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1. Assessment of fluid responsiveness using pulse pressure variation, stroke volume variation, plethysmographic variability index, central venous pressure, and inferior vena cava variation in patients undergoing mechanical ventilation: a systematic review and meta-analysis

Author

Chaves, Renato Carneiro de Freitas, Barbas, Carmen Silvia Valente, Queiroz, Veronica Neves Fialho, Serpa Neto, Ary, Deliberato, Rodrigo Octavio, Pereira, Adriano José, Timenetsky, Karina Tavares, Silva Júnior, João Manoel, Takaoka, Flávio, de Backer, Daniel, Celi, Leo Anthony, and Corrêa, Thiago Domingos

Published
2024
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6. Potential Impact of Subphenotyping in Pharmacologic Management of Acute Respiratory Distress Syndrome.

Author

Torbic, Heather, Bulgarelli, Lucas, Deliberato, Rodrigo Octavio, and Duggal, Abhijit

Subjects
ADULT respiratory distress syndrome treatment, ADRENOCORTICAL hormones, SIMVASTATIN, ADULT respiratory distress syndrome, DRUG efficacy, INDIVIDUALIZED medicine, NEUROMUSCULAR blocking agents
Abstract

Background: Acute respiratory distress syndrome (ARDS) is an acute inflammatory process in the lungs associated with high morbidity and mortality. Previous research has studied both nonpharmacologic and pharmacologic interventions aimed at targeting this inflammatory process and improving ventilation. Hypothesis: To date, only nonpharmacologic interventions including lung protective ventilation, prone positioning, and high positive end-expiratory pressure ventilation strategies have resulted in significant improvements in patient outcomes. Given the high mortality associated with ARDS despite these advancements, interest in subphenotyping has grown, aiming to improve diagnosis and develop personalized treatment approaches. Data Collection: Previous trials evaluating pharmacologic therapies in heterogeneous populations have primarily demonstrated no positive effect, but hope to show benefit when targeting specific subphenotypes, thus increasing their efficacy, while simultaneously decreasing adverse effects. Results: Although most studies evaluating pharmacologic therapies for ARDS have not demonstrated a mortality benefit, there is limited data evaluating pharmacologic therapies in ARDS subphenotypes, which have found promising results. Neuromuscular blocking agents, corticosteroids, and simvastatin have resulted in a mortality benefit when used in patients with the hyper-inflammatory ARDS subphenotype. Therapeutic Opinion: The use of subphenotyping could revolutionize the way ARDS therapies are applied and therefore improve outcomes while also limiting the adverse effects associated with their ineffective use. Future studies should evaluate ARDS subphenotypes and their response to pharmacologic intervention to advance this area of precision medicine. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Syphilis Treatment: Systematic Review and Meta-Analysis Investigating Nonpenicillin Therapeutic Strategies

Author

Callado, Gustavo Yano, primary, Gutfreund, Maria Celidonio, additional, Pardo, Isabele, additional, Hsieh, Mariana Kim, additional, Lin, Vivian, additional, Sampson, Mindy Marie, additional, Nava, Guillermo Rodriguez, additional, Marins, Tássia Aporta, additional, Deliberato, Rodrigo Octávio, additional, Martino, Marinês Dalla Valle, additional, Holubar, Marisa, additional, Salinas, Jorge L, additional, and Marra, Alexandre R, additional

Published
2024
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15. Big data and machine learning in critical care: Opportunities for collaborative research

Author

Núñez Reiz, Antonio, Martínez Sagasti, Fernando, Álvarez González, Manuel, Blesa Malpica, Antonio, Martín Benítez, Juan Carlos, Nieto Cabrera, Mercedes, del Pino Ramírez, Ángela, Gil Perdomo, José Miguel, Prada Alonso, Jesús, Celi, Leo Anthony, Armengol de la Hoz, Miguel Ángel, Deliberato, Rodrigo, Paik, Kenneth, Pollard, Tom, Raffa, Jesse, Torres, Felipe, Mayol, Julio, Chafer, Joan, González Ferrer, Arturo, Rey, Ángel, González Luengo, Henar, Fico, Giuseppe, Lombroni, Ivana, Hernandez, Liss, López, Laura, Merino, Beatriz, Cabrera, María Fernanda, Arredondo, María Teresa, Bodí, María, Gómez, Josep, Rodríguez, Alejandro, and Sánchez García, Miguel

