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2. Two years later: Is the SARS-CoV-2 pandemic still having an impact on emergency surgery? An international cross-sectional survey among WSES members
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Reichert, M, Sartelli, M, Weigand, M, Hecker, M, Oppelt, P, Noll, J, Askevold, I, Liese, J, Padberg, W, Coccolini, F, Catena, F, Hecker, A, Peckham-Cooper, A, Camacho-Ortiz, A, Mastoraki, A, Landaluce-Olavarria, A, Pal, A, Kuriyama, A, Chichom-Mefire, A, Porcu, A, Martinez-Perez, A, Karamarkovic, A, Osipov, A, Coppola, A, Cucchetti, A, Spolini, A, Giordano, A, Reinisch-Liese, A, Kavalakat, A, Vasilescu, A, Alamin, A, Gupta, A, Dascalu, A, Musina, A, Bakopoulos, A, Zakaria, A, Vereczkei, A, Balla, A, Bottari, A, Baumann, A, Fette, A, Litvin, A, Reichert, A, Guariniello, A, Paspala, A, Schneck, A, Brillantino, A, Pesce, A, Isik, A, Leppaniemi, A, Papadopoulos, A, Kechagias, A, Mohamed, A, Mitul, A, Marinis, A, Syllaios, A, Mantoglu, B, De Simone, B, Weiss, B, Posentrup, B, Picardi, B, Zampogna, B, Sakakushev, B, Atanasov, B, Nardo, B, Calik, B, Cremonini, C, Ordonez, C, Seretis, C, Cascone, C, Chouliaras, C, Bendinelli, C, Lopes, C, Guerci, C, Weber, C, Nastos, C, Mesina, C, Caputo, D, Massalou, D, Cavaliere, D, Mcnamara, D, Demetriades, D, Pantalone, D, Coletta, D, Sasia, D, Visconti, D, Weber, D, Corallino, D, Chatzipetris, D, Manatakis, D, Ntourakis, D, Papaconstantinou, D, Schizas, D, Chrysikos, D, Adamovich, D, Elkafrawy, D, Seban, D, Garcia, E, Baldini, E, Picetti, E, Tan, E, Baili, E, Lostoridis, E, Toma, E, Colak, E, Cerutti, E, Steyn, E, Hsabo, E, Kapetanakis, E, Kaouras, E, Schneck, E, Akin, E, Gonullu, E, Celik, E, Cicuttin, E, Pinotti, E, Johnsson, E, Moore, E, Agastra, E, Dimitrov, E, Griffiths, E, D'Acapito, F, Saraceno, F, Alconchel, F, Zeppernick, F, Rodriguez, F, Abu-Zidan, F, Pecchini, F, Favi, F, Ferrara, F, Fleres, F, Pata, F, Roscio, F, Mulita, F, Dor, F, Linder, F, Dimofte, G, Rodrigues, G, Nita, G, Sganga, G, Martines, G, Mazzarella, G, Perrone, G, Velmahos, G, Lianos, G, Tomadze, G, Baiocchi, G, D'Ambrosio, G, Pellino, G, Pattacini, G, Giraudo, G, Lisi, G, Tebala, G, Pirozzolo, G, Montori, G, Argenio, G, Brisinda, G, Curro, G, Giuliani, G, Palomba, G, Roscitano, G, Avsar, G, Augustin, G, Clarizia, G, Vega, G, Fraga, G, Sethi, H, Eltyeb, H, Lohse, H, Bayhan, H, Hamid, H, Kryvoruchko, I, Iannone, I, Wani, I, Lazaridis, I, Katsaros, I, Nikolopoulos, I, Negoi, I, Reccia, I, Di Carlo, I, Olaoye, I, Czepiel, J, Kim, J, Meyer, J, Terrazas, J, Tochie, J, Galante, J, Davies, J, Sugand, K, Gonfa, K, Rasa, K, Kok, K, Apostolou, K, Lasithiotakis, K, Tsekouras, K, Angamuthu, K, Akhmeteli, L, Sydorchuk, L, Fortuna, L, Siragusa, L, Pagani, L, Solaini, L, Miller, L, Bains, L, Ansaloni, L, Ferrario, L, Bonavina, L, Conti, L, Buonomo, L, Tallon-Aguilar, L, Tomczyk, L, Widmer, L, Waledziak, M, Gachabayov, M, Bulanauca, M, Malbrain, M, Maegele, M, Catarci, M, Ceresoli, M, Ranucci, M, Antonopoulou, M, Papadoliopoulou, M, Valenti, M, Sotiropoulou, M, D'Oria, M, Martin, M, Hirschburger, M, Veroux, M, Fantoni, M, Nardi, M, Tolonen, M, Montuori, M, Podda, M, Scheiterle, M, Frountzas, M, Sarikaya, M, Yildirim, M, Bender, M, Vailas, M, Teuben, M, Campanelli, M, Ammendola, M, Malerba, M, Pisano, M, Pertea, M, Slavchev, M, Ukkonen, M, Bala, M, Chirica, M, Barone, M, Shaat, M, Mohammed, M, Abuelgasim, M, Gureh, M, Ouadii, M, Balkan, M, Mohamed, M, Hakseven, M, Velenciuc, N, Cillara, N, De'Angelis, N, Tamini, N, Zavras, N, Machairas, N, Michalopoulos, N, Koliakos, N, Pararas, N, Donlon, N, Medappil, N, Ben-Ishay, O, Stefano, O, Islam, O, Tammo, O, Ioannidis, O, Aparicio, O, Baraket, O, Kumar, P, Cianci, P, Ortenwall, P, Uchikov, P, de Reuver, P, Stahel, P, Barie, P, Piccoli, M, Major, P, Navsaria, P, Sasmal, P, Coimbra, R, Rahim, R, Capoglu, R, Koshy, R, Gonsaga, R, Pertile, R, Mohamed, R, Deryol, R, Sawyer, R, Angelico, R, Ragozzino, R, Bini, R, Cammarata, R, Scaramuzzo, R, Gioco, R, Sydorchuk, R, Ahmed, S, Di Saverio, S, Emile, S, Delibegovic, S, Marwah, S, Symeonidis, S, Thomas, S, Demir, S, Awad, S, Atici, S, Chooklin, S, Meric, S, Sarikaya, S, Chowdhury, S, Mirghani, S, Wren, S, Gargarella, S, Del Monte, S, Esposito, S, Xenaki, S, Mohamed, S, Beka, S, Lunca, S, Delis, S, Dritsas, S, Morarasu, S, Magnone, S, Rossi, S, Bitsianis, S, Kykalos, S, Baral, S, Jain, S, Ali, S, Pintar, T, Triantafyllou, T, Delko, T, Perra, T, Sidiropoulos, T, Scalea, T, Vilz, T, Hardcastle, T, Wannatoop, T, Herzog, T, Mishra, T, Boggi, U, Calu, V, Tomajer, V, Agnoletti, V, Lohsiriwat, V, Kong, V, Munoz-Cruzado, V, Shelat, V, Khokha, V, Ghannam, W, Biffl, W, Zuidema, W, Kara, Y, Kobe, Y, Demetrashvili, Z, Memish, Z, Madrazo, Z, Balogh, Z, Bayhan, Z, Reichert M., Sartelli M., Weigand M. A., Hecker M., Oppelt P. U., Noll J., Askevold I. H., Liese J., Padberg W., Coccolini F., Catena F., Hecker A., Peckham-Cooper A., Camacho-Ortiz A., Mastoraki A. T., Landaluce-Olavarria A., Pal A. K., Kuriyama A., Chichom-Mefire A., Porcu A., Martinez-Perez A., Karamarkovic A. R., Osipov A. V., Coppola A., Cucchetti A., Spolini A., Giordano A., Reinisch-Liese A., Kavalakat A. J., Vasilescu A., Alamin A., Gupta A., Dascalu A. M., Musina A. -M., Bakopoulos A., Zakaria A. D., Vereczkei A., Balla A., Bottari A., Baumann A., Fette A., Litvin A., Reichert A. K., Guariniello A., Paspala A., Schneck A. -S., Brillantino A., Pesce A., Isik A., Leppaniemi A. K., Papadopoulos A., Kechagias A., Mohamed A. Y. A., Mitul A. R., Marinis A., Syllaios A., Mantoglu B., De Simone B., Weiss B. S., Posentrup B., Picardi B., Zampogna B., Sakakushev B. E., Atanasov B. C., Nardo B., Calik B., Cremonini C., Ordonez C. A., Seretis C., Cascone C., Chouliaras C., Bendinelli C., Lopes C., Guerci C., Weber C., Nastos C., Mesina C., Caputo D., Massalou D., Cavaliere D., McNamara D. A., Demetriades D., Pantalone D., Coletta D., Sasia D., Visconti D., Weber D. G., Corallino D., Chatzipetris D., Manatakis D. K., Ntourakis D., Papaconstantinou D., Schizas D., Chrysikos D., Adamovich D. M., Elkafrawy D., Seban D., Garcia E. F. H., Baldini E., Picetti E., Tan E. C. T. H., Baili E., Lostoridis E., Toma E. A., Colak E., Cerutti E., Steyn E., Hsabo E. A., Kapetanakis E. I., Kaouras E., Schneck E., Akin E., Gonullu E., celik E., Cicuttin E., Pinotti E., Johnsson E., Moore E. E., Agastra E., Dimitrov E. N., Griffiths E. A., D'Acapito F., Saraceno F., Alconchel F., Zeppernick F. A., Rodriguez F. M., Abu-Zidan F., Pecchini F., Favi F., Ferrara F., Fleres F., Pata F., Roscio F. P. M., Mulita F., Dor F. J. M. F., Linder F., Dimofte G., Rodrigues G., Nita G., Sganga G., Martines G., Mazzarella G., Perrone G., Velmahos G., Lianos G. D., Tomadze G., Baiocchi G. L., D'Ambrosio G., Pellino G., Pattacini G. C., Giraudo G., Lisi G., Tebala G. D., Pirozzolo G., Montori G., Argenio G., Brisinda G., Curro G., Giuliani G., Palomba G., Roscitano G., Avsar G., Augustin G., Clarizia G., Vega G. M. M., Fraga G. P., Sethi H., Eltyeb H. A., Lohse H. A. S., Lohse H. R. S., Bayhan H., Hamid H. K. S., Kryvoruchko I. A., Iannone I., Wani I., Lazaridis I. I., Katsaros I., Nikolopoulos I., Negoi I., Reccia I., Di Carlo I., Olaoye I. O., Czepiel J., Kim J. I., Meyer J., Terrazas J. M. S., Tochie J. N., Galante J. M., Davies J., Sugand K., Gonfa K. B., Rasa K., Kok K. Y. Y., Apostolou K. G., Lasithiotakis K., Tsekouras K., Angamuthu K., Akhmeteli L., Sydorchuk L., Fortuna L., Siragusa L., Pagani L., Solaini L., Miller L. A., Bains L., Ansaloni L., Ferrario L., Bonavina L., Conti L., Buonomo L. A., Tallon-Aguilar L., Tomczyk L., Widmer L. W., Waledziak M., Gachabayov M., Bulanauca M. M., Malbrain M. L. N. G., Maegele M., Catarci M., Ceresoli M., Ranucci M. C., Antonopoulou M. I., Papadoliopoulou M., Valenti M. R., Sotiropoulou M., D'Oria M., Martin M. S., Hirschburger M., Veroux M., Fantoni M., Nardi M., Tolonen M., Montuori M., Podda M., Scheiterle M., Frountzas M., Sarikaya M., Yildirim M., Bender M., Vailas M., Teuben M., Campanelli M., Ammendola M., Malerba M., Pisano M., Pertea M., Slavchev M., Ukkonen M., Bala M., Chirica M., Barone M., Shaat M. M., Mohammed M. J. S., Abuelgasim M. A. A., Gureh M., Ouadii M., Balkan M., Mohamed M., Hakseven M., Velenciuc N., Cillara N., de'Angelis N., Tamini N., Zavras N. J., Machairas N., Michalopoulos N., Koliakos N. N., Pararas N., Donlon N. E., Medappil N., Ben-Ishay O., Stefano O., Islam O., Tammo O., Ioannidis O., Aparicio O., Baraket O., Kumar P., Cianci P., Ortenwall P., Uchikov P. A., de Reuver P., Stahel P. F., Barie P. S., Piccoli M., Major P., Navsaria P. H., Sasmal P. K., Coimbra R., Rahim R., Capoglu R., Koshy R. M., Gonsaga R. A. T., Pertile R., Mohamed R. R. M., Deryol R., Sawyer R. G., Angelico R., Ragozzino R., Bini R., Cammarata R., Scaramuzzo R., Gioco R., Sydorchuk R., Ahmed S., Di Saverio S., Emile S. H., Delibegovic S., Marwah S., Symeonidis S., Thomas S. G., Demir S., Awad S. S., Atici S. D., Chooklin S., Meric S., Sarikaya S., Chowdhury S., Mirghani S. F., Wren S. M., Gargarella S., Del Monte S. R., Esposito S., Xenaki S., Mohamed S. F. G., Beka S. G., Lunca S., Delis S. G., Dritsas S., Morarasu S., Magnone S., Rossi S., Bitsianis S., Kykalos S., Baral S., Jain S. A., Ali S. M., Pintar T., Triantafyllou T., Delko T., Perra T., Sidiropoulos T. A., Scalea T. M., Vilz T. O., Hardcastle T. C., Wannatoop T., Herzog T., Mishra T. S., Boggi U., Calu V., Tomajer V., Agnoletti V., Lohsiriwat V., Kong V., Munoz-Cruzado V. D., Shelat V. G., Khokha V., Ghannam W. M., Biffl W. L., Zuidema W., Kara Y., Kobe Y., Demetrashvili Z., Memish Z. A., Madrazo Z., Balogh Z. J., Bayhan Z., Reichert, M, Sartelli, M, Weigand, M, Hecker, M, Oppelt, P, Noll, J, Askevold, I, Liese, J, Padberg, W, Coccolini, F, Catena, F, Hecker, A, Peckham-Cooper, A, Camacho-Ortiz, A, Mastoraki, A, Landaluce-Olavarria, A, Pal, A, Kuriyama, A, Chichom-Mefire, A, Porcu, A, Martinez-Perez, A, Karamarkovic, A, Osipov, A, Coppola, A, Cucchetti, A, Spolini, A, Giordano, A, Reinisch-Liese, A, Kavalakat, A, Vasilescu, A, Alamin, A, Gupta, A, Dascalu, A, Musina, A, Bakopoulos, A, Zakaria, A, Vereczkei, A, Balla, A, Bottari, A, Baumann, A, Fette, A, Litvin, A, Reichert, A, Guariniello, A, Paspala, A, Schneck, A, Brillantino, A, Pesce, A, Isik, A, Leppaniemi, A, Papadopoulos, A, Kechagias, A, Mohamed, A, Mitul, A, Marinis, A, Syllaios, A, Mantoglu, B, De Simone, B, Weiss, B, Posentrup, B, Picardi, B, Zampogna, B, Sakakushev, B, Atanasov, B, Nardo, B, Calik, B, Cremonini, C, Ordonez, C, Seretis, C, Cascone, C, Chouliaras, C, Bendinelli, C, Lopes, C, Guerci, C, Weber, C, Nastos, C, Mesina, C, Caputo, D, Massalou, D, Cavaliere, D, Mcnamara, D, Demetriades, D, Pantalone, D, Coletta, D, Sasia, D, Visconti, D, Weber, D, Corallino, D, Chatzipetris, D, Manatakis, D, Ntourakis, D, Papaconstantinou, D, Schizas, D, Chrysikos, D, Adamovich, D, Elkafrawy, D, Seban, D, Garcia, E, Baldini, E, Picetti, E, Tan, E, Baili, E, Lostoridis, E, Toma, E, Colak, E, Cerutti, E, Steyn, E, Hsabo, E, Kapetanakis, E, Kaouras, E, Schneck, E, Akin, E, Gonullu, E, Celik, E, Cicuttin, E, Pinotti, E, Johnsson, E, Moore, E, Agastra, E, Dimitrov, E, Griffiths, E, D'Acapito, F, Saraceno, F, Alconchel, F, Zeppernick, F, Rodriguez, F, Abu-Zidan, F, Pecchini, F, Favi, F, Ferrara, F, Fleres, F, Pata, F, Roscio, F, Mulita, F, Dor, F, Linder, F, Dimofte, G, Rodrigues, G, Nita, G, Sganga, G, Martines, G, Mazzarella, G, Perrone, G, Velmahos, G, Lianos, G, Tomadze, G, Baiocchi, G, D'Ambrosio, G, Pellino, G, Pattacini, G, Giraudo, G, Lisi, G, Tebala, G, Pirozzolo, G, Montori, G, Argenio, G, Brisinda, G, Curro, G, Giuliani, G, Palomba, G, Roscitano, G, Avsar, G, Augustin, G, Clarizia, G, Vega, G, Fraga, G, Sethi, H, Eltyeb, H, Lohse, H, Bayhan, H, Hamid, H, Kryvoruchko, I, Iannone, I, Wani, I, Lazaridis, I, Katsaros, I, Nikolopoulos, I, Negoi, I, Reccia, I, Di Carlo, I, Olaoye, I, Czepiel, J, Kim, J, Meyer, J, Terrazas, J, Tochie, J, Galante, J, Davies, J, Sugand, K, Gonfa, K, Rasa, K, Kok, K, Apostolou, K, Lasithiotakis, K, Tsekouras, K, Angamuthu, K, Akhmeteli, L, Sydorchuk, L, Fortuna, L, Siragusa, L, Pagani, L, Solaini, L, Miller, L, Bains, L, Ansaloni, L, Ferrario, L, Bonavina, L, Conti, L, Buonomo, L, Tallon-Aguilar, L, Tomczyk, L, Widmer, L, Waledziak, M, Gachabayov, M, Bulanauca, M, Malbrain, M, Maegele, M, Catarci, M, Ceresoli, M, Ranucci, M, Antonopoulou, M, Papadoliopoulou, M, Valenti, M, Sotiropoulou, M, D'Oria, M, Martin, M, Hirschburger, M, Veroux, M, Fantoni, M, Nardi, M, Tolonen, M, Montuori, M, Podda, M, Scheiterle, M, Frountzas, M, Sarikaya, M, Yildirim, M, Bender, M, Vailas, M, Teuben, M, Campanelli, M, Ammendola, M, Malerba, M, Pisano, M, Pertea, M, Slavchev, M, Ukkonen, M, Bala, M, Chirica, M, Barone, M, Shaat, M, Mohammed, M, Abuelgasim, M, Gureh, M, Ouadii, M, Balkan, M, Mohamed, M, Hakseven, M, Velenciuc, N, Cillara, N, De'Angelis, N, Tamini, N, Zavras, N, Machairas, N, Michalopoulos, N, Koliakos, N, Pararas, N, Donlon, N, Medappil, N, Ben-Ishay, O, Stefano, O, Islam, O, Tammo, O, Ioannidis, O, Aparicio, O, Baraket, O, Kumar, P, Cianci, P, Ortenwall, P, Uchikov, P, de Reuver, P, Stahel, P, Barie, P, Piccoli, M, Major, P, Navsaria, P, Sasmal, P, Coimbra, R, Rahim, R, Capoglu, R, Koshy, R, Gonsaga, R, Pertile, R, Mohamed, R, Deryol, R, Sawyer, R, Angelico, R, Ragozzino, R, Bini, R, Cammarata, R, Scaramuzzo, R, Gioco, R, Sydorchuk, R, Ahmed, S, Di Saverio, S, Emile, S, Delibegovic, S, Marwah, S, Symeonidis, S, Thomas, S, Demir, S, Awad, S, Atici, S, Chooklin, S, Meric, S, Sarikaya, S, Chowdhury, S, Mirghani, S, Wren, S, Gargarella, S, Del Monte, S, Esposito, S, Xenaki, S, Mohamed, S, Beka, S, Lunca, S, Delis, S, Dritsas, S, Morarasu, S, Magnone, S, Rossi, S, Bitsianis, S, Kykalos, S, Baral, S, Jain, S, Ali, S, Pintar, T, Triantafyllou, T, Delko, T, Perra, T, Sidiropoulos, T, Scalea, T, Vilz, T, Hardcastle, T, Wannatoop, T, Herzog, T, Mishra, T, Boggi, U, Calu, V, Tomajer, V, Agnoletti, V, Lohsiriwat, V, Kong, V, Munoz-Cruzado, V, Shelat, V, Khokha, V, Ghannam, W, Biffl, W, Zuidema, W, Kara, Y, Kobe, Y, Demetrashvili, Z, Memish, Z, Madrazo, Z, Balogh, Z, Bayhan, Z, Reichert M., Sartelli M., Weigand M. A., Hecker M., Oppelt P. U., Noll J., Askevold I. H., Liese J., Padberg W., Coccolini F., Catena F., Hecker A., Peckham-Cooper A., Camacho-Ortiz A., Mastoraki A. T., Landaluce-Olavarria A., Pal A. K., Kuriyama A., Chichom-Mefire A., Porcu A., Martinez-Perez A., Karamarkovic A. R., Osipov A. V., Coppola A., Cucchetti A., Spolini A., Giordano A., Reinisch-Liese A., Kavalakat A. J., Vasilescu A., Alamin A., Gupta A., Dascalu A. M., Musina A. -M., Bakopoulos A., Zakaria A. D., Vereczkei A., Balla A., Bottari A., Baumann A., Fette A., Litvin A., Reichert A. K., Guariniello A., Paspala A., Schneck A. -S., Brillantino A., Pesce A., Isik A., Leppaniemi A. K., Papadopoulos A., Kechagias A., Mohamed A. Y. A., Mitul A. R., Marinis A., Syllaios A., Mantoglu B., De Simone B., Weiss B. S., Posentrup B., Picardi B., Zampogna B., Sakakushev B. E., Atanasov B. C., Nardo B., Calik B., Cremonini C., Ordonez C. A., Seretis C., Cascone C., Chouliaras C., Bendinelli C., Lopes C., Guerci C., Weber C., Nastos C., Mesina C., Caputo D., Massalou D., Cavaliere D., McNamara D. A., Demetriades D., Pantalone D., Coletta D., Sasia D., Visconti D., Weber D. G., Corallino D., Chatzipetris D., Manatakis D. K., Ntourakis D., Papaconstantinou D., Schizas D., Chrysikos D., Adamovich D. M., Elkafrawy D., Seban D., Garcia E. F. H., Baldini E., Picetti E., Tan E. C. T. H., Baili E., Lostoridis E., Toma E. A., Colak E., Cerutti E., Steyn E., Hsabo E. A., Kapetanakis E. I., Kaouras E., Schneck E., Akin E., Gonullu E., celik E., Cicuttin E., Pinotti E., Johnsson E., Moore E. E., Agastra E., Dimitrov E. N., Griffiths E. A., D'Acapito F., Saraceno F., Alconchel F., Zeppernick F. A., Rodriguez F. M., Abu-Zidan F., Pecchini F., Favi F., Ferrara F., Fleres F., Pata F., Roscio F. P. M., Mulita F., Dor F. J. M. F., Linder F., Dimofte G., Rodrigues G., Nita G., Sganga G., Martines G., Mazzarella G., Perrone G., Velmahos G., Lianos G. D., Tomadze G., Baiocchi G. L., D'Ambrosio G., Pellino G., Pattacini G. C., Giraudo G., Lisi G., Tebala G. D., Pirozzolo G., Montori G., Argenio G., Brisinda G., Curro G., Giuliani G., Palomba G., Roscitano G., Avsar G., Augustin G., Clarizia G., Vega G. M. M., Fraga G. P., Sethi H., Eltyeb H. A., Lohse H. A. S., Lohse H. R. S., Bayhan H., Hamid H. K. S., Kryvoruchko I. A., Iannone I., Wani I., Lazaridis I. I., Katsaros I., Nikolopoulos I., Negoi I., Reccia I., Di Carlo I., Olaoye I. O., Czepiel J., Kim J. I., Meyer J., Terrazas J. M. S., Tochie J. N., Galante J. M., Davies J., Sugand K., Gonfa K. B., Rasa K., Kok K. Y. Y., Apostolou K. G., Lasithiotakis K., Tsekouras K., Angamuthu K., Akhmeteli L., Sydorchuk L., Fortuna L., Siragusa L., Pagani L., Solaini L., Miller L. A., Bains L., Ansaloni L., Ferrario L., Bonavina L., Conti L., Buonomo L. A., Tallon-Aguilar L., Tomczyk L., Widmer L. W., Waledziak M., Gachabayov M., Bulanauca M. M., Malbrain M. L. N. G., Maegele M., Catarci M., Ceresoli M., Ranucci M. C., Antonopoulou M. I., Papadoliopoulou M., Valenti M. R., Sotiropoulou M., D'Oria M., Martin M. S., Hirschburger M., Veroux M., Fantoni M., Nardi M., Tolonen M., Montuori M., Podda M., Scheiterle M., Frountzas M., Sarikaya M., Yildirim M., Bender M., Vailas M., Teuben M., Campanelli M., Ammendola M., Malerba M., Pisano M., Pertea M., Slavchev M., Ukkonen M., Bala M., Chirica M., Barone M., Shaat M. M., Mohammed M. J. S., Abuelgasim M. A. A., Gureh M., Ouadii M., Balkan M., Mohamed M., Hakseven M., Velenciuc N., Cillara N., de'Angelis N., Tamini N., Zavras N. J., Machairas N., Michalopoulos N., Koliakos N. N., Pararas N., Donlon N. E., Medappil N., Ben-Ishay O., Stefano O., Islam O., Tammo O., Ioannidis O., Aparicio O., Baraket O., Kumar P., Cianci P., Ortenwall P., Uchikov P. A., de Reuver P., Stahel P. F., Barie P. S., Piccoli M., Major P., Navsaria P. H., Sasmal P. K., Coimbra R., Rahim R., Capoglu R., Koshy R. M., Gonsaga R. A. T., Pertile R., Mohamed R. R. M., Deryol R., Sawyer R. G., Angelico R., Ragozzino R., Bini R., Cammarata R., Scaramuzzo R., Gioco R., Sydorchuk R., Ahmed S., Di Saverio S., Emile S. H., Delibegovic S., Marwah S., Symeonidis S., Thomas S. G., Demir S., Awad S. S., Atici S. D., Chooklin S., Meric S., Sarikaya S., Chowdhury S., Mirghani S. F., Wren S. M., Gargarella S., Del Monte S. R., Esposito S., Xenaki S., Mohamed S. F. G., Beka S. G., Lunca S., Delis S. G., Dritsas S., Morarasu S., Magnone S., Rossi S., Bitsianis S., Kykalos S., Baral S., Jain S. A., Ali S. M., Pintar T., Triantafyllou T., Delko T., Perra T., Sidiropoulos T. A., Scalea T. M., Vilz T. O., Hardcastle T. C., Wannatoop T., Herzog T., Mishra T. S., Boggi U., Calu V., Tomajer V., Agnoletti V., Lohsiriwat V., Kong V., Munoz-Cruzado V. D., Shelat V. G., Khokha V., Ghannam W. M., Biffl W. L., Zuidema W., Kara Y., Kobe Y., Demetrashvili Z., Memish Z. A., Madrazo Z., Balogh Z. J., and Bayhan Z.
