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Volcanic ash is danger for aviation because it harms the flight engine. This study presented the simulation of volcanic ash dispersion with the PUFF-Langarangian methods. The data was conducted from the Tangkuban Perahu volcano, which was erupted on 26 July 2019 in West Java, Indonesia. The results simulated volcanic ash dispersion based on the ash concentration and altitude at 105 minutes after the eruption. Simulation results were then compared with the satellite image of volcanic ash dispersion from The Indonesian Meteorological, Climatological, And Geophysical Agency or BMKG. With correction factor −14.75°, then the α = 0.50717°, AR = 0.99138, the simulation was fit with the satellite image. The simulation results showed that the combination of PUFF and Lagrangian methods gave a better volcanic ash dispersion map. [ABSTRACT FROM AUTHOR]

A digital image is used in every field, i.e., security, medical, entertainment, and many more. To save time and space the image was transmitting and storage through internet. There is a need for security guaranty during the image's transmission and storage, therefore the data secure and authentic. This study was conducted to protect the digital image during transmission and storage by encrypted it with a secure image protection algorithm based on the chaotic logistic map. The results compared the histograms of plain image, permutated image, chipper image, decoded image, and plain image. The histogram of the encrypted image is uniform, which means the image pixels were distributed uniformly. Therefore, plain and encrypted images were totally different. It was also shown by the correlation coefficient of the encrypted image; it was 0.0269, which closed to 0. [ABSTRACT FROM AUTHOR]

Humankind throughout the world are currently in a state of collapse due to the outbreak of Corona Virus Disease (COVID-19) which began in Wuhan, China. Later on, it was announced as the pandemic situation according to WHO. Overall countries have implemented social distancing, while Indonesia has implemented a policy of learning from home, working from home, and worship at home or better known as work from home (WFH). This study aimed to determine the level of readiness to implement e-learning during WFH due to the pandemic COVID-19 spreads along with the challenges in the 4.0 revolution in millennials. The model that used was the Aydin & Tasci model which measures four main factors namely technology, innovation, people, and self-development. Data collection was conducted online using Google Form, while data processing uses a descriptive statistical method mapped based on the Aydin & Tasci version of the e-learning readiness index. The results showed that the overall e-learning readiness index might indicate that the system was ready to be implemented, but required a slight increase in several factors, namely innovation increase, human, and self-development factors. The results and discussion of the study showed the readiness of e-learning to follow the demands of Revolution 4.0, even though it was done during WFH because of the COVID-19 pandemic outbreak. [ABSTRACT FROM AUTHOR]

I Gusti Ngurah Rai International Airport is a public service company that must pay attention to customer satisfaction. Therefore, A Strategic Business Unit has to manages the customer satisfaction system. However, this unit only has a system that can be use to input and display satisfaction and complaints from customers. The development of customer satisfaction system needs to be applied by applying the dimensions of the SERVQUAL method which is expected to facilitate PT. Angkasa Pura I (Persero) improves service quality. The waterfall method is used in research for the development of the system, while the structured method is used to analyze and design the system. The results show that the five dimensions of service satisfaction are in the quite satisfied range. The score is in the range of 2-3. The score implication shows that I Gusti Ngurah Rai airport service quality is quite satisfying for consumers. [ABSTRACT FROM AUTHOR]

One of the uses of the Chinese Remainder Theorem (CRT) is to shorten the time in the RSA Cryptosystem decryption process. However, in applying a combination of the CRT method and the RSA Algorithm with Python programming modules, recursion errors often occurred when determining the inverse modulus to establish the private key. The error was caused by limitation iterations of the related algorithm. Some Python library needs more iteration processes to calculate the inverse modulus for larger key size. This is a pure computational problem. The standard RSA algorithm uses two prime numbers to generate their key pairs. The multi-prime RSA modification based on more than two prime numbers can be applied to solve the problem. A modified RSA was applied in Python programming that generates keys based on 2, 4, 8, 16, and 32 prime numbers. Regarding on our experiments, the combination of the CRT method and RSA algorithm based on four prime numbers can be applied without recursion error up to a key length of 6280 bits, with eight primes up to 12,560 bits, with sixteen primes up to 25,120 bits, and with thirty-two primes up to 50,240 bits. Implementation of more multi-prime numbers can expand to combine the CRT method and RSA Algorithm for longer key sizes by approximation relation y = 1567,8x + 63,333, which y is the key size and x is the number of primes numbers. The method also can increase key generation and decryption rate significantly. [ABSTRACT FROM AUTHOR]

