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3. Nuclear physics midterm plan at Legnaro National Laboratories (LNL)

Author

Ballan, M., Bottoni, S., Caamaño, M., Caciolli, A., Campostrini, M., Cicerchia, M., Crespi, F. C. L., Cristallo, S., Dell’Aquila, D., Depalo, R., Fioretto, E., Galtarossa, F., Gasques, L. R., Gottardo, A., Gramegna, F., Gulminelli, F., Kurtukian-Nieto, T., La Cognata, M., Lenzi, S. M., Marchi, T., Mazurek, K., Mengoni, D., Mou, L., Nania, R., Pupillo, G., Valiente-Dobón, J. J., Zanon, I., Acosta, L., Alvarez, M. A. G., Andrighetto, A., Arazi, A., Arzenton, A., Assié, M., Bagatin, M., Barbaro, F., Barbieri, C., Barlini, S., Basiricò, L., Battistoni, G., Beaumel, D., Bentley, M. A., Benzoni, G., Bertoldo, S., Bertulani, C., Bonasera, A., Camaiani, A., Canton, L., Capirossi, V., Carante, M. P., Carraro, C., Carturan, S. M., Casini, G., Cavanna, F., Centofante, L., Chávez, E. R., Chbihi, A., Ciemała, M., Cisternino, S., Colombi, A., Colucci, M., Compagnucci, A., Corradetti, S., Corradi, L., D’Agata, G., de Angelis, G., De Dominicis, L., De Salvador, D., DeFilippo, E., Del Fabbro, M., Di Nitto, A., Ditalia Tchernij, S., Donzella, A., Duguet, T., Esposito, J., Favela, F., Fernández-García, J. P., Flavigny, F., Fontana, A., Fornal, B., Forneris, J., Fraboni, B., Frankland, J., Gamba, E., Geraci, E., Gerardin, S., Giuliani, S. A., Gnoffo, B., Groppi, F., Gruyer, D., Haddad, F., Isaak, J., Kmiecik, M., Koning, A., Lamia, L., Le Neindre, N., Leoni, S., Lépine-Szily, A., Lilli, G., Lombardo, I., Loriggiola, M., Loriggiola, L., Lunardon, M., Maggioni, G., Maj, A., Manenti, S., Manzolaro, M., Marcucci, L. E., Marín-Lámbarri, D. J., Mariotti, E., Martin Hernandez, G., Massimi, C., Mastinu, P., Mazzocco, M., Mazzolari, A., Mijatović, T., Mishenina, T., Mizuyama, K., Monetti, A., Montagnoli, G., Morselli, L., Moschini, L., Musacchio Gonzalez, E., Nannini, A., Niu, Y. F., Ota, S., Paccagnella, A., Palmerini, S., Pellegri, L., Perego, A., Piantelli, S., Piatti, D., Picollo, F., Pignatari, M., Pinna, F., Pirrone, S., Pizzone, R. G., Polettini, M., Politi, G., Popescu, L., Prete, G., Quaranta, A., Raabe, R., Ramos, J. P., Raniero, W., Rapisarda, G. G., Recchia, F., Rigato, V., Roca Maza, X., Rocchini, M., Rodriguez, T., Roncolato, C., Rudolph, D., Russotto, P., Sánchez-Benítez, Á. M., Savran, D., Scarpa, D., Scheck, M., Sekizawa, K., Sergi, M. L., Sgarbossa, F., Silvestrin, L., Singh Khwairakpam, O., Skowronski, J., Somà, V., Spartà, R., Spieker, M., Stefanini, A. M., Steiger, H., Stevanato, L., Stock, M. R., Vardaci, E., Verney, D., Vescovi, D., Vittone, E., Werner, V., Wheldon, C., Wieland, O., Wimmer, K., Wyss, J., Zago, L., and Zenoni, A.

Published
2023
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4. Conceptual design of the AGATA 2[formula omitted] array at LNL

Author

Valiente-Dobón, J.J., Menegazzo, R., Goasduff, A., Agguiaro, D., Aguilera, P., Angelini, F., Balogh, M., Bazzacco, D., Benito, J., Benzoni, G., Bez, N., Bolognesi, M., Bottoni, S., Brugnara, D., Carollo, S., Cocconi, P., Cogo, A., Collado, J., Crespi, F.C.L., Ertoprak, A., Escudeiro, R., Galtarossa, F., Gamba, E.R., Gambalonga, A., Servín, B. Góngora, Gottardo, A., Gozzelino, A., Gulmini, M., Huang, Z., Marchi, T., Mengoni, D., Modanese, P., Napoli, D.R., Pellumaj, J., Pérez-Vidal, R.M., Pigliapoco, S., Pilotto, E., Ramina, L., Rampazzo, M., Raniero, W., Rebeschini, M., Rezynkina, K., Rosso, D., Scarcioffolo, M., Scarpa, D., Sedlák, M., Smith, R., Toniolo, N., Veronese, F., Volpe, V., Zago, L., Zanon, I., Zhang, G., Abels, R., Allegrini, M.L., Aufranc, C., Baulieu, G., Belkhiria, C., Benettoni, M., Benini, D., Bentley, M., Biasotto, M., Blaizot, M., Miquel, J. Blasco, Boiano, C., Boston, A., Boston, H., Boujrad, A., Bourgault, P., Bracco, A., Brambilla, S., Burrows, I., Camera, F., Capra, S., Capsoni, A., Cash, R., Civera, J.V., Clément, E., Coelli, S., Cordwell, M., Corradi, L., Coudert, S., De Angelis, G., De Ruvo, L., Debras, G., Del Fabbro, M., Diklić, J., Dosme, N., Duchene, G., Duclos, B., Dudouet, J., Eberth, J., Elloumi, S., Everett, C., Fantinel, S., Fillinger, M., Fioretto, E., Fransen, C., Gadea, A., Gibelin, L., González, V., Goupil, J., Görgen, C., Grant, A., Green, K., Ha, J., Hartnett, T., Henseler, K., Hess, H., Hirsch, R., Houarner, C., Jacob, J., Joannem, T., Judson, D.S., Karkour, N., Karolak, M., Kebbiri, M., Kieffer, J., Labiche, M., Lafay, X., Le Jeannic, P., Lefevre, A., Legay, E., Legruel, F., Lenzi, S., Leoni, S., Linget, D., Liptrot, M., López-Martens, A., Lotodé, A., Manara, L., Ménager, L., Mijatović, T., Million, B., Minarello, A., Montagnoli, G., Morrall, P., Mullacrane, I., Nyberg, J., Philippon, G., Polettini, M., Popieul, F., Pullia, A., Recchia, F., Reiter, P., Richardt, G., Rocchini, M., Roger, A., Saillant, F., Sanchis, E., Laskar, Md.S.R., Secci, G., Sigward, M.-H., Simpson, J., Solenne, N., Spee, F., Stefanini, A.M., Stézowski, O., Szilner, S., Templeton, N., Theisen, Ch., Thiel, S., Tomasi, F., Tzvetkov, S., Vigano, D., Viscione, E., Wieland, O., Wimmer, K., Wittwer, G., and Zielińska, M.