- Abstract
Background: The SARS-CoV-2 pandemic is still ongoing and a major challenge for health care services worldwide. In the first WSES COVID-19 emergency surgery survey, a strong negative impact on emergency surgery (ES) had been described already early in the pandemic situation. However, the knowledge is limited about current effects of the pandemic on patient flow through emergency rooms, daily routine and decision making in ES as well as their changes over time during the last two pandemic years. This second WSES COVID-19 emergency surgery survey investigates the impact of the SARS-CoV-2 pandemic on ES during the course of the pandemic. Methods: A web survey had been distributed to medical specialists in ES during a four-week period from January 2022, investigating the impact of the pandemic on patients and septic diseases both requiring ES, structural problems due to the pandemic and time-to-intervention in ES routine. Results: 367 collaborators from 59 countries responded to the survey. The majority indicated that the pandemic still significantly impacts on treatment and outcome of surgical emergency patients (83.1% and 78.5%, respectively). As reasons, the collaborators reported decreased case load in ES (44.7%), but patients presenting with more prolonged and severe diseases, especially concerning perforated appendicitis (62.1%) and diverticulitis (57.5%). Otherwise, approximately 50% of the participants still observe a delay in time-to-intervention in ES compared with the situation before the pandemic. Relevant causes leading to enlarged time-to-intervention in ES during the pandemic are persistent problems with in-hospital logistics, lacks in medical staff as well as operating room and intensive care capacities during the pandemic. This leads not only to the need for triage or transferring of ES patients to other hospitals, reported by 64.0% and 48.8% of the collaborators, respectively, but also to paradigm shifts in treatment modalities to non-operative approach
- Published
- 2022
3. Evolving Trends in the Management of Acute Appendicitis During COVID-19 Waves: The ACIE Appy II Study
- Author
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Pata, F, Di Martino, M, Podda, M, Di Saverio, S, Ielpo, B, Pellino, G, Julio, A, Alshamrani, A, Alturkistani, A, Alghamdi, A, Almalki, A, Orengia, A, Kuvvetli, A, Pisanu, A, Smith, A, Trevino Figueroa, A, Nacion, A, Alhazmi, A, Bouhuwaish, A, Khalid, A, Alsufyani, A, Rubio, A, Bavikatte, A, Kumar, A, Jamiri, A, de San Ildefonso Pereira, A, Porcu, A, Sartori, A, Rocca, A, Sretenovic, A, Anselmo, A, De Luca, A, Charalabopoulos, A, Tzivanakis, A, Bandin, A, Najar, A, Frontali, A, Faisal, A, Roldan, A, Hamid, A, Andre, A, Minaya-Bravo, A, Das, A, Bondurri, A, Costanzi, A, Lucchi, A, Mihailescu, A, Police, A, Zuchini, A, Romano, A, Iossa, A, Chessa, A, Tromba, A, Castaldi, A, Brillantino, A, Ferronetti, A, Giuliani, A, Ramos-De la Medina, A, Tarasconi, A, Picciariello, A, Ioannidis, A, Leppaniemi, A, Rashid, A, Mitul, A, Mehraj, A, Laharwal, A, Iqbal, A, Liarakos, A, Marinis, A, de Andres-Asenjo, B, Matias-Garcia, B, De Simone, B, Creavin, B, Stubbs, B, Goh, B, Jovanovic, B, Sensi, B, Gazia, C, Cerdan, C, Diaz, C, Chacon, C, Yanez, C, Faro, C, Reinke, C, Dominguez, C, Paranjape, C, Thomas, C, Fung, C, De Lucia, C, Jennifer, C, Ovalle-Chao, C, Guerci, C, Kenington, C, Gica, C, Folliero, C, Varela, C, Popowich, D, Delogu, D, Zigiotto, D, Vinci, D, D'Antonio, D, Merlini, D, Moro-Valdezate, D, Keller, D, Nicolaescu, D, Sasia, D, Rodas, E, Linardoutsos, D, Russello, D, Najar-Castaneda, P, Stavrou, H, Rosso, E, Saladino, E, Ricciardi, E, Smith-Singares, E, Baili, E, Douka, E, Guaitoli, E, Francone, E, Vaterlini, E, Pierobon, E, Morales, E, Ros, E, Benzoni, E, Erdas, E, Pinotti, E, Colas-Ruiz, E, Laterza, E, Foianini, E, Cardamone, E, Licardie, E, Marino, F, Alsofyani, F, Qahtani, F, Khan, F, Maraska, F, Saliu, F, Madrid, F, Rosa, F, Luvisetto, F, Alconchel, F, Pareja-Ciuro, F, Neves, F, Agresta, F, Cordera, F, Pardo, F, Mendoza-Moreno, F, Munoz-Flores, F, Silvestri, F, Tropeano, F, Pecchini, F, Serio, F, Colombo, F, Di Marzo, F, Ferrara, F, Lancellotti, F, Litta, F, Martini, F, Roscio, F, Blanco-Antona, F, Barcenas, F, Schlottmann, F, Herrera-Almario, G, van Ramshorst, G, Gallo, G, Luglio, G, Kampouroglou, G, Papadopoulos, G, Arredondo, G, Calini, G, Formisano, G, Galiffa, G, Palini, G, Colucci, G, Pagano, G, Vanni, G, Pattacini, G, Gravante, G, Lisi, G, Bellanova, G, De Nobili, G, Necchi, G, Sinibaldi, G, Bacchiocchi, G, Bagaglini, G, Maggi, G, Izzo, G, Argenio, G, Brisinda, G, Esposito, G, Frazzetta, G, De Luca, G, Nigri, G, Sica, G, Martin-Martin, G, Ugon, G, Martinez-Mier, G, Machain Vega, G, Nari, G, Nikaj, H, Neri, I, San Roman, I, Fidoshev, I, Martinez, I, Negoi, I, Ortega, I, Vicente Rodriguez, I, Cornejo, I, Mora-Guzman, I, al-Najami, I, Romic, I, Balciscueta, I, Olivier, J, Lammel-Lindemann, J, Dziakova, J, Salinas, J, Jovanovic, J, Reyes, J, Salas, J, Diaz-Elizondo, J, Parreira, J, Bellido, J, Salamea, J, Martin del Olmo, J, Ordonez, J, Junaid, S, Davies, J, Sahnan, K, Bekele, K, Voon, K, Siragusa, L, Petagna, L, Ferrario, L, Giordano, L, Nespoli, L, Pio, L, Moletta, L, Curella, L, Taglietti, L, Bonavina, L, Conti, L, Perez-Sanchez, L, Cabrera Vargas, L, Sanchez-Guillen, L, Tallon-Aguilar, L, Khan, M, Spampinato, M, Viola, M, Malet, M, Angrisani, M, Calussi, M, Catarci, M, Giordano, M, Materazzo, M, Milone, M, Pellicciaro, M, Marino, M, Moreno Villamizar, M, Lolli, M, Bellini, M, Lemma, M, Chiarello, M, Montes-Manrique, M, Rodriguez-Lopez, M, Serradilla-Martin, M, Peter, M, Paniagua-Garcia-Senorans, M, Rutegard, M, Salo, M, Silveri, M, Veroux, M, Nardi, M, Rottoli, M, Tolonen, M, Pedraza Ciro, M, Zuluaga, M, Iacobone, M, Montuori, M, Ali, M, Garcia Dominguez, M, Paola, M, Piccoli, M, Campanelli, M, De Rosa, M, Manigrasso, M, Maruccia, M, Torre, M, Zuolo, M, Pera, M, Weerasekera, M, Prieto, M, Thway, M, Shaat, M, Azfar, M, Shalaby, M, Raza, M, Younis, M, Elhadi, M, Althomali, M, Al Amri, N, Dudi-Venkata, N, Alselaim, N, Smart, N, Trelles, N, Falco, N, Petrucciani, N, Antonacci, N, Cillara, N, Gica, N, Pecorelli, N, Tamini, N, Machairas, N, Feituri, N, Ortega Torrecilla, N, Avila Mercado, O, Alaamer, O, Irkorucu, O, Alsherif, O, Buonomi, O, Valles-Guerra, O, Ioannidis, O, Hernandez Palmas, O, Sanz Guadarrama, O, Bozbiyik, O, Rodrigues, P, Milito, P, Panaccio, P, Dorovinis, P, Prieto, P, Baroffio, P, Marsanic, P, Ajawin, P, Koh, P, Anoldo, P, Major, P, Alharthi, Q, Lui, R, Caruso, R, Brady, R, Rattan, R, Singhal, R, Angelico, R, Isernia, R, Tutino, R, Peltrini, R, Tejos, R, Fajardo, R, Elia, R, Morales-Conde, S, Benli, S, Fuentes, S, de las Casas, S, de Guzman Aragon, S, Vertaldi, S, Awad, S, Gentilli, S, Weckmann Lujan, S, Tayar, S, Althobaiti, S, Di Giovanni, S, Ghedan, S, Perez-Bertolez, S, Chiappetta, S, Delis, S, Scaringi, S, Cetinkunar, S, Kykalos, S, Muhammad Ali, S, Krivan, S, Fung, T, Delko, T, Nicolas Lopez, T, De Campos, T, Calderon Duque, T, Perra, T, Liakakos, T, Daskalakis, T, Koeter, T, Zalla, T, Gonzalez, T, Campagnaro, T, Oumar, T, Grossi, U, Sosa, V, Testa, V, Tomajer, V, Andriola, V, Tonini, V, Celentano, V, Voglino, V, Katta, V, Garcia Orozco, V, Turrado-Rodriguez, V, Visag-Castillo, V, Graham, V, Rachkov, V, Papagni, V, Vigorita, V, Jimenez Carneros, V, Bellato, V, Bechstein, W, Altinel, Y, Balciscueta, Z, Pata F., Di Martino M., Podda M., Di Saverio S., Ielpo B., Pellino G., Julio A., Alshamrani A., Alturkistani A., Alghamdi A., Almalki A., Orengia A., Kuvvetli A., Pisanu A., Smith A., Trevino Figueroa A. M., Nacion A. J., Alhazmi A., Bouhuwaish A., Khalid A., Alsufyani A., Rubio A. V., Bavikatte A., Kumar A., Jamiri A. -R., de San Ildefonso Pereira A., Porcu A., Sartori A., Rocca A., Sretenovic A., Anselmo A., De Luca A., Charalabopoulos A., Tzivanakis A., Bandin A., Najar A., Frontali A., Faisal A., Roldan A. M., Hamid A., Andre A., Minaya-Bravo A., Das A., Bondurri A., Costanzi A., Lucchi A., Mihailescu A., Police A., Zuchini A. M., Romano A., Iossa A., Chessa A., Tromba A., Castaldi A., Brillantino A., Ferronetti A., Giuliani A., Ramos-De la Medina A., Tarasconi A., Picciariello A., Ioannidis A., Leppaniemi A., Rashid A., Mitul A. R., Mehraj A., laharwal A., Iqbal A., Liarakos A., Marinis A., de Andres-Asenjo B., Matias-Garcia B., De Simone B., Creavin B., Stubbs B., Goh B., Jovanovic B., Sensi B., Gazia C., Cerdan C., Diaz C. J. G., Chacon C. P., Yanez C., Faro C. L., Reinke C., Dominguez C., Paranjape C., Thomas C., Fung C. C., De Lucia C., Jennifer C. H. F., Ovalle-Chao C., Guerci C., Kenington C., Gica C., Folliero C., Varela C., Popowich D., Delogu D., Zigiotto D., Vinci D., D'Antonio D., Merlini D. A., Merlini D., Moro-Valdezate D., Keller D., Nicolaescu D. C., Sasia D., Rodas E., Linardoutsos D., Russello D., Najar-Castaneda P. A., Stavrou H. G., Rosso E., Saladino E., Ricciardi E., Smith-Singares E., Baili E., Douka E., Guaitoli E., Francone E., Vaterlini E. M., Pierobon E. S., Morales E., Ros E. P., Benzoni E., Erdas E., Pinotti E., Colas-Ruiz E., Laterza E., Foianini E., Cardamone E., Licardie E., Marino F., Alsofyani F., Qahtani F., Khan F., Maraska F., Saliu F., Madrid F., Rosa F., Luvisetto F., Alconchel F., Pareja-Ciuro F., Neves F., Agresta F., Cordera F., Pardo F., Mendoza-Moreno F., Munoz-Flores F., Silvestri F. M., Tropeano F. P., Pecchini F., Serio F., Colombo F., Di Marzo F., Ferrara F., Lancellotti F., Litta F., Martini F., Roscio F., Blanco-Antona F., Barcenas F. J. Q., Schlottmann F., Herrera-Almario G., van Ramshorst G., Gallo G., Luglio G., Kampouroglou G., Papadopoulos G., Arredondo G., Calini G., Formisano G., Galiffa G., Palini G. M., Colucci G., Pagano G., Vanni G., Pattacini G. C., Gravante G., Lisi G., Bellanova G., De Nobili G., Necchi G. S., Sinibaldi G., Bacchiocchi G., Bagaglini G., Maggi G., Izzo G., Argenio G., Brisinda G., Esposito G., Frazzetta G., De Luca G. M., Nigri G., Sica G., Martin-Martin G., Ugon G. A., Martinez-Mier G., Machain Vega G. M., Nari G., Nikaj H., Neri I., San Roman I. A., Fidoshev I., Martinez I., Negoi I., Ortega I., Vicente Rodriguez I., Cornejo I., Mora-Guzman I., al-Najami I., Romic I., Balciscueta I., Olivier J., Lammel-Lindemann J., Dziakova J., Salinas J., Jovanovic J. P., Reyes J. A. S., Salas J., Diaz-Elizondo J. A., Parreira J. G., Bellido J., Salamea J., Martin del Olmo J. C., Ordonez J. M., Junaid S., Davies J., Sahnan K., Bekele K., Voon K., Siragusa L., Petagna L., Ferrario L., Giordano L., Nespoli L., Pio L., Moletta L., Curella L., Taglietti L., Bonavina L., Conti L., Perez-Sanchez L. E., Cabrera Vargas L. F., Sanchez-Guillen L., Tallon-Aguilar L., Khan M., Spampinato M. G., Viola M., Malet M. V., Angrisani M., Calussi M., Catarci M., Giordano M., Materazzo M., Milone M., Pellicciaro M., Marino M. V., Moreno Villamizar M. D., Lolli M. G., Bellini M. I., Lemma M., Chiarello M. M., Montes-Manrique M., Rodriguez-Lopez M., Serradilla-Martin M., Peter M., Paniagua-Garcia-Senorans M., Rutegard M., Salo M., Silveri M., Veroux M., Nardi M., Rottoli M., Tolonen M., Pedraza Ciro M., Zuluaga M., Iacobone M., Montuori M., Ali M., Garcia Dominguez M., Paola M. M., Piccoli M., Campanelli M., De Rosa M., Manigrasso M., Maruccia M., Torre M., Zuolo M., Pera M., Weerasekera M., Prieto M., Thway M. M., Shaat M., Azfar M., Shalaby M., Raza M. A., Younis M. U., Elhadi M., AlThomali M., Al Amri N., Dudi-Venkata N., Alselaim N., Smart N., Trelles N., Falco N., Petrucciani N., Antonacci N., Cillara N., Gica N., Pecorelli N., Tamini N., Machairas N., Feituri N., Ortega Torrecilla N., Avila Mercado O., AlAamer O., Irkorucu O., Alsherif O., Buonomi O. C., Valles-Guerra O., Ioannidis O., Hernandez Palmas O. I., Sanz Guadarrama O., Bozbiyik O., Rodrigues P., Milito P., Panaccio P., Dorovinis P., Prieto P., Baroffio P., Marsanic P., Ajawin P., Koh P. S., Anoldo P., Major P., Alharthi Q., Lui R., Caruso R., Brady R., Rattan R., Singhal R., Angelico R., Isernia R. M., Tutino R., Peltrini R., Tejos R., Fajardo R., Elia R., Morales-Conde S., Benli S., Fuentes S., de las Casas S. G., de Guzman Aragon S. O., Vertaldi S., Awad S., Gentilli S., Weckmann Lujan S. A., Tayar S., Althobaiti S., Di Giovanni S., Ghedan S., Perez-Bertolez S., Chiappetta S., Delis S., Scaringi S., Cetinkunar S., Kykalos S., Muhammad Ali S., Krivan S., Fung T. L. D., Delko T., Nicolas Lopez T., De Campos T., Calderon Duque T., Perra T., Liakakos T., Daskalakis T., Koeter T., Zalla T., Gonzalez T. E., Campagnaro T., Oumar T. A., Grossi U., Sosa V., Testa V., Tomajer V., Andriola V., Tonini V., Celentano V., Voglino V., Katta V. R., Garcia Orozco V. 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F, Pardo, F, Mendoza-Moreno, F, Munoz-Flores, F, Silvestri, F, Tropeano, F, Pecchini, F, Serio, F, Colombo, F, Di Marzo, F, Ferrara, F, Lancellotti, F, Litta, F, Martini, F, Roscio, F, Blanco-Antona, F, Barcenas, F, Schlottmann, F, Herrera-Almario, G, van Ramshorst, G, Gallo, G, Luglio, G, Kampouroglou, G, Papadopoulos, G, Arredondo, G, Calini, G, Formisano, G, Galiffa, G, Palini, G, Colucci, G, Pagano, G, Vanni, G, Pattacini, G, Gravante, G, Lisi, G, Bellanova, G, De Nobili, G, Necchi, G, Sinibaldi, G, Bacchiocchi, G, Bagaglini, G, Maggi, G, Izzo, G, Argenio, G, Brisinda, G, Esposito, G, Frazzetta, G, De Luca, G, Nigri, G, Sica, G, Martin-Martin, G, Ugon, G, Martinez-Mier, G, Machain Vega, G, Nari, G, Nikaj, H, Neri, I, San Roman, I, Fidoshev, I, Martinez, I, Negoi, I, Ortega, I, Vicente Rodriguez, I, Cornejo, I, Mora-Guzman, I, al-Najami, I, Romic, I, Balciscueta, I, Olivier, J, Lammel-Lindemann, J, Dziakova, J, Salinas, J, Jovanovic, J, Reyes, J, Salas, J, Diaz-Elizondo, J, Parreira, J, Bellido, J, Salamea, J, Martin del Olmo, J, Ordonez, J, Junaid, S, Davies, J, Sahnan, K, Bekele, K, Voon, K, Siragusa, L, Petagna, L, Ferrario, L, Giordano, L, Nespoli, L, Pio, L, Moletta, L, Curella, L, Taglietti, L, Bonavina, L, Conti, L, Perez-Sanchez, L, Cabrera Vargas, L, Sanchez-Guillen, L, Tallon-Aguilar, L, Khan, M, Spampinato, M, Viola, M, Malet, M, Angrisani, M, Calussi, M, Catarci, M, Giordano, M, Materazzo, M, Milone, M, Pellicciaro, M, Marino, M, Moreno Villamizar, M, Lolli, M, Bellini, M, Lemma, M, Chiarello, M, Montes-Manrique, M, Rodriguez-Lopez, M, Serradilla-Martin, M, Peter, M, Paniagua-Garcia-Senorans, M, Rutegard, M, Salo, M, Silveri, M, Veroux, M, Nardi, M, Rottoli, M, Tolonen, M, Pedraza Ciro, M, Zuluaga, M, Iacobone, M, Montuori, M, Ali, M, Garcia Dominguez, M, Paola, M, Piccoli, M, Campanelli, M, De Rosa, M, Manigrasso, M, Maruccia, M, Torre, M, Zuolo, M, Pera, M, Weerasekera, M, Prieto, M, Thway, M, Shaat, M, Azfar, M, Shalaby, M, Raza, M, Younis, M, Elhadi, M, Althomali, M, Al Amri, N, Dudi-Venkata, N, Alselaim, N, Smart, N, Trelles, N, Falco, N, Petrucciani, N, Antonacci, N, Cillara, N, Gica, N, Pecorelli, N, Tamini, N, Machairas, N, Feituri, N, Ortega Torrecilla, N, Avila Mercado, O, Alaamer, O, Irkorucu, O, Alsherif, O, Buonomi, O, Valles-Guerra, O, Ioannidis, O, Hernandez Palmas, O, Sanz Guadarrama, O, Bozbiyik, O, Rodrigues, P, Milito, P, Panaccio, P, Dorovinis, P, Prieto, P, Baroffio, P, Marsanic, P, Ajawin, P, Koh, P, Anoldo, P, Major, P, Alharthi, Q, Lui, R, Caruso, R, Brady, R, Rattan, R, Singhal, R, Angelico, R, Isernia, R, Tutino, R, Peltrini, R, Tejos, R, Fajardo, R, Elia, R, Morales-Conde, S, Benli, S, Fuentes, S, de las Casas, S, de Guzman Aragon, S, Vertaldi, S, Awad, S, Gentilli, S, Weckmann Lujan, S, Tayar, S, Althobaiti, S, Di Giovanni, S, Ghedan, S, Perez-Bertolez, S, Chiappetta, S, Delis, S, Scaringi, S, Cetinkunar, S, Kykalos, S, Muhammad Ali, S, Krivan, S, Fung, T, Delko, T, Nicolas Lopez, T, De Campos, T, Calderon Duque, T, Perra, T, Liakakos, T, Daskalakis, T, Koeter, T, Zalla, T, Gonzalez, T, Campagnaro, T, Oumar, T, Grossi, U, Sosa, V, Testa, V, Tomajer, V, Andriola, V, Tonini, V, Celentano, V, Voglino, V, Katta, V, Garcia Orozco, V, Turrado-Rodriguez, V, Visag-Castillo, V, Graham, V, Rachkov, V, Papagni, V, Vigorita, V, Jimenez Carneros, V, Bellato, V, Bechstein, W, Altinel, Y, Balciscueta, Z, Pata F., Di Martino M., Podda M., Di Saverio S., Ielpo B., Pellino G., Julio A., Alshamrani A., Alturkistani A., Alghamdi A., Almalki A., Orengia A., Kuvvetli A., Pisanu A., Smith A., Trevino Figueroa A. M., Nacion A. J., Alhazmi A., Bouhuwaish A., Khalid A., Alsufyani A., Rubio A. V., Bavikatte A., Kumar A., Jamiri A. -R., de San Ildefonso Pereira A., Porcu A., Sartori A., Rocca A., Sretenovic A., Anselmo A., De Luca A., Charalabopoulos A., Tzivanakis A., Bandin A., Najar A., Frontali A., Faisal A., Roldan A. M., Hamid A., Andre A., Minaya-Bravo A., Das A., Bondurri A., Costanzi A., Lucchi A., Mihailescu A., Police A., Zuchini A. M., Romano A., Iossa A., Chessa A., Tromba A., Castaldi A., Brillantino A., Ferronetti A., Giuliani A., Ramos-De la Medina A., Tarasconi A., Picciariello A., Ioannidis A., Leppaniemi A., Rashid A., Mitul A. R., Mehraj A., laharwal A., Iqbal A., Liarakos A., Marinis A., de Andres-Asenjo B., Matias-Garcia B., De Simone B., Creavin B., Stubbs B., Goh B., Jovanovic B., Sensi B., Gazia C., Cerdan C., Diaz C. J. G., Chacon C. P., Yanez C., Faro C. L., Reinke C., Dominguez C., Paranjape C., Thomas C., Fung C. C., De Lucia C., Jennifer C. H. F., Ovalle-Chao C., Guerci C., Kenington C., Gica C., Folliero C., Varela C., Popowich D., Delogu D., Zigiotto D., Vinci D., D'Antonio D., Merlini D. A., Merlini D., Moro-Valdezate D., Keller D., Nicolaescu D. C., Sasia D., Rodas E., Linardoutsos D., Russello D., Najar-Castaneda P. A., Stavrou H. G., Rosso E., Saladino E., Ricciardi E., Smith-Singares E., Baili E., Douka E., Guaitoli E., Francone E., Vaterlini E. M., Pierobon E. S., Morales E., Ros E. P., Benzoni E., Erdas E., Pinotti E., Colas-Ruiz E., Laterza E., Foianini E., Cardamone E., Licardie E., Marino F., Alsofyani F., Qahtani F., Khan F., Maraska F., Saliu F., Madrid F., Rosa F., Luvisetto F., Alconchel F., Pareja-Ciuro F., Neves F., Agresta F., Cordera F., Pardo F., Mendoza-Moreno F., Munoz-Flores F., Silvestri F. M., Tropeano F. P., Pecchini F., Serio F., Colombo F., Di Marzo F., Ferrara F., Lancellotti F., Litta F., Martini F., Roscio F., Blanco-Antona F., Barcenas F. J. Q., Schlottmann F., Herrera-Almario G., van Ramshorst G., Gallo G., Luglio G., Kampouroglou G., Papadopoulos G., Arredondo G., Calini G., Formisano G., Galiffa G., Palini G. M., Colucci G., Pagano G., Vanni G., Pattacini G. C., Gravante G., Lisi G., Bellanova G., De Nobili G., Necchi G. S., Sinibaldi G., Bacchiocchi G., Bagaglini G., Maggi G., Izzo G., Argenio G., Brisinda G., Esposito G., Frazzetta G., De Luca G. M., Nigri G., Sica G., Martin-Martin G., Ugon G. A., Martinez-Mier G., Machain Vega G. M., Nari G., Nikaj H., Neri I., San Roman I. A., Fidoshev I., Martinez I., Negoi I., Ortega I., Vicente Rodriguez I., Cornejo I., Mora-Guzman I., al-Najami I., Romic I., Balciscueta I., Olivier J., Lammel-Lindemann J., Dziakova J., Salinas J., Jovanovic J. P., Reyes J. A. S., Salas J., Diaz-Elizondo J. A., Parreira J. G., Bellido J., Salamea J., Martin del Olmo J. C., Ordonez J. M., Junaid S., Davies J., Sahnan K., Bekele K., Voon K., Siragusa L., Petagna L., Ferrario L., Giordano L., Nespoli L., Pio L., Moletta L., Curella L., Taglietti L., Bonavina L., Conti L., Perez-Sanchez L. E., Cabrera Vargas L. F., Sanchez-Guillen L., Tallon-Aguilar L., Khan M., Spampinato M. G., Viola M., Malet M. V., Angrisani M., Calussi M., Catarci M., Giordano M., Materazzo M., Milone M., Pellicciaro M., Marino M. V., Moreno Villamizar M. D., Lolli M. G., Bellini M. I., Lemma M., Chiarello M. M., Montes-Manrique M., Rodriguez-Lopez M., Serradilla-Martin M., Peter M., Paniagua-Garcia-Senorans M., Rutegard M., Salo M., Silveri M., Veroux M., Nardi M., Rottoli M., Tolonen M., Pedraza Ciro M., Zuluaga M., Iacobone M., Montuori M., Ali M., Garcia Dominguez M., Paola M. M., Piccoli M., Campanelli M., De Rosa M., Manigrasso M., Maruccia M., Torre M., Zuolo M., Pera M., Weerasekera M., Prieto M., Thway M. M., Shaat M., Azfar M., Shalaby M., Raza M. A., Younis M. U., Elhadi M., AlThomali M., Al Amri N., Dudi-Venkata N., Alselaim N., Smart N., Trelles N., Falco N., Petrucciani N., Antonacci N., Cillara N., Gica N., Pecorelli N., Tamini N., Machairas N., Feituri N., Ortega Torrecilla N., Avila Mercado O., AlAamer O., Irkorucu O., Alsherif O., Buonomi O. C., Valles-Guerra O., Ioannidis O., Hernandez Palmas O. I., Sanz Guadarrama O., Bozbiyik O., Rodrigues P., Milito P., Panaccio P., Dorovinis P., Prieto P., Baroffio P., Marsanic P., Ajawin P., Koh P. S., Anoldo P., Major P., Alharthi Q., Lui R., Caruso R., Brady R., Rattan R., Singhal R., Angelico R., Isernia R. M., Tutino R., Peltrini R., Tejos R., Fajardo R., Elia R., Morales-Conde S., Benli S., Fuentes S., de las Casas S. G., de Guzman Aragon S. O., Vertaldi S., Awad S., Gentilli S., Weckmann Lujan S. A., Tayar S., Althobaiti S., Di Giovanni S., Ghedan S., Perez-Bertolez S., Chiappetta S., Delis S., Scaringi S., Cetinkunar S., Kykalos S., Muhammad Ali S., Krivan S., Fung T. L. D., Delko T., Nicolas Lopez T., De Campos T., Calderon Duque T., Perra T., Liakakos T., Daskalakis T., Koeter T., Zalla T., Gonzalez T. E., Campagnaro T., Oumar T. A., Grossi U., Sosa V., Testa V., Tomajer V., Andriola V., Tonini V., Celentano V., Voglino V., Katta V. R., Garcia Orozco V. H., Turrado-Rodriguez V., Visag-Castillo V., Graham V., Rachkov V., Papagni V., Vigorita V., Jimenez Carneros V., Bellato V., Bechstein W., Altinel Y., and Balciscueta Z.