The role of Information Technology (IT) in the digital era today is critical in the business environment. IT will provide convenience in the process of managing a Small and Medium Enterprises (SMEs) so that companies have a competitive advantage in the current economic development. Some research has been discussed the issue of IT adoption's impacts and uses in SMEs, in particular in the suburbs bordering the national capital. The purpose of this study is to identify the impact of IT and the factors that influence technology readiness in IT adoption the organizational context among SMEs located in the suburbs of Jakarta. This article follows a quantitative research approach based on case studies and structured questionnaires. The results of SEM analysis using the SmartPLS3 application give the results that awareness of technology, local government support, SME management support, and financial support are essential factors in IT adoption in SMEs. This article tries to look at other phenomena regarding the limitations SMEs have in using IT and tries to make a recommendation on how to overcome them. It is hoped that this research will contribute to the development of information systems models both in terms of academics and practitioner. [ABSTRACT FROM AUTHOR]

The aim of this study is to implement Fisher-Yates Shuffle Algorithm (FYSA) for randomization Math Exam in Computer Based-Test with fast execution time and can be generated without repetition and duplication. This study case in Management and Science University (MSU) Malaysia. This study used ADDIE model and develop based on a website framework using PHP as a back-end programming language, Java script as a client-side programming language, and MySQL as a database. The target population of this study was students in Bachelor Level at Management and Science University (MSU) Malaysia in Mathematics Subject. The subject will be focused on probability and statistics in one focus group. Mathematics lecturer also involved as expert in this study. There are seven questions set with a total questions N=15 on each set. The probability value of randomization the question set is 1/7 = 0.14285714. The permutation obtained from the randomization of Fisher Yates Shuffle is 15! = 1.307674368 x 1012. Based on the results of the quality test, it can be seen that all items of category regarding accessibility, helpful tools, and CBT content have an average percentage score 76.94%, these results mean that all CBT items are works well. That means the system will produce different random permutations each time students take question. [ABSTRACT FROM AUTHOR]

The convenience, speed, accuracy, security are the four main indicators of information quality that are concerning for people to be able access information in a public institution dashboard system. To find out whether the data displayed on the system is easily understood by the users, an empirical evaluation study might be indispensable to be performed. Evaluating user experience is one way to know whether a system is in accordance with user needs or not, whether related to data, interfaces, or system performance. This study assessed user experiences based on the product pyramid and its development process in the case of a public dashboard system in a public institution in Indonesia. The empirical experiment was conducted by 15 participants used a scenario that was deliberately designed and then gave answers to the single ease question (SEQ) and the system usability scale (SUS). The results show that SEQ measurement obtained almost 5.7 amount of score which indicates the application measurement results reach an easy level. The SUS results demonstrated that the system was in the acceptable category with a score around 81.3 Although the findings of the study might not contribute theoretically, it may demonstrate a practical consideration for the stakeholders, in terms of the next system development stage. [ABSTRACT FROM AUTHOR]

Aquaponic Cultivation Technology can be done inside the house or outside the home, this cultivation also produces plants and fish that can be used by the community with urban farming on local food. Aquaponic system fish farming is a culture system that can save land use and increase the efficiency of nutrient utilization from the rest of the feed and fish metabolism. The purpose is to design water temperature sensors on aeroponics and to test temperature sensors by validating others.. The design of an early warning system application due to a landslide there are several stages, namely: first, Designing a DS18B20 sensor on acuponics. Second, Testing the DS18B20. The measurement results will be stored on the scratchpad and read by the device. This sensor can measure temperatures in the range 0 ° -50 ℃. Microcontroller functions as an electronic circuit controller and stores the program in it. Microcontroller is called a single chip because the microcontroller has a memory and I / O devices. The test was carried out using a container containing chunks of ice. The test was carried out safely for 15 minutes and data was taken every minute. Testing the DS18B20 sensor with a comparison sensor found an average error of 0.0409 with a standard deviation of 0.08023. The results of the measurement of small error errors presented that the DS18B20 sensor can be used properly. [ABSTRACT FROM AUTHOR]