Published
2023
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7. Digital Planning and Manufacturing of Maxillary Skeletal Expander for Patients with Thin Palatal Bone

Author

Cantarella D, Karanxha L, Zanata P, Moschik C, Torres A, Savio G, Del Fabbro M, and Moon W

Subjects
digital orthodontics, mse, maxillary transverse deficiency, palatal expansion, marpe, Medical technology, R855-855.5
Abstract

Daniele Cantarella,1 Lorena Karanxha,1 Paolo Zanata,2 Christoph Moschik,3 Ana Torres,3 Gianpaolo Savio,4 Massimo Del Fabbro,1,5 Won Moon6,7 1Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy; 2Private Dental Laboratory Practice, Castelfranco Veneto, Italy; 3Private Orthodontic Practice, Munich, Germany; 4Department of Civil, Environmental and Architectural Engineering ICEA, University of Padova, Padova, Italy; 5IRCCS Orthopedic Institute Galeazzi, Milan, Italy; 6Orthodontics, The Forsyth Institute, Cambridge, MA, USA; 7Department of Orthodontics, Institute of Oral Health Science, Ajou University School of Medicine, Suwon, KoreaCorrespondence: Daniele CantarellaDepartment of Biomedical, Surgical and Dental Sciences, University of Milan, via Commenda 10, Milan, ItalyEmail danielecant@hotmail.comAbstract: The miniscrew-assisted rapid palatal expansion approach has given new opportunities for the treatment of maxilla transverse deficiency by providing an alternative to the surgical approach for adult patients. However, the presence of a thin palatal bone can compromise the success of such approach. Recently, the digital planning of the miniscrew-assisted appliances has offered unique advantages in terms of safety and accuracy of the overall process. The aim of this study is to describe the digital planning and MSE fabrication with cad-cam technology using 6 mini-screws in cases with a palatal bone thickness of less than 2.5 mm.Keywords: digital orthodontics, MSE, maxillary transverse deficiency, palatal expansion, MARPE

Published
2021

8. A New Methodology for the Digital Planning of Micro-Implant-Supported Maxillary Skeletal Expansion

Author

Cantarella D, Savio G, Grigolato L, Zanata P, Berveglieri C, Lo Giudice A, Isola G, Del Fabbro M, and Moon W

Subjects
miniscrew-assisted rapid palatal expansion (marpe), cone beam computed tomography (cbct), mse, digital planning and workflow, virtual planning, temporary anchorage device (tad), cephalometrics-based digital planning (cbdp), Medical technology, R855-855.5
Abstract

Daniele Cantarella,1 Gianpaolo Savio,2 Luca Grigolato,2 Paolo Zanata,3 Chiara Berveglieri,4 Antonino Lo Giudice,5,6 Gaetano Isola,5 Massimo Del Fabbro,1 Won Moon7 1Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy; 2Department of Civil, Environmental and Architectural Engineering ICEA, University of Padova, Padova, Italy; 3Private Practice, Castelfranco Veneto, Italy; 4Private Practice of Orthodontics, Bondeno, Italy; 5Department of General Surgery and Surgical-Medical Specialties, Section of Orthodontics, School of Dentistry, University of Catania, Catania, Italy; 6Department of Biomedical and Dental Sciences and Morphofunctional Imaging, Section of Orthodontics, University of Messina, Messina, Italy; 7Division of Growth and Development, Section of Orthodontics, School of Dentistry, Center for Health Science, University of California, Los Angeles, Los Angeles, CA, USACorrespondence: Daniele CantarellaDepartment of Biomedical, Surgical and Dental Sciences, University of Milan, Via Commenda 10, Milan, ItalyEmail danielecant@hotmail.comIntroduction: Miniscrew-assisted rapid palatal expansion (MARPE) appliances utilize the skeletal anchorage to expand the maxilla. One type of MARPE device is the Maxillary Skeletal Expander (MSE), which presents four micro-implants with bicortical engagement of the palatal vault and nasal floor. MSE positioning is traditionally planned using dental stone models and 2D headfilms. This approach presents some critical issues, such as the inability to identify the MSE position relative to skeletal structures, and the potential risk of damaging anatomical structures.Methods: A novel methodology has been developed to plan MSE position using the digital model of dental arches and cone-beam computed tomography (CBCT). A virtual model of MSE appliance with the four micro-implants was created. After virtual planning, a positioning guide is virtually designed, 3D printed, and utilized to model and weld the MSE supporting arms to the molar bands. The expansion device is then cemented in the patient oral cavity and micro-implants inserted. A clinical case of a 12.9-year-old female patient presenting a Class III malocclusion with transverse and sagittal maxillary deficiency is reported.Results: The midpalatal suture was opened with a split of 3.06 mm and 2.8 mm at the anterior and posterior nasal spine, respectively. After facemask therapy, the sagittal skeletal relationship was improved, as shown by the increase in ANB, A-Na perpendicular and Wits cephalometric parameters, and the mandibular plane rotated 1.6° clockwise.Conclusion: The proposed digital methodology represents an advancement in the planning of MSE positioning, compared to the traditional approach. By evaluating the bone morphology of the palate and midface on patient CBCT, the placement of MSE is improved regarding the biomechanics of maxillary expansion and the bone thickness at micro-implants insertion sites. In the present case report, the digital planning was associated with a positive outcome of maxillary expansion and protraction in safety conditions.Keywords: miniscrew-assisted rapid palatal expansion, MARPE, CBCT, MSE, virtual planning, cephalometrics-based digital planning, CBDP, workflow, TAD

Published
2020

10. Quality of life in oncologic patients after maxillectomy operations: clinical case series on different rehabilitation protocols.

Author

GOKER, F., BONASO, M., GRECCHI, E., GRIVETTO, F., STEFANELLI, L. V., BRUCOLI, M., DONATI, G., KISNISCI, R., DEL FABBRO, M., and GRECCHI, F.

Abstract

OBJECTIVE: The study's purpose was to compare the quality of life (QoL) in oncologic patients treated with different rehabilitation protocols following maxillary tumor resections. PATIENTS AND METHODS: The patients were divided into three groups. Group A: 18 patients with maxillary obturator prosthesis. Group B: 17 patients with simultaneous autologous tissue reconstruction. Group C: 12 patients with prosthesis on zygomatic implants. The post-operative QoL was compared using standard questionnaires, investigating items like pain, mood, social relations, and specific functions that could potentially compromise the post-operative QoL. A secondary analysis compared reconstructed vs. non-reconstructed pa-tients. RESULTS: Most questionnaire items did not show significant differences among groups. Statistically significant outcomes were found in two parameters (social contact and sexuality), in which patients treated with zygomatic implants had the best satisfaction, and patients with obturator prostheses showed the lowest satisfaction. Patients belonging to the non-reconstructed group showed better moods than those in the reconstructed group, while taste problem complaints and pain were lower in the reconstructed group. CONCLUSIONS: Although the type of reconstruction procedure depends on the type of maxillectomy to be performed and on the general health situation of each patient, the impact of the rehabilitation protocol on the patients' QoL should be accounted for when planning the treatment. [ABSTRACT FROM AUTHOR]

Published
2024

11. Multicenter study of patients’ preferences and concerns regarding the origin of bone grafts utilized in dentistry

Author

Bucchi C, del Fabbro M, Arias A, Fuentes R, Mendes JM, Ordonneau M, Orti V, and Manzanares-Céspedes MC

Subjects
survey, patient’s concerns, bone graft materials, animal products, tissue donation., Medicine (General), R5-920
Abstract

