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16,489 results on '"Del Giudice A."'

1. “Minimal-Advice” on Salt Intake: Results of a Multicentre Pilot Randomised Controlled Trial on Hypertensive Patients

Author

D’Elia, Lanfranco, Strazzullo, Pasquale, Del Giudice, Antonio, Desideri, Giovambattista, Di Quattro, Rosario, Ferri, Claudio, Grossi, Alessandra, Malatino, Lorenzo, Mallamaci, Francesca, Maresca, Andrea, Meschi, Michele, Casola, Alessia, Nazzaro, Pietro, Pappaccogli, Marco, Rabbia, Franco, Sala, Carla, and Galletti, Ferruccio

Published
2025
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3. Adjuvant Immune Checkpoint Inhibitors for Muscle-Invasive Urothelial Carcinoma: An Updated Systematic Review, Meta-analysis, and Network Meta-analysis: Adjuvant Immunotherapy for Urothelial Carcinoma

Author

Yanagisawa, Takafumi, Mori, Keiichiro, Matsukawa, Akihiro, Kawada, Tatsushi, Katayama, Satoshi, Laukhtina, Ekaterina, Rajwa, Pawel, Quhal, Fahad, Pradere, Benjamin, Fukuokaya, Wataru, Iwatani, Kosuke, Afferi, Luca, Marcq, Gautier, Mertens, Laura S., Gallioli, Andrea, Tully, Karl H., Caño-Velasco, Jorge, Subiela, José Daniel, Abu-Ghanem, Yasmin, Grobet-Jeandin, Elisabeth, Del Giudice, Francesco, Pichler, Renate, Teoh, Jeremy Yuen-Chun, Moschini, Marco, Krajewski, Wojciech, Miki, Jun, Shariat, Shahrokh F., and Kimura, Takahiro

Published
2025
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6. Monitoring Local and Global Properties of Collective Adaptive Systems

Author

Del Giudice, Nicola, Loreti, Michele, Quadrini, Michela, Rehman, Aniqa, Goos, Gerhard, Series Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, and Margaria, Tiziana, editor

Published
2025
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7. Long-term safety and effectiveness of a somatropin biosimilar (Omnitrope®) in children requiring growth hormone therapy: analysis of final data of Italian patients enrolled in the PATRO children study

Author

Iughetti, Lorenzo, Antoniazzi, Franco, Giavoli, Claudia, Bellone, Simonetta, Aversa, Tommaso, Guazzarotti, Laura, Street, Maria Elisabeth, Miraglia del Giudice, Emanuele, Persani, Luca, Pozzobon, Gabriella, Ragusa, Letizia, Stagi, Stefano, Tornese, Gianluca, Zecchino, Clara, Mameli, Chiara, Zecchi, Emiliano, Fedeli, Paolo, Zabransky, Markus, Lucaccioni, Laura, and Zucchini, Stefano

Published
2024
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9. Seeing eye to eye: a modified Delphi method-based multidisciplinary expert consensus on the diagnosis and treatment of vernal keratoconjunctivitis

Author

Ghiglioni, Daniele Giovanni, Bruschi, Gaia, Chiappini, Elena, Consales, Alessandra, Allegri, Pia, Aragona, Pasquale, Bonini, Stefano, Caputo, Roberto, Cardinale, Fabio, Landi, Massimo, Leonardi, Andrea, Marseglia, Gian Luigi, Mori, Francesca, Nebbioso, Marcella, Nucci, Paolo, Osnaghi, Silvia, Procoli, Ugo, Villani, Edoardo, Zicari, Anna Maria, and Miraglia Del Giudice, Michele

Published
2024
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14. Quantitative in vitro to in vivo extrapolation for human toxicology and drug development

Author

Cattelani, Luca, del Giudice, Giusy, Serra, Angela, Fratello, Michele, Saarimäki, Laura Aliisa, Fortino, Vittorio, Federico, Antonio, Tsiros, Periklis, Mannerström, Marika, Toimela, Tarja, Serchi, Tommaso, Lynch, Iseult, Doganis, Philip, Sarimveis, Haralambos, and Greco, Dario

