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Hard magnetic materials are usually measured and used in an open magnetic circuit, for which demagnetizing effects are present. The applied field Ha has been conventionally corrected to the volume averaged internal field H by a formula H=Ha-NmM, where M is volume averaged magnetization and Nm is magnetometric demagnetizing factor calculated for the case of uniform magnetization as a function of body shape. Since Nm>0, such a correction always increases the slope of the descending M(Ha) curve without influencing the value of the coercive field with respect to M. However, we show by numerical calculations that if the hard magnetic material is granular and modeled as a rectangular prism, the magnetostatic interactions among the grains will result in a formula H=Ha-NghmM+ΔHc, where the demagnetizing factor for granular hard magnets Nghm can be either positive or negative and the usually positive coercivity increment ΔHc is correlated to collective magnetic reversal of longitudinal grain chains. [ABSTRACT FROM AUTHOR]

We present calculations of the alternating current (ac) susceptibility in rectangular thin-film type-II superconductors, based on the critical-state model and on the minimization of magnetic energy. First, we simulate a homogeneous superconductor and give an analytical approximate expression for both real and imaginary parts of the ac susceptibility as a function of the amplitude of the ac applied field. Second, ac susceptibility is calculated in a superconductor composed by two parts connected by a region of lower critical-current density. We find two peaks can appear in the imaginary ac susceptibility although, because of the strong demagnetizing fields, these peaks overlap in some cases. Detailed explanations of the imaginary part of the ac susceptibility are given. [ABSTRACT FROM AUTHOR]

The magnetic vortex formation at room temperature and its evolution under in-plane magnetic field is studied in chemically grown self-assembled La0.7Sr0.3MnO3 nanoislands of less than 200 nm in width. We use variable field magnetic force microscopy and numerical simulations to confirm that the vortex state is ubiquitous in these square-base pyramid shape epitaxial La0.7Sr0.3MnO3 nanostructures, and that it requires in-plane magnetic fields below 40 kA/m to be annihilated. [ABSTRACT FROM AUTHOR]

Skyrmions can be envisioned as bits of information that can be transported along nanoracetracks. However, temperature, defects, and/or granularity can produce diffusion, pinning, and, in general, modification in their dynamics. These effects may cause undesired errors in information transport. We present simulations of a realistic system where both the (room) temperature and sample granularity are taken into account. Key feasibility magnitudes, such as the success probability of a skyrmion traveling a given distance along the racetrack, are calculated. The results are evaluated in terms of the eventual loss of skyrmions by pinning, destruction at the edges, or excessive delay due to granularity. The model proposed is based on the Fokker-Planck equation resulting from Thiele's rigid model for skyrmions. The results could serve to establish error detection criteria and, in general, to discern the dynamics of skyrmions in realistic situations., Competing Interests: There are no conflicts of interest to declare., (This journal is © The Royal Society of Chemistry.)

Introduction and Objectives: Sudden cardiac death (SCD) in young people often has a genetic cause. Consequently, the results of "molecular autopsy" may have important implications for their relatives. Our objective was to evaluate the diagnostic yield of a molecular autopsy program using next-generation sequencing., Methods: We performed a prospective study of a cohort of consecutive patients who died from nonviolent SCD, aged ≤ 50 years, and who underwent molecular autopsy using large panels of next-generation sequencing, with subsequent clinical and genetic family screening. We analyzed demographic, clinical, toxicological, and genetic data., Results: We studied 123 consecutive cases of SCD in persons aged ≤ 50 years. The incidence of SCD was 5.8 cases/100 000 individuals/y, mean age was 36.15±12.7 years, and 95 were men (77%). The cause was cardiac in 53%, unexplained SCD in 24%, toxic in 10.6%, and infant SCD in 4%. Among cardiac causes, ischemic heart disease accounted for 38% of deaths, arrhythmogenic cardiomyopathy for 7%, hypertrophic cardiomyopathy for 5%, and idiopathic left ventricular hypertrophy for 11%. Genetic analysis was performed in 62 cases (50.4%). Genetic variants were found in 42 cases (67.7%), with a mean of 3.4±4 genetic variants/patient, and the variant found was considered to be pathogenic or probably pathogenic in 30.6%. In unexplained SCD, 70% showed some genetic variant. Family screening diagnosed 21 carriers or affected individuals, 5 of whom were at risk, indicating an implantable cardiac defibrillator., Conclusions: Protocol-based and exhaustive study of SCD from cardiac causes in persons aged ≤ 50 years is feasible and necessary. In a high percentage of cases, the cause is genetic, indicating the existence of relatives at risk who could benefit from early diagnosis and treatment to avoid complications., (Copyright © 2020 Sociedad Española de Cardiología. Published by Elsevier España, S.L.U. All rights reserved.)

Controlling magnetism, essential for a wide range of technologies, is impaired by the impossibility of generating a maximum of magnetic field in free space. Here, we propose a strategy based on negative permeability to overcome this stringent limitation. We experimentally demonstrate that an active magnetic metamaterial can emulate the field of a straight current wire at a distance. Our strategy leads to an unprecedented focusing of magnetic fields in empty space and enables the remote cancellation of magnetic sources, opening an avenue for manipulating magnetic fields in inaccessible regions.