Published
2019
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17. Effect of procalcitonin-guided antibiotic treatment on mortality in acute respiratory infections: a patient level meta-analysis

Author

Schuetz, Philipp, Wirz, Yannick, Sager, Ramon, Christ-Crain, Mirjam, Stolz, Daiana, Tamm, Michael, Bouadma, Lila, Luyt, Charles E, Wolff, Michel, Chastre, Jean, Tubach, Florence, Kristoffersen, Kristina B, Burkhardt, Olaf, Welte, Tobias, Schroeder, Stefan, Nobre, Vandack, Wei, Long, Bucher, Heiner C, Annane, Djillali, Reinhart, Konrad, Falsey, Ann R, Branche, Angela, Damas, Pierre, Nijsten, Maarten, de Lange, Dylan W, Deliberato, Rodrigo O, Oliveira, Carolina F, Maravić-Stojković, Vera, Verduri, Alessia, Beghé, Bianca, Cao, Bin, Shehabi, Yahya, Jensen, Jens-Ulrik S, Corti, Caspar, van Oers, Jos A H, Beishuizen, Albertus, Girbes, Armand R J, de Jong, Evelien, Briel, Matthias, and Mueller, Beat

Published
2018
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19. Mechanical power of ventilation is associated with mortality in critically ill patients: an analysis of patients in two observational cohorts

Author

Serpa Neto, Ary, Deliberato, Rodrigo Octavio, Johnson, Alistair E. W., Bos, Lieuwe D., Amorim, Pedro, Pereira, Silvio Moreto, and Cazati, Denise Carnieli

Subjects
Lung diseases -- Patient outcomes -- Political aspects, Mortality -- United Kingdom -- Brazil -- Political aspects, Hospital patients -- Patient outcomes -- Political activity -- Political aspects, Health care industry
Abstract

Purpose Mechanical power (MP) may unify variables known to be related to development of ventilator-induced lung injury. The aim of this study is to examine the association between MP and mortality in critically ill patients receiving invasive ventilation for at least 48 h. Methods This is an analysis of data stored in the databases of the MIMIC-III and eICU. Critically ill patients receiving invasive ventilation for at least 48 h were included. The exposure of interest was MP. The primary outcome was in-hospital mortality. Results Data from 8207 patients were analyzed. Median MP during the second 24 h was 21.4 (16.2-28.1) J/min in MIMIC-III and 16.0 (11.7-22.1) J/min in eICU. MP was independently associated with in-hospital mortality [odds ratio per 5 J/min increase (OR) 1.06 (95% confidence interval (CI) 1.01-1.11); p = 0.021 in MIMIC-III, and 1.10 (1.02-1.18); p = 0.010 in eICU]. MP was also associated with ICU mortality, 30-day mortality, and with ventilator-free days, ICU and hospital length of stay. Even at low tidal volume, high MP was associated with in-hospital mortality [OR 1.70 (1.32-2.18); p < 0.001] and other secondary outcomes. Finally, there is a consistent increase in the risk of death with MP higher than 17.0 J/min. Conclusion High MP of ventilation is independently associated with higher in-hospital mortality and several other outcomes in ICU patients receiving invasive ventilation for at least 48 h., Author(s): Ary Serpa Neto [sup.1] [sup.2] [sup.3], Rodrigo Octavio Deliberato [sup.2] [sup.3] [sup.4], Alistair E. W. Johnson [sup.5], Lieuwe D. Bos [sup.1], Pedro Amorim [sup.6], Silvio Moreto Pereira [sup.6], Denise [...]

