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496 results on '"Dejong, Cornelis H C"'

1. Intersurgeon Variability in Local Treatment Planning for Patients with Initially Unresectable Colorectal Cancer Liver Metastases: Analysis of the Liver Expert Panel of the Dutch Colorectal Cancer Group

Author

Bond, Marinde J. G., Kuiper, Babette I., Bolhuis, Karen, Komurcu, Aysun, van Amerongen, Martinus J., Chapelle, Thiery, Dejong, Cornelis H. C., Engelbrecht, Marc R. W., Gerhards, Michael F., Grünhagen, Dirk J., van Gulik, Thomas, Hermans, John J., de Jong, Koert P., Klaase, Joost M., Kok, Niels F. M., Leclercq, Wouter K. G., Liem, Mike S. L., van Lienden, Krijn P., Molenaar, I. Quintus, Neumann, Ulf P., Patijn, Gijs A., Rijken, Arjen M., Ruers, Theo M., Verhoef, Cornelis, de Wilt, Johannes H. W., Kazemier, Geert, May, Anne M., Punt, Cornelis J. A., and Swijnenburg, Rutger-Jan

Published
2023
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3. The Prognostic Value of Total Tumor Volume Response Compared With RECIST1.1 in Patients With Initially Unresectable Colorectal Liver Metastases Undergoing Systemic Treatment

Author

Wesdorp, Nina J., Bolhuis, Karen, Roor, Joran, van Waesberghe, Jan-Hein T. M., van Dieren, Susan, van Amerongen, Martin J., Chapelle, Thiery, Dejong, Cornelis H. C., Engelbrecht, Marc R. W., Gerhards, Michael F., Grunhagen, Dirk, van Gulik, Thomas M., Hermans, John J., de Jong, Koert P., Klaase, Joost M., Liem, Mike S. L., van Lienden, Krijn P., Molenaar, I. Quintus, Patijn, Gijs A., Rijken, Arjen M., Ruers, Theo M., Verhoef, Cornelis, de Wilt, Johannes H. W., Swijnenburg, Rutger-Jan, Punt, Cornelis J. A., Huiskens, Joost, and Kazemier, Geert

Published
2021
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4. Endoscopic versus percutaneous biliary drainage in patients with resectable perihilar cholangiocarcinoma: a multicentre, randomised controlled trial

Author

Coelen, Robert J S, Roos, Eva, Wiggers, Jimme K, Besselink, Marc G, Buis, Carlijn I, Busch, Olivier R C, Dejong, Cornelis H C, van Delden, Otto M, van Eijck, Casper H J, Fockens, Paul, Gouma, Dirk J, Koerkamp, Bas Groot, de Haan, Michiel W, van Hooft, Jeanin E, IJzermans, Jan N M, Kater, G Matthijs, Koornstra, Jan J, van Lienden, Krijn P, Moelker, Adriaan, Damink, Steven W M Olde, Poley, Jan-Werner, Porte, Robert J, de Ridder, Rogier J, Verheij, Joanne, van Woerden, Victor, Rauws, Erik A J, Dijkgraaf, Marcel G W, and van Gulik, Thomas M

Published
2018
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5. Short-Term Outcomes of Secondary Liver Surgery for Initially Unresectable Colorectal Liver Metastases Following Modern Induction Systemic Therapy in the Dutch CAIRO5 Trial

Author

Bolhuis, Karen, Grosheide, Lodi, Wesdorp, Nina J., Komurcu, Aysun, Chapelle, Thiery, Dejong, Cornelis H. C., Gerhards, Michael F., Grünhagen, Dirk J., van Gulik, Thomas M., Huiskens, Joost, De Jong, Koert P., Kazemier, Geert, Klaase, Joost M., Liem, Mike S. L., Molenaar, I. Quintus, Patijn, Gijs A., Rijken, Arjen M., Ruers, Theo M., Verhoef, Cornelis, de Wilt, Johannes H. W., Punt, Cornelis J. A., and Swijnenburg, Rutger-Jan

Published
2021
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8. ASO Visual Abstract: Intersurgeon Variability in Local Treatment Planning for Patients with Initially Unresectable Colorectal Cancer Liver Metastases—Analysis of the Liver Expert Panel of the Dutch Colorectal Cancer Group

