248 results on '"Deighton K"'
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2. RWD14 Approaches to Selecting ‘Time Zero’ in External Control Arms with Multiple Potential Entry Points: A Simulation Study of Eight Approaches
- Author
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Hatswell, A, primary, Deighton, K, additional, Snider, J, additional, Brookhart, MA, additional, Faghmous, I, additional, and Patel, A, additional
- Published
- 2022
- Full Text
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3. The effect of high altitude on central blood pressure and arterial stiffness
- Author
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Boos, C J, Vincent, E, Mellor, A, Woods, D R, New, C, Cruttenden, R, Barlow, M, Cooke, M, Deighton, K, Scott, P, Clarke, S, and O'Hara, J
- Published
- 2017
- Full Text
- View/download PDF
4. Elective surgery cancellations due to the COVID-19 pandemic: global predictive modelling to inform surgical recovery plans
- Author
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Nepogodiev D., Omar O. M., Glasbey J. C., Li E., Simoes J. F. F., Abbott T. E. F., Ademuyiwa A. O., Biccard B. M., Chaudhry D., Davidson G. H., Di Saverio S., Gallo G., Ghosh D., Harrison E. M., Hutchinson P. J., Kamarajah S. K., Keller D. S., Lawani I., Minaya-Bravo A., Moore R., Morton D. G., Ntirenganya F., Pata F., Pearse R. M., la Medina A. R. -D., Tabiri S., Venn M. L., Omar A. B. O. M., Bhangu A., Siaw-Acheampong K., Adamina M., Agarwal A., Alameer E., Alderson D., Alakaloko F., Alser O., Arnaud A. P., Augestad K. M., Bankhead-Kendall B. K., Barlow E., Benson R. A., Blanco-Colino R., Brar A., Breen K. A., Buarque I. L., Caruana E. J., Chakrabortee S., Cox D., Cunha M. F., Dawson B. E., Desai A., Drake T. D., Edwards J. G., Elhadi M., Evans J. P., Farik S., Fiore M., Fitzgerald J. E., Ford S., Gomes G. M. A., Griffiths E. A., Gujjuri R. R., Halkias C., Heritage E., Isik A., Jenkinson M. D., Jones C. S., Khatri C., Keatley J. M., Kolias A., Lawday S., Lederhuber H., Leventoglu S., LAffler M. W., Martin J., Mashbari H. N., Mazingi D., Mckay S. C., Metallidis S., Mohan H. M., Moszkowicz D., Moug S., Ng-Kamstra J. S., Niquen M., Outani O., Pellino G., Pinkney T. D., Pockney P., Radenkovic D., Roberts K., Roslani A. C., Santos I., Schache A., Schnitzbauer A. A., Stewart G. D., Shaw R., Shu S., Soreide K., Spinelli A., Sundar S., Tiwari A., Townend P., Trout I. M., Tsoulfas G., van Ramshorst G. H., Vidya R., Vimalachandran D., Warren O., Wilkin R. J. W., Wright N., Hoste E., Huyghens L., Jacobs R., Opdenacker G., Poelaert J., Rijckaert D., De Decker K., Foubert L., De Neve N., Biston P., Piagnerelli M., Collin V., den Blauwen N., Clauwaert C., De Crop L., Verbeke A., Derumeaux P., Gardin C., Kindt S., Louage S., Verhamme B., DruwACopyright P., Lahaye I., Rosseel F., Rutsaert R., Vanlinthout L., De Kock M., Forget P., Kahn D., Lois F., Momeni M., Yemnga A. P. B., Jadoul J. -L., Malbrain M., Bosinceanu D., Collard E., Jorens P., Reyntiens D., Smitz C., Vercauteren M., Fagnoul D., Toplice K., OremuA¡ K., BeA¡lic G., Duzel V., Hauptman A., Peremin S., Aribar A., Aupcic M., Brod S., Mirkovic I., Bauer Z. A., Belavic M., BlaA¾anin B., KatuA¡in M. L., Krijan A. B., MiA¡kovic P., Aimic-Korac N., Topic J., Ailic A., Aunic J., Acan I., Adanic M., Ivanov N., Aaric J. P., Tomulic K., Viskovic N., BoA¡njak S., Drenjancevic I. H., Kristek G., Kvolik S., Markic S., Rakipovic A. S., Tot O. K., Fabris L. K., Bacak-Kocman I., Balenovic I., Bandic D., Deutsch P. A. J., Divjak L., Filipovic I. G., GuA¾vinec Z., Krznaric Z., Loncaric Y., MagaA¡ J. V., Mitrovic M., Okic M., Pavlek M., Ramov E., Rezek K., Sekulic A., Tomasevic B., Miric M., TomaA¡evic A., Mahecic T. T., Vrbanovic V., Bobinac M., BoA¾ic A., Debelic D., Frkovic V., Batinica I. M., Baranovic S., Gavranovic A., Kikec M., Maldini B., Maric S., Agnic I., Delic N., Dropulic N., GaA¡pic T. K., Ilic D., Ivancev B., Karanovic N., KuA¡cevic D., Marovic Z., Milic M., NeveA¡canin A., Petkovic T., Smoje M., Brozovic G., Goranovic T., Jelisavac M., Matolic M., Mazul-Sunko B., Oberhofer D., Pavicic A. M., Aakic K., Bozovic M. D., Krecek Z. K., Krobot R., Andabaka T., Bratanic M., Dzepina O., Kraljev M., Aeric J., Aimurina T., Grujic R., Nacevski-Bulaja B., BariA¾on M., Danira V., DraA¾en B., DuA¡anka K., HaluA¾an M. B., JoA¡ko A., Katica R., Labor M., Marinkovic T. G., Mihovilcevic D., Marija B., Srecko M., Drab M., Hudacek K., Krikava I., Stourac P., BrabcovA¡ M., KlozovA¡ R., Vajter J., Vymazal T., Toft P., Blichfeldt L., Hansen B. D., Moller K., Nielsen J. S., Frederiksen J., Andersen J. D., KA¼hne J. P., Leivdal S., Stendell L., Simonsen M., Zoltowski M. K., Ali Z. S., Freundlich M., Pilypaite J., Clausen N. G., Thorup L., Hansen F., Bestle M., Hansen C. S., Afshari A., Bille A. B., Lefort M., Secher E. 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J., Landais A., Mentec H., Bazin M., Futier E., Gonnu S., Petit A., Albaladejo P., Almeras L., Rossi-Blancher A. B. M., Lefrant J. Y., Barthel F., Hallel D., Sbai H., Khalifeh P., Lidzborski L., Jully M., Platon E., Pottecher J., Baumgarten R., Schultz C., ElMiloudi F., Lefebvre J., Waton K., Sprunck A., Steib A., Thibaud A., Thuet V., Kieffer V., Dubois-Vallaud D., Jacob L., Becanne X., Cherfaoui S., Gauzit R., Godier A., Lakhdari M., Samma C. M., Halchini C., Lacroix M., Pinna F., Barbes A., Just B., Mateu P., Benayoun L., Berger P., Granier N., Perrigault P. F., Libert N., De Rudnicki S., Merat S., Bourdet B., FerrACopyright F., Minville V., Piriou V., Rague P., Wallet F., Lebuffe G., Desbordes J., Robin E., Ichai C., Orban J. -C., Gottschalk A., Piontek A., Unterberg M., Hilpert J., Kees M., Triltsch A., Wiegand-LAhnert C., GlAckner C., Hohn A., Rose E., SchrAder S., Wiese O., Awlakpui E., Hoeft A., Scheidemann M., Wittmann M., Ramminger A., Dresden C., de Abreu M. G., Heller A. 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F., Nasopoulou P., Spyropoulou E., Gousia C., Katsanoulas C., Lathyris D., Kyriazopoulos G., Sfyras D., Tsirogianni A., Kostopanagiotou G., Koulenti D., Lignos M., Matsota P., Christopoulos C., Mouratidou A., Vrettou E., Boufidis S., Moka E., Arnaoutoglou E., Koulouras V., Nakos G., Papathanakos G., Anthopoulos G., Choutas G., Karapanos D., Tzani V., Gkiokas G., Nastos K., Nikolakopoulos F., Dragoumanis C., Nikitidis N., Pneumatikos I., Theodorou V., Zacharouli D., Kandi S., Tasopoulos K., Arvaniti K., Matamis D., Mplougoura E., Petropoulou P., Soumpasis I., Amaniti E., Giannakou-Peftoulidou M., Gkeka E., Soultati I., Kokinou M., Papatheodorou L., Stafylaraki M., Giasnetsova T., Gritsi-Gerogianni N., Kydona C., Kiskira O., Koulentis I., Apsokardos A., Dimitropoulos K., Soldatou O., Nathanail C., Papazotos A., Tsakas P., Clouva-Molyvdas P. -M., Kolotoura A., Sartzi M., Papanikolaou S., Polakis P., Karatzas S., Kyparissi A., Papavasilopoulou T., Koukoubani T., Mastora E., Nyktari V., Malliotakis P., Papaioannou A., Bekos V., Maragkou E., Spring A., Ioakeimidou S. 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P., Franco A., Marini F., Di Mauro P., Rapido F., Tommasino C., Bellotti F., Boninsegna D., Castellani G., Sances D., Spano G., Tredici S., Vezzoli D., Fucecchio I., Bacci A., Coppini R., Dell'unto S., Mori E., Stanzani M. R., Tosi M., Collareta M., Forfori F., Franchi M., Mancino G., Battistella M., Baricocchi E., Bona F., Debernardi F., Giacoletto G., Iacobellis A., Massucco P., Moselli N., Muratore A., Palomba G., Sardo E., Suita L., Zocca E., Bucci B., Corte F. D., Piciucco T., Viarengo V., Cantarini E., Giampieri M., Tanfani A., Recchia E., Bignami E., Bruno G., Costagliola R., Gandolfi A., Greco M., Lembo R., Monti G., Nicelli E., Pasculli N., Turi S., Rocca G. D., Baroselli A., Brazzoni M., Buttazzoni M., Buttera S., Centonze C., Serena G., Spagnesi L., Toretti I., Vilardi A., Zearo E., Arpino I., Baraldi S., Guarnerio C., Molene V., Monea M. C., Vaccarisi E., Vicari L., Albante A., Aversano M., Loiacono C., Marandola M., Fusari M., Petrucci N., Galla A., Mascia A., Primieri P., Di Noto A., Gratarola A., Molin A., Pelosi P., Spagnolo L., Spena C., Calligaro P., Marchiotto S., Merlini A., Pedrazzoli E., Perina G., Visentin R., Fumagalli R., Garbagnati A., Manetti B., Snaier C., Somaini M., Farnia A., Nani R., Pierantonio N., Grasso S., Gazzanelli S., Pugliese F., Ruberto F., Bergamini E., Tassinati T., Capuzzo M., Cirillo V., Tufano R., Oggioni R., Parrini V., Brunori E., Capone M., Carbone L., Corradetti F., Elisei D., Fiorentino S., Francesconi M., Gattari D., Gorgoglione M., Iacobone E., Minnucci F., Montironi C., Riccioni G., Tappata G., Zompanti V., Verdenelli P., Cerutti E., Ranieri V. M., Grigorjevs S., Rikmane M., Rozkalne D., Stepanovs J., Suba O., Golubovska I., Kazune S., Miscuk A., Nemme J., Oss P., Sipylaite J., Macas A., Ragaisis V., Kontrimaviciute E., Tomkute G., Boerma E. C., Leeuwarden M. C., Kramer I. F., Poeze M., Maria J., Pelzer G., Nijsten M., Schoorl M., Spanjersberg R., Buhre W., Dieleman S., van Klei W. A., Bouw M., Pickkers P., Schreiner F., Zandvliet R., van den Berg R., De Wit E., Keijzer C., Hollmann M. W., Preckel B., van Acker G. J. D., Dennesen P. J. W., Kuijpers-Visser A. G., Inan T., Gemert A. W. M. M. K. -V., Ponssen H. H., Brouwer T., Koopmans M., van Bommel J., van Duijn D., van der Hoven B., Ormskerk P., Beck O., Schiere S., Reidinga A. C., Venema A., Jammer I., Dokka V., Monsen S. A., Ytrebo L. M., Noursadeghi M., Shahzad A., Boksasp O. D., Roiss C., Strietzel H. F., Berntsen A. G. S., Haugland H., Vingsnes S. O., Axelsson P., Risom Olsen T. C., Katre S., Aakeroey K., Tamowicz B., Bozilow D., Goch R., Grabowski P., Kupisiak J., Mallek M., Szyca R., Kostyrka W., Choma R., Jankowski G., Koscielniak W., Pietraszek P., Szarowar B., FranA§a C., Lacerda A. P., Ormonde L., Rosa R., Pereira I., Vitor P., Bento H. C., Carvalho M. R. L. 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A., Calin M., Ionescu D., Margarit S., Vasian H., Albu C., Balasa C., Cadrigati A., Dragulescu D., Gavra L., Hentia C., Macarie C., Manescu M., Nediglea I., Ocica D., Ovidiu B., Papurica M., Plavat C., Popa C., Ramneantu M., Sandesc D., Sandici Z., Sarandan M., Belciu I., Tincu E., Aignatoaie M., Huzuneanu M., Cocu S., Hagau N., Ciubotaru R., Copotoiu S. -M., Copotoiu R., Ioana G., Kovacs J., Leonard A., Szederjesi I., Genoveva V., Mosnegutu S., Djordjevic D., Djordjevic B., Grujic K., Jovanovic D., Obradovic J., Zeba S., Jevdjic J., Miletic M., Zunic F., Bulasevic A., Brko R., Gazibegovic N., Kendrisic M., Vojinovic R., CapkovA¡ J., Firment J., Grochova M., Trenkler S., Griger M., Zahorec R., Bakosova E., Kvasnica M., Saniova B., Sulaj M., Zacharovska A., Simkova A., CAkovA¡ A., Gebhardtova A., HanuljakovA¡ S., Koutun J., MartonovA¡ A., AilincA¡rovA¡ V., Galkova K., Krbila S., Sobona V., Ocenasova M., Novak-Jankovic V., Stecher A., Stivan F., Grynyuk A., Damjanovska M., Kostadinov I., Knezevic M., Malivojevic M., Borovsak Z., Kamenik M., MekiA¡ D., KapA¡ S. O., Aleksic D., Gerjevic B., Kalan K., Ursic T., Artigas A., Garcia A., Lisi A., Perez I., Perez G., Poch N., Vaquer S., Balciscueta G., Barrasa H., Cabanes S., Maynar J., Poveda Y., Rodero A. Q., Vallejo A., Duque P., Garcia-Bunger B., Elvira M. A., Lajara A. M., Palencia M., Ramos R., Fernandez A. S., LeAn J. P. T., LApez J. I., Murillo F. J. Y., Ramirez E. T., Rico P. U., Patricia M., VizcaAno M., Alvarez M. J. B., Real K. P., Serra A. M., Aracil N., Bodega B. M., GarcAa R. F., GarcAa M. A., de la Quintana Gordon B., JodrA¡ A. G., LApez A. D. S., Ros J. J. L., Soto R. A., SepAºlveda I., DAez E. P., FernA¡ndez L. F., Gulina C. S., Arviza L. P., Fernandez L. M., GAmez A. R., MartAnez C. A., RodrAguez A. B. R., Soto C. L., Aldecoa C., Garcia C., Lorenzo M., Pinilla E., Rico J., Ruperez I., Alonso E., Leira F., Maseda D. P. E., Royo C., Villagran J., Candi G. M., Esteva G. E., Folgado R. M., Fornaguera N. J., Montse P. C., Prat A. S., Sintes D., Arteta D. A., Delgado H. G., LApez-Cuervo J. F., LApez M. C., RamArez A., SaldaA+/-a F. J., Aliste P., Anchuelo A. H., Campos A. G., CatalA¡n M., GAmez M. G., Gonzalaez O. G., LApez E. L., Navacerrada I. R., de Quevedo S. A., Serrano M. G., Silvestre F. P. -C., Torrente F. M., Arocas B., Martinez E. P., Soro M., Maroto F., Algarra R. R., Aleixandre I. S., Argente G. R., LleA A. B., Rubio A. V., SA¡nchez J. L. V., ValcA¡rcel I. E., Balust C., Balust J., Borrat X., Carretero M. J., Gracia I., Matute P., Mercadal J., Pujol R., Tena B., Ubre M., Albalad D. D., Alcaide C. M., Caballero J., Cervantes A. C., de Nadal Clanchet M., Estruch N. M., Ferrer M. B., Fornells A. L., Galera E. T., Martinez I. G., MuA+/-oz S. M., Pelavski A., Perez P. T., Posada M. A. G., de Prat I. C., Rello J., Serrano L. G., Sieiro J. M. N., Silva L., Sole M. J. C., SuA+/-ACopyright A. B., Villach I. R., Herreras J. I. G., Poves R., Rafael B. M., Almeida I. M., Collates A. F., BartolomACopyright M. J., Cimadevilla B., GonzA¡lez A. M. 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D., Ekwen G., Kaggya M., Constance N., Samuel N., Akanyun S., Freeman T., Royas L., Tchoupa M., Simo W. A. G., Ngouane D., Tanjong B. N., Bouya A. P., Carlos F., Gallou P. D., Prosper A., Athombo J. S., Sanduku D. K., Mampangula Y., Nziene V. N., Odia P. K., Mbombo W. D., Wms M., Mukuna P. M., Boloko P. M., Mvwama N. M., Jjn I., Manzombi J. K., Mvwala K. R., Ilunga J. P. M., Mawisa T., Kilembe A. M., Bikuelo C. J., Mwepu I. M., Mwaluka C. N., Sarah H. N., Kukembila A. M., Diyoyo M. P., Ngalala A. M., Kabango R., Kongolo M., Mbayabu M., Namegabe E. S., Bula Bula I. M., Likongo T. B., Pengemale G. N., Bingidimi S. S., Imposo D. H., Matondo P. M., Lelo S. N., Kamanda R. J., Kady N., Ntueba B., Christian M., Badianga E. K., Clc L., Mubeya F. K., Bahta M. T., Kassa S. K., Assefa S. B., Girmaye G. T., Samateh A. L., Janneh L., Sanyang L. N., Nyassi M. T., Grey-Johnson S. V., Villarreal R., AntAnez O., Jallow C. S., Roberts C. A., Clegg-Lamptey J. N., Kutor Y. Y., Adu-Aryee N. 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R., Fanjandrainy R. F., Coulibaly Y., Zie S. Z., Gangaly D., Mahamane D. D., Toure Mamadou K., Simaga Abdoul K., Ibrahim T., Abdoulaye T., Alioune B. S., Souleymane T., Oumar O., Sogoba G., Amadou M., Moussa K., Veerasamy B., Heerah H. M. S. N., Limbajee M. L., Alleesaib S. B. M., Ramchurn T. P. R., Mandarry M. T. M., Joomye S., Thakoor B., Aungraheeta M., Sookun S. S., Lumbala K. F., Ikandi K., Kabongo L. T., Garcia M., Izquirdo P., Castro A. C., Ilunga I. B. B., Imbangu N. A. V., Nakandungile F., Mmasi J. E., Tobiko O., Polishchuk O., Kashuupulwa P. N. K., Kalume S., Sihope S. E., Arrey O., Kakololo S. I., Taiwo N. A., Kairuki P. C. K., Gazmuri O. G. G., Imene A. M., Umenushkin U. A., Kibandwa A., Cisekedi J. C., Nakangombe P., Musiba V. E. M., Gama G. G. N., Mwanga H. A. M., Mgonja L., Rink B., Amisi B. T., Bangure L., Rois W., Rois I., Sabwa H. K., Barongo M. L., Tshisekedi S. M., Mbuyi T., Lyimo T. S. K., Munyika A. A., Kornilov A. A., Rwehumbiza S. S. R., Kumar M., Makopa E. 