Published
2018
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20. Normalization of mechanical power to anthropometric indices: impact on its association with mortality in critically ill patients

Author

Serpa Neto, Ary, Deliberato, Rodrigo Octavio, Johnson, Alistair EW, Pollard, Tom J., Celi, Leo A., Pelosi, Paolo, and Gama de Abreu, Marcelo

Subjects
Medical centers, Mortality -- United Kingdom, Medical colleges, Biomedical engineering, Health care industry
Abstract

Author(s): Ary Serpa Neto [sup.1] [sup.2], Rodrigo Octavio Deliberato [sup.2], Alistair EW Johnson [sup.3], Tom J. Pollard [sup.3], Leo A. Celi [sup.3] [sup.4], Paolo Pelosi [sup.5] [sup.6], Marcelo Gama de [...]

Published
2019
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21. The authors reply

Author

Bulgarelli, Lucas, Deliberato, Rodrigo Octavio, Stone, David J., Celi, Leo Anthony, and Johnson, Alistair E. W.

Published
2019
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25. Supplemental Material - Potential Impact of Subphenotyping in Pharmacologic Management of Acute Respiratory Distress Syndrome

Author

Torbic, Heather, Bulgarelli, Lucas, Deliberato, Rodrigo Octavio, and Duggal, Abhijit

Subjects
FOS: Clinical medicine, 111199 Nutrition and Dietetics not elsewhere classified, 111702 Aged Health Care, FOS: Health sciences, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
Abstract

Supplemental Material for Potential Impact of Subphenotyping in Pharmacologic Management of Acute Respiratory Distress Syndrome by Heather Torbic, Lucas Bulgarelli, Rodrigo Octavio Deliberato, and Abhijit Duggal in Journal of Pharmacy Practice

Published
2023
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28. Effect of procalcitonin-guided antibiotic treatment on clinical outcomes in intensive care unit patients with infection and sepsis patients: a patient-level meta-analysis of randomized trials

Author

Wirz, Yannick, Meier, Marc A., Bouadma, Lila, Luyt, Charles E., Wolff, Michel, Chastre, Jean, Tubach, Florence, Schroeder, Stefan, Nobre, Vandack, Annane, Djillali, Reinhart, Konrad, Damas, Pierre, Nijsten, Maarten, Shajiei, Arezoo, deLange, Dylan W., Deliberato, Rodrigo O., Oliveira, Carolina F., Shehabi, Yahya, van Oers, Jos A. H., Beishuizen, Albertus, Girbes, Armand R. J., de Jong, Evelien, Mueller, Beat, and Schuetz, Philipp

Published
2018
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29. Identification of acute respiratory distress syndrome subphenotypes de novo using routine clinical data: a retrospective analysis of ARDS clinical trials

Author

Duggal, Abhijit, primary, Kast, Rachel, additional, Van Ark, Emily, additional, Bulgarelli, Lucas, additional, Siuba, Matthew T, additional, Osborn, Jeff, additional, Rey, Diego Ariel, additional, Zampieri, Fernando G, additional, Cavalcanti, Alexandre Biasi, additional, Maia, Israel, additional, Paisani, Denise M, additional, Laranjeira, Ligia N, additional, Serpa Neto, Ary, additional, and Deliberato, Rodrigo Octávio, additional

Published
2022
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30. 281: SUBPHENOTYPES IN COVID-19 ARDS: SECONDARY ANALYSIS OF A RANDOMIZED CLINICAL TRIAL

Author

Kast, Rachel, primary, Bulgarelli, Lucas, additional, Ark, Emily Van, additional, Osborn, Jeff, additional, Rey, Diego, additional, Siuba, Matthew, additional, Duggal, Abhijit, additional, Tomazini, Bruno, additional, Bueno, Flavia, additional, Biasi, Alexandre, additional, Sampaio, Camila, additional, Olivato, Guilherme, additional, Pereira, Adriano, additional, Dal-Pizzol, Felipe, additional, Azevedo, Luciano, additional, Neto, Ary Serpa, additional, and Deliberato, Rodrigo, additional

Published
2021
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31. 12: HETEROGENEITY OF EFFECT OF PEEP STRATEGY BY SUBPHENOTYPES DERIVED FROM CLINICAL DATA IN ARDS

