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7. Exposure assessment of particulate matter air pollution before, during, and after the 2003 Southern California wildfires

Author

Wu, J, Winer, A M, and Delfino, R J

Subjects
particulate matter, satellite image, visibility, smoke, spatial interpolation
Abstract

Exposure to biomass smoke has been associated with increased respiratory illness and symptoms. The goal of this study was to estimate daily particulate matter (PM; PM10 and PM2.5) concentrations at a zip-code level for southern California before, during and after the 2003 southern California wildfires. On average, heavy smoke from the fires increased PM10 3 and PM2.5 concentration by 160 and 100 mu g m(-3), respectively. Missing PM concentrations from the every 3rd or 6th day routine measurements or due to the incapacitation of monitors and/or stations by the fires were estimated based on (1) temporal profiles of continuous TEOM or BAM data at co-located or closely located sites; and (2) light extinction, meteorological conditions, and smoke information extracted from MODIS satellite images at a 250 m resolution. Light extinction coefficient, smoke, and relative humidity were the most important factors strongly associated with PM concentrations, especially PM2.5. Spatial interpolations of PM concentrations were performed using inverse distance weighting (IDW), kriging or cokriging methods for the non-fire periods. Kriging was not superior to IDW in many cases due to the small number of monitoring stations. Since the fire and smoke created highly heterogeneous pollution surfaces, typical IDW and kriging could not work during the fires. Polygons were created based on satellite images to represent each smoke-covered area under different smoke densities. Concentrations were assigned to each polygon using measured or valid estimated concentrations at the corresponding monitoring stations, or at other stations under similar smoke conditions. In summary, population-weighted PM10 and PM2.5 concentrations were 190 and 90 mu gm(-3), and 125 and 75 mu g m(-3) under heavy and light smoke conditions, respectively, in contrast to concentrations of 40 and 20 mu g m(-3) for PM10 and PM2.5, respectively, during the non-fire periods. The methodology we developed in this study is also applicable to other regions to a greater or lesser extent based on the availability of satellite, visibility and air quality data. (c) 2006 Elsevier Ltd. All rights reserved.

Published
2006

8. Symptoms in pediatric asthmatics and air pollution: differences in effects by symptom severity, anti-inflammatory medication use and particulate averaging time.

Author

Delfino, R J, Zeiger, R S, Seltzer, J M, and Street, D H

Subjects
respiratory health, fine particles, los-angeles, children, ozone, responses, ultrafine, area
Abstract

Experimental research in humans and animals points to the importance of adverse respiratory effects from short-term particle exposures and to the importance of proinflammatory effects of air pollutants, particularly O(subscript)3. However, particle averaging time has not been subjected to direct scientific evaluation, and there is a lack of epidemiological research examining both this issue and whether modification of air pollutant effects occurs with differences in asthma severity and anti-inflammatory medication use. The present study examined the relationship of adverse asthma symptoms (bothersome or interfered with daily activities or sleep) to O(3) and particles (less than or equal to)10 micrometer (PM10) in a Southern California community in the air inversion zone (1200-2100 ft) with high O(3) and low PM (R = 0.3). A panel of 25 asthmatics 9-17 years of age were followed daily, August through October 1995 (n = 1,759 person-days excluding one subject without symptoms). Exposures included stationary outdoor hourly PM10 (highest 24-hr mean, 54 microgram/m(3), versus median of 1-hr maximums, 56 microgram/m(3) and O(3) (mean of 1-hr maximums, 90 ppb, 5 days (greater than or equal to)120 ppb). Longitudinal regression analyses utilized the generalized estimating equations (GEE) model controlling for autocorrelation, day of week, outdoor fungi, and weather. Asthma symptoms were significantly associated with both outdoor O(3) and PM(10) in single pollutant- and co-regressions, with 1-hr and 8-hr maximum PM(10) having larger effects than the 24-hr mean. Subgroup analyses showed effects of current day PM(10) maximums were strongest in 10 more frequently symptomatic (MS) children: the odds ratios (ORs) for adverse symptoms from 90th percentile increases were 2.24 [95% confidence interval (CI), 1.46-3.46] for 1-hr PM10 (47 microgram/m(3); 1.82 (CI, 1.18-2.81) for 8-hr PM10 (36 microgram/m(3); and 1.50 (CI, 0.80-2.80) for 24-hr PM10 (25 microgram/m(3). Subgroup analyses also showed the effect of current day O(subscript)3 was strongest in 14 less frequently symptomatic (LS) children: the ORs were 2.15 (CI, 1.04-4.44) for 1-hr O(3) (58 ppb) and 1.92 (CI, 0.97-3.80) for 8-hr O(3) (46 ppb). Effects of 24-hr PM10 were seen in both groups, particularly with 5-day moving averages (ORs were 1.95 for MS and 4. 03 for LS; p(less than or equal to)0.05). The largest effects were in 7 LS children not on anti-inflammatory medications [5-day, 8-hr PM10, 9.66 (CI, 2.80-33.21); current day, 1-hr O(3), 4.14 (CI, 1.71-11.85)]. Results suggest that examination of short-term particle excursions, medication use, and symptom severity in longitudinal studies of asthma yields sensitive measures of adverse respiratory effects of air pollution.ImagesFigure 1