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P., Moses V. L., Mungherera A. R. 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J., Mashbari H.N., Mazingi D., Mckay S.C., Metallidis S., Mohan H.M., Moszkowicz D., Moug S., Ng-Kamstra J.S., Niquen M., Outani O., Pellino G., Pinkney T.D., Pockney P., Radenkovic D., Roberts K., Roslani A.C., Santos I., Schache A., Schnitzbauer A.A., Stewart G.D., Shaw R., Shu S., Soreide K., Spinelli A., Sundar S., Tiwari A., Townend P., Trout I.M., Tsoulfas G., van Ramshorst G.H., Vidya R., Vimalachandran D., Warren O., Wilkin R.J.W., Wright N., Hoste E., Huyghens L., Jacobs R., Opdenacker G., Poelaert J., Rijckaert D., De Decker K., Foubert L., De Neve N., Biston P., Piagnerelli M., Collin V., den Blauwen N., Clauwaert C., De Crop L., Verbeke A., Derumeaux P., Gardin C., Kindt S., Louage S., Verhamme B., Druwe P., Lahaye I., Rosseel F., Rutsaert R., Vanlinthout L., De Kock M., Forget P., Georges P., Grosu I., Kahn D., Lois F., Momeni M., Yemnga A.P.B., Jadoul J.-L., Malbrain M., Bosinceanu D., Collard E., Jorens P., Reyntiens D., Smitz C., Vercauteren M., Fagnoul D., Toplice K., Oremus K., Beslic G., Duzel V., Hauptman A., Peremin S., Sribar A., Zupcic M., Brod S., Mirkovic I., Bauer Z.S., Belavic M., Blazanin B., Katusin M.L., Krijan A.B., Miskovic P., Simic-Korac N., Topic J., Zilic A., Zunic J., Acan I., Adanic M., Ivanov N., Saric J.P., Tomulic K., Viskovic N., Bosnjak S., Drenjancevic I.H., Kristek G., Kvolik S., Markic S., Rakipovic A.S., Tot O.K., Fabris L.K., Bacak-Kocman I., Balenovic I., Bandic D., Deutsch P.A.J., Divjak L., Filipovic I.G., Guzvinec Z., Krznaric Z., Loncaric Y., Magas J.V., Mitrovic M., Okic M., Pavlek M., Ramov E., Rezek K., Sekulic A., Tomasevic B., Miric M., Tomasevic A., Mahecic T.T., Vrbanovic V., Bobinac M., Bozic A., Debelic D., Frkovic V., Batinica I.M., Baranovic S., Gavranovic Z., Kikec M., Maldini B., Maric S., Agnic I., Delic N., Dropulic N., Gaspic T.K., Ilic D., Ivancev B., Karanovic N., Kuscevic D., Marovic Z., Milic M., Nevescanin A., Petkovic T., Smoje M., Brozovic G., Goranovic T., Jelisavac M., Matolic M., Mazul-Sunko B., Oberhofer D., Pavicic A.M., Sakic K., Bozovic M.D., Krecek Z.K., Krobot R., Andabaka T., Bratanic M., Dzepina O., Kraljev M., Seric J., Simurina T., Grujic R., Nacevski-Bulaja B., Barizon M., Danira V., Drazen B., Dusanka K., Haluzan M.B., Josko Z., Katica R., Labor M., Marinkovic T.G., Mihovilcevic D., Marija B., Srecko M., Drab M., Hudacek K., Krikava I., Stourac P., Brabcova M., Klozova R., Vajter J., Vymazal T., Toft P., Blichfeldt L., Hansen B.D., Moller K., Nielsen J.S., Frederiksen J., Andersen J.D., Kuhne J.P., Leivdal S., Stendell L., Simonsen M., Zoltowski M.K., Ali Z.S., Freundlich M., Pilypaite J., Clausen N.G., Thorup L., Hansen F., Bestle M., Hansen C.S., Afshari A., Bille A.B., Lefort M., Secher E.L., Liboriussen L., Herodes V., Harma E., Marvet K., Pool K., Kallas P., Magi T.-K., Sutt J., Vijar K., Visk E., Vinnal M., Ellermaa J., Liibusk L., Hovilehto S., Kirsi A., Mustola S., Tiainen P., Toivonen J., Dabnell S., Kaminski T., Sysimetsa A., Kaukonen M., Silvasti P., Vainio K., Lund V., Sjovall S., Saarinen K., Viitanen M., Ahonen T., Alaspaa A., Zittling R., Saarinen A., Moisander A., Wagner B., Laru-Sompa R., Elomaa E., Lavonen L., Nevantaus J., Geier K., Kavasmaa T., Koorits U., Kubjas M., Lauritsalo S., Ottelin L., Palve M., Pynnonen J., Raabis I., Saarelainen M., Heikkila T., Kontula T., Lehtimaki M., Liimatainen J., Moilanen-Oikarinen M., Pakarinen M., Palanne R., Seppanen H., Pulkkinen A., Vaaraniemi H., Kajaani, Paananen S., Koskenkari J., Salkio S., Vakkala M., Koskue T., Loisa P., Laitio R., Hautamaki R., Koivisto S.-P., Leon A., Bonnet F., Marret E., Spielvogel C., Papageorgiou C., Szymkiewicz O., Tounou-Akue F., Aubrun F., Bonnet A., Gazon M., Guiraud M., Laurent V., Tachon G., Demars N., Dumenil A.-S., Mercier F.J., Landais A., Mentec H., Bazin M., Futier E., Gonnu S., Petit A., Albaladejo P., Almeras L., Rossi-Blancher A.B.M., Lefrant J.Y., Barthel F., Hallel D., Sbai H., Khalifeh P., Lidzborski L., Jully M., Platon E., Pottecher J., Baumgarten R., Schultz C., ElMiloudi F., Lefebvre J., Waton K., Sprunck A., Steib A., Thibaud A., Thuet V., Kieffer V., Dubois-Vallaud D., Jacob L., Becanne X., Cherfaoui S., Gauzit R., Godier A., Lakhdari M., Samma C.M., Halchini C., Lacroix M., Pinna F., Barbes A., Just B., Mateu P., Benayoun L., Berger P., Granier N., Perrigault P.F., Libert N., De Rudnicki S., Merat S., Bourdet B., Ferre F., Minville V., Piriou V., Rague P., Wallet F., Lebuffe G., Desbordes J., Robin E., Ichai C., Orban J.-C., Gottschalk A., Piontek A., Unterberg M., Hilpert J., Kees M., Triltsch A., Wiegand-Lohnert C., Glockner C., Hohn A., Rose E., Schroder S., Wiese O., Awlakpui E., Hoeft A., Scheidemann M., Wittmann M., Ramminger A., Dresden C., de Abreu M.G., Heller A.R., Marx C., Neidel J., Goldmann A., von Heymann C., Laetsch B., Maahs E., Scholz L., Frenzel D., Massarat K., Lenhart F.-P., Reichle F., Rudlof K., Borchers F., Buettner C., Schmutzler M., Lucht A., Wagner J., Wuppertal H.K., Pilge 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Stathopoulos A., Voulas A., Kanna E., Koutsikou A., Moustaka A., Chovas A., Komnos A., Zafiridis T., Franses J., Lavrentieva A., Koraki E., Katsenos C., Kasianidou M.F., Nasopoulou P., Spyropoulou E., Gousia C., Katsanoulas C., Lathyris D., Kyriazopoulos G., Sfyras D., Tsirogianni A., Kostopanagiotou G., Koulenti D., Lignos M., Matsota P., Christopoulos C., Mouratidou A., Vrettou E., Boufidis S., Moka E., Arnaoutoglou E., Koulouras V., Nakos G., Papathanakos G., Anthopoulos G., Choutas G., Karapanos D., Tzani V., Gkiokas G., Nastos K., Nikolakopoulos F., Dragoumanis C., Nikitidis N., Pneumatikos I., Theodorou V., Zacharouli D., Kandi S., Tasopoulos K., Arvaniti K., Matamis D., Mplougoura E., Petropoulou P., Soumpasis I., Amaniti E., Giannakou-Peftoulidou M., Gkeka E., Soultati I., Kokinou M., Papatheodorou L., Stafylaraki M., Giasnetsova T., Gritsi-Gerogianni N., Kydona C., Kiskira O., Koulentis I., Apsokardos A., Dimitropoulos K., Soldatou O., Nathanail C., Papazotos A., Tsakas P., 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Saad H., Shanmugam M., Varley S., Wylie K., Cooper L., Makowski A., Misztal B., Moldovan E., Pegg C., Donovan A., Foot J., Large S., Netke B., Armstrong R., Calderwood C., Kwok A., Mohr O., Oyeniyi P., Patnaik L., Post B., Ali S., Arshad H., Baker G., Brenner L., Brincat M., Brunswicker A., Cox H., Cozar O.I., Durst A., Fengas L., Flatt J., Glister G., Narwani V., Photi E., Rankin A., Beaton C., Horn R., Hunt J., Rousseau G., Stancombe L., Absar M., Allsop J., Drinkwater Z., Hodgkiss T., Smith K., Alexander-Sefre F., Campey L., Dudgeon L., Hall K., Hitchcock R., James L., Winstone U., Ahmad N., Bauchmuller K., Harrison J., Jeffery H., Miller D., Pinder A., Pothuneedi S., Rosser J., Sanghera S., Swift D., Bester D., Cavanagh S., Cripps H., Daniel H., Lynch J., Pyke S., Scholefield J., Whitworth H., Ramalingam G., Akerman N., Antill P., Bourner L., Buckley S., Castle G., Charles R., Eggleston C., Foster R., Gill S., Lindley K., Lklouk M., Lowery T., Martin O., Milne D., O'Connor P., 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Campbell K., Lu F., Scannell J., Sobol J., Balajonda N., Clemmons K., Conde C., Funk B., Hopkins T., Olaleye O., Omer O., Pender M., Porto A., Waweru P., Yeh E., Bodansky D., Evans A., Kleopoulos S., Maril R., Mathney E., Sanchez A., Tinuoye E., Bateman B., Eng K., Jiang N., Ladha K., Needleman J., Chen L.-L., Lane R., Robinowitz D., Ghushe N., Irshad M., Takemoto S., Wallace A., Mazzeffi M., Rock P., Wallace K., Zhu X., Chua P., Mattera M., Sharar R., Thilen S., Treggiari M., Morgan A., Sofjan I., Subramaniam K., Avidan M., Maybrier H., Muench M., Wildes T., Elkhogia A.M., Omigbodun A.O., Antwi-Kusi A., Samateh A.L.S., Ndonga A., Basenero A., Mbwele B., Gordon C.S., Youssouf C., Ashebir D.Z., Munlemvo D.M., Zoumenou E., Madzimbamuto F., Ndayisaba G., Sama H.D., Ndasi H., Kluyts H.-L., Tumukunde J., Fawzy M., Mehyaoui R.M., Amanor-Boadu S.D., Rakotoarison S., Esterhuizen T.M., Patel U., Gobin V., Le Manach Y., Ngumi Z., Mehyaoui R., Kanoun H., Chelbi L., Alghazali A., Metali A., 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Ngalala A.M., Kabango R., Kongolo M., Mbayabu M., Namegabe E.S., Bula Bula I.M., Likongo T.B., Pengemale G.N., Bingidimi S.S., Imposo D.H., Matondo P.M., Lelo S.N., Kamanda R.J., Kady N., Ntueba B., Christian M., Badianga E.K., Clc L., Mubeya F.K., Bahta M.T., Kassa S.K., Assefa S.B., Girmaye G.T., Samateh A.L., Janneh L., Sanyang L.N., Nyassi M.T., Grey-Johnson S.V., Villarreal R., Antunez O., Jallow C.S., Roberts C.A., Clegg-Lamptey J.N., Kutor Y.Y., Adu-Aryee N.A., Domoyyeri D.P., Atito-Narh E., Anabah T.W.A., Ndonga A.K.N., Ngumi Z.W.W., Bitta C., Nyawanda H.O., Oduor O.E.O., Okelo O.S., Ogendo S.W.O., Ngari N.B.M., Nyokabi N.N., Chokwe T.M., Gacii V.M., Githae B., Gatheru A.P., Maranga O., Muriithi J.M., Mwangi C.M., Mwiti T.M., Nabulindo S.M., Ndung'u C., Mugambi J., Mtongwe V.M., Kiprop B., Mbadi R., Wambugu P.K., Hersi S., Mutahi S., Aluvale J.S., Gitau S., Kariuki K., Ngatia E., Sitima S., Obadiah S., Mwenda V., Iraya A.M., Waweru E.N., Muturi A., Miima S., Ojujo M., Mossy P., 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Rakotoarison S.R., Albert F., Hery A.H., Mamy R.M., Andriamampionona A.G.B., Judicael M., Ramilson H.E., Eloi H., Athanse V., Zo A., Andrianina L., Judicael R.M., Rakotoarisoa A.H.N., Rakotoarijaona A.H.R., Ramananasoa M.L.R., Angelin R., Hanta R., Raherison R.A.R., Rija F.R., Fanjandrainy R.F., Coulibaly Y., Zie S.Z., Gangaly D., Mahamane D.D., Toure Mamadou K., Simaga Abdoul K., Ibrahim T., Abdoulaye T., Alioune B.S., Souleymane T., Oumar O., Sogoba G., Amadou M., Moussa K., Veerasamy B., Heerah H.M.S.N., Limbajee M.L., Alleesaib S.B.M., Ramchurn T.P.R., Mandarry M.T.M., Joomye S., Thakoor B., Aungraheeta M., Sookun S.S., Lumbala K.F., Ikandi K., Kabongo L.T., Garcia M., Izquirdo P., Castro A.C., Ilunga I.B.B., Imbangu N.A.V., Nakandungile F., Mmasi J.E., Tobiko O., Polishchuk O., Kashuupulwa P.N.K., Kalume S., Sihope S.E., Arrey O., Kakololo S.I., Taiwo N.A., Kairuki P.C.K., Gazmuri O.G.G., Imene A.M., Umenushkin U.A., Kibandwa A., Cisekedi J.C., Nakangombe P., Musiba V.E.M., Gama 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N.T., Freeman Y.B.M., Ehouni A., Jithoo S., Naidoo L., Peter A.M., Belhaj S., Tun M., Kapp P., Bwambale Y.B., Holder H., Kasongo K.J.P., Makhanya V., Morapedi M., Mahomedy N.A., Pillay V., Reddy S.R., Mgoqo N., Mrara B., Nibe Z., Ninise E., Pahlana S.M., Usenbo A.O., Malongwe S.M., Nepogodiev, D., Omar, O. 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W., Wright, N., Hoste, E., Huyghens, L., Jacobs, R., Opdenacker, G., Poelaert, J., Rijckaert, D., De Decker, K., Foubert, L., De Neve, N., Biston, P., Piagnerelli, M., Collin, V., den Blauwen, N., Clauwaert, C., De Crop, L., Verbeke, A., Derumeaux, P., Gardin, C., Kindt, S., Louage, S., Verhamme, B., Druwacopyright, P., Lahaye, I., Rosseel, F., Rutsaert, R., Vanlinthout, L., De Kock, M., Forget, P., Kahn, D., Lois, F., Momeni, M., Yemnga, A. P. B., Jadoul, J. -L., Malbrain, M., Bosinceanu, D., Collard, E., Jorens, P., Reyntiens, D., Smitz, C., Vercauteren, M., Fagnoul, D., Toplice, K., Oremua¡, K., Bea¡lic, G., Duzel, V., Hauptman, A., Peremin, S., Aribar, A., Aupcic, M., Brod, S., Mirkovic, I., Bauer, Z. A., Belavic, M., Blaa¾anin, B., Katua¡in, M. L., Krijan, A. B., Mia¡kovic, P., Aimic-Korac, N., Topic, J., Ailic, A., Aunic, J., Acan, I., Adanic, M., Ivanov, N., Aaric, J. P., Tomulic, K., Viskovic, N., Boa¡njak, S., Drenjancevic, I. H., Kristek, G., Kvolik, S., Markic, S., Rakipovic, A. S., Tot, O. K., Fabris, L. K., Bacak-Kocman, I., Balenovic, I., Bandic, D., Deutsch, P. A. J., Divjak, L., Filipovic, I. G., Gua¾vinec, Z., Krznaric, Z., Loncaric, Y., Magaa¡, J. V., Mitrovic, M., Okic, M., Pavlek, M., Ramov, E., Rezek, K., Sekulic, A., Tomasevic, B., Miric, M., Tomaa¡evic, A., Mahecic, T. T., Vrbanovic, V., Bobinac, M., Boa¾ic, A., Debelic, D., Frkovic, V., Batinica, I. M., Baranovic, S., Gavranovic, A., Kikec, M., Maldini, B., Maric, S., Agnic, I., Delic, N., Dropulic, N., Gaa¡pic, T. K., Ilic, D., Ivancev, B., Karanovic, N., Kua¡cevic, D., Marovic, Z., Milic, M., Nevea¡canin, A., Petkovic, T., Smoje, M., Brozovic, G., Goranovic, T., Jelisavac, M., Matolic, M., Mazul-Sunko, B., Oberhofer, D., Pavicic, A. M., Aakic, K., Bozovic, M. D., Krecek, Z. 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K., Ramnarain, H., Rocher, A. G. L., Singh, S., Stoltenkamp, H. L., Alberts, A. N. J. D., Luthuli, L., Lumbamba, A. J. M., Anderson, P. G. R., du Plessis, W. M., Ellis, S., Ford, L. M., Rousseau, F. J., Rousseau, N., Steyn, G., Steyn, H. C., Weideman, M., Church, B., Holford, E. B., Szpytko, A. J., Brouckaert, N. T., Freeman, Y. B. M., Ehouni, A., Jithoo, S., Naidoo, L., Peter, A. M., Belhaj, S., Tun, M., Kapp, P., Bwambale, Y. B., Holder, H., Kasongo, K. J. P., Makhanya, V., Morapedi, M., Mahomedy, N. A., Pillay, V., Reddy, S. R., Mgoqo, N., Mrara, B., Nibe, Z., Ninise, E., Pahlana, S. M., Usenbo, A. O., Malongwe, S. M., Giles, D. G., Porrill, O. S., Reed, A. R., Visser, J., Davies, G. L., Koller, V. L., Moodie, Q. K., Spicer, J. M., Van Dyk, J. G., Diedericks, B. J. S., Esterhuizen, J. L., Mavhungu, R., Mhlari, T. M., Akhter, M., Baloyi, A. M., Bamuza, K. A., Bamuza, M. I., Bashiya, L., Blignaut, F., Machowski, A. Z., Madzivhe, L. J., Mafafo, S. C., Mashile, M. V., Masia, O. R., Masipa, J. N., Matenchi, M. W., Mathe, R. C., Mogale, J. O., Mohlala, M. P., Mongwe, K. N., Morulana, T. G., Motloutsi, S. P., Mphephu, P. E., Muroonga, M. P., Mzezewa, S. Z., Neil, M. C., Neluheni, E. V., Nesengani, D. S., Nesengani, N. T., Netshimboni, L. E., Notoane, I., Omoding, S., Orjiako, O., Perez, N., Pheeha, R. M., Pilusa, K. A., Pochana, M. P., Pupyshev, M., Rambau, M., Ramuntshi, R., Roura, H., Ryabchiy, B. B., Ryndine, V., Sebei, M. P., Moses, V. L., Mungherera, A. R. W., and Pansegrouw, J.