- Abstract
Background: In 2020, ACIE Appy study showed that COVID-19 pandemic heavily affected the management of patients with acute appendicitis (AA) worldwide, with an increased rate of non-operative management (NOM) strategies and a trend toward open surgery due to concern of virus transmission by laparoscopy and controversial recommendations on this issue. The aim of this study was to survey again the same group of surgeons to assess if any difference in management attitudes of AA had occurred in the later stages of the outbreak. Methods: From August 15 to September 30, 2021, an online questionnaire was sent to all 709 participants of the ACIE Appy study. The questionnaire included questions on personal protective equipment (PPE), local policies and screening for SARS-CoV-2 infection, NOM, surgical approach and disease presentations in 2021. The results were compared with the results from the previous study. Results: A total of 476 answers were collected (response rate 67.1%). Screening policies were significatively improved with most patients screened regardless of symptoms (89.5% vs. 37.4%) with PCR and antigenic test as the preferred test (74.1% vs. 26.3%). More patients tested positive before surgery and commercial systems were the preferred ones to filter smoke plumes during laparoscopy. Laparoscopic appendicectomy was the first option in the treatment of AA, with a declined use of NOM. Conclusion: Management of AA has improved in the last waves of pandemic. Increased evidence regarding SARS-COV-2 infection along with a timely healthcare systems response has been translated into tailored attitudes and a better care for patients with AA worldwide.
- Published
- 2022
4. Correction: Evolving Trends in the Management of Acute Appendicitis During COVID-19 Waves: The ACIE Appy II Study (World Journal of Surgery, (2022), 46, 9, (2021-2035), 10.1007/s00268-022-06649-z)
- Author
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Pata F., Pata, F, Di Martino, M, Podda, M, Di Saverio, S, Ielpo, B, Pellino, G, Julio, A, Alshamrani, A, Alturkistani, A, Alghamdi, A, Almalki, A, Orengia, A, Kuvvetli, A, Pisanu, A, Smith, A, Trevino Figueroa, A, Nacion, A, Alhazmi, A, Bouhuwaish, A, Khalid, A, Alsufyani, A, Rubio, A, Bavikatte, A, Kumar, A, Jamiri, A, de San Ildefonso Pereira, A, Porcu, A, Sartori, A, Rocca, A, Sretenovic, A, Anselmo, A, De Luca, A, Charalabopoulos, A, Tzivanakis, A, Bandin, A, Najar, A, Frontali, A, Faisal, A, Roldan, A, Hamid, A, Andre, A, Minaya-Bravo, A, Das, A, Bondurri, A, Costanzi, A, Lucchi, A, Mihailescu, A, Police, A, Zuchini, A, Romano, A, Iossa, A, Chessa, A, Tromba, A, Castaldi, A, Brillantino, A, Ferronetti, A, Giuliani, A, Ramos-De la Medina, A, Tarasconi, A, Picciariello, A, Ioannidis, A, Leppaniemi, A, Rashid, A, Mitul, A, Mehraj, A, Laharwal, A, Iqbal, A, Liarakos, A, Marinis, A, de Andres-Asenjo, B, Matias-Garcia, B, De Simone, B, Creavin, B, Stubbs, B, Goh, B, Jovanovic, B, Sensi, B, Gazia, C, Cerdan, C, Diaz, C, Chacon, C, Yanez, C, Faro, C, Reinke, C, Dominguez, C, Paranjape, C, Thomas, C, Fung, C, De Lucia, C, Jennifer, C, Ovalle-Chao, C, Guerci, C, Kenington, C, Gica, C, Folliero, C, Varela, C, Popowich, D, Delogu, D, Zigiotto, D, Vinci, D, D'Antonio, D, Merlini, D, Moro-Valdezate, D, Keller, D, Nicolaescu, D, Sasia, D, Rodas, E, Linardoutsos, D, Russello, D, Najar-Castaneda, P, Stavrou, H, Rosso, E, Saladino, E, Ricciardi, E, Smith-Singares, E, Baili, E, Douka, E, Guaitoli, E, Francone, E, Vaterlini, E, Pierobon, E, Morales, E, Ros, E, Benzoni, E, Erdas, E, Pinotti, E, Colas-Ruiz, E, Laterza, E, Foianini, E, Cardamone, E, Licardie, E, Marino, F, Alsofyani, F, Qahtani, F, Khan, F, Maraska, F, Saliu, F, Madrid, F, Rosa, F, Luvisetto, F, Alconchel, F, Pareja-Ciuro, F, Neves, F, Agresta, F, Cordera, F, Pardo, F, Mendoza-Moreno, F, Munoz-Flores, F, Silvestri, F, Tropeano, F, Pecchini, F, Serio, F, Colombo, F, Di Marzo, F, Ferrara, F, Lancellotti, F, Litta, F, Martini, F, Roscio, F, Blanco-Antona, F, Barcenas, F, Schlottmann, F, Herrera-Almario, G, van Ramshorst, G, Gallo, G, Luglio, G, Kampouroglou, G, Papadopoulos, G, Arredondo, G, Calini, G, Formisano, G, Galiffa, G, Palini, G, Colucci, G, Pagano, G, Vanni, G, Pattacini, G, Gravante, G, Lisi, G, Bellanova, G, De Nobili, G, Necchi, G, Sinibaldi, G, Bacchiocchi, G, Bagaglini, G, Maggi, G, Izzo, G, Argenio, G, Brisinda, G, Esposito, G, Frazzetta, G, De Luca, G, Nigri, G, Sica, G, Martin-Martin, G, Ugon, G, Martinez-Mier, G, Machain Vega, G, Nari, G, Nikaj, H, Neri, I, San Roman, I, Fidoshev, I, Martinez, I, Negoi, I, Ortega, I, Vicente Rodriguez, I, Cornejo, I, Mora-Guzman, I, al-Najami, I, Romic, I, Balciscueta, I, Olivier, J, Lammel-Lindemann, J, Dziakova, J, Salinas, J, Jovanovic, J, Reyes, J, Salas, J, Diaz-Elizondo, J, Parreira, J, Bellido, J, Salamea, J, Martin del Olmo, J, Ordonez, J, Junaid, S, Davies, J, Sahnan, K, Bekele, K, Voon, K, Siragusa, L, Petagna, L, Ferrario, L, Giordano, L, Nespoli, L, Pio, L, Moletta, L, Curella, L, Taglietti, L, Bonavina, L, Conti, L, Perez-Sanchez, L, Cabrera Vargas, L, Sanchez-Guillen, L, Tallon-Aguilar, L, Khan, M, Spampinato, M, Viola, M, Malet, M, Angrisani, M, Calussi, M, Catarci, M, Giordano, M, Materazzo, M, Milone, M, Pellicciaro, M, Marino, M, Moreno Villamizar, M, Lolli, M, Bellini, M, Lemma, M, Chiarello, M, Montes-Manrique, M, Rodriguez-Lopez, M, Serradilla-Martin, M, Peter, M, Paniagua-Garcia-Senorans, M, Rutegard, M, Salo, M, Silveri, M, Veroux, M, Nardi, M, Rottoli, M, Tolonen, M, Pedraza Ciro, M, Zuluaga, M, Iacobone, M, Montuori, M, Ali, M, Garcia Dominguez, M, Paola, M, Piccoli, M, Campanelli, M, De Rosa, M, Manigrasso, M, Maruccia, M, Torre, M, Zuolo, M, Pera, M, Weerasekera, M, Prieto, M, Thway, M, Shaat, M, Azfar, M, Shalaby, M, Raza, M, Younis, M, Elhadi, M, Althomali, M, Al Amri, N, Dudi-Venkata, N, Alselaim, N, Smart, N, Trelles, N, Falco, N, Petrucciani, N, Antonacci, N, Cillara, N, Gica, N, Pecorelli, N, Tamini, N, Machairas, N, Feituri, N, Ortega Torrecilla, N, Avila Mercado, O, Alaamer, O, Irkorucu, O, Alsherif, O, Buonomo, O, Valles-Guerra, O, Ioannidis, O, Hernandez Palmas, O, Sanz Guadarrama, O, Bozbiyik, O, Rodrigues, P, Milito, P, Panaccio, P, Dorovinis, P, Prieto, P, Baroffio, P, Marsanic, P, Ajawin, P, Koh, P, Anoldo, P, Major, P, Alharthi, Q, Lui, R, Caruso, R, Brady, R, Rattan, R, Singhal, R, Angelico, R, Isernia, R, Tutino, R, Peltrini, R, Tejos, R, Fajardo, R, Elia, R, Morales-Conde, S, Benli, S, Fuentes, S, de las Casas, S, de Guzman Aragon, S, Vertaldi, S, Awad, S, Gentilli, S, Weckmann Lujan, S, Tayar, S, Althobaiti, S, Di Giovanni, S, Ghedan, S, Perez-Bertolez, S, Chiappetta, S, Delis, S, Scaringi, S, Cetinkunar, S, Kykalos, S, Muhammad Ali, S, Krivan, S, Fung, T, Delko, T, Nicolas Lopez, T, De Campos, T, Calderon Duque, T, Perra, T, Liakakos, T, Daskalakis, T, Koeter, T, Zalla, T, Gonzalez, T, Campagnaro, T, Oumar, T, Grossi, U, Sosa, V, Testa, V, Tomajer, V, Andriola, V, Tonini, V, Celentano, V, Voglino, V, Katta, V, Garcia Orozco, V, Turrado-Rodriguez, V, Visag-Castillo, V, Graham, V, Rachkov, V, Papagni, V, Vigorita, V, Jimenez Carneros, V, Bellato, V, Bechstein, W, Altinel, Y, Balciscueta, Z, Pata F., Di Martino M., Podda M., Di Saverio S., Ielpo B., Pellino G., Julio A., Alshamrani A., Alturkistani A., Alghamdi A., Almalki A., Orengia A., Kuvvetli A., Pisanu A., Smith A., Trevino Figueroa A. M., Nacion A. J., Alhazmi A., Bouhuwaish A., Khalid A., Alsufyani A., Rubio A. V., Bavikatte A., Kumar A., Jamiri A. -R., de San Ildefonso Pereira A., Porcu A., Sartori A., Rocca A., Sretenovic A., Anselmo A., De Luca A., Charalabopoulos A., Tzivanakis A., Bandin A., Najar A., Frontali A., Faisal A., Roldan A. M., Hamid A., Andre A., Minaya-Bravo A., Das A., Bondurri A., Costanzi A., Lucchi A., Mihailescu A., Police A., Zuchini A. M., Romano A., Iossa A., Chessa A., Tromba A., Castaldi A., Brillantino A., Ferronetti A., Giuliani A., Ramos-De la Medina A., Tarasconi A., Picciariello A., Ioannidis A., Leppaniemi A., Rashid A., Mitul A. R., Mehraj A., laharwal A., Iqbal A., Liarakos A., Marinis A., de Andres-Asenjo B., Matias-Garcia B., De Simone B., Creavin B., Stubbs B., Goh B., Jovanovic B., Sensi B., Gazia C., Cerdan C., Diaz C. J. G., Chacon C. P., Yanez C., Faro C. L., Reinke C., Dominguez C., Paranjape C., Thomas C., Fung C. C., De Lucia C., Jennifer C. H. F., Ovalle-Chao C., Guerci C., Kenington C., Gica C., Folliero C., Varela C., Popowich D., Delogu D., Zigiotto D., Vinci D., D'Antonio D., Merlini D. A., Merlini D., Moro-Valdezate D., Keller D., Nicolaescu D. C., Sasia D., Rodas E., Linardoutsos D., Russello D., Najar-Castaneda P. A., Stavrou H. G., Rosso E., Saladino E., Ricciardi E., Smith-Singares E., Baili E., Douka E., Guaitoli E., Francone E., Vaterlini E. M., Pierobon E. S., Morales E., Ros E. P., Benzoni E., Erdas E., Pinotti E., Colas-Ruiz E., Laterza E., Foianini E., Cardamone E., Licardie E., Marino F., Alsofyani F., Qahtani F., Khan F., Maraska F., Saliu F., Madrid F., Rosa F., Luvisetto F., Alconchel F., Pareja-Ciuro F., Neves F., Agresta F., Cordera F., Pardo F., Mendoza-Moreno F., Munoz-Flores F., Silvestri F. M., Tropeano F. P., Pecchini F., Serio F., Colombo F., Di Marzo F., Ferrara F., Lancellotti F., Litta F., Martini F., Roscio F., Blanco-Antona F., Barcenas F. J. Q., Schlottmann F., Herrera-Almario G., van Ramshorst G., Gallo G., Luglio G., Kampouroglou G., Papadopoulos G., Arredondo G., Calini G., Formisano G., Galiffa G., Palini G. M., Colucci G., Pagano G., Vanni G., Pattacini G. C., Gravante G., Lisi G., Bellanova G., De Nobili G., Necchi G. S., Sinibaldi G., Bacchiocchi G., Bagaglini G., Maggi G., Izzo G., Argenio G., Brisinda G., Esposito G., Frazzetta G., De Luca G. M., Nigri G., Sica G., Martin-Martin G., Ugon G. A., Martinez-Mier G., Machain Vega G. M., Nari G., Nikaj H., Neri I., San Roman I. A., Fidoshev I., Martinez I., Negoi I., Ortega I., Vicente Rodriguez I., Cornejo I., Mora-Guzman I., al-Najami I., Romic I., Balciscueta I., Olivier J., Lammel-Lindemann J., Dziakova J., Salinas J., Jovanovic J. P., Reyes J. A. S., Salas J., Diaz-Elizondo J. A., Parreira J. G., Bellido J., Salamea J., Martin del Olmo J. C., Ordonez J. M., Junaid S., Davies J., Sahnan K., Bekele K., Voon K., Siragusa L., Petagna L., Ferrario L., Giordano L., Nespoli L., Pio L., Moletta L., Curella L., Taglietti L., Bonavina L., Conti L., Perez-Sanchez L. E., Cabrera Vargas L. F., Sanchez-Guillen L., Tallon-Aguilar L., Khan M., Spampinato M. G., Viola M., Malet M. V., Angrisani M., Calussi M., Catarci M., Giordano M., Materazzo M., Milone M., Pellicciaro M., Marino M. V., Moreno Villamizar M. D., Lolli M. G., Bellini M. I., Lemma M., Chiarello M. M., Montes-Manrique M., Rodriguez-Lopez M., Serradilla-Martin M., Peter M., Paniagua-Garcia-Senorans M., Rutegard M., Salo M., Silveri M., Veroux M., Nardi M., Rottoli M., Tolonen M., Pedraza Ciro M., Zuluaga M., Iacobone M., Montuori M., Ali M., Garcia Dominguez M., Paola M. M., Piccoli M., Campanelli M., De Rosa M., Manigrasso M., Maruccia M., Torre M., Zuolo M., Pera M., Weerasekera M., Prieto M., Thway M. M., Shaat M., Azfar M., Shalaby M., Raza M. A., Younis M. U., Elhadi M., AlThomali M., Al Amri N., Dudi-Venkata N., Alselaim N., Smart N., Trelles N., Falco N., Petrucciani N., Antonacci N., Cillara N., Gica N., Pecorelli N., Tamini N., Machairas N., Feituri N., Ortega Torrecilla N., Avila Mercado O., AlAamer O., Irkorucu O., Alsherif O., Buonomo O. C., Valles-Guerra O., Ioannidis O., Hernandez Palmas O. I., Sanz Guadarrama O., Bozbiyik O., Rodrigues P., Milito P., Panaccio P., Dorovinis P., Prieto P., Baroffio P., Marsanic P., Ajawin P., Koh P. S., Anoldo P., Major P., Alharthi Q., Lui R., Caruso R., Brady R., Rattan R., Singhal R., Angelico R., Isernia R. M., Tutino R., Peltrini R., Tejos R., Fajardo R., Elia R., Morales-Conde S., Benli S., Fuentes S., de las Casas S. G., de Guzman Aragon S. O., Vertaldi S., Awad S., Gentilli S., Weckmann Lujan S. A., Tayar S., Althobaiti S., Di Giovanni S., Ghedan S., Perez-Bertolez S., Chiappetta S., Delis S., Scaringi S., Cetinkunar S., Kykalos S., Muhammad Ali S., Krivan S., Fung T. L. 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M., Nacion A. J., Alhazmi A., Bouhuwaish A., Khalid A., Alsufyani A., Rubio A. V., Bavikatte A., Kumar A., Jamiri A. -R., de San Ildefonso Pereira A., Porcu A., Sartori A., Rocca A., Sretenovic A., Anselmo A., De Luca A., Charalabopoulos A., Tzivanakis A., Bandin A., Najar A., Frontali A., Faisal A., Roldan A. M., Hamid A., Andre A., Minaya-Bravo A., Das A., Bondurri A., Costanzi A., Lucchi A., Mihailescu A., Police A., Zuchini A. M., Romano A., Iossa A., Chessa A., Tromba A., Castaldi A., Brillantino A., Ferronetti A., Giuliani A., Ramos-De la Medina A., Tarasconi A., Picciariello A., Ioannidis A., Leppaniemi A., Rashid A., Mitul A. R., Mehraj A., laharwal A., Iqbal A., Liarakos A., Marinis A., de Andres-Asenjo B., Matias-Garcia B., De Simone B., Creavin B., Stubbs B., Goh B., Jovanovic B., Sensi B., Gazia C., Cerdan C., Diaz C. J. G., Chacon C. P., Yanez C., Faro C. L., Reinke C., Dominguez C., Paranjape C., Thomas C., Fung C. C., De Lucia C., Jennifer C. H. 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Q., Schlottmann F., Herrera-Almario G., van Ramshorst G., Gallo G., Luglio G., Kampouroglou G., Papadopoulos G., Arredondo G., Calini G., Formisano G., Galiffa G., Palini G. M., Colucci G., Pagano G., Vanni G., Pattacini G. C., Gravante G., Lisi G., Bellanova G., De Nobili G., Necchi G. S., Sinibaldi G., Bacchiocchi G., Bagaglini G., Maggi G., Izzo G., Argenio G., Brisinda G., Esposito G., Frazzetta G., De Luca G. M., Nigri G., Sica G., Martin-Martin G., Ugon G. A., Martinez-Mier G., Machain Vega G. M., Nari G., Nikaj H., Neri I., San Roman I. A., Fidoshev I., Martinez I., Negoi I., Ortega I., Vicente Rodriguez I., Cornejo I., Mora-Guzman I., al-Najami I., Romic I., Balciscueta I., Olivier J., Lammel-Lindemann J., Dziakova J., Salinas J., Jovanovic J. P., Reyes J. A. S., Salas J., Diaz-Elizondo J. A., Parreira J. G., Bellido J., Salamea J., Martin del Olmo J. C., Ordonez J. M., Junaid S., Davies J., Sahnan K., Bekele K., Voon K., Siragusa L., Petagna L., Ferrario L., Giordano L., Nespoli L., Pio L., Moletta L., Curella L., Taglietti L., Bonavina L., Conti L., Perez-Sanchez L. E., Cabrera Vargas L. F., Sanchez-Guillen L., Tallon-Aguilar L., Khan M., Spampinato M. G., Viola M., Malet M. V., Angrisani M., Calussi M., Catarci M., Giordano M., Materazzo M., Milone M., Pellicciaro M., Marino M. V., Moreno Villamizar M. D., Lolli M. G., Bellini M. I., Lemma M., Chiarello M. M., Montes-Manrique M., Rodriguez-Lopez M., Serradilla-Martin M., Peter M., Paniagua-Garcia-Senorans M., Rutegard M., Salo M., Silveri M., Veroux M., Nardi M., Rottoli M., Tolonen M., Pedraza Ciro M., Zuluaga M., Iacobone M., Montuori M., Ali M., Garcia Dominguez M., Paola M. M., Piccoli M., Campanelli M., De Rosa M., Manigrasso M., Maruccia M., Torre M., Zuolo M., Pera M., Weerasekera M., Prieto M., Thway M. M., Shaat M., Azfar M., Shalaby M., Raza M. A., Younis M. U., Elhadi M., AlThomali M., Al Amri N., Dudi-Venkata N., Alselaim N., Smart N., Trelles N., Falco N., Petrucciani N., Antonacci N., Cillara N., Gica N., Pecorelli N., Tamini N., Machairas N., Feituri N., Ortega Torrecilla N., Avila Mercado O., AlAamer O., Irkorucu O., Alsherif O., Buonomo O. C., Valles-Guerra O., Ioannidis O., Hernandez Palmas O. I., Sanz Guadarrama O., Bozbiyik O., Rodrigues P., Milito P., Panaccio P., Dorovinis P., Prieto P., Baroffio P., Marsanic P., Ajawin P., Koh P. S., Anoldo P., Major P., Alharthi Q., Lui R., Caruso R., Brady R., Rattan R., Singhal R., Angelico R., Isernia R. M., Tutino R., Peltrini R., Tejos R., Fajardo R., Elia R., Morales-Conde S., Benli S., Fuentes S., de las Casas S. G., de Guzman Aragon S. O., Vertaldi S., Awad S., Gentilli S., Weckmann Lujan S. A., Tayar S., Althobaiti S., Di Giovanni S., Ghedan S., Perez-Bertolez S., Chiappetta S., Delis S., Scaringi S., Cetinkunar S., Kykalos S., Muhammad Ali S., Krivan S., Fung T. L. D., Delko T., Nicolas Lopez T., De Campos T., Calderon Duque T., Perra T., Liakakos T., Daskalakis T., Koeter T., Zalla T., Gonzalez T. E., Campagnaro T., Oumar T. A., Grossi U., Sosa V., Testa V., Tomajer V., Andriola V., Tonini V., Celentano V., Voglino V., Katta V. R., Garcia Orozco V. H., Turrado-Rodriguez V., Visag-Castillo V., Graham V., Rachkov V., Papagni V., Vigorita V., Jimenez Carneros V., Bellato V., Bechstein W., Altinel Y., and Balciscueta Z.