Published
1998

10. Ozone exposure assessment in a southern California community.

Author

Liu, L J, Delfino, R, and Koutrakis, P

Subjects
ambient
Abstract

An ozone exposure assessment study was conducted in a Southern California community. The Harvard ozone passive sampler was used to monitor cohorts of 22 and 18 subjects for 8 weeks during the spring and fall of 1994, respectively. Ozone exposure variables included 12-hr personal O3 measurements, stationary outdoor O3 measurements from a continuous UV photometer and from 12-hr Harvard active monitors, and time-activity information. Results showed that personal O3 exposure levels averaged one-fourth of outdoor stationary O3 levels, attributable to high percentages of time spent indoors. Personal O3 levels were not predicted well by outdoor measurements. A random-effect general linear model analysis indicated that variance in personal exposure measurements was largely accounted for by random error (59-82%), followed by inter-subject (9-18%) and between-day (9-23%) random effects. The microenvironmental model performs differently by season, with the regression model for spring cohorts exhibiting two times the R2 of the fall cohorts (R2 = 0.21 vs. 0.09). When distance from the stationary monitoring site, elevation, and traffic are taken into account in the microenvironmental models, the adjusted R2 increased almost twofold for the fall personal exposure data. The low predictive power is due primarily to the apparent spatial variation of outdoor O3 and errors in O3 measurements and in time-activity records (particularly in recording the use of air conditioning). This study highlights the magnitude of O3 exposure misclassification in epidemiological settings and proposes an approach to reduce exposure uncertainties in assessing air pollution health effects.ImagesFigure 1. AFigure 1. BFigure 2. AFigure 2. BFigure 3.Figure 4.Figure 5.Figure 6.

Published
1997

11. Effect of the Deposit Temperature of ZnO Doped with Ni by HFCVD

Author

Gutiérrez, Delfino R., primary, García-Salgado, Godofredo, additional, Coyopol, Antonio, additional, Rosendo-Andrés, Enrique, additional, Romano, Román, additional, Morales, Crisóforo, additional, Benítez, Alfredo, additional, Severiano, Francisco, additional, Herrera, Ana María, additional, and Ramírez-González, Francisco, additional

Published
2023
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12. A nanoporous surface is essential for glomerular podocyte differentiation in three-dimensional culture

Author

Zennaro C, Rastaldi MP, Bakeine GJ, Delfino R, Tonon F, Farra R, Grassi G, Artero M, Tormen M, and Carraro M

Subjects
podocytes, neurons, nanotechnology, basement membrane, differentiation, adhesion, Medicine (General), R5-920
Abstract

Cristina Zennaro,1 Maria Pia Rastaldi,2 Gerald James Bakeine,3 Riccarda Delfino,1 Federica Tonon,1 Rossella Farra,4 Gabriele Grassi,1,5 Mary Artero,6 Massimo Tormen,7 Michele Carraro1 1Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, 2Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, 3Department of Radiology, San Martino University Hospital, University of Genoa, Genoa, 4Department of Engineering and Architecture, University of Trieste, 5Department of Life Sciences, Cattinara University Hospital, University of Trieste, 6Azienda Sanitaria Universitaria Integrata di Trieste, Trieste, 7IOM-CNR Area Science Park, Trieste, Italy Abstract: Although it is well recognized that cell–matrix interactions are based on both molecular and geometrical characteristics, the relationship between specific cell types and the three-dimensional morphology of the surface to which they are attached is poorly understood. This is particularly true for glomerular podocytes – the gatekeepers of glomerular filtration – which completely enwrap the glomerular basement membrane with their primary and secondary ramifications. Nanotechnologies produce biocompatible materials which offer the possibility to build substrates which differ only by topology in order to mimic the spatial organization of diverse basement membranes. With this in mind, we produced and utilized rough and porous surfaces obtained from silicon to analyze the behavior of two diverse ramified cells: glomerular podocytes and a neuronal cell line used as a control. Proper differentiation and development of ramifications of both cell types was largely influenced by topographical characteristics. Confirming previous data, the neuronal cell line acquired features of maturation on rough nanosurfaces. In contrast, podocytes developed and matured preferentially on nanoporous surfaces provided with grooves, as shown by the organization of the actin cytoskeleton stress fibers and the proper development of vinculin-positive focal adhesions. On the basis of these findings, we suggest that in vitro studies regarding podocyte attachment to the glomerular basement membrane should take into account the geometrical properties of the surface on which the tests are conducted because physiological cellular activity depends on the three-dimensional microenvironment. Keywords: podocytes, neurons, nanotechnology, basement membrane, differentiation, adhesion

Published
2016

13. Respuesta a «Carta al Director de la RECOT. Resultados funcionales y supervivencia a ocho años de la artroscopia de cadera en pacientes con patología degenerativa de cadera», de J. Sanz-Reig y J. Más-Martínez

Author

Torres-Perez, D., primary, Escribano-Rueda, L., additional, Lara-Rubio, A., additional, Gomez-Rice, A., additional, Delfino, R., additional, Martin-Nieto, E., additional, Galeote, E., additional, and Madrid-de la Serna, C., additional

Published
2022
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15. Photoluminescent Enhancement by Effect of Incorporation Nickel in ZnO Films Grown

Author

Crisóforo Morales-Ruiz, Enrique Rosendo-Andrés, Ramon Pena-Sierra, F.G. Nieto-Caballero, T. Díaz-Becerril, Antonio Coyopol-Solis, Reina Galeazzi-Isasmendi, Roman Romano-Trujillo, G. García-Salgado, and Delfino R. Gutiérrez

Subjects
Nickel, Materials science, Photoluminescence, chemistry, chemistry.chemical_element, Nuclear chemistry
Abstract

Microstructured films of undoped zinc oxide (ZnO) and ZnO doped with nickel (ZnO:Ni) were grown by hot filament chemical vapor deposition (HFCVD) technique on Si (100) substrates at 500 °C. Pellets of ZnO and ZnO:NiO as oxidant agenst were used. A shift to the right around 0.17 degree of the X-Ray Diffraction pattern of the ZnO:Ni film was observed with respect to undoped ZnO films. Morphologically by Scanning Electron Microscopy was noticed a Core-Shell type growth in ZnO undoped and a nanostructured type (Nano-wire) in ZnO doped with Ni. Photoluminescence measurements showed an increase in the intensity of the green emission band of ZnO:Ni. It was attributed to defects of oxygen vacancies (VO), zinc vacancies (VZn), zinc interstitials (Zni), oxygen interstitials (Oi), and oxygen vacancies complex (VO complex) in the structure of the film. The incorporation of Ni atoms in the ZnO structure stresses the crystal lattice, leaving behind a large number of surface defects that increase the emission of PL.

