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2. Differential response of immobile (pneumocytes) and mobile (monocytes) barriers against 2 types of metal oxide nanoparticles

Author

Ispanixtlahuatl-Meráz, Octavio, Delgado-Buenrostro, Norma L., Déciga-Alcaraz, Alejandro, Ramos-Godinez, María del Pilar, Oliva-Rico, Diego, López-Villegas, Edgar O., Vázquez-Zapién, Gustavo J., Mata-Miranda, Mónica M., Ilhuicatzi-Alvarado, Damaris, Moreno-Fierros, Leticia, García Cuellar, Claudia M., Sánchez-Pérez, Yesennia, and Chirino, Yolanda I.

Published
2021
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3. Food-grade titanium dioxide (E171) induces anxiety, adenomas in colon and goblet cells hyperplasia in a regular diet model and microvesicular steatosis in a high fat diet model

Author

Medina-Reyes, Estefany I., Delgado-Buenrostro, Norma L., Díaz-Urbina, Daniel, Rodríguez-Ibarra, Carolina, Déciga-Alcaraz, Alejandro, González, Marisol I., Reyes, José L., Villamar-Duque, Tomás E., Flores-Sánchez, María LO., Hernández-Pando, Rogelio, Mancilla-Díaz, Juan M., Chirino, Yolanda I., and Pedraza-Chaverri, José

Published
2020
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4. Toxicity of engineered nanomaterials with different physicochemical properties and the role of protein corona on cellular uptake and intrinsic ROS production

Author

Déciga-Alcaraz, Alejandro, Medina-Reyes, Estefany I., Delgado-Buenrostro, Norma L., Rodríguez-Ibarra, Carolina, Ganem-Rondero, Adriana, Vázquez-Zapién, Gustavo J., Mata-Miranda, Mónica M., Limón-Pacheco, Jorge H., García-Cuéllar, Claudia M., Sánchez-Pérez, Yesennia, and Chirino, Yolanda I.

Published
2020
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6. Irreversible disruption of the cytoskeleton as induced by non-cytotoxic exposure to titanium dioxide nanoparticles in lung epithelial cells

Author

Déciga-Alcaraz, Alejandro, Delgado-Buenrostro, Norma L., Ispanixtlahuatl-Meráz, Octavio, Freyre-Fonseca, Verónica, Flores-Flores, José O., Ganem-Rondero, Adriana, Vaca-Paniagua, Felipe, Pilar Ramos-Godinez, María del, Morales-Barcenas, Rocío, Sánchez-Pérez, Yesennia, García-Cuéllar, Claudia M., and Chirino, Yolanda I.

Published
2020
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10. Reply to Kaminski, N.E.; Cohen, S.M. Comment on “Bischoff et al. The Effects of the Food Additive Titanium Dioxide (E171) on Tumor Formation and Gene Expression in the Colon of a Transgenic Mouse Model for Colorectal Cancer. Nanomaterials 2022, 12, 1256”

Author

Bischoff, Nicolaj S., primary, Proquin, Héloïse, additional, Jetten, Marlon J., additional, Schrooders, Yannick, additional, Jonkhout, Marloes C. M., additional, Briedé, Jacco J., additional, van Breda, Simone G., additional, Jennen, Danyel G. J., additional, Medina-Reyes, Estefany I., additional, Delgado-Buenrostro, Norma L., additional, Chirino, Yolanda I., additional, van Loveren, Henk, additional, and de Kok, Theo M., additional

Published
2023
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11. Data from Lack of STAT6 Attenuates Inflammation and Drives Protection against Early Steps of Colitis-Associated Colon Cancer

Author

Leon-Cabrera, Sonia A., primary, Molina-Guzman, Emmanuel, primary, Delgado-Ramirez, Yael G., primary, Vázquez-Sandoval, Armando, primary, Ledesma-Soto, Yadira, primary, Pérez-Plasencia, Carlos G., primary, Chirino, Yolanda I., primary, Delgado-Buenrostro, Norma L., primary, Rodríguez-Sosa, Miriam, primary, Vaca-Paniagua, Felipe, primary, Ávila-Moreno, Federico, primary, Gutierrez-Cirlos, Emma B., primary, Arias-Romero, Luis E., primary, and Terrazas, Luis I., primary