Author

Kast, Rachel, primary, Bulgarelli, Lucas, additional, Van Ark, Emily, additional, Osborn, Jeff, additional, Rey, Diego, additional, Duggal, Abhijit, additional, Siuba, Matthew, additional, Biasi, Alexandre, additional, Zampieri, Fernando, additional, Maia, Israel, additional, Paisani, Denise, additional, Laranjeira, Ligia, additional, Neto, Ary Serpa, additional, and Deliberato, Rodrigo, additional

Published
2021
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35. Identification of Acute Respiratory Distress Syndrome subphenotypes denovo using routine clinical data: a retrospective analysis of ARDS clinical trials

Author

Duggal, Abhijit, primary, Kast, Rachel, additional, Van Ark, Emily, additional, Bulgarelli, Lucas, additional, Siuba, Matthew T., additional, Osborn, Jeff, additional, Rey, Diego, additional, Zampieri, Fernando G, additional, Cavalcanti, Alexandre B, additional, Maia, Israel S, additional, Paisani, Denise M, additional, Laranjeira, Ligia N, additional, Neto, Ary Serpa, additional, and Octávio Deliberato, Rodrigo, additional

Published
2021
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36. Normalization of mechanical power to anthropometric indices: impact on its association with mortality in critically ill patients

Author

Massachusetts Institute of Technology. Institute for Medical Engineering & Science, Harvard--MIT Program in Health Sciences and Technology. Laboratory for Computational Physiology, Serpa Neto, Ary, Deliberato, Rodrigo O, Johnson, Alistair Edward William, Pollard, Tom Joseph, Celi, Leo Anthony G., Pelosi, Paolo, Gama de Abreu, Marcelo, Schultz, Marcus J, Massachusetts Institute of Technology. Institute for Medical Engineering & Science, Harvard--MIT Program in Health Sciences and Technology. Laboratory for Computational Physiology, Serpa Neto, Ary, Deliberato, Rodrigo O, Johnson, Alistair Edward William, Pollard, Tom Joseph, Celi, Leo Anthony G., Pelosi, Paolo, Gama de Abreu, Marcelo, and Schultz, Marcus J

Abstract

Recently, we showed how mechanical power (MP) was associated with patient–centered outcomes in two large prospective cohorts of critically ill patients under invasive ventilation [1]. Normalization of MP, e.g., to the predicted body weight (PBW), has been put forward [2]. One recent paper showed MP normalized to PBW to be a better predictor of mortality than the absolute MP, at least in ARDS patients [3]. We here report the results of a posthoc analysis of the datasets used in our abovementioned publication [1]. We tested the hypothesis that MP normalized to three common anthropometric indexes, i.e., PBW, body mass index (BMI), and body surface area (BSA) are better predictors of in–hospital mortality than absolute MP in critically ill patients under invasive ventilation.

Published
2021

37. Mechanical power of ventilation is associated with mortality in critically ill patients: an analysis of patients in two observational cohorts

Author

Massachusetts Institute of Technology. Institute for Medical Engineering & Science, Harvard--MIT Program in Health Sciences and Technology. Laboratory for Computational Physiology, Serpa Neto, Ary, Deliberato, Rodrigo O, Johnson, Alistair E W, Bos, Lieuwe D, Amorim, Pedro, Pereira, Silvio M, Cazati, Denise C, Cordioli, Ricardo L, Correa, Thiago D, Pollard, Tom J, Schettino, Guilherme P P, Timenetsky, Karina T, Celi, Leo A, Pelosi, Paolo, Massachusetts Institute of Technology. Institute for Medical Engineering & Science, Harvard--MIT Program in Health Sciences and Technology. Laboratory for Computational Physiology, Serpa Neto, Ary, Deliberato, Rodrigo O, Johnson, Alistair E W, Bos, Lieuwe D, Amorim, Pedro, Pereira, Silvio M, Cazati, Denise C, Cordioli, Ricardo L, Correa, Thiago D, Pollard, Tom J, Schettino, Guilherme P P, Timenetsky, Karina T, Celi, Leo A, and Pelosi, Paolo