Published
2021
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16. Effect of the Deposit Temperature of ZnO Doped with Ni by HFCVD

Author

Delfino R. Gutiérrez, Godofredo García-Salgado, Antonio Coyopol, Enrique Rosendo-Andrés, Román Romano, Crisóforo Morales, Alfredo Benítez, Francisco Severiano, Ana María Herrera, and Francisco Ramírez-González

Subjects
HFCVD technique, nickel, dopant, zinc oxide, temperature, General Materials Science
Abstract

The effect of the deposit temperature of zinc oxide (ZnO) doped with nickel (Ni) by hot filament chemical vapor deposition (HFCVD) technique is reported in this work. The technique allows depositing ZnO:Ni in short intervals (1 min). A deposit of undoped ZnO is used as a reference sample. The reference sample was deposited at 500 °C. The ZnO:Ni samples were deposited at 500 °C, 400 °C, 350 °C, and 300 °C. The samples were studied using structural, morphological, and optical characterization techniques. The Ni incorporation to the ZnO lattice was verified by the shift of the X-ray diffraction peaks, the Raman peaks, the band gap, and the photoluminescence measurements. It was found that the deposit temperature affects the structural, morphological, and optical properties of the ZnO:Ni samples too. The structure of the ZnO:Ni samples corresponds to the hexagonal structure. Different microstructures shapes such as spheres, sea urchins, and agglomerate were found in samples; their change is attributed to the deposit temperature variation. The intensity of the photoluminescence of the ZnO:Ni improves concerning the ZnO due to the Ni incorporation, but it decreases as the deposit temperature decreases.

Published
2023
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19. Photoluminescent Enhancement by Effect of Incorporation Nickel in ZnO Films Grown

Author

Gutiérrez, Delfino R., primary, Díaz-Becerril, Tomás, additional, García-Salgado, Godofredo, additional, Coyopol-Solís, Antonio, additional, Rosendo-Andrés, Enrique, additional, Galeazzi-Isasmendi, Reina, additional, Peña-Sierra, Ramón, additional, Morales-Ruiz, Crisóforo, additional, Romano-Trujillo, Roman, additional, and Nieto-Caballero, Fabiola G., additional

Published
2021
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21. Photoluminescent Enhancement by Effect of Incorporation Nickel in ZnO Films Grown

Author

Gutiérrez, Delfino R., Díaz-Becerril, Tomás, García-Salgado, Godofredo, Coyopol-Solís, Antonio, Rosendo-Andrés, Enrique, Galeazzi-Isasmendi, Reina, Peña-Sierra, Ramón, Morales-Ruiz, Crisóforo, Romano-Trujillo, Roman, Nieto-Caballero, Fabiola G., Gutiérrez, Delfino R., Díaz-Becerril, Tomás, García-Salgado, Godofredo, Coyopol-Solís, Antonio, Rosendo-Andrés, Enrique, Galeazzi-Isasmendi, Reina, Peña-Sierra, Ramón, Morales-Ruiz, Crisóforo, Romano-Trujillo, Roman, and Nieto-Caballero, Fabiola G.

Abstract

Microstructured films of undoped zinc oxide (ZnO) and ZnO doped with nickel (ZnO:Ni) were grown by hot filament chemical vapor deposition (HFCVD) technique on Si (100) substrates at 500 °C. Pellets of ZnO and ZnO:NiO as oxidant agenst were used. A shift to the right around 0.17 degree of the X-Ray Diffraction pattern of the ZnO:Ni film was observed with respect to undoped ZnO films. Morphologically by Scanning Electron Microscopy was noticed a Core-Shell type growth in ZnO undoped and a nanostructured type (Nano-wire) in ZnO doped with Ni. Photoluminescence measurements showed an increase in the intensity of the green emission band of ZnO:Ni. It was attributed to defects of oxygen vacancies (VO), zinc vacancies (VZn), zinc interstitials (Zni), oxygen interstitials (Oi), and oxygen vacancies complex (VO complex) in the structure of the film. The incorporation of Ni atoms in the ZnO structure stresses the crystal lattice, leaving behind a large number of surface defects that increase the emission of PL.