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Adult ,Global Health ,SARS‐CoV‐2 ,Health Services Accessibility ,NO ,cancellation ,Models ,COVID‐19 ,Humans ,Pandemics ,Bayes Theorem ,COVID-19 ,Elective Surgical Procedures ,Health Care Rationing ,Health Policy ,Infection Control ,Models, Statistical ,health care economics and organizations ,Elective Surgical Procedure ,Original Articles ,Statistical ,elective surgery ,Original Article ,human activities ,Human - Abstract
The COVID-19 pandemic has disrupted routine hospital services globally. This study estimated the total number of adult elective operations that would be cancelled worldwide during the 12 weeks of peak disruption due to COVID-19.A global expert response study was conducted to elicit projections for the proportion of elective surgery that would be cancelled or postponed during the 12 weeks of peak disruption. A Bayesian β-regression model was used to estimate 12-week cancellation rates for 190 countries. Elective surgical case-mix data, stratified by specialty and indication (surgery for cancer versus benign disease), were determined. This case mix was applied to country-level surgical volumes. The 12-week cancellation rates were then applied to these figures to calculate the total number of cancelled operations.The best estimate was that 28 404 603 operations would be cancelled or postponed during the peak 12 weeks of disruption due to COVID-19 (2 367 050 operations per week). Most would be operations for benign disease (90·2 per cent, 25 638 922 of 28 404 603). The overall 12-week cancellation rate would be 72·3 per cent. Globally, 81·7 per cent of operations for benign conditions (25 638 922 of 31 378 062), 37·7 per cent of cancer operations (2 324 070 of 6 162 311) and 25·4 per cent of elective caesarean sections (441 611 of 1 735 483) would be cancelled or postponed. If countries increased their normal surgical volume by 20 per cent after the pandemic, it would take a median of 45 weeks to clear the backlog of operations resulting from COVID-19 disruption.A very large number of operations will be cancelled or postponed owing to disruption caused by COVID-19. Governments should mitigate against this major burden on patients by developing recovery plans and implementing strategies to restore surgical activity safely.La pandemia de COVID-19 ha interrumpido los servicios hospitalarios habituales a nivel mundial. En este estudio se calculó el número total de operaciones electivas para adultos que se cancelarían en todo el mundo durante las 12 semanas de interrupción máxima debido a COVID’19. MÉTODOS: Se realizó un estudio global de respuestas de expertos para obtener proyecciones sobre la proporción de cirugía electiva que se cancelaría o pospondría durante las 12 semanas del pico máximo de disrupción. Se usó un modelo bayesiano de regresión beta para estimar las tasas de cancelación durante 12 semanas en 190 países. Se determinaron los datos de la casuística de casos quirúrgicos electivos, estratificados por especialidad e indicación (cáncer versus cirugía benigna). Esta casuística de casos se aplicó a volúmenes quirúrgicos a nivel de país. Las tasas de cancelación de las 12 semanas se aplicaron a estas cifras para calcular el total de operaciones suspendidas.La mejor estimación fue que 28.404.603 operaciones hubieran sido canceladas o pospuestas durante las 12 semanas del pico de disrupción por COVID-19 (2.367.050 operaciones por semana). La mayoría hubieran sido operaciones por enfermedad benigna (90,2%, 25.638.922/28. 404. 603). La tasa de cancelación general en 12 semanas sería del 72,3%. A nivel mundial, el 81,7% (25.638.921/31.378.062) de la cirugía benigna, el 37,7% (2. 324.069/6.162.311) de la cirugía por cáncer y el 25,4% (441.611/1.735.483) de las cesáreas electivas hubieran sido canceladas o pospuestas. Si los países aumentan su volumen quirúrgico normal en un 20% después de la pandemia, se tardaría una mediana de 45 semanas para eliminar la acumulación de operaciones resultantes de la disrupción por COVID’19. CONCLUSIÓN: Se cancelará o pospondrá un número muy grande de operaciones debido a la disrupción causada por COVID-19. Los gobiernos deberían mitigar esta importante carga para los pacientes mediante el desarrollo de planes de recuperación e implementando estrategias para reiniciar de manera segura la actividad quirúrgica.
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- 2020
5. Effects of a mediterranean diet on the gut microbiota and microbial metabolites: A systematic review of randomized controlled trials and observational studies
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Kimble, R, Gouinguenet, P, Ashor, A, Stewart, C, Deighton, K, Matu, J, Griffiths, A, Malcomson, FC, Joel, A, Houghton, D, Stevenson, E, Minihane, AM, Siervo, M, Shannon, OM, Mathers, JC, Kimble, R, Gouinguenet, P, Ashor, A, Stewart, C, Deighton, K, Matu, J, Griffiths, A, Malcomson, FC, Joel, A, Houghton, D, Stevenson, E, Minihane, AM, Siervo, M, Shannon, OM, and Mathers, JC
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- 2022
6. The effect of rugby training on indirect markers of gut permeability and gut damage in academy level rugby players.
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Chantler, S, Griffiths, A, Phibbs, P, Roe, G, Ramírez-López, C, Davison, G, Jones, B, Deighton, K, Chantler, S, Griffiths, A, Phibbs, P, Roe, G, Ramírez-López, C, Davison, G, Jones, B, and Deighton, K
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PURPOSE: To assess indirect markers of intestinal endothelial cell damage and permeability in academy rugby players in response to rugby training at the beginning and end of preseason. METHODS: Blood and urinary measures (intestinal fatty acid binding protein and lactulose:rhamnose) as measures of gastrointestinal cell damage and permeability were taken at rest and after a standardised collision-based rugby training session in 19 elite male academy rugby players (age: 20 ± 1 years, backs: 89.3 ± 8.4 kg; forwards: 111.8 ± 7.6 kg) at the start of preseason. A subsample (n = 5) repeated the protocol after six weeks of preseason training. Gastrointestinal symptoms (GIS; range of thirteen standard symptoms), aerobic capacity (30-15 intermittent fitness test), and strength (1 repetition maximum) were also measured. RESULTS: Following the rugby training session at the start of preseason, there was an increase (median; interquartile range) in intestinal fatty acid binding protein (2140; 1260-2730 to 3245; 1985-5143 pg/ml, p = 0.003) and lactulose:rhamnose (0.31; 0.26-0.34 to 0.97; 0.82-1.07, p < 0.001). After six weeks of preseason training players physical qualities improved, and the same trends in blood and urinary measures were observed within the subsample. Overall, the frequency and severity of GIS were low and not correlated to markers of endothelial damage. CONCLUSIONS: Rugby training resulted in increased intestinal endothelial cell damage and permeability compared to rest. A similar magnitude of effect was observed after six weeks of pre-season training. This was not related to the experience of GIS.
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- 2022
7. Orion Exploration Flight Test Post-Flight Inspection and Analysis
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Miller, J. E, Berger, E. L, Bohl, W. E, Christiansen, E. L, Davis, B. A, Deighton, K. D, Enriquez, P. A, Garcia, M. A, Hyde, J. L, and Oliveras, O. M
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Spacecraft Design, Testing And Performance - Abstract
The multipurpose crew vehicle, Orion, is being designed and built for NASA to handle the rigors of crew launch, sustainment and return from scientific missions beyond Earth orbit. In this role, the Orion vehicle is meant to operate in the space environments like the naturally occurring meteoroid and the artificial orbital debris environments (MMOD) with successful atmospheric reentry at the conclusion of the flight. As a result, Orion's reentry module uses durable porous, ceramic tiles on almost thirty square meters of exposed surfaces to accomplish both of these functions. These durable, non-ablative surfaces maintain their surface profile through atmospheric reentry; thus, they preserve any surface imperfections that occur prior to atmospheric reentry. Furthermore, Orion's launch abort system includes a shroud that protects the thermal protection system while awaiting launch and during ascent. The combination of these design features and a careful pre-flight inspection to identify any manufacturing imperfections results in a high confidence that damage to the thermal protection system identified post-flight is due to the in-flight solid particle environments. These favorable design features of Orion along with the unique flight profile of the first exploration flight test of Orion (EFT-1) have yielded solid particle environment measurements that have never been obtained before this flight.
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- 2017
8. Effects of a Mediterranean diet on the gut microbiota and microbial metabolites: A systematic review of randomised controlled trials and observational studies
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Kimble R, Gouinguenet P, Ashor A, Stewart C, Deighton K, Matu J, Griffiths A, Malcomson FC, Joel A, Houghton D, Stevenson E, Minihane AE, Siervo M, Shannon OM, Mathers JC
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- 2022
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9. POSC4 Modeling Health-Related Outcomes With Avelumab as a First-Line Maintenance Treatment Following Chemotherapy vs. Best Supportive Care (BSC) for Patients With Locally Advanced or Metastatic Urothelial Cancer in the UK
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Critchlow, S, primary, Xiao, Y, additional, Crabb, S, additional, Eccleston, A, additional, Christoforou, K, additional, Amin, A, additional, Bullement, A, additional, Deighton, K, additional, Chang, J, additional, Kearney, M, additional, Kapetanakis, V, additional, and Benedict, Á, additional
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- 2022
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10. HVI Ballistic Limit Characterization of Fused Silica Thermal Panes
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Miller, J. E, Bohl, W. D, Christiansen, E. L, Davis, B. A, and Deighton, K. D
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Space Transportation And Safety - Abstract
Fused silica window systems are used heavily on crewed reentry vehicles, and they are currently being used on the next generation of US crewed spacecraft, Orion. These systems improve crew situational awareness and comfort, as well as, insulating the reentry critical components of a spacecraft against the intense thermal environments of atmospheric reentry. Additionally, these materials are highly exposed to space environment hazards like solid particle impacts. This paper discusses impact studies up to 10 km/s on a fused silica window system proposed for the Orion spacecraft. A ballistic limit equation that describes the threshold of perforation of a fuse silica pane over a broad range of impact velocities, obliquities and projectile materials is discussed here.