Author

Bond, Marinde J. G., primary, Kuiper, Babette I., additional, Bolhuis, Karen, additional, Komurcu, Aysun, additional, van Amerongen, Martinus J., additional, Chapelle, Thiery, additional, Dejong, Cornelis H. C., additional, Engelbrecht, Marc R. W., additional, Gerhards, Michael F., additional, Grünhagen, Dirk J., additional, van Gulik, Thomas, additional, Hermans, John J., additional, de Jong, Koert P., additional, Klaase, Joost M., additional, Kok, Niels F. M., additional, Leclercq, Wouter K. G., additional, Liem, Mike S. L., additional, van Lienden, Krijn P., additional, Quintus Molenaar, I., additional, Neumann, Ulf P., additional, Patijn, Gijs A., additional, Rijken, Arjen M., additional, Ruers, Theo M., additional, Verhoef, Cornelis, additional, de Wilt, Johannes H. W., additional, Kazemier, Geert, additional, May, Anne M., additional, Punt, Cornelis J. A., additional, and Swijnenburg, Rutger-Jan, additional

Published
2023
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12. Immediate versus postponed intervention for infected necrotizing pancreatitis

Author

Boxhoorn, Lotte, van Dijk, Sven M., van Grinsven, Janneke, Verdonk, Robert C., Boermeester, Marja A., Bollen, Thomas L., Bouwense, Stefan A. W., Bruno, Marco J., Cappendijk, Vincent C., Dejong, Cornelis H. C., van Duijvendijk, Peter, van Eijck, Casper H. J., Fockens, Paul, Francken, Michiel F. G., van Goor, Harry, Hadithi, Muhammed, Hallensleben, Nora D. L., Haveman, Jan Willem, Jacobs, Maarten A. J. M., Jansen, Jeroen M., Kop, Marnix P. M., van Lienden, Krijn P., Manusama, Eric R., Mieog, Sven J. D., Molenaar, I. Quintus, Nieuwenhuijs, Vincent B., Poen, Alexander C., Poley, Jan-Werner, van de Poll, Marcel, Quispel, Rutger, Römkens, Tessa E. H., Schwartz, Matthijs P., Seerden, Tom C., Stommel, Martijn W. J., Straathof, Jan Willem A., Timmerhuis, Hester C., Venneman, Niels G., Voermans, Rogier P., van de Vrie, Wim, Witteman, Ben J., Dijkgraaf, Marcel G. W., van Santvoort, Hjalmar C., Besselink, Marc G., Study group members AMC, Stoker, Jaap, Gastroenterology & Hepatology, Surgery, Gastroenterology and Hepatology, Graduate School, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Radiology and Nuclear Medicine, Epidemiology and Data Science, APH - Methodology, MUMC+: MA Heelkunde (9), RS: NUTRIM - R2 - Liver and digestive health, Intensive Care, and MUMC+: MA Medische Staf IC (9)

Subjects
medicine.medical_specialty, MEDLINE, Disease, CLASSIFICATION, law.invention, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], Randomized controlled trial, law, Intervention (counseling), Catheter drainage, MANAGEMENT, Medicine, Combined Modality Therapy, STEP-UP APPROACH, OUTCOMES, business.industry, NECROSIS, General Medicine, NECROSECTOMY, medicine.disease, digestive system diseases, Surgery, Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10], Pancreatitis, business, Necrotizing pancreatitis
Abstract