Published
2021

28. Long-Term Use of Ticagrelor in Patients with Prior Myocardial Infarction

Author

Bonaca, MP, Bhatt, DL, Cohen, M, Steg, PG, Storey, RF, Jensen, EC, Magnani, G, Bansilal, S, Fish, MP, Im, K, Bengtsson, O, Ophuis, TO, Budaj, A, Theroux, P, Ruda, M, Hamm, C, Goto, S, Spinar, J, Nicolau, JC, Kiss, RG, Murphy, SA, Wiviott, SD, Held, P, Braunwald, E, Sabatine, MS, Morin, S, Dantzer, E, Acquilano, D, McGuire, RL, Gannon, JB, Gershman, E, Ahlbom, AM, Boberg, B, Abola, MT, Ardissino, D, Aylward, P, Corbalan, R, Dalby, A, Diaz, R, Hu, DY, Isaza, D, Kamensky, G, Kiss, R, Kontny, F, Lopez-Sendon, J, Medina, F, Montalescot, G, Nicolau, J, Paolasso, E, Parkhomenko, A, Van De Werf, F, Anderson, JL, White, HD, Verheugt, FWA, Pedersen, TR, DeMets, DL, Lowe, C, Arevalo, C, Awtry, E, Berger, C, Croce, K, Desai, A, Gelfand, E, Ho, C, Leeman, D, Link, M, Norden, A, Pande, A, Rost, N, Ruberg, F, Silverman, S, Singhal, A, Vita, J, Alvarisqueta, A, De Gennaro, N, Berli, M, Roude, AE, Di Gennaro, JA, Albisu, JF, Caccavo, A, Torres, M, Cuadrado, J, Bordoni, P, Cuello, J, Aviles, A, Glenny, A, Recoaro, R, Fernandez, R, Strada, BN, Fuentealba, V, Gallo, C, Duran, RG, Garcia, C, Hominal, M, Castoldi, M, Jure, H, Pacora, FF, Lorenzatti, A, Martinez, JM, Macin, S, Cocco, N, MacKinnon, I, Bagnato, MB, Marino, J, Cusimano, S, Arias, V, Focaccia, M, Muntaner, J, Mansilla, V, Poy, C, Prado, A, Paterlini, G, Montana, O, Camino, A, Sala, J, Luciani, C, Vico, M, Morell, Y, Dumont, C, Vottero, E, Zangroniz, P, Lescano, A, Morara, P, Marquez, LL, Patron, FR, Labarta, GB, Sivila, CD, Quiroga, AR, Maffei, L, Sassone, S, Rolandi, F, Vesentini, N, Carnero, G, Del Verme, S, Hershson, A, Figal, JC, Viso, ME, Hii, C, Smith, K, Singh, B, Acampo, M, Rogers, J, ODonoghue, M, Amerena, J, Long, A, Dart, A, Kay, S, Worthley, M, Nimmo, J, Lehman, R, Morrison, H, Dick, R, Savage, C, van Gaal, W, Park, M, Blombery, P, McCarthy, C, Oqueli, E, Hill, D, Sader, M, Vrachas, D, Purnell, P, Vibert, J, Collins, N, Gordon, A, Arstall, M, Rose, J, Aroney, C, Cleave, P, Fitzpatrick, M, Mackenzie, M, Garrahy, P, Hall, C, Nelson, G, Reid, E, Lee, A, Gibbs, J, Thompson, P, Crittenden, J, Hammett, C, Hindom, L, Antonis, P, Manzoney, A, Cross, D, Pollard, C, Brieger, D, Wu, J, Whelan, A, Tulloch, G, Taylor, A, Smith, B, Horowitz, J, Black, M, Boland, J, Malmendier, D, Celen, H, Wendelen, E, Claeys, M, Pieter, M, Cools, F, Simons, N, De Maeseneire, S, De Wolf, L, Brike, C, Dubois, P, Bolado, ACY, Foading-Deffo, B, Tahon, S, Friart, A, Arend, C, Gevaert, S, Verdegem, P, Marechal, P, Gits, F, Pierard, L, Celentano, C, Pirenne, B, Bouvy, C, Renkin, J, Huyberechts, D, Sinnaeve, P, De Velder, L, Stammen, F, Casier, T, Striekwold, H, Van den Broeck, D, Thoeng, J, Goris, R, Timmermans, P, Collard, SJ, Van De Borne, P, De Clippel, M, Wollaert, B, Jacobs, C, Vankelecom, B, Daelemans, Y, Vervoort, G, Drieghe, S, Vranckx, P, Janssen, A, Vrolix, M, Simenon, I, Wijns, W, Delacroix, H, Denie, D, Schoors, D, Lemoine, I, Cornelis, K, Willems, AM, Schroder, E, Domange, J, Greque, G, Machado, H, Armaganijan, D, Del Monaco, MI, da Silva, D, Nakazone, R, Dutra, O, Vaz, R, Daher, R, Rodrigues, D, Guimaraes, A, Teixeira, A, Saraiva, J, Leaes, P, Blacher, M, Maia, L, Nakazone, MA, Manenti, E, Ruschel, K, Marin-Neto, J, Pavao, R, Preto, R, Junior, AA, Oliveira, G, Rassi, S, Sampaio, D, Rossi, PR, dos Santos, L, de Souza, J, Lino, E, Filho, PP, Zucchetti, C, Gomes, M, de Paiva, A, Sousa, AC, Almeida, A, Botelho, R, da Silva, R, Giraldez, R, Franken, M, Faludi, A, Bertolami, M, Hernandes, M, Lucas, N, Carvalho, A, Bertolami, A, Precoma, D, Geralde, L, Pereira, A, Cesar, L, Mioto, B, Marino, R, Rabelo, W, dos Santos, F, Vidotti, M, Mangione, J, Mauro, M, Kormann, A, Ultramari, F, Zimmermann, S, Michalaros, Y, Fonseca, M, Sampaio, C, Eliaschewitz, F, Barbosa, E, Drews, C, de Lorenzo, A, Barros, C, Cancado, G, Neuesnchwander, F, Zimmermann, E, Chompalova, B, Denchev, S, Gocheva, N, Mihov, A, Mincheva, V, Gelev, V, Tisheva, S, Todorov, G, Goudev, A, Parvanova, Z, Todorova, M, Mitkova, M, Smilov, L, Yakovova, S, Milanova, K, Aleksov, N, Mollov, M, Shishmanova, D, Hristova, K, Uzunangelov, Y, Peltegov, V, Karamitev, G, Benov, H, Vasileva, D, Parishev, G, Milcheva, N, Avramov, D, Miteva, B, Stoyanovski, V, Pencheva, G, Nikolova, L, Stancheva, N, Nyagina, M, Markov, D, Spirova, D, Peneva, Y, Peshkov, O, Mitkova, L, Mandzhukova, S, Rangelova, V, Ivanov, K, Krusheva, B, Raycheva, V, Gergova, V, Goranov, K, Stoykov, A, Staleva, M, Rashkova, V, Postadzhian, A, Krancheva, V, Lulova, E, Delchev, G, Cantor, W, Constance, C, Gosselin, G, Marr, D, Pandey, A, Pesant, Y, Pouliot, J, Gladstone, P, McPherson, T, Rupka, D, Saw, J, St-Amour, E, Syan, G, Syan, R, Rosenbloom, A, Vizel, S, Della Siega, A, Halperin, F, Nigro, F, Chehayeb, R, Fell, D, Labonte, R, Nawaz, S, Gupta, M, Ma, P, Glanz, A, Kouz, S, Bhargava, R, Dion, D, Dupuis, R, Grondin, F, Wong, B, Sabbah, E, Hui, W, Belisle, P, Tymchak, W, Montigny, M, Lonn, E, Bose, S, Kincade, D, Gallo, R, Lamy, A, Bell, A, Lemay, M, Bata, I, Kostuk, W, Cheung, S, Petrella, R, Lubelsky, B, Berlingieri, J, Fortin, C, DeYoung, J, Babapulle, M, Landry, D, Gupta, A, Bertrand, O, Jadin, M, Robbins, K, Gauthier, MF, Masson, C, Reyes, V, O'Blenis, G, Clarus, S, Sardin, V, Marquette, S, Bozek, B, Spurrell, D, Thiessen, S, Fox, R, Tremblay, I, Singh, J, Samms, S, Ross, B, Solomon, P, Nelson, S, Roberts, P, Forsyth, C, Lepage, C, McPherson, C, Dewar, C, Dela Cruz, C, Louch, D, Vilag, C, Roy, M, Stata, C, Morissette, A, Ouimet, F, Bilodeau, N, Chausse, I, Kvill, L, Chartrand, MJ, Harris, L, Bolduc, H, Magi, A, Jule, P, Valley, S, Morrissette, J, Power, P, Kailey, P, Thomas, A, Wright, D, Carr, S, Cleveland, T, Dihel, C, Coldwell, J, Schellenberg, S, Viau, C, Watt, M, Corke, R, Shea-Landry, G, Gandhi, A, Tishler, S, Prieto, JC, Noriega, V, Cobos, L, Obreque, C, Potthof, S, Zapata, J, Lucero, F, Luque, M, Pincetti, C, Torres, G, Yanez, M, Vasquez, C, Manriquez, L, Espinoza, MJ, Yovaniniz, P, Grandon, M, Castro, P, Llevaneras, S, Lanas, F, Hidalgo, J, 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Fielding, M, Doorey, A, Squire, A, Suresh, D, Frost, J, Teklinski, A, Stone, B, Waksman, R, Griffin, S, Wharton, W, Blakely, J, Fishbein, G, Weller, C, Camp, A, Fisher, S, Meholick, A, Hejna, E, Anderson, R, Long, S, Parikh, S, Norton, N, Vijay, N, Washam, M, Smith, S, and Stepanov, N