Subjects
Quantitative Biology - Quantitative Methods
Abstract

Traditional animal testing for toxicity is expensive, time consuming, ethically questioned, sometimes inaccurate because of the necessity to extrapolate from animal to human, and in most cases not formally validated according to modern standards. This is driving regulatory bodies and companies in backing alternative methods focusing on in silico and in vitro approaches. These are complex to implement and validate, and their wide adoption is not yet established despite legal directives providing an imperative. It is difficult to link a cell level response to effects on a whole organism, but the advances in high-throughput toxicogenomics towards elucidating the mechanism of action of substances are gradually reducing this gap and fostering the adoption of Next Generation Safety Assessment approaches. Quantitative in vitro to in vivo extrapolation (QIVIVE) methods hold the promise to reveal how to use in vitro -omics data to predict the potential for in vivo toxicity. They could improve lead compounds prioritisation, reduce time and costs, also in numbers of animal lives, and help with the complexity of extrapolating between species. We provide a description of QIVIVE state of the art, including how the problems of dosing and timing are being approached, how in silico simulation can take into account the variability of individuals, and how multiple techniques can be integrated to face complex tasks like the prediction of long term toxicity, including a close look into the open problems and challenges ahead., Comment: We authors have decided to withdraw the preprint from arXiv at this time. This decision stems from our desire to revisit and refine certain specific points in our work

Published
2024

15. Hymenoptera venom allergy in children

Author

Giovannini, Mattia, Mori, Francesca, Barni, Simona, Saretta, Francesca, Arasi, Stefania, Castagnoli, Riccardo, Liotti, Lucia, Mastrorilli, Carla, Pecoraro, Luca, Caminiti, Lucia, Sturm, Gunter Johannes, Marseglia, Gian Luigi, del Giudice, Michele Miraglia, and Novembre, Elio

Published
2024
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18. The role of re-transurethral resection of bladder tumor in patients with TaHG non muscle invasive bladder cancer

Author

Scilipoti, Pietro, Moschini, Marco, de Angelis, Mario, Afferi, Luca, Lonati, Chiara, Longoni, Mattia, Tremolada, Giovanni, Zaurito, Paolo, Viti, Alessandro, Santangelo, Alfonso, Pichler, Renate, Necchi, Andrea, Montorsi, Francesco, Briganti, Alberto, Mari, Andrea, Krajewski, Wojciech, Laukthina, Ekaterina, Pradere, Benjamin, Del Giudice, Francesco, Mertens, Laura, Gallioli, Andrea, Soria, Francesco, Gontero, Paolo, Albisinni, Simone, Shariat, Shahrokh F., and Carando, Roberto

Published
2024
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21. Cardiometabolic risk in children and adolescents with obesity: a position paper of the Italian Society for Pediatric Endocrinology and Diabetology

Author

Valerio, Giuliana, Di Bonito, Procolo, Calcaterra, Valeria, Cherubini, Valentino, Corica, Domenico, De Sanctis, Luisa, Di Sessa, Anna, Faienza, Maria Felicia, Fornari, Elena, Iughetti, Lorenzo, Licenziati, Maria Rosaria, Manco, Melania, del Giudice, Emanuele Miraglia, Morandi, Anita, Salerno, Mariacarolina, Street, Maria Elisabeth, Umano, Giuseppina Rosaria, Wasniewska, Malgorzata, and Maffeis, Claudio

Published
2024
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25. Endothelial microRNAs in INOCA patients with diabetes mellitus