Abstract

Purpose Mechanical power (MP) may unify variables known to be related to development of ventilator-induced lung injury. The aim of this study is to examine the association between MP and mortality in critically ill patients receiving invasive ventilation for at least 48 h. Methods This is an analysis of data stored in the databases of the MIMIC–III and eICU. Critically ill patients receiving invasive ventilation for at least 48 h were included. The exposure of interest was MP. The primary outcome was in-hospital mortality. Results Data from 8207 patients were analyzed. Median MP during the second 24 h was 21.4 (16.2–28.1) J/min in MIMIC-III and 16.0 (11.7–22.1) J/min in eICU. MP was independently associated with in-hospital mortality [odds ratio per 5 J/min increase (OR) 1.06 (95% confidence interval (CI) 1.01–1.11); p = 0.021 in MIMIC-III, and 1.10 (1.02–1.18); p = 0.010 in eICU]. MP was also associated with ICU mortality, 30-day mortality, and with ventilator-free days, ICU and hospital length of stay. Even at low tidal volume, high MP was associated with in-hospital mortality [OR 1.70 (1.32–2.18); p < 0.001] and other secondary outcomes. Finally, there is a consistent increase in the risk of death with MP higher than 17.0 J/min. Conclusion High MP of ventilation is independently associated with higher in-hospital mortality and several other outcomes in ICU patients receiving invasive ventilation for at least 48 h.

Published
2021

39. Duration of antibiotic treatment using procalcitonin-guided treatment algorithms in older patients: a patient-level meta-analysis from randomized controlled trials

Author

Medische Staf Intensive Care, NVIC bedrijfsvoering, Brain, Infection & Immunity, Heilmann, Eva, Gregoriano, Claudia, Annane, Djillali, Reinhart, Konrad, Bouadma, Lila, Wolff, Michel, Chastre, Jean, Luyt, Charles-Edouard, Tubach, Florence, Branche, Angela R, Briel, Matthias, Christ-Crain, Mirjam, Welte, Tobias, Corti, Caspar, de Jong, Evelien, Nijsten, Maarten, de Lange, Dylan W, van Oers, Jos A H, Beishuizen, Albertus, Girbes, Armand R J, Deliberato, Rodrigo O, Schroeder, Stefan, Kristoffersen, Kristina B, Layios, Nathalie, Damas, Pierre, Lima, Stella S S, Nobre, Vandack, Wei, Long, Oliveira, Carolina F, Shehabi, Yahya, Stolz, Daiana, Tamm, Michael, Verduri, Alessia, Wang, Jin-Xiang, Drevet, Sabine, Gavazzi, Gaetan, Mueller, Beat, Schuetz, Philipp, Medische Staf Intensive Care, NVIC bedrijfsvoering, Brain, Infection & Immunity, Heilmann, Eva, Gregoriano, Claudia, Annane, Djillali, Reinhart, Konrad, Bouadma, Lila, Wolff, Michel, Chastre, Jean, Luyt, Charles-Edouard, Tubach, Florence, Branche, Angela R, Briel, Matthias, Christ-Crain, Mirjam, Welte, Tobias, Corti, Caspar, de Jong, Evelien, Nijsten, Maarten, de Lange, Dylan W, van Oers, Jos A H, Beishuizen, Albertus, Girbes, Armand R J, Deliberato, Rodrigo O, Schroeder, Stefan, Kristoffersen, Kristina B, Layios, Nathalie, Damas, Pierre, Lima, Stella S S, Nobre, Vandack, Wei, Long, Oliveira, Carolina F, Shehabi, Yahya, Stolz, Daiana, Tamm, Michael, Verduri, Alessia, Wang, Jin-Xiang, Drevet, Sabine, Gavazzi, Gaetan, Mueller, Beat, and Schuetz, Philipp

Published
2021

40. Duration of antibiotic treatment using procalcitonin-guided treatment algorithms in older patients: a patient-level meta-analysis from randomized controlled trials