Cristina Bucchi,1,2 Massimo del Fabbro,3,4 Alain Arias,2 Ramón Fuentes,2 José Manuel Mendes,5 Marie Ordonneau,6 Valérie Orti,7 María-Cristina Manzanares-Céspedes6 1PhD Program in Medicine and Translational Research, Universitat de Barcelona, Barcelona, Spain; 2Department of Integral Adults Dentistry, Research Centre for Dental Sciences (CICO), Dental School, Universidad de La Frontera, Temuco, Chile; 3Department of Biomedical, Surgical and Dental Sciences, Università degli Studi di Milano, Milan, Italy; 4IRCCS Orthopedic Institute Galeazzi, Milan, Italy; 5CESPU, IINFACTS, Institute of Research and Advanced Training in Health Sciences and Technologies, Department of Dental Sciences, Portugal; 6Faculty of Medicine and Health Sciences, Universitat de Barcelona, Barcelona, Spain; 7Department of Periodontology, Dental School, University of Montpellier, Montpellier, France Purpose: Bone graft materials can be obtained from the patient’s own body (autologous graft), animals (xenograft), human cadavers (allograft) and synthetic materials (alloplastic bone graft). Patients may have ethical, religious or medical concerns about the origin of bone grafts, which could lead them to reject the use of certain types of bone graft in their treatments. The aim of this multicenter study, which surveyed patients from five university clinics in Portugal, France, Italy, Spain and Chile, was to analyze patients’ opinions regarding the source of bone grafts. Patients and methods: A survey composed of ten questions was translated into local languages and validated. Patients were asked about the degree of acceptance/rejection of each graft and the reasons for rejection. A chi-squared test was used to analyze statistically significant differences. Results: Three hundred thirty patients were surveyed. The grafts that elicited the highest percentage of refusal were allograft (40.4%), autologous bone graft from an extraoral donor site (34%) and xenograft (32.7%). The grafts with the lowest rate of refusal were alloplastic (6.3%) and autologous bone grafts from an intraoral donor site (24.5%). The main reason for autologous bone rejection was the fear of pain and discomfort, for xenograft it was the fear of disease transmission and the rejection of use of animals for human benefit, and for allograft it was ethical/moral motivations and the fear of disease transmission. Religious affiliation influenced patient’s preferences. Conclusion: The origin of bone grafts is still conflictive for a high percentage of patients. Keywords: survey, patient’s concerns, bone graft materials, animal products, tissue donation

Published
2019

14. Salivary proteomic profile of young healthy subjects.

Author

Dongiovanni, P., Meroni, M., Aiello, Gilda, D'Amato, A., Cenzato, N., Casati, S., Damiani, G., Fenoglio, C., Galimberti, D., Grossi, E., Prati, D., Lamorte, G., Bianco, C., Valenti, L., Soggiu, A., Zapperi, S., La Porta, C. A. M., Del Fabbro, M., and Tartaglia, G. M.

Published
2023
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15. Chilblain-like lesions (COVID-19 toes) have the same impact on family members than psoriasis systemically treated: insights from a case-control study targeting the pediatric population

Author

Damiani, G, Finelli, R, Kridin, K, Pacifico, A, Bragazzi, N L, Malagoli, P, Fabbrocini, G, Bonifazi, E, Mazzotta, F, Lovati, C, Savoia, P, Gironi, L C, Morello, M, Davidson, T, Watad, A, Goker, F, Mortellaro, C, Del Fabbro, M, Damiani, G, Finelli, R, Kridin, K, Pacifico, A, Bragazzi, N L, Malagoli, P, Fabbrocini, G, Bonifazi, E, Mazzotta, F, Lovati, C, Savoia, P, Gironi, L C, Morello, M, Davidson, T, Watad, A, Goker, F, Mortellaro, C, and Del Fabbro, M

Subjects
COVID-19 toes, Chilblain-like lesions, Settore MED/17 - Malattie Infettive, Dermatitis family impact, Psoriasis, Pediatrics, Settore MED/29 - Chirurgia Maxillofacciale
Abstract

Objective: COVID-19 toes represent the main dermatological COVID-19 cutaneous manifestation in pediatric patients. Its diagnosis exposes the whole family to social stigma and this aspect was not previously evaluated. Patients and methods: This was a multicenter, case-control, observational study that compared the family impact of COVID-19 toes vs. psoriasis (PsO). We enrolled 46 pediatric patients (23 with psoriasis and 23 with COVID-19 toes, age and gender matched) and their parents/caregivers that had to fill the Dermatitis Family Impact (DFI) questionnaire. Results: DFI index did not differ significantly between both subgroups (p=0.48), and in psoriatic patients did not correlate with both Psoriasis Area Severity Index (PASI) (p=0.59) and itch-VAS (p=0.16). Conclusions: COVID-19 toes, a transitory dermatosis, exerted a similar impact/perturbation on family dynamics than PsO, a well-known stigmatizing, chronic inflammatory dermatosis.

Published
2023

16. Conceptual design of the AGATA 2π array at LNL

Author

Valiente-Dobón, J.J., primary, Menegazzo, R., additional, Goasduff, A., additional, Agguiaro, D., additional, Aguilera, P., additional, Angelini, F., additional, Balogh, M., additional, Bazzacco, D., additional, Benito, J., additional, Benzoni, G., additional, Bez, N., additional, Bolognesi, M., additional, Bottoni, S., additional, Brugnara, D., additional, Carollo, S., additional, Cocconi, P., additional, Cogo, A., additional, Collado, J., additional, Crespi, F.C.L., additional, Ertoprak, A., additional, Escudeiro, R., additional, Galtarossa, F., additional, Gamba, E.R., additional, Gambalonga, A., additional, Servín, B. Góngora, additional, Gottardo, A., additional, Gozzelino, A., additional, Gulmini, M., additional, Huang, Z., additional, Marchi, T., additional, Mengoni, D., additional, Modanese, P., additional, Napoli, D.R., additional, Pellumaj, J., additional, Pérez-Vidal, R.M., additional, Pigliapoco, S., additional, Pilotto, E., additional, Ramina, L., additional, Rampazzo, M., additional, Raniero, W., additional, Rebeschini, M., additional, Rezynkina, K., additional, Rosso, D., additional, Scarcioffolo, M., additional, Scarpa, D., additional, Sedlák, M., additional, Smith, R., additional, Toniolo, N., additional, Veronese, F., additional, Volpe, V., additional, Zago, L., additional, Zanon, I., additional, Zhang, G., additional, Abels, R., additional, Allegrini, M.L., additional, Aufranc, C., additional, Baulieu, G., additional, Belkhiria, C., additional, Benettoni, M., additional, Benini, D., additional, Bentley, M., additional, Biasotto, M., additional, Blaizot, M., additional, Miquel, J. Blasco, additional, Boiano, C., additional, Boston, A., additional, Boston, H., additional, Boujrad, A., additional, Bourgault, P., additional, Bracco, A., additional, Brambilla, S., additional, Burrows, I., additional, Camera, F., additional, Capra, S., additional, Capsoni, A., additional, Cash, R., additional, Civera, J.V., additional, Clément, E., additional, Coelli, S., additional, Cordwell, M., additional, Corradi, L., additional, Coudert, S., additional, De Angelis, G., additional, De Ruvo, L., additional, Debras, G., additional, Del Fabbro, M., additional, Diklić, J., additional, Dosme, N., additional, Duchene, G., additional, Duclos, B., additional, Dudouet, J., additional, Eberth, J., additional, Elloumi, S., additional, Everett, C., additional, Fantinel, S., additional, Fillinger, M., additional, Fioretto, E., additional, Fransen, C., additional, Gadea, A., additional, Gibelin, L., additional, González, V., additional, Goupil, J., additional, Görgen, C., additional, Grant, A., additional, Green, K., additional, Ha, J., additional, Hartnett, T., additional, Henseler, K., additional, Hess, H., additional, Hirsch, R., additional, Houarner, C., additional, Jacob, J., additional, Joannem, T., additional, Judson, D.S., additional, Karkour, N., additional, Karolak, M., additional, Kebbiri, M., additional, Kieffer, J., additional, Labiche, M., additional, Lafay, X., additional, Le Jeannic, P., additional, Lefevre, A., additional, Legay, E., additional, Legruel, F., additional, Lenzi, S., additional, Leoni, S., additional, Linget, D., additional, Liptrot, M., additional, López-Martens, A., additional, Lotodé, A., additional, Manara, L., additional, Ménager, L., additional, Mijatović, T., additional, Million, B., additional, Minarello, A., additional, Montagnoli, G., additional, Morrall, P., additional, Mullacrane, I., additional, Nyberg, J., additional, Philippon, G., additional, Polettini, M., additional, Popieul, F., additional, Pullia, A., additional, Recchia, F., additional, Reiter, P., additional, Richardt, G., additional, Rocchini, M., additional, Roger, A., additional, Saillant, F., additional, Sanchis, E., additional, Laskar, Md.S.R., additional, Secci, G., additional, Sigward, M.-H., additional, Simpson, J., additional, Solenne, N., additional, Spee, F., additional, Stefanini, A.M., additional, Stézowski, O., additional, Szilner, S., additional, Templeton, N., additional, Theisen, Ch., additional, Thiel, S., additional, Tomasi, F., additional, Tzvetkov, S., additional, Vigano, D., additional, Viscione, E., additional, Wieland, O., additional, Wimmer, K., additional, Wittwer, G., additional, and Zielińska, M., additional

