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7. Molecular Sciences Review Serotonin in Animal Cognition and Behavior

Author

Bacqué-Cazenave, Julien, Bharatiya, Rahul, Barrière, Grégory, Delbecque, Jean-Paul, Bouguiyoud, Nouhaila, Giovanni, Giuseppe, Cattaert, Daniel, De Deurwaerdère, Philippe, Institut de Neurosciences cognitives et intégratives d'Aquitaine (INCIA), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1-SFR Bordeaux Neurosciences-Centre National de la Recherche Scientifique (CNRS), Universita degli Studi di Cagliari [Cagliari], University of Malta [Malta], School of Biosciences [Cardiff], and Cardiff University

Subjects
serotonin receptor, locomotion, mood, animal phyla, impulsive/compulsive dimension, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], decision-making, aggressiveness, anxiety, neuronal excitability, feeding
Abstract

International audience; Serotonin (5-hydroxytryptamine, 5-HT) is acknowledged as a major neuromodulator of nervous systems in both invertebrates and vertebrates. It has been proposed for several decades that it impacts animal cognition and behavior. In spite of a completely distinct organization of the 5-HT systems across the animal kingdom, several lines of evidence suggest that the influences of 5-HT on behavior and cognition are evolutionary conserved. In this review, we have selected some behaviors classically evoked when addressing the roles of 5-HT on nervous system functions. In particular, we focus on the motor activity, arousal, sleep and circadian rhythm, feeding, social interactions and aggressiveness, anxiety, mood, learning and memory, or impulsive/compulsive dimension and behavioral flexibility. The roles of 5-HT, illustrated in both invertebrates and vertebrates, show that it is more able to potentiate or mitigate the neuronal responses necessary for the fine-tuning of most behaviors, rather than to trigger or halt a specific behavior. 5-HT is, therefore, the prototypical neuromodulator fundamentally involved in the adaptation of all organisms across the animal kingdom.

Published
2020
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8. Serotonin in Animal Cognition and Behavior

Author

Bacqué-Cazenave, Julien, primary, Bharatiya, Rahul, additional, Barrière, Grégory, additional, Delbecque, Jean-Paul, additional, Bouguiyoud, Nouhaila, additional, Di Giovanni, Giuseppe, additional, Cattaert, Daniel, additional, and De Deurwaerdère, Philippe, additional

Published
2020
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15. Neuroendocrine disruption in the shore crab Carcinus maenas: Effects of serotonin and fluoxetine on chh- and mih-gene expression, glycaemia and ecdysteroid levels

Author

Le Foll, Frank, Robert, Alexandrine, Monsinjon, Tiphaine, Delbecque, Jean-Paul, Olivier, Stéphanie, Poret, Agnès, Foll, Frank Le, Durand, Fabrice, Knigge, Thomas, Sciences Appliquées à L'Environnement (SCALE), Université Le Havre Normandie (ULH), Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS), Stress Environnementaux et BIOsurveillance des milieux aquatiques (SEBIO), Normandie Université (NU)-Normandie Université (NU)-Université de Reims Champagne-Ardenne (URCA)-SFR Condorcet, Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS)-Institut National de l'Environnement Industriel et des Risques (INERIS), Centre de Neurosciences Intégratives et Cognitives, Université de Bordeaux (UB), Institut National de l'Environnement Industriel et des Risques (INERIS)-Université de Reims Champagne-Ardenne (URCA)-Université Le Havre Normandie (ULH), Normandie Université (NU)-Normandie Université (NU)-SFR Condorcet, Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS), and Normandie Université (NU)

Subjects
0301 basic medicine, medicine.medical_specialty, Serotonin, Invertebrate Hormones, Brachyura, Health, Toxicology and Mutagenesis, Nerve Tissue Proteins, [SDV.BC.BC]Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC], 010501 environmental sciences, Aquatic Science, Biology, Serotonergic, 01 natural sciences, Arthropod Proteins, 03 medical and health sciences, chemistry.chemical_compound, Internal medicine, Fluoxetine, Hemolymph, [SDV.BA.ZV]Life Sciences [q-bio]/Animal biology/Vertebrate Zoology, [SDV.BC.IC]Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB], medicine, Animals, Neurotransmitter, 5-HT receptor, ComputingMilieux_MISCELLANEOUS, 0105 earth and related environmental sciences, [SDV.EE]Life Sciences [q-bio]/Ecology, environment, Ecdysteroid, fungi, Ecdysteroids, Neurosecretory Systems, [SDV.BA.ZI]Life Sciences [q-bio]/Animal biology/Invertebrate Zoology, 030104 developmental biology, Endocrinology, chemistry, Gene Expression Regulation, Invertebrate hormone, [SDV.TOX.ECO]Life Sciences [q-bio]/Toxicology/Ecotoxicology, hormones, hormone substitutes, and hormone antagonists, Water Pollutants, Chemical, medicine.drug, Hormone
Abstract