In this study, the performance of magnetite-montmorilonite composites in absorbing Co2+ and Cd2+ composites made from Pacitan bentonite and natural iron ore reported. Composites are synthesised by inserting iron oxide into the interlayer of bentonite and then calcined at 400 °C for 1 hour. magnetite formed in the interlayer gallery of bentonite has a magnetite structure and high thermal stability. The adsorption of Co2+ and Cd2+ cations was carried out in aqueous solution by batch method at various initial pH variations, contact time, and initial concentration of the solution. The results showed that the two metal cations were absorbed maximum at pH 5 in contact time of 10 minutes for Co2+ and 105 minutes. The maximum concentration of Co2+ that can be absorbed occurs at 50 ppm and 70 ppm for Cd2+. Adsorption of the two cations follows the Langmuir adsorption isotherm pattern with an R2 of 0.945 for Co2+ and 0.995 for Cd2+. The adsorption energy of Co2+ adsorption is -23.42 kJ / mol and -32.45 kJ / mol for Cd2+. [ABSTRACT FROM AUTHOR]

Quality of website design is one of the influential factors of website success. How the design helps the users using the website effectively and efficiently and satisfied at the end of the use. However, it is a common tendency that websites are designed based on the developer's perspectives and less consideration on the user's importance. Thus, the degree of website usability tends to be low, according to user perceptions. This study purposed to understand the user experiences using an institutional repository (IR) website in a public university in Indonesia. The research was performed based on usability testing framework as the usability testing method. About 12 participants were purposely involved regarding their key informant characteristics. Following three empirical data collection techniques (i.e., query technique, formal experiment, and thinking aloud), both descriptive analysis using usability scale matric and content analysis using qualitative data analysis (QDA) Miner Lite software were used in the data analysis stage. Lastly, several visual design recommendations were then proposed at the end of the study. In terms of a case study, besides the practical recommendations which may contextually useful for the next website development, the clarity of the research design may also help scholars how to combine more than one usability testing techniques within a multi-technique study design. [ABSTRACT FROM AUTHOR]

It is undeniable that people life patterns and technological developments are interrelated within a supply and demand cycle. In the education world, the emergence of the internet and mobile technologies has opened the learning boundaries through the use of mobile learning (m-learning). In Indonesia, the learning service industry has been begun to enliven the outside school education sector for almost five years ago. Even though the learning has been discussed around a decade ago, however, it is still rare studies that discuss the performance of the m-learning system based on the end-user perceptions in particular. Therefore, the study may still indispensable, especially from the perspectives of a developing nation. This paper elucidates the preliminary stage results of the above-mentioned study, including the results of the model development and its instrument testing. The DeLone and Mclean's information system (IS) success model was adopted, combined with the individual motivation and organizational culture theories, and then adapted into the processional and causal logic of the success model. Around 50 respondent data were collected online and processed and analyzed based on the outer model assessments of the PLS-SEM method using SmartPLS 3.0 to know the reliability and validity of each indicator. The result shows that two of 31 are rejected indicators. The rejections may be the revision considerations for the next study stages. Although this may be trivial for experts, the clarity of its methodological explanations may guide the novice researchers, how to develop a research model and its instrument testing. [ABSTRACT FROM AUTHOR]

The teacher needs to know the learner's progress so that he/she can improve her/his teaching strategy. The initial challenges faced by the teachers are including the need to monitor each learner's progress so that their needs and difficulties can be recognized as a guide for enhancing learning strategies. One way to solve these problems is to predict student's progress. Mathematics in elementary school is one of the subjects with a high failure rate of learners. In this study, the progress of learners was predicted using Random Forest based on classification using similarity characteristics of learners obtained from the results of previous formative assessment. The random forest algorithm was used because it can classify data that has incomplete attributes, which are usually contained in learner characteristics. Prediction models are built based on data of assessment results from 2 math classes with 46 students in elementary school. The resulting model performance will be measured using accuracy and recall because False Positive is better than False Negative so learning progress will always be improved. The results show that the Random Forest algorithm can create a learning progress prediction model with an accuracy of 90% in training data and 93% in testing data. [ABSTRACT FROM AUTHOR]

