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Recurrent respiratory papillomatosis (RRP) is a currently incurable benign neoplasm caused by human papilloma virus (HPV) infection. It usually reduces voice, respiratory, and general quality of life, and is sometimes life-threatening. Patients usually need repeated operations. The use of adjuvant bevacizumab, a monoclonal antibody targeting vascular endothelial growth factor A, has been described in several case reports, with a good efficacy and safety profile. We report the cases of five patients with aggressive RRP who were treated with adjuvant systemic bevacizumab in a single Belgian tertiary center. A complete response was achieved in four patients after a median of 4.5 months, and a partial response in one. In all cases, the number of surgeries was drastically reduced, and quality of life improved. Toxicity was easily managed. Systemic bevacizumab seems to be an effective and safe adjuvant treatment for aggressive RRP.

Spasmodic dysphonia (SD) or laryngeal dystonia is as a rare vocal disorder characterized by involuntary action-induced endolaryngeal contraction. In the last decade, botulin toxin injection has become the standard treatment in adductor spasmodic dysphonia necessitating repetitive injections. The purpose of this study is to analyze retrospectively data from patients treated with the minimal-invasive transoral radiofrequency-induced thermotherapy (RFITT) of the terminal branches of the recurrent nerve. Between 2009 and 2015, 11 patients (six females and five males aged from 32 to 91 years) with adductor SD were treated with RFITT. Pre-operative and post-operative vocal assessments (VHI-30, GRBASI, and acoustic-aerodynamics measurements), number of surgical revisions, delay between procedures, and post-operative complications were recorded. Statistical analyses were carried out on the first vocal assessment performed 2-8 weeks after the first procedure. Based on available data from ten patients, voice handicap index (VHI) showed improvement with a mean value of -17.7 points (p-value (pval) = 0.014, adjusted p-value (adj pval) = 0.21); instability has also revealed improvement in six patients (pval = 0.05, adj pval = 0.31). Four patients underwent only one procedure including one patient showing still long-term beneficial results after 5 years of follow-up. Other patients required one to three new procedures with an average time between procedures of 15.3 months. Over 24 surgeries performed on a total of 11 patients, one definitive treatment-related severe adverse event was reported. Thanks to long-lasting effect, repetitive treatments are less frequent compared to botulin toxin therapy. In our opinion, RFITT is a promising alternative to botulin toxin as a second-step procedure in case of toxin resistance or patient's lack of compliance.

Transoral Robotic Surgery (TORS) is an emerging technique for the treatment of head and neck tumors. The aim of this paper is to describe our experience of perioperative considerations. Indeed, TORS is feasible, safe, and both oncologically and functionally effective. However, this technology has certain perioperative implications. We present the experience of anesthesiologists and surgeons over the past ten years with the Da Vinci Surgical System, and strongly recommend assigning a specific medical and paramedical team to shorten the learning curve and manage this innovative surgical technique with confidence and expertise.

Objective: Medialization thyroplasty using the Montgomery® Implant System (MTIS) is a surgical procedure for the treatment of persistent glottal gaps. In this study, we aimed to analyze postoperative vocal outcomes in patients suffering from unilateral vocal fold paralysis. Methods: A retrospective study was conducted on 30 patients undergoing MTIS medialization thyroplasty for unilateral vocal fold immobility. This series was selected from 68 patients operated on by the same technique between 2009 and 2018. Patients with missing data were excluded. The surgical procedure was performed under local anesthesia and sedation with peroperative fiberoptic examination. A complete vocal assessment was undertaken pre- and postoperatively, including perceptual, aerodynamic, and acoustic parameters and a questionnaire. Shortterm outcomes were analyzed. Results: Postoperative assessment was performed at a median of 33 days (range eight to 216). Absolute median maximum phonation time showed an increase of 4.10 seconds (p < 0.05), whereas the voice handicap index decreased by 36 points (p < 0.05). No significant differences were found between sexes. Conclusion: This retrospective study confirms the excellent immediate vocal results after medialization thyroplasty using MTIS. Further studies with prospective data are needed to evaluate the results according to sex of the patient.

In this study, we report a rare case of herpetic infection of the larynx with vagus nerve palsy. Herpes simplex virus (HSV) and varicella zoster virus (VZV) are among the most common viral causes of vagus nerve (VN) dysfunction. The clinical presentation of herpetic laryngitis is variable. The diagnosis is clinical and can be confirmed by serological test or better yet by a PCR. When HSV or VZV infection is suspected, it is mandatory to start the antiviral treatment rapidly, within 72 hours. The use of corticosteroids remains a controversial subject. The consequences of vagus nerve damage are not negligible in terms of quality of life and may cause multiple symptoms due to the anatomical distribution of the nerve. Once the diagnosis is confirmed, intensive voice and swallowing rehabilitation must be undertaken to limit the functional impact and quality of life degradation.

BACKGROUND: When a patient is seen with a newly diagnosed oropharyngeal squamous cell carcinoma, it remains unclear to the treating physicians how fast the tumor growth rate is. METHODS: From patients with oropharynx squamous cell carcinoma treated by radiotherapy, the investigators selected comparable diagnostic CT-scan (DiCT) and radiotherapy planning CT-scan (RtCT). Tumor and pathological lymph node volumes were measured in order to calculate tumor progression. RESULTS: From the selection of 19 patients, the mean absolute tumor progression rate was 0.23 ± 0.2 cm3 /d and mean relative progression rate was 1.84 ± 1.64%/d. Mean tumor doubling time is 286 days (range 7-1282 days), demonstrating a wide range of tumor growth pattern. Significant tumor progression (>20%) between DiCT and RtCT was shown in 73% of patients, and 53% of the patients were seen a tumor progression of >50% within a mean waiting time of 42.1 days. Kaplan-Meier curves showed a non-significative link between fast progression tumors (>1%/d) and higher risk of recurrence (HR: 2.2; P = .23). CONCLUSIONS: Tumor progression can be assessed based on DiCT and RtCT. Treatment delay should be avoided at all cost. Different growth patterns were evidenced. For the fast-growing tumors subgroup, pejorative clinical outcomes were suggested. Prospective studies are needed to confirm a link between fast-growing tumors and higher risk for recurrence.

A 40-year-old man was admitted to the emergency room after a suicide attempt. He was found hanged in his garden shelter by a neighbour. The patient complained only of a slight dysphagia and anterior cervical pain. The clinical examination revealed no cutaneous lesion or neurological deficit. Head and neck CT scan with and without injection of contrast agent was performed. CT has shown displaced fractures of the two horns of the thyroïd cartilage (Figs. A, B; white arrow). Fractures were associated with a small tumefaction of the left hypopharyngeal soft tissue (Fig. C; white star) and left side of the larynx. The airways were patent. The ENT specialist achieved a laryngoscopy and confirmed the small buldging of the larynx, with no significant effect on the airways. Larynx mobility was conserved. A control fibroscopy was done 12 hours later with no modification of the lesions