Serotonin, a highly conserved neurotransmitter, controls many biological functions in vertebrates, but also in invertebrates. Selective serotonin reuptake inhibitors (SSRIs), such as fluoxetine, are commonly used in human medication to ease depression by affecting serotonin levels. Their residues and metabolites can be detected in the aquatic environment and its biota. They may also alter serotonin levels in aquatic invertebrates, thereby perturbing physiological functions. To investigate whether such perturbations can indeed be expected, shore crabs (Carcinus maenas) were injected either with serotonin, fluoxetine or a combination of both. Dose-dependent effects of fluoxetine ranging from 250 to 750nM were investigated. Gene expression of crustacean hyperglycemic hormone (chh) as well as moult inhibiting hormone (mih) was assessed by RT-qPCR at 2h and 12h after injection. Glucose and ecdysteroid levels in the haemolymph were monitored in regular intervals until 12h. Serotonin led to a rapid increase of chh and mih expression. On the contrary, fluoxetine only affected chh and mih expression after several hours, but kept expression levels significantly elevated. Correspondingly, serotonin rapidly increased glycaemia, which returned to normal or below normal levels after 12h. Fluoxetine, however, resulted in a persistent low-level increase of glycaemia, notably during the period when negative feedback regulation reduced glycaemia in the serotonin treated animals. Ecdysteroid levels were significantly decreased by serotonin and fluoxetine, with the latter showing less pronounced and less rapid, but longer lasting effects. Impacts of fluoxetine on glycaemia and ecdysteroids were mostly observed at higher doses (500 and 750nM) and affected principally the response dynamics, but not the amplitude of glycaemia and ecdysteroid-levels. These results suggest that psychoactive drugs are able to disrupt neuroendocrine control in decapod crustaceans, as they interfere with the normal regulation of the serotonergic system.

Published
2015
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24. Biosynthèse des stérols chez Chenopodium album et Serratula tinctoria: deux plantes produisant des ecdystéroïdes

Author

Corio-Costet, Marie-France, Chapuis, Lydie, Delbecque, Jean-Paul, ProdInra, Migration, Phytopharmacie et Biochimie des Iteractions Cellulaires (PBIC), Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB)-Etablissement National d'Enseignement Supérieur Agronomique de Dijon (ENESAD), and Université Bourgogne Franche-Comté [COMUE] (UBFC)

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
1992

26. 16thInternational Ecdysone Workshop: July 10–14, 2006, Ghent University, Belgium

Author

Bellés, Xavier, primary, Billas, Isabelle, additional, Cherbas, Peter, additional, Delbecque, Jean-Paul, additional, Dhadialla, Tarlochan, additional, Fujiwara, Haruchiko, additional, Hill, Ronald, additional, Hiruma, Kiyoshi, additional, Hermann, R, additional, Iatrou, Kostas, additional, Koolman, Jan, additional, Lafont, René, additional, Lepesant, Jean-Antoine, additional, Nakagawa, Yoshiaki, additional, Palli, Reddy, additional, Raikhel, Alexander, additional, Riddiford, Lynn, additional, Rees, Huw, additional, Sehnal, Frantisek, additional, Slama, Karl, additional, Smagghe, Guy, additional, Spindler, Kluas-Dieter, additional, Steel, Colin, additional, Swevers, Luc, additional, and Thummel, Carl, additional

Published
2007
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27. Serotonin, but not dopamine, controls the stress response and anxiety-like behavior in the crayfish Procambarus clarkii.