Author

Heilmann, Eva, primary, Gregoriano, Claudia, additional, Annane, Djillali, additional, Reinhart, Konrad, additional, Bouadma, Lila, additional, Wolff, Michel, additional, Chastre, Jean, additional, Luyt, Charles-Edouard, additional, Tubach, Florence, additional, Branche, Angela R, additional, Briel, Matthias, additional, Christ-Crain, Mirjam, additional, Welte, Tobias, additional, Corti, Caspar, additional, de Jong, Evelien, additional, Nijsten, Maarten, additional, de Lange, Dylan W, additional, van Oers, Jos A H, additional, Beishuizen, Albertus, additional, Girbes, Armand R J, additional, Deliberato, Rodrigo O, additional, Schroeder, Stefan, additional, Kristoffersen, Kristina B, additional, Layios, Nathalie, additional, Damas, Pierre, additional, Lima, Stella S S, additional, Nobre, Vandack, additional, Wei, Long, additional, Oliveira, Carolina F, additional, Shehabi, Yahya, additional, Stolz, Daiana, additional, Tamm, Michael, additional, Verduri, Alessia, additional, Wang, Jin-Xiang, additional, Drevet, Sabine, additional, Gavazzi, Gaetan, additional, Mueller, Beat, additional, and Schuetz, Philipp, additional

Published
2021
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41. Developing well-calibrated illness severity scores for decision support in the critically ill

Author

Harvard University--MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology. Institute for Medical Engineering & Science, Harvard--MIT Program in Health Sciences and Technology. Laboratory for Computational Physiology, MIT Critical Data (Laboratory), Cosgriff, Christopher V., Celi, Leo Anthony G., Ko, Stephanie, Sundaresan, Tejas, Armengol de la Hoz, Miguel Ángel, Kaufman, Aaron Russell, Stone, David J, Badawi, Omar, Deliberato, Rodrigo, Harvard University--MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology. Institute for Medical Engineering & Science, Harvard--MIT Program in Health Sciences and Technology. Laboratory for Computational Physiology, MIT Critical Data (Laboratory), Cosgriff, Christopher V., Celi, Leo Anthony G., Ko, Stephanie, Sundaresan, Tejas, Armengol de la Hoz, Miguel Ángel, Kaufman, Aaron Russell, Stone, David J, Badawi, Omar, and Deliberato, Rodrigo

Abstract

Illness severity scores are regularly employed for quality improvement and benchmarking in the intensive care unit, but poor generalization performance, particularly with respect to probability calibration, has limited their use for decision support. These models tend to perform worse in patients at a high risk for mortality. We hypothesized that a sequential modeling approach wherein an initial regression model assigns risk and all patients deemed high risk then have their risk quantified by a second, high-risk-specific, regression model would result in a model with superior calibration across the risk spectrum. We compared this approach to a logistic regression model and a sophisticated machine learning approach, the gradient boosting machine. The sequential approach did not have an effect on the receiver operating characteristic curve or the precision-recall curve but resulted in improved reliability curves. The gradient boosting machine achieved a small improvement in discrimination performance and was similarly calibrated to the sequential models., National Institutes of Health (U.S.) (Grant EB017205)

Published
2020

43. Effect of procalcitonin-guided antibiotic treatment on clinical outcomes in intensive care unit patients with infection and sepsis patients: a patient-level meta-analysis of randomized trials

Author

Infection & Immunity, NVIC, MICU, Medische Staf Intensive Care, Wirz, Yannick, Meier, Marc A, Bouadma, Lila, Luyt, Charles E, Wolff, Michel, Chastre, Jean, Tubach, Florence, Schroeder, Stefan, Nobre, Vandack, Annane, Djillali, Reinhart, Konrad, Damas, Pierre, Nijsten, Maarten, Shajiei, Arezoo, deLange, Dylan W, Deliberato, Rodrigo O, Oliveira, Carolina F, Shehabi, Yahya, van Oers, Jos A H, Beishuizen, Albertus, Girbes, Armand R J, de Jong, Evelien, Mueller, Beat, Schuetz, Philipp, Infection & Immunity, NVIC, MICU, Medische Staf Intensive Care, Wirz, Yannick, Meier, Marc A, Bouadma, Lila, Luyt, Charles E, Wolff, Michel, Chastre, Jean, Tubach, Florence, Schroeder, Stefan, Nobre, Vandack, Annane, Djillali, Reinhart, Konrad, Damas, Pierre, Nijsten, Maarten, Shajiei, Arezoo, deLange, Dylan W, Deliberato, Rodrigo O, Oliveira, Carolina F, Shehabi, Yahya, van Oers, Jos A H, Beishuizen, Albertus, Girbes, Armand R J, de Jong, Evelien, Mueller, Beat, and Schuetz, Philipp

