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222 results on '"Delgado, Diego H."'

4. Canadian Cardiovascular Society/Canadian Heart Failure Society Joint Position Statement on the Evaluation and Management of Patients With Cardiac Amyloidosis

Author

Fine, Nowell M., Davis, Margot K., Anderson, Kim, Delgado, Diego H., Giraldeau, Genevieve, Kitchlu, Abhijat, Massie, Rami, Narayan, Jane, Swiggum, Elizabeth, Venner, Christopher P., Ducharme, Anique, Galant, Natalie J., Hahn, Christopher, Howlett, Jonathan G., Mielniczuk, Lisa, Parent, Marie-Claude, Reece, Donna, Royal, Virginie, Toma, Mustafa, Virani, Sean A., and Zieroth, Shelley

Published
2020
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6. CCS/CHFS Heart Failure Guidelines: Clinical Trial Update on Functional Mitral Regurgitation, SGLT2 Inhibitors, ARNI in HFpEF, and Tafamidis in Amyloidosis

Author

O’Meara, Eileen, McDonald, Michael, Chan, Michael, Ducharme, Anique, Ezekowitz, Justin A., Giannetti, Nadia, Grzeslo, Adam, Heckman, George A., Howlett, Jonathan G., Koshman, Sheri L., Lepage, Serge, Mielniczuk, Lisa M., Moe, Gordon W., Swiggum, Elizabeth, Toma, Mustafa, Virani, Sean A., Zieroth, Shelley, De, Sabe, Matteau, Sylvain, Parent, Marie-Claude, Asgar, Anita W., Cohen, Gideon, Fine, Nowell, Davis, Margot, Verma, Subodh, Cherney, David, Abrams, Howard, Al-Hesayen, Abdul, Cohen-Solal, Alain, D’Astous, Michel, Delgado, Diego H., Desplantie, Olivier, Estrella-Holder, Estrellita, Green, Lee, Haddad, Haissam, Harkness, Karen, Hernandez, Adrian F., Kouz, Simon, LeBlanc, Marie-Hélène, Lee, Douglas, Masoudi, Frederick A., McKelvie, Robert S., Rajda, Miroslaw, Ross, Heather J., and Sussex, Bruce

Published
2020
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34. Impact of fixed pulmonary hypertension on post-heart transplant outcomes in bridge-to-transplant patients

Author

Alba, Ana Carolina, Rao, Vivek, Ross, Heather J, Jensen, Annette S, Sander, Kaare, Gustafsson, Finn, Delgado, Diego H, Jensen, Annette Schophuus, Sander, Kåre, Alba, Ana Carolina, Rao, Vivek, Ross, Heather J, Jensen, Annette S, Sander, Kaare, Gustafsson, Finn, Delgado, Diego H, Jensen, Annette Schophuus, and Sander, Kåre

Abstract

Fixed pulmonary hypertension (FPH) is considered a contraindication to cardiac transplantation. Ventricular assist device (VAD) therapy through prolonged left ventricular unloading may reverse FPH. Our aim was to assess post-transplant outcomes and survival in patients with and without FPH undergoing VAD implantation as bridge to transplant.

Published
2010

35. Everolimus but not mycophenolate mofetil therapy is associated with soluble HLA-G expression in heart transplant patients

Author

Sheshgiri, Rohit, Gustafsson, Finn, Sheedy, Jill, Rao, Vivek, Ross, Heather J, Delgado, Diego H, Sheshgiri, Rohit, Gustafsson, Finn, Sheedy, Jill, Rao, Vivek, Ross, Heather J, and Delgado, Diego H

Abstract

Udgivelsesdato: 2009-Nov, BACKGROUND: Human leukocyte antigen-G (HLA-G), a protein primarily expressed during pregnancy, helps maintain maternal-fetal immune tolerance. Myocardial and/or soluble HLA-G (sHLA-G) expression confers protection against rejection and vasculopathy after heart transplantation. Although the precise mechanisms remain unclear, immunosuppressive therapy has been reported to influence this expression. METHODS: We compared sHLA-G expression in heart transplant recipients receiving two different anti-proliferative agents: mycophenolate mofetil (MMF) and everolimus (RAD). Twelve-hour pharmacokinetic (PK) studies were conducted in patients after cyclosporine (CsA) administration in conjunction with RAD or MMF, during which plasma HLA-G concentrations were measured by enzyme-linked immunoassay (ELISA). RESULTS: Among patients receiving RAD, 78% expressed detectable levels of plasma HLA-G (1,002 +/- 511 ng/ml) compared with 25% of patients receiving MMF (612 +/- 438 ng/ml, p = 0.03). In all sHLA-G(+) patients, expression remained constant, with no significant changes in HLA-G levels throughout the 12-hour PK study period. CsA did not appear to influence sHLA-G expression, as there was no correlation between HLA-G levels and CsA exposure (R(2) = 0.43, p = 0.08). CONCLUSIONS: These preliminary findings suggest a disproportionate expression of HLA-G in patients under two distinct immunosuppression strategies after heart transplantation. Although CsA administration does not influence sHLA-G levels, RAD but not MMF is associated with sHLA-G expression. Larger prospective clinical investigations are required to confirm whether RAD is independently associated with increased HLA-G expression.

Published
2009

37. Autologous stem cell transplant is an effective therapy for carefully selected patients with AL amyloidosis: experience of a single institution

Author

Jimenez‐Zepeda, Victor H., primary, Franke, Norman, additional, Reece, Donna E., additional, Trudel, Suzanne, additional, Chen, Christine, additional, Delgado, Diego H., additional, Winter, Andrew, additional, Mikhael, Joseph R., additional, Tiedemann, Rodger, additional, and Kukreti, Vishal, additional

Published
2013
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