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1. Rationale and design of the HeartLogic French Cohort Study: Remote monitoring of heart failure patients implanted with a cardiac defibrillator enabled with the HeartLogic algorithm

Author

Garcia, R., primary, Mansourati, J., additional, Gras, D., additional, Probst, V., additional, Khattar, P., additional, Himbert, C., additional, Gandjbakhch, E., additional, Saulnier, P.-J., additional, Constantin, V., additional, Lequeux, B., additional, Gueffet, J.-P., additional, Combes, S., additional, Minois, D., additional, Gras, M., additional, Bisson, A., additional, Pierre, B., additional, Defaye, P., additional, Marijon, E., additional, Boveda, S., additional, and Degand, B., additional

Published
2023
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3. Evaluation of a multisensory algorithm to prevent acute decompensation of heart failure in patients implanted with a cardioverter defibrillator: rationale and design

Author

Garcia, R, primary, Mansourati, J, additional, Gras, D, additional, Probst, V, additional, Khattar, P, additional, Himbert, C, additional, Saulnier, P J, additional, Constantin-Jacquot, V, additional, Gueffet, J P, additional, Minois, D, additional, Pierre, B, additional, Defaye, P, additional, Marijon, E, additional, Boveda, S, additional, and Degand, B, additional

Published
2022
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4. Endocardial ablation of ventricular tachycardia ablation in arrhythmogenic right ventricular cardiomyopathy aiming epicardial late potential abolition

Author

Waintraub, X, primary, Sauve, R, additional, Vedrenne, G, additional, Amet, D, additional, Gras, M, additional, Degand, B, additional, Moini, C, additional, Duthoit, G, additional, Laredo, M, additional, Badenco, N, additional, Lesaffre, F, additional, Lepillier, A, additional, Hidden Lucet, F, additional, Hermida, A, additional, and Gandjbakhch, E, additional

Published
2022
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10. Cardiac resynchronisation therapy in patients with cardiac amyloidosis: A multicentre retrospective study

Author

Fischer, K., primary, Lellouche, N., additional, Damy, T., additional, Martins, R., additional, Clementy, N., additional, Bisson, A., additional, Lesaffre, F., additional, Espinosa, M., additional, Garcia, R., additional, Degand, B., additional, Serzian, G., additional, Guichard, J., additional, Laurent, G., additional, and Guenancia, C., additional

Published
2021
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16. Poster session 4: Friday 5 December 2014, 08:30-12:30Location: Poster area