Item does not contain fulltext BACKGROUND: Infected necrotizing pancreatitis is a potentially lethal disease that is treated with the use of a step-up approach, with catheter drainage often delayed until the infected necrosis is encapsulated. Whether outcomes could be improved by earlier catheter drainage is unknown. METHODS: We conducted a multicenter, randomized superiority trial involving patients with infected necrotizing pancreatitis, in which we compared immediate drainage within 24 hours after randomization once infected necrosis was diagnosed with drainage that was postponed until the stage of walled-off necrosis was reached. The primary end point was the score on the Comprehensive Complication Index, which incorporates all complications over the course of 6 months of follow-up. RESULTS: A total of 104 patients were randomly assigned to immediate drainage (55 patients) or postponed drainage (49 patients). The mean score on the Comprehensive Complication Index (scores range from 0 to 100, with higher scores indicating more severe complications) was 57 in the immediate-drainage group and 58 in the postponed-drainage group (mean difference, -1; 95% confidence interval [CI], -12 to 10; P = 0.90). Mortality was 13% in the immediate-drainage group and 10% in the postponed-drainage group (relative risk, 1.25; 95% CI, 0.42 to 3.68). The mean number of interventions (catheter drainage and necrosectomy) was 4.4 in the immediate-drainage group and 2.6 in the postponed-drainage group (mean difference, 1.8; 95% CI, 0.6 to 3.0). In the postponed-drainage group, 19 patients (39%) were treated conservatively with antibiotics and did not require drainage; 17 of these patients survived. The incidence of adverse events was similar in the two groups. CONCLUSIONS: This trial did not show the superiority of immediate drainage over postponed drainage with regard to complications in patients with infected necrotizing pancreatitis. Patients randomly assigned to the postponed-drainage strategy received fewer invasive interventions. (Funded by Fonds NutsOhra and Amsterdam UMC; POINTER ISRCTN Registry number, ISRCTN33682933.).

Published
2021

16. Interobserver Variability in CT-based Morphologic Tumor Response Assessment of Colorectal Liver Metastases

Author

Wesdorp, Nina J, Kemna, Ruby, Bolhuis, Karen, van Waesberghe, Jan H T M, Nota, Irene M G C, Struik, Femke, Oulad Abdennabi, Ikrame, Phoa, Saffire S K S, van Dieren, Susan, van Amerongen, Martinus J, Chapelle, Thiery, Dejong, Cornelis H C, Engelbrecht, Marc R W, Gerhards, Michael F, Grünhagen, Dirk, van Gulik, Thomas M, Hermans, John J, de Jong, Koert P, Klaase, Joost M, Liem, Mike S L, van Lienden, Krijn P, Molenaar, I Quintus, Patijn, Gijs A, Rijken, Arjen M, Ruers, Theo M, Verhoef, Cornelis, de Wilt, Johannes H W, Swijnenburg, Rutger-Jan, Punt, Cornelis J A, Huiskens, Joost, Stoker, Jaap, Kazemier, Geert, Surgery, MUMC+: MA Heelkunde (9), RS: NUTRIM - R2 - Liver and digestive health, Internal medicine, Radiology and nuclear medicine, AGEM - Re-generation and cancer of the digestive system, VU University medical center, CCA - Imaging and biomarkers, Radiology & Nuclear Medicine, Graduate School, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Radiology and Nuclear Medicine, AGEM - Digestive immunity, APH - Methodology, Oncology, Groningen Institute for Organ Transplantation (GIOT), Guided Treatment in Optimal Selected Cancer Patients (GUTS), and Value, Affordability and Sustainability (VALUE)

Subjects
Colorectal Neoplasms/diagnostic imaging, Male, Tumor Response, Abdomen/Gastrointestinal, Tomography, X-Ray Computed/methods, Observer Performance, Metastases, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], Liver Neoplasms/diagnostic imaging, Humans, Prospective Studies, Tomography, Original Research, Computer. Automation, Observer Variation, Liver Neoplasms, General Medicine, Middle Aged, X-Ray Computed/methods, Liver, Oncology, Female, Human medicine, Colorectal Neoplasms, Tomography, X-Ray Computed, Rare cancers Radboud Institute for Health Sciences [Radboudumc 9], CT
Abstract