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- 2015
11. OUTCOMES IN LATER‐LINES OF THERAPY FOR RELAPSED/REFRACTORY FOLLICULAR LYMPHOMA: RESULTS FROM THE INTERNATIONAL SCHOLAR‐5 STUDY
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Ghione, P., primary, Ghesquieres, H., additional, Bobillo, S., additional, Patel, A. R., additional, Kanters, S., additional, Deighton, K., additional, Dong, H., additional, Yang, Y., additional, Ma, L., additional, Limbrick‐Oldfield, E. H., additional, Thornton Snider, J., additional, Wade, S. W., additional, Riberio, M. T., additional, Sudhindra, A., additional, Radford, J., additional, Palomba, M. L., additional, and Gribben, J., additional
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- 2021
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12. Use of failure-to-rescue to identify international variation in postoperative care in low-, middle- and high-income countries
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Ahmad T., Bouwman R. A., Grigoras I., Aldecoa C., Hofer C., Hoeft A., Holt P., Buhre W., Pearse R. M., Clavien P. -A., Demartines N., Grocott M., Haddow J., Moreno R., Pritchard N., Rhodes A., Wilson M., Ahmed T., Halliwell R., Shulman M., Myles P., Schmid W., Hiesmayr M., Wouters P., De Hert S., Lobo S., Beattie S., Wijeysundera D., Fang X., Rasmussen L., Futier E., Biais M., Venara A., Slim K., Sander M., Koulenti D., Arvaniti K., Chan M., Kulkarni A., Chandra S., Tantri A., Geddoa E., Abbas M., Della Rocca G., Sivasakthi D., Mansor M., Luna P., Bouwman A., Beavis V., Campbell D., Short T., Osinaike T., Matos R., Kirov M., Protsenko D., Biccard B., Chew M., Hubner M., Ditai J., Szakmany T., Fleisher L., Ferguson M., MacMahon M., Cherian R., Currow H., Kanathiban K., Gillespie D., Pathmanathan E., Phillips K., Reynolds J., Rowley J., Douglas J., Kerridge R., Garg S., Bennett M., Jain M., Alcock D., Terblanche N., Cotter R., Leslie K., Stewart M., Zingerle N., Clyde A., Hambidge O., Rehak A., Cotterell S., Huynh W. B. Q., McCulloch T., Ben-Menachem E., Egan T., Cope J., Fellinger P., Markus P., Haselberger S., Holaubek C., Lichtenegger P., Scherz F., Hoffer F., Cakova V., Eichwalder A., Fischbach N., Klug R., Schneider E., Vesely M., Wickenhauser R., Gernot K., Leitgeb M., Lang F., Toro N., Bauer M., Laengle F., Haberl C., Mayrhofer T., Trybus C., Buerkle C., Forstner K., Germann R., Rinoesl H., Schindler E., Trampitsch E., Bogner G., Dankl D., Duenser M., Fritsch G., Gradwohl I. -M., Hartmann A., Hoelzenbein T., Jaeger T., Landauer F., Lindl G., Lux M., Steindl J., Stundner O., Szabo C., Bidgoli J., Verdoodt H., Forget P., Kahn D., Lois F., Momeni M., Pregardien C., Pospiech A., Steyaert A., Veevaete L., De Kegel D., De Jongh K., Foubert L., Smitz C., Vercauteren M., Poelaert J., Van Mossevelde V., Abeloos J., Bouchez S., Coppens M., De Baerdemaeker L., Deblaere I., De Bruyne A., Fonck K., Heyse B., Jacobs T., Lapage K., Moerman A., Neckebroek M., Parashchanka A., Roels N., Van Den Eynde N., Vandenheuvel M., Van Limmen J., Vanluchene A., Vanpeteghem C., Wyffels P., Huygens C., Vandenbempt P., Van De Velde M., Dylst D., Janssen B., Schreurs E., Aleixo F. B., Candido K., Batista H. D., Guimaraes M., Guizeline J., Hoffmann J., Lobo F. R. M., Nascimento V., Nishiyama K., Pazetto L., Souza D., Rodrigues R. S., Dos Santos A. M. V., Jardim J., Sa Malbouisson L. M., Silva J., Do Nascimento P., Baio T. H., De Castro G. I. P., Oliveira H. R. W., Amendola C. P., Cardoso G., Ortega D., Brotto A. F., De Oliveira M. C., Rea-Neto A., Dias F., Travi M. E., Zerman L., Azambuja P., Knibel M. F., Martins A., Almeida W., Neto C. N., Tardelli M. A., Caser E., MacHado M., Aguzzoli C., Baldisserotto S., Tabajara F. B., Bettega F., Rodrigues L. H. C., De Gasperi J., Faina L., Nolasco M. F., Da Costa Fischer B. F., De Campos Ferreira M. F., Hartmann C., Kliemann M., Ribeiro G. L. H., Fraga J. M., Netto T. M., Pozza L. V., Wendling P. R., Azevedo C., Garcia J., Lopes M., Maia B., Maselli P., Melo R., Mendes W., Neves M., Ney J., Piras C., Applewhaite C., Carr A., Chow L., Duttchen K., Foglia J., Greene M., Hinther A., Houston K., McCormick T. J., Mikhayel J., Montasser S., Ragan A., Suen A., Woolsey A., Yu H. C., Funk D., Stephen D., Regina D., Heather D., Faisal D., Pridham J., Rowe B., Sampson S., Thiessen B., Zbitnew G., Bernard A., George R., Jones P., Moor R., Siddiqui N., Wolfer A., Tran D., Winch D., Dobson G., Montasser O., Hall R., Baghirzada L., Curley G., Dai S. Y., Hare G., Lee E., Shastri U., Tsui A., Yagnik A., Alvares D., Choi S., Dwyer H., Flores K., McCartney C., Somascanthan P., Carroll J., Pazmino-Canizares J., Ami N., Chan V., Perlas A., Argue R., Huang Y., Lavis K., Mayson K., Cao Y., Gao H., Hu T., Lv J., Yang J., Yang Y., Zhong Y., Zhou J., Zou X., He M., Li X., Luo D., Wang H., Yu T., Chen L., Wang L., Cai Y., Cao Z., Li Y., Lian J., Sun H., Wang S., Wang Z., Wang K., Zhu Y., Du X., Fan H., Fu Y., Huang L., Hwan H., Luo H., Qu P. -S., Tao F., Wang G., Zhang Y., Zhang X., Chen C., Wang W., Liu Z., Fan L., Tang J., Chen Y., Han Y., Huang C., Liang G., Shen J., Wang J., Yang Q., Zhen J., Zhou H., Chen J., Chen Z., Meng B., Ye H., Bi Y., Cao J., Guo F., Lin H., Liu Y., Lv M., Shi P., Song X., Sun C., Sun Y., Wang Y., Zhang M., Chen R., Hou J., Leng Y., Meng Q. -T., Qian L., Shen Z. -Y., Xia Z. -Y., Xue R., Zhao B., Zhou X. -J., Chen Q., Guo H., Guo Y., Qi Y., Wei J., Zhang W., Zheng L., Bao Q., Fei Y., Hu N., Hu X., Lei M., Lv X., Miao F., Ouyang L., Shen C., Wang D., Wu C., Xu L., Yuan J., Zhang L., Zhang H., Zhao J., Zhao C., Zhao L., Zheng T., Zhou D., Zhou C., Lu K., Zhao T., He C., Chen H., Chen S., Cheng B., He J., Jin L., Li C., Li H., Pan Y., Shi Y., Wen X. H., Wu S., Xie G., Zhang K., Lu X., Chen F., Liang Q., Lin X., Ling Y., Liu G., Tao J., Yang L., Cheng Z., Dai H., Feng Y., Hou B., Gong H., Hua C., Huang H., Huang J., Jiang Z., Li M., Lin J., Liu M., Liu W., Luo F., Ma L., Min J., Shi X., Song Z., Wan X., Xiong Y., Yang S., Zhang Q., Zhao W., Zhu X., Bai Y., Dai Q., Geng W., Han K., He X., Ji B., Jia D., Jin S., Li Q., Liang D., Luo S., Lwang L., Mo Y., Qi X., Qian M., Qin J., Ren Y., Xie J., Yan Y., Yao Y., Zhuang X., Ai Y., Du F., He L., Li Z., Li L., Meng S., Yuan Y., Zhang E., Zhang J., Zhao S., Ji Z., Pei L., Dong B., Li J., Miao Z., Mu H., Qin C., Su L., Wen Z., Xie K., Yu Y., Yuan F., Xiao W., Zhu Z., Fu K., Hu R., Huang S., Liang Y., Yu S., Guo Z., Jing Y., Tang N., Wu J., Yuan D., Zhang R., Zhao X., Bai H. -P., Liu C. -X., Liu F. -F., Ren W., Wang X. -L., Xu G. -J., Li B., Ou Y., Tang Y., Yao S., Zhang S., Kong C. -C., Liu B., Wang T., Lu B., Xia Y., Cai F., Chen P., Hu S., Xu Q., Hu L., Jing L., Liu Q., Dan Z., Qiu X., Ren Q., Tong Y., Wen Y., Wu Q., Xia J., Xiong X., Xu S., Yang T., Yin N., Zeng Q., Zhang B., Zheng K., Cang J., Fan Y., Fu S., Ge X., Guo B., Huang W., Jiang L., Jiang X., Shan Q., Wang F., Christiansen I. C., Granum S. N., Rasmussen B. S., Daugaard M., Gambhir R., Brandsborg B., Steingrimsdottir G. E., Jensen-Gadegaard P., Kovgaard K. O., Siegel H., Eskildsen K. Z., Gatke M. R., Wibrandt I., Heintzelmann S. B., Lange K. H. W., Lundsgaard R. S., Amstrup-Hansen L., Hovendal C., Larsen M., Lenstrup M., Kobborg T., Larsen J. R., Pedersen A. B., Smith S. H., Oestervig R. M., Afshari A., Andersen C., Ekelund K., Lilja E., Beloeil H., Lasocki S., Ouattara A., Sineus M., Molliex S., Legouge M. L., Wallet F., Tesniere A., Gaudin C., Lehur P., Forsans E., De Rudnicki S., Maudet V. S., Sojod G., Ouaissi M., Regimbeau J. -M., Desbordes J., Comptaer N., El Manser D., Ethgen S., Lebuffe G., Auer P., Hartl C., Deja M., Legashov K., Sonnemann S., Wiegand-Loehnert C., Falk E., Habicher M., Angermair S., Laetsch B., Schmidt K., Von Heymann C., Ramminger A., Jelschen F., Pabel S., Weyland A., Czeslick E., Gille J., Malcharek M., Sablotzki A., Lueke K., Wetzel P., Weimann J., Lenhart F. -P., Reichle F., Schirmer F., Huppe M., Klotz K., Nau C., Schon J., Mencke T., Wasmund C., Bankewitz C., Baumgarten G., Fleischer A., Guttenthaler V., Hack Y., Kirchgaessner K., Manner O., Schurig-Urbaniak M., Struck R., Van Rebekkazyl, Wittmann M., Goebel U., Harris S., Veit S., Andreadaki E., Souri F., Katsiadramis I., Skoufi A., Vasileiou M., Aimoniotou-Georgiou E., Katsourakis A., Veroniki F., Vlachogianni G., Petra K., Chlorou D., Oloktsidou E., Ourailoglou V., Papapostolou K., Tsaousi G., Daikou P., Dedemadi G., Kalaitzopoulos I., Loumpias C., Bristogiannis S., Dafnios N., Gkiokas G., Kontis E., Kozompoli D., Papailia A., Theodosopoulos T., Bizios C., Koutsikou A., Moustaka A., Plaitakis I., Armaganidis A., Christodoulopoulou T., Lignos M., Theodorakopoulou M., Asimakos A., Ischaki E., Tsagkaraki A., Zakynthinos S., Antoniadou E., Koutelidakis I., Lathyris D., Pozidou I., Voloudakis N., Dalamagka M., Elena G., Chronis C., Manolakaki D., Mosxogiannidis D., Slepova T., Tsakiridou I. -S., Lampiri C., Vachlioti A., Panagiotakis C., Sfyras D., Tsimpoukas F., Tsirogianni A., Axioti E., Filippopoulos A., Kalliafa E., Kassavetis G., Katralis P., Komnos I., Pilichos G., Ravani I., Totis A., Apagaki E., Efthymiadi A., Kampagiannis N., Paraforou T., Tsioka A., Georgiou G., Vakalos A., Bairaktari A., Charitos E., Markou G., Niforopoulou P., Papakonstantinou N., Tsigou E., Xifara A., Zoulamoglou M., Gkioni P., Karatzas S., Kyparissi A., Mainas E., Papapanagiotou I., Papavasilopoulou T., Fragandreas G., Georgopoulou E., Katsika E., Psarras K., Synekidou E., Verroiotou M., Vetsiou E., Zaimi D., Anagnou A., Apostolou K., Melissopoulou T., Rozenberg T., Tsigris C., Boutsikos G., Kalles V., Kotsalas N., Lavdaiou C., Paikou F., Panagou G. -L., Spring A., Botis I., Drimala M., Georgakakis G., Kiourtzieva E., Ntouma P., Prionas A., Xouplidis K., Dalampini E., Giannaki C., Iasonidou C., Ioannidis O., Lavrentieva A., Papageorgiou G., Kokkinoy M., Stafylaraki M., Gaitanakis S., Karydakis P., Paltoglou J., Ponireas P., Chaloulis P., Provatidis A., Sousana A., Gardikou V. V., Konstantivelli M., Lataniotou O., Lisari E., Margaroni M., Stamatiou K., Nikolaidis E., Pnevmatikos I., Sertaridou E., Andreou A., Arkalaki E., Athanasakis E., Chaniotaki F., Chatzimichali C. A., Christofaki M., Dermitzaki D., Fiorentza K., Frantzeskos G., Geromarkaki E., Kafkalaki K., Kalogridaki M., Karydi K., Kokkini S., Kougentakis G., Lefaki T., Lilitsis E., Makatounaki A., Malliotakis P., Michelakis D., Neonaki M., Nyktari V., Palikyra I., Papadakis E., Papaioannou A., Sfakianakis K., Sgouraki M., Souvatzis X., Spartinou A., Stefanidou N., Syrogianni P., Tsagkaraki G., Arnaoutoglou E., Arnaoutoglou C., Bali C., Bouris V., Doumos R., Gkini K. -P., Kapaktsi C., Koulouras V., Lena A., Lepida D., Michos E., Papadopoulos D., Paschopoulos M., Rompou V. A., Siouti I., Tsampalas S., Ververidou O., Zilis G., Charlalampidoy A., Christodoulidis G., Flossos A., Stamoulis K., Tsang M. S. C., Lai M. L., Yip C. P., Chan H. M. H., Law B., Li W. S., Chu H. M., Koo E. G. Y., Lam C. C. J., Cheng K. H., Lam T., Chu S., Lam W. Y., Wong K. W. K., Kwok D., Hung C. Y. J., Chan W. K. J., Wong W. L., Chung C. K. E., Ma S. K., Kaushik S., Shah B., Shah D., Shah S., Ar P., Muthuchellappan R., Agarwal V., Divatia J., Mishra S., Nimje G., Pande S., Savarkar S., Shrivastava A., Thomas M., Yegnaram S., Hidayatullah R., Puar N., Niman S., Indra I., Hamzah Z., Yuliana A., Abidin U. N., Dursin A. N., Kurnia A., Susanti A., Handayani D., Alit M. A., Arya A., Senapathi T. G. A., Utara U. H., Wid W. M., Wima S., Wir W. M., Jehosua B., Kaunang J., Lantang E. Y., Najoan R., Waworuntu N., Awad H., Fuad A., Geddoa B., Khalaf A. R., Al Hussaini S., Albaj S., Kenber M., Bettinelli A., Spadaro S., AlbertoVolta C., Giancarlo L., Sottosanti V., Copetti U. E., Spagnesi L., Toretti I., Alloj C., Cardellino S., Carmino L., Costanzo E., Fanfani L. C., Novelli M. T., Roasio A., Bellandi M. M., Beretta L., Bignami E., Bocchino S., Cabrini L., Corti D., Landoni G., Meroni R., Moizo E., Monti G., Pintaudi M., Plumari V. P., Taddeo D., Testa V., Winterton D., Zangrillo A., Cloro R. L. M., Colangelo C., Colangelo A., Rotunno G., Paludi M. A., Maria C. P., Pata A., Parrini V., Gatta A., Nastasi M., Tinti C., Baroselli A., Arrigo M., Benevento A., Bottini C., Cannavo M., Gastaldi C., Marchesi A., Pascazio A., Pata F., Pozzi E., Premoli A., Tessera G., Boschi L., D'Andrea R., Ghignone F., Poggioli G., Sibilio A., Taffurelli M., Ugolini G., Ab Majid M. A., Ab Rahman R., Joseph J., Pathan F., Shah M. H. S., Yap H. L., Cheah S., Chin I. I., Looi J. K., Tan S. C., Visvalingam S., Kwok F. Y., Lee C. K., Tan T. S., Wong S. M., Abdullah N. H., Liew C. F., Luxuman L., Mohd Zin N. H., Norddin M. F., Alias R. L. R., Wong J. Y., Yong J., Mustapha M. T. B., Chan W. K., Dzulkipli N., Kuan P. X., Lee Y. C., Alias A., Guok E. C., Jee C. C., Ramon B. R., Wong C. W., Abd Ghafar F. N. 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- Subjects
operative ,Male ,Pediatrics ,GLOBAL HEALTH ,Cohort Studies ,0302 clinical medicine ,Postoperative Complications ,030202 anesthesiology ,surgical procedures, operative, mortality ,Health care ,statistics and numerical data ,030212 general & internal medicine ,Hospital Mortality ,Prospective Studies ,Prospective cohort study ,Aged, 80 and over ,HIGH-RISK SURGERY ,COMPLICATIONS ,OUTCOMES ,Incidence (epidemiology) ,Middle Aged ,PATIENT MORTALITY ,Female ,SURGICAL MORTALITY ,Cohort study ,Adult ,medicine.medical_specialty ,methods ,03 medical and health sciences ,Anesthesiology ,medicine ,QUALITY ,Humans ,Elective surgery ,postoperative care, statistics and numerical data ,Aged ,Quality of Health Care ,Postoperative Care ,business.industry ,Postoperative complication ,mortality ,CANCER-SURGERY ,surgical procedures ,Anesthesiology and Pain Medicine ,Logistic Models ,VOLUME ,postoperative care, methods ,Human medicine ,Complication ,business - Abstract
Background.The incidence and impact of postoperative complications are poorly described. Failure-to-rescue, the rate of death following complications, is an important quality measure for perioperative care but has not been investigated across multiple health care systems.Methods.We analysed data collected during the International Surgical Outcomes Study, an international 7-day cohort study of adults undergoing elective inpatient surgery. Hospitals were ranked by quintiles according to surgical procedural volume (Q1 lowest to Q5 highest). For each quintile we assessed in-hospital complications rates, mortality, and failure-to-rescue. We repeated this analysis ranking hospitals by risk-adjusted complication rates (Q1 lowest to Q5 highest).Results.A total of 44 814 patients from 474 hospitals in 27 low-, middle-, and high-income countries were available for analysis. Of these, 7508 (17%) developed one or more postoperative complication, with 207 deaths in hospital (0.5%), giving an overall failure-to-rescue rate of 2.8%. When hospitals were ranked in quintiles by procedural volume, we identified a three-fold variation in mortality (Q1: 0.6% vs Q5: 0.2%) and a two-fold variation in failure-to-rescue (Q1: 3.6% vs Q5: 1.7%). Ranking hospitals in quintiles by risk-adjusted complication rate further confirmed the presence of important variations in failure-to-rescue, indicating differences between hospitals in the risk of death among patients after they develop complications.Conclusions.Comparison of failure-to-rescue rates across health care systems suggests the presence of preventable postoperative deaths. Using such metrics, developing nations could benefit from a data-driven approach to quality improvement, which has proved effective in high-income countries.
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- 2017
13. Body composition differences by age and playing standard in male rugby union and rugby league : A systematic review and meta-analysis
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Geeson-Brown, T, Jones, B, Till, K, Chantler, S, and Deighton, K
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education - Abstract
Objective This systematic review and meta-analysis aimed to determine differences in body composition between playing standard and age in male rugby union and rugby league athletes. Eligibility criteria The MOOSE (Meta-analysis of Observational Studies in Epidemiology) guidelines for design, implementation, and reporting were followed. Studies were required to be in male rugby union or league and have body composition as the primary or secondary outcome. Data was required to be presented separately for positional groups and body composition presented as whole-body. Data sources PubMed, Cochrane Library, MEDLINE, SPORTDiscus, and CINHAHL via EBSCOhost. Risk of bias The methodological quality of the included studies was evaluated using a modified assessment scale Results 58 studies were included for meta-analysis. Results highlighted significantly higher fat-free mass in senior elite than senior sub-elite or junior elite athletes for all RU and RL forwards. Small and non-significant differences were found in fat mass between rugby union playing standards and age categories. Rugby league senior elite forwards had less fat mass than junior elite forwards. Conclusions Practitioners should prioritise training and nutritional strategies that maximise fat-free mass development, especially in junior elite cohorts.
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- 2020
14. Appetite and energy intake responses to breakfast consumption and carbohydrate supplementation in hypoxia
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Griffiths, A, Deighton, K, Shannon, O, Boos, C, Rowe, J, Matu, J, King, R, and O'Hara, J
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- 2020
15. Ballistic Performance Model of Crater Formation in Monolithic, Porous Thermal Protection Systems
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Miller, J. E, Christiansen, E. L, and Deighton, K. D
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Spacecraft Design, Testing And Performance - Abstract
Porous monolithic ablative systems insulate atmospheric reentry vehicles from reentry plasmas generated by atmospheric braking from orbital and exo-orbital velocities. Due to the necessity that these materials create a temperature gradient up to several thousand Kelvin over their thickness, it is important that these materials are near their pristine state prior to reentry. These materials may also be on exposed surfaces to space environment threats like orbital debris and meteoroids leaving a probability that these exposed surfaces will be below their prescribed values. Owing to the typical small size of impact craters in these materials, the local flow fields over these craters and the ablative process afford some margin in thermal protection designs for these locally reduced performance values. In this work, tests to develop ballistic performance models for thermal protection materials typical of those being used on Orion are discussed. A density profile as a function of depth of a typical monolithic ablator and substructure system is shown in Figure 1a.