Author

Orii M, Tanimoto T, Yokoyama M, Ota S, Kubo T, Hirata K, Tanaka A, Imanishi T, Akasaka T, Michelsen M, Pena A, Mygind N, Hoest N, Prescott E, Abd El Dayem S, Battah A, Abd El Azzez F, Ahmed A, Fattoh A, Ismail R, Andjelkovic K, Kalimanovska Ostric D, Nedeljkovic I, Andjelkovic I, Rashid H, Abuel Enien H, Ibraheem M, Vago H, Toth A, Csecs I, Czimbalmos C, Suhai FI, Kecskes K, Becker D, Simor T, Merkely B, D'ascenzi F, Pelliccia A, Natali B, Cameli M, Lisi M, Focardi M, Corrado D, Bonifazi M, Mondillo S, Zaha V, Kim G, Su K, Zhang J, Mikush N, Ross J, Palmeri M, Young L, Tadic M, Ilic S, Celic V, Jaimes C, Gonzalez Mirelis J, Gallego M, Goirigolzarri J, Pellegrinet M, Poli S, Prati G, Vriz O, Di Bello V, Carerj S, Zito C, Mateescu A, Popescu B, Antonini Canterin F, Chatzistamatiou E, Moustakas G, Memo G, Konstantinidis D, Mpampatzeva Vagena I, Manakos K, Traxanas K, Vergi N, Feretou A, Kallikazaros I, Hewing B, Theres L, Dreger H, Spethmann S, Stangl K, Baumann G, Knebel F, Uejima T, Itatani K, Nakatani S, Lancellotti P, Seo Y, Zamorano J, Ohte N, Takenaka K, Naar J, Mortensen L, Johnson J, Winter R, Shahgaldi K, Manouras A, Braunschweig F, Stahlberg M, Coisne D, Al Arnaout AM, Tchepkou C, Raud Raynier P, Diakov C, Degand B, Christiaens L, Barbier P, Mirea O, Cefalu C, Savioli G, Guglielmo M, Maltagliati A, O'neill L, Walsh K, Hogan J, Manzoor T, Ahern B, Owens P, Sengelov M, Biering Sorensen T, Jorgensen P, Bruun N, Fritz Hansen T, Bech J, Olsen F, Sivertsen J, Jensen J, Marta L, Abecasis J, Reis C, Ribeiras R, Andrade M, Mendes M, D'andrea A, Stanziola A, Di Palma E, Martino M, Lanza M, Betancourt V, Maglione M, Calabro' R, Russo M, Bossone E, Vogt MO, Meierhofer Ch, Rutz T, Fratz S, Ewert P, Roehlig Ch, Kuehn A, Storsten P, Eriksen M, Remme E, Boe E, Smiseth O, Skulstad H, Ereminiene E, Ordiene R, Ivanauskas V, Vaskelyte J, Stoskute N, Kazakauskaite E, Benetis R, Marketou M, Parthenakis F, Kontaraki J, Zacharis E, Maragkoudakis S, Logakis J, Roufas K, Vougia D, Vardas P, Dado E, Knuti G, Djamandi J, Shota E, Sharka I, Saka J, Halmai L, Nemes A, Kardos A, Neubauer S, Kurnicka K, Domienik Karlowicz J, Lichodziejewska B, Goliszek S, Grudzka K, Krupa M, Dzikowska Diduch O, Ciurzynski M, Pruszczyk P, Chung H, Kim J, Yoon Y, Min P, Lee B, Hong B, Rim S, Kwon H, Choi E, Soya O, Kuryata O, Kakihara R, Naruse C, Inayoshi A, El Sebaie M, Frer A, Abdelsamie M, Eldamanhory A, Ciampi Q, Cortigiani L, Simioniuc A, Manicardi C, Villari B, Picano E, Sicari R, Ferferieva V, Deluyker D, Lambrichts I, Rigo J, Bito V, Kuznetsov V, Yaroslavskaya E, Krinochkin D, Pushkarev G, Gorbatenko E, Trzcinski P, Michalski B, Lipiec P, Szymczyk E, Peczek L, Nawrot B, Chrzanowski L, Kasprzak J, Todaro M, Khandheria B, Cusma Piccione M, La Carrubba S, Oreto G, Di Bella G, Gunyeli E, Oliveira Da Silva C, Sahlen A, Spampinato R, Tasca M, Roche E. Silva J, Strotdrees E, Schloma V, Dmitrieva Y, Dobrovie M, Borger M, Mohr F, Einarsen E, Cramariuc D, Lonnebakken M, Boman K, Gohlke Barwolf C, Chambers J, Gerdts E, Calin A, Rosca M, Beladan C, Mirescu Craciun A, Gurzun M, Enache R, Ginghina C, Antova E, Georgievska Ismail Lj, Srbinovska E, Andova V, Peovska I, Davceva J, Otljanska M, Vavulkis M, Tsuruta H, Kohsaka S, Murata M, Yasuda R, Dan M, Yashima F, Inohara T, Maekawa Y, Hayashida K, Fukuda K, Migliore R, Adaniya M, Barranco M, Miramont G, Gonzalez S, Tamagusuku H, Abid L, Ben Kahla S, Charfeddine S, Abid D, Kammoun S, Amano M, Izumi C, Miyake M, Tamura