Published
2023
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17. Conceptual design of the AGATA 2 pi array at LNL

Author

Valiente-Dobon, J. J., Menegazzo, R., Goasduff, A., Agguiaro, D., Aguilera, P., Angelini, F., Balogh, M., Bazzacco, D., Benito, J., Benzoni, G., Bez, N., Bolognesi, M., Bottoni, S., Brugnara, D., Carollo, S., Cocconi, P., Cogo, A., Collado, J., Crespi, F. C. L., Ertoprak, A., Escudeiro, R., Galtarossa, F., Gamba, E. R., Gambalonga, A., Gongora Servin, B., Gottardo, A., Gozzelino, A., Gulmini, M., Huang, Z., Marchi, T., Mengoni, D., Modanese, P., Napoli, D. R., Pellumaj, J., Perez-Vidal, R. M., Pigliapoco, S., Pilotto, E., Ramina, L., Rampazzo, M., Raniero, W., Rebeschini, M., Rezynkina, K., Rosso, D., Scarcioffolo, M., Scarpa, D., Sedlak, M., Smith, R., Toniolo, N., Veronese, F., Volpe, V., Zago, L., Zanon, I., Zhang, G., Abels, R., Allegrini, M. L., Aufranc, C., Baulieu, G., Belkhiria, C., Benettoni, M., Benini, D., Bentley, M., Biasotto, M., Blaizot, M., Miquel, J. Blasco, Boiano, C., Boston, A., Boston, H., Boujrad, A., Bourgault, P., Bracco, A., Brambilla, S., Burrows, I., Camera, F., Capra, S., Capsoni, A., Cash, R., Civera, J. V., Clement, E., Coelli, S., Cordwell, M., Corradi, L., Coudert, S., De Angelis, G., De Ruvo, L., Debras, G., Del Fabbro, M., Diklic, J., Dosme, N., Duchene, G., Duclos, B., Dudouet, J., Eberth, J., Elloumi, S., Everett, C., Fantinel, S., Fillinger, M., Fioretto, E., Fransen, C., Gadea, A., Gibelin, L., Gonzalez, V., Goupil, J., Goergen, C., Grant, A., Green, K., Ha, J., Hartnett, T., Henseler, K., Hess, H., Hirsch, R., Houarner, C., Jacob, J., Joannem, T., Judson, D. S., Karkour, N., Karolak, M., Kebbiri, M., Kieffer, J., Labiche, M., Lafay, X., Le Jeannic, P., Lefevre, A., Legay, E., Legruel, F., Lenzi, S., Leoni, S., Linget, D., Liptrot, M., Lopez-Martens, A., Lotode, A., Manara, L., Menager, L., Mijatovic, T., Million, B., Minarello, A., Montagnoli, G., Morrall, P., Mullacrane, I., Nyberg, Johan, Philippon, G., Polettini, M., Popieul, F., Pullia, A., Recchia, F., Reiter, P., Richardt, G., Rocchini, M., Roger, A., Saillant, F., Sanchis, E., Laskar, Md. S. R., Secci, G., Sigward, M. H., Simpson, J., Solenne, N., Spee, F., Stefanini, A. M., Stezowski, O., Szilner, S., Templeton, N., Theisen, Ch., Thiel, S., Tomasi, F., Tzvetkov, S., Vigano, D., Viscione, E., Wieland, O., Wimmer, K., Wittwer, G., Zielinska, M., Valiente-Dobon, J. J., Menegazzo, R., Goasduff, A., Agguiaro, D., Aguilera, P., Angelini, F., Balogh, M., Bazzacco, D., Benito, J., Benzoni, G., Bez, N., Bolognesi, M., Bottoni, S., Brugnara, D., Carollo, S., Cocconi, P., Cogo, A., Collado, J., Crespi, F. C. L., Ertoprak, A., Escudeiro, R., Galtarossa, F., Gamba, E. R., Gambalonga, A., Gongora Servin, B., Gottardo, A., Gozzelino, A., Gulmini, M., Huang, Z., Marchi, T., Mengoni, D., Modanese, P., Napoli, D. R., Pellumaj, J., Perez-Vidal, R. M., Pigliapoco, S., Pilotto, E., Ramina, L., Rampazzo, M., Raniero, W., Rebeschini, M., Rezynkina, K., Rosso, D., Scarcioffolo, M., Scarpa, D., Sedlak, M., Smith, R., Toniolo, N., Veronese, F., Volpe, V., Zago, L., Zanon, I., Zhang, G., Abels, R., Allegrini, M. L., Aufranc, C., Baulieu, G., Belkhiria, C., Benettoni, M., Benini, D., Bentley, M., Biasotto, M., Blaizot, M., Miquel, J. Blasco, Boiano, C., Boston, A., Boston, H., Boujrad, A., Bourgault, P., Bracco, A., Brambilla, S., Burrows, I., Camera, F., Capra, S., Capsoni, A., Cash, R., Civera, J. V., Clement, E., Coelli, S., Cordwell, M., Corradi, L., Coudert, S., De Angelis, G., De Ruvo, L., Debras, G., Del Fabbro, M., Diklic, J., Dosme, N., Duchene, G., Duclos, B., Dudouet, J., Eberth, J., Elloumi, S., Everett, C., Fantinel, S., Fillinger, M., Fioretto, E., Fransen, C., Gadea, A., Gibelin, L., Gonzalez, V., Goupil, J., Goergen, C., Grant, A., Green, K., Ha, J., Hartnett, T., Henseler, K., Hess, H., Hirsch, R., Houarner, C., Jacob, J., Joannem, T., Judson, D. S., Karkour, N., Karolak, M., Kebbiri, M., Kieffer, J., Labiche, M., Lafay, X., Le Jeannic, P., Lefevre, A., Legay, E., Legruel, F., Lenzi, S., Leoni, S., Linget, D., Liptrot, M., Lopez-Martens, A., Lotode, A., Manara, L., Menager, L., Mijatovic, T., Million, B., Minarello, A., Montagnoli, G., Morrall, P., Mullacrane, I., Nyberg, Johan, Philippon, G., Polettini, M., Popieul, F., Pullia, A., Recchia, F., Reiter, P., Richardt, G., Rocchini, M., Roger, A., Saillant, F., Sanchis, E., Laskar, Md. S. R., Secci, G., Sigward, M. H., Simpson, J., Solenne, N., Spee, F., Stefanini, A. M., Stezowski, O., Szilner, S., Templeton, N., Theisen, Ch., Thiel, S., Tomasi, F., Tzvetkov, S., Vigano, D., Viscione, E., Wieland, O., Wimmer, K., Wittwer, G., and Zielinska, M.