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- 2014
16. Illness and infection in elite full-contact football-code sports: A systematic review.
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Chesson, L, Whitehead, S, Flanagan, K, Deighton, K, Matu, J, Backhouse, SH, Jones, B, Chesson, L, Whitehead, S, Flanagan, K, Deighton, K, Matu, J, Backhouse, SH, and Jones, B
- Abstract
OBJECTIVES: Full-contact football-code team sports offer a unique environment for illness risk. During training and match-play, players are exposed to high-intensity collisions which may result in skin-on-skin abrasions and transfer of bodily fluids. Understanding the incidence of all illnesses and infections and what impact they cause to time-loss from training and competition is important to improve athlete care within these sports. This review aimed to systematically report, quantify and compare the type, incidence, prevalence and count of illnesses across full-contact football-code team sports. DESIGN/METHODS: A systematic search of Cochrane Library, MEDLINE, SPORTDiscus, PsycINFO and CINAHL electronic databases was performed from inception to October 2019; keywords relating to illness, athletes and epidemiology were used. Studies were excluded if they did not quantify illness or infection, involve elite athletes, investigate full-contact football-code sports or were review articles. RESULTS: Twenty-eight studies met the eligibility criteria. Five different football-codes were reported: American football (n=10), Australian rules football (n=3), rugby league (n=2), rugby sevens (n=3) and rugby union (n=9). One multi-sport study included both American football and rugby union. Full-contact football-code athletes are most commonly affected by respiratory system illnesses. There is a distinct lack of consensus of illness monitoring methodology. CONCLUSIONS: Full-contact football-code team sport athletes are most commonly affected by respiratory system illnesses. Due to various monitoring methodologies, illness incidence could only be compared between studies that used matching incidence exposure measures. High-quality illness surveillance data collection is an essential component to undertake effective and targeted illness prevention in athletes.
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- 2020
17. Carbohydrate supplementation and the influence of breakfast on fuel use in hypoxia
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Griffiths, A, Deighton, K, Boos, C, Rowe, J, Morrison, D, Preston, T, King, R, O'Hara, JP, Griffiths, A, Deighton, K, Boos, C, Rowe, J, Morrison, D, Preston, T, King, R, and O'Hara, JP
- Abstract
Purpose: This study investigated the effect of carbohydrate supplementation on substrate oxidation during exercise in hypoxia after pre-exercise breakfast consumption and omission. Methods: Eleven men walked in normobaric hypoxia (FiO2 ~11.7%) for 90-min at 50% of hypoxic V̇O2max. Participants were supplemented with a carbohydrate beverage (1.2g·min-1 glucose) and a placebo beverage (both enriched with U-13C6 D-glucose) after breakfast consumption and after omission. Indirect calorimetry and isotope ratio mass spectrometry were used to calculate carbohydrate (exogenous and endogenous (muscle and liver)) and fat oxidation. Results: In the first 60-min of exercise, there was no significant change in relative substrate oxidation in the carbohydrate compared with placebo trial after breakfast consumption or omission (both p = 0.99). In the last 30-min of exercise, increased relative carbohydrate oxidation occurred in the carbohydrate compared with placebo trial after breakfast omission (44.0 ± 8.8 vs. 28.0 ± 12.3, p < 0.01) but not consumption (51.7 ± 12.3 vs. 44.2 ± 10.4, p = 0.38). In the same period, a reduction in relative liver (but not muscle) glucose oxidation was observed in the carbohydrate compared with placebo trials after breakfast consumption (liver: 7.7 ± 1.6% vs. 14.8 ± 2.3%, p < 0.01; muscle: 25.4 ± 9.4% vs. 29.4 ± 11.1%, p = 0.99) and omission (liver: 3.8 ± 0.8% vs. 8.7 ± 2.8%, p < 0.01; muscle: 19.4 ± 7.5% vs. 19.2 ± 12.2%, p = 0.99). No significant difference in relative exogenous carbohydrate oxidation was observed between breakfast consumption and omission trials (p = 0.14). Conclusion: In acute normobaric hypoxia, carbohydrate supplementation increased relative carbohydrate oxidation during exercise (> 60 min) after breakfast omission, but not consumption.
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- 2020
18. The Effects of Exercise on Indirect Markers of Gut Damage and Permeability: A Systematic Review and Meta-analysis
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Chantler, S, Griffiths, A, Matu, J, Davison, G, Jones, B, Deighton, K, Chantler, S, Griffiths, A, Matu, J, Davison, G, Jones, B, and Deighton, K
- Abstract
Aim Exercise appears to cause damage to the endothelial lining of the human gastrointestinal tract and elicit a significant increase in gut permeability. Objective The aim of this review was to determine the effect of an acute bout of exercise on gut damage and permeability outcomes in healthy populations using a meta-analysis. Methods PubMed, The Cochrane Library as well as MEDLINE, SPORTDiscus and CINHAL, via EBSCOhost were searched through February 2019. Studies were selected that evaluated urinary (ratio of disaccharide/monosaccharide excretion) or plasma markers [intestinal Fatty Acid Binding Protein (i-FABP)] of gut permeability and gut cell damage in response to a single bout of exercise. Results A total of 34 studies were included. A random-effects meta-analysis was performed, and showed a large and moderate effect size for markers of gut damage (i-FABP) (ES 0.81; 95% CI 0.63–0.98; n = 26; p < 0.001) and gut permeability (Disaccharide Sugar/Monosaccharide Sugar) (ES 0.70; 95% CI 0.29–1.11; n = 17; p < 0.001), respectively. Exercise performed in hot conditions (> 23 °C) further increased markers of gut damage compared with thermoneutral conditions [ES 1.06 (95% CI 0.88–1.23) vs. 0.66 (95% CI 0.43–0.89); p < 0.001]. Exercise duration did not have any significant effect on gut damage or permeability outcomes. Conclusions These findings demonstrate that a single bout of exercise increases gut damage and gut permeability in healthy participants, with gut damage being exacerbated in hot environments. Further investigation into nutritional strategies to minimise gut damage and permeability after exercise is required. PROSPERO database number (CRD42018086339).
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- 2020
19. Galactose Ingested with a High-Fat Beverage Increases Postprandial Lipemia Compared with Glucose but Not Fructose Ingestion in Healthy Men.
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Watkins, J, Simpson, A, Betts, JA, Thompson, D, Holliday, A, Deighton, K, Gonzalez, JT, Watkins, J, Simpson, A, Betts, JA, Thompson, D, Holliday, A, Deighton, K, and Gonzalez, JT
- Abstract
BACKGROUND: Fructose ingestion with a high-fat beverage increases postprandial lipemia when compared with glucose. It is unknown whether other sugars, such as galactose, also increase postprandial lipemia. OBJECTIVES: The objective was to assess whether galactose ingestion within a high-fat beverage increases postprandial lipemia relative to glucose or fructose. METHODS: Two experiments were conducted, which contrasted different test drinks under otherwise standardized conditions. In Experiment 1, 10 nonobese men (age: 22 ± 1 y; BMI, 23.5 ± 2.2 kg/2) ingested either galactose or glucose (0.75 g supplemented carbohydrate per⋅kilogram body mass) within a high-fat test drink (0.94 g fat per kilogram body mass). In Experiment 2, a separate group of 9 nonobese men (age: 26 ± 6 y; BMI: 23.5 ± 2.6 kg/m2) ingested either galactose or fructose (identical doses as those in Experiment 1) within the same high-fat test drink. Capillary blood was sampled before and at frequent intervals after ingestion of the test drinks for a 300-min period to determine plasma triacylglycerol, glucose, lactate, nonesterified fatty acid, and insulin concentrations. Paired t tests and 2-way, repeated-measures ANOVA were used to compare conditions within each experiment. RESULTS: The incremental AUC for triacylglycerol was greater following galactose ingestion compared with glucose (127 ± 59 compared with 80 ± 48 mmol⋅L-1 × 300 min, respectively; P = 0.04) but not compared with fructose (136 ± 74 compared with 133 ± 63 mmol⋅L-1 ×300 min, respectively; P = 0.91). Plasma lactate concentrations also increased to a greater extent with galactose compared with glucose ingestion (time-condition interaction: P < 0.001) but not fructose ingestion (time-condition interaction: P = 0.17). CONCLUSIONS: Galactose ingestion within a high-fat beverage exacerbates postprandial lipemia and plasma lactate concentrations compared with glucose but not fructose in nonobese men. These data suggest that galactose metaboli
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- 2020
20. Incidence, prevalence and consequences of illness in Academy rugby league players
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Chesson, L, Deighton, K, Whitehead, S, Ramirez, C, Jones, B, Chesson, L, Deighton, K, Whitehead, S, Ramirez, C, and Jones, B
- Abstract
Objectives To assess the incidence, prevalence and consequences of illness in one professional academy rugby league club during an in-season period. Design Observational prospective cohort study. Method Seventeen male rugby league players (age 17.7 ± 0.7 years, stature 178.8 ± 5.1 cm, body mass 87.2 ± 9.6 kg) completed a weekly self-report illness questionnaire using an amended version of the Oslo Sports Trauma Research Centre (OSTRC) questionnaire on health problems. Results A total of 24 new illnesses were reported over the 25-week study period. 65% of players experienced at least one illness during the study. The incidence of illness in this cohort was 14.3 per 1000-player days, with the respiratory system being most commonly affected (n = 15; 62.5%). The average weekly illness prevalence was 10.3%. Time-loss illness incidence was 1.4 per 1000-player days. Loss of body mass and sleep disruptions were the most commonly reported consequences of illness episodes. Mean body mass loss during a period of illness was 2.2 ± 0.6 kg. Conclusions Academy rugby league players are most commonly affected by respiratory illness with a total of nineteen training and competition days lost to illness. Associated consequences of illness, such as loss of body mass and sleep disruptions may present a challenge and negatively impact a rugby league player’s development. Appropriate medical provisions should be provided for Academy rugby league players to support them during periods of illness to limit the impact of these consequences.
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- 2020
21. Isolated & combined wearable technology underestimate the total energy expenditure of professional young rugby league players ; a doubly labelled water validation study
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Costello, N, Deighton, K, Whitehead, S, Cummins, C, and Preston, T
- Abstract
Accurately determining total energy expenditure enables the precise manipulation of energy balance within professional collision-based sports. Therefore, this study investigated the ability of isolated or combined wearable technology to determine the total energy expenditure of professional young rugby league players across a typical pre-season and in-season period. Total energy expenditure was measured via doubly labelled water, the criterion method, across a fourteen-day pre-season (n=6) and seven-day in-season (n=7) period. Practical measures of total energy expenditure included SenseWear Pro3 Armbands in isolation and combined with metabolic power derived from microtechnology units. SenseWear Pro3 Armbands significantly under-reported pre-season (5.00 (2.52) MJ.day-1; p = 0.002) and in-season (2.86 (1.15) MJ.day-1; p < 0.001) total energy expenditure, demonstrating a large and extremely large standardised mean bias, and a very large and large typical error, respectively. Combining metabolic power with SenseWear Pro3 Armbands almost certainly improved pre-season (0.95 (0.15) MJ.day-1; ES = 0.32 ±0.04; p < 0.001) and in-season (1.01 (0.15) MJ.day-1; ES = 0.88 ±1.05; p < 0.001) assessment. However, SenseWear Pro3 Armbands combined with metabolic power continued to significantly under-report pre-season (4.04 (2.38) MJ.day-1; p = 0.004) and in-season (2.18 (0.96) MJ.day-1; p = 0.002) expenditure, demonstrating a large and very large standardised mean bias, and a very large and large typical error, respectively. These findings demonstrate the limitations of utilising isolated or combined wearable technology to accurately determine the total energy expenditure of professional collision-based sport athletes across different stages of the season.
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- 2019
22. Orion Spacecraft MMOD Protection Design and Assessment
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Bohl, W, Miller, J, Deighton, K, Yasensky, J, Foreman C, Christiansen, Eric, Hyde, J, and Nahra, H
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Spacecraft Design, Testing And Performance - Abstract
The Orion spacecraft will replace the Space Shuttle Orbiter for American and international partner access to the International Space Station by 2015 and, afterwards, for access to the moon for initial sorties and later for extended outpost visits as part of the Constellation Exploration Initiative. This work describes some of the efforts being undertaken to ensure that the Constellation Program, Orion Crew Exploration Vehicle design will meet or exceed the stringent micrometeoroid and orbital debris (MMOD) requirements set out by NASA when exposed to the environments encountered with these missions. This paper will provide a brief overview of the approaches being used to provide MMOD protection to the Orion vehicle and to assess the spacecraft for compliance to the Constellation Program s MMOD requirements.
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- 2010
23. Erythropoietic responses to a series of repeated maximal dynamic and static apnoeas in elite and non-breath-hold divers
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Elia, A, Barlow, M, Wilson, O, Deighton, K, and O'Hara, JP
- Abstract
Serum erythropoietin (EPO) concentration is increased following static apnoea-induced hypoxia. However, the acute erythropoietic responses to a series of dynamic apnoeas in non-divers (ND) or elite breath-hold divers (EBHD) are unknown. Participants were stratified into EBHD (n=8), ND (n=10) and control (n=8) groups. On two separate occasions EBHD and ND performed a series of five maximal dynamic apnoeas (DYN) or two sets of five maximal static apnoeas (STA). Control performed a static eupnoeic (STE) protocol to control against any effects of water immersion and diurnal variation on EPO. Peripheral oxygen saturation (SpO2) levels were monitored up to 20s post each maximal effort. Blood samples were collected at 30, 90, and 180-min after each protocol for EPO, haemoglobin and haematocrit concentrations. No between group differences were observed at baseline (p>0.05). For EBHD and ND, mean end-apnoea SpO2 was lower in DYN (EBHD,62±10%,p=0.024;ND,85±6%;p=0.020) than STA (EBHD,76±7%;ND,96±1%) and control (98±1%) protocols. EBHD attained lower end-apnoeic SpO2 during DYN and STA than ND (p
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- 2019
24. ‘Academic Periodisation’: Using approaches from elite sport to benefit early career academics
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Deighton, K and Gonzalez, J
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- 2019
25. Effects of emotional intelligence and supportive text messages on academic outcomes in first year undergraduates
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Deighton, K, Hudson, J, Manley, AJ, Kaiseler, M, Patterson, LB, Rutherford, ZH, and Swainson, M
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An increase in the number of students entering higher education has intensified the need for 26 targeted strategies to support a wider range of student requirements. Current research suggests 27 that emotional intelligence (EI) may be associated with academic success, progression and 28 retention in university students but the use of EI screening as a prospective measure of success 29 requires further investigation. This study evaluates the utility of prospective EI screening to 30 predict progression rates, mean grades, attendance and online engagement in a sample of first 31 year undergraduate students enrolled on the same degree programme (n=358). A supportive 32 text messaging intervention was employed during potentially stressful periods of the academic 33 year in a subsection of participants (n=60) that demonstrated low total EI scores relative to the 34 cohort. Results showed no effects of EI classification on progression rates, mean grades, 35 attendance and online engagement (all P>0.418). Alternatively, the text messaging intervention 36 was associated with significant improvements compared with a matched control group for 37 progression rates (P=0.027), mean grades (P=0.026) and attendance (P=0.007). The frequency 38 of access to the virtual learning environment also tended to be higher in the intervention group 39 compared with the control group (P=0.059). In conclusion, this study did not identify any 40 benefits of EI screening as a prospective indicator of student success but provides encouraging 41 indications that a text messaging support intervention could help to improve progression rates, 42 mean grades, attendance and online engagement in first year undergraduate students. Further 43 research is warranted to develop these proof-of-concept findings.
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- 2019
26. Can a contemporary dietary assessment tool or wearable technology accurately assess the energy intake of professional young rugby league players? A doubly labelled water validation study
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Costello, N, Deighton, K, Dalton-Barron, N, Whitehead, S, Preston, T, Jones, B, Costello, N, Deighton, K, Dalton-Barron, N, Whitehead, S, Preston, T, and Jones, B
- Abstract
Accurate quantification of energy intake is imperative in athletes; however traditional dietary assessment tools are frequently inaccurate. Therefore, this study investigated the validity of a contemporary dietary assessment tool or wearable technology to determine the total energy intake (TEI) of professional young athletes. The TEI of eight professional young male rugby league players was determined by three methods; Snap-N-Send, SenseWear Armbands (SWA) combined with metabolic power and doubly labelled water (DLW; intake-balance method; criterion) across a combined ten-day pre-season and seven-day in-season period. Changes in fasted body mass were recorded, alongside changes in body composition via isotopic dilution and a validated energy density equation. Energy intake was calculated via the intake-balance method. Snap-N-Send non-significantly over-reported pre-season and in-season energy intake by 0.21 (2.37) MJ.day-1 (p = 0.833) and 0.51 (1.73) MJ.day-1 (p = 0.464), respectively. This represented a trivial and small standardised mean bias, and very large and large typical error. SenseWear Armbands and metabolic power significantly under-reported pre-season and in-season TEI by 3.51 (2.42) MJ.day-1 (p = 0.017) and 2.18 (1.85) MJ.day-1 (p = 0.021), respectively. This represents a large and moderate standardised mean bias, and very large and very large typical error. There was a most likely larger daily error reported by SWA and metabolic power than Snap-N-Send across pre-season (3.30 (2.45) MJ.day-1; ES = 1.26 ± 0.68; p = 0.014) and in-season periods (1.67 (2.00) MJ.day-1; ES = 1.27 ± 0.70; p = 0.012). This study demonstrates the enhanced validity of Snap-N-Send for assessing athlete TEI over combined wearable technology, although caution is required when determining the individual TEIs of athletes via Snap-N-Send.