Abstract

BACKGROUND The potential benefit of dual antiplatelet therapy beyond 1 year after a myocardial infarction has not been established. We investigated the efficacy and safety of ticagrelor, a P2Y(12) receptor antagonist with established efficacy after an acute coronary syndrome, in this context. METHODS We randomly assigned, in a double-blind 1: 1: 1 fashion, 21,162 patients who had had a myocardial infarction 1 to 3 years earlier to ticagrelor at a dose of 90 mg twice daily, ticagrelor at a dose of 60 mg twice daily, or placebo. All the patients were to receive low-dose aspirin and were followed for a median of 33 months. The primary efficacy end point was the composite of cardiovascular death, myocardial infarction, or stroke. The primary safety end point was Thrombolysis in Myocardial Infarction (TIMI) major bleeding. RESULTS The two ticagrelor doses each reduced, as compared with placebo, the rate of the primary efficacy end point, with Kaplan-Meier rates at 3 years of 7.85% in the group that received 90 mg of ticagrelor twice daily, 7.77% in the group that received 60 mg of ticagrelor twice daily, and 9.04% in the placebo group (hazard ratio for 90 mg of ticagrelor vs. placebo, 0.85; 95% confidence interval [CI], 0.75 to 0.96; P = 0.008; hazard ratio for 60 mg of ticagrelor vs. placebo, 0.84; 95% CI, 0.74 to 0.95; P = 0.004). Rates of TIMI major bleeding were higher with ticagrelor (2.60% with 90 mg and 2.30% with 60 mg) than with placebo (1.06%) (P < 0.001 for each dose vs. placebo); the rates of intracranial hemorrhage or fatal bleeding in the three groups were 0.63%, 0.71%, and 0.60%, respectively. CONCLUSIONS In patients with a myocardial infarction more than 1 year previously, treatment with ticagrelor significantly reduced the risk of cardiovascular death, myocardial infarction, or stroke and increased the risk of major bleeding. (Funded by AstraZeneca; PEGASUS-TIMI 54 ClinicalTrials.gov number, NCT01225562.)