Abstract

The Advanced GAmma Tracking Array (AGATA) has been installed at Laboratori Nazionali di Legnaro (LNL), Italy. In this installation, AGATA will consist, at the beginning, of 13 AGATA triple clusters (ATCs) with an angular coverage of 1n,and progressively the number of ATCs will increase up to a 2 pi angular coverage. This setup will exploit both stable and radioactive ion beams delivered by the Tandem-PIAVE-ALPI accelerator complex and the SPES facility. The new implementation of AGATA at LNL will be used in two different configurations, firstly one coupled to the PRISMA large-acceptance magnetic spectrometer and lately a second one at Zero Degrees, along the beam line. These two configurations will allow us to cover a broad physics program, using different reaction mechanisms, such as Coulomb excitation, fusion-evaporation, transfer and fission at energies close to the Coulomb barrier. These setups have been designed to be coupled with a large variety of complementary detectors such as charged particle detectors, neutron detectors, heavy-ion detectors, high-energy gamma-ray arrays, cryogenic and gasjet targets and the plunger device for lifetime measurements. We present in this paper the conceptual design, characteristics and performance figures of this implementation of AGATA at LNL.

Published
2023
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18. The Maxilla-Mandibular Discrepancies through Soft-Tissue References: Reliability and Validation of the Anteroposterior Measurement

Author

Maspero, C, Cenzato, N, Inchingolo, F, Cagetti, M, Isola, G, Sozzi, D, Del Fabbro, M, Tartaglia, G, Maspero, Cinzia, Cenzato, Niccolò, Inchingolo, Francesco, Cagetti, Maria Grazia, Isola, Gaetano, Sozzi, Davide, Del Fabbro, Massimo, Tartaglia, Gianluca Martino, Maspero, C, Cenzato, N, Inchingolo, F, Cagetti, M, Isola, G, Sozzi, D, Del Fabbro, M, Tartaglia, G, Maspero, Cinzia, Cenzato, Niccolò, Inchingolo, Francesco, Cagetti, Maria Grazia, Isola, Gaetano, Sozzi, Davide, Del Fabbro, Massimo, and Tartaglia, Gianluca Martino

Abstract

This research aimed to identify a new measurement to diagnose the sagittal maxillary and mandibular difference that considers the patient’s profile (soft tissue Wits appraisal: obtained by projecting points A and B on the occlusal plane and subsequently measuring the linear distance between the two points). This new measurement was compared to the conventional Wits appraisal obtained to diagnose sagittal jaw discrepancy. In total, 300 subjects (162 males, 138 females) aged between 6 and 50 years requiring orthodontic treatment were analyzed. The cephalometric tracings on the pre-treatment lateral cephalometric radiographs were obtained and the two measurements taken were the Wits appraisal and a new measurement which were both calculated and compared. The analysis of the linear correlations between the conventional Wits value and the measurement obtained on the soft-tissue were undertaken. The relevance was established at 5% (p < 0.05). The mean values were also calculated within sex and age classes, and comparisons between sexes were obtained employing the t test Student’s for independent samples. Subsequently, chi-square analysis was also utilized to verify the sex distributions in the age groups considered. The results obtained suggested that these two measurements were significantly correlated with each other, with no characteristic patterns of sex or age. These data allowed an estimation of the reference values of the new measurement (−1.9 mm and 5.4 mm for patients with Class I molar relationship) showing that the former was more variable than the latter. The new measurement could allow for an accurate evaluation of the jaws sagittal discrepancy from soft tissue analysis.

Published
2023

19. Oral rehabilitation of oncology patients with dental implants after reconstruction surgery with autogenous flaps

Author

Goker, F., Beretta, P., Baj, A., Bolzoni, A.R., Maiorana, C., Beltramini, G., Russillo, A., Greco Lucchina, A., Rossi, D.S., Polo, M.R.D., Del Fabbro, M., Mortellaro, C., and Giannì, A.B.

Subjects
Autogenous flaps, Dental implants, Oral rehabilitation, Oncologic patients, Maxillofacial reconstructive surgery, Settore MED/29 - Chirurgia Maxillofacciale
Abstract

Reconstruction after radical cancer surgery in terms of function and esthetics can be quite demanding. The aim of this study was to evaluate oral rehabilitation with autogenous flaps and dental implants for maxillofacial reconstruction in oncologic patients after implant insertions.The study consisted of 19 patients diagnosed with either squamous cell carcinoma, fusocellular carcinoma, or mucoepidermoid carcinoma. The reconstruction of the maxillofacial defects was done with autogenous flaps (free fibular flap, antero-lateral thigh flap, radial forearm flap, or rotational pedicled temporal muscle flap). Implants were inserted on the average 32.03±19.51 months after reconstructive operations. A total of 82 implants were inserted. Mean follow-up after maxillo-facial surgery was 7.2 years (mean 86.56±22.04 months). Mean follow-up after implant insertions was 4.5 years (mean 54.6±21.82). Primary outcome was implant survival. Secondary outcome was evaluation of post-surgical complications.There were surgical revisions in seven patients after reconstructive surgery with flaps, mainly due to tumor relapse. Complications were seen in 11 patients. There was one implant failure. Overall implant survival rate was 98.8%. No relations were found between implant survival rate and gender, type of tumor, type of microvascular free flap, radiation therapy, chemotherapy, and prosthesis type.According to the results of this study, oral rehabilitation with dental implants inserted in free flaps for maxillofacial reconstruction after ablative oncologic surgery can be considered as a safe treatment modality with successful outcomes.

Published
2023

20. Solitary fibrous tumor of parotid gland: a case report and short review of literature

Author

Goker, F., Mazzucato, C., Maggioni, M., Baj, A., Giannì, A.B., Beltramini, G., Russillo, A., Buccellato, F.R.P., Rossi, D.S., Mortellaro, C., and Del Fabbro, M.

Subjects
Salivary gland, Aged, 80 and over, Solitary fibrous tumor, Parotid gland, Fine needle aspiration cytology, Differential diagnosis, Solitary Fibrous Tumors, Humans, Parotid Gland, Female, Settore MED/29 - Chirurgia Maxillofacciale, Parotid Neoplasms
Abstract

This case report represents a solitary fibrous tumor, which is a very rare neoplasm in the parotid gland.80-year-old Caucasian female patient with palpable, immobile, painless, slow growing, semi-rigid-elastic neoplasm in the left parotid gland, that was existing for four months. There were no signs of inflammation and facial paralysis. The tumor was initially interpreted as a salivary gland neoplasm of uncertain origin. Fine needle aspiration was performed 2 times; however, the precise diagnosis was challenging. The tumor was excised, regional lymphadenectomy was performed. Morphological and immunophenotypical findings were consistent with solitary fibrous tumor of parotid gland. Currently, the patient is under regular follow-up period at 9 months with no evidence of metastasis or recurrence.Although very rare, solitary fibrous tumor (SFT) should be suspected in cases of slow growing, solid, well-defined nodules of the parotid gland. The SFT of the parotid gland are usually benign tumors, however there is a low risk of recurrency and malignant behavior with metastatic potential. Complete resection of the tumor should be performed since it is crucial for management without any recurrence.