Author

Ferrone, Marco, Ciccarelli, Michele, Varzideh, Fahimeh, Kansakar, Urna, Guerra, Germano, Cerasuolo, Federica Andrea, Buonaiuto, Antonietta, Fiordelisi, Antonella, Venga, Enzo, Esposito, Mafalda, Rainone, Antonio, Ricciardi, Roberto, Del Giudice, Carmine, Minicucci, Fabio, Tesorio, Tullio, Visco, Valeria, Iaccarino, Guido, Gambardella, Jessica, Santulli, Gaetano, and Mone, Pasquale

Published
2024
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30. Fatal food anaphylaxis in adults and children

Author

Novembre, Elio, Gelsomino, Mariannita, Liotti, Lucia, Barni, Simona, Mori, Francesca, Giovannini, Mattia, Mastrorilli, Carla, Pecoraro, Luca, Saretta, Francesca, Castagnoli, Riccardo, Arasi, Stefania, Caminiti, Lucia, Klain, Angela, and del Giudice, Michele Miraglia

Published
2024
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31. Imported allergens in Italy: an emerging issue

Author

Pecoraro, Luca, Giovannini, Mattia, Mori, Francesca, Barni, Simona, Castagnoli, Riccardo, Arasi, Stefania, Mastrorilli, Carla, Saretta, Francesca, Liotti, Lucia, Caminiti, Lucia, Klain, Angela, Gelsomino, Mariannita, Del Giudice, Michele Miraglia, and Novembre, Elio

Published
2024
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32. Whole Genome Sequence Dataset of Mycobacterium tuberculosis Strains from Patients of Campania Region

Author

Folliero, Veronica, Ferravante, Carlo, Iovane, Valentina, Salvati, Annamaria, Crescenzo, Laura, Perna, Rossella, Corvino, Giusy, Della Rocca, Maria T., Panetta, Vittorio, Tranfa, Alessandro, Greco, Giuseppe, Baldoni, Teresa, Pagnini, Ugo, Finamore, Emiliana, Giurato, Giorgio, Nassa, Giovanni, Coppola, Mariagrazia, Atripaldi, Luigi, Greco, Rita, D’Argenio, Annamaria, Foti, Maria Grazia, Abate, Rosamaria, Del Giudice, Annalisa, Sarnelli, Bruno, Weisz, Alessandro, Iovane, Giuseppe, Pinto, Renato, Franci, Gianluigi, and Galdiero, Massimiliano

Published
2024
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37. CompSafeNano project: NanoInformatics approaches for safe-by-design nanomaterials

Author

Dimitrios Zouraris, Angelos Mavrogiorgis, Andreas Tsoumanis, Laura Aliisa Saarimäki, Giusy del Giudice, Antonio Federico, Angela Serra, Dario Greco, Ian Rouse, Julia Subbotina, Vladimir Lobaskin, Karolina Jagiello, Krzesimir Ciura, Beata Judzinska, Alicja Mikolajczyk, Anita Sosnowska, Tomasz Puzyn, Mary Gulumian, Victor Wepener, Diego S.T. Martinez, Romana Petry, Naouale El Yamani, Elise Rundén-Pran, Sivakumar Murugadoss, Sergey Shaposhnikov, Vasileios Minadakis, Periklis Tsiros, Harry Sarimveis, Eleonora Marta Longhin, Tanima SenGupta, Ann-Karin Hardie Olsen, Viera Skakalova, Peter Hutar, Maria Dusinska, Anastasios G. Papadiamantis, L. Cristiana Gheorghe, Katie Reilly, Emilie Brun, Sami Ullah, Sebastien Cambier, Tommaso Serchi, Kaido Tämm, Candida Lorusso, Francesco Dondero, Evangelos Melagrakis, Muhammad Moazam Fraz, Georgia Melagraki, Iseult Lynch, and Antreas Afantitis

Subjects
Computational approaches, nanomaterials safety, cloud platform, biomolecule interactions, nanoinformatics, Biotechnology, TP248.13-248.65
Abstract