Item does not contain fulltext Purpose To evaluate interobserver variability in the morphologic tumor response assessment of colorectal liver metastases (CRLM) managed with systemic therapy and to assess the relation of morphologic response with gene mutation status, targeted therapy, and Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1 measurements. Materials and Methods Participants with initially unresectable CRLM receiving different systemic therapy regimens from the randomized, controlled CAIRO5 trial (NCT02162563) were included in this prospective imaging study. Three radiologists independently assessed morphologic tumor response on baseline and first follow-up CT scans according to previously published criteria. Two additional radiologists evaluated disagreement cases. Interobserver agreement was calculated by using Fleiss κ. On the basis of the majority of individual radiologic assessments, the final morphologic tumor response was determined. Finally, the relation of morphologic tumor response and clinical prognostic parameters was assessed. Results In total, 153 participants (median age, 63 years [IQR, 56-71]; 101 men) with 306 CT scans comprising 2192 CRLM were included. Morphologic assessment performed by the three radiologists yielded 86 (56%) agreement cases and 67 (44%) disagreement cases (including four major disagreement cases). Overall interobserver agreement between the panel radiologists on morphology groups and morphologic response categories was moderate (κ = 0.53, 95% CI: 0.48, 0.58 and κ = 0.54, 95% CI: 0.47, 0.60). Optimal morphologic response was particularly observed in patients treated with bevacizumab (P = .001) and in patients with RAS/BRAF mutation (P = .04). No evidence of a relationship between RECIST 1.1 and morphologic response was found (P = .61). Conclusion Morphologic tumor response assessment following systemic therapy in participants with CRLM demonstrated considerable interobserver variability. Keywords: Tumor Response, Observer Performance, CT, Liver, Metastases, Oncology, Abdomen/Gastrointestinal Clinical trial registration no. NCT02162563 Supplemental material is available for this article. © RSNA, 2022.

Published
2022

18. Combined Quantitative (Phospho)proteomics and Mass Spectrometry Imaging Reveal Temporal and Spatial Protein Changes in Human Intestinal Ischemia–Reperfusion

Author

Kip, Anna M., primary, Valverde, Juan Manuel, additional, Altelaar, Maarten, additional, Heeren, Ron M. A., additional, Hundscheid, Inca H. R., additional, Dejong, Cornelis H. C., additional, Olde Damink, Steven W. M., additional, Balluff, Benjamin, additional, and Lenaerts, Kaatje, additional

Published
2021
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29. Evaluating the safety of two human experimental intestinal ischemia reperfusion models: A retrospective observational study

Author

Hundscheid, Inca H. R., primary, Schellekens, Dirk H. S. M., additional, Grootjans, Joep, additional, Den Dulk, Marcel, additional, Van Dam, Ronald M., additional, Beets, Geerard L., additional, Buurman, Wim A., additional, Lenaerts, Kaatje, additional, Derikx, Joep P. M., additional, and Dejong, Cornelis H. C., additional

Published
2021
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36. Thoracic muscle radiation attenuation for the prediction of postoperative pneumonia following partial hepatectomy for colorectal metastasis

Author

van der Kroft, Gregory, van Dijk, David P.J., Rensen, Sander S.S., Van Tiel, Frank H., de Greef, Bianca, West, Malcolm, Ostridge, Kristoffer, Dejong, Cornelis H. C., Neumann, Ulf P., and Olde Damink, Steven W. M.

Abstract

Background Low skeletal muscle radiation attenuation (SM-RA) is indicative of myosteatosis and diminished muscle function. It is predictive of poor outcome following oncological surgery in several cancer types. Postoperative pneumonia is a known risk factor for increased postoperative mortality. We hypothesized that low SM-RA of the respiratory muscles at the 4th thoracic-vertebra (T4) is associated with postoperative pneumonia following liver surgery. Methods Postoperative pneumonia was identified using prospective infection control data. Computed tomography body composition analysis was performed at the L3-and T4 level to determine SM-RA. Body composition variables were corrected for confounders and related to postoperative pneumonia and admission time by multivariable logistic regression. Results Body composition analysis of 180 patients was performed. Twenty-one patients developed postoperative pneumonia (11.6%). Multivariable analysis showed that low T4 SM-RA as well as low L3 SM-RA were significantly associated with postoperative pneumonia (OR 3.65, 95% CI 1.41–9.49, p < 0.01) and (OR 3.22, 95% CI 1.20–8.61, p = 0.02, respectively). Conclusion Low SM-RA at either the L3-or T4-level is associated with a higher risk of postoperative pneumonia following CLRM resection.