T, Kondo H, Kaitani K, Nakagawa Y, Ghulam Ali S, Fusini L, Tamborini G, Muratori M, Gripari P, Bottari V, Celeste F, Cefalu' C, Alamanni F, Pepi M, Obase K, Mor Avi V, Weinert L, Lang R, Teixeira R, Monteiro R, Garcia J, Ribeiro M, Cardim N, Goncalves L, Miglioranza M, Muraru D, Cavalli G, Addetia K, Cucchini U, Mihaila S, Veronesi F, Badano L, Galian Gay L, Gonzalez Alujas M, Teixido Tura G, Gutierrez Garcia L, Rodriguez Palomares J, Evangelista Masip A, Conte L, Fabiani I, Giannini C, La Carruba S, De Carlo M, Barletta V, Petronio A, Mahmoud H, Al Ghamdi M, Ghabashi A, Salaun E, Zenses A, Evin M, Collart F, Pibarot P, Habib G, Rieu R, Fabregat Andres O, Estornell Erill J, Cubillos Arango A, Bochard Villanueva B, Chacon Hernandez N, Higueras Ortega L, Perez Bosca L, Paya Serrano R, Ridocci Soriano F, Cortijo Gimeno J, Mzoughi K, Zairi I, Jabeur M, Ben Moussa F, Mrabet K, Kamoun S, Fennira S, Ben Chaabene A, Kraiem S, Schnell F, Betancur J, Daudin M, Simon A, Lentz P, Tavard F, Hernandes A, Carre F, Garreau M, Donal E, Abduch M, Vieira M, Antunes M, Mathias W, Mady C, Arteaga E, Alencar A, Tesic M, Djordjevic Dikic A, Beleslin B, Giga V, Trifunovic D, Petrovic O, Jovanovic I, Petrovic M, Stepanovic J, Vujisic Tesic B, Cha J, Kim Kh, Bergler Klein J, Geier C, Maurer G, Gyongyosi M, Cortes Garcia M, Oliva M, Navas M, Orejas M, Rabago R, Martinez M, Briongos S, Romero A, Rey M, Farre J, Ruisanchez Villar C, Ruiz Guerrero L, Rubio Ruiz S, Lerena Saenz P, Gonzalez Vilchez F, Hernandez Hernandez J, Armesto Alonso S, Blanco Alonso R, Martin Duran R, Gonzalez Gay M, Novo G, Marturana I, Bonomo V, Arvigo L, Evola V, Karfakis G, Lo Presti M, Verga S, Novo S, Petroni R, Acitelli A, Bencivenga S, Cicconetti M, Di Mauro M, Petroni A, Romano S, Penco M, Park S, Kim S, Kim M, Shim W, Majstorovic A, Ivanovic B, Driessen MM, Meijboom F, Mertens L, Dragulescu A, Friedberg M, De Stefano F, Santoro C, Buonauro A, Muscariello R, Lo Iudice F, Ierano P, Esposito R, Galderisi M, Sunbul M, Kivrak T, Durmus E, Yildizeli B, Mutlu B, Rodrigues A, Daminello E, Echenique L, Cordovil A, Oliveira W, Monaco Ch, Lira E, Fischer Ch, Morhy S, Mignot A, Jaussaud J, Chevalier L, Lafitte S, Curci V, Alvino F, Ikonomidis I, Pavlidis G, Lambadiari V, Kousathana F, Triantafyllidi H, Varoudi M, Dimitriadis G, Lekakis J, Cho JS, Cho E, Yoon H, Ihm Sh, Lee J, Molnar AA, Kovacs A, Apor A, Tarnoki A, Tarnoki D, Horvath T, Maurovich Horvat P, Jermendy G, Kiss R, Al Habbaa A, Petrovic Nagorni S, Ciric Zdravkovic S, Stanojevic D, Jankovic Tomasevic R, Atanaskovic V, Mitic V, Todorovic L, Dakic S, Park JS, Choi J, Kim Sh, Kwon Y, Jin H, Coppola C, Piscopo G, Galletta F, Maurea C, Esposito E, Barbieri A, Maurea N, Kaldararova M, Tittel P, Kantorova A, Vrsanska V, Kollarova E, Hraska V, Nosal M, Ondriska M, Masura J, Simkova I, Tadeu I, Azevedo O, Lourenco M, Luis F, Lourenco A, Planinc I, Bagadur G, Bijnens B, Ljubas J, Baricevic Z, Skoric B, Velagic V, Milicic D, Cikes M, Campanale CM, Di Maria S, Mega S, Nusca A, Marullo F, Di Sciascio G, El Tahlawi M, Abdallah M, Gouda M, Gad M, Elawady M, Igual Munoz B, Maceira Gonzalez Alicia A, Donate Betolin L, Vazquez Sanchez Alejandro A, Valera Martinez F, Sepulveda Sanchez P, Cervera Zamora A, Piquer Gil Marina M, Montero Argudo A, Naka K, Evangelou D, Lakkas L, Kalaitzidis R, Bechlioulis A, Gkirdis I, Tzeltzes G, Nakas G, Pappas K, Michalis L, Mansencal N, Bagate F, Arslan M, Siam Tsieu V, Deblaise J, El Mahmoud R, Dubourg