Published
2018

44. Effect of procalcitonin-guided antibiotic treatment on mortality in acute respiratory infections: A patient level meta-analysis

Author

Infection & Immunity, NVIC bedrijfsvoering, MICU, UMC Utrecht, Schuetz, Philipp, Wirz, Yannick, Sager, Ramon, Christ-Crain, Mirjam, Stolz, Daiana, Tamm, Michael, Bouadma, Lila, Luyt, Charles E, Wolff, Michel, Chastre, Jean, Tubach, Florence, Kristoffersen, Kristina B, Burkhardt, Olaf, Welte, Tobias, Schroeder, Stefan, Nobre, Vandack, Wei, Long, Bucher, Heiner C, Annane, Djillali, Reinhart, Konrad, Falsey, Ann R, Branche, Angela, Damas, Pierre, Nijsten, Maarten W N, de Lange, Dylan W., Deliberato, Rodrigo O, Oliveira, Carolina F, Maravić-Stojković, Vera, Verduri, Alessia, Beghé, Bianca, Cao, Bin, Shehabi, Yahya, Jensen, Jens-Ulrik S, Corti, Caspar, van Oers, Jos A H, Beishuizen, Albertus, Girbes, Armand R.J., de Jong, Evelien, Briel, Matthias, Mueller, Beat, Infection & Immunity, NVIC bedrijfsvoering, MICU, UMC Utrecht, Schuetz, Philipp, Wirz, Yannick, Sager, Ramon, Christ-Crain, Mirjam, Stolz, Daiana, Tamm, Michael, Bouadma, Lila, Luyt, Charles E, Wolff, Michel, Chastre, Jean, Tubach, Florence, Kristoffersen, Kristina B, Burkhardt, Olaf, Welte, Tobias, Schroeder, Stefan, Nobre, Vandack, Wei, Long, Bucher, Heiner C, Annane, Djillali, Reinhart, Konrad, Falsey, Ann R, Branche, Angela, Damas, Pierre, Nijsten, Maarten W N, de Lange, Dylan W., Deliberato, Rodrigo O, Oliveira, Carolina F, Maravić-Stojković, Vera, Verduri, Alessia, Beghé, Bianca, Cao, Bin, Shehabi, Yahya, Jensen, Jens-Ulrik S, Corti, Caspar, van Oers, Jos A H, Beishuizen, Albertus, Girbes, Armand R.J., de Jong, Evelien, Briel, Matthias, and Mueller, Beat

Published
2018

45. Procalcitonin-guided Antibiotic Treatment in Patients With Positive Blood Cultures: A Patient-level Meta-analysis of Randomized Trials

Author

Meier, Marc A, primary, Branche, Angela, additional, Neeser, Olivia L, additional, Wirz, Yannick, additional, Haubitz, Sebastian, additional, Bouadma, Lila, additional, Wolff, Michel, additional, Luyt, Charles E, additional, Chastre, Jean, additional, Tubach, Florence, additional, Christ-Crain, Mirjam, additional, Corti, Caspar, additional, Jensen, Jens-Ulrik S, additional, Deliberato, Rodrigo O, additional, Kristoffersen, Kristina B, additional, Damas, Pierre, additional, Nobre, Vandack, additional, Oliveira, Carolina F, additional, Shehabi, Yahya, additional, Stolz, Daiana, additional, Tamm, Michael, additional, Mueller, Beat, additional, and Schuetz, Philipp, additional

Published
2018
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46. Procalcitonin-guided antibiotic therapy algorithms for different types of acute respiratory infections based on previous trials