Published
2023
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12. Supplementary Table 1 from Lack of STAT6 Attenuates Inflammation and Drives Protection against Early Steps of Colitis-Associated Colon Cancer

Author

Leon-Cabrera, Sonia A., primary, Molina-Guzman, Emmanuel, primary, Delgado-Ramirez, Yael G., primary, Vázquez-Sandoval, Armando, primary, Ledesma-Soto, Yadira, primary, Pérez-Plasencia, Carlos G., primary, Chirino, Yolanda I., primary, Delgado-Buenrostro, Norma L., primary, Rodríguez-Sosa, Miriam, primary, Vaca-Paniagua, Felipe, primary, Ávila-Moreno, Federico, primary, Gutierrez-Cirlos, Emma B., primary, Arias-Romero, Luis E., primary, and Terrazas, Luis I., primary

Published
2023
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13. Reply to Kaminski, N.E.; Cohen, S.M. Comment on 'Bischoff et al. The Effects of the Food Additive Titanium Dioxide (E171) on Tumor Formation and Gene Expression in the Colon of a Transgenic Mouse Model for Colorectal Cancer. 2022, , 1256'

Author

Bischoff, Nicolaj S, Proquin, Héloïse, Jetten, Marlon J, Schrooders, Yannick, Jonkhout, Marloes C M, Briedé, Jacco J, van Breda, Simone G, Jennen, Danyel G J, Medina-Reyes, Estefany I, Delgado-Buenrostro, Norma L, Chirino, Yolanda I, van Loveren, Henk, and de Kok, Theo M

Published
2023

15. Mexican Colorectal Cancer Research Consortium (MEX-CCRC): Etiology, Diagnosis/Prognosis, and Innovative Therapies

Author

Andrade-Meza, Antonio, primary, Arias-Romero, Luis E., additional, Armas-López, Leonel, additional, Ávila-Moreno, Federico, additional, Chirino, Yolanda I., additional, Delgado-Buenrostro, Norma L., additional, García-Castillo, Verónica, additional, Gutiérrez-Cirlos, Emma B., additional, Juárez-Avelar, Imelda, additional, Leon-Cabrera, Sonia, additional, Mendoza-Rodríguez, Mónica G., additional, Olguín, Jonadab E., additional, Perez-Lopez, Araceli, additional, Pérez-Plasencia, Carlos, additional, Reyes, José L., additional, Sánchez-Pérez, Yesennia, additional, Terrazas, Luis I., additional, Vaca-Paniagua, Felipe, additional, Villamar-Cruz, Olga, additional, and Rodríguez-Sosa, Miriam, additional

Published
2023
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16. Correction: Bischoff et al. The Effects of the Food Additive Titanium Dioxide (E171) on Tumor Formation and Gene Expression in the Colon of a Transgenic Mouse Model for Colorectal Cancer. Nanomaterials 2022, 12 , 1256.

Author

Bischoff, Nicolaj S., Proquin, Héloïse, Jetten, Marlon J., Schrooders, Yannick, Jonkhout, Marloes C. M., Briedé, Jacco J., van Breda, Simone G., Jennen, Danyel G. J., Medina-Reyes, Estefany I., Delgado-Buenrostro, Norma L., Chirino, Yolanda I., van Loveren, Henk, and de Kok, Theo M.

Subjects
TRANSGENIC mice, TITANIUM dioxide, LABORATORY mice, COLORECTAL cancer, GENE expression, FOOD additives, IRINOTECAN
Abstract

This document is a correction notice for an article titled "The Effects of the Food Additive Titanium Dioxide (E171) on Tumor Formation and Gene Expression in the Colon of a Transgenic Mouse Model for Colorectal Cancer." The correction includes changes to the affiliations of one of the authors and text corrections related to the histopathology samples. The corrections involve the removal of references to lymphoid hyperplasia and the replacement of certain figures. The authors state that these corrections do not affect the scientific conclusions of the study. [Extracted from the article]

Published
2023
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17. The Effects of the Food Additive Titanium Dioxide (E171) on Tumor Formation and Gene Expression in the Colon of a Transgenic Mouse Model for Colorectal Cancer

Author

Bischoff, Nicolaj S., primary, Proquin, Héloïse, additional, Jetten, Marlon J., additional, Schrooders, Yannick, additional, Jonkhout, Marloes C. M., additional, Briedé, Jacco J., additional, van Breda, Simone G., additional, Jennen, Danyel G. J., additional, Medina-Reyes, Estefany I., additional, Delgado-Buenrostro, Norma L., additional, Chirino, Yolanda I., additional, van Loveren, Henk, additional, and de Kok, Theo M., additional