Published
2019

44. Resectability and Ablatability Criteria for the Treatment of Liver Only Colorectal Metastases: Multidisciplinary Consensus Document from the COLLISION Trial Group

Author

Nieuwenhuizen, Sanne, primary, Puijk, Robbert S., additional, van den Bemd, Bente, additional, Aldrighetti, Luca, additional, Arntz, Mark, additional, van den Boezem, Peter B., additional, Bruynzeel, Anna M. E., additional, Burgmans, Mark C., additional, de Cobelli, Francesco, additional, Coolsen, Marielle M. E., additional, Dejong, Cornelis H. C., additional, Derks, Sarah, additional, Diederik, Arjen, additional, van Duijvendijk, Peter, additional, Eker, Hasan H., additional, Engelsman, Anton F., additional, Erdmann, Joris I., additional, Fütterer, Jurgen J., additional, Geboers, Bart, additional, Groot, Gerie, additional, Haasbeek, Cornelis J. A., additional, Janssen, Jan-Jaap, additional, de Jong, Koert P., additional, Kater, G. Matthijs, additional, Kazemier, Geert, additional, Kruimer, Johan W. H., additional, Leclercq, Wouter K. G., additional, van der Leij, Christiaan, additional, Manusama, Eric R., additional, Meier, Mark A. J., additional, van der Meijs, Bram B., additional, Melenhorst, Marleen C. A. M., additional, Nielsen, Karin, additional, Nijkamp, Maarten W., additional, Potters, Fons H., additional, Prevoo, Warner, additional, Rietema, Floris J., additional, Ruarus, Alette H., additional, Ruiter, Simeon J. S., additional, Schouten, Evelien A. C., additional, Serafino, Gian Piero, additional, Sietses, Colin, additional, Swijnenburg, Rutger-Jan, additional, Timmer, Florentine E. F., additional, Versteeg, Kathelijn S., additional, Vink, Ted, additional, de Vries, Jan J. J., additional, de Wilt, Johannes H. W., additional, Zonderhuis, Barbara M., additional, Scheffer, Hester J., additional, van den Tol, Petrousjka M. P., additional, and Meijerink, Martijn R., additional

Published
2020
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48. Hepatocellular adenoma in men: A nationwide assessment of pathology and correlation with clinical course.

Author

van Rosmalen, Belle V., Furumaya, Alicia, Klompenhouwer, Anne J., Tushuizen, Maarten E., Braat, Andries E., Reinten, Roy J., Ligthart, Marjolein A. P., Haring, Martijn P. D., de Meijer, Vincent E., van Voorthuizen, Theo, Takkenberg, R. Bart, Dejong, Cornelis H. C., de Man, Robert A., IJzermans, Jan N. M., Doukas, Michail, van Gulik, Thomas M., and Verheij, Joanne

Subjects
CLINICAL pathology, ADENOMA, CURRICULUM, HISTOPATHOLOGY, DIAGNOSIS, HEPATOCELLULAR carcinoma
Abstract

Background & Aims: Hepatocellular adenomas (HCA) rarely occur in males, and if so, are frequently associated with malignant transformation. Guidelines are based on small numbers of patients and advise resection of HCA in male patients, irrespective of size or subtype. This nationwide retrospective cohort study is the largest series of HCA in men correlating (immuno)histopathological and molecular findings with the clinical course. Methods: Dutch male patients with available histological slides with a (differential) diagnosis of HCA between 2000 and 2017 were identified through the Dutch Pathology Registry (PALGA). Histopathology and immunohistochemistry according to international guidelines were revised by two expert hepatopathologists. Next generation sequencing (NGS) was performed to confirm hepatocellular carcinoma (HCC) and/or subtype HCA. Final pathological diagnosis was correlated with recurrence, metastasis and death. Results: A total of 66 patients from 26 centres fulfilling the inclusion criteria with a mean (±SD) age of 45.0 ± 21.6 years were included. The diagnosis was changed after expert revision and NGS in 33 of the 66 patients (50%). After a median follow‐up of 9.6 years, tumour‐related mortality of patients with accessible clinical data was 1/18 (5.6%) in HCA, 5/14 (35.7%) in uncertain HCA/HCC and 4/9 (44.4%) in the HCC groups (P =.031). Four B‐catenin mutated HCA were identified using NGS, which were not yet identified by immunohistochemistry and expert revision. Conclusions: Expert revision with relevant immunohistochemistry may help the challenging but prognostically relevant distinction between HCA and well‐differentiated HCC in male patients. NGS may be more important to subtype HCA than indicated in present guidelines. [ABSTRACT FROM AUTHOR]

Published
2021
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