- Abstract
In the original online version of this article Oreste Claudio Buonomo’s family name was misspelled. The original article was corrected.
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- 2022
5. Phosphorylated CXCR4 expression has a positive prognostic impact in colorectal cancer
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Weixler, B., Renetseder, F., Facile, I., Tosti, N., Cremonesi, E., Tampakis, A., Delko, T., Eppenberger-Castori, S., Tzankov, A., Iezzi, G., Kettelhack, C., Soysal, S. D., von Holzen, U., Spagnoli, G. C., Terracciano, L., Tornillo, L., Droeser, Raoul A., and Däster, S.
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- 2017
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6. Endoscopic surveillance after bariatric surgery: Results from a large, single-institution cohort
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Lazaridis, I, primary, Kraljevic, M, additional, Thomas, K, additional, Gätzi, D, additional, Stöcklin, P, additional, Zingg, U, additional, and Delko, T, additional
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- 2022
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7. Influence of Additional Resection of the Gastric Fundus on Excessive Weight Loss in Laparoscopic Very Very Long Limb Roux-en-Y Gastric Bypass
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Delko, T., Köstler, T., Peev, M., Oertli, D., and Zingg, U.
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- 2013
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8. Roux-en-Y gastric bypass with a long compared to a short biliopancreatic limb leads to better weight loss and glycemic control in obese mice
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Schneider, R, primary, Kraljević, M, additional, Peterson, C J, additional, Lazaridis, I, additional, Rohm, T V, additional, Bosch, A J T, additional, Low, A J Y, additional, Vonaesch, P, additional, Peterli, R, additional, Delko, T, additional, and Cavelti-Weder, C, additional
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- 2021
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9. The Impact of the COVID-19 Pandemic on Bariatric Surgery: Results from a Worldwide Survey
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Lazaridis, I.I. Kraljević, M. Schneider, R. Klasen, J.M. Schizas, D. Peterli, R. Kow, L. Delko, T. Noel, P. Singhal, R. Girodet, M. Soprani, A. Brehant, O. Moszkowicz, D. Coueffe, X. Lanne, J.S. Rosenblum, I. Moldovanu, R. Pflieger, H. Kuperas, C. Martinez Duartez, P. Luyer, M.D.P. Arnalsteen, L. Hazebroek, E.J. Sykora, M. Kennedy, C. Hauswirth, F. Tchanderli-Braham, R. Le Page, S. Boerma, E.-J.G. Chousleb, E. Langenhoff, B. ElFawal, M.H. Paolino, L. Martini, F. Johanet, H. Barthes, T. Halabi, M. Del Prete, M. Fiolo, F.E. Blanchard, C. Bashir, A. Hagen, M. Techagumpuch, A. Dan, S. Catheline, J.-M. Georgeac, C. Lefter, L.P. Lechaux, D. Widmer, J. Kaijser, M.A. Orlowski, M. François, P. Rogers, A.M. Nitu, V. Servajean, S. Fishman, M. Ignat, D.M. Molasoko, J.M. Takkenberg, M. Amal, E. Charara, M. Parmar, C. Brévart, C. Warberg, E.A. Marx, L. Vix, M. for the Collaborators
- Abstract
Background: The ongoing “coronavirus disease 19” (COVID-19) pandemic has had a strong effect on the delivery of surgical care worldwide. Elective surgeries have been canceled or delayed in order to reallocate resources to the treatment of COVID-19 patients. Currently, the impact of the COVID-19 pandemic on bariatric and metabolic surgical practice remains unclear. Methods: An internet-based online survey was performed among bariatric surgeons worldwide. The survey was sent to bariatric surgeons via the International Bariatric Club Facebook group and by electronic mail via the International Federation for the Surgery of Obesity and metabolic disorders (IFSO) secretariat to members of the associated national IFSO societies. Results: One hundred sixty-nine (n = 169) bariatric surgeons participated in the survey. The majority of the respondents postponed preoperative upper gastrointestinal tract endoscopies, appointments in the outpatient clinic and bariatric operations. Most surgeons performed video calls for follow-up appointments instead of meeting the patients in the outpatient clinics. Laparoscopy was still the preferred treatment for surgical emergencies, but a trend towards conservative treatment of acute appendicitis and acute cholecystitis was shown. Rapid preoperative COVID-19 testing availability was poor; therefore, routine screening of emergency bariatric cases was not widely provided. A wide variance occurred regarding precautions and personal protection equipment among the participants. Conclusion: The COVID-19 pandemic showed a strong impact on bariatric surgical practice regarding surgical and outpatient planning as well as personnel management. Coordinated effort from the national bariatric societies should focus on strict implementation of the current recommendations regarding precaution measures and personal protection equipment. Further studies should evaluate how this impact will evolve in the near future. © 2020, Springer Science+Business Media, LLC, part of Springer Nature.
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- 2020
10. Intestinale Mikroperfusion während kolorektaler Resektionen. Erste Resultate von 34 Patienten
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Hoffmann, H, primary, Delko, T, additional, Nebiker, C, additional, Kraljevic, M, additional, Schäfer, J, additional, and Kettelhack, C, additional
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- 2015
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11. Obstruierendes Blutkoagel in der Jejunojejunostomie nach laparoskopischem Magenbypass
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Delko, T, Grossen, E, Jung, M, Köstler, T, and Schöb, O
- Subjects
ddc: 610 ,610 Medical sciences ,Medicine - Abstract
Einleitung: Die Staplernahtreihenblutung nach laparoskopischem Magenbypass ist eine bekannte Frühkomplikation. In unserer Klinik wurden seit dem Jahr 2000 über 250 distale Magenbypass Operationen sowie über 50 Redo Operationen laparoskopisch durchgeführt. Klammernahtblutungen traten[for full text, please go to the a.m. URL], 127. Kongress der Deutschen Gesellschaft für Chirurgie
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- 2010
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12. Laparoskopische Konversion des Magenbypass in eine biliopankreatischen Diversion bei Gewichtsrebound: präliminäre Resultate
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Jung, M, Köstler, T, Delko, T, and Schöb, O
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ddc: 610 ,610 Medical sciences ,Medicine - Abstract
Einleitung: Gewichtszunahme nach Magenbypassoperation bei Adipositas per magna tritt in der Literatur in bis zu 20–35% auf. Die biliopankreatische Diversion (BPD) stellt eine mögliche Redo-Operation dar. Wir berichten über die Technik und die Resultate der laparoskopischen Konversion[for full text, please go to the a.m. URL], 127. Kongress der Deutschen Gesellschaft für Chirurgie
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- 2010
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13. Sustained attention and planning deficits but intact attentional set-shifting in neuroleptic-naïve first-episode schizophrenia patients
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Hilti, C C, Delko, T, Orosz, A T, Thomann, K, Ludewig, S, Geyer, M A, Vollenweider, F X, Feldon, J, Cattapan-Ludewig, K, and University of Zurich
- Subjects
3206 Neuropsychology and Physiological Psychology ,2738 Psychiatry and Mental Health ,10054 Clinic for Psychiatry, Psychotherapy, and Psychosomatics ,610 Medicine & health ,2803 Biological Psychiatry - Published
- 2010
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14. Internal hernia in late pregnancy after laparoscopic Roux-en-Y gastric bypass
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Gruetter, F., primary, Kraljevic, M., additional, Nebiker, C. A., additional, and Delko, T., additional
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- 2014
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15. Two similar cases of internal hernia after laparoscopic Roux-en-Y gastric bypass surgery
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Daster, S., primary, Droeser, R. A., additional, Delko, T., additional, and Oertli, D., additional
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- 2013
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16. Acute thyroid swelling and elevated C reactive protein
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Nebiker, C. A., primary, Delko, T., additional, Zulewski, H., additional, and Oertli, D., additional
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- 2013
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17. Influence of Additional Resection of the Gastric Fundus on Excessive Weight Loss in Laparoscopic Very Very Long Limb Roux-en-Y Gastric Bypass
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Delko, T., primary, Köstler, T., additional, Peev, M., additional, Oertli, D., additional, and Zingg, U., additional
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- 2012
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18. Two years later: Is the SARS-CoV-2 pandemic still having an impact on emergency surgery? An international cross-sectional survey among WSES members
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Reichert, Martin, Sartelli, Massimo, Weigand, Markus A, Hecker, Matthias, Oppelt, Philip U, Noll, Julia, Askevold, Ingolf H, Liese, Juliane, Padberg, Winfried, Coccolini, Federico, Catena, Fausto, Hecker, Andreas, Adam Peckham-Cooper, Adrian Camacho-Ortiz, Aikaterini T. Mastoraki, Aitor Landaluce-Olavarria, Ajay Kumar Pal, Akira Kuriyama, Alain Chichom-Mefire, Alberto Porcu, Aleix Martínez-Pérez, Aleksandar R. Karamarkovic, Aleksei V. Osipov, Alessandro Coppola, Alessandro Cucchetti, Alessandro Spolini, Alessio Giordano, Alexander Reinisch-Liese, Alfie J. Kavalakat, Alin Vasilescu, Amin Alamin, Amit Gupta, Ana Maria Dascalu, Ana-Maria Musina, Anargyros Bakopoulos, Andee Dzulkarnaen Zakaria, Andras Vereczkei, Andrea Balla, Andrea Bottari, Andreas Baumann, Andreas Fette, Andrey Litvin, Aniella Katharina Reichert, Anna Guariniello, Anna Paspala, Anne-Sophie Schneck, Antonio Brillantino, Antonio Pesce, Arda Isik, Ari Kalevi Leppäniemi, Aristeidis Papadopoulos, Aristotelis Kechagias, Ashraf Yehya Abdalla Mohamed, Ashrarur Rahman Mitul, Athanasios Marinis, Athanasios Syllaios, Baris Mantoglu, Belinda De Simone, Benjamin Stefan Weiss, Bernd Pösentrup, Biagio Picardi, Biagio Zampogna, Boris Eugeniev Sakakushev, Boyko Chavdarov Atanasov, Bruno Nardo, Bulent Calik, Camilla Cremonini, Carlos A. Ordoñez, Charalampos Seretis, Chiara Cascone, Christos Chouliaras, Cino Bendinelli, Claudia Lopes, Claudio Guerci, Clemens Weber, Constantinos Nastos, Cristian Mesina, Damiano Caputo, Damien Massalou, Davide Cavaliere, Deborah A. McNamara, Demetrios Demetriades, Desirè Pantalone, Diego Coletta, Diego Sasia, Diego Visconti, Dieter G. Weber, Diletta Corallino, Dimitrios Chatzipetris, Dimitrios K. Manatakis, Dimitrios Ntourakis, Dimitrios Papaconstantinou, Dimitrios Schizas, Dimosthenis Chrysikos, Dmitry Mikhailovich Adamovich, Doaa Elkafrawy, Dragos Seban, Edgar Fernando Hernandez García, Edoardo Baldini, Edoardo Picetti, Edward C. T. H. Tan, Efstratia Baili, Eftychios Lostoridis, Elena Adelina Toma, Elif Colak, Elisabetta Cerutti, Elmin Steyn, Elmuiz A. Hsabo, Emmanouil Ioannis Kapetanakis, Emmanouil Kaouras, Emmanuel Schneck, Emrah Akin, Emre Gonullu, Enes çelik, Enrico Cicuttin, Enrico Pinotti, Erik Johnsson, Ernest E. Moore, Ervis Agastra, Evgeni Nikolaev Dimitrov, Ewen A. Griffiths, Fabrizio D’Acapito, Federica Saraceno, Felipe Alconchel, Felix Alexander Zeppernick, Fernando Machado Rodríguez, Fikri Abu-Zidan, Francesca Pecchini, Francesco Favi, Francesco Ferrara, Francesco Fleres, Francesco Pata, Francesco Pietro Maria Roscio, Francesk Mulita, Frank J. M. F. Dor, Fredrik Linder, Gabriel Dimofte, Gabriel Rodrigues, Gabriela Nita, Gabriele Sganga, Gennaro Martines, Gennaro Mazzarella, Gennaro Perrone, George Velmahos, Georgios D. Lianos, Gia Tomadze, Gian Luca Baiocchi, Giancarlo D’Ambrosio, Gianluca Pellino, Gianmaria Casoni Pattacini, Giorgio Giraudo, Giorgio Lisi, Giovanni Domenico Tebala, Giovanni Pirozzolo, Giulia Montori, Giulio Argenio, Giuseppe Brisinda, Giuseppe Currò, Giuseppe Giuliani, Giuseppe Palomba, Giuseppe Roscitano, Gökhan Avşar, Goran Augustin, Guglielmo Clarizia, Gustavo M. Machain Vega, Gustavo P. Fraga, Harsheet Sethi, Hazim Abdulnassir Eltyeb, Helmut A. Segovia Lohse, Herald René Segovia Lohse, Hüseyin Bayhan, Hytham K. S. Hamid, Igor A. Kryvoruchko, Immacolata Iannone, Imtiaz Wani, Ioannis I. Lazaridis, Ioannis Katsaros, Ioannis Nikolopoulos, Ionut Negoi, Isabella Reccia, Isidoro Di Carlo, Iyiade Olatunde Olaoye, Jacek Czepiel, Jae Il Kim, Jeremy Meyer, Jesus Manuel Saenz Terrazas, Joel Noutakdie Tochie, Joseph M. Galante, Justin Davies, Kapil Sugand, Kebebe Bekele Gonfa, Kemal Rasa, Kenneth Y. Y. Kok, Konstantinos G. Apostolou, Konstantinos Lasithiotakis, Konstantinos Tsekouras, Kumar Angamuthu, Lali Akhmeteli, Larysa Sydorchuk, Laura Fortuna, Leandro Siragusa, Leonardo Pagani, Leonardo Solaini, Lisa A. Miller, Lovenish Bains, Luca Ansaloni, Luca Ferrario, Luigi Bonavina, Luigi Conti, Luis Antonio Buonomo, Luis Tallon-Aguilar, Lukas Tomczyk, Lukas Werner Widmer, Maciej Walędziak, Mahir Gachabayov, Maloni M. Bulanauca, Manu L. N. G. Malbrain, Marc Maegele, Marco Catarci, Marco Ceresoli, Maria Chiara Ranucci, Maria Ioanna Antonopoulou, Maria Papadoliopoulou, Maria Rosaria Valenti, Maria Sotiropoulou, Mario D’Oria, Mario Serradilla Martín, Markus Hirschburger, Massimiliano Veroux, Massimo Fantoni, Matteo Nardi, Matti Tolonen, Mauro Montuori, Mauro Podda, Maximilian Scheiterle, Maximos Frountzas, Mehmet Sarıkaya, Mehmet Yildirim, Michael Bender, Michail Vailas, Michel Teuben, Michela Campanelli, Michele Ammendola, Michele Malerba, Michele Pisano, Mihaela Pertea, Mihail Slavchev, Mika Ukkonen, Miklosh Bala, Mircea Chirica, Mirko Barone, Mohamed Maher Shaat, Mohammed Jibreel Suliman Mohammed, Mona Awad Akasha Abuelgasim, Monika Gureh, Mouaqit Ouadii, Mujdat Balkan, Mumin Mohamed, Musluh Hakseven, Natalia Velenciuc, Nicola Cillara, Nicola de’Angelis, Nicolò Tamini, Nikolaos J. Zavras, Nikolaos Machairas, Nikolaos Michalopoulos, Nikolaos N. Koliakos, Nikolaos Pararas, Noel E. Donlon, Noushif Medappil, Offir Ben-Ishay, Olmi Stefano, Omar Islam, Ömer Tammo, Orestis Ioannidis, Oscar Aparicio, Oussama Baraket, Pankaj Kumar, Pasquale Cianci, Per Örtenwall, Petar Angelov Uchikov, Philip de Reuver, Philip F. Stahel, Philip S. Barie, Micaela Piccoli, Piotr Major, Pradeep H. Navsaria, Prakash Kumar Sasmal, Raul Coimbra, Razrim Rahim, Recayi Çapoğlu, Renol M. Koshy, Ricardo Alessandro Teixeira Gonsaga, Riccardo Pertile, Rifat Ramadan Mussa Mohamed, Rıza Deryol, Robert G. Sawyer, Roberta Angelico, Roberta Ragozzino, Roberto Bini, Roberto Cammarata, Rosa Scaramuzzo, Rossella Gioco, Ruslan Sydorchuk, Salma Ahmed, Salomone Di Saverio, Sameh Hany Emile, Samir Delibegovic, Sanjay Marwah, Savvas Symeonidis, Scott G. Thomas, Sebahattin Demir, Selmy S. Awad, Semra Demirli Atici, Serge Chooklin, Serhat Meric, Sevcan Sarıkaya, Sharfuddin Chowdhury, Shaza Faycal Mirghani, Sherry M. Wren, Simone Gargarella, Simone Rossi Del Monte, Sofia Esposito, Sofia Xenaki, Soliman Fayez Ghedan Mohamed, Solomon Gurmu Beka, Sorinel Lunca, Spiros G. Delis, Spyridon Dritsas, Stefan Morarasu, Stefano Magnone, Stefano Rossi, Stefanos Bitsianis, Stylianos Kykalos, Suman Baral, Sumita A. Jain, Syed Muhammad Ali, Tadeja Pintar, Tania Triantafyllou, Tarik Delko, Teresa Perra, Theodoros A. Sidiropoulos, Thomas M. Scalea, Tim Oliver Vilz, Timothy Craig Hardcastle, Tongporn Wannatoop, Torsten Herzog, Tushar Subhadarshan Mishra, Ugo Boggi, Valentin Calu, Valentina Tomajer, Vanni Agnoletti, Varut Lohsiriwat, Victor Kong, Virginia Durán Muñoz-Cruzado, Vishal G. Shelat, Vladimir Khokha, Wagih Mommtaz Ghannam, Walter L. Biffl, Wietse Zuidema, Yasin Kara, Yoshiro Kobe, Zaza Demetrashvili, Ziad A. Memish, Zoilo Madrazo, Zsolt J. Balogh, Zulfu Bayhan, Surgery, AMS - Musculoskeletal Health, Other Research, APH - Quality of Care, Reichert, Martin, Sartelli, Massimo, Weigand, Markus A, Hecker, Matthia, Oppelt, Philip U, Noll, Julia, Askevold, Ingolf H, Liese, Juliane, Padberg, Winfried, Coccolini, Federico, Catena, Fausto, Hecker, Andrea, Adam Peckham-Cooper, Adrian Camacho-Ortiz, Aikaterini T. Mastoraki, Aitor Landaluce-Olavarria, Ajay Kumar Pal, Akira Kuriyama, Alain Chichom-Mefire, Alberto Porcu, Aleix Martínez-Pérez, Aleksandar R. Karamarkovic, Aleksei V. Osipov, Alessandro Coppola, Alessandro Cucchetti, Alessandro Spolini, Alessio Giordano, Alexander Reinisch-Liese, Alfie J. Kavalakat, Alin Vasilescu, Amin Alamin, Amit Gupta, Ana Maria Dascalu, Ana-Maria Musina, Anargyros Bakopoulos, Andee Dzulkarnaen Zakaria, Andras Vereczkei, Andrea Balla, Andrea Bottari, Andreas Baumann, Andreas Fette, Andrey Litvin, Aniella Katharina Reichert, Anna Guariniello, Anna Paspala, Anne-Sophie Schneck, Antonio Brillantino, Antonio Pesce, Arda Isik, Ari Kalevi Leppäniemi, Aristeidis Papadopoulos, Aristotelis Kechagias, Ashraf Yehya Abdalla Mohamed, Ashrarur Rahman Mitul, Athanasios Marinis, Athanasios Syllaios, Baris Mantoglu, Belinda De Simone, Benjamin Stefan Weiss, Bernd Pösentrup, Biagio Picardi, Biagio Zampogna, Boris Eugeniev Sakakushev, Boyko Chavdarov Atanasov, Bruno Nardo, Bulent Calik, Camilla Cremonini, Carlos A. Ordoñez, Charalampos Seretis, Chiara Cascone, Christos Chouliaras, Cino Bendinelli, Claudia Lopes, Claudio Guerci, Clemens Weber, Constantinos Nastos, Cristian Mesina, Damiano Caputo, Damien Massalou, Davide Cavaliere, Deborah A. McNamara, Demetrios Demetriades, Desirè Pantalone, Diego Coletta, Diego Sasia, Diego Visconti, Dieter G. Weber, Diletta Corallino, Dimitrios Chatzipetris, Dimitrios K. Manatakis, Dimitrios Ntourakis, Dimitrios Papaconstantinou, Dimitrios Schizas, Dimosthenis Chrysikos, Dmitry Mikhailovich Adamovich, Doaa Elkafrawy, Dragos Seban, Edgar Fernando Hernandez García, Edoardo Baldini, Edoardo Picetti, Edward C. T. H. Tan, Efstratia Baili, Eftychios Lostoridis, Elena Adelina Toma, Elif Colak, Elisabetta Cerutti, Elmin Steyn, Elmuiz A. Hsabo, Emmanouil Ioannis Kapetanakis, Emmanouil Kaouras, Emmanuel Schneck, Emrah Akin, Emre Gonullu, Enes çelik, Enrico Cicuttin, Enrico Pinotti, Erik Johnsson, Ernest E. Moore, Ervis Agastra, Evgeni Nikolaev Dimitrov, Ewen A. Griffiths, Fabrizio D’Acapito, Federica Saraceno, Felipe Alconchel, Felix Alexander Zeppernick, Fernando Machado Rodríguez, Fikri Abu-Zidan, Francesca Pecchini, Francesco Favi, Francesco Ferrara, Francesco Fleres, Francesco Pata, Francesco Pietro Maria Roscio, Francesk Mulita, Frank J. M. F. Dor, Fredrik Linder, Gabriel Dimofte, Gabriel Rodrigues, Gabriela Nita, Gabriele Sganga, Gennaro Martines, Gennaro Mazzarella, Gennaro Perrone, George Velmahos, Georgios D. Lianos, Gia Tomadze, Gian Luca Baiocchi, Giancarlo D’Ambrosio, Gianluca Pellino, Gianmaria Casoni Pattacini, Giorgio Giraudo, Giorgio Lisi, Giovanni Domenico Tebala, Giovanni Pirozzolo, Giulia Montori, Giulio Argenio, Giuseppe Brisinda, Giuseppe Currò, Giuseppe Giuliani, Giuseppe Palomba, Giuseppe Roscitano, Gökhan Avşar, Goran Augustin, Guglielmo Clarizia, Gustavo M. Machain Vega, Gustavo P. Fraga, Harsheet Sethi, Hazim Abdulnassir Eltyeb, Helmut A. Segovia Lohse, Herald René Segovia Lohse, Hüseyin Bayhan, Hytham K. S. Hamid, Igor A. Kryvoruchko, Immacolata Iannone, Imtiaz Wani, Ioannis I. Lazaridis, Ioannis