Laboratory materials testing courses often result in errors in the process leading to incorrect results. Making video tutorials aims to improve students' skills in practical laboratory material test subjects. This paper uses a research and development model from Thiagarajan. The 4D steps are to Define, Design, Development, and Dissemination. The resulting video tutorial consists of 12 video materials adjusted to the basic competencies in the practical material test. Media validation had carried out with a feasibility value of 91.54. From material experts 95.5 and the assessment of 12 video tutorials by students with an average score of 80.56. Based on the results of the study, it shows that the tutorial media containing 12 materials is very suitable for use in the material test practicum subject. [ABSTRACT FROM AUTHOR]

The use of instructional video on learning outcomes in the learning of statistics under COVID-19 Pandemic is very important. The purpose of this study is to examine the impact of instructional videos on learning performance. We have conducted a quasi-experiment involving 80 students, in which 30 students were placed in a group and given instructional, work-example video with attention-focusing guidance + analog assignment, 21 students placed in a group and given a work-example video without attention-focusing guidance + analog assignment, and the remaining 29 students were given work example video with attention-focusing guidance + incomplete assignment. Five of the question-based cases were used to measure the impact of the instructional video on learning performance. The work-example video was given through Google Classroom to deliver the contents to groups. Based on ANCOVA, we would conclude that none of the three methods is effective or equally effective to control the effects of ability and interest to math. Note that this outcome is different from what we have obtained in our original ANOVA; without taking math ability and interest into account, the three teaching methods were more effective than the others. [ABSTRACT FROM AUTHOR]

This study aims to analyze the effect of mobile learning media and scientific reasoning ability on students' creative thinking on chemistry bonding material. This research was carried out in a state high school in Jakarta, Indonesia. The test is carried out during the first semester of the 2019/2020 school year. The research method implemented in the study is a quasi-experiment with treatment design by level 2x2, then the data acquired are analyzed with two-way ANOVA. The research sample consists of 40 science students in grade 10, and then the sample is divided into two categorized, namely the experiment class of 20 students and the control class of 20 students. They are selected by a multi-stage random sampling technique. In the experiment class, the learning process used mobile learning media while in the control class, the learning process used traditional or conventional media. Scientific reasoning tests and creative thinking tests are the test instruments used in this research. The result shows that students who learn through mobile learning have higher creative thinking skills than those who learn through traditional media. The result also shows that there is an effect of mobile learning media interaction and scientific reasoning ability on students' creative thinking. The use of mobile learning media has positive impacts on students' creative thinking for students who have high scientific reasoning. On the other hand, it has negative impacts on students' creative thinking for students who have lower scientific reasoning. [ABSTRACT FROM AUTHOR]

The concept of 21st-century education in the era of the industrial revolution 4.0 demands optimal digitalization and computerization innovation. The utilization of technology makes the learning process take place continuously without space and time limits. This study aims to produce electronic-modules (e-modules) as instructional materials for protein structure and function using the Flip PDF Professional application. The method that used refers to the research and development of the Borg and Gall model with a questionnaire research instrument. The research and the development procedures are preliminary study, research planning, initial product development, small scale field test, revision of small scale field test results, large scale field test, and revision of large field test results The electronic module consists of an introduction and discussion of the material (based on the learning design of the Biomolecular Protein Structure and Function course in Chemistry Education undergraduate courses). Besides, the e-module is equipped with videos, images, animations, links to various main sources, and formative tests on each protein structure and function material. Product validation is done based on the material, language, and media experts using standard instruments with a Likert scale. The results of the three experts' validation of the developed e-modules showed good great interpretations. Based on the results of the validation, it can be concluded that the electronic module structure and function of proteins are ready to use as learning media. [ABSTRACT FROM AUTHOR]