Published
2022
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19. STAT1 Is Required for Decreasing Accumulation of Granulocytic Cells via IL-17 during Initial Steps of Colitis-Associated Cancer

Author

Delgado-Ramirez, Yael, primary, Baltazar-Perez, Itzel, additional, Martinez, Yamileth, additional, Callejas, Blanca E., additional, Medina-Andrade, Itzel, additional, Olguín, Jonadab E., additional, Delgado-Buenrostro, Norma L., additional, Chirino, Yolanda I., additional, Terrazas, Luis I., additional, and Leon-Cabrera, Sonia, additional

Published
2021
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20. Combination of Metformin, Sodium Oxamate and Doxorubicin Induces Apoptosis and Autophagy in Colorectal Cancer Cells via Downregulation HIF-1α

Author

Coronel-Hernández, Jossimar, primary, Salgado-García, Rebeca, additional, Cantú-De León, David, additional, Jacobo-Herrera, Nadia, additional, Millan-Catalan, Oliver, additional, Delgado-Waldo, Izamary, additional, Campos-Parra, Alma D., additional, Rodríguez-Morales, Miguel, additional, Delgado-Buenrostro, Norma L., additional, and Pérez-Plasencia, Carlos, additional

Published
2021
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22. Use of STAT6 Phosphorylation Inhibitor and Trimethylglycine as New Adjuvant Therapies for 5-Fluorouracil in Colitis-Associated Tumorigenesis

Author

Mendoza-Rodríguez, Mónica G., primary, Sánchez-Barrera, C. Ángel, additional, Callejas, Blanca E., additional, García-Castillo, Verónica, additional, Beristain-Terrazas, Diana L., additional, Delgado-Buenrostro, Norma L., additional, Chirino, Yolanda I., additional, León-Cabrera, Sonia A., additional, Rodríguez-Sosa, Miriam, additional, Gutierrez-Cirlos, Emma Bertha, additional, Pérez-Plasencia, Carlos, additional, Vaca-Paniagua, Felipe, additional, Meraz-Ríos, Marco Antonio, additional, and Terrazas, Luis I., additional

Published
2020
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23. Differences in cytotoxicity of lung epithelial cells exposed to titanium dioxide nanofibers and nanoparticles: Comparison of air-liquid interface and submerged cell cultures

Author

Medina-Reyes, Estefany I, Delgado-Buenrostro, Norma L, Leseman, Daan L, Déciga-Alcaraz, Alejandro, He, Ruiwen, Gremmer, Eric R, Fokkens, Paul H B, Flores-Flores, José O, Cassee, Flemming R, Chirino, Yolanda I, One Health Toxicologie, IRAS OH Toxicology, dIRAS RA-1, One Health Toxicologie, IRAS OH Toxicology, and dIRAS RA-1

Subjects
0301 basic medicine, Cell Survival, media_common.quotation_subject, Cytotoxicity, Cell Culture Techniques, Nanofibers, Nanoparticle, TiO(2) nanoparticles, Toxicology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Humans, TiO(2) nanofibers, ROS production, Internalization, Lung, media_common, Titanium, Air liquid Interface system, Chemistry, Air, General Medicine, TiO2 nanofibers, 030104 developmental biology, Cell culture, Cytoplasm, A549 Cells, 030220 oncology & carcinogenesis, Nanofiber, Titanium dioxide, Toxicity, Biophysics, DNA damage, Nanoparticles, Reactive Oxygen Species, TiO2 nanoparticles, DNA Damage
Abstract

Air Liquid Interface (ALI) system has emerged as a useful tool for toxicity evaluation of nanomaterials related to inhalation since the system mimics the aerosol exposure. We compared the biological responses of lung epithelial cells exposed to titanium dioxide (TiO2) nanofibers and nanoparticles in ALI and submerged cell cultures systems. Cells were exposed to 2 and 10 μg/cm2 for 24 h, 48 h and 72 h and LDH release, TiO2 internalization, DNA-double strand breaks (DSBs) and ROS production were assessed. LDH release was similar in both systems and particles had higher cytoplasmic uptake in submerged systems. Both TiO2 types were located in the cytoplasm but nanofibers had nuclear uptake regardless to the system tested. Cells exposed to TiO2 nanofibers had higher DSBs in the ALI system than in submerged cell cultures but cells exposed to TiO2 nanoparticles had similar DSBs in both systems. ROS production was higher in cells exposed to TiO2 nanofibers compared to cells exposed to TiO2 nanoparticles. In conclusion, cytotoxicity of lung epithelial cells was similar in ALI or submerged cell cultures, however cells exposed to TiO2 nanofibers displayed higher toxicity than cells exposed to TiO2 nanoparticles.