Author

Fossat, Pascal, Bacqueé-Cazenave, Julien, De Deurwaerde`re, Philippe, Cattaert, Daniel, and Delbecque, Jean-Paul

Subjects
PROCAMBARUS clarkii, SEROTONIN, PHYSIOLOGICAL stress, BRAIN physiology, BIOGENIC amines, BEHAVIOR, CRUSTACEA
Abstract

In the animal kingdom, biogenic amines are widespread modulators of the nervous system that frequently interact to control mood. Our previous investigations in crayfish (Procambarus clarkii) have established that stress induces changes in brain serotonin (5-HT) concentrations that are responsible for the appearance of anxiety-like behavior (ALB). Here, we further analyze the roles of 5-HT and another biogenic amine, dopamine (DA), on the crayfish response to stress. We show that the intensity of crayfish ALB depends on the intensity of stressful stimulation and is associated with increased concentrations of 5-HT in the brain. These 5-HT levels were significantly correlated, before, as well as after stress, with those of DA, which were approximately 3- to 5-times less abundant. However, whereas the degree of ALB was clearly correlated with brain 5-HT concentrations, it was not significantly correlated with DA. Moreover, in contrast to injections of 5-HT, DA injections were not able to elicit a stress response or ALB. In addition, 5-HT and DA levels were not modified by treatment with the anxiolytic chlordiazepoxide, confirming that suppression of ALB by this GABA-A receptor ligand acts downstream and is independent of changes in crayfish bioamine levels. Our study also provides evidence that the anxiogenic effect of 5-HT injections can be prevented by a preliminary injection of 5-HT antagonists. Altogether, our results emphasize that the rises in brain concentrations of 5-HT, but not DA, play a role in controlling the induction and the intensity of crayfish ALB. [ABSTRACT FROM AUTHOR]

Published
2015
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28. Sterol profiles of Serratula tinctoria, a plant producing ecdysteroids: plant and cell cultures

Author

Corio-Costet, Marie-France, Chapuis, LYDIE, Malosse, Christian, SCALLA, René, Delbecque, Jean-Paul, ProdInra, Migration, Phytopharmacie et Biochimie des Iteractions Cellulaires (PBIC), Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB)-Etablissement National d'Enseignement Supérieur Agronomique de Dijon (ENESAD), Unité de phytopharmacie et médiateurs chimiques, Institut National de la Recherche Agronomique (INRA), and Université Bourgogne Franche-Comté [COMUE] (UBFC)

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
1991

39. Control of motor activity in crayfish by the steroid hormone 20-hydroxyecdysone via motoneuron excitability and sensory-motor integration.

Author

Bacqué-Cazenave, Julien, Bouvet, Flora, Fossat, Pascal, Cattaert, Daniel, and Delbecque, Jean Paul

Subjects
CRAYFISH, STEROID hormones, ECDYSONE, AFFERENT pathways, MOTOR neurons, NEURAL circuitry
Abstract

We studied the effects of the molting hormone 20-hydroxyecdysone (20E) on leg sensory-motor networks of the red swamp crayfish, Procambarus clarkii. The hormone was injected in isolated crayfish and network activity was analyzed 3 days after injection using electrophysiology on an in vitro preparation of the leg locomotor network. This 20E treatment deeply reduced motor activity, by affecting both intrinsic motoneuron (MN) properties and sensory-motor integration. Indeed, we noticed a general decrease in motor nerve tonic activities, principally in depressor and promotor nerves. Moreover, intracellular recordings of depressor MNs confirmed a decrease of MN excitability due to a drop in input resistance. In parallel, sensory inputs originating from a proprioceptor, which codes joint movements controlled by these MNs, were also reduced. The shape of excitatory post-synaptic potentials (PSPs) triggered in MNs by sensory activity of this proprioceptor showed a reduction of polysynaptic components, whereas inhibitory PSPs were suppressed, demonstrating that 20E acted also on interneurons relaying sensory to motor inputs. Consequently, 20E injection modified the whole sensory-motor loop, as demonstrated by the alteration of the resistance reflex amplitude. These locomotor network changes induced by 20E were consistent with the decrease of locomotion observed in a behavioral test. In summary, 20E controls locomotion during crayfish premolt by acting on both MN excitability and sensory-motor integration. Among these cooperative effects, the drop of input resistance of MNs seems to be mostly responsible for the reduction of motor activity. [ABSTRACT FROM AUTHOR]

Published
2013
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45. The Drosophila disembodied gene controls late embryonic morphogenesis and codes for a cytochrome P450 enzyme that regulates embryonic ecdysone levels

Author

Chávez, V. Marcela, Marqués, Guillermo, Delbecque, Jean Paul, Kobayashi, Kayta, Hollingsworth, Margarita, Burr, John, Natzle, Jeanette E., and O’Connor, Michael B.

