic stroke (AIS).

Published
2021
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