O, Wierzbowska Drabik K, Plewka M, Bandera F, Generati G, Pellegrino M, Alfonzetti E, Labate V, Villani S, Gaeta M, Guazzi M, Grycewicz T, Szymanska K, Grabowicz W, Lubinski A, Sotaquira M, Caiani E, Garcia Gonzalez P, De La Espriella Juan R, Albiach Montanana C, Berenguer Jofresa A, Perez Bosca J, Cheng HL, Huang CH, Wang YC, Chou WH, Melnikov N, Kolunin G, Enina T, Sierraalta W, Le Bihan D, Barretto R, Assef J, Gospos M, Buffon M, Ramos A, Garcia A, Pinto I, Souza A, Mueller H, Reverdin S, Ehret G, Conti L, Dos Santos S, Abdel Moneim SS, Nhola LF, Huang R, Kohli M, Longenbach S, Green M, Villarraga HR, Bordun KA, Jassal DS, Mulvagh SL, Evangelista A, Madeo A, Piras P, Giordano F, Giura G, Teresi L, Gabriele S, Re F, Puddu P, Torromeo C, Suwannaphong S, Vathesatogkit P, See O, Yamwong S, Katekao W, Sritara P, Iliuta L, Szulik M, Streb W, Wozniak A, Lenarczyk R, Sliwinska A, Kalarus Z, Kukulski T, Weng KP, Lin CC, Hein S, Lehmann L, Kossack M, Juergensen L, Katus H, Hassel D, Turrini F, Scarlini S, Giovanardi P, Messora R, Mannucci C, Bondi M, Olander R, Sundholm J, Ojala T, Andersson S, Sarkola T, Karolyi M, Kocsmar I, Raaijmakers R, Kitslaar P, Szilveszter B, Tissue Doppler echocardiography research work, VFM international collaboration group, MTA SE Lendület Cardiovascular Imaging Research Group Heart, Vascular Center Semmelweis University Budapest Hungary, POLICINO, SALVATORE, Orii, M, Tanimoto, T, Yokoyama, M, Ota, S, Kubo, T, Hirata, K, Tanaka, A, Imanishi, T, Akasaka, T, Michelsen, M, Pena, A, Mygind, N, Hoest, N, Prescott, E, Abd El Dayem, S, Battah, A, Abd El Azzez, F, Ahmed, A, Fattoh, A, Ismail, R, Andjelkovic, K, Kalimanovska Ostric, D, Nedeljkovic, I, Andjelkovic, I, Rashid, H, Abuel Enien, H, Ibraheem, M, Vago, H, Toth, A, Csecs, I, Czimbalmos, C, Suhai, Fi, Kecskes, K, Becker, D, Simor, T, Merkely, B, D'Ascenzi, F, Pelliccia, A, Natali, B, Cameli, M, Lisi, M, Focardi, M, Corrado, D, Bonifazi, M, Mondillo, S, Zaha, V, Kim, G, Su, K, Zhang, J, Mikush, N, Ross, J, Palmeri, M, Young, L, Tadic, M, Ilic, S, Celic, V, Jaimes, C, Gonzalez Mirelis, J, Gallego, M, Goirigolzarri, J, Pellegrinet, M, Poli, S, Prati, G, Vriz, O, Di Bello, V, Carerj, S, Zito, C, Mateescu, A, Popescu, B, Antonini Canterin, F, Chatzistamatiou, E, Moustakas, G, Memo, G, Konstantinidis, D, Mpampatzeva Vagena, I, Manakos, K, Traxanas, K, Vergi, N, Feretou, A, Kallikazaros, I, Hewing, B, Theres, L, Dreger, H, Spethmann, S, Stangl, K, Baumann, G, Knebel, F, Uejima, T, Itatani, K, Nakatani, S, Lancellotti, P, Seo, Y, Zamorano, J, Ohte, N, Takenaka, K, Naar, J, Mortensen, L, Johnson, J, Winter, R, Shahgaldi, K, Manouras, A, Braunschweig, F, Stahlberg, M, Coisne, D, Al Arnaout, Am, Tchepkou, C, Raud Raynier, P, Diakov, C, Degand, B, Christiaens, L, Barbier, P, Mirea, O, Cefalu, C, Savioli, G, Guglielmo, M, Maltagliati, A, O'Neill, L, Walsh, K, Hogan, J, Manzoor, T, Ahern, B, Owens, P, Sengelov, M, Biering Sorensen, T, Jorgensen, P, Bruun, N, Fritz Hansen, T, Bech, J, Olsen, F, Sivertsen, J, Jensen, J, Marta, L, Abecasis, J, Reis, C, Ribeiras, R, Andrade, M, Mendes, M, D'Andrea, A, Stanziola, A, Di Palma, E, Martino, M, Lanza, M, Betancourt, V, Maglione, M, Calabro', R, Russo, M, Bossone, E, Vogt, Mo, Meierhofer, Ch, Rutz, T, Fratz, S, Ewert, P, Roehlig, Ch, Kuehn, A, Storsten, P, Eriksen, M, Remme, E, Boe, E, Smiseth, O, Skulstad, H, Ereminiene, E, Ordiene, R, Ivanauskas, V, Vaskelyte, J, Stoskute, N, Kazakauskaite, E, Benetis, R, Marketou, M, Parthenakis, F, Kontaraki, J, Zacharis, E, Maragkoudakis, S, Logakis, J, Roufas, K, Vougia, D, Vardas, P, Dado, E, Knuti, G, Djamandi, J, Shota, E, Sharka, I, Saka, J, Halmai, L, Nemes, A, Kardos, A, Neubauer, S, Kurnicka, K, Domienik