Abstract

Ecdysteroids regulate a wide variety of cellular processes during arthropod development, yet little is known about the genes involved in the biosynthesis of these hormones. Previous studies have suggested that production of 20-hydroxyecdysone in Drosophila and other arthropods involves a series of cytochrome P450 catalyzed hydroxylations of cholesterol. In this report, we show that the disembodied (dib) locus of Drosophila codes for a P450-like sequence. In addition, we find that dib mutant embryos have very low titers of ecdysone and 20-hydroxyecdysone (20E) and fail to express IMP-E1 and L1, two 20E-inducible genes, in certain tissues of the embryo. In situ hybridization studies reveal that dib is expressed in a complex pattern in the early embryo, which eventually gives way to restricted expression in the prothoracic portion of the ring gland. In larval and adult tissues, dib expression is observed in the prothoracic gland and follicle cells of the ovaries respectively, two tissues known to synthesize ecdysteroids. Phenotypic analysis reveals that dib mutant embryos produce little or no cuticle and exhibit severe defects in many late morphogenetic processes such as head involution, dorsal closure and gut development. In addition, we examined the phenotypes of several other mutants that produce defective embryonic cuticles. Like dib, mutations in the spook (spo) locus result in low embryonic ecdysteroid titers, severe late embryonic morphological defects, and a failure to induce IMP-E1. From these data, we conclude that dib and spo likely code for essential components in the ecdysone biosynthetic pathway and that ecdysteroids regulate many late embryonic morphogenetic processes such as cell movement and cuticle deposition.

Published
2000
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46. Efficacy of hexaflumuron against the fungus-growing termite Pseudacanthotermes spiniger (Sjöstedt) (isoptera, macrotermitinae)

Author

Peppuy, Alexis, Robert, Alain, Delbecque, Jean-Paul, Leca, Jean-Louis, Rouland, Corinne, and Bordereau, Christian

Abstract

The efficacy of hexaflumuron, a benzophenylurea insecticide, has been studied for the first time on a fungus-growing termite (Pseudacanthotermes spiniger Sjöstedt, Macrotermitinae). Results show that hexaflumuron could be useful in treating infestations of such pest species, which are of great economic importance in many tropical and equatorial countries. Foraging workers harvested and introduced treated food into the nest and subsequently contaminated the brood by trophallaxis. Hexaflumuron showed potent larvicidal activity. The compound did not appear to be rapidly degraded by the digestive enzymes of termite workers, nor by the symbiotic fungus Termitomyces eurhizus Heim growing on fungus combs. This chitin synthesis inhibitor did not act as a fungicide, since growth of the mycelium of this fungus was not inhibited in vitro. © 1998 Society of Chemical Industry

Published
1998

47. Ecdysteroid Titres during Autonomous Metamorphosis in a Dermestid Beetle

Author

Delbecque, Jean-Paul and Sláma, Karel

Abstract

The larvae of Dermestes maculatus are able to undergo several moults in complete absence of the cephalic and prothoracic neuroendocrine system, showing thus spontaneous metamorphosis. Measurements of ecdysteroid contents by radioimmunoassay methods have revealed distinctive larval, prepupal and pupal ecdysteroid peaks, as found in other species where development requires frequent stimulation by the centrally produced hormones. Mass fragmentographic analysis has indicated that more than 80% of the ecdysteroids detected by the radioimmunoassay during the peaks consists of ecdysterone.

Published
1980
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48. Analysis of Hemolymph Ecdysteroids in the Female Earwig: Labidura riparia

Author

VANCASSEL, MICHEL, FORASTE, MARYVONNE, STRAMBI, COLETE, STRAMBI, ALAIN, and DELBECQUE, JEAN-PAUL

Abstract

The nature of hemolymph ecdysteroids was analyzed by high performance liquid chromatography-radioimmunoassay, during the two main phases of the reproductive cycles of Labidura riparia. 20-hydroxyecdysone and ecdysone were present together with polar and apoiar products.Changes in the ecdysone/20-hydroxyecdysone ratio were evidenced according to the ovarian development. During natural (feeding and sexual phase of the cycle) or induced ovarian development, an increase of the ratio occurred whereas, during ovarian rest (fasting and/or parental phase), a significant decrease was observed.Up to 40 days after ovariectomy, immunoreactive compounds were observed in the hemolymph which corresponded partly to 20-hydroxyecdysone, ecdysone, and apoiar products. However, a large increase was observed in the proportions of the polar products which were mainly resolved, on the action of Helix enzymes, into 20-hydroxyecdysone and ecdysone.

Published
1991
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