530 results on '"Dekker, Frank"'
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2. Impact of HDAC inhibitors on macrophage polarization to enhance innate immunity against infections
3. The synthesis of 1,2,3-triazoles as binders of D-dopachrome tautomerase (D-DT) for the development of dual-targeting inhibitors
4. Discovery of highly potent HDAC8 PROTACs with anti-tumor activity
5. Discovery of chromene compounds as inhibitors of PvdQ acylase of Pseudomonas aeruginosa
6. Blocking MIF secretion enhances CAR T-cell efficacy against neuroblastoma
7. Acetylation and Methylation in Asthma, COPD, and Lung Cancer
8. HDAC/MIF dual inhibitor inhibits NSCLC cell survival and proliferation by blocking the AKT pathway
9. Epigenetic regulation in macrophage migration inhibitory factor (MIF)-mediated signaling in cancer and inflammation
10. Exploration of Hydrazide-Based HDAC8 PROTACs for the Treatment of Hematological Malignancies and Solid Tumors.
11. Small Molecule MIF Modulation Enhances Ferroptosis by Impairing DNA Repair Mechanisms.
12. Induced protein degradation of histone deacetylases 3 (HDAC3) by proteolysis targeting chimera (PROTAC)
13. The genetics of asthma and the promise of genomics-guided drug target discovery
14. Structure-activity relationships for binding of 4-substituted triazole-phenols to macrophage migration inhibitory factor (MIF)
15. Macrophage migration inhibitory factor family proteins are multitasking cytokines in tissue injury
16. Light-controlled inhibition of BRAFV600E kinase
17. Inhibitory selectivity among class I HDACs has a major impact on inflammatory gene expression in macrophages
18. A combinatorial approach for the discovery of drug-like inhibitors of 15-lipoxygenase-1
19. Identification of potential antivirulence agents by substitution-oriented screening for inhibitors of Streptococcus pyogenes sortase A
20. Identification and characterization of a small molecule that activates thiosulfate sulfurtransferase and stimulates mitochondrial respiration
21. Small-molecule inhibitors of macrophage migration inhibitory factor (MIF) as an emerging class of therapeutics for immune disorders
22. Discovery of chromenes as inhibitors of macrophage migration inhibitory factor
23. Histone Deacetylase 3‐Directed PROTACs Have Anti‐inflammatory Potential by Blocking Polarization of M0‐like into M1‐like Macrophages
24. Photoactivation provides a mechanistic explanation for pan-assay interference behaviour of 2-aminopyrroles in lipoxygenase inhibition
25. The relevance of Ki calculation for bi-substrate enzymes illustrated by kinetic evaluation of a novel lysine (K) acetyltransferase 8 inhibitor
26. A 6-alkylsalicylate histone acetyltransferase inhibitor inhibits histone acetylation and pro-inflammatory gene expression in murine precision-cut lung slices
27. Towards the development of activity-based probes for detection of lysine-specific demethylase-1 activity
28. Acetylation and Methylation in Asthma, COPD, and Lung Cancer
29. Allosteric Inhibitors of Macrophage Migration Inhibitory Factor (MIF) Interfere with Apoptosis-Inducing Factor (AIF) Co-Localization to Prevent Parthanatos
30. Protocol of the Double‐Click Seq Method to Evaluate the Deposition Bias of Chromatin Proteins
31. First-in-Class Selective Inhibitors of the Lysine Acetyltransferase KAT8
32. Rational Design in Photopharmacology with Molecular Photoswitches
33. Design of a novel thiophene inhibitor of 15-lipoxygenase-1 with both anti-inflammatory and neuroprotective properties
34. De Hoge Raad zet de wekker op 20 juli 2018, óók voor (semi-)diepslapers en verlate slapers
35. Discovery of Highly Potent Hdac8 Protacs with Anti-Tumor Activity
36. Ruthenium complexes as inhibitors of 15-lipoxygenase-1
37. Enzyme kinetics and inhibition of histone acetyltransferase KAT8
38. Identification of 6-benzyloxysalicylates as a novel class of inhibitors of 15-lipoxygenase-1
39. A dual inhibitor of matrix metalloproteinases and a disintegrin and metalloproteinases, [18F]FB-ML5, as a molecular probe for non-invasive MMP/ADAM-targeted imaging
40. The degradation of nucleotide triphosphates extracted under boiling ethanol conditions is prevented by the yeast cellular matrix
41. Delivery of epidrugs
42. Small molecule inhibitors of histone acetyltransferases and deacetylases are potential drugs for inflammatory diseases
43. Integration of a cooling water outflow in the Rotterdam harbour extension
44. Site-specific quantification of lysine acetylation in the N-terminal tail of histone H4 using a double-labelling, targeted UHPLC MS/MS approach
45. Novel Design Strategies to Enhance the Efficiency of Proteolysis Targeting Chimeras
46. Discovery of a novel activator of 5-lipoxygenase from an anacardic acid derived compound collection
47. Catalytic asymmetric total synthesis of (S)-(−)-zearalenone, a novel lipoxygenase inhibitor
48. Anacardic acid derived salicylates are inhibitors or activators of lipoxygenases
49. 6-alkylsalicylates are selective Tip60 inhibitors and target the acetyl-CoA binding site
50. Small Molecule Inhibitors of Histone Deacetylases and Acetyltransferases as Potential Therapeutics in Oncology
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