Author

Schuetz, Philipp, primary, Bolliger, Rebekka, additional, Merker, Meret, additional, Christ-Crain, Mirjam, additional, Stolz, Daiana, additional, Tamm, Michael, additional, Luyt, Charles E, additional, Wolff, Michel, additional, Schroeder, Stefan, additional, Nobre, Vandack, additional, Reinhart, Konrad, additional, Branche, Angela, additional, Damas, Pierre, additional, Nijsten, Maarten, additional, Deliberato, Rodrigo O., additional, Verduri, Alessia, additional, Beghé, Bianca, additional, Cao, Bin, additional, Shehabi, Yahya, additional, Jensen, Jens-Ulrik S., additional, Beishuizen, Albertus, additional, de Jong, Evelien, additional, Briel, Matthias, additional, Welte, Tobias, additional, and Mueller, Beat, additional

Published
2018
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47. Foreword

Author

Celi, Leo Anthony, primary, Deliberato, Rodrigo, additional, and Vieira, Susana, additional

Published
2018
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49. Severity of Illness Scores May Misclassify Critically Ill Obese Patients.

Author

Octávio Deliberato, Rodrigo, Ko, Stephanie, Komorowski, Matthieu, de La Hoz, M. A. Armengol, Frushicheva, Maria P., Raffa, Jesse D., Johnson, Alistair E. W., Celi, Leo Anthony, Stone, David J., Deliberato, Rodrigo Octávio, de La Hoz, Miguel Angel Armengol, and Armengol de La Hoz, M A

Subjects
*CRITICALLY ill, *INTENSIVE care units, *CANDIDEMIA, *BIOAVAILABILITY, *RADIO frequency identification systems, *MEDICAL care
Abstract

Objective: Severity of illness scores rest on the assumption that patients have normal physiologic values at baseline and that patients with similar severity of illness scores have the same degree of deviation from their usual state. Prior studies have reported differences in baseline physiology, including laboratory markers, between obese and normal weight individuals, but these differences have not been analyzed in the ICU. We compared deviation from baseline of pertinent ICU laboratory test results between obese and normal weight patients, adjusted for the severity of illness.Design: Retrospective cohort study in a large ICU database.Setting: Tertiary teaching hospital.Patients: Obese and normal weight patients who had laboratory results documented between 3 days and 1 year prior to hospital admission.Interventions: None.Measurements and Main Results: Seven hundred sixty-nine normal weight patients were compared with 1,258 obese patients. After adjusting for the severity of illness score, age, comorbidity index, baseline laboratory result, and ICU type, the following deviations were found to be statistically significant: WBC 0.80 (95% CI, 0.27-1.33) × 10/L; p = 0.003; log (blood urea nitrogen) 0.01 (95% CI, 0.00-0.02); p = 0.014; log (creatinine) 0.03 (95% CI, 0.02-0.05), p < 0.001; with all deviations higher in obese patients. A logistic regression analysis suggested that after adjusting for age and severity of illness at least one of these deviations had a statistically significant effect on hospital mortality (p = 0.009).Conclusions: Among patients with the same severity of illness score, we detected clinically small but significant deviations in WBC, creatinine, and blood urea nitrogen from baseline in obese compared with normal weight patients. These small deviations are likely to be increasingly important as bigger data are analyzed in increasingly precise ways. Recognition of the extent to which all critically ill patients may deviate from their own baseline may improve the objectivity, precision, and generalizability of ICU mortality prediction and severity adjustment models. [ABSTRACT FROM AUTHOR]

Published
2018
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50. First Brazilian datathon in critical care

Author

Serpa Neto, Ary, primary, Kugener, Guillaume, additional, Bulgarelli, Lucas, additional, Rabello Filho, Roberto, additional, Hoz, Miguel Ángel Armengol de la, additional, Johnson, Alistair EW, additional, Paik, Kenneth E, additional, Torres, Felipe, additional, Xie, Chen, additional, Amaro Júnior, Edson, additional, Ferraz, Leonardo José Rolim, additional, Celi, Leo Anthony, additional, and Deliberato, Rodrigo Octavio, additional

Published
2018
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