Pyrazoline analogues have been reported with some significant biological activities, such as anticancer, antidiabetic and antimalarial. In this work, a fluorinated pyrazoline analogue, 5-(4-fluorophenyl)-3-(naphthalen-1-yl)-4,5-dihydro-1H-pyrazole (Compound 3) has been synthesized under microwave irradiation. The structure of synthesized compound was confirmed based on the spectroscopic data i.e. UV, FT-IR, GCMS, and 1H NMR. Based on the in silico study, the synthesized compound possessed a potent inhibitory activity against human thymidilate synthase (hTS) (PDB ID 4E28). The docking results of the pyrazoline analogue to this enzyme showed the binding free energy of -4.4397 kcal/mol and it is lower than 5-fluorouracil (5-FU) used as reference for anticancer drug (-2.2774 kcal/mol). In addition, the result of in vitro cytotoxic evaluation showed that the synthesized compound exhibited a strong cytotoxic activity against HeLa cell line with IC50 value of 27.56 µg/ml. The result of both in silico and in vitro evaluations suggests that the compound 3 might be a promising agent for cervical cancer treatment. [ABSTRACT FROM AUTHOR]

Electrodeposited Nickel (Ni)-/Nitride composite coating has been widely used and studied in many technological applications due to its high resistance to wear and corrosion. The morphology and composition of the composite coating were key for the remarkably performance and could be obtained during the deposition process. This paper is a report on a preliminary study of the effect of elevated temperature at 50 °C and 60 °C on the microstructure of Ni-TiN-AlN/Si3N4 composite coatings. The deposition process was conducted by using electrodeposition at a fixed current density of 2.5 mA/cm2 for 15 minutes. The bath composition consisted of 6 g/L TiN, 6 g/L AlN, 0.6 g/L Si3N4, 0.17 M NiCl2(6H2O), 0.38 M NiSO4(6H2O), 40 g/L H3BO3, and 0.6 g/L SDS. The surface morphology and composition are characterized by using Scanning Electron Microscopy (SEM) and Energy Dispersive Spectroscopy (EDS), respectively. It shows that the coating morphology was more compact at a temperature of 60 °C, followed by the decrease of Ni content while Ti, Al, and Si contents increased. [ABSTRACT FROM AUTHOR]

Flipped teaching does a reversal of the traditional instructional delivery in the classroom. Some students in the classroom play passive roles in the learning process and make it quite boring for the student and reduce engagement. In this study, students in a technical university participate in finding out their perception of taking a course using the flipped classroom model, identifying the benefits and challenges encountered, and suggestions to improve further implementations. The students were involved in the implementation of a flipped classroom technique in the study of the course by participating in pre-class activities and in-class activities. The students worked in groups to enhance teamwork and collaboration and also took part in presentations and demonstrations. At the end of the sessions, there was student evaluation and peer facilitator evaluation. 16.6% of the students gave a Fair rating to the sessions. 46.7% rated the sessions to be Good, while 36.7% of the students gave a Very Good rating to the flipped classroom sessions. The students gave a high rating of the constructs used in the questionnaire (motivation, effectiveness, engagement, and overall satisfaction) based on the mean scores. Some challenges were encountered during the study. Nevertheless, there was a conclusion that the flipped classroom teaching technique encouraged self-learning and learner engagement and transformed the class with student-centered activities. However, the study recommended proper preparation and planning of pre-class and in-class activities from the facilitator when implementing a flipped classroom session. [ABSTRACT FROM AUTHOR]

This study aims to design an application model in the field of health at the Indonesian Ministry of Health using the administration of a database of health insurance participants in the 2019 COBIT framework. The International ISO issues ISO / IEC 27002 where there is a list of generally accepted control objectives and best practice controls that can be used as implementation guidelines when selecting and implementing controls to achieve information security in the field of health services as follows: To design the context design of the which is a health application that uses the COBIT and OECD framework, To support the implementation of the principles of transparency and accountability in the context of RKAPB based on cloud computing and IoT in public health center and hospitals throughout Indonesia and To produce the IPR context of the Indonesian National standards Application that can be used by national Ministry of Health agencies and other private Health Industries. The object of the study is the data of participants in the health insurance of the province of Jakarta, Indonesia. The research instrument uses the 2019 COBIT Framework and the 2019 OECD Health Statistics for standardization based on Indonesian National standards, which is the database of health insurance participants of the Indonesian Ministry of Health and the 2018 OECD Statistics administration database as objects. The sampling technique is to use the ISS application prototype. The results of the study are the design of application models in the health sector at the Indonesian Ministry of Health which are standardized based on Indonesian National standards. [ABSTRACT FROM AUTHOR]