Published
2019

24. Differences in cytotoxicity of lung epithelial cells exposed to titanium dioxide nanofibers and nanoparticles: Comparison of air-liquid interface and submerged cell cultures

Author

Medina-Reyes, Estefany I, Delgado-Buenrostro, Norma L, Leseman, Daan L, Déciga-Alcaraz, Alejandro, He, Ruiwen, Gremmer, Eric R, Fokkens, Paul H B, Flores-Flores, José O, Cassee, Flemming R, Chirino, Yolanda I, Medina-Reyes, Estefany I, Delgado-Buenrostro, Norma L, Leseman, Daan L, Déciga-Alcaraz, Alejandro, He, Ruiwen, Gremmer, Eric R, Fokkens, Paul H B, Flores-Flores, José O, Cassee, Flemming R, and Chirino, Yolanda I

Published
2020

25. Differences in cytotoxicity of lung epithelial cells exposed to titanium dioxide nanofibers and nanoparticles: Comparison of air-liquid interface and submerged cell cultures

Author

One Health Toxicologie, IRAS OH Toxicology, dIRAS RA-1, Medina-Reyes, Estefany I, Delgado-Buenrostro, Norma L, Leseman, Daan L, Déciga-Alcaraz, Alejandro, He, Ruiwen, Gremmer, Eric R, Fokkens, Paul H B, Flores-Flores, José O, Cassee, Flemming R, Chirino, Yolanda I, One Health Toxicologie, IRAS OH Toxicology, dIRAS RA-1, Medina-Reyes, Estefany I, Delgado-Buenrostro, Norma L, Leseman, Daan L, Déciga-Alcaraz, Alejandro, He, Ruiwen, Gremmer, Eric R, Fokkens, Paul H B, Flores-Flores, José O, Cassee, Flemming R, and Chirino, Yolanda I

Published
2020

26. Helminth‐derived molecules inhibit colitis‐associated colon cancer development through NF‐κB and STAT3 regulation

Author

Callejas, Blanca E., primary, Mendoza‐Rodríguez, Mónica G., additional, Villamar‐Cruz, Olga, additional, Reyes‐Martínez, Sandy, additional, Sánchez‐Barrera, Cuauhtémoc Angel, additional, Rodríguez‐Sosa, Miriam, additional, Delgado‐Buenrostro, Norma L., additional, Martínez‐Saucedo, Diana, additional, Chirino, Yolanda I., additional, León‐Cabrera, Sonia A., additional, Pérez‐Plasencia, Carlos, additional, Vaca‐Paniagua, Felipe, additional, Arias‐Romero, Luis E., additional, and Terrazas, Luis I., additional

Published
2019
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27. Food-grade titanium dioxide (E171) by solid or liquid matrix administration induces inflammation, germ cells sloughing in seminiferous tubules and blood-testis barrier disruption in mice

Author

Rodríguez-Escamilla, Juan Carlos, primary, Medina-Reyes, Estefany I., additional, Rodríguez-Ibarra, Carolina, additional, Déciga-Alcaraz, Alejandro, additional, Flores-Flores, José O., additional, Ganem-Rondero, Adriana, additional, Rodríguez-Sosa, Miriam, additional, Terrazas, Luis I., additional, Delgado-Buenrostro, Norma L., additional, and Chirino, Yolanda I., additional

Published
2019
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28. Titanium dioxide nanofibers induce angiogenic markers and genomic instability in lung cells leading to a highly dedifferentiated and fibrotic tumor formation in a xenograft model