The CompSafeNano project, a Research and Innovation Staff Exchange (RISE) project funded under the European Union's Horizon 2020 program, aims to advance the safety and innovation potential of nanomaterials (NMs) by integrating cutting-edge nanoinformatics, computational modelling, and predictive toxicology to enable design of safer NMs at the earliest stage of materials development. The project leverages Safe-by-Design (SbD) principles to ensure the development of inherently safer NMs, enhancing both regulatory compliance and international collaboration. By building on established nanoinformatics frameworks, such as those developed in the H2020-funded projects NanoSolveIT and NanoCommons, CompSafeNano addresses critical challenges in nanosafety through development and integration of innovative methodologies, including advanced in vitro models, in silico approaches including machine learning (ML) and artificial intelligence (AI)-driven predictive models and 1st-principles computational modelling of NMs properties, interactions and effects on living systems. Significant progress has been made in generating atomistic and quantum-mechanical descriptors for various NMs, evaluating their interactions with biological systems (from small molecules or metabolites, to proteins, cells, organisms, animals, humans and ecosystems), and in developing predictive models for NMs risk assessment. The CompSafeNano project has also focused on implementing and further standardising data reporting templates and enhancing data management practices, ensuring adherence to the FAIR (Findable, Accessible, Interoperable, Reusable) data principles. Despite challenges, such as limited regulatory acceptance of New Approach Methodologies (NAMs) currently, which has implications for predictive nanosafety assessment, CompSafeNano has successfully developed tools and models that are integral to the safety evaluation of NMs, and that enable the extensive datasets on NMs safety to be utilised for the re-design of NMs that are inherently safer, including through prediction of the acquired biomolecule coronas which provide the biological or environmental identities to NMs, promoting their sustainable use in diverse applications. Future efforts will concentrate on further refining these models, expanding the NanoPharos Database, and working with regulatory stakeholders thereby fostering the widespread adoption of SbD practices across the nanotechnology sector. CompSafeNano's integrative approach, multidisciplinary collaboration and extensive stakeholder engagement, position the project as a critical driver of innovation in NMs SbD methodologies and in the development and implementation of computational nanosafety.

Published
2025
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38. Methylation and transcriptomic profiling reveals short term and long term regulatory responses in polarized macrophages

Author

Giorgia Migliaccio, Jack Morikka, Giusy del Giudice, Maaret Vaani, Lena Möbus, Angela Serra, Antonio Federico, and Dario Greco

Subjects
Macrophage plasticity, Epigenetics, Long-term effect, Trained immunity, Multi-omics, Biotechnology, TP248.13-248.65
Abstract

Macrophage plasticity allows the adoption of distinct functional states in response to environmental cues. While unique transcriptomic profiles define these states, focusing solely on transcription neglects potential long-term effects. The investigation of epigenetic changes can be used to understand how temporary stimuli can result in lasting effects. Epigenetic alterations play an important role in the pathophysiology of macrophages, including their trained innate immunity, enabling faster and more efficient inflammatory responses upon subsequent encounters to the same pathogen or insult. In this study, we used a multi-omics approach to elucidate the interplay between gene expression and DNA-methylation, to explore the potential long-term effects of diverse polarizing environments on macrophage activity. We identified a common core set of genes that are differentially methylated regardless of exposure type, indicating a potential common fundamental mechanism for adaptation to various stimuli. Functional analysis revealed that processes requiring rapid responses displayed transcriptomic regulation, whereas functions critical for long-term adaptations exhibited co-regulation at both transcriptomic and epigenetic levels. Our study uncovers a novel set of genes linked to the long-term effects of macrophage polarization. This discovery underscores the potential of epigenetics in elucidating how macrophages establish long-term memory and influence health outcomes.