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- 2019
27. Differences in circulating appetite-related hormone concentrations between younger and older adults : a systematic review and meta-analysis
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Johnson, KO, Shannon, OM, Matu, J, Holliday, A, Ispoglou, T, Deighton, K, Johnson, KO, Shannon, OM, Matu, J, Holliday, A, Ispoglou, T, and Deighton, K
- Abstract
Ageing is associated with reduced appetite and energy intakes. However, the mechanisms underlying this phenomenon are not fully understood. This systematic review and meta-analysis quantified differences in circulating concentrations of appetite-related hormones between healthy older and younger adults. Six databases were searched through 12th June 2018 for studies that compared appetite-related hormone concentrations between older and younger adults. Data were pooled using random-effects meta-analysis and are presented as standardised mean difference (Hedges' g) with 95% confidence intervals (95% CI). Thirty-five studies were included involving 710 older adults (mean ± SD; age: 73 ± 5 years) and 713 younger adults (age: 28 ± 7 years). Compared with younger adults, older adults exhibited higher fasted and postprandial concentrations of the anorectic hormones cholecystokinin (Fasted: SMD 0.41 (95% CI 0.24, 0.57); p < 0.001. Postprandial: SMD 0.41 (0.20, 0.62); p < 0.001), leptin [Fasted: SMD 1.23 (0.15, 2.30); p = 0.025. Postprandial: SMD 0.62 (0.23, 1.01); p = 0.002] and insulin [Fasted: SMD 0.24 (- 0.02, 0.50); p = 0.073. Postprandial: SMD 0.16 (0.01, 0.32); p = 0.043]. Higher postprandial concentrations of peptide-YY were also observed in older adults compared with younger adults [SMD 0.31 (- 0.03, 0.65); p = 0.075]. Compared with younger adults, older adults had lower energy intakes [SMD - 0.98 (- 1.74, - 0.22); p = 0.011], and lower hunger perceptions in the fasted [SMD - 1.00 (- 1.54, - 0.46); p < 0.001] and postprandial states [SMD - 0.31, (- 0.64, 0.02); p = 0.064]. Higher circulating concentrations of insulin, leptin, cholecystokinin and peptide-YY accord with reduced appetite and energy intakes in healthy older adults. Interventions to reduce circulating levels of these hormones may be beneficial for combatting the anorexia of ageing.
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- 2019
28. Response : Commentary on the effects of hypoxia on energy substrate use during exercise
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Griffiths, A, Shannon, O, Matu, J, King, R, Deighton, K, O'Hara, JP, Griffiths, A, Shannon, O, Matu, J, King, R, Deighton, K, and O'Hara, JP
- Abstract
BACKGROUND: A recent commentary has been published on our meta-analysis, which investigated substrate oxidation during exercise matched for relative intensities in hypoxia compared with normoxia. Within this commentary, the authors proposed that exercise matched for absolute intensities in hypoxia compared with normoxia, should have been included within the analysis, as this model provides a more suitable experimental design when considering nutritional interventions in hypoxia. MAIN BODY: Within this response, we provide a rationale for the use of exercise matched for relative intensities in hypoxia compared with normoxia. Specifically, we argue that this model provides a physiological stimulus replicable of real world situations, by reducing the absolute workload undertaken in hypoxia. Further, the use of exercise matched for relative intensities isolates the metabolic response to hypoxia, rather than the increased relative exercise intensity experienced in hypoxia when utilising exercise matched for absolute intensities. In addition, we also report previously unpublished data analysed at the time of the original meta-analysis, assessing substrate oxidation during exercise matched for absolute intensities in hypoxia compared with normoxia. CONCLUSION: An increased reliance on carbohydrate oxidation was observed during exercise matched for absolute intensities in hypoxia compared with normoxia. These data now provide a comparable dataset for the use of researchers and practitioners alike in the design of nutritional interventions for relevant populations.
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- 2019
29. Substrate oxidation and the influence of breakfast in normobaric hypoxia and normoxia
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Griffiths, A, Deighton, K, Shannon, O, Matu, J, King, R, O'Hara, JP, Griffiths, A, Deighton, K, Shannon, O, Matu, J, King, R, and O'Hara, JP
- Abstract
Purpose: Reported substrate oxidation responses in hypoxia are divergent, and may be due to differences in methodological design, such as pre-exercise nutritional status and exercise intensity. This study investigated the effect of breakfast consumption versus omission on substrate oxidation at varying exercise intensities in normobaric hypoxia compared with normoxia. Methods: Twelve participants rested and exercised once after breakfast consumption and once after omission in normobaric hypoxia (4300 m: FiO2 ~11.7%) and normoxia. Exercise consisted of walking for 20-minutes at 40%, 50% and 60% of altitude-specific V̇O2max at 10-15% gradient with a 10 kg backpack. Indirect calorimetry was used to calculate carbohydrate and fat oxidation. Results: The relative contribution of carbohydrate oxidation to energy expenditure was significantly reduced in hypoxia compared with normoxia during exercise after breakfast omission at 40% (22.4 ± 17.5% vs. 38.5±15.5%, p = 0.03) and 60% V̇O2max (35.4±12.4 vs. 50.1±17.6%, p = 0.03), with a trend observed at 50% V̇O2max (23.6±17.9% vs. 38.1± 17.0%, p = 0.07). The relative contribution of carbohydrate oxidation to energy expenditure was not significantly different in hypoxia compared with normoxia during exercise after breakfast consumption at 40% (42.4±15.7% vs. 48.5±13.3%, p = 0.99), 50% (43.1±11.7% vs. 47.1±14.0%, p = 0.99) and 60% V̇O2max (54.6±17.8% vs. 55.1±15.0%, p = 0.99). Conclusions: Relative carbohydrate oxidation was significantly reduced in hypoxia compared with normoxia during exercise after breakfast omission but not during exercise after breakfast consumption. This response remained consistent with increasing exercise intensities. These findings may explain some of the disparity in the literature
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- 2019
30. Three-day changes in resting metabolism after a professional young rugby league match
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Costello, NB, Deighton, K, Dalton-Barron, N, Whitehead, S, Mclaren, S, Jones, B, Costello, NB, Deighton, K, Dalton-Barron, N, Whitehead, S, Mclaren, S, and Jones, B
- Abstract
Professional collision-sport athletes report uniquely large energy expenditures across the season (1-4), as determined by gold standard assessment of resting metabolic rate (RMR (5)) and total energy expenditure (TEE (6)). Such expenditures are possibly a consequence of strenuous match demands, which repeatedly expose players to substantial exercise-and collision-induced muscle damage (7). Recovery from such large perturbations of homeostasis (8) are likely to be energetically expensive (9), in part determining the distinct in-season energetic demands of professional collision-sport athletes. Aim. Accurately determining the effect of match play on resting metabolism is essential to optimise acute manipulation of energy balance, player recovery and long-term athlete development. Therefore, for the first time this case report investigated the metabolic cost of a professional young rugby league match.
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- 2019
31. A single day of mixed-macronutrient overfeeding does not elicit compensatory appetite or energy intake responses but exaggerates postprandial lipemia during the next day in healthy young men
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Deighton, K, King, A, Matu, J, Shannon, O, Whiteman, O, Long, A, Huby, MD, Sekula, M, Holliday, A, Deighton, K, King, A, Matu, J, Shannon, O, Whiteman, O, Long, A, Huby, MD, Sekula, M, and Holliday, A
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- 2019
32. The effects of environmental hypoxia on substrate utilisation during exercise : A meta-analysis
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Griffiths, A, Shannon, O, Matu, J, King, R, Deighton, K, O'Hara, J, Griffiths, A, Shannon, O, Matu, J, King, R, Deighton, K, and O'Hara, J
- Abstract
Background: A better understanding of hypoxia-induced changes in substrate utilisation can facilitate the development of nutritional strategies for mountaineers, military personnel and athletes during exposure to altitude. However, reported metabolic responses are currently divergent. As such, this systematic review and meta-analysis aims to determine the changes in substrate utilisation during exercise in hypoxia compared with normoxia and identify study characteristics responsible for the heterogeneity in findings. Methods: A total of six databases (PubMed, the Cochrane Library, MEDLINE, SPORTDiscus, PsychINFO, and CINAHL via EBSCOhost) were searched for published original studies, conference proceedings, abstracts, dissertations and theses. Studies were included if they evaluated respiratory exchange ratio (RER) and/or carbohydrate or fat oxidation during steady state exercise matched for relative intensities in normoxia and hypoxia (normobaric or hypobaric). A random-effects meta-analysis was performed on outcome variables. Meta-regression analysis was performed to investigate potential sources of heterogeneity. Results: In total, 18 studies were included in the meta-analysis. There was no significant change in RER during exercise matched for relative exercise intensities in hypoxia, compared with normoxia (mean difference: 0.01, 95% CI: -0.02 to 0.05; n = 31, p = 0.45). Meta-regression analysis suggests that consumption of a pre-exercise meal (p < 0.01) and a higher exercise intensity (p = 0.04) when exposed to hypoxia may increase carbohydrate oxidation compared with normoxia. Conclusions: Exposure to hypoxia did not induce a consistent change in the relative contribution of carbohydrate or fat to the total energy yield during exercise matched for relative intensities, compared with normoxia. The direction of these responses appears to be mediated by the consumption of a pre-exercise meal and exercise intensity. Key words: Altitude, exercise, substrate, carboh
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- 2019
33. Associations between the rate, amount and composition of weight loss as predictors of spontaneous weight regain in adults achieving clinically significant weight loss: a systematic review and meta-regression
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Turicchi, J, O'Driscoll, R, Finlayson, G, Beaulieu, K, Deighton, K, Stubbs, J, Turicchi, J, O'Driscoll, R, Finlayson, G, Beaulieu, K, Deighton, K, and Stubbs, J
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- 2019
34. Changes In Jump Performance And Dynamic Balance At High Terrestrial Altitude
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VanSumeren, A, Breen, S, Deighton, K, and O'Hara, JP
- Abstract
The purpose of this study was to examine the effects of altitude on dynamic balance and jump performance of a controlled landing during a 12-day high altitude trek. Following a two-legged jump, time to stabilization (5% of body mass for 0.5 s), maximum power, and jump height were measured in 11 participants using a portable force platform at sea level (BL), 3619 m (C1), and 5140 m (C3). Jump performance significantly decreased at C1 and C3 compared to BL (P=0.001). There were no significant differences found in time to stabilization and maximum power with increasing altitude. The present findings indicate that jump performance is significantly decreased with increasing altitude. However, dynamic balance and jump power remain unaffected.
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- 2018
35. How well do activity monitors estimate energy expenditure? A systematic review and meta-analysis
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O’Driscoll, R, Turicchi, J, Beaulieu, K, Scott, S, Matu, J, Deighton, K, Finlayson, G, and Stubbs, RJ
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- 2018
36. Continuous Glucose Monitoring at High Altitude—Effects on Glucose Homeostasis
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Hill, NE, Deighton, K, Matu, J, Misra, S, Oliver, NS, Newman, C, Mellor, A, O'Hara, J, and Woods, D
- Abstract
Purpose: Exposure to high altitude has been shown to enhance both glucose and lipid utilization depending on experimental protocol. In addition, high and low blood glucose levels have been reported at high altitude. We hypothesized that gradual ascent to high altitude results in changes in glucose levels in healthy young adults.\ud \ud \ud \ud Methods: Twenty-five adult volunteers, split into two teams, took part in the British Services Dhaulagiri Medical Research Expedition completing 14 d of trekking around the Dhaulagiri circuit in Nepal reaching a peak altitude of 5300 m on day 11 of the trek. Participants wore blinded continuous glucose monitors (CGM) throughout. Blood samples for C-peptide, proinsulin, and triacylglycerides were taken at sea level (United Kingdom) and in acclimatization camps at 3600, 4650, and 5120 m. Energy intake was determined from food diaries.\ud \ud \ud \ud Results: There was no difference in time spent in hypoglycemia stratified by altitude. Nocturnal CGM readings (2200–0600 h) were chosen to reduce the short-term effect of physical activity and food intake and showed a significant (P < 0.0001) increase at 3600 m (5.53 ± 0.22 mmol·L−1), 4650 m (4.77 ± 0.30 mmol·L−1), and 5120 m (4.78 ± 0.24 mmol·L−1) compared with baseline altitude 1100 m (vs 4.61 ± 0.25 mmol·L−1). Energy intake did not differ by altitude. Insulin resistance and beta-cell function, calculated by homeostatic model assessment, were reduced at 3600 m compared with sea level.\ud \ud \ud \ud Conclusions: We observed a significant increase in nocturnal CGM glucose at 3600 m and greater despite gradual ascent from 1100 m. Taken with the changes in insulin resistance and beta-cell function, it is possible that the stress response to high altitude dominates exercise-enhanced insulin sensitivity, resulting in relative hyperglycemia.
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- 2018
37. Continuous Glucose Monitoring – effects of altitude on glucose and glycaemic variability
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Hill, N, Deighton, K, Matu, J, Misra, S, Oliver, N, Newman, C, Mellor, A, O'Hara, JP, and Woods, D
- Abstract
Purpose: Exposure to high altitude has been shown to enhance both glucose and lipid utilization depending on experimental protocol. In addition, high and low blood glucose levels have been reported at high altitude. We hypothesized that gradual ascent to high altitude results in changes in glucose levels in healthy young adults. Methods: 25 adult volunteers, split into two teams, took part in the British Services Dhaulagiri Medical Research Expedition completing 14 days of trekking around the Dhaulagiri circuit in Nepal reaching a peak altitude of 5300m on Day 11 of the trek. Participants wore blinded continuous glucose monitors (CGM) throughout. Blood samples for c-peptide, pro-insulin and triacylglycerides were taken at sea level (UK) and in acclimatisation camps at 3600m, 4650m and 5120m. Energy intake was determined from food diaries. Results: There was no difference in time spent in hypoglycemia stratified by altitude. Nocturnal CGM readings (22.00-06.00 hrs) were chosen to reduce the short-term impact of physical activity and food intake and showed a significant (p
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- 2018
38. Collision activity during training increases total energy expenditure measured via doubly labelled water
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Costello, NB, Deighton, K, Preston, T, Matu, J, Rowe, J, Sawczuk, T, Halkier, M, Read, D, Weaving, D, Jones, B, Costello, NB, Deighton, K, Preston, T, Matu, J, Rowe, J, Sawczuk, T, Halkier, M, Read, D, Weaving, D, and Jones, B
- Abstract
Purpose: Collision sports are characterised by frequent high intensity collisions that induce substantial muscle damage, potentially increasing the energetic cost of recovery. Therefore, this study investigated the energetic cost of collision-based activity for the first time across any sport. Methods: Using a randomised crossover design, six professional young male rugby league players completed two different five-day pre-season training microcycles. Players completed either a collision (COLL; 20 competitive one-on-one collisions) or non-collision (nCOLL; matched for kinematic demands, excluding collisions) training session on the first day of each microcycle, exactly seven days apart. All remaining training sessions were matched and did not involve any collision-based activity. Total energy expenditure was measured using doubly labelled water, the literature gold standard. Results: Collisions resulted in a very likely higher (4.96 ± 0.97 MJ; ES = 0.30 ±0.07; p=0.0021) total energy expenditure across the five-day COLL training microcycle (95.07 ± 16.66 MJ) compared with the nCOLL training microcycle (90.34 ± 16.97 MJ). The COLL training session also resulted in a very likely higher (200 ± 102 AU; ES = 1.43 ±0.74; p=0.007) session rating of perceived exertion and a very likely greater (-14.6 ± 3.3%; ES = -1.60 ±0.51; p=0.002) decrease in wellbeing 24h later. Conclusions: A single collision training session considerably increased total energy expenditure. This may explain the large energy expenditures of collision sport athletes, which appear to exceed kinematic training and match demands. These findings suggest fuelling professional collision-sport athletes appropriately for the "muscle damage caused” alongside the kinematic “work required”.
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- 2018
39. Are professional young rugby league players eating enough? Energy intake, expenditure and balance during a pre-season.
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Costello, NB, Deighton, K, Preston, T, Matu, J, Rowe, J, Jones, B, Costello, NB, Deighton, K, Preston, T, Matu, J, Rowe, J, and Jones, B
- Abstract
Due to the unique energetic demands of professional young collision sport athletes, accurate assessment of energy balance is required. Consequently, this is the first study to simultaneously investigate the energy intake, expenditure and balance of professional young rugby league players across a pre-season period. The total energy expenditure of six professional young male rugby league players was measured via doubly labelled water over a fourteen-day assessment period. Resting metabolic rate was measured and physical activity level calculated. Dietary intake was reported via Snap-N-Send over a non-consecutive ten-day assessment period, alongside changes in fasted body mass and hydration status. Accordingly, energy balance was inferred. The mean (standard deviation) difference between total energy intake (16.73 (1.32) MJ.day-1) and total energy expenditure (18.36 (3.05) MJ.day-1) measured over the non-consecutive ten-day period was unclear (-1.63 (1.73) MJ.day-1; ES = 0.91 ±1.28; p = 0.221). This corresponded in a most likely trivial decrease in body mass (-0.65 (0.78) kg; ES = 0.04 ±0.03; p = 0.097). Resting metabolic rate and physical activity level across the fourteen-day pre-season period was 11.20 (2.16) MJ.day-1 and 1.7 (0.2), respectively. For the first time, this study utilises gold standard assessment techniques to elucidate the distinctly large energy expenditures of professional young rugby league players across a pre-season period, emphasising a requirement for equally large energy intakes to achieve targeted body mass and composition adaptations. Accordingly, it is imperative that practitioners regularly assess the energy balance of professional young collision-sport athletes to ensure their unique energetic requirements are achieved.