The coronavirus pandemic brought the world together in dealing with it. Knowledge about Coronavirus requires academics and scientists to be able to provide as much information about Coronavirus as possible, like how to handle it and how to identify the signs of people affected by the virus. The formulation of the research problem is to find out the elaboration of natural science with information technology during the 2020 coronavirus pandemic. The purpose of this study is to analyze the elaboration of information technology in the 2020 coronavirus pandemic. This research is supported by previous researches. Information technology is a new technology in transferring information both from academics and from social knowledge about certain phenomena. Therefore, this information can be useful for the community. This quantitative study is spread to respondents in regions in Indonesia. Data was added by in-depth interviews and data searching through electronic media. The reflection of the research is a dimension of information technology and science with positive ideas. Further regression analysis shows the effect of information technology on vast knowledge regarding the Coronavirus and changes in people's attitudes. The public began to comply with the distribution of information about the characteristics of Coronavirus, its prevention, understand the symptoms of contracting the virus, and obey the advice of doctors to anticipate from being infected by the virus. This research recommends how to deal with this pandemic so that the results of the research can benefit the community. [ABSTRACT FROM AUTHOR]

Coronavirus makes the world community unite in providing health education, providing information on data affected and recovering from the Coronavirus pandemic. The formulation of the research problem is how the interaction of education and social science in digital regarding the handling of this Coronavirus pandemic. Previous research strongly supports this research. Digital media is a medium that can inform, such as mainstream media. With the sophistication of information technology, information about the Coronavirus pandemic can be known and change the habits of human life in the world. This research is a questionnaire on observational observation through in-depth interviews and many information technologies are optimized. Knowledge education about the Coronavirus pandemic provides a lot of knowledge until the changes in human life today. From knowledge structures to myths and religious perspectives are included in the spread of handling this Coronavirus pandemic. The interactions that occur between science and social science are of good value in today's society. Science provides human habits for proper hand washing, Coronavirus indications, signs of being exposed to the Coronavirus, and its handling and community interactions that have been heeded. For example, sneezing carelessly, sick conditions, not using a mask, touching, and so on, these habits are lost. The research suggestion is the existence of a scientific and social science perspective in handling various current conditions. [ABSTRACT FROM AUTHOR]

This research aims to review systematically and analyze the results of research regarding the use of microcontrollers for the Internet of Things (IoT). This literature review is aimed specifically to find out the use of microcontroller technology of IoT for the health sector. The microcontroller system being studied is specific using the Arduino board. The research method uses a systematic review with 4 (four) stages of work: identification, screening, eligibility, and input. Search articles using three databases: IEEE Xplore, IOP and SpringerLink during these past five years (2015-2019). The articles are should based on international proceedings and journals in English that accessed by full text. The result of study found that 859 research articles have discussed the use of the microcontroller to the IoT. Most of the articles published in international proceedings and the researches are from developed countries. The Arduino board uses the Arduino uno model and the temperature type of sensors, humidity sensors, gas sensors, smoke sensors, camera sensors, light sensors, and motion sensors. Microcontroller systems for IoT can be used in various fields such as house construction, industry, transportation, agriculture, sports, health, and the environment. The application of microcontroller technology to IoT in the field of health is to monitor patient health condition. For example: monitoring the patient's heart rate, hearing aid technology, navigation assistance for the visually impaired, smart home for disabled people, and smart box for medicine. [ABSTRACT FROM AUTHOR]

The weak of the security system in the bicycle parking lot causes a high rate of bicycle thievery. This study aims to improve the security system in a bicycle parking lot. Using research and development methods from existing studies, we create a bicycle parking security system by locking the bicycle tires if the bicycle owner has registered his fingerprint. This safety system uses a microcontroller (Arduino Mega 2560) to control all imputed data. When someone tries to steal a bicycle forcefully, the microcontroller will make the alarm sound and send the WhatsApp (WA) number of the bicycle owner to the raspberry pi. Furthermore, the raspberry pi will send the WA number to the Twilio application that programming interface (API) to be able to send a "stolen bicycle" message to the owner. The results showed that the BiSS had worked well with a success rate of 96% and all sensors could work optimally. When a thievery occurs, this system can send WA messages to bicycle owners with an average delivery time of 5.3 seconds. [ABSTRACT FROM AUTHOR]

