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16 results on '"Degnin, Catherine R."'

1. Safety and Efficacy of Accelerated Hypofractionation and Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma Patients With Varying Degrees of Hepatic Impairment

Author

Nabavizadeh, Nima, Waller, Joseph G., Fain, Robert, III, Chen, Yiyi, Degnin, Catherine R., Elliott, David A., Mullins, Brandon T., Patel, Ishan A., Dyer, Brandon A., Fakhoury, Kareem, Naugler, Willscott E., Farsad, Khashayar, Tanyi, James A., Fuss, Martin, Thomas, Charles R., Jr., and Hung, Arthur Y.

Published
2018
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4. Does a fine line exist between regional and metastatic pelvic lymph nodes in rectal cancer—striking discordance between national guidelines and treatment recommendations by US radiation oncologists

Author

Yahya, Jehan Belal, primary, Herzig, Daniel O., additional, Farrell, Matthew Joseph, additional, Degnin, Catherine R., additional, Chen, Yiyi, additional, Holland, John, additional, Brown, Simon, additional, Jaboin, Jerry, additional, Tsikitis, Vassiliki Liana, additional, Lu, Kim, additional, Thomas Jr, Charles R., additional, and Mitin, Timur, additional

Published
2018
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7. Fibroblast Growth Factor Receptor 3 (FGFR3) Is a Strong Heat Shock Protein 90 (Hsp90) Client: IMPLICATIONS FOR THERAPEUTIC MANIPULATION*

Author

Laederich, Melanie B., Degnin, Catherine R., Lunstrum, Gregory P., Holden, Paul, and Horton, William A.

Subjects
musculoskeletal diseases, congenital, hereditary, and neonatal diseases and abnormalities, Chaperonins, Lactams, Macrocyclic, Ubiquitination, Molecular Bases of Disease, Cell Cycle Proteins, musculoskeletal system, Achondroplasia, stomatognathic diseases, Mice, COS Cells, Chlorocebus aethiops, Enzyme Stability, polycyclic compounds, Benzoquinones, Animals, Humans, Receptor, Fibroblast Growth Factor, Type 3, HSP90 Heat-Shock Proteins, Molecular Chaperones
Abstract

Fibroblast growth factor receptor 3 (FGFR3) is a key regulator of growth and differentiation, whose aberrant activation causes a number of genetic diseases including achondroplasia and cancer. Hsp90 is a specialized molecular chaperone involved in stabilizing a select set of proteins termed clients. Here, we delineate the relationship of Hsp90 and co-chaperone Cdc37 with FGFR3 and the FGFR family. FGFR3 strongly associates with these chaperone complexes and depends on them for stability and function. Inhibition of Hsp90 function using the geldanamycin analog 17-AAG induces the ubiquitination and degradation of FGFR3 and reduces the signaling capacity of FGFR3. Other FGFRs weakly interact with these chaperones and are differentially influenced by Hsp90 inhibition. The Hsp90-related ubiquitin ligase CHIP is able to interact and destabilize FGFR3. Our results establish FGFR3 as a strong Hsp90 client and suggest that modulating Hsp90 chaperone complexes may beneficially influence the stability and function of FGFR3 in disease.

Published
2011

8. Novel Type II Collagen Reporter Mice: New Tool for Assessing Collagen 2 alpha 1 Expression In Vivo and In Vitro

Author

Tryfonidou, Marianna A., Lunstrum, Gregory P., Hendriks, Kristyanne, Riemers, Frank M., Wubbolts, Richard, Hazewinkel, H. A. W., Degnin, Catherine R., Horton, William A., Chirurgie, CS_Locomotion, Celbiologie, IOV CCB, and DOO algemeen

Subjects
Col2 alpha 1, Ordered by external client, Growth plate, Gfp, Chondrocyte, Reporter mice
Abstract

We report the generation of a new mouse strain harboring a Col2-pd2EGFP reporter transgene; pd2EGFP has a much shorter half-life than EGFP, making it a near real-time reporter for Col2 alpha 1 expression in vivo and in vitro. In the post-natal growth plate, pd2EGFP fluorescence was expressed in almost all proliferative chondrocytes and in some hypertrophic chondrocytes based on localization with type X collagen. In articular cartilage, pd2EGFP fluorescence diminished over time, nicely illustrating the decrease of type II collagen synthesis in articular chondrocytes during growth. Monolayers of FACS-sorted chondrocytes from P1-2 mice showed faster loss of pd2EGFP compared to EGFP, reflecting rapid chondrocyte de-differentiation. High-density culture of FACS-pd2EGFP- growth plate chondrocytes revealed the typical temporal expression pattern in which type II collagen preceded type X collagen matrix deposition. The Col2-pd2EGFP reporter mouse will be a valuable tool for studies of growth plate chondrocyte biology. Developmental Dynamics 240:663-673, 2011. (C) 2011 Wiley-Liss, Inc.

Published
2011

10. Novel Type II Collagen Reporter Mice: New Tool for Assessing Collagen 2 alpha 1 Expression In Vivo and In Vitro

Author

Chirurgie, CS_Locomotion, Celbiologie, IOV CCB, DOO algemeen, Tryfonidou, Marianna A., Lunstrum, Gregory P., Hendriks, Kristyanne, Riemers, Frank M., Wubbolts, Richard, Hazewinkel, H. A. W., Degnin, Catherine R., Horton, William A., Chirurgie, CS_Locomotion, Celbiologie, IOV CCB, DOO algemeen, Tryfonidou, Marianna A., Lunstrum, Gregory P., Hendriks, Kristyanne, Riemers, Frank M., Wubbolts, Richard, Hazewinkel, H. A. W., Degnin, Catherine R., and Horton, William A.

Published
2011

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