Published
2023

21. Clinical outcomes of fully and partially threaded zygomatic implants in a cohort of patients with minimum 7.5-year follow-up

Author

Goker, F., Grecchi, F., Grecchi, E., Del Fabbro, M., Agliardi, E.L., Buccellato, F.R.P., Greco Lucchina, A., Giannì, A.B., and Mortellaro, C.

Subjects
Extra-sinus zygomatic implants, Maxillary atrophy, Zygomatic implants, Oral rehabilitation, Dental implants, Settore MED/29 - Chirurgia Maxillofacciale
Abstract

The aim of this retrospective case series report was to evaluate the results of oral rehabilitation with extra-sinus zygomatic implant surgery with a minimum follow-up of 7.5 years.A total of 35 patients with 87 zygomatic implants were included. The mean follow-up period of the patients was 93 months. The zygomatic implant survival and complications were evaluated as criteria for success.There were no implant failures. Overall success rate without complications for zygomatic implant was 88.5%. Complications developed in 4 patients (1 cutaneous fistula and 3 mucositis). According to the results on an implant basis, patients with previously failed conventional implants had greater probability of complications. Patients with quad zygomatic implants had higher incidence of complications than those with two zygomatic implants. Fully threaded implant design was associated with higher incidence of mucositis than partially threaded design. No relation was found between implant success and smoking, prosthesis type, and antagonist dentition. When conducting the analysis using the patient as unit, only the antagonist dentition showed significant difference, the worst outcome being associated with the Toronto resin prosthesis.Zygomatic implants can be considered as a safe alternative to conventional implant insertions and bone grafting procedures in oral rehabilitation of patients with severely atrophic maxillary bone.

Published
2023

22. Sub-barrier fusion in C12+Mg26,24 : Hindrance and oscillations

Author

Stefanini, A. M., Montagnoli, G., Del Fabbro, M., Brugnara, D., Colucci, G., Corradi, L., Diklić, J., Fioretto, E., Galtarossa, F., Goasduff, A., Mazzocco, M., Pellumaj, J., Pilotto, E., Zago, L., and Zanon, I.

Subjects
Nuclear Physics, Heavy ion reactions, sub barrier fusion, Heavy ion reactions, sub barrier fusion, Nuclear Physics
Published
2023

23. Arduino Automated Microwave Oven for Tissue Decalcification

Author

Savadori, P., Dalfino, S., Piazzoni, M., Inchingolo, F., Del Fabbro, M., Tartaglia, G.M., and Giardino, L.

Subjects
Settore BIO/17 - Istologia, Arduino, bone, decalcification, microwaves, teeth, Settore MED/28 - Malattie Odontostomatologiche, Settore MED/50 - Scienze Tecniche Mediche Applicate
Published
2023

24. Oral rehabilitation with unilateral zygomatic implants: A case series of 32 patients

Author

Goker, F., Grecchi, E., Del Fabbro, M., Tedesco, A., Borgonovo, A., Bedendo, A., and Grecchi, F.

Subjects
unilateral zygomatic implants, Dental Implants, Zygoma, maxillary rehabilitation, oral rehabilitation, partially edentulous atrophic maxilla, zygomatic implants, Aged, Dental Implantation, Endosseous, Dental Prosthesis, Implant-Supported, Humans, Middle Aged, Retrospective Studies, Treatment Outcome, Jaw, Edentulous, Settore MED/50 - Scienze Tecniche Mediche Applicate, Implant-Supported, Edentulous, Settore MED/29 - Chirurgia Maxillofacciale, Dental Prosthesis, Dental Implantation, Jaw, Settore MED/28 - Malattie Odontostomatologiche, Endosseous
Abstract

Zygomatic implants are successful alternatives to conventional dental implants for oral rehabilitation of patients with severely atrophic maxillae; however, the use of unilateral zygomatic implants needs to be studied further to validate their efficacy. The present investigation aimed to evaluate unilateral zygomatic implant placement in the oral rehabilitation of partially edentulous patients with extremely atrophic maxillary bone and/or previous implant failures.This retrospective clinical study included patients with partially edentulous maxillae who underwent unilateral zygomatic implant insertion. The primary outcome was implant survival. Intraoperative, postoperative and prosthetic complications were also assessed based on patients' clinical records.A total of 32 patients (34 zygomatic implants) with a mean age of 60.45 ± 8.74 years (range 47 to 78 years) were included in the study. The mean follow-up period was 34.3 ± 25.5 months, and the overall implant survival rate was 100%. No intraoperative or postoperative complications developed in any of the patients, and no prosthesis failures or complications were recorded.The results indicate that unilateral zygomatic implant insertion for oral rehabilitation of patients with partially edentulous posterior maxillae with severely atrophic bone and/or previous implant failures can be considered a successful alternative to use of conventional dental implants associated with advanced bone grafting procedures.

Published
2022

25. Cone-beam computed tomography accuracy in pulp chamber size evaluation: An ex vivo study

Author

Maddalone, M, Citterio, C, Pellegatta, A, Gagliani, M, Karanxha, L, Del Fabbro, M, Maddalone M., Citterio C., Pellegatta A., Gagliani M., Karanxha L., Del Fabbro M., Maddalone, M, Citterio, C, Pellegatta, A, Gagliani, M, Karanxha, L, Del Fabbro, M, Maddalone M., Citterio C., Pellegatta A., Gagliani M., Karanxha L., and Del Fabbro M.

Abstract

This study aimed to assess ex vivo the accuracy of cone-beam computed tomography (CBCT), as compared to operative microscope, for evaluating pulp chamber size. A total of forty teeth were extracted for periodontal reasons and a horizontal section was done at the most apical level of the cement–enamel junction. The pulp chamber was photographed using a digital camera connected to an optical microscope. Then, the tooth was scanned with CBCT and the horizontal slide matching the anatomical section of pulp chamber was digitally stored. The pulp chamber section area was measured through image analysis software. The two methods provided similar results, either for monoradicular (P = 0.14) or multiradicular teeth (P = 0.93). Correlation was statistically significant (P < 0.0001), being the coefficient r = 0.89 and 0.94 for monoradicular and multiradicular teeth, respectively. Conclusively, CBCT is suitable for pulp chamber morphology evaluation. However, it has limitations in detecting the anatomical variability of small branches in root canal system.

Published
2020

26. Post-Operative Patients' Satisfaction and Quality of Life Assessment in Adult Patients with Obstructive Sleep Apnea Syndrome (OSAS)

Author

Rossi, D.S., Goker, F., Cullati, F., Baj, A., Pignatelli, D., Gianni, A.B., and Del Fabbro, M.

