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The multifactorial nature of Late Onset Alzheimer's Disease (LOAD), the AD form of major relevance on epidemiological and social aspects, has driven the original investigation by LC-MS and top-down proteomics approach of the protein repertoire of the brain tissue of TgCRND8 model mice fed with a diet deficient in B vitamins. The analysis of the acid-soluble fraction of brain tissue homogenates identified a list of proteins and peptides, proteoforms and PTMs. In order to disclose possible modulations, their relative quantification in wild type and AD model mice under both B vitamin deficient and control diets was performed. The levels of metallothionein III, guanine nucleotide-binding protein G(I)/G(S)/G(0) subunit gamma-2 and brain acid soluble protein 1 showed statistically significant alterations depending on genotype, diet or both effects, respectively. Particularly, metallothionein III exhibited increased levels in TgCRND8 mice under B vitamin deficient diet with respect to wild type mice under both diets. Brain acid soluble protein 1 showed the opposite, revealing decreased levels in all diet groups of AD model mice with respect to wild type mice in control diet. Lower levels of brain acid soluble protein 1 were also observed in wild type mice under deficiency of B vitamins. These results, besides contributing to increase the knowledge of AD at molecular level, give new suggestions for deeply investigating metallothionein III and brain acid soluble protein 1 in AD.

Hemophagocytic lymphohistiocytosis (HLH) is a rare syndrome that is often fatal despite treatment. It is caused by a dysregulation in natural killer T-cell function, resulting in activation and proliferation of histiocytes with uncontrolled hemophagocytosis and cytokines overproduction. The syndrome is characterized by fever, hepatosplenomegaly, cytopenias, liver dysfunction, and hyperferritinemia. HLH can be either primary, with a genetic aetiology, or secondary, associated with malignancies, autoimmune diseases, or infections. Zoonotic diseases are an important cause of HLH. Secondary HLH can delay the correct diagnosis of the zoonotic disease, and can contribute to an adverse outcome.

A submersible device launcher includes an external cage structure including at least a base, an overhead reinforcing member and a plurality of corner posts connecting the base to the overhead reinforcing member. A launcher barrel is mounted to the external cage structure, a half-wall is mounted to and braced against the base of the external cage structure at a peripheral edge thereof, and an impulse cylinder is mounted to the half wall for connection to the launcher barrel. A firing valve is anchored to the base of the external cage structure, a first support bench is mounted to a first corner post of the external cage structure, and an air flask is seated on the first support bench and held in a stationary position thereon by prong members extending upwardly from the first support bench and further attached to a corner post by a band member. An underwater junction box is mounted to another corner post of the external cage structure, and a display panel is remotely positioned above the water surface for operating the firing valve and monitoring depth pressure firing valve pressure, air flask pressure and impulse cylinder at-battery and firing positions.

A submersible device launcher includes an external cage structure including at least a base, an overhead reinforcing member and a plurality of corner posts connecting the base to the overhead reinforcing member. A launcher barrel is mounted to the external cage structure, a half-wall is mounted to and braced against the base of the external cage structure at a peripheral edge thereof, and an impulse cylinder is mounted to the half wall for connection to the launcher barrel. A firing valve is anchored to the base of the external cage structure, a first support bench is mounted to a first corner post of the external cage structure, and an air flask is seated on the first support bench and held in a stationary position thereon by prong members extending upwardly from the first support bench and further attached to a corner post by a band member. An underwater junction box is mounted to another corner post of the external cage structure, and a display panel is remotely positioned above the water surface for operating the firing valve and monitoring depth pressure firing valve pressure, air flask pressure and impulse cylinder at-battery and firing positions.