Published
2015

31. Hyperphosphorylation Maintenance Drives the Time-Course of G2-M Cell Cycle Arrest after Short Treatment with NAMI-A in KB Cells

Author

Bergamo, Alberta, Delfino, R, Casarsa, C, Sava, Gianni, Bergamo, Alberta, Delfino, R, Casarsa, C, and Sava, Gianni

Subjects
NAMI-A, Ruthenium, Cell cycle, Tumour
Abstract

We investigated the molecular events of the ruthenium complex NAMI-A (0.1 mM for 1 h) on cell cycle G2-M arrest in KB carcinoma cells. Flow cytometry analysis showed a progressive accumulation of cells in S phase at 16 h, and in G2-M phase at 20 h after the end of treatment. NAMI-A pre-mitotic stop to cell proliferation was due to the maintenance of the phosphorylated, inactive, form of Cdk1, caused by the activation of the ATM/ATR checkpoint, as confirmed by the up-regulation and phosphorylation of Chk1. All these events are related to intracellular ruthenium accumulation, as confirmed by the lack of similar effects in cell lines unable to take the ruthenium compound up. Considering the dependence of NAMI-A cell cycle arrest on the dose and on the length of cell challenge, and considering the prolonged NAMI-A t1/2 in vivo in the lungs, we proved an even greater perturbation of the cell cycle regulating pathways in lung metastases of NAMI-A treated mice. The ex-vivo data confirm the interaction of the ruthenium compound NAMI-A with the ATM/ATR pathway, leading to the modulation of cell cycle regulating proteins, that can break the metastases cell cycle progression off.

Published
2012

35. Hospital network for Risk Management: A functional model

Author

Rubba, F., Panico, S., Scafarto, M. V., Lauro, N., Brunetti, A., Trimarco, V., Caporale, O., Delfino, R., Cuccaro, P., Capone, D., Di Renzo, G., Maria Triassi, Rubba, F, Panico, Salvatore, Scafarto, M. V., Lauro, N., Brunetti, A., Trimarco, V., Caporale, O., Delfino, R., Cuccaro, P., Capone, D., Di Renzo, G., and Triassi, Maria

Subjects
Computer Networks and Communication, Artificial Intelligence, Information Systems
Published
2006

37. Heritability Estimates Of Lactation Traits In Maltese Goat

Author

Pesce Delfino, R., Maria Selvaggi, Celano, G. V., and Dario, C.

Subjects
Heritability estimate, lactation traits, Maltese goat
Abstract

Data on 657 lactation from 163 Maltese goat, collected over a 5-year period were analyzed by a mixed model to estimate the variance components for heritability. The considered lactation traits were: milk yield (MY) and lactation length (LL). Year, parity and type of birth (single or twin) were significant sources of variation for lactation length; on the other hand milk yield was significantly influenced only by the year. The average MY was 352.34 kg and the average LL was 230 days. Estimates of heritability were 0.21 and 0.15 for MY and LL respectively. These values suggest there is low correlation between genotype and phenotype so it may be difficult to evaluate animals directly on phenotype. So, the genetic improvement of this breed may be quite slow without the support of progeny test aimed to select Maltese breeders., {"references":["D. Carnicella, M. Dario, M. C. C. Ayres, V. Laudadio, C. Dario, \"The\neffect of diet, parity, year and number of kids on milk yield and milk\ncomposition in Maltese goat,\" Small Rum. Res. vol. 77, June 2008, pp.\n71-74.","SAS, 1999. SAS/STAT, User-s Guide, Version 8, (SAS Institute, Cary,\nNC).","W. A. Becker, \"Estimation of variance components and heritability\". in:\nManual of Procedures in Quantitative Genetics. 2nd ed. The Program in\nGenetics. Washington State University, Puyallup, WA, 1968, pp 7-59.","A. P. Mavrogenis, A. Constantinou and A. Louca, \"Environmental and\ngenetic causes of variation in production traits of Damascus goats. 2.\nGoat productivity,\". Anim. Prod. vol. 38, 1984, pp 99-104.","A. P. Mavrogenis, C. Papachristoforou, P. Lysandrides and A. Roushias,\n\"Environmental and genetic effects of udder characteristics and milk\nproduction in Damascus goats,\". Small Rum. Res. vol 2, July 1989, pp\n333-343.","D. Boichard, N. Bouloc, G. Ricordeau, A. Piacere and F. Barillet,\n\"Genetic parameters for first lactation dairy traits in the Alpine and\nSaanen goat breeds,\" Genet. Sel. Evol. vol 21, 1989 pp 205-215.","S. N. Kala and B. Prakash, 1990. \"Genetic and phenotypic parameters\nof milk yield and milk composition in two Indian goat breeds,\" Small\nRum. Res. vol 3, Sept 1990, pp. 475-484.","A. Rabasco, J. M. Serradilla, J. A. Padilla and A. Serrano, \"Genetic and\nnon-genetic sources of variation in yield and composition of milk in\nVerata goats,\" Small Rum. Res. vol 11, July 1993, pp 151-161.","P. M. Valencia, L. J. Dobler and S. I. Arbiza, \"Sources of environmental\nvariation affecting lactation and pre-weaning growth characteristics in\nSaanen goats,\" Cuban J. Agric. Sci. vol 36, 2002, pp. 117-122.\n[10] M. Valencia, J. Dobler and H. H. Montaldo, \"Genetic and phenotypic\nparameters for lactation traits in a flock of Saanen goats in Mexico,\"\nSmall Rum. Res. vol 68, Apr 2007, pp 318-322.\n[11] M. U. Iloeje and L. D. van Vleck, \"Genetics of dairy goats: A review,\" J.\nDairy Sci. vol 61, Nov 1978, pp 1521-1528.\n[12] M. Shelton, \"Reproduction and breeding of goats,\" J. Dairy Sci. vol 61,\nJuly 1978, pp 994-1010.\n[13] B. W. Kennedy, C. M. Finley and G. E. Bradford \"Phenotypic and\ngenetic relationships between reproduction and milk production in dairy\ngoats,\" J. Dairy Sci. vol 65, Dec 1982, pp 2373-2383.\n[14] A. Constantinou, R. Beuing and A. P. Mavrogenis, \"Genetic and\nphenotypic parameters for some reproduction and milk production\ncharacters of the Damascus goat,\" Z. Tierzuechtg. Zuechtgsbiol. vol\n102, 1985, pp 301-307.\n[15] B. P. Sullivan, B. W. Kennedy and L. R. Schaeffer, \"Heritabilities,\nrepeatabilities and correlations for milk, fat and protein yields in goats,\"\nJ. Dairy Sci. 69 (suppl. 1), 1986, p. 100.\n[16] A. Constantinou, \"Genetic and environmental relationships of body\nweight, milk yield and litter size in Damascus goats,\" Small Rum. Res.\nvol 2, July 1989, pp 163-174.\n[17] S. Bishop, B. Sullivan and L. R. Schaeffer, \"Genetic evaluation of\nCanadian dairy goats using test-day data,\" in: Milk and Beef Recording\nState of the Art, Proc. of the 29th Biennial Session of the International\nCommittee for Animal Recording, Ottawa, Canada, 1994, pp. 299-302.\n[18] S. Andonov, M. Kovac, D. Kompan and V. Dzabirski, \"Estimation of\ncovariance components for test day production in dairy goat,\" Proc. of\n6th World Cong. Genet. Appl. Livest. Prod., 1998, pp 145-148.\n[19] C. A. Morris, M. Wheeler and M. Lanuzel, (2006) \"Genetic trend and\nparameter estimates for milk yield traits and kidding date in a Saanen\ngoat herd in New Zealand\". N.Z. J. Agric. Res. vol 49, June 2006, pp\n175-181.\n[20] E. C. Pimenta Filho, J. L. R. Sarmento, M.N. Ribeiro, \"Efeitos genéticos\ne ambientais que afetam a produção de leite e duração da lactação de\ncabras ,esti├ºas no estado da Para├¡ba,\" Rev. Bras. Zootec. vol 31,\nNov/Dec, 2004 pp 1426-1431."]}