Subjects
Adult, Sleep Apnea, Obstructive, Sleep Apnea, Obstructive, Orthognathic Surgical Procedures, orthognathic surgery, bi-maxillary surgery, Settore MED/50 - Scienze Tecniche Mediche Applicate, OSAS, Settore MED/29 - Chirurgia Maxillofacciale, Sleep Apnea Syndromes, maxillomandibular advancement surgery, Humans, Patient Satisfaction, Quality of Life, Settore MED/28 - Malattie Odontostomatologiche
Abstract

The treatment for severe OSAS includes maxillomandibular advancement surgical option in selected cases. The aim of this study was to evaluate the post-operative impact of bimaxillary surgery on satisfaction and consequently the quality of life of these patients.This study included 18 patients with severe OSAS who received maxillomandibular advancement surgery. Patients were divided into Group A (operated by CAD/CAM) and Group B (conventional surgery). The impact of bimaxillary surgery on satisfaction and quality of life of these patients was evaluated by utilizing post-operative life quality and Rustemeyer's patient-satisfaction-based survey.A total of 18 adult OSAS patients (Group A: 11 patients, Group B: 7 patients) with a mean age of 44.39 years (SD ± 9.43) were included. Mean follow-up period was 32.64 months (SD ± 21.91). No intra-operative complications were seen in any patients. Post-operative complication was seen in one patient and the mandible did not integrate. According to the results, overall post-operative satisfaction score was 79.72% (SD ± 9.96). There was no significant difference among those in Group A and Group B.Maxillomandibular advancement surgery seems to be beneficial in terms of patients' satisfaction in severe adult OSAS patients and can be considered as a valuable option in selected cases.

Published
2022

27. Long-Term Results of Intraforaminal Immediately Loaded Implants and Posterior Mandibular Regrowth Evaluation in Severely Atrophic Mandibles

Author

Testori, T., Clauser, T., Scaini, R., Wang, H., and Del Fabbro, M.

Subjects
Dental Implants, Male, immediate implant loading, Settore MED/50 - Scienze Tecniche Mediche Applicate, Dental Implantation, Endosseous, Alveolar Bone Loss, implant survival, General Medicine, Alveolar Ridge Augmentation, Mandible, atrophic mandibles, Implant-Supported, Dental Prosthesis Design, Dental Prosthesis, Implant-Supported, Dental Restoration Failure, Female, Follow-Up Studies, Humans, Treatment Outcome, Dental Prosthesis, Dental Implantation, Settore MED/28 - Malattie Odontostomatologiche, Oral Surgery, Endosseous
Abstract

The aim of this clinical study was to verify the predictability of the rehabilitation of extremely atrophic jaws with immediately loaded short implants and evaluate posterior mandibular regrowth.A cohort of consecutive fully edentulous patients wearing complete dentures in both arches was enrolled. Periodically, implant survival and prosthetic success were assessed. After informed consent, a subsample of 10 patients who had preoperative CBCT underwent a postoperative CBCT 1 year after immediate implant loading, and 3D superimpositions of pre- and postoperative images were performed. Linear measurements of bone height were performed at two sites in each hemimandible and, on the same sections, bone density according to the qualitative gray values (GVs) was analyzed in an area of 3 mmFifty-nine fully edentulous patients (31 females, 28 males) with Class VI atrophic mandibles according to Cawood and Howell were rehabilitated with the insertion of four to five short implants (4-mm diameter, 7- or 8.5-mm long). Overall, 251 implants were immediately loaded with a fixed hybrid prosthesis. Four patients did not show up for recall visits, bringing the final number down to 55 patients (31 females, 24 males) and 231 implants. In up to 14 years of follow-up, a total of 4 implant failures were recorded (cumulative survival rate, 98.4%). The biologic complications included 9 mucositis (3.9%) and 3 peri-implantitis (1.3%) at implant-level analysis. Mechanical complications involved 9 chippings of the prosthetic restorations (17.0%). In the 10-patient subsample, the analysis showed bone growth (average of 1.2 ± 0.7 mm) in the posterior areas of the mandible. In addition, bone density was found to increase 17% to 27% with reference to the preoperative CBCT.The immediate loading of short implants may represent a feasible therapeutic option for the treatment of fully edentulous patients with severely atrophic mandibles. Bone regrowth in the posterior areas and an increase in bone density of the mandible may occur.

Published
2022

31. Zygomatic implant-guided rehabilitation based on inverted support technique: a pilot study.

Author

BOLZONI, A. R., ZINGARI, F., GALLO, F., GOKER, F., BERETTA, P., DEL FABBRO, M., MORTELLARO, C., GRECCHI, F., and GIANNÌ, A. B.

Abstract

OBJECTIVE: Zygomatic implant insertion surgery is a challenging operation. The primary aim of this pilot study was to assess the accuracy of EZgoma® "Inverted Support Technique" for the zygomatic implant-guided surgery. Secondly, any factors which may affect the surgical protocol results, such as implant-prosthetic virtual plan, surgical model matching, intra or post-operative complications, time rate between surgical procedure and prosthetic loading, zygomatic implant survival rate and implant success rate were analyzed. PATIENTS AND METHODS: A total of 20 zygomatic implants were placed in atrophic maxillae of 5 patients. The final position of zygomatic implants after surgery was compared with the pre-operative digitally planned position. The analyzed parameters were zygomatic implants apex and base mean linear distance and zygomatic implants axis mean angular deviation. RESULTS: The comparison was provided by a tridimensional imaging elaboration platform, provided by Geomagic, which allows the overlay of virtual plan STL data with post-operative control CT scan DICOM data. As a result, all the mean values regarding the 20 placed zygomatic implants respected the universally agreed values in guided zygomatic implant surgery: the mean linear distance of the implant platform and of the implant apex were 1.59 mm and 1.62 mm respectively, while the mean angular deviation of the implant axis was equal to 1.74°. One of the patients had mucositis as a post-operative complication. In one patient the anterior wall of the maxillary sinus fractured, and in one zygomatic implant primary stabilization was not achieved. No other complications occurred. CONCLUSIONS: As a conclusion, data obtained from this study suggested that guided zygomatic implant rehabilitation may represent a reliable, efficient, rapid, ergonomie, and safe surgical protocol, however further investigations are needed. [ABSTRACT FROM AUTHOR]

Published
2023

32. Clinical and histopathological profile of oral cancer: a quadrennial analysis of Regional Cancer Centre of Odisha, India.

Author

PANDA, S., PANDA, SAS., MOHANTY, N., GIACOMELLO, M., COLLETTI, L., CORRADINI, C., LUCCHINA, A. GRECO, GOKER, F., MORTELLARO, C., DEL FABBRO, M., and PANDA, SAU.

Abstract

OBJECTIVE: To contribute toward the identification of population-based clinical and histopathological profile of oral squamous cell carcinoma (OSCC), this study was undertaken at the Regional Cancer Centre of Odisha (AHRCC), India. PATIENTS AND METHODS: This retrospective study included all patients diagnosed with OSCC registered at AHRCC, Odisha from 1st January 2015 to 31st December 2018. Demographic, clinical, and pathological data of each patient were retrieved from patient records. Patients with incomplete records were excluded. No postoperative treatment details were collected. RESULTS: The study included 851 cases of OSCC with the mean age of the population found to be 53.8±14.2 years. Male to female ratio was found to be 2.18:1. Gingivobuccal complex was the most common site of OSCC. While 679 patients were reported to undergo incision biopsy only 172 patients underwent excision biopsy in four years. Well differentiation (n=782) is the most common histological grading. The median clinical size of the tumour was 4 cm. Upon analyzing histological parameters in excision specimens lymphovascular and perineural invasion were seen in 38 and 26 cases, respectively. Cervical lymph node metastasis was seen in 42 cases out of 172 excision specimens (24%). 63.23% of cases presented with a depth of invasion between 5 to 10 mm. CONCLUSIONS: This is the largest comprehensive data from the regional cancer center of Odisha population which highlights the demographic, clinical, and histopathological data reported to date. [ABSTRACT FROM AUTHOR]

Published
2023

33. Optical coherence tomography application for assessing variation in bone mineral content: a preclinical study.

Author

KHIJMATGAR, S., PANDA, S., BIAGI, R., ROVATI, M., COLLETTI, L., GOKER, F., LUCCHINA, A. GRECO, MORTELLARO, C., and DEL FABBRO, M.