Published
2024
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39. Effects of daratumumab on hematopoietic stem cell collection and engraftment in multiple myeloma patients eligible for autologous transplantation: results of the real-life PRIMULA study comparing bortezomib, thalidomide and dexamethasone (VTd) with VTd plus daratumumab (D-VTd) as induction therapy

Author

Strafella, Vanda, Attolico, Immacolata, Carluccio, Paola, Tarantini, Francesco, Curci, Paola, Sgherza, Nicola, Rizzi, Rita, Ostuni, Angelo, Buda, Gabriele, Del Giudice, Maria Livia, Marasco, Vincenzo, Mele, Anna, Margiotta-Casaluci, Gloria, Valli, Viviana Beatrice, Mele, Giuseppe, Germano, Candida Rosaria, Quinto, Angela Maria, Palazzo, Giulia, Febbo, Massimiliano Arangio, Ciuffreda, Lucia, Reddiconto, Giovanni, Di Renzo, Nicola, Cimminiello, Michele, Albano, Francesco, and Musto, Pellegrino

Published
2024
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40. Correction to: Long-term safety and effectiveness of a somatropin biosimilar (Omnitrope®) in children requiring growth hormone therapy: analysis of final data of Italian patients enrolled in the PATRO children study

Author

Iughetti, Lorenzo, Antoniazzi, Franco, Giavoli, Claudia, Bellone, Simonetta, Aversa, Tommaso, Guazzarotti, Laura, Street, Maria Elisabeth, Miraglia del Giudice, Emanuele, Persani, Luca, Pozzobon, Gabriella, Ragusa, Letizia, Stagi, Stefano, Tornese, Gianluca, Zecchino, Clara, Mameli, Chiara, Zecchi, Emiliano, Fedeli, Paolo, Zabransky, Markus, Lucaccioni, Laura, and Zucchini, Stefano

Published
2025
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44. The impact of radical prostatectomy on global climate: a prospective multicentre study comparing laparoscopic versus robotic surgery

Author

Fuschi, Andrea, Pastore, Antonio Luigi, Al Salhi, Yazan, Martoccia, Alessia, De Nunzio, Cosimo, Tema, Giorgia, Rera, Onofrio Antonio, Carbone, Flavia, Asimakopoulos, Anastasios D., Sequi, Manfredi Bruno, Valenzi, Fabio Maria, Suraci, Paolo Pietro, Scalzo, Silvio, Del Giudice, Francesco, Nardecchia, Stefano, Bozzini, Giorgio, Corsini, Alessandro, Sciarra, Alessandro, and Carbone, Antonio

Published
2024
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47. Design Considerations for 3RRR Parallel Robots with Lightweight, Approximate Static-Balancing

Author

Del Giudice, Giuseppe, Johnston, Garrison L. H., and Simaan, Nabil

Subjects
Computer Science - Robotics
Abstract

Balancing parallel robots throughout their workspace while avoiding the use of balancing masses and respecting design practicality constraints is difficult. Medical robots demand such compact and lightweight designs. This paper considers the difficult task of achieving optimal approximate balancing of a parallel robot throughout a desired task-based dexterous workspace using balancing springs only. While it is possible to achieve perfect balancing in a path, only approximate balancing may be achieved without the addition of balancing masses. Design considerations for optimal robot base placement and the effects of placement of torsional balancing springs are presented. Using a modal representation for the balancing torque requirements, we use recent results on the design of wire-wrapped cam mechanisms to achieve balancing throughout a task-based workspace. A simulation study shows that robot base placement can have a detrimental effect on the attainability of a practical design solution for static balancing. We also show that optimal balancing using torsional springs is best achieved when all springs are at the actuated joints and that the wire-wrapped cam design can significantly improve the performance of static balancing. The methodology presented in this paper provides practical design solutions that yield simple, lightweight and compact designs suitable for medical applications where such traits are paramount.