Published
2011
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38. X-ray fluorescence elemental mapping and microscopy to follow hepatic disposition of a Gd-based magnetic resonance imaging contrast agent

Author

Delfino, R., Altissimo, M., Menk, R. H., Alberti, R., Klatka, T., Frizzi, T., Longoni, A., Salomè, M., Tromba, G., Arfelli, Fulvia, Clai, M., Vaccari, L., Lorusso, V., Tiribelli, Claudio, Pascolo, L., R., Delfino, M., Altissimo, R. H., Menk, R., Alberti, T., Klatka, T., Frizzi, A., Longoni, M., Salomè, G., Tromba, Arfelli, Fulvia, M., Clai, L., Vaccari, V., Lorusso, Tiribelli, Claudio, and L., Pascolo

Subjects
Liver, Imaging, Iron, Contrast Media, Spectrometry, X-Ray Emission, Gadolinium, Magnetic Resonance Imaging, Hepatitis, Fatty Liver, Mice, Mice, Inbred CBA, Organometallic Compounds, Animals, Female
Abstract

1. Spatially resolved X-ray fluorescence (XRF) spectroscopy with synchrotron radiation is a technique that allows imaging and quantification of chemical elements in biological specimens with high sensitivity. In the present study, we applied XRF techniques at a macro and micro level to carry out drug distribution studies on ex vivo models to confirm the hepatobiliary disposition of the Gd-based magnetic resonance imaging contrast agent B22956/1. 2. Gd presence was selectively quantified allowing the determination of the time dependent disappearance of the drug from blood and its hepatic accumulation in mice after administration. Elemental mapping highlighted the drug distribution differences between healthy and diseased livers. XRF microanalyses showed that in CCl(4) -induced hepatitis, B22956/1 has greatly reduced hepatic accumulation, shown as a 20-fold reduction of Gd presence. Furthermore, a significant increase of Fe presence was found in steatotic compared with healthy livers, in line with the disease features. 3. The present results show that XRF might be useful in preclinical pharmacological studies with drugs containing exogenous elements. Furthermore, quantitative and high-sensitivity elemental mapping allows simultaneous detection of chemical variation, showing pathological conditions. This approach was useful in suggesting reduced B22956/1 accumulation in steatotic livers, thus opening possible new diagnostic perspectives for this drug.

Published
2011

42. Low Ankle-brachial index predicts an adverse 1-year outcome after acute coronary and cerebrovascular events

Author

Agnelli, G., Cimminiello, C., Meneghetti, G., Urbinati, S., Cappielo, E., Bazzi, P., Arpaia, G., Santamaria, M. G., Tassara, R. I., Rebuttato, A. I., Perna, G. P., Gabrielli, D., Ruga, O., Moretti, L., Gregori, G., Marconi, M. K., Burali, A., DE LUCA, I. M., Ciriello, N. M., Ciampa, G. N., Pitscheider, W., Tomaino, M., Poma, E., Poggio, G., Spissu, A., Melis, A., Pinna, L., Lastilla, M., Bonaventura, A. R., Visonà, A. S., Tonello, D. S., Pennisi, G., Bella, R, Santonocito, D., Borrello, G. U., Mazza, M. L., Mattoscio, N., Garzaro, L., Pinneri, F., Zarcone, D., Lanfranchi, S., Moretti, V., Busettini, G., Bordin, P., Delfino, R. Z., Zingarelli, A., Caroppo, E. A., Puccetti, I. A., Orlandi, M., Losi, L., DE CAROLIS, P., Zanini, R., Cionini, F., Viecca, M., Lazzaroni, A., Satta, T., Manenti, V., Basile, G., Tuccillo, B., Accadia, M., Piatto, A., Annunziata, L., Mandarini, A., Androne, V. A., Traccis, S. A., Ottina, M., D'Angelo, A., Fazio, M., Damiani, L. A., Lupo, I., Savettieri, G., DEL PINTO, M., Notaristefano, S., Imberti, D., Tartarin, G., Lucarini, A., Topi, A., D'Anna, S., Saccardi, M., Paciello, M. A., Tordini, G., D'Arienzo, E., Piovaccari, G., Pesaresi, A., Amabile, G., Fiermonte, G., Gallù, M. C., Fontana, L., Ferri, F., Curatola, L., Gobbato, R., Paci, C., Simone, P., DI VIESTI, P., Tonizzo, M., LI VOLSI, P., Gionco, M., Onofri, M., Scorzoni, D., Grimoldi, P., Dentali, F., Ageno, W., Venco, A., and Grillo, G.

