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3. Specific Immunotherapy in Children: The Evidence

Author

La Rosa, M, primary, Lionetti, E, additional, Leonardi, S, additional, Salpietro, A, additional, Bianchi, L, additional, Salpietro, C, additional, Del Giudice, Miraglia M, additional, Ciprandi, G, additional, and Marseglia, Gl, additional

Published
2011
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9. FEF25–75Might Be a Predictive Factor for Bronchial Inflammation and Bronchial Hyperreactivity in Adolescents with Allergic Rhinitis

Author

Ciprandi, G, Tosca, Ma, Castellazzi, Am, Cairello, F, Salpietro, C, Arrigo, T, and Del Giudice, Miraglia M

Abstract

Allergic rhinitis and asthma are closely associated. Bronchial hyperreactivity (BHR) is a pathophysiological characteristic of asthma. Allergic inflammation is characterized by eosinophilic infiltrate and may by indirectly assessed by exhaled nitric oxide (FeNO). Forced expiratory flow between 25% and 75% of vital capacity (FEF25–75) may predict BHR in adult patients with allergic rhinitis. The aim of this study was to evaluate the presence of BHR in a large group of adolescents with allergic rhinitis and whether FEF25–75might be related with BHR and FeNO. Methods 150 adolescents with allergic rhinitis were enrolled. Clinical examination, skin prick test, spirometry, methacholine challenge, and FeNO were performed in all patients. Results Severe BHR is quite frequent in allergic adolescents. Impaired FEF25–75values (such as ? 65% of predicted) constitute a relevant predictive factor for severe BHR (OR 4.4). FeNO levels were significantly related with BHR. Conclusion This study provides evidence that impaired FEF25–75values might predict severe BHR and BHR is related with FeNO in adolescents. Therefore, BHR should be suspected in adolescents with low FEF25–75values.

Published
2011
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11. A POLYCENTRIC, RANDOMIZED, DOUBLE BLIND, PARALLEL-GROUP, PLACEBO- CONTROLLED STUDY ON LERTAL (R), A MULTICOMPONENT NUTRACEUTICAL, AS ADD-ON TREATMENT IN CHILDREN WITH ALLERGIC RHINOCONJUNCTIVITIS: PHASE I DURING ACTIVE TREATMENT

Author

Zicari, A., Verrotti, A., Tosca, M. A., Salpietro, C., Pogliani, L., Podesta, A., Pellegrini, G., Paravati, F., Del Giudice, Miraglia M., Minasi, D., Martelli, A., Marchisio, P., Leonardi, S., Giordano, P., Cherubini, S., Cardinale, F., Ilaria Brambilla, Ciprandi, G., Licari, A., and Marseglia, G. L.

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