Katsaros, Ioannis Nikolopoulos, Ionut Negoi, Isabella Reccia, Isidoro Di Carlo, Iyiade Olatunde Olaoye, Jacek Czepiel, Jae Il Kim, Jeremy Meyer, Jesus Manuel Saenz Terrazas, Joel Noutakdie Tochie, Joseph M. Galante, Justin Davies, Kapil Sugand, Kebebe Bekele Gonfa, Kemal Rasa, Kenneth Y. Y. Kok, Konstantinos G. Apostolou, Konstantinos Lasithiotakis, Konstantinos Tsekouras, Kumar Angamuthu, Lali Akhmeteli, Larysa Sydorchuk, Laura Fortuna, Leandro Siragusa, Leonardo Pagani, Leonardo Solaini, Lisa A. Miller, Lovenish Bains, Luca Ansaloni, Luca Ferrario, Luigi Bonavina, Luigi Conti, Luis Antonio Buonomo, Luis Tallon-Aguilar, Lukas Tomczyk, Lukas Werner Widmer, Maciej Walędziak, Mahir Gachabayov, Maloni M. Bulanauca, Manu L. N. G. Malbrain, Marc Maegele, Marco Catarci, Marco Ceresoli, Maria Chiara Ranucci, Maria Ioanna Antonopoulou, Maria Papadoliopoulou, Maria Rosaria Valenti, Maria Sotiropoulou, Mario D’Oria, Mario Serradilla Martín, Markus Hirschburger, Massimiliano Veroux, Massimo Fantoni, Matteo Nardi, Matti Tolonen, Mauro Montuori, Mauro Podda, Maximilian Scheiterle, Maximos Frountzas, Mehmet Sarıkaya, Mehmet Yildirim, Michael Bender, Michail Vailas, Michel Teuben, Michela Campanelli, Michele Ammendola, Michele Malerba, Michele Pisano, Mihaela Pertea, Mihail Slavchev, Mika Ukkonen, Miklosh Bala, Mircea Chirica, Mirko Barone, Mohamed Maher Shaat, Mohammed Jibreel Suliman Mohammed, Mona Awad Akasha Abuelgasim, Monika Gureh, Mouaqit Ouadii, Mujdat Balkan, Mumin Mohamed, Musluh Hakseven, Natalia Velenciuc, Nicola Cillara, Nicola de’Angelis, Nicolò Tamini, Nikolaos J. Zavras, Nikolaos Machairas, Nikolaos Michalopoulos, Nikolaos N. Koliakos, Nikolaos Pararas, Noel E. Donlon, Noushif Medappil, Offir Ben-Ishay, Olmi Stefano, Omar Islam, Ömer Tammo, Orestis Ioannidis, Oscar Aparicio, Oussama Baraket, Pankaj Kumar, Pasquale Cianci, Per Örtenwall, Petar Angelov Uchikov, Philip de Reuver, Philip F. Stahel, Philip S. Barie, Micaela Piccoli, Piotr Major, Pradeep H. Navsaria, Prakash Kumar Sasmal, Raul Coimbra, Razrim Rahim, Recayi Çapoğlu, Renol M. Koshy, Ricardo Alessandro Teixeira Gonsaga, Riccardo Pertile, Rifat Ramadan Mussa Mohamed, Rıza Deryol, Robert G. Sawyer, Roberta Angelico, Roberta Ragozzino, Roberto Bini, Roberto Cammarata, Rosa Scaramuzzo, Rossella Gioco, Ruslan Sydorchuk, Salma Ahmed, Salomone Di Saverio, Sameh Hany Emile, Samir Delibegovic, Sanjay Marwah, Savvas Symeonidis, Scott G. Thomas, Sebahattin Demir, Selmy S. Awad, Semra Demirli Atici, Serge Chooklin, Serhat Meric, Sevcan Sarıkaya, Sharfuddin Chowdhury, Shaza Faycal Mirghani, Sherry M. Wren, Simone Gargarella, Simone Rossi Del Monte, Sofia Esposito, Sofia Xenaki, Soliman Fayez Ghedan Mohamed, Solomon Gurmu Beka, Sorinel Lunca, Spiros G. Delis, Spyridon Dritsas, Stefan Morarasu, Stefano Magnone, Stefano Rossi, Stefanos Bitsianis, Stylianos Kykalos, Suman Baral, Sumita A. Jain, Syed Muhammad Ali, Tadeja Pintar, Tania Triantafyllou, Tarik Delko, Teresa Perra, Theodoros A. Sidiropoulos, Thomas M. Scalea, Tim Oliver Vilz, Timothy Craig Hardcastle, Tongporn Wannatoop, Torsten Herzog, Tushar Subhadarshan Mishra, Ugo Boggi, Valentin Calu, Valentina Tomajer, Vanni Agnoletti, Varut Lohsiriwat, Victor Kong, Virginia Durán Muñoz-Cruzado, Vishal G. Shelat, Vladimir Khokha, Wagih Mommtaz Ghannam, Walter L. Biffl, Wietse Zuidema, Yasin Kara, Yoshiro Kobe, Zaza Demetrashvili, Ziad A. Memish, Zoilo Madrazo, Zsolt J. Balogh, Zulfu Bayhan, Reichert, M, Sartelli, M, Weigand, M, Hecker, M, Oppelt, P, Noll, J, Askevold, I, Liese, J, Padberg, W, Coccolini, F, Catena, F, Hecker, A, Peckham-Cooper, A, Camacho-Ortiz, A, Mastoraki, A, Landaluce-Olavarria, A, Pal, A, Kuriyama, A, Chichom-Mefire, A, Porcu, A, Martinez-Perez, A, Karamarkovic, A, Osipov, A, Coppola, A, Cucchetti, A, Spolini, A, Giordano, A, Reinisch-Liese, A, Kavalakat, A, Vasilescu, A, Alamin, A, Gupta, A, Dascalu, A, Musina, A, Bakopoulos, A, Zakaria, A, Vereczkei, A, Balla, A, Bottari, A, Baumann, A, Fette, A, Litvin, A, Reichert, A, Guariniello, A, Paspala, A, Schneck, A, Brillantino, A, Pesce, A, Isik, A, Leppaniemi, A, Papadopoulos, A, Kechagias, A, Mohamed, A, Mitul, A, Marinis, A, Syllaios, A, Mantoglu, B, De Simone, B, Weiss, B, Posentrup, B, Picardi, B, Zampogna, B, Sakakushev, B, Atanasov, B, Nardo, B, Calik, B, Cremonini, C, Ordonez, C, Seretis, C, Cascone, C, Chouliaras, C, Bendinelli, C, Lopes, C, Guerci, C, Weber, C, Nastos, C, Mesina, C, Caputo, D, Massalou, D, Cavaliere, D, Mcnamara, D, Demetriades, D, Pantalone, D, Coletta, D, Sasia, D, Visconti, D, Weber, D, Corallino, D, Chatzipetris, D, Manatakis, D, Ntourakis, D, Papaconstantinou, D, Schizas, D, Chrysikos, D, Adamovich, D, Elkafrawy, D, Seban, D, Garcia, E, Baldini, E, Picetti, E, Tan, E, Baili, E, Lostoridis, E, Toma, E, Colak, E, Cerutti, E, Steyn, E, Hsabo, E, Kapetanakis, E, Kaouras, E, Schneck, E, Akin, E, Gonullu, E, Celik, E, Cicuttin, E, Pinotti, E, Johnsson, E, Moore, E, Agastra, E, Dimitrov, E, Griffiths, E, D'Acapito, F, Saraceno, F, Alconchel, F, Zeppernick, F, Rodriguez, F, Abu-Zidan, F, Pecchini, F, Favi, F, Ferrara, F, Fleres, F, Pata, F, Roscio, F, Mulita, F, Dor, F, Linder, F, Dimofte, G, Rodrigues, G, Nita, G, Sganga, G, Martines, G, Mazzarella, G, Perrone, G, Velmahos, G, Lianos, G, Tomadze, G, Baiocchi, G, D'Ambrosio, G, Pellino, G, Pattacini, G, Giraudo, G, Lisi, G, Tebala, G, Pirozzolo, G, Montori, G, Argenio, G, Brisinda, G, Curro, G, Giuliani, G, Palomba, G, Roscitano, G, Avsar, G, Augustin, G, Clarizia, G, Vega, G, Fraga, G, Sethi, H, Eltyeb, H, Lohse, H, Bayhan, H, Hamid, H, Kryvoruchko, I, Iannone, I, Wani, I, Lazaridis, I, Katsaros, I, Nikolopoulos, I, Negoi, I, Reccia, I, Di Carlo, I, Olaoye, I, Czepiel, J, Kim, J, Meyer, J, Terrazas, J, Tochie, J, Galante, J, Davies, J, Sugand, K, Gonfa, K, Rasa, K, Kok, K, Apostolou, K, Lasithiotakis, K, Tsekouras, K, Angamuthu, K, Akhmeteli, L, Sydorchuk, L, Fortuna, L, Siragusa, L, Pagani, L, Solaini, L, Miller, L, Bains, L, Ansaloni, L, Ferrario, L, Bonavina, L, Conti, L, Buonomo, L, Tallon-Aguilar, L, Tomczyk, L, Widmer, L, Waledziak, M, Gachabayov, M, Bulanauca, M, Malbrain, M, Maegele, M, Catarci, M, Ceresoli, M, Ranucci, M, Antonopoulou, M, Papadoliopoulou, M, Valenti, M, Sotiropoulou, M, D'Oria, M, Martin, M, Hirschburger, M, Veroux, M, Fantoni, M, Nardi, M, Tolonen, M, Montuori, M, Podda, M, Scheiterle, M, Frountzas, M, Sarikaya, M, Yildirim, M, Bender, M, Vailas, M, Teuben, M, Campanelli, M, Ammendola, M, Malerba, M, Pisano, M, Pertea, M, Slavchev, M, Ukkonen, M, Bala, M, Chirica, M, Barone, M, Shaat, M, Mohammed, M, Abuelgasim, M, Gureh, M, Ouadii, M, Balkan, M, Mohamed, M, Hakseven, M, Velenciuc, N, Cillara, N, De'Angelis, N, Tamini, N, Zavras, N, Machairas, N, Michalopoulos, N, Koliakos, N, Pararas, N, Donlon, N, Medappil, N, Ben-Ishay, O, Stefano, O, Islam, O, Tammo, O, Ioannidis, O, Aparicio, O, Baraket, O, Kumar, P, Cianci, P, Ortenwall, P, Uchikov, P, de Reuver, P, Stahel, P, Barie, P, Piccoli, M, Major, P, Navsaria, P, Sasmal, P, Coimbra, R, Rahim, R, Capoglu, R, Koshy, R, Gonsaga, R, Pertile, R, Mohamed, R, Deryol, R, Sawyer, R, Angelico, R, Ragozzino, R, Bini, R, Cammarata, R, Scaramuzzo, R, Gioco, R, Sydorchuk, R, Ahmed, S, Di Saverio, S, Emile, S, Delibegovic, S, Marwah, S, Symeonidis, S, Thomas, S, Demir, S, Awad, S, Atici, S, Chooklin, S, Meric, S, Sarikaya, S, Chowdhury, S, Mirghani, S, Wren, S, Gargarella, S, Del Monte, S, Esposito, S, Xenaki, S, Mohamed, S, Beka, S, Lunca, S, Delis, S, Dritsas, S, Morarasu, S, Magnone, S, Rossi, S, Bitsianis, S, Kykalos, S, Baral, S, Jain, S, Ali, S, Pintar, T, Triantafyllou, T, Delko, T, Perra, T, Sidiropoulos, T, Scalea, T, Vilz, T, Hardcastle, T, Wannatoop, T, Herzog, T, Mishra, T, Boggi, U, Calu, V, Tomajer, V, Agnoletti, V, Lohsiriwat, V, Kong, V, Munoz-Cruzado, V, Shelat, V, Khokha, V, Ghannam, W, Biffl, W, Zuidema, W, Kara, Y, Kobe, Y, Demetrashvili, Z, Memish, Z, Madrazo, Z, Balogh, Z, and Bayhan, Z
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Cross-Sectional Studie ,ddc:610 ,Capacity ,Pandemic ,SARS-CoV-2 ,COVID-19 ,WSES ,Time to intervention ,Appendicitis ,Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10] ,Cross-Sectional Studies ,Emergency ,Quarantine ,Emergency Medicine ,Emergency surgery ,Humans ,Surgery ,Appendiciti ,COVID-19, SARS-CoV-2, Pandemic, Emergency surgery, Emergency, Appendicitis, WSES, Time to intervention, Capacity, Quarantine ,Pandemics ,Diverticulitis ,Human - Abstract
Background The SARS-CoV-2 pandemic is still ongoing and a major challenge for health care services worldwide. In the first WSES COVID-19 emergency surgery survey, a strong negative impact on emergency surgery (ES) had been described already early in the pandemic situation. However, the knowledge is limited about current effects of the pandemic on patient flow through emergency rooms, daily routine and decision making in ES as well as their changes over time during the last two pandemic years. This second WSES COVID-19 emergency surgery survey investigates the impact of the SARS-CoV-2 pandemic on ES during the course of the pandemic. Methods A web survey had been distributed to medical specialists in ES during a four-week period from January 2022, investigating the impact of the pandemic on patients and septic diseases both requiring ES, structural problems due to the pandemic and time-to-intervention in ES routine. Results 367 collaborators from 59 countries responded to the survey. The majority indicated that the pandemic still significantly impacts on treatment and outcome of surgical emergency patients (83.1% and 78.5%, respectively). As reasons, the collaborators reported decreased case load in ES (44.7%), but patients presenting with more prolonged and severe diseases, especially concerning perforated appendicitis (62.1%) and diverticulitis (57.5%). Otherwise, approximately 50% of the participants still observe a delay in time-to-intervention in ES compared with the situation before the pandemic. Relevant causes leading to enlarged time-to-intervention in ES during the pandemic are persistent problems with in-hospital logistics, lacks in medical staff as well as operating room and intensive care capacities during the pandemic. This leads not only to the need for triage or transferring of ES patients to other hospitals, reported by 64.0% and 48.8% of the collaborators, respectively, but also to paradigm shifts in treatment modalities to non-operative approaches reported by 67.3% of the participants, especially in uncomplicated appendicitis, cholecystitis and multiple-recurrent diverticulitis. Conclusions The SARS-CoV-2 pandemic still significantly impacts on care and outcome of patients in ES. Well-known problems with in-hospital logistics are not sufficiently resolved by now; however, medical staff shortages and reduced capacities have been dramatically aggravated over last two pandemic years.
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- 2022
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19. Evolving Trends in the Management of Acute Appendicitis During COVID-19 Waves: The ACIE Appy II Study
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Pata, Francesco, Di Martino, Marcello, Podda, Mauro, Di Saverio, Salomone, Ielpo, Benedetto, Pellino, Gianluca, Julio, Abba, Alshamrani, Abdullah, Alturkistani, Abdullah, Alghamdi, Abdulrahman, Almalki, Abdulrahman, Orengia, Adam, Kuvvetli, Adnan, Pisanu, Adolfo, Smith, Adrian, Treviño Figueroa, Adriana Michelle, Nacion, Aeris Jane, Alhazmi, Ahmad, Bouhuwaish, Ahmad, Khalid, Ahmad, Alsufyani, Ahmed, Rubio, Ainhoa Valle, Bavikatte, Akshay, Kumar, Akshay, Jamiri, Al-Radjid, de San Ildefonso Pereira, Alberto, Porcu, Alberto, Sartori, Alberto, Rocca, Aldo, Sretenovic, Aleksandar, Anselmo, Alessandro, De Luca, Alessandro, Charalabopoulos, Alexandros, Tzivanakis, Alexios, Bandin, Alfonso, Nájar, Alfonso, Frontali, Alice, Faisal, Alsulaimani, Roldan, Amaia Martínez, Hamid, Amal, André, Ana, Minaya-Bravo, Ana, Das, Andre, Bondurri, Andrea, Costanzi, Andrea, Lucchi, Andrea, Mihailescu, Andrei, Police, Andrea, Zuchini, Andres Mendoza, Romano, Angela, Iossa, Angelo, Chessa, Antonella, Tromba, Antonella, Castaldi, Antonio, Brillantino, Antonio, Ferronetti, Antonio, Giuliani, Antonio, Ramos-De la Medina, Antonio, Tarasconi, Antonio, Picciariello, Arcangelo, Ioannidis, Argyrios, Leppäniemi, Ari, Rashid, Arshad, Mitul, Ashrarur Rahman, Mehraj, Asif, Laharwal, Asim, Iqbal, Atif, Liarakos, Athanasios, Marinis, Athanasios, de Andrés-Asenjo, Beatriz, Matías-García, Belén, De Simone, Belinda, Creavin, Ben, Stubbs, Ben, Goh, Brian, Jovanovic, Branislav, Sensi, Bruno, Gazia, Carlo, Cerdán, Carlos, Díaz, Carlos Javier Gómez, Chacón, Carlos Petrola, Yánez, Carlos, Faro, Carmelo Lo, Reinke, Caroline, Dominguez, Casandra, Paranjape, Charudutt, Thomas, Charlotte, Fung, Chia Chi, De Lucia, Chiara, Jennifer, Chiu Hiu Fung, Ovalle-Chao, Christian, Guerci, Claudio, Kenington, Cleo, Gica, Corina, Folliero, Cristina, Varela, Cristopher, Popowich, Daniel, Delogu, Daniele, Zigiotto, Daniele, Vinci, Danilo, D’Antonio, Dario, Merlini, David Alessio, Merlini, David, Moro-Valdezate, David, Keller, Deborah, Nicolaescu, Diana Cristiana, Sasia, Diego, Rodas, Edgar, Linardoutsos, Dimitrios, Russello, Domenico, Nájar-Castañeda, Pedro Alfonso, Stavrou, Habil Gregor, Rosso, Edoardo, Saladino, Edoardo, Ricciardi, Edoardo, Smith-Singares, Eduardo, Baili, Efstratia, Douka, Eleftheria, Guaitoli, Eleonora, Francone, Elisa, Vaterlini, Elisa Maria, Pierobon, Elisa Sefora, Morales, Emilio, Ros, Emilio Peña, Benzoni, Enrico, Erdas, Enrico, Pinotti, Enrico, Colás-Ruiz, Enrique, Laterza, Ernesto, Foianini, Esteban, Cardamone, Eugenia, Licardie, Eugenio, Marino, Fabio, Alsofyani, Fahad, Qahtani, Fahad, Khan, Farhan, Maraska, Fatlum, Saliu, Fatmir, Madrid, Fausto, Rosa, Fausto, Luvisetto, Federico, Alconchel, Felipe, Pareja-Ciuro, Felipe, Neves, Fernanda, Agresta, Ferdinando, Cordera, Fernando, Pardo, Fernando, Mendoza-Moreno, Fernando, Munoz-Flores, Fernando, Silvestri, Francesca Maria, Tropeano, Francesca Paola, Pecchini, Francesca, Serio, Francesca, Colombo, Francesco, Di Marzo, Francesco, Ferrara, Francesco, Lancellotti, Francesco, Litta, Francesco, Martini, Francesco, Roscio, Francesco, Blanco-Antona, Francisco, Barcenas, Francisco Javier Quezada, Schlottmann, Francisco, Herrera-Almario, Gabriel, van Ramshorst, Gabrielle, Gallo, Gaetano, Luglio, Gaetano, Kampouroglou, Georgios, Papadopoulos, Georgios, Arredondo, Gerardo, Calini, Giacomo, Formisano, Giampaolo, Galiffa, Giampaolo, Palini, Gian Marco, Colucci, Gianluca, Pagano, Gianluca, Vanni, Gianluca, Pattacini, Gianmaria Casoni, Gravante, Gianpiero, Lisi, Giorgio, Bellanova, Giovanni, De Nobili, Giovanni, Necchi, Giovanni Sammy, Sinibaldi, Giovanni, Bacchiocchi, Giulia, Bagaglini, Giulia, Maggi, Giulia, Izzo, Giuliano, Argenio, Giulio, Brisinda, Giuseppe, Esposito, Giuseppe, Frazzetta, Giuseppe, De Luca, Giuseppe Massimiliano, Nigri, Giuseppe, Sica, Giuseppe, Martin-Martin, Gonzalo, Ugon, Gustavo Armand, Martinez-Mier, Gustavo, Machain Vega, Gustavo Miguel, Nari, Gustavo, Nikaj, Herald, Neri, Ignacio, San Roman, Igor Alberdi, Fidoshev, Iliya, Martínez, Iñaki, Negoi, Ionut, Ortega, Irene, Vicente Rodríguez, Irune, Cornejo, Isabel, Mora-Guzmán, Ismael, al-Najami, Issam, Romic, Ivan, Balciscueta, Izaskun, Olivier, James, Lammel-Lindemann, Jan, Dziakova, Jana, Salinas, Javier, Jovanovic, Jelena Pejanovic, Reyes, Jeryl Anne Silvia, Salas, Joanne, Diaz-Elizondo, Jose Antonio, Parreira, Jose Gustavo, Bellido, Juan, Salamea, Juan, Martín del Olmo, Juan Carlos, Ordoñez, Juliana María, Junaid, Sofi, Davies, Justin, Sahnan, Kapil, Bekele, Kebebe, Voon, Kelvin, Siragusa, Leandro, Petagna, Lorenzo, Ferrario, Luca, Giordano, Luca, Nespoli, Luca, Pio, Luca, Moletta, Lucia, Curella, Luciano, Taglietti, Lucio, Bonavina, Luigi, Conti, Luigi, Pérez-Sánchez, Luis Eduardo, Cabrera Vargas, Luis Felipe, Sánchez-Guillén, Luis, Tallon-Aguilar, Luis, Khan, Mansoor, Spampinato, Marcello Giuseppe, Viola, Marcelo, Malet, Marcelo Viola, Angrisani, Marco, Calussi, Marco, Catarci, Marco, Giordano, Marco, Materazzo, Marco, Milone, Marco, Pellicciaro, Marco, Marino, Marco Vito, Moreno Villamizar, María Daniela, Lolli, Maria Giulia, Bellini, Maria Irene, Lemma, Maria, Chiarello, Maria Michela, Montes-Manrique, Mario, Rodriguez-Lopez, Mario, Serradilla-Martín, Mario, Peter, Mark, Paniagua-García-Señoráns, Marta, Rutegård, Martin, Salö, Martin, Silveri, Massimiliano, Veroux, Massimiliano, Nardi, Matteo, Rottoli, Matteo, Tolonen, Matti, Pedraza Ciro, Mauricio, Zuluaga, Mauricio, Iacobone, Maurizio, Montuori, Mauro, Ali, Mazin, García Domínguez, Melody, Paola, Menna Maria, Piccoli, Micaela, Campanelli, Michela, De Rosa, Michele, Manigrasso, Michele, Maruccia, Michele, Torre, Michele, Zuolo, Michele, Pera, Miguel, Weerasekera, Mihiri, Prieto, Mikel, Thway, Min Myat, Shaat, Mohamed, Azfar, Mohammad, Shalaby, Mostafa, Raza, Muhammad Asif, Younis, Muhammad Umar, Elhadi, Muhammed, Ali, Mujahid, Althomali, Musab, Al Amri, Nadiah, Dudi-Venkata, Nagendra, Alselaim, Nahar, Smart, Neil, Trelles, Nelson, Falco, Nicolò, Petrucciani, Niccolo, Antonacci, Nicola, Cillara, Nicola, Gica, Nicolae, Pecorelli, Nicolò, Tamini, Nicolò, Machairas, Nikolaos, Feituri, Nura, Ortega Torrecilla, Nuria, Avila Mercado, Octavio, Alaamer, Ohood, Irkorucu, Oktay, Alsherif, Omar, Buonomi, Oreste Claudio, Valles-Guerra, Orestes, Ioannidis, Orestis, Hernández Palmas, Oscar Isaac, Sanz Guadarrama, Oscar, Bozbiyik, Osman, Rodrigues, Pablo, Milito, Pamela, Panaccio, Paolo, Dorovinis, Panagiotis, Prieto, Paola, Baroffio, Paolo, Marsanic, Patrizia, Ajawin, Pawel, Koh, Peng Soon, Anoldo, Pietro, Major, Piotr, Alharthi, Qasem, Lui, Rashid, Caruso, Riccardo, Brady, Richard, Rattan, Rishi, Singhal, Rishi, Angelico, Roberta, Isernia, Roberta Maria, Tutino, Roberta, Peltrini, Roberto, Tejos, Rodrigo, Fajardo, Roosevelt, Elia, Rossella, Morales-Conde, Salvador, Benli, Sami, Fuentes, Sara, de las Casas, Sara Gortázar, de Guzmán Aragón, Sara Ortiz, Vertaldi, Sara, Awad, Selmy, Gentilli, Sergio, Weckmann Lujan, Sergio Alberto, Tayar, Serkan, Althobaiti, Shabab, Di Giovanni, Silvia, Ghedan, Soliman, Pérez-Bertólez, Sonia, Chiappetta, Sonja, Delis, Spiros, Scaringi, Stefano, Çetinkünar, Süleyman, Kykalos, Stylianos, Muhammad Ali, Syed, Krivan, Sylvia, Fung, Tak Lit Derek, Delko, Tarik, Nicolás López, Tatiana, De Campos, Tercio, Calderón Duque, Teresa, Perra, Teresa, Liakakos, Theodore, Daskalakis, Theodoros, Koëter, Tijmen, Zalla, Tiku, González, Tomás Elosua, Campagnaro, Tommaso, Oumar, Toure Alpha, Grossi, Ugo, Sosa, Valentina, Testa, Valentina, Tomajer, Valentina, Andriola, Valeria, Tonini, Valeria, Celentano, Valerio, Voglino, Valerio, Katta, Venkateswara Rao, García Orozco, Víctor Hugo, Turrado-Rodriguez, Victor, Visag-Castillo, Victor, Graham, Victoria, Rachkov, Viktor, Papagni, Vincenzo, Vigorita, Vincenzo, Jiménez Carneros, Virginia, Bellato, Vittoria, Bechstein, Wolf, Altinel, Yuksel, Balciscueta, Zutoia, Pata, Francesco, Di Martino, Marcello, Podda, Mauro, Di Saverio, Salomone, Ielpo, Benedetto, Pellino, Gianluca, Luglio, Gaetano, Pata, F, Di Martino, M, Podda, M, Di Saverio, S, Ielpo, B, Pellino, G, Julio, A, Alshamrani, A, Alturkistani, A, Alghamdi, A, Almalki, A, Orengia, A, Kuvvetli, A, Pisanu, A, Smith, A, Trevino Figueroa, A, Nacion, A, Alhazmi, A, Bouhuwaish, A, Khalid, A, Alsufyani, A, Rubio, A, Bavikatte, A, Kumar, A, Jamiri, A, de San Ildefonso Pereira, A, Porcu, A, Sartori, A, Rocca, A, Sretenovic, A, Anselmo, A, De Luca, A, Charalabopoulos, A, Tzivanakis, A, Bandin, A, Najar, A, Frontali, A, Faisal, A, Roldan, A, Hamid, A, Andre, A, Minaya-Bravo, A, Das, A, Bondurri, A, Costanzi, A, Lucchi, A, Mihailescu, A, Police, A, Zuchini, A, Romano, A, Iossa, A, Chessa, A, Tromba, A, Castaldi, A, Brillantino, A, Ferronetti, A, Giuliani, A, Ramos-De