Author

Medina-Reyes, Estefany I., primary, Delgado-Buenrostro, Norma L., additional, Déciga-Alcaraz, Alejandro, additional, Freyre-Fonseca, Verónica, additional, Flores-Flores, José O., additional, Hernández-Pando, Rogelio, additional, Barrios-Payán, Jorge, additional, Carrero, Julio C., additional, Sánchez-Pérez, Yesennia, additional, García-Cuéllar, Claudia M., additional, Vaca-Paniagua, Felipe, additional, and Chirino, Yolanda I., additional

Published
2019
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29. Lack of STAT6 Attenuates Inflammation and Drives Protection against Early Steps of Colitis-Associated Colon Cancer

Author

Leon-Cabrera, Sonia A., primary, Molina-Guzman, Emmanuel, additional, Delgado-Ramirez, Yael G., additional, Vázquez-Sandoval, Armando, additional, Ledesma-Soto, Yadira, additional, Pérez-Plasencia, Carlos G., additional, Chirino, Yolanda I., additional, Delgado-Buenrostro, Norma L., additional, Rodríguez-Sosa, Miriam, additional, Vaca-Paniagua, Felipe, additional, Ávila-Moreno, Federico, additional, Gutierrez-Cirlos, Emma B., additional, Arias-Romero, Luis E., additional, and Terrazas, Luis I., additional

Published
2017
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30. Nrf2 protects the lung against inflammation induced by titanium dioxide nanoparticles: A positive regulator role of Nrf2 on cytokine release

Author

Delgado-Buenrostro, Norma L., Lastres-Becker, Isabel, Pedraza-Chaverri, José, Espada, Sandra, Cuadrado, Antonio, Chirino, Yolanda I., Consejo Nacional de Ciencia y Tecnología (México), Universidad Nacional Autónoma de México, Secretaría de Educación Pública (México), and Ministerio de Economía y Competitividad (España)

Subjects
respiratory system, health care economics and organizations
Abstract

et al., Titanium dioxide nanoparticles (TiO2 NPs) have been classified as possibly carcinogenic to humans and they are an important nanomaterial widely used in pharmaceutical and paint industries. Inhalation is one of the most important routes of exposure in occupational settings. Several experimental models have shown that oxidative stress and inflammation are key mediators of cell damage. In this regard, Nrf2 modulates cytoprotection against oxidative stress and inflammation, however, its role in inflammation induced by TiO2 NPs exposure has been less investigated. The aim of this work was to investigate the role of Nrf2 in the cytokines produced after 4 weeks of TiO2 NPs exposure (5 mg/kg/2 days/week) using wild-type and Nrf2 knockout C57bl6 mice. Results showed that Nrf2 protects against inflammation and oxidative damage induced by TiO2 NPs exposure, however, Nrf2 is a positive mediator in the expression of IFN-γ, TNF-α, and TGF-β in bronchial epithelium and alveolar space after 4 weeks of exposure. These results suggest that Nrf2 has a central role in up-regulation of cytokines released during inflammation induced by TiO2 NPs and those cytokines are needed to cope with histological alterations in lung tissue., Funded by: CONACyT. Grant Numbers: 166727, 129838; DGAPA PAPIIT. Grant Numbers: IB201112, IN210713; Spanish Ministry of Economy and Competitiveness. Grant Number: SAF2010-17822; FES-Iztacala. Grant Number: Project 28; CONACyT and Escuela Nacional de Ciencias Biológicas at Instituto Politécnico Nacional (Doctorado en Ciencias en Alimentos). Grant Number: 202805.

Published
2015

32. Nrf2 protects the lung against inflammation induced by titanium dioxide nanoparticles: A positive regulator role of Nrf2 on cytokine release

Author

Delgado-Buenrostro, Norma L., primary, Medina-Reyes, Estefany I., additional, Lastres-Becker, Isabel, additional, Freyre-Fonseca, Verónica, additional, Ji, Zhaoxia, additional, Hernández-Pando, Rogelio, additional, Marquina, Brenda, additional, Pedraza-Chaverri, José, additional, Espada, Sandra, additional, Cuadrado, Antonio, additional, and Chirino, Yolanda I., additional

Published
2014
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33. Nrf2 protects the lung against inflammation induced by titanium dioxide nanoparticles: A positive regulator role of Nrf2 on cytokine release.

Author

Delgado‐Buenrostro, Norma L., Medina‐Reyes, Estefany I., Lastres‐Becker, Isabel, Freyre‐Fonseca, Verónica, Ji, Zhaoxia, Hernández‐Pando, Rogelio, Marquina, Brenda, Pedraza‐Chaverri, José, Espada, Sandra, Cuadrado, Antonio, and Chirino, Yolanda I.