3D Printing Technology has received great attention from the public. Many schools are looking for breakthroughs to develop new, more innovative ways of learning using 3D printing technology. This article provides a systematic literature review of when and the application of 3D Printing in science and manufacture technology learning systems. Through an in-depth study of 3D Printing applications in schools, can be focused into six categories of "when and how" to use, namely: (1) to teach the student about 3DP; (2) to demonstrate lecturer about 3DP; (3) as a supporting equipment during teaching; (4) to create aid learning objects; and (5) to develop advantegous technologies; The results of this study are expected to increase the capability of teachers to support and develop further so that the learning process becomes more interesting and effective. [ABSTRACT FROM AUTHOR]

Learning analytics is another trendy choice for technology-enhanced learning. It is not surprising, therefore, that learning analytics is the topic of many scientific papers as a new learning process and tool to improve learning performance. Some of the most common methods used in data mining for learning analytics, include: classification and prediction, clustering, outlier detection, relationship mining, social network analysis, process mining, text mining, distillation of data for human judgment, and discovery with models. The use of analytic learning and data mining in education and learning, generally to store information related to student backgrounds, about their interactions with the learning system and to understand how students interact with learning resources, learning styles, predictions of learning outcomes and their possibilities for completing studies they successfully. With this study teachers and school managers can develop new learning tools how to apply analytic learning to improve and predict student learning success. [ABSTRACT FROM AUTHOR]

This study aims to develop an integrated character education educational comic. This educational comic is a comic that provides education through the intrinsic elements contained in comics and contains character values. The development method applied is the ADDIE development model, with steps: analysis, design, development, implementation and evaluation. The results of this study are educational comics that are integrated with character education. Based on the results of the feasibility test, the average percentage of the results of character education experts is 84.44%. The small-group test is 80.56%. The field test is 88.43%. The average percentage value obtained is 84.47%, these results indicate that the quality criteria for the interpretation of the score of integrated educational comics on character education produced to get very good scores. Based on the feasibility tests and product trials that have been carried out, the integrated character education educational comics are declared worthy of use and have character education values. [ABSTRACT FROM AUTHOR]

Skill in the 21st century that must be mastered by students is critical thinking skill. Students' critical thinking skill can be developed through the world of education. The results of observations found at Bireuen State Islamic Senior High School shows that the students at Bireuen State Islamic Senior High School have low critical thinking skill because the learning conditions tend to be passive, so they cannot explore critical ideas in solving the problems presented. These conditions cause students to only refer to the answers provided by the teaching concept, namely conventional modules to answer the problems given, without observing the problem directly. The research objective is to find out the improvement of students' critical skill through the use of free inquiry-based modules. A quasi-experimental with pre-test and post-test control group design was used in this study. The population of the study was Islamic Senior High School 4 Bireuen and Islamic Senior High School 5 Bireuen students, totalling 165. The sampling technique used random sampling, so the sample in this study amounted to 111 students. The instrument used to measure critical thinking skill is a reasoned multiple-choice test. The data were analyzed by using N gain and analyzed by using the independent sample test at a significant level of 0.05. The result of the study is p < a, which is 0.001 < 0.05. The application of the free inquiry-based module can improve students' critical thinking skill at Islamic Senior High School Bireuen. The N gain value shows 0.78, an increase in the high category. There are differences in the critical thinking skills of students in the experimental class and the control class on the concept of environmental pollution at Bireuen State Islamic Senior High School. The implication of this study is that this module can be used as an alternative teaching concept that refers to the free inquiry model, which will facilitate educators in carrying out the learning process in the classroom and guiding students in constructing their knowledge. From the results of this study, it is recommended for other researchers to increase creativity and innovation in learning such as by using free inquiry-based modules to support classroom learning so that students' critical thinking skill can be improved. [ABSTRACT FROM AUTHOR]