la Medina, A, Tarasconi, A, Picciariello, A, Ioannidis, A, Leppaniemi, A, Rashid, A, Mitul, A, Mehraj, A, Laharwal, A, Iqbal, A, Liarakos, A, Marinis, A, de Andres-Asenjo, B, Matias-Garcia, B, De Simone, B, Creavin, B, Stubbs, B, Goh, B, Jovanovic, B, Sensi, B, Gazia, C, Cerdan, C, Diaz, C, Chacon, C, Yanez, C, Faro, C, Reinke, C, Dominguez, C, Paranjape, C, Thomas, C, Fung, C, De Lucia, C, Jennifer, C, Ovalle-Chao, C, Guerci, C, Kenington, C, Gica, C, Folliero, C, Varela, C, Popowich, D, Delogu, D, Zigiotto, D, Vinci, D, D'Antonio, D, Merlini, D, Moro-Valdezate, D, Keller, D, Nicolaescu, D, Sasia, D, Rodas, E, Linardoutsos, D, Russello, D, Najar-Castaneda, P, Stavrou, H, Rosso, E, Saladino, E, Ricciardi, E, Smith-Singares, E, Baili, E, Douka, E, Guaitoli, E, Francone, E, Vaterlini, E, Pierobon, E, Morales, E, Ros, E, Benzoni, E, Erdas, E, Pinotti, E, Colas-Ruiz, E, Laterza, E, Foianini, E, Cardamone, E, Licardie, E, Marino, F, Alsofyani, F, Qahtani, F, Khan, F, Maraska, F, Saliu, F, Madrid, F, Rosa, F, Luvisetto, F, Alconchel, F, Pareja-Ciuro, F, Neves, F, Agresta, F, Cordera, F, Pardo, F, Mendoza-Moreno, F, Munoz-Flores, F, Silvestri, F, Tropeano, F, Pecchini, F, Serio, F, Colombo, F, Di Marzo, F, Ferrara, F, Lancellotti, F, Litta, F, Martini, F, Roscio, F, Blanco-Antona, F, Barcenas, F, Schlottmann, F, Herrera-Almario, G, van Ramshorst, G, Gallo, G, Luglio, G, Kampouroglou, G, Papadopoulos, G, Arredondo, G, Calini, G, Formisano, G, Galiffa, G, Palini, G, Colucci, G, Pagano, G, Vanni, G, Pattacini, G, Gravante, G, Lisi, G, Bellanova, G, De Nobili, G, Necchi, G, Sinibaldi, G, Bacchiocchi, G, Bagaglini, G, Maggi, G, Izzo, G, Argenio, G, Brisinda, G, Esposito, G, Frazzetta, G, De Luca, G, Nigri, G, Sica, G, Martin-Martin, G, Ugon, G, Martinez-Mier, G, Machain Vega, G, Nari, G, Nikaj, H, Neri, I, San Roman, I, Fidoshev, I, Martinez, I, Negoi, I, Ortega, I, Vicente Rodriguez, I, Cornejo, I, Mora-Guzman, I, al-Najami, I, Romic, I, Balciscueta, I, Olivier, J, Lammel-Lindemann, J, Dziakova, J, Salinas, J, Jovanovic, J, Reyes, J, Salas, J, Diaz-Elizondo, J, Parreira, J, Bellido, J, Salamea, J, Martin del Olmo, J, Ordonez, J, Junaid, S, Davies, J, Sahnan, K, Bekele, K, Voon, K, Siragusa, L, Petagna, L, Ferrario, L, Giordano, L, Nespoli, L, Pio, L, Moletta, L, Curella, L, Taglietti, L, Bonavina, L, Conti, L, Perez-Sanchez, L, Cabrera Vargas, L, Sanchez-Guillen, L, Tallon-Aguilar, L, Khan, M, Spampinato, M, Viola, M, Malet, M, Angrisani, M, Calussi, M, Catarci, M, Giordano, M, Materazzo, M, Milone, M, Pellicciaro, M, Marino, M, Moreno Villamizar, M, Lolli, M, Bellini, M, Lemma, M, Chiarello, M, Montes-Manrique, M, Rodriguez-Lopez, M, Serradilla-Martin, M, Peter, M, Paniagua-Garcia-Senorans, M, Rutegard, M, Salo, M, Silveri, M, Veroux, M, Nardi, M, Rottoli, M, Tolonen, M, Pedraza Ciro, M, Zuluaga, M, Iacobone, M, Montuori, M, Ali, M, Garcia Dominguez, M, Paola, M, Piccoli, M, Campanelli, M, De Rosa, M, Manigrasso, M, Maruccia, M, Torre, M, Zuolo, M, Pera, M, Weerasekera, M, Prieto, M, Thway, M, Shaat, M, Azfar, M, Shalaby, M, Raza, M, Younis, M, Elhadi, M, Althomali, M, Al Amri, N, Dudi-Venkata, N, Alselaim, N, Smart, N, Trelles, N, Falco, N, Petrucciani, N, Antonacci, N, Cillara, N, Gica, N, Pecorelli, N, Tamini, N, Machairas, N, Feituri, N, Ortega Torrecilla, N, Avila Mercado, O, Alaamer, O, Irkorucu, O, Alsherif, O, Buonomi, O, Valles-Guerra, O, Ioannidis, O, Hernandez Palmas, O, Sanz Guadarrama, O, Bozbiyik, O, Rodrigues, P, Milito, P, Panaccio, P, Dorovinis, P, Prieto, P, Baroffio, P, Marsanic, P, Ajawin, P, Koh, P, Anoldo, P, Major, P, Alharthi, Q, Lui, R, Caruso, R, Brady, R, Rattan, R, Singhal, R, Angelico, R, Isernia, R, Tutino, R, Peltrini, R, Tejos, R, Fajardo, R, Elia, R, Morales-Conde, S, Benli, S, Fuentes, S, de las Casas, S, de Guzman Aragon, S, Vertaldi, S, Awad, S, Gentilli, S, Weckmann Lujan, S, Tayar, S, Althobaiti, S, Di Giovanni, S, Ghedan, S, Perez-Bertolez, S, Chiappetta, S, Delis, S, Scaringi, S, Cetinkunar, S, Kykalos, S, Muhammad Ali, S, Krivan, S, Fung, T, Delko, T, Nicolas Lopez, T, De Campos, T, Calderon Duque, T, Perra, T, Liakakos, T, Daskalakis, T, Koeter, T, Zalla, T, Gonzalez, T, Campagnaro, T, Oumar, T, Grossi, U, Sosa, V, Testa, V, Tomajer, V, Andriola, V, Tonini, V, Celentano, V, Voglino, V, Katta, V, Garcia Orozco, V, Turrado-Rodriguez, V, Visag-Castillo, V, Graham, V, Rachkov, V, Papagni, V, Vigorita, V, Jimenez Carneros, V, Bellato, V, Bechstein, W, Altinel, Y, Balciscueta, Z, Institut Català de la Salut, [Pata F] General Surgery Unit, UOC di Chirurgia, Nicola Giannettasio Hospital, CS, Italy. La Sapienza University, Rome, Italy. [Di Martino M] Division of Hepatobiliary and Liver Transplantation Surgery, A.O.R.N. Cardarelli, Naples, Italy. [Podda M] Department of Surgical Science, University of Cagliari, Cagliari, Italy. [Di Saverio S] Department of Surgery, Madonna del Soccorso General Hospital, San Benedetto del Tronto, Italy. [Ielpo B] Hepatobiliary division, Hospital del Mar, Universitat Pompeu Fabra, Barcelona, Spain. [Pellino G] Department of Advanced Medical and Surgical Sciences, Universitá degli Studi della Campania ‘‘Luigi Vanvitelli’’, Policlinico CS, Naples, Italy. Unitat de Cirurgia de Còlon i Recte, Vall d’Hebron Hospital Universitari, Barcelona, Spain, and Vall d'Hebron Barcelona Hospital Campus
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Investigative Techniques::Epidemiologic Methods::Data Collection::Surveys and Questionnaires [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT] ,covid-19, surgery ,coronavirus ,sars-cov-2 ,appendicectomy ,laparoscopy ,nom ,management ,Enquestes ,Apendicectomia ,COVID-19 (Malaltia) ,surgery ,Surgical Procedures, Operative::Digestive System Surgical Procedures::Appendectomy [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT] ,Apendicitis ,Pandèmia de COVID-19, 2020 ,Appendectomy ,Humans ,Appendiciti ,Pandemics ,Cirurgia ,Pandemic ,SARS-CoV-2 ,COVID-19 ,Digestive System Diseases::Gastrointestinal Diseases::Gastroenteritis::Digestive System Diseases::Gastrointestinal Diseases::Appendicitis [DISEASES] ,Otros calificadores::Otros calificadores::/cirugía [Otros calificadores] ,técnicas de investigación::métodos epidemiológicos::recopilación de datos::encuestas y cuestionarios [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS] ,Appendicitis ,Apendicitis - Cirurgia ,Other subheadings::Other subheadings::/surgery [Other subheadings] ,Settore MED/18 ,Settore MED/18 - Chirurgia Generale ,Acute Disease ,enfermedades del sistema digestivo::enfermedades gastrointestinales::gastroenteritis::enfermedades del sistema digestivo::enfermedades gastrointestinales::apendicitis [ENFERMEDADES] ,intervenciones quirúrgicas::procedimientos quirúrgicos del sistema digestivo::apendicectomía [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS] ,Human - Abstract
Background In 2020, ACIE Appy study showed that COVID-19 pandemic heavily affected the management of patients with acute appendicitis (AA) worldwide, with an increased rate of non-operative management (NOM) strategies and a trend toward open surgery due to concern of virus transmission by laparoscopy and controversial recommendations on this issue. The aim of this study was to survey again the same group of surgeons to assess if any difference in management attitudes of AA had occurred in the later stages of the outbreak. Methods From August 15 to September 30, 2021, an online questionnaire was sent to all 709 participants of the ACIE Appy study. The questionnaire included questions on personal protective equipment (PPE), local policies and screening for SARS-CoV-2 infection, NOM, surgical approach and disease presentations in 2021. The results were compared with the results from the previous study. Results A total of 476 answers were collected (response rate 67.1%). Screening policies were significatively improved with most patients screened regardless of symptoms (89.5% vs. 37.4%) with PCR and antigenic test as the preferred test (74.1% vs. 26.3%). More patients tested positive before surgery and commercial systems were the preferred ones to filter smoke plumes during laparoscopy. Laparoscopic appendicectomy was the first option in the treatment of AA, with a declined use of NOM. Conclusion Management of AA has improved in the last waves of pandemic. Increased evidence regarding SARS-COV-2 infection along with a timely healthcare systems response has been translated into tailored attitudes and a better care for patients with AA worldwide.
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- 2022
20. Opportunistic Quantitative Computed Tomography Assessing Bone Mineral Density in Patients With Laparoscopic Roux-En-Y-Gastric Bypass Metabolic Surgery Throughout a 5-Year Observation Window.
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Noser MS, Boll DT, Lazaridis II, Delko T, Koestler T, Zingg U, and Potthast S
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Background: Bariatric surgery is associated with decreasing bone mineral density (BMD)., Objective: To assess the long-term vertebral BMD, measured by opportunistic quantitative CT (QCT), and body mass index (BMI) in patients undergoing proximal laparoscopic Roux-en-Y surgery (LRYGB)., Methods: In 62 patients undergoing LRYGB, opportunistic QCT measurements were performed extracting BMD and BMI on day 1 and years 1, 3, and 5 postoperatively.Primarily, one-way analyses of variance were performed on dependent variables BMI and BMD, with imaging interval defined as an independent factor. Student-Newman-Keuls tests performed pairwise comparisons of imaging interval permutations for BMI/BMD.Secondarily, analyses of covariance were used on dependent variables BMI and BMD, with imaging interval as an independent factor and gender/age as well as BMD/BMI, respectively, as covariates., Results: A total of 227 opportunistic QCT measurements in 62 patients were performed without the need of a phantom or extra software.The BMD decreased substantially and continuously during 1-, 3-, and 5-year follow-up observations, reaching statistical significance in pairwise comparisons for 3- and 5-year follow-up visits compared to initial BMD values as well as the 5-year follow-up visit compared to the 1-year BMD values, P < 0.001. Age and BMI were significant covariates, P < 0.001.The BMI decreased within 1 year and stayed constant until a slight increase at 5 years was observed. Statistical significance in pairwise comparisons for first-year and 3- and 5-year follow-up visits was reached compared to initial BMI values, P < 0.001. For the BMI assessment, none of the covariates reached statistical significance., Conclusion: Opportunistic QCT is suited for the calculation and follow-up of BMD. There was a continuous decrease of BMD after LRYGB over 5 years post-surgery, whereas BMI decreased in the first year and stayed constant thereafter. Older patients with lower BMI seem particularly prone to an accelerated BMD loss., Competing Interests: The authors declare no conflict of interest., (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)
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- 2024
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21. Laparoscopic Roux-Y-gastric bypass versus laparoscopic one-anastomosis gastric bypass for obesity: clinical & metabolic results of a prospective randomized controlled trial.
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Delko T, Kraljević M, Lazaridis II, Köstler T, Jomard A, Taheri A, Lutz TA, Osto E, and Zingg U
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- Humans, Female, Male, Prospective Studies, Adult, Middle Aged, Weight Loss, Obesity, Morbid surgery, Treatment Outcome, Postoperative Complications epidemiology, Postoperative Complications etiology, Gastric Bypass methods, Laparoscopy methods
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Background: One anastomosis gastric bypass (OAGB) has been proposed as an effective alternative to the current standard procedure in Switzerland, Roux-en-Y gastric bypass (RYGB). Prospective data comparing both procedures are scarce. Therefore, we performed a non-inferiority randomized controlled trial assessing the effectiveness and safety of these 2 operative techniques., Method: Eighty patients were randomized 1:1. OAGB consisted of a very long gastric pouch with a 200 cm biliopancreatic limb, RYGB of a 150 cm ante-colic alimentary and a 60 cm biliopancreatic limb, respectively. Primary endpoint was the percent excess weight loss (%EWL) at 12 months after surgery., Results: Mean %EWL at 12 months was 87.9% (SD24.4) in the RYGB group and 104.1% (SD24.6) in the OAGB group (p = 0.006). There was no mortality. The rate of marginal ulcers was higher in patients with OAGB compared to those with RYGB (p = 0.011), while the total number of late complications did not statistically differ between the two groups. Except for the remission of GERD, which was higher in the RYGB group compared to OAGB, there was no difference between the groups regarding the remission of comorbidities. OAGB showed improved glucose control compared to the RYGB after 1 year (p = 0.001). Furthermore, glucagon-like peptide-1 increase was significantly higher in OAGB at 6 weeks (p = 0.041) and 1 year after surgery (p = 0.029). Quality of life improved after both surgeries, without differences between the groups., Conclusions: %EWL 1 year after surgery was higher in OAGB than in RYGB. A better glycemic control with a higher increase in GLP-1 was observed after OAGB compared to RYGB., Trial Registration: This trial is registered on ClinicalTrials.gov under the identifier NCT02601092., (© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
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- 2024
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22. Metabolic outcomes in obese mice undergoing one-anastomosis gastric bypass (OAGB) with a long or a short biliopancreatic limb.
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Lazaridis II, Bosch AJT, Keller L, Low AJY, Tamarelle J, Moser SO, Winter DV, Gómez C, Peterson CJ, Schneider R, Kraljević M, Odermatt A, Vonaesch P, Peterli R, Delko T, and Cavelti-Weder C
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- Animals, Male, Mice, Diet, High-Fat, Gastrointestinal Microbiome physiology, Anastomosis, Surgical, Obesity, Morbid surgery, Obesity, Morbid metabolism, Bile Acids and Salts metabolism, Gastric Bypass, Mice, Inbred C57BL, Weight Loss physiology, Mice, Obese, Obesity surgery, Obesity metabolism
- Abstract
One-anastomosis gastric bypass (OAGB) has gained importance as a simple, safe, and effective operation to treat morbid obesity. We previously found that Roux-en-Y gastric bypass surgery with a long compared with a short biliopancreatic limb (BPL) leads to improved weight loss and glucose tolerance in obese mice. However, it is not known whether a long BPL in OAGB surgery also results in beneficial metabolic outcomes. Five-week-old male C57BL/6J mice fed a high-fat diet (HFD) for 8 weeks underwent OAGB surgery with defined BPL lengths (5.5 cm distally of the duodenojejunal junction for short and 9.5 cm for long BPL), or sham surgery combined with caloric restriction. Weight loss, glucose tolerance, obesity-related comorbidities, endocrine effects, gut microbiota, and bile acids were assessed. Total weight loss was independent of the length of the BPL after OAGB surgery. However, a long BPL was associated with lower glucose-stimulated insulin on day 14 , and an improved glucose tolerance on day 35 after surgery. Moreover, a long BPL resulted in reduced total cholesterol, while there were no differences in the resolution of metabolic dysfunction-associated steatotic liver disease (MASLD) and adipose tissue inflammation. Tendencies of an attenuated hypothalamic-pituitary-adrenal (HPA) axis and aldosterone were present in the long BPL group. With both the short and long BPL, we found an increase in primary conjugated bile acids (pronounced in long BPL) along with a loss in bacterial Desulfovibrionaceae and Erysipelotrichaceae and simultaneous increase in Akkermansiaceae , Sutterellaceae , and Enterobacteriaceae . In summary, OAGB surgery with a long compared with a short BPL led to similar weight loss, but improved glucose metabolism, lipid, and endocrine outcomes in obese mice, potentially mediated through changes in gut microbiota and related bile acids. Tailoring the BPL length in humans might help to optimize metabolic outcomes after bariatric surgery. NEW & NOTEWORTHY Weight loss following OAGB surgery in obese mice was not influenced by BPL length, but a longer BPL was associated with improved metabolic outcomes, including glucose and lipid homeostasis. These changes could be mediated by bile acids upon altered gut microbiota. Further validation of these findings is required through a randomized human study.
- Published
- 2024
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23. High density of CXCL12-positive immune cell infiltration predicts chemosensitivity and recurrence-free survival in ovarian carcinoma.
- Author
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Köhn P, Lalos A, Posabella A, Wilhelm A, Tampakis A, Caner E, Güth U, Stadlmann S, Spagnoli GC, Piscuoglio S, Richarz S, Delko T, Droeser RA, and Singer G
- Subjects
- Humans, Female, Carcinoma, Ovarian Epithelial, Prognosis, Biomarkers, Tumor metabolism, Chemokine CXCL12, Ovarian Neoplasms pathology, Carcinoma, Cystadenocarcinoma, Serous pathology
- Abstract
Background: Ovarian carcinoma is the most lethal gynecologic malignancy because of its late diagnosis, extremely high recurrence rate, and limited curative treatment options. In clinical practice, high-grade serous carcinoma (HGSC) predominates due to its frequency, high aggressiveness, and rapid development of drug resistance. Recent evidence suggests that CXCL12 is an important immunological factor in ovarian cancer progression. Therefore, we investigated the predictive and prognostic significance of the expression of this chemokine in tumor and immune cells in patients with HGSC., Methods: We studied a cohort of 47 primary high-grade serous ovarian carcinomas and their associated recurrences. A tissue microarray was constructed to evaluate the CXCL12 immunostained tumor tissue. CXCL12 expression was evaluated and statistically analyzed to correlate clinicopathologic data, overall survival, and recurrence-free survival., Results: A high proportion of CXCL12 + positive immune cells in primary ovarian serous carcinoma correlated significantly with chemosensitivity (p = 0.005), overall survival (p = 0.021), and longer recurrence-free survival (p = 0.038). In recurrent disease, high expression of CXCL12 was also correlated with better overall survival (p = 0.040). Univariate and multivariate analysis revealed that high CXCL12 + tumor-infiltrating immune cells (TICs) (HR 0.99, p = 0.042, HR 0.99, p = 0.023, respectively) and combined CXCL12 + /CD66b + infiltration (HR 0.15, p = 0.001, HR 0.13, p = 0.001, respectively) are independent favorable predictive markers for recurrence-free survival., Conclusion: A high density of CXCL12 + TICs predicts a good response to chemotherapy, leading to a better overall survival and a longer recurrence-free interval. Moreover, with concomitant high CXCL12/CD66b TIC density, it is an independent favorable predictor of recurrence-free survival in patients with ovarian carcinoma., (© 2023. The Author(s).)
- Published
- 2023
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24. Bariatric Surgery and Metabolic Dysfunction-Associated Fatty Liver Disease: a 2022 Update.