Karlowicz, J, Lichodziejewska, B, Goliszek, S, Grudzka, K, Krupa, M, Dzikowska Diduch, O, Ciurzynski, M, Pruszczyk, P, Chung, H, Kim, J, Yoon, Y, Min, P, Lee, B, Hong, B, Rim, S, Kwon, H, Choi, E, Soya, O, Kuryata, O, Kakihara, R, Naruse, C, Inayoshi, A, El Sebaie, M, Frer, A, Abdelsamie, M, Eldamanhory, A, Ciampi, Q, Cortigiani, L, Simioniuc, A, Manicardi, C, Villari, B, Picano, E, Sicari, R, Ferferieva, V, Deluyker, D, Lambrichts, I, Rigo, J, Bito, V, Kuznetsov, V, Yaroslavskaya, E, Krinochkin, D, Pushkarev, G, Gorbatenko, E, Trzcinski, P, Michalski, B, Lipiec, P, Szymczyk, E, Peczek, L, Nawrot, B, Chrzanowski, L, Kasprzak, J, Todaro, M, Khandheria, B, Cusma Piccione, M, La Carrubba, S, Oreto, G, Di Bella, G, Gunyeli, E, Oliveira Da Silva, C, Sahlen, A, Spampinato, R, Tasca, M, Roche E., Silva J, Strotdrees, E, Schloma, V, Dmitrieva, Y, Dobrovie, M, Borger, M, Mohr, F, Einarsen, E, Cramariuc, D, Lonnebakken, M, Boman, K, Gohlke Barwolf, C, Chambers, J, Gerdts, E, Calin, A, Rosca, M, Beladan, C, Mirescu Craciun, A, Gurzun, M, Enache, R, Ginghina, C, Antova, E, Georgievska Ismail, Lj, Srbinovska, E, Andova, V, Peovska, I, Davceva, J, Otljanska, M, Vavulkis, M, Tsuruta, H, Kohsaka, S, Murata, M, Yasuda, R, Dan, M, Yashima, F, Inohara, T, Maekawa, Y, Hayashida, K, Fukuda, K, Migliore, R, Adaniya, M, Barranco, M, Miramont, G, Gonzalez, S, Tamagusuku, H, Abid, L, Ben Kahla, S, Charfeddine, S, Abid, D, Kammoun, S, Amano, M, Izumi, C, Miyake, M, Tamura, T, Kondo, H, Kaitani, K, Nakagawa, Y, Ghulam Ali, S, Fusini, L, Tamborini, G, Muratori, M, Gripari, P, Bottari, V, Celeste, F, Cefalu', C, Alamanni, F, Pepi, M, Obase, K, Mor Avi, V, Weinert, L, Lang, R, Teixeira, R, Monteiro, R, Garcia, J, Ribeiro, M, Cardim, N, Goncalves, L, Miglioranza, M, Muraru, D, Cavalli, G, Addetia, K, Cucchini, U, Mihaila, S, Veronesi, F, Badano, L, Galian Gay, L, Gonzalez Alujas, M, Teixido Tura, G, Gutierrez Garcia, L, Rodriguez Palomares, J, Evangelista Masip, A, Conte, L, Fabiani, I, Giannini, C, La Carruba, S, De Carlo, M, Barletta, V, Petronio, A, Mahmoud, H, Al Ghamdi, M, Ghabashi, A, Salaun, E, Zenses, A, Evin, M, Collart, F, Pibarot, P, Habib, G, Rieu, R, Fabregat Andres, O, Estornell Erill, J, Cubillos Arango, A, Bochard Villanueva, B, Chacon Hernandez, N, Higueras Ortega, L, Perez Bosca, L, Paya Serrano, R, Ridocci Soriano, F, Cortijo Gimeno, J, Mzoughi, K, Zairi, I, Jabeur, M, Ben Moussa, F, Mrabet, K, Kamoun, S, Fennira, S, Ben Chaabene, A, Kraiem, S, Schnell, F, Betancur, J, Daudin, M, Simon, A, Lentz, P, Tavard, F, Hernandes, A, Carre, F, Garreau, M, Donal, E, Abduch, M, Vieira, M, Antunes, M, Mathias, W, Mady, C, Arteaga, E, Alencar, A, Tesic, M, Djordjevic Dikic, A, Beleslin, B, Giga, V, Trifunovic, D, Petrovic, O, Jovanovic, I, Petrovic, M, Stepanovic, J, Vujisic Tesic, B, Cha, J, Kim, Kh, Bergler Klein, J, Geier, C, Maurer, G, Gyongyosi, M, Cortes Garcia, M, Oliva, M, Navas, M, Orejas, M, Rabago, R, Martinez, M, Briongos, S, Romero, A, Rey, M, Farre, J, Ruisanchez Villar, C, Ruiz Guerrero, L, Rubio Ruiz, S, Lerena Saenz, P, Gonzalez Vilchez, F, Hernandez Hernandez, J, Armesto Alonso, S, Blanco Alonso, R, Martin Duran, R, Gonzalez Gay, M, Novo, G, Marturana, I, Bonomo, V, Arvigo, L, Evola, V, Karfakis, G, Lo