Magnetic skyrmions are promising candidates as information carriers in spintronic devices. The transport of individual skyrmions in a fast and controlled way is a key issue in this field. Here we introduce a platform for accelerating, guiding and compressing skyrmions along predefined paths. The guiding mechanism is based on two parallel line defects (rails), one attractive and the other repulsive. Numerical simulations, using parameters from state-of-the-art experiments, show that the speed of the skyrmions along the rails can be increased up to an order of magnitude with respect to the non-defect case whereas the distance between rails can be as small as the initial radius of the skyrmions. In this way, the flux of information that can be coded and transported with magnetic skyrmions could be significantly increased.

Superconductors are essential in many present and future technologies, from large-scale devices for medical imaging, accelerators, or fusion experiments to ultra-low-power superconducting electronics. However, their potential applicability, and particularly that of high-temperature superconductors (HTS), is severely affected by limited performances at large magnetic fields and high temperatures, where their use is most needed. One of the main reasons for these limitations is the presence of quantized vortices, whose movements result in losses, internal noise, and reduced performances. The conventional strategy to overcome the flow of vortices is to pin them along artificial defects. Here, we theoretically and experimentally demonstrate that critical-current density in high-temperature superconductors can reach unprecedented high values at high fields and temperatures by preventing vortex entry. By tailoring the geometry, that is, reducing the width, W, of nanowire-patterned HTS films, the range of the Meissner state, for which no vortices are present, is extended up to very large applied field values, on the order of ∼1 T. Current densities on the order of the depairing current can be sustained under high fields for a wide range of temperatures. Results may be relevant both for devising new conductors carrying depairing-current values at high temperatures and large magnetic fields and for reducing flux noise in sensors and quantum systems.

Purpose: Amongst the epigenetically targeted therapies, targeting of the histone deacetylases (HDACs) has yielded numerous drugs for clinical use in hematological malignancies, but none as yet for acute lymphocytic leukemia (ALL). Single agent activity of HDAC inhibitors (HDACi) has been elusive in ALL, and has prompted study of combinatorial strategies. Because several HDACi raise levels of intracellular oxidative stress, we evaluated combinations of two structurally distinct HDACi with the redox active compound adaphostin in ALL., Methods: The HDACi vorinostat and entinostat were tested in combination with adaphostin in human ALL cell lines. DNA fragmentation, caspase activation, mitochondrial disruption and levels of  intracellular peroxides, superoxide and glutathione were measured in cells treated with the HDACi/adaphostin combinations. Antioxidant blockade of cell death induction and gene expression profiling of cells treated with vorinostat/adaphostin versus entinostat/adaphostin combinations were evaluated., Results: Both combinations synergistically induced apoptotic DNA fragmentation, which was preceded by an increase in superoxide levels, a reduction in mitochondrial membrane potential, and an increase in caspase-9 activation. The antioxidant N-acetylcysteine (NAC) blocked superoxide generation and prevented reduction of mitochondrial membrane potential. NAC decreased DNA fragmentation and caspase activity in cells treated with adaphostin and vorinostat, but not in those treated with adaphostin and entinostat. Gene expression arrays revealed differential regulation of several redox genes prior to cell death induction., Conclusions: A redox modulatory agent, adaphostin, enhances efficacy of two HDACi, vorinostat or entinostat, but via different mechanisms indicating a point of divergence in the mechanisms of synergy between the two distinct HDACi and adaphostin.

Superconductivity and ferromagnetism are two antagonistic phenomena that combined can lead to a rich phenomenology of interactions, resulting in novel physical properties and unique functionalities. Here we propose an original hybrid system formed by a high-temperature superconducting film, patterned with antidots, and with ferromagnetic nano-rods grown inside them. This particular structure exhibits the synergic influence of superconductor (SC) - ferromagnetic (FM) stray fields, in both the superconducting behaviour of the film and the three-dimensional (3D) magnetic structure of nano-rods. We show that FM stray fields directly influence the critical current density of the superconducting film. Additional functionalities appear due to the interaction of SC stray fields, associated to supercurrent loops, with the non-trivial 3D remanent magnetic structure of FM nano-rods. This work unravels the importance of addressing quantitatively the effect of stray magnetic fields from both, the superconductor and the ferromagnet in hybrid magnetic nano-devices based on high temperature superconductors.

Magnetic sensors are key elements in our interconnected smart society. Their sensitivity becomes essential for many applications in fields such as biomedicine, computer memories, geophysics, or space exploration. Here we present a universal way of increasing the sensitivity of magnetic sensors by surrounding them with a spherical metamaterial shell with specially designed anisotropic magnetic properties. We analytically demonstrate that the magnetic field in the sensing area is enhanced by our metamaterial shell by a known factor that depends on the shell radii ratio. When the applied field is non-uniform, as for dipolar magnetic field sources, field gradient is increased as well. A proof-of-concept experimental realization confirms the theoretical predictions. The metamaterial shell is also shown to concentrate time-dependent magnetic fields upto frequencies of 100 kHz.

A large manifold of nontrivial spin textures , including the stabilization of monopole-like fields , are generated by using a completely new and versatile approach based on the combination of superconductivity and magnetism. Robust, stable, and easily controllable complex spin structures are encoded, modified, and annihilated in a continuous magnetic thin film by defining a variety of magnetic states in superconducting dots.