- Author
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Lazaridis II and Delko T
- Subjects
- Humans, Obesity complications, Obesity surgery, Non-alcoholic Fatty Liver Disease diagnosis, Non-alcoholic Fatty Liver Disease surgery, Bariatric Surgery, Metabolic Syndrome complications, Metabolic Syndrome surgery
- Abstract
Non-alcoholic fatty liver disease (NAFLD) has been recently termed metabolic dysfunction-associated fatty liver disease (MAFLD) to address the strong association with the metabolic syndrome. The prevalence of MAFLD is significantly increased in obese individuals and treatment of obesity is currently the cornerstone of management of MAFLD. Bariatric and metabolic surgery nowadays emerges as a key therapeutic strategy for the treatment of the MAFLD. This review aims to provide an update on the novel studies reporting the outcomes of bariatric surgery on the spectrum of MAFLD, from hepatic steatosis to cirrhosis.
- Published
- 2023
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25. Incidence and risk factors of symptomatic Petersen's hernias in bariatric and upper gastrointestinal surgery: a systematic review and meta-analysis.
- Author
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Apostolou KG, Lazaridis II, Kanavidis P, Triantafyllou M, Gkiala A, Alexandrou A, Ntourakis D, Delko T, and Schizas D
- Subjects
- Humans, Incidence, Risk Factors, Retrospective Studies, Gastric Bypass adverse effects, Hernia, Abdominal surgery, Intestinal Obstruction epidemiology, Intestinal Obstruction etiology, Intestinal Obstruction surgery, Laparoscopy adverse effects, Bariatrics adverse effects, Obesity, Morbid complications, Obesity, Morbid surgery
- Abstract
Purpose: The aim of this study was to investigate the actual incidence of symptomatic Petersen's hernias (PH) as well as identify risk factors for their occurrence., Methods: Search was performed in Medline (via PubMed), Web of Science, and Cochrane library, using the keywords "Petersen Or Petersen's AND hernia" and "Internal hernia." Only studies of symptomatic PH were eligible. Fifty-three studies matched our criteria and were included. Risk of bias for each study was independently assessed using the checklist modification by Hoy et al. Analysis was performed using random-effects models, with subsequent subgroup analyses., Results: A total of 81,701 patients were included. Mean time interval from index operation to PH diagnosis was 17.8 months. Total small bowel obstruction (SBO) events at Petersen's site were 737 (0.7%). SBO incidence was significantly higher in patients without defect closure (1.2% vs 0.3%, p < 0.01), but was not significantly affected by anastomosis fashion (retrocolic 0.7% vs antecolic 0.8%, p = 0.99). SBO incidence was also not significantly affected by the surgical approach (laparoscopic = 0.7% vs open = 0.1%, p = 0.18). However, retrocolic anastomosis was found to be associated with marginally, but not significantly, increased SBO rate in patients with Petersen's space closure, compared with the antecolic anastomosis (p = 0.09)., Conclusion: PH development may occur after any gastric operation with gastrojejunal anastomosis. Contrary to anastomosis fashion and surgical approach, defect closure was demonstrated to significantly reduce SBO incidence. Limitations of this study may include the high heterogeneity and the possible publication bias across the included studies., (© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
- Published
- 2023
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26. Intraoperative Patterns of Gastric Microperfusion During Laparoscopic Roux-en-Y Gastric Bypass.
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Lazaridis II, Schneider R, Stocker R, Kraljević M, Klasen JM, and Delko T
- Subjects
- Humans, Stomach surgery, Gastric Bypass methods, Obesity, Morbid surgery, Laparoscopy methods, Abdominal Wall surgery
- Abstract
Introduction: Visible light spectroscopy (VLS) represents a sensitive, non-invasive method to quantify tissue oxygen levels and detect hypoxemia. The aim of this study was to assess the microperfusion patterns of the gastric pouch during laparoscopic Roux-en-Y gastric bypass (LRYGB) using the VLS technique., Methods: Twenty patients were enrolled. Tissue oxygenation (StO2%) measurements were performed at three different localizations of the gastric wall, prior and after the creation of the gastric pouch, and after the creation of the gastro-jejunostomy., Results: Prior to the creation of the gastric pouch, the lowest StO2% levels were observed at the level of the distal esophagus with a median StO2% of 43 (IQR 40.8-49.5). After the creation of the gastric pouch and after the creation of the gastro-jejunostomy, the lowest StO2% levels were recorded at the level of the His angle with median values of 29% (IQR 20-38.5) and 34.5% (IQR 19-39), respectively. The highest mean StO2 reduction was recorded at the level of the His angle after the creation of the gastric pouch, and it was 18.3% (SD ± 18.1%, p < 0.001). A reduction of StO2% was recorded at all localizations after the formation of the gastro-jejunostomy compared to the beginning of the operation, but the mean differences of the StO2% levels were statistically significant only at the resection line of the pouch and at the His angle (p = 0.044 and p < 0.001, respectively)., Conclusion: Gastric pouch demonstrates reduction of StO2% during LRYGB. VLS is a useful technique to assess microperfusion patterns of the stomach during LRYGB., (© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
- Published
- 2022
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27. The prognostic significance of CXCR4 and SDF-1 in differentiated thyroid cancer depends on CD8+ density.
- Author
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Wilhelm A, Lemmenmeier I, Lalos A, Posabella A, Kancherla V, Piscuoglio S, Delko T, von Flüe M, Glatz K, and Droeser RA
- Subjects
- Humans, CD8-Positive T-Lymphocytes metabolism, Prognosis, Receptors, CXCR4 genetics, Thyroid Cancer, Papillary genetics, Tumor Microenvironment, Chemokine CXCL12 metabolism, Adenocarcinoma, Thyroid Neoplasms diagnosis, Thyroid Neoplasms genetics, Thyroid Neoplasms metabolism
- Abstract
Background: Tumor infiltration with cytotoxic CD8+ T-cells is associated with a favorable outcome in several neoplasms, including thyroid cancer. The chemokine axis CXCR4/SDF-1 correlates with more aggressive tumors, but little is known concerning the prognostic relevance in relation to the tumor immune microenvironment of differentiated thyroid cancer (DTC)., Methods: A tissue microarray (TMA) of 37 tumor specimens of primary DTC was analyzed by immunohistochemistry (IHC) for the expression of CD8+, CXCR4, phosphorylated CXCR4 and SDF-1. A survival analysis was performed on a larger collective (n = 456) at RNA level using data from The Cancer Genome Atlas (TCGA) papillary thyroid cancer cohort., Results: Among the 37 patients in the TMA-cohort, the density of CD8+ was higher in patients with less advanced primary tumors (median cells/TMA-punch: 12.5 (IQR: 6.5, 12.5) in T1-2 tumors vs. 5 (IQR: 3, 8) in T3-4 tumors, p = 0.05). In the TCGA-cohort, CXCR4 expression was higher in patients with cervical lymph node metastasis compared to N0 or Nx stage (CXCR4
high/low 116/78 vs. 97/116 vs. 14/35, respectively, p = 0.001). Spearman's correlation analysis of the TMA-cohort demonstrated that SDF-1 was significantly correlated with CXCR4 (r = 0.4, p = 0.01) and pCXCR4 (r = 0.5, p = 0.002). In the TCGA-cohort, density of CD8+ correlated with CXCR4 and SDF-1 expression (r = 0.58, p < 0.001; r = 0.4, p < 0.001). The combined marker analysis of the TCGA cohort demonstrated that high expression of both, CXCR4 and SDF-1 was associated with reduced overall survival in the CD8 negative TCGA cohort (p = 0.004)., Conclusion: These findings suggest that the prognostic significance of CXCR4 and SDF-1 in differentiated thyroid cancer depends on the density of CD8 positive T-lymphocytes. Further studies with larger sample sizes are needed to support our findings and inform future investigations of new treatment and diagnostic options for a more personalized approach for patients with differentiated thyroid cancer., (© 2022. The Author(s).)- Published
- 2022
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28. Roux-en-Y gastric bypass with a long versus a short biliopancreatic limb improves weight loss and glycemic control in obese mice.
- Author
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Schneider R, Kraljević M, Peterli R, Rohm TV, Bosch AJT, Low AJY, Keller L, AlAsfoor S, Häfliger S, Yilmaz B, Peterson CJ, Lazaridis II, Vonaesch P, Delko T, and Cavelti-Weder C
- Subjects
- Male, Humans, Mice, Animals, Mice, Obese, Glycemic Control, Mice, Inbred C57BL, Weight Loss, Obesity surgery, Glucose, Gastric Bypass methods, Obesity, Morbid surgery
- Abstract
Background: Roux-en-Y gastric bypass (RYGB) results in long-term weight loss and reduced obesity related co-morbidities. However, little is known about how the lengths of the biliopancreatic limb (BPL), the alimentary limb (AL), and the common limb (CL) affect weight loss and glucose metabolism., Objectives: Our aim was to establish a RYGB obese mouse model with defined proportions of the AL and BPL and a constant CL to assess the effects on weight loss,glucose metabolism, and obesity-related co-morbidities., Setting: In vivo mouse study., Methods: Six-week-old male C57BL/6J mice fed with a high-fat diet (HFD) underwent bariatric surgery with defined BPL lengths: a very long, long, and short BPL (35%, 25%, and 15% of total bowel length), or sham surgery. The length of the AL was adjusted to achieve the same CL length. Mice were analyzed for weight loss, glycemic control, and obesity-related co-morbidities., Results: Mice undergoing RYGB surgery with a very long BPL had excessive weight loss and mortality and were therefore not further analyzed. Mice with a long BPL showed a significantly increased total weight loss when compared with mice with a short BPL. In addition, a long BPL improved glucose tolerance, particularly early after surgery. A long BPL was also associated with lower triglyceride levels. Resolution of hepatic steatosis and adipose tissue inflammation was, however, not statistically significant. Of note, bariatric surgery dramatically changed gut microbiota, regardless of limb length., Conclusion: In obese mice, a long BPL results in enhanced weight loss and improved glucose tolerance. These findings could potentially be translated to humans by tailoring the BPL length according to body weight, obesity-related co-morbidities, and total bowel length of an individual patient., (Copyright © 2022 American Society for Metabolic and Bariatric Surgery. Published by Elsevier Inc. All rights reserved.)
- Published
- 2022
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29. Risk of Reopening of the Mesenteric Defects After Routine Closure in Laparoscopic Roux-en-Y Gastric Bypass: a Single-Centre Experience.
- Author
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Lazaridis II, Köstler T, Kübler L, Zingg U, and Delko T
- Subjects
- Humans, Postoperative Complications etiology, Postoperative Complications surgery, Retrospective Studies, Gastric Bypass adverse effects, Hernia, Abdominal etiology, Intestinal Obstruction complications, Intestinal Obstruction surgery, Laparoscopy adverse effects, Obesity, Morbid surgery
- Abstract
Purpose: Small bowel obstruction (SBO) due to internal hernias (IH) is a well-recognised complication after laparoscopic Roux-en-Y gastric bypass (LRYGB). Routine closure of the mesenteric defects (MDs) is recommended to reduce the risk of IH and subsequent SBO. However, data about the rates of reopening of the MDs after LRYGB is scarce. The main aim of this study was to evaluate the risk of reopening of the MDs after routine closure during LRYGB. The secondary objective was to determine any risk factors associated with the reopening of the MDs., Methods: Data of all patients who underwent reoperations after LRYGB with closure of both MDs between January 2010 and December 2018 were retrospectively reviewed., Results: A total of 162 patients were included. The median time between LRYGB and reoperation was 17 months. At the time of reoperation, both MDs were closed in 83 patients (51.2%); thus, 79 patients (48.8%) presented at least one open MD. The group of patients with preoperative diagnosis of SBO or with recurrent abdominal pain showed significantly higher rates of open Petersen's space compared to the group of patients with other preoperative diagnoses. Preoperative body mass index (BMI) less than 40 kg/m
2 at time of LRYGB was associated with a higher risk for an open MD., Conclusion: At least one MD reopened in almost half of the patients despite routine closure during LRYGB. Therefore, the status of MDs should be routinely examined during every reoperation after LRYGB and closure of open MDs should be performed., (© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)- Published
- 2022
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30. The Impact of the COVID-19 Pandemic on Patients from a Bariatric Program: A Qualitative Analysis of Their Perceptions of Health and Well-Being.
- Author
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Klasen JM, Tynes DM, Peterson CJ, Schneider R, Timper K, Peterli R, Randall CL, and Delko T
- Abstract
Introduction: The study was conducted to explore the perceptions of patients from a bariatric program who have undergone or will undergo bariatric surgery during the ongoing COVID-19 pandemic, specifically as related to their struggles with health issues and their psychological well-being., Materials and Methods: We conducted semi-structured, in-depth interviews with nineteen pre- or post-bariatric patients to generate data on their perceptions of COVID-19. Consistent with the methods of constructivist grounded theory, we collected and analyzed data iteratively through a constant comparative process for data coding and develop themes in the transcripts., Results: We identified themes to summarize the pandemic-associated experiences of our cohort as follows: their life structure before COVID-19, the turning point with changes and adaptations, and the impact of isolation on psychological well-being. We identified grief due to loss of social contacts as well as physical and psychological health impairment as consequences of pandemic-related lifestyle changes. Most participants were not aware of overweight and obesity being major risk factors for worse outcomes of COVID-19. We developed a theme-based theory on patients' perceptions and fears regarding the pandemic as they live through phases of grief., Discussion: Most participants shared critical perceptions about their own somatic and psychological health. These findings may inform recommendations and strategies for both patients and healthcare professionals to manage the challenges potentially presented by this vulnerable patient group in the context of the COVID-19 pandemic.
- Published
- 2022
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31. Rare case of an 83-year-old woman with transrectal small bowel evisceration caused by spontaneous rectal perforation.
- Author
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Wiesler B, Linke KS, and Delko T
- Subjects
- Aged, 80 and over, Female, Humans, Intestine, Small diagnostic imaging, Intestine, Small surgery, Rectum surgery, Intestinal Perforation diagnostic imaging, Intestinal Perforation etiology, Intestinal Perforation surgery, Rectal Diseases diagnostic imaging, Rectal Diseases etiology, Rectal Diseases surgery, Rectal Prolapse surgery
- Abstract
Spontaneous rectal perforation with transanal small intestinal evisceration is a rare condition. We report the case of an 83-year-old woman with a rectal perforation and transanal prolapse of small intestine through the rectal opening who was treated with transanal reposition under general anaesthesia and open Hartmann's procedure. As part of the Hartmann's procedure, segmental resection of the perforated colon was performed. This case illustrates that spontaneous rectal perforation is a severe surgical emergency, which needs immediate reposition and resection of the perforated rectum., Competing Interests: Competing interests: None declared., (© BMJ Publishing Group Limited 2022. No commercial re-use. See rights and permissions. Published by BMJ.)
- Published
- 2022
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32. Revisional Adjustable Gastric Band in Roux-en-Y Gastric Bypass-Is It Worth It?
- Author
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Lazaridis II, Kraljević M, Süsstrunk J, Köstler T, Zingg U, and Delko T
- Subjects
- Body Mass Index, Humans, Retrospective Studies, Treatment Outcome, Gastric Bypass, Gastroplasty, Laparoscopy, Obesity, Morbid surgery, Reoperation
- Abstract
Purpose: A subset of patients undergoing Roux-en-Y gastric bypass (RYGB) presents with either insufficient weight loss or weight regain. Data on the revisional restrictive options including laparoscopic adjustable gastric band (LAGB) is scarce. This study analyzes the mid-term efficacy and safety of LAGB as a revisional procedure after RYGB., Methods: Data of all patients with revisional LAGB after primary RYGB between January 2011 and May 2019 were retrospectively reviewed. Outcomes included assessment of weight changes, resolution of comorbidities, and early and late complications during the study period., Results: Twenty patients were included. The median Body Mass Index (BMI) before revisional LAGB was 34.8 (interquartile range [IQR] 31.9-38.1) kg/m
2 . After a median follow-up of 33.5 (IQR 19.5-76.5) months, the median BMI was 28.7 (IQR 26.1-32.2) kg/m2 . The median additional Excess Weight Loss (EWL) was 37.6% (IQR 23-44.4), leading to a median total EWL of 79.5% (IQR 54.4-94.6). BMI and EWL post-LAGB improved significantly compared to BMI and EWL pre-LAGB (p<0.001 and p<0.001, respectively). Obstructive sleep apnea syndrome resolved 6 months after LAGB in one patient. Three band deflations occurred during the follow-up. Six patients underwent band removal after a median time of 19 (IQR 15.8-26) months. Overall, thirteen patients underwent a reoperation. There was no loss of follow-up until 5 years. After that, two patients were lost to follow-up., Conclusion: LAGB may be a salvage option after failed RYGB. However, the high rate of revisions after secondary LAGB needs to be taken into consideration., (© 2021. The Author(s).)- Published
- 2021
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33. Nestin and CD34 expression in colorectal cancer predicts improved overall survival.
- Author
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Tampakis A, Weixler B, Rast S, Tampaki EC, Cremonesi E, Kancherla V, Tosti N, Kettelhack C, Ng CKY, Delko T, Soysal SD, von Holzen U, Felekouras E, Nikiteas N, Bolli M, Tornillo L, Terracciano L, Eppenberger-Castori S, Spagnoli GC, Piscuoglio S, von Flüe M, Däster S, and Droeser RA
- Subjects
- Antigens, CD34, Humans, Immunohistochemistry, Nestin genetics, Colorectal Neoplasms genetics, Neovascularization, Pathologic
- Abstract
Background: Nestin, a class VI intermediate filament protein of the cytoskeleton, and CD34, a transmembrane phosphoglycoprotein, are markers of progenitor cells. This study aimed to evaluate their expression and clinical significance in colorectal cancer., Methods: A clinically annotated tissue microarray, including 599 patients with colorectal cancer, was analyzed by immunohistochemistry. Furthermore, nestin and CD34 correlations with HIF-1a and a panel of cytokines and chemokines were assessed using quantitative reverse transcription PCR and The Cancer Genome Atlas dataset., Results: Expression of nestin and CD34 was observed only in the tumor stroma. Patients displaying high expression of nestin and CD34 demonstrated higher rates of T1 and T2 tumors ( p = .020), lower vascular invasion ( p < .001) and improved 5-year overall survival (65%; 95% CI = 55-73 vs 45%; 95% CI = 37-53) after adjusting for clinicopathological characteristics (HR: 0.67; 95% CI = 0.46-0.96). A moderate to strong correlation ( r = 0.37-0.78, p < .03) of nestin and CD34 was demonstrated for the following markers; HIF-1α, CD4, CD8, FOXP3, IRF1, GATA3, CCL2, CCL3, CXCL12 and CCL21., Conclusions: Combined expression of nestin and CD34 expression is associated with better overall survival possibly by modulating a favorable immune response.
- Published
- 2021
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34. Different limb lengths in gastric bypass surgery: study protocol for a Swiss multicenter randomized controlled trial (SLIM).
- Author
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Kraljević M, Schneider R, Wölnerhanssen B, Bueter M, Delko T, and Peterli R
- Subjects
- Body Mass Index, Humans, Multicenter Studies as Topic, Quality of Life, Randomized Controlled Trials as Topic, Switzerland, Treatment Outcome, Diabetes Mellitus, Type 2, Gastric Bypass adverse effects, Obesity, Morbid diagnosis, Obesity, Morbid surgery
- Abstract
Background: Obesity and type 2 diabetes mellitus are reaching epidemic proportions. In morbidly obese patients, bariatric operations lead to sustained weight loss and relief of comorbidities in the majority of patients. Laparoscopic Roux-Y-gastric bypass (RYGB) is one of the most frequently performed operations, but it is still unknown why some patients respond better than others. Therefore, a number of variations of this operation have been introduced. Recent evidence suggests that a longer bypassed biliopancreatic limb (BPL) has the potential to be more effective compared to the standard RYGB with a shorter BPL length. This article describes the design and protocol of a randomized controlled trial comparing the outcome of a RYGB operation with a long versus short BPL., Methods/design: The trial is designed as a multicenter, randomized, patient- and observer-blinded trial. The relevant ethics committee has approved the trial protocol. To demonstrate that long BPL RYGB is superior compared to short BPL RYGB in terms of weight loss and resolution of T2DM, the study is conducted as a superiority trial. Postoperative percent total weight loss and nutritional deficiency rate are the primary endpoints, whereas morbidity, mortality, remission of obesity-related comorbidities and quality of life are secondary endpoints. Eight hundred patients, between 18 and 65 years and with a body mass index (BMI) from 35 to 60 kg/m
2 who meet the regulatory rules for bariatric surgery in Switzerland, will be randomized. The endpoints and baseline measurements will be assessed pre-, intra-, and postoperatively., Discussion: With its high number of patients and a 5-year follow-up, this study will answer questions about effectiveness and safety of long BPL RYGB and provide level I evidence for improvement of the standard RYGB. These findings might therefore potentially influence global bariatric surgery guidelines., Trial Registration: ClinicalTrials.gov NCT04219787 . Registered on 7 January 2020.- Published
- 2021
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35. Obesity in Humans Is Characterized by Gut Inflammation as Shown by Pro-Inflammatory Intestinal Macrophage Accumulation.
- Author
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Rohm TV, Fuchs R, Müller RL, Keller L, Baumann Z, Bosch AJT, Schneider R, Labes D, Langer I, Pilz JB, Niess JH, Delko T, Hruz P, and Cavelti-Weder C
- Subjects
- Body Mass Index, Case-Control Studies, Diet adverse effects, Female, Gastroenteritis metabolism, Humans, Inflammation Mediators metabolism, Macrophages metabolism, Male, Middle Aged, Obesity complications, Obesity metabolism, Phenotype, Prospective Studies, Risk Assessment, Risk Factors, Sedentary Behavior, Gastroenteritis immunology, Immunity, Innate, Immunity, Mucosal, Intestines immunology, Macrophages immunology, Obesity immunology
- Abstract
Chronic low-grade inflammation is a hallmark of obesity and associated with cardiovascular complications. However, it remains unclear where this inflammation starts. As the gut is constantly exposed to food, gut microbiota, and metabolites, we hypothesized that mucosal immunity triggers an innate inflammatory response in obesity. We characterized five distinct macrophage subpopulations (P1-P5) along the gastrointestinal tract and blood monocyte subpopulations (classical, non-classical, intermediate), which replenish intestinal macrophages, in non-obese (BMI<27kg/m
2 ) and obese individuals (BMI>32kg/m2 ). To elucidate factors that potentially trigger gut inflammation, we correlated these subpopulations with cardiovascular risk factors and lifestyle behaviors. In obese individuals, we found higher pro-inflammatory macrophages in the stomach, duodenum, and colon. Intermediate blood monocytes were also increased in obesity, suggesting enhanced recruitment to the gut. We identified unhealthy lifestyle habits as potential triggers of gut and systemic inflammation (i.e., low vegetable intake, high processed meat consumption, sedentary lifestyle). Cardiovascular risk factors other than body weight did not affect the innate immune response. Thus, obesity in humans is characterized by gut inflammation as shown by accumulation of pro-inflammatory intestinal macrophages, potentially via recruited blood monocytes. Understanding gut innate immunity in human obesity might open up new targets for immune-modulatory treatments in metabolic disease., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2021 Rohm, Fuchs, Müller, Keller, Baumann, Bosch, Schneider, Labes, Langer, Pilz, Niess, Delko, Hruz and Cavelti-Weder.)- Published
- 2021
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36. The enemy of good is better, colonic obstruction post gastric bypass: an international video case series.
- Author
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Karthikeyan R, Takla H, Delko T, Badaoui JN, Kellog TA, and Ghanem OM
- Subjects
- Humans, Gastric Bypass adverse effects, Intestinal Obstruction etiology, Intestinal Obstruction surgery, Obesity, Morbid surgery
- Published
- 2021
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37. Long-Term Outcome of Proximal Versus Very-Very Long Limb Roux-en-Y Gastric Bypass: the Roux-Limb to Common Channel Ratio Determines the Long-Term Weight Loss.