Presti, M, Verga, S, Novo, S, Petroni, R, Acitelli, A, Bencivenga, S, Cicconetti, M, Di Mauro, M, Petroni, A, Romano, S, Penco, M, Park, S, Kim, S, Kim, M, Shim, W, Majstorovic, A, Ivanovic, B, Driessen, Mm, Meijboom, F, Mertens, L, Dragulescu, A, Friedberg, M, De Stefano, F, Santoro, C, Buonauro, A, Muscariello, R, Lo Iudice, F, Ierano, P, Esposito, R, Galderisi, M, Sunbul, M, Kivrak, T, Durmus, E, Yildizeli, B, Mutlu, B, Rodrigues, A, Daminello, E, Echenique, L, Cordovil, A, Oliveira, W, Monaco, Ch, Lira, E, Fischer, Ch, Morhy, S, Mignot, A, Jaussaud, J, Chevalier, L, Lafitte, S, Curci, V, Alvino, F, Ikonomidis, I, Pavlidis, G, Lambadiari, V, Kousathana, F, Triantafyllidi, H, Varoudi, M, Dimitriadis, G, Lekakis, J, Cho, J, Cho, E, Yoon, H, Ihm, Sh, Lee, J, Molnar, Aa, Kovacs, A, Apor, A, Tarnoki, A, Tarnoki, D, Horvath, T, Maurovich Horvat, P, Jermendy, G, Kiss, R, Al Habbaa, A, Petrovic Nagorni, S, Ciric Zdravkovic, S, Stanojevic, D, Jankovic Tomasevic, R, Atanaskovic, V, Mitic, V, Todorovic, L, Dakic, S, Park, J, Choi, J, Kim, Sh, Kwon, Y, Jin, H, Coppola, C, Piscopo, G, Galletta, F, Maurea, C, Esposito, E, Barbieri, A, Maurea, N, Kaldararova, M, Tittel, P, Kantorova, A, Vrsanska, V, Kollarova, E, Hraska, V, Nosal, M, Ondriska, M, Masura, J, Simkova, I, Tadeu, I, Azevedo, O, Lourenco, M, Luis, F, Lourenco, A, Planinc, I, Bagadur, G, Bijnens, B, Ljubas, J, Baricevic, Z, Skoric, B, Velagic, V, Milicic, D, Cikes, M, Campanale, Cm, Di Maria, S, Mega, S, Nusca, A, Marullo, F, Di Sciascio, G, El Tahlawi, M, Abdallah, M, Gouda, M, Gad, M, Elawady, M, Igual Munoz, B, Maceira Gonzalez Alicia, A, Donate Betolin, L, Vazquez Sanchez Alejandro, A, Valera Martinez, F, Sepulveda Sanchez, P, Cervera Zamora, A, Piquer Gil Marina, M, Montero Argudo, A, Naka, K, Evangelou, D, Lakkas, L, Kalaitzidis, R, Bechlioulis, A, Gkirdis, I, Tzeltzes, G, Nakas, G, Pappas, K, Michalis, L, Mansencal, N, Bagate, F, Arslan, M, Siam Tsieu, V, Deblaise, J, El Mahmoud, R, Dubourg, O, Wierzbowska Drabik, K, Plewka, M, Bandera, F, Generati, G, Pellegrino, M, Alfonzetti, E, Labate, V, Villani, S, Gaeta, M, Guazzi, M, Grycewicz, T, Szymanska, K, Grabowicz, W, Lubinski, A, Sotaquira, M, Caiani, E, Garcia Gonzalez, P, De La Espriella Juan, R, Albiach Montanana, C, Berenguer Jofresa, A, Perez Bosca, J, Cheng, Hl, Huang, Ch, Wang, Yc, Chou, Wh, Melnikov, N, Kolunin, G, Enina, T, Sierraalta, W, Le Bihan, D, Barretto, R, Assef, J, Gospos, M, Buffon, M, Ramos, A, Garcia, A, Pinto, I, Souza, A, Mueller, H, Reverdin, S, Ehret, G, Conti, L, Dos Santos, S, Abdel Moneim, S, Nhola, Lf, Huang, R, Kohli, M, Longenbach, S, Green, M, Villarraga, Hr, Bordun, Ka, Jassal, D, Mulvagh, Sl, Evangelista, A, Madeo, A, Piras, P, Giordano, F, Giura, G, Teresi, L, Gabriele, S, Re, F, Puddu, P, Torromeo, C, Suwannaphong, S, Vathesatogkit, P, See, O, Yamwong, S, Katekao, W, Sritara, P, Iliuta, L, Szulik, M, Streb, W, Wozniak, A, Lenarczyk, R, Sliwinska, A, Kalarus, Z, Kukulski, T, Weng, Kp, Lin, Cc, Hein, S, Lehmann, L, Kossack, M, Juergensen, L, Katus, H, Hassel, D, Turrini, F, Scarlini, S, Giovanardi, P, Messora, R, Mannucci, C, Bondi, M, Olander, R, Sundholm, J, Ojala, T, Andersson, S, Sarkola, T, Karolyi, M, Kocsmar, I, Raaijmakers, R, Kitslaar, P, Szilveszter, B, Tissue Doppler echocardiography research, Work, VFM international collaboration, Group, MTA SE Lendület Cardiovascular Imaging Research Group, Heart, Vascular Center Semmelweis University Budapest, Hungary, and Policino, Salvatore