This study develops a song lyric integrated with E- Module that can be used as supporting learning sources on Body Defense System topic. Method used was Research and Development (R and D) with 8 stages followed by experimental design of pretest and posttest control group. Effectivity was measured by t-test on learning outcome of XI grade senior high students. As many as 30 students were used as samples. Instrument used for product development was expert, small group and large group analysis questionnaire. Effectivity was test used problems of multiple-choice questionnaire on body defense system. Based on the result of feasibility test, obtained an average score from material expert (80.2%), media expert (82.4%) teachers (74.7%), small group students (82.9%) and large group students (84.3%). Overall analysis was gained 80.9% with very decent value. This means, that the product developed was declared feasible and effective to be used as supporting learning result. Effectivity test shown that the product significantly increases learning outcome (sig. < 0.05). The conclusion of this research and development is that the song lyric video on the integrated Body Defense System e-module material is very feasible to be used in learning with the average score of material and media expert, teacher, small group and large group scale analysis of 80.9%. The product also proven to be effectively used as a supporting learning resource with n-gain score on experiment group of 0.65 which placed the media as moderate in enhancing posttest. Teacher could use this media in learning as media that might be interesting for students and make them easier to learn. To conclude, the product developed are decent to be used and able to increase understanding on body defense system material of students. Teacher could use this media in learning as media that might be interesting for students and make them easier to learn system on body defense. [ABSTRACT FROM AUTHOR]

6-pyruvoyl-tetrahydropterin synthase (PTPS) or tetrahydrobiopterin (BH4) deficiency is the most common enzyme synthesis defect which was reported to cause of hyperphenylalaninemia. This deficiency is caused by pathogenic variant in exons and introns of 6-pyruvoyl-tetrahydropterin synthase (PTS) gene in chromosome 11q22.3-q23.3. This study is focused on the detection of DNA variants in intron 3 especially for insertion and base alteration. Methods that has been carried out in this study are DNA isolation, polymerase chain reaction (PCR), the visualization of PCR products through DNA electrophoresis, and Sanger sequencing. A total 29 variants have been characterized in this study, obtained from the DNA of one Indonesian PTPS patients and 33 healthy individuals as control. Those alterations were categorized into substitution and intronic insertion and located in the sequence of intron 3 and 4 of PTS gene. Further analyses are required to be performed to characterize the effect of identified variants to the splicing events of PTS mRNA. [ABSTRACT FROM AUTHOR]

Mucopolysaccharidosis type II (MPS II or Hunter Syndrome) is one of lysosomal storage disorder caused by the presence of pathogenic variant in IDS gene. The variant can be found in various exon locations. This research aimed to identify the presence of disease-causing variant that may occurs at exon 2 and 5 of IDS gene on MPS II patient, especially in Indonesia. Based on the previous research that has been conducted in a number of countries, exon 2 and 5 are the exons with the most number of variations. Analysis was conducted on 7 MPS II patient of Indonesian origin and 50 normal individuals as control that consist of 25 male or 25 female individuals. Analysis was done by going through steps of DNA isolation, amplification by polymerase chain reaction (PCR), visualization by electrophoresis, and sequencing. Research result shows that IDS gene from whole samples were successfully analyzed. This study discovered an adenine base deletion c.708+72delA in intron 5 of one healthy individual. The variant is novel and classified as likely benign. [ABSTRACT FROM AUTHOR]

Mucopolysaccharidosis type II (MPS II, OMIM 309900) is an X-linked recessive lysosomal storage disorder caused by the accumulation of heparan sulfate and dermatan sulfate due to iduronate-2-sulfatase (IDS) enzyme deficiency. To detect IDS gene mutation, DNA samples are obtained from 10 MPS II patients and 50 normal individuals, then the exon 1 of IDS gene was analyzed with Sanger sequencing. Two novel mutations are found from one male patient at the site of c.22C>A (p.Arg8=) and c.54C>A (p.Ser18Arg). Both mutations are not located in the bases which are responsible as the signal peptide cleavage site. Amino acid substitution c.54C>A (p.Ser18Arg) does not change the hydrophobic characteristic as both amino acids are hydrophobic. Therefore, those mutations do not change IDS enzyme structure nor alter the signaling pathway of IDS mRNA-ribosome complex to the endoplasmic reticulum. This study of exon 1 is the first to be performed in Indonesia. The novel mutations found in this study can contribute to a single nucleotide polymorphism (SNP) database of MPS II patients from all over the world, thus it leads to a deeper understanding of this rare disease at the molecular level. Therefore, a genotype study is needed to get a full profile of MPS II patients in Indonesia. [ABSTRACT FROM AUTHOR]