Subjects
TITANIUM dioxide nanoparticles, INFLAMMATION treatment, NANOSTRUCTURED materials, OXIDATIVE stress, CYTOKINE receptors, CYTOPROTECTION
Abstract

ABSTRACT Titanium dioxide nanoparticles (TiO2 NPs) have been classified as possibly carcinogenic to humans and they are an important nanomaterial widely used in pharmaceutical and paint industries. Inhalation is one of the most important routes of exposure in occupational settings. Several experimental models have shown that oxidative stress and inflammation are key mediators of cell damage. In this regard, Nrf2 modulates cytoprotection against oxidative stress and inflammation, however, its role in inflammation induced by TiO2 NPs exposure has been less investigated. The aim of this work was to investigate the role of Nrf2 in the cytokines produced after 4 weeks of TiO2 NPs exposure (5 mg/kg/2 days/week) using wild-type and Nrf2 knockout C57bl6 mice. Results showed that Nrf2 protects against inflammation and oxidative damage induced by TiO2 NPs exposure, however, Nrf2 is a positive mediator in the expression of IFN-γ, TNF-α, and TGF-β in bronchial epithelium and alveolar space after 4 weeks of exposure. These results suggest that Nrf2 has a central role in up-regulation of cytokines released during inflammation induced by TiO2 NPs and those cytokines are needed to cope with histological alterations in lung tissue. © 2014 Wiley Periodicals, Inc. Environ Toxicol 30: 782-792, 2015. [ABSTRACT FROM AUTHOR]

Published
2015
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34. Deficiency in STAT1 Signaling Predisposes Gut Inflammation and Prompts Colorectal Cancer Development.

Author

Leon-Cabrera, Sonia, Vázquez-Sandoval, Armando, Molina-Guzman, Emmanuel, Delgado-Ramirez, Yael, Delgado-Buenrostro, Norma L., Callejas, Blanca E., Chirino, Yolanda I., Pérez-Plasencia, Carlos, Rodríguez-Sosa, Miriam, Olguín, Jonadab E., Salinas, Citlaltepetl, Satoskar, Abhay R., and Terrazas, Luis I.

Subjects
INJURY complications, SPLEEN, CELL proliferation, ANIMAL experimentation, TUMOR suppressor genes, APOPTOSIS, CANCER, CARCINOGENS, CARRIER proteins, CELLULAR signal transduction, COLITIS, COLON tumors, GENE expression, IMMUNOLOGICAL adjuvants, INTERLEUKINS, MICE, RECTUM tumors, SODIUM compounds, DISEASE complications, ANATOMY
Abstract

Signal transducer and activator of transcription 1 (STAT1) is part of the Janus kinase (JAK/STAT) signaling pathway that controls critical events in intestinal immune function related to innate and adaptive immunity. Recent studies have implicated STAT1 in tumor–stroma interactions, and its expression and activity are perturbed during colon cancer. However, the role of STAT1 during the initiation of inflammation-associated cancer is not clearly understood. To determine the role of STAT1 in colitis-associated colorectal cancer (CAC), we analyzed the tumor development and kinetics of cell recruitment in wild-type WT or STAT1−/− mice treated with azoxymethane (AOM) and dextran sodium sulfate (DSS). Following CAC induction, STAT1−/− mice displayed an accelerated appearance of inflammation and tumor formation, and increased damage and scores on the disease activity index (DAI) as early as 20 days after AOM-DSS exposure compared to their WT counterparts. STAT1−/− mice showed elevated colonic epithelial cell proliferation in early stages of injury-induced tumor formation and decreased apoptosis in advanced tumors with over-expression of the anti-apoptotic protein Bcl2 at the colon. STAT1−/− mice showed increased accumulation of Ly6G+Ly6C−CD11b+ cells in the spleen at 20 days of CAC development with concomitant increases in the production of IL-17A, IL-17F, and IL-22 cytokines compared to WT mice. Our findings suggest that STAT1 plays a role as a tumor suppressor molecule in inflammation-associated carcinogenesis, particularly during the very early stages of CAC initiation, modulating immune responses as well as controlling mechanisms such as apoptosis and cell proliferation. [ABSTRACT FROM AUTHOR]

Published
2018
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