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11 results on '"Dehghan, Hamideh"'

8. Multifunctional Self-Assembled Peptide Hydrogels for Biomedical Applications

Author

Sedighi, Mahsa, primary, Shrestha, Neha, additional, Mahmoudi, Zahra, additional, Khademi, Zahra, additional, Ghasempour, Alireza, additional, Dehghan, Hamideh, additional, Talebi, Seyedeh Fahimeh, additional, Toolabi, Maryam, additional, Préat, Véronique, additional, Chen, Bozhi, additional, Guo, Xindong, additional, and Shahbazi, Mohammad-Ali, additional

Published
2023
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11. An update on the therapeutic role of RNAi in NAFLD/NASH.

Author

Dehghan H, Ghasempour A, Sabeti Akbar-Abad M, Khademi Z, Sedighi M, Jamialahmadi T, and Sahebkar A

Subjects
Humans, RNA Interference, Liver Cirrhosis, Oligonucleotides therapeutic use, Non-alcoholic Fatty Liver Disease therapy, Non-alcoholic Fatty Liver Disease drug therapy
Abstract

Unhealthy lifestyles have given rise to a growing epidemic of metabolic liver diseases, including nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). NAFLD often occurs as a consequence of obesity, and currently, there is no FDA-approved drug for its treatment. However, therapeutic oligonucleotides, such as RNA interference (RNAi), represent a promising class of pharmacotherapy that can target previously untreatable conditions. The potential significance of RNAi in maintaining physiological homeostasis, understanding pathogenesis, and improving metabolic liver diseases, including NAFLD, is discussed in this article. We explore why NAFLD/NASH is an ideal target for therapeutic oligonucleotides and provide insights into the delivery platforms of RNAi and its therapeutic role in addressing NAFLD/NASH., (Copyright © 2024. Published by Elsevier Inc.)

Published
2024
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