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- 2018
40. Omega-3 polyunsaturated fatty acids favourably modulate cardiometabolic biomarkers in type 2 diabetes: a meta-analysis and meta-regression of randomized controlled trials
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O'Mahoney, L, Matu, J, Price, OJ, Birch, KM, Ajjan, RA, Farrar, D, Tapp, R, West, D, Deighton, K, Campbell, MD, O'Mahoney, L, Matu, J, Price, OJ, Birch, KM, Ajjan, RA, Farrar, D, Tapp, R, West, D, Deighton, K, and Campbell, MD
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- 2018
41. Acute and Chronic Effects of Exercise on Appetite, Energy Intake, and Appetite-Related Hormones: The Modulating Effect of Adiposity, Sex, and Habitual Physical Activity.
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Dorling, J, Broom, DR, Burns, SF, Clayton, DJ, Deighton, K, James, LJ, King, JA, Miyashita, M, Thackray, AE, Batterham, RL, Stensel, DJ, Dorling, J, Broom, DR, Burns, SF, Clayton, DJ, Deighton, K, James, LJ, King, JA, Miyashita, M, Thackray, AE, Batterham, RL, and Stensel, DJ
- Abstract
Exercise facilitates weight control, partly through effects on appetite regulation. Single bouts of exercise induce a short-term energy deficit without stimulating compensatory effects on appetite, whilst limited evidence suggests that exercise training may modify subjective and homeostatic mediators of appetite in directions associated with enhanced meal-induced satiety. However, a large variability in responses exists between individuals. This article reviews the evidence relating to how adiposity, sex, and habitual physical activity modulate exercise-induced appetite, energy intake, and appetite-related hormone responses. The balance of evidence suggests that adiposity and sex do not modify appetite or energy intake responses to acute or chronic exercise interventions, but individuals with higher habitual physical activity levels may better adjust energy intake in response to energy balance perturbations. The effect of these individual characteristics and behaviours on appetite-related hormone responses to exercise remains equivocal. These findings support the continued promotion of exercise as a strategy for inducing short-term energy deficits irrespective of adiposity and sex, as well as the ability of exercise to positively influence energy balance over the longer term. Future well-controlled studies are required to further ascertain the potential mediators of appetite responses to exercise.
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- 2018
42. The effects of hypoxia on hunger perceptions, appetite-related hormone concentrations, and energy intake: a systematic review and meta-analysis
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Matu, J, Gonzalez, JT, Ispoglou, T, Duckworth, L, Deighton, K, Matu, J, Gonzalez, JT, Ispoglou, T, Duckworth, L, and Deighton, K
- Abstract
Exposure to hypoxia appears to depress appetite and energy intake, however the mechanisms are not fully understood. The aim of this review was to determine the magnitude of changes in hunger and energy intake in hypoxic compared with normoxic environments, and establish any alterations in appetite-related hormone concentrations. PubMed and The Cochrane Library as well as MEDLINE, SPORTDiscus, PsycINFO and CINAHL, via EBSCOhost, were searched through 1st April 2017 for studies that evaluated hunger, energy intake and/or appetite-related hormones in normoxia and during hypoxic exposure in a within-measures design. A total of 28 studies (comprising 54 fasted and 22 postprandial comparisons) were included. A random-effects meta-analysis was performed to establish standardised mean difference (SMD) with 95% confidence intervals. Hypoxic exposure resulted in a trivial but significant decrease in postprandial hunger scores (SMD: -0.15, 95% CI: -0.29 to -0.01; n = 14; p = 0.043) and a moderate decrease in energy intake (SMD: -0.50, 95% CI: -0.85 to -0.15; n = 8; p = 0.006). Hypoxic exposure resulted in a decrease (albeit trivial) in postprandial acylated ghrelin concentrations (SMD: -0.16, 95% CI: -0.25 to -0.08; n = 7; p < 0.0005), and a moderate increase in fasted insulin concentrations (SMD: 0.41, 95% CI: 0.17 to 0.65; n = 34; p = 0.001). Meta-regression revealed a decrease in postprandial acylated ghrelin concentrations (p = 0.010) and an increase in fasted insulin concentrations (p = 0.020) as hypoxic severity increased. Hypoxic exposure reduces hunger and energy intake, which may be mediated by decreased circulating concentrations of acylated ghrelin and elevated insulin concentrations. PROSPERO registration number: CRD42015017231.
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- 2018
43. Changes in balance and joint position sense during a 12-day high altitude trek: The British Services Dhaulagiri medical research expedition
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Clarke, SB, Deighton, K, Newman, C, Nicholson, G, Gallagher, L, Boos, C, Mellor, A, Woods, D, O'Hara, JP, Clarke, SB, Deighton, K, Newman, C, Nicholson, G, Gallagher, L, Boos, C, Mellor, A, Woods, D, and O'Hara, JP
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- 2018
44. The British Services Dhaulagiri Medical Research Expedition 2016 : a unique military and civilian research collaboration
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Mellor, A, Bakker-Dyos, J, Howard, M, Boos, C, Cooke, M, Vincent, E, Scott, P, O'Hara, J, Clarke, S, Barlow, M, Matu, J, Deighton, K, Hill, N, Newman, C, Cruttenden, R, Holdsworth, D, and Woods, D
- Abstract
The British Service Dhaulagiri Research Expedition took place in March-May 2016. A total of 129 personnel took part in the expedition and were invited to consent to a variety of study protocols investigating adaptation to high altitudes and diagnosis of altitude illness. The study took place in a remote and inhospitable environment at altitudes up to 7500m. This paper gives an overview of the challenges involved, the research protocols investigated and the execution of the expedition in Nepal.
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- 2017
45. In-hospital clinical outcomes after upper gastrointestinal surgery: Data from an international observational study
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Ahmad, T, Bouwman, RA, Grigoras, I, Aldecoa, C, Hofer, C, Hoeft, A, Holt, P, Fleisher, LA, Buhre, W, Pearse, RM, Ferguson, M, MacMahon, M, Shulman, M, Cherian, R, Currow, H, Kanathiban, K, Gillespie, D, Pathmanathan, E, Phillips, K, Reynolds, J, Rowley, J, Douglas, J, Kerridge, R, Garg, S, Bennett, M, Jain, M, Alcock, D, Terblanche, N, Cotter, R, Leslie, K, Stewart, M, Zingerle, N, Clyde, A, Hambidge, O, Rehak, A, Cotterell, S, Huynh, WBQ, McCulloch, T, Ben-Menachem, E, Egan, T, Cope, J, Halliwell, R, Fellinger, P, Haisjackl, M, Haselberger, S, Holaubek, C, Lichtenegger, P, Scherz, F, Schmid, W, Hoffer, F, Cakova, V, Eichwalder, A, Fischbach, N, Klug, R, Schneider, E, Vesely, M, Wickenhauser, R, Grubmueller, KG, Leitgeb, M, Lang, F, Toro, N, Bauer, M, Laengle, F, Haberl, C, Mayrhofer, T, Trybus, C, Buerkle, C, Forstner, K, Germann, R, Rinoesl, H, Schindler, E, Trampitsch, E, Bogner, G, Dankl, D, Duenser, M, Fritsch, G, Gradwohl-Matis, I, Hartmann, A, Hoelzenbein, T, Jaeger, T, Landauer, F, Lindl, G, Lux, M, Steindl, J, Stundner, O, Szabo, C, Bidgoli, J, Verdoodt, H, Forget, P, Kahn, D, Lois, F, Momeni, M, Pregardien, C, Pospiech, A, Steyaert, A, Veevaete, L, De Kegel, D, De Jongh, K, Foubert, L, Smitz, C, Vercauteren, M, Poelaert, J, Van Mossevelde, V, Abeloos, J, Bouchez, S, Coppens, M, De Baerdemaeker, L, Deblaere, I, De Bruyne, A, De Hert, S, Fonck, K, Heyse, B, Jacobs, T, Lapage, K, Moerman, A, Neckebroek, M, Parashchanka, A, Roels, N, Van Den Eynde, N, Vandenheuvel, M, Van Limmen, J, Vanluchene, A, Vanpeteghem, C, Wouters, P, Wyffels, P, Huygens, C, Vandenbempt, P, Van de Velde, M, Dylst, D, Janssen, B, Schreurs, E, Aleixo, FB, Candido, K, Batista, HD, Guimaraes, M, Guizeline, J, Hoffmann, J, Lobo, S, Marques Lobo, FR, Nascimento, V, Nishiyama, K, Pazetto, L, Souza, D, Rodrigues, RS, Vilela dos Santos, AM, Jardim, J, Sa Malbouisson, LM, Silva, J, do Nascimento Junior, P, Baio, TH, Pereira de Castro, GI, Watanabe Oliveira, HR, Amendola, CP, Cardoso, G, Ortega, D, Brotto, AF, De Oliveira, MC, Rea-Neto, A, Dias, F, Travi, ME, Zerman, L, Azambuja, P, Knibel, MF, Martins, A, Almeida, W, Neder Neto, C, Tardelli, MA, Caser, E, Machado, M, Aguzzoli, C, Baldisserotto, S, Tabajara, FB, Bettega, F, Rodrigues Junior, LHC, de Gasperi, J, Faina, L, Nolasco, MF, da Costa Fischer, BF, de Campos Ferreira, MF, Hartmann, C, Kliemann, M, Ribeiro, GLH, Fraga, JM, Netto, TM, Pozza, LV, Wendling, PR, Azevedo, C, Garcia, J, Lopes, M, Maia, B, Maselli, P, Melo, R, Mendes, W, Neves, M, Ney, J, Piras, C, Applewhaite, C, Carr, A, Chow, L, Duttchen, K, Foglia, J, Greene, M, Hinther, A, Houston, K, McCormick, TJ, Mikhayel, J, Montasser, S, Ragan, A, Suen, A, Woolsey, A, Yu, HC, Funk, D, Kowalski, S, Legaspi, R, McDonald, H, Siddiqui, F, Pridham, J, Rowe, B, Sampson, S, Thiessen, B, Zbitnew, G, Bernard, A, George, R, Jones, P, Moor, R, Siddiqui, N, Wolfer, A, Tran, D, Winch, D, Dobson, G, McCormick, T, Montasser, O, Hall, R, Baghirzada, L, Curley, G, Dai, SY, Hare, G, Lee, E, Shastri, U, Tsui, A, Yagnik, A, Alvares, D, Choi, S, Dwyer, H, Flores, K, McCartney, C, Somascanthan, P, Beattie, S, Carroll, J, Pazmino-Canizares, J, Wijeysundera, D, Ami, N, Chan, V, Perlas, A, Argue, R, Huang, Y, Lavis, K, Mayson, K, Cao, Y, Gao, H, Hu, T, Lv, J, Yang, J, Yang, Y, Zhong, Y, Zhou, J, Zou, X, He, M, Li, X, Luo, D, Wang, H, Yu, T, Chen, L, Wang, L, Cai, Y, Cao, Z, Li, Y, Lian, J, Sun, H, Wang, S, Wang, Z, Wang, K, Zhu, Y, Du, X, Fan, H, Fu, Y, Huang, L, Hwan, H, Luo, H, Qu, P-S, Tao, F, Wang, G, Zhang, Y, Zhang, X, Chen, C, Wang, W, Liu, Z, Fan, L, Tang, J, Chen, Y, Han, Y, Huang, C, Liang, G, Shen, J, Wang, J, Yang, Q, Zhen, J, Zhou, H, Chen, J, Chen, Z, Meng, B, Ye, H, Bi, Y, Cao, J, Guo, F, Lin, H, Liu, Y, Lv, M, Shi, P, Song, X, Sun, C, Sun, Y, Wang, Y, Zhang, M, Chen, R, Hou, J, Leng, Y, Meng, Q-T, Qian, L, Shen, Z-Y, Xia, Z-Y, Xue, R, Zhao, B, Zhou, X-J, Chen, Q, Guo, H, Guo, Y, Qi, Y, Wei, J, Zhang, W, Zheng, L, Bao, Q, Fei, Y, Hu, N, Hu, X, Lei, M, Lv, X, Miao, F, Ouyang, L, Shen, C, Wang, D, Wu, C, Xu, L, Yuan, J, Zhang, L, Zhang, H, Zhao, J, Zhao, C, Zhao, L, Zheng, T, Zhou, D, Zhou, C, Lu, K, Zhao, T, He, C, Chen, H, Chen, S, Cheng, B, He, J, Jin, L, Li, C, Li, H, Pan, Y, Shi, Y, Wen, XH, Wu, S, Xie, G, Zhang, K, Lu, X, Chen, F, Liang, Q, Lin, X, Ling, Y, Liu, G, Tao, J, Yang, L, Cheng, Z, Dai, H, Feng, Y, Hou, B, Gong, H, Hu, CH, Huang, H, Huang, J, Jiang, Z, Li, M, Lin, J, Liu, M, Liu, W, Luo, F, Ma, L, Min, J, Shi, X, Song, Z, Wan, X, Xiong, Y, Yang, S, Zhang, Q, Zhao, W, Zhu, X, Bai, Y, Dai, Q, Geng, W, Han, K, He, X, Ji, B, Jia, D, Jin, S, Li, Q, Liang, D, Luo, S, Lwang, L, Mo, Y, Qi, X, Qian, M, Qin, J, Ren, Y, Xie, J, Yan, Y, Yao, Y, Zhuang, X, Ai, Y, Du, F, He, L, Li, Z, Li, L, Meng, S, Yuan, Y, Zhang, E, Zhang, J, Zhao, S, Ji, Z, Pei, L, Dong, B, Li, J, Miao, Z, Mu, H, Qin, C, Su, L, Wen, Z, Xie, K, Yu, Y, Yuan, F, Xiao, W, Zhu, Z, Fu, K, Hu, R, Huang, S, Liang, Y, Yu, S, Guo, Z, Jing, Y, Tang, N, Wu, J, Yuan, D, Zhang, R, Zhao, X, Bai, H-P, Liu, C-X, Liu, F-F, Ren, W, Wang, X-L, Xu, G-J, Li, B, Ou, Y, Tang, Y, Yao, S, Zhang, S, Kong, C-C, Liu, B, Wang, T, Lu, B, Xia, Y, Cai, F, Chen, P, Hu, S, Xu, Q, Hu, L, Jing, L, Liu, Q, Peng, ZD, Qiu, X, Ren, Q, Tong, Y, Wen, Y, Wu, Q, Xia, J, Xiong, X, Xu, S, Yang, T, Yin, N, Zeng, Q, Zhang, B, Zheng, K, Cang, J, Fan, Y, Fu, S, Ge, X, Guo, B, Huang, W, Jiang, L, Jiang, X, Shan, Q, Wang, F, Christiansen, IC, Granum, SN, Rasmussen, BS, Daugaard, M, Gambhir, R, Brandsborg, B, Steingrimsdottir, GE, Jensen-Gadegaard, P, Olsen, KS, Siegel, H, Eskildsen, KZ, Gatke, MR, Wibrandt, I, Heintzelmann, SB, Lange, KHW, Lundsgaard, RS, Amstrup-Hansen, L, Hovendal, C, Larsen, M, Lenstrup, M, Kobborg, T, Larsen, JR, Pedersen, AB, Smith, SH, Oestervig, RM, Rasmussen, L, Afshari, A, Andersen, C, Ekelund, K, Secher, EL, Beloeil, H, Lasocki, S, Venara, A, Biais, M, Ouattara, A, Sineus, M, Molliex, S, Legouge, ML, Wallet, F, Tesniere, A, Gaudin, C, Lehur, P, Forsans, E, de Rudnicki, S, Maudet, VS, Mutter, D, Sojod, G, Ouaissi, M, Regimbeau, J-M, Futier, E, Desbordes, J, Comptaer, N, el Manser, D, Ethgen, S, Lebuffe, G, Auer, P, Haertl, C, Deja, M, Legashov, K, Sonnemann, S, Wiegand-Loehnert, C, Falk, E, Habicher, M, Angermair, S, Laetsch, B, Schmidt, K, Von Heymann, C, Ramminger, A, Jelschen, F, Pabel, S, Weyland, A, Czeslick, E, Gille, J, Malcharek, M, Sablotzki, A, Lueke, K, Wetzel, P, Weimann, J, Lenhart, F-P, Reichle, F, Schirmer, F, Hueppe, M, Klotz, K, Nau, C, Schoen, J, Mencke, T, Wasmund, C, Bankewitz, C, Baumgarten, G, Fleischer, A, Guttenthaler, V, Hack, Y, Kirchgaessner, K, Maenner, O, Schurig-Urbaniak, M, Struck, R, van Zyl, R, Wittmann, M, Goebel, U, Harris, S, Veit, S, Andreadaki, E, Souri, F, Katsiadramis, I, Skoufi, A, Vasileiou, M, Aimoniotou-Georgiou, E, Katsourakis, A, Veroniki, F, Vlachogianni, G, Petra, K, Chlorou, D, Oloktsidou, E, Ourailoglou, V, Papapostolou, K, Tsaousi, G, Daikou, P, Dedemadi, G, Kalaitzopoulos, I, Loumpias, C, 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J, Al 'Amri, K, Aladin, H, Arshad, MA, Barraclough, J, Bentley, C, Bergin, C, Carrera, R, Clarkson, A, Collins, M, Denham, S, Griffiths, E, Ip, P, Jeyanthan, S, Joory, K, Kaur, S, Marriott, P, Mitchell, N, Nagaiah, S, Nilsson, A, Parekh, N, Pope, M, Seager, J, Serag, H, Tameem, A, Thomas, A, Thunder, J, Torrance, A, Vohra, R, whitehouse, A, Wong, T, Blunt, M, Wong, K, Giles, J, Reed, I, Weller, D, Bell, G, Birch, J, Damant, R, Maiden, J, Mewies, C, Prince, C, Radford, J, Reynolds, T, Balain, B, Banerjee, R, Barnett, A, Burston, B, Edwards, J, Evans, C, Ford, D, Gallacher, P, Hill, S, Jaffray, D, Karlakki, S, Kennedy, J, Kiely, N, Lewthwaite, S, Marquis, C, Ockendon, M, Phillips, S, Pickard, S, Richardson, J, Roach, R, Smith, T, Spencer-Jones, R, Steele, N, Steen, J, Van Liefland, M, White, S, Faulds, M, Harris, M, Nicol, S, Pearson, SA, Chukkambotla, S, Andrew, A, Attrill, E, Campbell, G, Datson, A, Fouracres, A, Graterol, J, Graves, L, Hong, B, Ishimaru, A, Karthikeyan, A, King, H, Lawson, T, Lee, G, Lyons, S, Hall, AM, Mathoulin, S, Mcintyre, E, Mclaughlin, D, Mulcahy, K, Paddle, J, Robbins, J, Sung, W, Tayo, A, Trembath, L, Venugopal, S, Wigmore, G, Boereboom, C, Downes, C, Humphries, R, Melbourne, S, Tou, S, Ullah, S, Batchelor, N, Boxall, L, Broomby, R, Deen, T, Hellewell, A, Helliwell, L, Hutchings, M, Hutchins, D, Keenan, S, Mackie, D, Potter, A, Smith, F, Stone, L, Thorpe, K, Wassall, R, Woodgate, A, Baillie, S, Campbell, T, James, S, King, C, de