- Author
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Süsstrunk J, Lazaridis II, Köstler T, Kraljević M, Delko T, and Zingg U
- Subjects
- Adult, Anastomosis, Roux-en-Y, Body Mass Index, Extremities, Female, Humans, Male, Middle Aged, Reoperation, Treatment Outcome, Weight Loss, Gastric Bypass, Laparoscopy, Obesity, Morbid surgery
- Abstract
Background: The influence of the Roux limb (RL) length on weight loss in Roux-en-Y (RYGB)-type gastric bypass procedures is still unclear. This study analyzes the true impact of RL length by comparing the long-term outcomes of proximal RYGB (PRYGB) and very-very long limb RYGB (VVLL-RYGB)., Methods: RL length in PRYGB was 150 cm. In VVLL-RYGB, common channel length was 100 cm. In both groups, biliopancreatic limbs measured 50-60 cm, resulting in equal total alimentary limb lengths. To adjust for pre-operative differences between groups, and to predict the long-term outcome, a mixed model analysis was performed., Results: Two hundred thirty-two patients with VVLL-RYGB (73.7% female, mean age 41.1 ± 10 years, initial BMI 45.8 ± 6.3 kg/m
2 ) and 223 with PRYGB (83.9% female, mean age 38.5 ± 11 years, initial BMI 42.9 ± 4.9 kg/m2 ) were included. Mean follow-up was 9.4 ± 4 years in VVLL-RYGB and 5.3 ± 1.9 years in PRYGB. After 5 years, mean BMI reduction was 15.7 ± 5.9 kg/m2 in VVLL-RYGB and 11.9 ± 4.1 kg/m2 in PRYGB (p < 0.001), and mean %EWL was 78.3 ± 23.1% and 70.2 ± 23.7% (p = 0.002) with a follow-up rate of 78% and 75.9%, respectively. The mixed model analysis showed a significantly higher weight rebound after PRYGB. Frequency of revisional surgery (i.e., limb length alteration, pouch banding) was similar between VVLL-RYGB and PRYGB (25 vs. 29 revisions, p = 0.463)., Conclusion: The VVLL-RYGB has a significantly higher long-term BMI reduction and a significantly lower weight rebound. The length of the Roux limb significantly influences long-term outcome.- Published
- 2021
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38. Mechanical colon obstruction due to the alimentary limb after Roux-en-Y gastric bypass: a case report.
- Author
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Peterson CJ, Klasen J, Delko T, and Schneider R
- Subjects
- Adult, Humans, Retrospective Studies, Young Adult, Gastric Bypass adverse effects, Intestinal Obstruction diagnostic imaging, Intestinal Obstruction etiology, Intestinal Obstruction surgery, Laparoscopy, Obesity, Morbid surgery
- Abstract
Background: Small bowel obstruction is a known and potentially lethal complication after gastric bypass surgery, in both the early and the late postoperative course. Colon or large bowel obstruction, on the other hand, seems to be rare after gastric bypass surgery and thus is not routinely considered., Case Presentation: We present the case of a 21-year old morbidly obese caucasian patient who underwent laparoscopic Roux-en-Y gastric bypass surgery and developed an early severe transverse colon obstruction due to compression of the transverse colon by the antecolic alimentary limb. Emergency revisional surgery showed a short and tense alimentary limb mesentery and possibly tight closure of Petersen's space contributing to the compression. Through opening of Petersen's space and mobilization of alimentary limb mesentery, decompression was achieved, and the patient fully recovered., Conclusions: This is a rare case of colon obstruction caused by direct compression of the transverse colon by the antecolic alimentary limb. We propose that a combination of short tense alimentary limb mesentery and perhaps tight closure of Petersen's space was responsible for the obstruction in this case. Surgeons and treating physicians need to be aware of such rare causes of early postoperative bowel obstruction and take these into consideration when evaluating patients.
- Published
- 2021
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39. Short or Long Biliopancreatic Limb Bypass as a Secondary Procedure After Failed Laparoscopic Sleeve Gastrectomy.
- Author
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Kraljević M, Süsstrunk J, Köstler T, Lazaridis II, Zingg U, and Delko T
- Subjects
- Gastrectomy, Humans, Reoperation, Retrospective Studies, Gastric Bypass adverse effects, Laparoscopy, Obesity, Morbid surgery
- Abstract
Purpose: Laparoscopic sleeve gastrectomy (SG) may be associated with long-term problems such as insufficient weight loss or weight regain, persistence or relapse of comorbidities, and gastroesophageal reflux disease (GERD). This study analyzes the outcome of patients that underwent conversion of SG to a gastric bypass procedure., Materials and Methods: All patients that underwent conversion from SG to the following four different gastric bypass procedures were analyzed: short biliopancreatic limb (BPL) bypass types such as proximal Roux-en-Y gastric bypass (PRYGB) or type 2 distal Roux-en-Y gastric bypass (type 2 DRYGB) and long BPL types such as long BPL RYGB or one anastomosis gastric bypass (OAGB)., Results: Between 2012 and 2016, 52 patients received the following revisional procedures after primary SG: proximal RYGB (n = 12, 23.1%), type 2 DRYGB (n = 8, 15.4%), long BPL RYGB (n = 20, 38.5%), and OAGB (n = 12, 23.1%). The long BPL type procedures (long BPL RYGB, OAGB) resulted in a significant long-term additional %EWL (33.8%; 33.2%) at 3 years. In the PRYGB, the effect lasted only for 2 years. In all patients with GERD and dysphagia as the dominant post-SG symptoms, the conversion to a bypass procedure resulted in the complete resolution of these., Conclusion: In case of weight regain or insufficient weight loss after SG, revisional surgery with a long BPL should be considered. The OAGB provides effective additional weight loss, with low morbidity and malnutrition rates, respectively. Conversion to the malabsorptive long BPL RYGB with a total alimentary limb length below 400 cm should be avoided. Patients that suffer primarily from post-SG GERD or dysphagia should undergo conversion to PRYGB.
- Published
- 2021
- Full Text
- View/download PDF
40. The Impact of the COVID-19 Pandemic on Bariatric Surgery: Results from a Worldwide Survey.
- Author
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Lazaridis II, Kraljević M, Schneider R, Klasen JM, Schizas D, Peterli R, Kow L, and Delko T
- Subjects
- Adult, COVID-19, Coronavirus Infections prevention & control, Coronavirus Infections transmission, Elective Surgical Procedures statistics & numerical data, Female, Humans, Male, Middle Aged, Pandemics prevention & control, Pneumonia, Viral prevention & control, Pneumonia, Viral transmission, SARS-CoV-2, Surveys and Questionnaires, Bariatric Surgery statistics & numerical data, Betacoronavirus, Coronavirus Infections epidemiology, Obesity, Morbid surgery, Pneumonia, Viral epidemiology, Practice Patterns, Physicians' statistics & numerical data
- Abstract
Background: The ongoing "coronavirus disease 19" (COVID-19) pandemic has had a strong effect on the delivery of surgical care worldwide. Elective surgeries have been canceled or delayed in order to reallocate resources to the treatment of COVID-19 patients. Currently, the impact of the COVID-19 pandemic on bariatric and metabolic surgical practice remains unclear., Methods: An internet-based online survey was performed among bariatric surgeons worldwide. The survey was sent to bariatric surgeons via the International Bariatric Club Facebook group and by electronic mail via the International Federation for the Surgery of Obesity and metabolic disorders (IFSO) secretariat to members of the associated national IFSO societies., Results: One hundred sixty-nine (n = 169) bariatric surgeons participated in the survey. The majority of the respondents postponed preoperative upper gastrointestinal tract endoscopies, appointments in the outpatient clinic and bariatric operations. Most surgeons performed video calls for follow-up appointments instead of meeting the patients in the outpatient clinics. Laparoscopy was still the preferred treatment for surgical emergencies, but a trend towards conservative treatment of acute appendicitis and acute cholecystitis was shown. Rapid preoperative COVID-19 testing availability was poor; therefore, routine screening of emergency bariatric cases was not widely provided. A wide variance occurred regarding precautions and personal protection equipment among the participants., Conclusion: The COVID-19 pandemic showed a strong impact on bariatric surgical practice regarding surgical and outpatient planning as well as personnel management. Coordinated effort from the national bariatric societies should focus on strict implementation of the current recommendations regarding precaution measures and personal protection equipment. Further studies should evaluate how this impact will evolve in the near future.
- Published
- 2020
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41. GLP-1 Analogues as a Complementary Therapy in Patients after Metabolic Surgery: a Systematic Review and Qualitative Synthesis.
- Author
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Schneider R, Kraljević M, Peterli R, Rohm TV, Klasen JM, Cavelti-Weder C, and Delko T
- Subjects
- Glucagon-Like Peptide 1, Humans, Randomized Controlled Trials as Topic, Bariatric Surgery, Complementary Therapies, Diabetes Mellitus, Type 2 drug therapy, Obesity, Morbid surgery
- Abstract
The evidence is strong that bariatric surgery is superior to medical treatment in terms of weight loss and comorbidities in patients with severe obesity. However, a considerable part of patients presents with unsatisfactory response in the long term. It remains unclear whether postoperative administration of glucagon-like peptide-1 analogues can promote additional benefits. Therefore, a systematic review of the current literature on the management of postoperative GLP-1 analogue usage after metabolic surgery was performed. From 4663 identified articles, 6 met the inclusion criteria, but only one was a randomized controlled trial. The papers reviewed revealed that GLP-1 analogues may have beneficial effects on additional weight loss and T2D remission postoperatively. Thus, the use of GLP-1 analogues in addition to surgery promises good results concerning weight loss and improvements of comorbidities and can be used in patients with unsatisfactory results after bariatric surgery.
- Published
- 2020
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42. Teaching in the operating room: A risk for surgical site infections?
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Mujagic E, Hoffmann H, Soysal S, Delko T, Mechera R, Coslovsky M, Zeindler J, Salm L, Marti WR, and Weber WP
- Subjects
- Clinical Competence, Europe epidemiology, Female, Humans, Male, Middle Aged, Operative Time, Prospective Studies, Risk Factors, Switzerland epidemiology, General Surgery education, Operating Rooms, Orthopedic Procedures education, Surgical Wound Infection epidemiology, Vascular Surgical Procedures education
- Abstract
Background/aim: To investigate whether teaching procedures and surgical experience are associated with surgical site infection (SSI) rates., Methods: This prospective cohort study of patients undergoing general, orthopedic trauma and vascular surgery procedures was done between 2012 and 2015 at two tertiary care hospitals in Switzerland/Europe., Results: Out of a total of 4560 patients/surgeries, 1403 (30.8%) were classified as teaching operations. The overall SSI rate was 5.1% (n = 233). Teaching operations (OR 0.78, 95% CI 0.57-1.07, p = 0.120), junior surgeons (OR 0.80, 95% CI 0.55-1.15, p = 0.229) and surgical experience (OR 0.997, 95% CI 0.982-1.012, p = 0.676) were overall not independently associated with the odds of SSI. However, for surgeons' seniority and experience, these associations depended on the duration of surgery., Conclusions: In procedures of shorter and medium duration, teaching procedures and junior as well as less experienced surgeons are not independently associated with increased odds of SSI., Competing Interests: Declaration of competing interest The authors have no conflicts of interest to disclose., (Copyright © 2020 Elsevier Inc. All rights reserved.)
- Published
- 2020
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43. Revisional Surgery for Insufficient Loss or Regain of Weight After Roux-en-Y Gastric Bypass: Biliopancreatic Limb Length Matters.
- Author
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Kraljević M, Köstler T, Süsstrunk J, Lazaridis II, Taheri A, Zingg U, and Delko T
- Subjects
- Adult, Biliopancreatic Diversion adverse effects, Body Mass Index, Duodenum surgery, Female, Follow-Up Studies, Gastric Bypass methods, Humans, Jejunum surgery, Laparoscopy methods, Malabsorption Syndromes epidemiology, Malabsorption Syndromes surgery, Male, Middle Aged, Obesity, Morbid epidemiology, Obesity, Morbid pathology, Organ Size physiology, Postoperative Complications epidemiology, Postoperative Complications etiology, Postoperative Complications surgery, Postoperative Period, Protein-Energy Malnutrition epidemiology, Protein-Energy Malnutrition surgery, Reoperation adverse effects, Switzerland epidemiology, Treatment Failure, Weight Gain physiology, Weight Loss, Biliopancreatic Diversion methods, Duodenum pathology, Gastric Bypass adverse effects, Jejunum pathology, Obesity, Morbid surgery, Reoperation methods
- Abstract
Introduction: Weight regain after laparoscopic Roux-en-Y gastric bypass (RYGB) occurs in up to 35% of patients. Revisional surgery may be applied. Conversion from RYGB to a long biliopancreatic limb (BPL) RYGB is a potential option for revisional surgery and short-term results are promising., Methods: All patients who underwent conversion to long BPL RYGB due to weight loss failure, defined as excess weight loss (EWL) < 50% or body mass index (BMI) > 35 kg/m
2 , were assessed. Proximal RYGB or very very long limb RYGB (VVLL RYGB) was modified by shortening of the total alimentary limb length (TALL) to create a long BPL., Results: A total of 28 patients received revisional surgery from either PRYGB (n = 22) or VVLL RYGB (n = 6). Mean age at operation was 45.3 ± 10.4 years, with 78% females. Mean prerevisional BMI was 41.7 ± 4.4 kg/m2 . Mean time to revision was 76.5 ± 38.5 months. Limb lengths were 150 cm (95% CI 133-156 cm) for RL and 100 cm (95% CI 97-113 cm) for CC, thus providing a total median alimentary limb length of 250 (95% CI 238-260 cm). Additional %EWL and TWL improved significantly in long-term. Five years postoperatively, all patients (n = 9) had an EWL% > 50%. Six patients (21.4%) required reoperation due to severe malnutrition during the postoperative course., Conclusion: Conversion from RYGB to BPL RYGB leads to significant additional weight loss in the long term. However, the morbidity is relevant, especially severe protein malnutrition and the frequency of revisional surgery. Therefore, this type of surgery should not be done routinely.- Published
- 2020
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44. Tumor Infiltration by OX40+ Cells Enhances the Prognostic Significance of CD16+ Cell Infiltration in Colorectal Cancer.
- Author
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Haak F, Obrecht I, Tosti N, Weixler B, Mechera R, Däster S, von Strauss M, Delko T, Spagnoli GC, Terracciano L, Sconocchia G, von Flüe M, Kraljević M, and Droeser RA
- Subjects
- Adult, Aged, Aged, 80 and over, Colorectal Neoplasms pathology, Female, Humans, Male, Middle Aged, Prognosis, Tissue Array Analysis, Colorectal Neoplasms genetics, OX40 Ligand metabolism, Receptors, IgG metabolism
- Abstract
Objectives: Analysis of tumor immune infiltration has been suggested to outperform tumor, node, metastasis staging in predicting clinical course of colorectal cancer (CRC). Infiltration by cells expressing OX40, a member of the tumor necrosis factor receptor family, or CD16, expressed by natural killer cells, monocytes, and dendritic cells, has been associated with favorable prognosis in patients with CRC. We hypothesized that assessment of CRC infiltration by both OX40+ and CD16+ cells might result in enhanced prognostic significance., Methods: Colorectal cancer infiltration by OX40 and CD16 expressing cells was investigated in 441 primary CRCs using tissue microarrays and specific antibodies, by immunohistochemistry. Patients' survival was evaluated by Kaplan-Meier and log-rank tests. Multivariate Cox regression analysis, hazard ratios, and 95% confidence intervals were also used to evaluate prognostic significance of OX40+ and CD16+ cell infiltration., Results: Colorectal cancer infiltration by OX40+ and CD16+ cells was subclassified into 4 groups with high or low infiltration levels in all possible combinations. High levels of infiltration by both OX40+ and CD16+ cells were associated with lower pT stage, absence of peritumoral lymphocytic (PTL) inflammation, and a positive prognostic impact. Patients bearing tumors with high infiltration by CD16+ and OX40+ cells were also characterized by significantly longer overall survival, as compared with the other groups. These results were confirmed by analyzing an independent validation cohort., Conclusions: Combined infiltration by OX40+ and CD16+ immune cells is an independent favorable prognostic marker in CRC. The prognostic value of CD16+ immune cell infiltration is significantly improved by the combined analysis with OX40+ cell infiltration.
- Published
- 2020
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45. [New endoluminal and surgical methods for the treatment of morbid obesity].
- Author
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Delko T
- Subjects
- Humans, Laparoscopy, Postoperative Complications, Switzerland, Endoscopy, Gastrointestinal instrumentation, Endoscopy, Gastrointestinal methods, Gastric Bypass instrumentation, Gastric Bypass methods, Obesity, Morbid surgery
- Abstract
New endoluminal and surgical methods for the treatment of morbid obesity Abstract. A number of endoluminal techniques to treat (morbid) obesity have been developed recently aiming at finding less invasive methods that may be more acceptable for patients. Through upper endoscopy changes are made to the gastro-intestinal tract. Welldesigned trials have to prove their effectiveness and safety. In the meantime they remain experimental and this has to be communicated to the patient. New operative techniques have also been developed. The One Anastomosis Gastric Bypass is a variation of the standard Roux-Y-Gastric Bypass. There is evidence supporting that it can also become an accepted standard bariatric procedure in Switzerland.
- Published
- 2019
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- View/download PDF
46. Influence of Asian Ethnicities on Short- and Mid-term Outcomes Following Laparoscopic Sleeve Gastrectomy.
- Author
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Koh ZJ, Tai BC, Kow L, Toouli J, Lakdawala M, Delko T, Kraljević M, Huang CK, Raj P, Cheng A, Rao J, Eng A, Kosai NR, Rajan R, Kim GW, Han SM, So JBY, Kasama K, Lee WJ, Kim YJ, Wong SKH, Ikramuddin S, and Shabbir A
- Subjects
- Adult, Asia epidemiology, Ethnicity, Female, Gastrectomy, Humans, Laparoscopy, Male, Obesity, Morbid ethnology, Obesity, Morbid surgery, Retrospective Studies, White People, Asian People classification, Obesity, Morbid epidemiology, Weight Loss
- Abstract
Purpose: Prevalence of obesity in Asia has been on the increasing trend, with corresponding increase in utilisation of bariatric surgery. The objective of this study was to examine differences in weight loss outcomes following bariatric surgery between Asian ethnicities., Materials and Methods: A retrospective database review was conducted of patients undergoing primary laparoscopic sleeve gastrectomy between 2009 and 2013 in 14 centres from Singapore, Malaysia, Taiwan, Hong Kong, Japan, Korea, India, Australia, Switzerland, and the USA. All patients with available follow-up data at 12 months and 36 months post-surgery were included in this study. Outcome measures used were percentage excess weight loss (%EWL) and percentage total weight loss (%TWL). Differences in outcomes between ethnicities were analysed after adjusting for age, gender, baseline body mass index (BMI), and presence of diabetes., Results: The study population (n = 2150) consisted of 1122 Chinese, 187 Malays, 309 Indians, 67 Japanese, 259 Koreans, and 206 Caucasians. 67.1% were female and 32.9% were male. Mean age was 37.1 ± 11.2 years. Mean pre-operative BMI was 40.7 ± 8.1 kg/m
2 . With the Caucasian population as reference, Japanese had the best %TWL (3.90, 95% CI 1.16-6.63, p < 0.05) and %EWL (18.55, 95% CI 10.33-26.77, p < 0.05) while the Malays had the worst outcomes. Both Chinese and Koreans had better %EWL but worse %TWL as compared to Caucasians and there were no significant differences with the Indian study group., Conclusion: There are differences in weight loss outcomes following bariatric surgery between Asian ethnicities.- Published
- 2019
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47. Surgical repair of an esophageal perforation after radiofrequency catheter ablation for atrial fibrillation.
- Author
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Badertscher P, Delko T, Oertli D, Reuthebuch O, Schurr U, Pradella M, Kühne M, Sticherling C, and Osswald S
- Abstract
Recent reports have described the incidence of atrioesophageal fistulas (AEF), often resulting in death, from radiofrequency (RF) catheter ablation of atrial fibrillation (AF).
1 Cases of esophageal perforation without concomitant AEF have not been described as extensively.1 The precise mechanisms leading to esophageal injury after catheter ablation without involvement of the left atrium are not fully understood. The surgical approach to treat esophageal perforation is strongly recommended.2 However, a unified surgical treatment approach has not yet been established. We describe a case of successful surgical repair of an esophageal perforation after ablation using surgical repair in combination with an omental wrap., (Copyright © 2019 Indian Heart Rhythm Society. Production and hosting by Elsevier B.V. All rights reserved.)- Published
- 2019
- Full Text
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48. The association of surgical drains with surgical site infections - A prospective observational study.
- Author
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Mujagic E, Zeindler J, Coslovsky M, Hoffmann H, Soysal SD, Mechera R, von Strauss M, Delko T, Saxer F, Glaab R, Kraus R, Mueller A, Curti G, Gurke L, Jakob M, Marti WR, and Weber WP
- Subjects
- Adult, Aged, Drainage adverse effects, Female, Humans, Logistic Models, Male, Middle Aged, Odds Ratio, Operative Time, Prospective Studies, Risk Factors, Switzerland, Drainage statistics & numerical data, Surgical Wound Infection epidemiology
- Abstract
Background: Surgical drains are widely used despite limited evidence in their favor. This study describes the associations between drains and surgical site infections (SSI)., Methods: This prospective observational double center study was performed in Switzerland between February 2013 and August 2015., Results: The odds of SSI in the presence of drains were increased in general (OR 2.41, 95%CI 1.32-4.30, p = 0.004), but less in vascular and not in orthopedic trauma surgery. In addition to the surgical division, the association between drains and SSI depended significantly on the duration of surgery (p = 0.01) and wound class (p = 0.034). Furthermore, the duration of drainage (OR 1.24, 95%CI 1.15-1.35, p < 0.001), the number (OR 1.74, 95%CI 1.09-2.74, p = 0.019) and type of drains (open versus closed: OR 3.68, 95%CI 1.88, 6.89, p < 0.001) as well as their location (overall p = 0.002) were significantly associated with SSI., Conclusions: The general use of drains is discouraged. However, drains may be beneficial in specific surgical procedures., (Copyright © 2018 Elsevier Inc. All rights reserved.)
- Published
- 2019
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49. Boosted darunavir, emtricitabine and tenofovir pharmacokinetics in sthe early and late postgastric bypass surgery periods.
- Author
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Baettig V, Courlet P, Delko T, Battegay M, and Marzolini C
- Subjects
- Administration, Oral, Adult, Anti-HIV Agents administration & dosage, Bariatric Surgery, Chromatography, Liquid, Darunavir administration & dosage, Emtricitabine administration & dosage, Female, HIV Infections complications, HIV Infections drug therapy, Humans, Obesity complications, Obesity surgery, Plasma chemistry, Tandem Mass Spectrometry, Tenofovir administration & dosage, Anti-HIV Agents pharmacokinetics, Darunavir pharmacokinetics, Emtricitabine pharmacokinetics, Gastric Bypass, Tenofovir pharmacokinetics
- Published
- 2018
- Full Text
- View/download PDF
50. High OX40 expression in recurrent ovarian carcinoma is indicative for response to repeated chemotherapy.
- Author
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Ramser M, Eichelberger S, Däster S, Weixler B, Kraljević M, Mechera R, Tampakis A, Delko T, Güth U, Stadlmann S, Terracciano L, Droeser RA, and Singer G
- Subjects
- Adult, Aged, Carcinoma genetics, Carcinoma pathology, Disease-Free Survival, Drug Therapy, Drug-Related Side Effects and Adverse Reactions genetics, Female, Gene Expression Regulation, Neoplastic, Humans, Middle Aged, Neoplasm Staging, Ovarian Neoplasms genetics, Ovarian Neoplasms pathology, Prognosis, Biomarkers, Tumor genetics, Carcinoma drug therapy, OX40 Ligand genetics, Ovarian Neoplasms drug therapy
- Abstract
Background: Ovarian carcinoma (OC) is the fifth most common female cancer and mostly diagnosed at an advanced stage. Surgical debulking is usually followed by adjuvant platinum-based chemotherapy. Only few biomarkers are known to be related to chemosensitivity. OX40 is a TNF receptor member and expressed on activated CD4+ and CD8+ T cells. It is known that OX40 signaling promotes survival and responds to various immune cells of the innate and adaptive immune system. Therefore we investigated the indicative value of OX40 expression for recurrence and survival in OC., Methods: A tissue microarray of biopsies of mostly high-grade primary serous OC and matched recurrences of 47 patients was stained with OX40. Recurrence within 6 months of the completion of platinum-based chemotherapy was defined as chemoresistance., Results: Chemosensitivity correlated significantly with high OX40 positive immune cell density in primary cancer biopsies (p = 0.027). Furthermore patients with a higher OX40 expression in recurrent cancer biopsies showed a better outcome in recurrence free survival (RFS) (p = 0.017) and high OX40 expression was associated with chemosensitivity (p = 0.008). OX40 positive TICI in recurrent carcinomas significantly correlated with IL-17 positive tumor infiltrating immune cells in primary carcinomas (r
s = 0.34; p = 0.023). Univariate cox regression analysis revealed a significant longer RFS and higher numbers of chemotherapy cycles for high OX40 tumor cell expression in recurrent cancer biopsies (HR 0.39, 95%CI 0.16-0.94, p = 0.036 and 1.28, 95%CI 1.05-1.55; p = 0.013)., Conclusion: High OX40 expression in OC is correlated with chemosensitivity and improved RFS in OC. Patients might therefore benefit from a second line therapy.- Published
- 2018
- Full Text
- View/download PDF
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