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28 results on '"Dehaini, Hassan"'

10. A Systematic Review and Meta-analysis of Racial Enrollment in Peripheral Artery Disease Randomized Controlled Trials in North America

Author

Kirksey, Levester, primary, Dehaini, Hassan, additional, Sorour, Ahmed A., additional, Alnahhal, Khaled I., additional, Walker, Claudia, additional, Sharew, Betemariam, additional, Baffoe-Bonnie, Helena, additional, Rowse, Jarrad W., additional, Quatromoni, Jon, additional, Caputo, Francis J., additional, and Lyden, Sean P., additional

Published
2023
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14. Supplemental Material - Predictors for Distal Revascularization Following Femoral Endarterectomy in Chronic Limb-Threatening Ischemia Patients

Author

Alnahhal, Khaled I., Dehaini, Hassan, Sorour, Ahmed A, Vyas, Priyam, Chumakova, Maryana, Bena, James, and Kirksey, Lee

Subjects
FOS: Clinical medicine, Cardiology, 110323 Surgery
Abstract

Supplemental Material for Predictors for Distal Revascularization Following Femoral Endarterectomy in Chronic Limb-Threatening Ischemia Patients by Khaled I. Alnahhal, Hassan Dehaini, Ahmed Sorour, Priyam Vyas, Maryana Chumakova, James Bena, and Lee Kirksey in Vascular and Endovascular Surgery

Published
2023
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22. Medicine in Unplanned Mass Gatherings: A Qualitative Study of Health-Care Providers' Response and Recommendations to Beirut's Protests.

Author

Yassine, Farah, Bou Karroum, Samer, Amine, Reem, Chammas, Majid, Dehaini, Hassan, El-Khoury, Habib, Haddad, Andrea, Khalifeh, Joanna, Maaliki, Maya, and Ghandour, Lilian

Subjects
MEDICAL care, ORGANIZATIONAL structure, SEMI-structured interviews
Abstract

Objective: This study aims at exploring the dynamics of health-care provision during recent unplanned public mass gatherings in Beirut, and how the health-care system adapts to mass movements in protests. Methods: A qualitative study was conducted using semi-structured interviews with 12 health-care providers who volunteered at medical tents set during protests in Beirut, Lebanon. Responses were transcribed and coded. Results: Three themes were noted: preparedness and logistics, encountered cases, and participants' proposed recommendations. In terms of preparedness and logistics, participants lacked knowledge of field medicine protocols and an organizational structure. They faced difficulties in securing equipment and advertising their services. Most encountered cases were physical injuries rather than mental health problems. The participants proposed both short-term recommendations, including advice on how to boost care provided, and long-term recommendations on structuring the health-care system to be better prepared. Conclusions: On-site health-care provision during unplanned mass gatherings is a vital need. We recommend forming a task force of health-care workers from various fields led by the Ministry of Public Health in every respective country to plan protocols, train personnel, and secure resources beforehand. [ABSTRACT FROM AUTHOR]

Published
2022
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25. MicroRNAs as Potential Pharmaco-targets in Ischemia-Reperfusion Injury Compounded by Diabetes

Author

Dehaini, Hassan, Awada, Hussein, El-Yazbi, Ahmed, Zouein, Fouad A., Issa, Khodr, Eid, Assaad A., Ibrahim, Maryam, Badran, Adnan, Baydoun, Elias, Pintus, Gianfranco, and Eid, Ali H.

Subjects
reactive oxygen species, diabetes, microRNA, ischemia-reperfusion injury, apoptosis, pharmaco-targets, Review, Models, Biological, MicroRNAs, lcsh:Biology (General), Reperfusion Injury, Diabetes Mellitus, Animals, Humans, Molecular Targeted Therapy, lcsh:QH301-705.5
Abstract

Background: Ischemia-Reperfusion (I/R) injury is the tissue damage that results from re-oxygenation of ischemic tissues. There are many players that contribute to I/R injury. One of these factors is the family of microRNAs (miRNAs), which are currently being heavily studied. This review aims to critically summarize the latest papers that attributed roles of certain miRNAs in I/R injury, particularly in diabetic conditions and dissect their potential as novel pharmacologic targets in the treatment and management of diabetes. Methods: PubMed was searched for publications containing microRNA and I/R, in the absence or presence of diabetes. All papers that provided sufficient evidence linking miRNA with I/R, especially in the context of diabetes, were selected. Several miRNAs are found to be either pro-apoptotic, as in the case of miR-34a, miR-144, miR-155, and miR-200, or anti-apoptotic, as in the case of miR-210, miR-21, and miR-146a. Here, we further dissect the evidence that shows diverse cell-context dependent effects of these miRNAs, particularly in cardiomyocytes, endothelial, or leukocytes. We also provide insight into cases where the possibility of having two miRNAs working together to intensify a given response is noted. Conclusions: This review arrives at the conclusion that the utilization of miRNAs as translational agents or pharmaco-targets in treating I/R injury in diabetic patients is promising and becoming increasingly clearer.

Published
2019

27. 7-O-Methylpunctatin, a Novel Homoisoflavonoid, Inhibits Phenotypic Switch of Human Arteriolar Smooth Muscle Cells.

Author

Fardoun, Manal, Iratni, Rabah, Dehaini, Hassan, Eid, Assaad, Ghaddar, Tarek, El-Elimat, Tamam, Alali, Feras, Badran, Adnan, Eid, Ali H., and Baydoun, Elias

Subjects
MUSCLE cells, SMOOTH muscle, VASCULAR smooth muscle, HUMAN behavior, CELL proliferation, MONOCYTES
Abstract

Remodeling of arterioles is a pivotal event in the manifestation of many inflammation-based cardio-vasculopathologies, such as hypertension. During these remodeling events, vascular smooth muscle cells (VSMCs) switch from a contractile to a synthetic phenotype. The latter is characterized by increased proliferation, migration, and invasion. Compounds with anti-inflammatory actions have been successful in attenuating this phenotypic switch. While the vast majority of studies investigating phenotypic modulation were undertaken in VSMCs isolated from large vessels, little is known about the effect of such compounds on phenotypic switch in VSMCs of microvessels (microVSMCs). We have recently characterized a novel homoisoflavonoid that we called 7-O-methylpunctatin (MP). In this study, we show that MP decreased FBS-induced cell proliferation, migration, invasion, and adhesion. MP also attenuated adhesion of THP-1 monocytes to microVSMCs, abolished FBS-induced expression of MMP-2, MMP-9, and NF-κB, as well as reduced activation of ERK1/2 and FAK. Furthermore, MP-treated VSMCs showed an increase in early (myocardin, SM-22α, SM-α) and mid-term (calponin and caldesmon) differentiation markers and a decrease in osteopontin, a protein highly expressed in synthetic VSMCs. MP also reduced transcription of cyclin D1, CDK4 but increased protein levels of p21 and p27. Taken together, these results corroborate an anti-inflammatory action of MP on human microVSMCs. Therefore, by inhibiting the synthetic phenotype of microVSMCs, MP may be a promising modulator for inflammation-induced arteriolar pathophysiology. [ABSTRACT FROM AUTHOR]

Published
2019
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