Subjects
Male, Brachial Artery, Myocardial Infarction, Blood Pressure, Coronary Disease, Cohort Studies, Angina, Odds Ratio, Prospective Studies, Myocardial infarction, Transient ischemic attack, Prospective cohort study, Stroke, Acute myocardial infarction, Ankle-brachial index, Atherosclerosis, Unstable angina, Acute Disease, Aged, Angina, Unstable, Ankle, Cerebrovascular Disorders, Female, Follow-Up Studies, Hospitalization, Humans, Ischemic Attack, Transient, Italy, Predictive Value of Tests, Prognosis, Regression Analysis, Survival Analysis, Syndrome, Hematology, Ischemic Attack, Transient, Predictive value of tests, cardiovascular system, Cardiology, medicine.symptom, medicine.medical_specialty, Unstable, Asymptomatic, Internal medicine, medicine, cardiovascular diseases, business.industry, Odds ratio, medicine.disease, body regions, business, human activities
Abstract

Summary. Background: Low ankle–brachial Index (ABI) identifies patients with symptomatic and asymptomatic peripheral arterial disease. The aim of this study was to correlate ABI value (normal or low) with 1-year clinical outcome in patients hospitalized for acute coronary syndromes or cerebrovascular diseases (CVD). Methods: ABI was measured in consecutive patients hospitalized because of acute myocardial infarction, unstable angina, stroke or transient ischemic attack (TIA). An ABI lower than or equal to 0.90 was considered abnormal. The primary outcome of the study was the composite of non-fatal acute myocardial infarction, non-fatal ischemic stroke, and death from any cause during the year following the index event. Results: An abnormal ABI was found in 27.2% of 1003 patients with acute coronary syndromes, and in 33.5% of 755 patients with acute CVD. After a median follow-up of 372 days, the frequency of the primary outcome was 10.8% (57/526) in patients with abnormal ABI and 5.9% (73/1232) in patients with normal ABI [odds ratio (OR) 1.96; 95% CI 1.36–2.81]. Death was more common in patients with abnormal ABI (OR 2.05; 95% CI 1.31–3.22). Cardiovascular mortality accounted for 81.7% of overall mortality. ABI was predictive of adverse outcome after adjustment for vascular risk factors in the logistic regression analysis (OR 1.93; 95% CI 1.24–3.01). The predictive value of ABI was mainly accounted for by patients hospitalized for acute coronary syndromes (adverse outcome: 12.8% in patients with abnormal ABI and 5.9% in patients with normal ABI, OR 2.35; 95% CI 1.47–3.76). Conclusions: An abnormal ABI can be found in one-third of patients hospitalized for acute coronary or cerebrovascular events and is a predictor of an adverse 1-year outcome.

Published
2006

43. Sobre ferrocarriles, lagunas y lluvias: características de las pesquerías comerciales de pejerrey en la cuenca del río Salado (provincia de Buenos Aires)

Author

Baigún, Claudio Rafael Mariano and Delfino, R. L.

Subjects
Peces, Ciencias Naturales, pejerrey, pesca comercial, lagunas pampásicas, ferrocarriles, precipitaciones, Buenos Aires (Argentina)
Abstract

La variabilidad hidrológica en lagunas de la pampasia bonaerense es un hecho reconocido desde los tiempos de Florentino Ameghino. Sin embargo, poco se ha explorado como la dinámica hídrica de estos ambientes, directamente vinculada a las precipitaciones, ha estado vinculado al uso de los recursos pesqueros. Asimismo es reconocido que las pesquerías comerciales de pejerrey representaron una actividad de gran importancia durante gran parte del siglo XX. A partir de información histórica (1928-1978) sobre capturas comerciales embarcadas en estaciones correspondientes a los ferrocarriles Roca, San Martín, Sarmiento y Belgrano (incluyendo el inolvidable Midland!), se describen sus características más generales y se analiza su relación con los niveles de precipitación como variable sustitutiva de la superficie de los cuerpos de agua, en diferentes regiones (subcuencas) de la cuenca del Salado. Las mayores capturas en la cuenca provenían de las Encadenadas del Oeste y Encadenadas del Salado. Considerando el total de sitios de embarque se aprecia una elevada variabilidad para toda la cuenca que oscila entre el 10%-180%, estando la media próxima al 100 %. Los ambientes localizados próximos a la desembocadura del río Salado presentaron una menor variación respecto a aquellos situados en la región sudoeste, que poseen una conexión más indirecta con este curso de agua. Asimismo las capturas estuvieron positivamente asociadas con los niveles de lluvia en la mayoría de las subcuencas examinadas, pero con una desfase de 2-3 años. Dicha relación posee importantes implicancias para el manejo de los recursos pesqueros particularmente para la aplicación de medidas regulatorias. Se concluye que los ferrocarriles pampeanos, hoy virtualmente extinguidos, han jugado un papel preponderante en el desarrollo de las pesquerías comerciales del pejerrey hasta la primera mitad del siglo XX., Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) - Instituto de Limnología "Dr. Raul A. Ringuelet" (ILPLA)

Published
2003

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