Abstract

OBJECTIVE: Optical Coherence Tomography (OCT) is a non-invasive imaging technique that produces cross-sectional images through biological tissues, allowing three-dimensional reconstruction and analysis. Aim was to evaluate if OCT may discriminate among tissues with different bone density and composition, by measuring the depth of light penetration in porcine and rat bone samples. MATERIALS AND METHODS: Two carpal bone samples (2 cm length) were harvested from the porcine forelimb and fixed overnight in 3.7% buffered formal saline. Following fixation, one sample was decalcified in a 1:1 mixture of 8% hydrochloric acid and 8% formic acid solution for three days, with solution changes each day. Samples were imaged using an OCT microscope. Furthermore, the calvaria, ulnar, alveolar and basal bone of mandible of 6 male and 6 female rats were cleared of overlying soft tissues and scanned under OCT. The light penetration depth in each sample was measured using the software Image J, and Scattering Attenuation Microscopy. RESULTS: In the mineralized bone the average depth (µm) and standard deviation (SD) of light penetration were 790.1±18.05 and 410.4±21.7 for periosteal and endosteal surface, respectively, and 507.3±21.03 for cross-section surfaces, while it was 858.4±32.03 for periosteal surface, 1150±26.9 for endosteal, and 627.3±31.8 for cross-section bone surfaces in demineralized porcine bone. There was a significant difference (p<0.001) in depth of light penetration between normal and de-mineralized bone for all regions evaluated. No systematic significant difference in light penetration depth between-gender was found at any site evaluated, while there were variations between sites (p<0.001). The OCT detected differences in bone mineral and porosity among gender (p<0.0001) CONCLUSIONS: This study suggests that OCT may represent a valuable technique to estimate local variations in bone mineral content. [ABSTRACT FROM AUTHOR]

Published
2023

34. 3D Computed Tomography vs. 2D radiography: comparison of 3D direct anthropometry with 2D norm calculations and analysis of differences in soft tissue measurements.

Author

PERROTTI, G., GOKER, F., ROSSI, O., NOWAKOWSKA, J., RUSSILLO, A., BELTRAMINI, G., TARTAGLIA, G. M., TESTORI, T., DEL FABBRO, M., and MORTELLARO, C.

Abstract

OBJECTIVE: The aim of this study was twofold: (1) to compare soft tissue measurements of the same distances obtained from 3D computed tomography reconstructions with 2D cephalometric radiograms, (2) to compare data from 3D measurements from direct anthropometry and 2D "norms" for the facial measurements. PATIENTS AND METHODS: A total of 40 Caucasian patients that had their CBCT scans for various dental and dentoskeletal reasons were enrolled in this study. All the patients had large field of view (from the forehead to the chin). The data were stored in DICOM format and imported into a software for 3D reconstructions. After 3D facial soft tissue model generation, the distances between 18 soft tissue points were measured. The 3D soft tissue analysis was performed, and the facial indices were calculated. The mean 3D values were compared with 2D measurements performed on lateral cephalograms and Arnett's and Farkas' norms. The measurements were statistically compared using Student's f-test. RESULTS: Assessments from 2D and 3D mea-surements showed no statistical difference except for the distance Pogonion (for both male and female) and Labial superius prominence (females) to the True Vertical Line in 2D /Plane in case of 3D measurements. There was a significant difference between all 3D measurements and Arnett's and anthropometric Farkas' "norms". The mean difference between Farkas' "norms" and 3D measurements was within 3 mm for 70% of measurements. CONCLUSIONS: According to the results, 3D soft tissue analysis allows for complete diagnostic determination. The 3D "norms" are to be verified on a greater sample. [ABSTRACT FROM AUTHOR]

Published
2023

38. Role of probiotics in adjunct to non-surgical periodontal therapy in patients with chronic periodontitis: a systematic review and meta-analysis

Author

Mishra, S, Misra, SR, Panda, S, Mohanty, N, Manfredi, B, Parrini, M, Giacomello, MS, Mortellaro, C, Lucchina, AG, Annunziata, M, Del Fabbro, M, Mishra, S, Misra, Sr, Panda, S, Mohanty, N, Manfredi, B, Parrini, M, Giacomello, M, Mortellaro, C, Lucchina, Ag, Annunziata, M, and Del Fabbro, M

Subjects
systematic review, clinical attachment level, meta-analysi, periodontal probing depth, probiotic, chronic periodontiti
Abstract

The objective of this study was to establish the significance of probiotic usage, both as a preventive as well as a therapeutic strategy for the management of periodontal disease. It also substantiates the existing studies of single/combined bacterial strain for exhibiting variable ecological impact on oral bacteria. Data sources included literature searches of PubMed (MEDLINE), Scopus, Embase, CENTRAL and Web of science databases for placebo controlled randomized clinical trials of SRP with orally administered probiotics in any form as an adjunct. Data extraction was conducted and information from the included studies was tabulated according to the study designs, form of drug delivery, main outcomes, and clinical parameters. Data collected were based on the focused question outlined for the present systematic review. The reviewers cross-checked all extracted data. CAL and PD were assessed as the primary outcome to compare the effectiveness of adjunctive probiotic therapy in addition to SRP. Fourteen clinical studies were included and demonstrated efficacy in reducing periodontal probing depth (PPD) and gaining clinical attachment level (CAL), between probiotics and SRP/placebo. Adjunctive probiotic therapy in addition to SRP leads to decrease in probing depth and clinical attachment gain in chronic periodontitis patients. However, further high-quality randomized clinical trials with microbiological outcomes are required to fortify the conclusion.

Published
2021

39. Efficacy of locally delivered statins as an adjunct to scaling and root planing in the treatment of periodontitis: a systematic review and meta-analysis

Author

Cecoro, G, Piccirillo, A, Martuscelli, G, Del Fabbro, M, Annunziata, M, Guida, L, Cecoro, G, Piccirillo, A, Martuscelli, G, Del Fabbro, M, Annunziata, M, and Guida, L

Subjects
Trial sequential analysts, Periodontiti, Non-surgical periodontal therapy, Statin, Meta-analysi
Abstract

OBJECTIVE: The aim of this systematic review is to assess the efficacy of locally delivered statins used in adjunct to scaling and root planing (SRP), compared with SRP alone.MATERIALS AND METHODS: An electronic and hand search was carried out up to April 2020. Only randomized controlled trials (RCTs) were included. Clinical attachment level gain (CALgain) and probing depth reduction (PDred), modified sulcular bleeding index reduction (mSBlred), and intrabony defect reduction (IBDred) were the investigated outcomes. Meta-analysis was performed, and the power of the meta-analytic findings was determined by trial sequential analysis (TSA). Studies were also sub-grouped based on the type of statin used. Statistical heterogeneity and publication bias were assessed.RESULTS: Twenty RCTs were included (1212 patients, 1289 defects). An overall statistically significant effect size in favor of statins for CALgain and PDred was found. As opposed to atorvastatin and rosuvastatin, simvastatin did not reach statistical significance for these outcomes, as shown by the sub-group analysis.CONCLUSIONS: Within the limits of the available studies, the local administration of statins (in particular, atorvastatin and rosuvastatin) in adjunct to SRP may result in additional significant improvement in terms of CALgain and PDred compared with SRP alone. The high heterogeneity of data and the high risk of bias found, however, impose caution. No approved preparations, moreover, exist, and further well-designed RCTs from independent research centers are needed to confirm the beneficial effects of the different statins and their mutual differences in the non-surgical periodontal treatment.

Published
2021

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