Published
2023

48. Differences in the estimation solutions between lands legitimized already subjected to local government uses and emphyteusis

Author

Benedetto Manganelli and Francesco Paolo Del Giudice

Subjects
local governement uses, land lease, rent, capital of enfranchisement, estimates, Real estate business, HD1361-1395.5
Abstract

The article addresses real estate appraisals in Italy involving lands already subject to Local Government uses then legitimized or soils burdened by Emphyteusis (Land Lease). Local Government uses are collective property rights on rural land. Considering these conditions, it is possible for the land to be legitimized by the occupant, who thus obtains the right to alienate the land with the burden of the rent. Emphyteusis (Land Lease), on the other hand, is a right of enjoyment on another’s land with the obligation to improve it and pay a periodic rent. These two types of agrarian relationships may appear similar but confusing them can lead to inequalities when updating the rent or quantifying the capital of enfranchisement. Therefore, a historical-legal investigation becomes essential to reconstruct the existence of the right and its particular genesis, in order to identify the true owner of the land between the grantor and the grantee. The work also provides operational suggestions, in the two cases examined, for estimating the rent and capital of enfranchisement that are in line with the prescriptions imposed by case law and represent a fair balance between the various interests of the parties involved.

Published
2024
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49. Anorexia nervosa in children and adolescents: an early detection of risk factors

Author

Elena Bozzola, Sarah Barni, Maria Rosaria Marchili, Romie Hellmann, Emanuela Del Giudice, Giampaolo De Luca, Vita Cupertino, and for the Italian Pediatric Society Adolescent Study Group

Subjects
Pediatrics, RJ1-570
Abstract

Abstract The incidence of eating disorders in children, mainly of anorexia nervosa, is dramatically increased in the last years. A timely identification of the disease is associated with higher rates of recovery. Aim of the work is to underline signs and symptoms that can be used to an early detection of anorexia nervosa in the pediatric age. A scoping review has been conducted by The Italian Pediatric Society Adolescent Study Group according to the PRISMA Extension guidelines for Scoping Reviews, using the search term “anorexia nervosa” and the following filters “review”, “systematic review”, “age 0–18”, “last 4 years”. The strategy search produced 657 studies, of which 52 were included in this revision. Screening and red flags were discussed in 23 reports, genetics in 12, neurological pathways in 11, environmental factors in 10, and gut microbiota in 7. An accurate physiological and pathological anamnesis, physical and psychological examination, including the body perception, should be taken in account as well as the presence of co-morbidities, including chronic functional abdominal pain and autoimmune/autoinflammatory diseases. Evidence suggests the role of familiar predisposition as well as of neurological morphology and pathway in anorexia nervosa development. Gut microbiota has also been included among possible risk factor for developing anorexia nervosa due to a complex direct and indirect interactions between gut and brain. The Italian Pediatric Society Adolescent Study Group suggests performing an accurate familial and personal anamnesis, including psychological evaluation as well as a physical exam including auxological parameters as a screening tool during pediatric checks to better explore the risk of developing anorexia nervosa.

Published
2024
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50. Traffic Signal Setting at Urban Junctions and Fundamental Diagram: A Before-After Study

Author

Alonso, Borja, Del Giudice, Salvatore, Musolino, Giuseppe, and Vitetta, Antonino

Subjects
Government regulation
Abstract

The paper analyses the effects of modifying traffic light regulations at urban road junctions, focussing on the ratio between green time and cycle time, as a function of vehicular traffic variables (flows, density and speed) on the links. The analyses are conducted in an urban setting using a before-and-after approach, employing traffic data detected by loop detectors and traffic light control parameters (the ratio between green time and cycle time) that were actually implemented. The data pertain to a central street in the city of Santander (Spain), collected during several significant weeks in different periods corresponding to varying demands for mobility. In the context of existing studies on the flow-density diagram, a function is estimated that considers the ratio between green time and cycle time as the independent variable and link capacity as the dependent variable. The analysis at the link level may be extended in the future to the network level by incorporating the network fundamental diagram into the traffic signal setting design problem., Author(s): Borja Alonso [1]; Salvatore Del Giudice [2]; Giuseppe Musolino (corresponding author) [3]; Antonino Vitetta [3] 1. Introduction There is a well-established body of scientific literature that defines the unimodal [...]

Published
2025
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