Araujo, DM, Martin, D, Morkane, C, Neely, J, Rajendram, R, Burton, M, James, K, Keevil, E, Minik, O, Morgan, J, Musgrave, A, Rajanna, H, Roberts, T, Szakmany, T, Adamson, M, Jumbe, S, Kendall, J, Muthuswamy, MB, Cruikshanks, A, Wrench, I, Zeidan, L, Ardern, D, Harris, B, Hellstrom, J, Martin, J, Thomas, R, Varsani, N, Brown, CW, Docherty, P, Gillies, M, McGregor, E, Usher, H, Craig, J, Bodger, P, Creary, T, Everingham, K, Fowler, A, Hewson, R, Ijuo, E, Januszewska, M, Jones, T, Kantsedikas, I, Lahiri, S, McLean, AL, Niebrzegowska, E, Phull, M, Wickboldt, N, Baldwin, J, Doyle, D, Mcmullan, S, Oladapo, M, Owen, T, Williams, A, Gregory, P, Husain, T, Kirk-Bayley, J, Mathers, E, Montague, L, Harper, M, Jack, J, Ridley, C, Avis, J, Cook, T, Dali-Kemmery, L, Kerslake, I, Lambourne, V, Pearson, A, Boyd, C, Callaghan, M, Lawson, C, McCrossan, R, Nesbitt, V, O'connor, L, Sinclair, R, Farid, N, Morgese, C, Bhatia, K, Karmarkar, S, Ahmed, J, Branagan, G, Hutton, M, Swain, A, Brookes, J, Cornell, J, Dolan, R, Hulme, J, van Vuuren, AJ, Jowitt, T, Kalashetty, G, Lloyd, F, Patel, K, Sherwood, N, Brown, L, Chandler, B, Deighton, K, Emma, T, Haunch, K, Cheeseman, M, Dent, K, Gray, C, Hood, M, Jones, D, Juj, J, Rao, R, Walker, T, Al Anizi, M, Cheah, C, Cheing, Y, Coutinho, F, Gondo, P, Hadebe, B, Hove, MO, khader, A, Krishnachetty, B, Rhodes, K, Sokhi, J, Baker, K-A, Bertram, W, Looseley, A, Mouton, R, Hanna, G, Arnold, G, Arya, S, Balfoussia, D, Baxter, L, Harris, J, Jones, C, Knaggs, A, Markar, S, Perera, A, Scott, A, Shida, A, Sirha, R, Wright, S, Frost, V, Andrews, E, Arrandale, L, Barrett, S, Cifra, E, Cooper, M, Dragnea, D, Elna, C, Maclean, J, Meier, S, Milliken, D, Munns, C, Ratanshi, N, Ramessur, S, Salvana, A, Watson, A, Ali, H, Critchley, R, Endersby, S, Hicks, C, Liddle, A, Pass, M, Ritchie, C, Thomas, C, Too, L, Welsh, S, Gill, T, Johnson, J, Reed, J, Davis, E, Papadopoullos, S, Attwood, C, Biffen, A, Boulton, K, Gray, S, Hay, D, Mills, S, Montgomery, J, Riddell, R, Simpson, J, Bhardwaj, N, Paul, E, Uwubamwen, N, Alexander, M, Arrich, J, Arumugam, S, Blackwood, D, Boggiano, V, Chan, YL, Chatterjee, D, Chhabra, A, Christian, R, Costelloe, H, Matthewman, MC, Dalton, E, Darko, J, Davari, M, Dave, T, Deacon, M, Deepak, S, Edmond, H, Ellis, J, El-Sayed, A, Eneje, P, English, R, Ewe, R, Foers, W, Franklin, J, Gallego, L, Garrett, E, Goldberg, O, Goss, H, Greaves, R, Harris, R, Hennings, C, Jones, E, Kamali, N, Kokkinos, N, Lewis, C, Lignos, L, Malgapo, EV, Malik, R, Milne, A, 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Campbell, M, Chan, P, Jemmett, K, Raj, A, Naik, A, Oshowo, A, Ramamoorthy, R, Shah, N, Sylvan, A, Blyth, K, Burtenshaw, A, Freeman, D, Johnson, E, Lo, P, Martin, T, Plunkett, E, Wollaston, J, Allison, J, Carroll, C, Craw, N, Craw, S, Pitt-Kerby, T, Rowland-Axe, R, Spurdle, K, McDonald, A, Simon, D, Sinha, V, Banner-Goodspeed, V, Boone, M, Campbell, K, Lu, F, Scannell, J, Sobol, J, Balajonda, N, Clemmons, K, Conde, C, Elgasim, M, Funk, B, Hopkins, T, Olaleye, O, Omer, O, Pender, M, Porto, A, Waweru, P, Yeh, E, Bodansky, D, Evans, A, Kleopoulos, S, Maril, R, Mathney, E, Sanchez, A, Tinuoye, E, Bateman, B, Eng, K, Jiang, N, Ladha, K, Needleman, J, Chen, L-L, Lane, R, Robinowitz, D, Ghushe, N, Irshad, M, O'Connor, J, Patel, S, Takemoto, S, Wallace, A, Mazzeffi, M, Rock, P, Wallace, K, Chua, P, Fleisher, L, Mattera, M, Sharar, R, Thilen, S, Treggiari, M, Morgan, A, Sofjan, I, Subramaniam, K, Avidan, M, Maybrier, H, Muench, M, Wildes, T, ISOS, ISOS, Int Surgical Outcomes Study ISOS, Anesthesiology, ACS - Diabetes & metabolism, ACS - Microcirculation, ACS - Amsterdam Cardiovascular Sciences, APH - Quality of Care, ACS - Heart failure & arrhythmias, and International Surgical Outcomes Study (ISOS) group
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Male ,IMPACT ,Cancer ,Complication rate ,Mortality ,Oesophagectomy ,Postoperative care ,Upper gastrointestinal surgery ,SURGICAL COMPLICATIONS ,0302 clinical medicine ,Postoperative Complications ,Risk Factors ,Outcome Assessment, Health Care ,030212 general & internal medicine ,Hospital Mortality ,Prospective Studies ,ESOPHAGOGASTRIC CANCER ,Prospective cohort study ,Digestive System Surgical Procedures ,RISK ,Perioperative medicine ,General Medicine ,Middle Aged ,Oncology ,Length of Stay/statistics & numerical data ,Elective Surgical Procedures ,MORTALITY FOLLOWING ESOPHAGECTOMY ,030220 oncology & carcinogenesis ,Female ,Elective Surgical Procedure ,Cohort study ,medicine.medical_specialty ,ENHANCED RECOVERY ,PERIOPERATIVE MEDICINE ,Postoperative Complications/mortality ,NO ,03 medical and health sciences ,Outcome Assessment (Health Care) ,MORBIDITY ,medicine ,Humans ,Digestive System Surgical Procedures/mortality ,business.industry ,LONG-TERM SURVIVAL ,Odds ratio ,Length of Stay ,CARE ,medicine.disease ,Confidence interval ,Surgery ,Human medicine ,Complication ,business - Abstract
Aims: Previous research suggests that patients undergoing upper gastrointestinal surgery are at high risk of poor postoperative outcomes. The aim of our study was to describe patient outcomes after elective upper gastrointestinal surgery at a global level.Methods: Prospective analysis of data collected during an international seven-day cohort study of 474 hospitals in 27 countries. Patients undergoing elective upper gastrointestinal. surgery were recruited. Outcome measures were in-hospital complications and mortality at 30-days. Results are presented as n(%) and odds ratios with 95% confidence intervals.Results: 2139 patients were included, of whom 498 (23.2%) developed one or more postoperative complications, with 30 deaths (1.4%). Patients with complications had longer median hospital stay 11 (6-18) days vs. 5 (2-10) days. Infectious complications were most frequent, affecting 368 (17.2%) patients. 328 (15.3%) patients were admitted to critical care postoperatively, of whom 161 (49.1%) developed a complication with 14 deaths (4.3%). In a multivariable logistic regression model we identified age (OR 1.02 [1.01-1.03]), American Society of Anesthesiologists physical status III (OR 2.12 [1.44-3.16]) and IV (OR 3.23 [1.72-6.09]), surgery for cancer (OR 1.63 [1.27-2.11]), open procedure (OR 1.40 [1.10-1.78]), intermediate surgery (OR 1.75 [1.12-2.81]) and major surgery (OR 2.65 [1.72-4.23]) as independent risk factors for postoperative complications. Patients undergoing major surgery for upper gastrointestinal cancer experienced twice the rate of complications compared to those undergoing other procedures (224/578 patients [38.8%] versus 274/1561 patients [17.6%]).Conclusions: Complications and death are common after upper gastrointestinal surgery. Patients undergoing major surgery for cancer are at greatest risk. (C) 2017 Elsevier Ltd, BASO similar to The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.
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- 2017
46. Antiplatelet therapy with aspirin, clopidogrel, and dipyridamole versus clopidogrel alone or aspirin and dipyridamole in patients with acute cerebral ischaemia (TARDIS): a randomised, open-label, phase 3 superiority trial
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Bath, Philip M, primary, Woodhouse, Lisa J, additional, Appleton, Jason P, additional, Beridze, Maia, additional, Christensen, Hanne, additional, Dineen, Robert A, additional, Duley, Lelia, additional, England, Timothy J, additional, Flaherty, Katie, additional, Havard, Diane, additional, Heptinstall, Stan, additional, James, Marilyn, additional, Krishnan, Kailash, additional, Markus, Hugh S, additional, Montgomery, Alan A, additional, Pocock, Stuart J, additional, Randall, Marc, additional, Ranta, Annemarei, additional, Robinson, Thompson G, additional, Scutt, Polly, additional, Venables, Graham S, additional, Sprigg, Nikola, additional, Christensen, L M, additional, Bentsen, L, additional, Krarup Hansen, C, additional, Thomsen, T T, additional, Kruuse, C, additional, Jensen, H H, additional, Hansen, S S, additional, Petrovic, V, additional, Beridze, N, additional, Kakabadze, N, additional, Kherkheulidze, T, additional, Kakabadze, D, additional, Toidze, I, additional, Lobjanidze, N, additional, Akiashvili, N, additional, Tevdoradze, A, additional, Khizanishvili, N, additional, Tsanava, T, additional, Taylor, R, additional, Iniesta, I, additional, Kok, J, additional, Duignan, J, additional, Funnell, M, additional, Cariga, P, additional, Rodriguez, M, additional, Watson, I J, additional, Tennant, S, additional, Macleod, M, additional, Furnace, J, additional, Gow, H, additional, Irvine, J, additional, Joyson, A, additional, Nelson, S, additional, Taylor, V, additional, Smith, M, additional, Bellfield, R, additional, Hairsine, B, additional, Davies, R, additional, Dodd, A, additional, Corrigan, J, additional, Doherty, M, additional, Ahmed, A, additional, Denniss, C, additional, Johnson-Holland, S, additional, Kay, K A, additional, Palau, R Icart, additional, Auld, G, additional, Daboo, P, additional, Erande, R, additional, Grimwood, G, additional, Hove, D, additional, Howaniec, L, additional, Redjep, O, additional, Rangasamay, R, additional, Butt, G, additional, 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additional, Hayward, D, additional, Jenkins, K, additional, Keeling, E, additional, Rowland-Axe, R, additional, Vickers, C, additional, Wood, D, additional, Lehman, A, additional, Patel, M, additional, Russell, H, additional, Rehman, H, additional, Forrest, D, additional, and Farren, P, additional
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- 2018
- Full Text
- View/download PDF
47. Differences in appetite-related hormone concentrations between older and younger adults: A systematic review and meta-analysis
- Author
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Johnson, K.O., primary, Shannon, O.M., additional, Matu, J., additional, Holliday, A., additional, Ispoglou, T., additional, and Deighton, K., additional
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- 2018
- Full Text
- View/download PDF
48. How well do activity monitors estimate energy expenditure? A systematic review and meta-analysis of the validity of current technologies
- Author
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O'Driscoll, R., primary, Turicchi, J., additional, Scott, S., additional, Beaulieu, K., additional, Matu, J., additional, Deighton, K., additional, Finlayson, G., additional, and Stubbs, R.J., additional
- Published
- 2018
- Full Text
- View/download PDF
49. Novel essential amino acid supplements enriched with L-leucine facilitate increased protein and energy intakes in older women: a randomised controlled trial
- Author
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Ispoglou, T, Deighton, K, King, R, White, H, Lees, M, Ispoglou, T, Deighton, K, King, R, White, H, and Lees, M
- Abstract
Background: Inadequate protein intake (PI), containing a sub-optimal source of essential amino acids (EAAs), and reduced appetite are contributing factors to age-related sarcopenia. The satiating effects of dietary protein per se may negatively affect energy intake (EI), thus there is a need to explore alternative strategies to facilitate PI without compromising appetite and subsequent EI. Methods: Older women completed two experiments (EXP1 and EXP2) where they consumed either a Bar (565 kJ), a Gel (477 kJ), both rich in EAAs (7.5 g, 40% L-leucine), or nothing (Control). In EXP1, participants (n=10, 68±5 years, mean±SD) consumed Bar, Gel or Control with appetite sensations and appetite-related hormonal responses monitored for one hour, followed by consumption of an ad libitum breakfast (ALB). In EXP2, participants (n=11, 69±5 years) ingested Bar, Gel or Control alongside an ALB. Results: In EXP1, EI at ALB was not different (P=0.674) between conditions (1179±566, 1254±511, 1206±550 kJ for the Control, Bar, and Gel respectively). However, total EI was significantly higher in the Bar and Gel compared to the Control after accounting for the energy content of the supplements (P<0.0005). Analysis revealed significantly higher appetite Area under the Curve (AUC) (P<0.007), a tendency for higher acylated ghrelin AUC (P=0.087), and significantly lower pancreatic polypeptide AUC (P=0.02) in the Control compared with the Bar and Gel. In EXP2, EI at ALB was significantly higher (P=0.028) in the Control (1282±513 kJ) compared to the Bar (1026±565 kJ) and Gel (1064±495 kJ). However, total EI was significantly higher in the Bar and Gel after accounting for the energy content of the supplements (P<0.007). Conclusions: Supplementation with either the Bar or Gel increased total energy intake whether consumed one hour before or during breakfast. This may represent an effective nutritional means for addressing protein and total energy deficiencies in older women.
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- 2017
50. Snap-N-Send: A valid and reliable method for assessing the energy intake of elite adolescent athletes.
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Costello, NB, Deighton, K, Dyson, J, McKenna, J, Jones, B, Costello, NB, Deighton, K, Dyson, J, McKenna, J, and Jones, B
- Abstract
To ensure that elite adolescent athletes meet their unique training, growth and maturation demands, it is imperative to have access to valid measures of energy intake. Contemporary methods demand close attention-to-detail, meaning that athletes often do not fully adhere to real-time protocols. This study represents the first investigation of a real-time dietary assessment designed using a comprehensive behaviour change framework (COM-B). In a crossover design, 12 elite adolescent male rugby players recorded their energy intake via an estimated food diary (est-FD) and photography-based mobile assessment ('Snap-n-Send'), combined with a 24-h dietary recall interview. Two 4-day assessment periods were divided into three separate recording environments: 96 h free-living and researcher-observed; 72 h free-living and 10 h researcher-observed. Assessment periods were one month apart. All foods and beverages were provided and weighed by the research team to quantify actual intakes. 'Snap-n-Send' reported a small mean bias for under-reporting across 96 h (-0.75 MJ day(-1); 95% confidence interval [CI] for bias = -5.7% to -2.2%, p < .001), 72 h (-0.76 MJ day(-1); 95% CI for bias = -5.6% to -2.1%, p = .004) and 10 h (-0.72 MJ day(-1); 95% CI for bias = -8.1% to -0.1%; p = .067) environments. The est-FD reported a moderate mean bias for under-reporting across 96 h (-2.89 MJ day(-1); 95% CI for bias = -17.9% to -10.2%; p < .001), 72 h (-2.88 MJ day(-1); 95% CI for bias = -17.9% to -10.1%; p < .001) and 10 h (-2.52 MJ day(-1);-26.1% to -5.3%; p = .023) environments. Results evidence the ability of 'Snap-n-Send' to accurately assess the diet of elite adolescent athletes, signalling the exciting promise of this comprehensive and theoretical behavioural approach within valid dietary assessment.
- Published
- 2017
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