Subjects
Medical education, business.industry, Medicine, Radiology, Nuclear Medicine and imaging, Friday 5 December 2014, General Medicine, Session (computer science), Cardiology and Cardiovascular Medicine, business
Published
2014

24. Impact of clinical and genetic findings on the management of young patients with Brugada syndrome

Author

Andorin, A, Behr, E, Denjoy, I, Crotti, L, Dagradi, F, Jesel, L, Sacher, F, Petit, B, Mabo, P, Maltret, A, Wong, L, Degand, B, Bertaux, G, Maury, P, Dulac, Y, Delasalle, B, Gourraud, J, Babuty, D, Blom, N, Schwartz, P, Wilde, A, Probst, V, Behr, ER, Wong, Lc, Gourraud, JB, Blom, NA, Schwartz, PJ, Wilde, AA, Andorin, A, Behr, E, Denjoy, I, Crotti, L, Dagradi, F, Jesel, L, Sacher, F, Petit, B, Mabo, P, Maltret, A, Wong, L, Degand, B, Bertaux, G, Maury, P, Dulac, Y, Delasalle, B, Gourraud, J, Babuty, D, Blom, N, Schwartz, P, Wilde, A, Probst, V, Behr, ER, Wong, Lc, Gourraud, JB, Blom, NA, Schwartz, PJ, and Wilde, AA

Abstract

Background Brugada syndrome (BrS) is an arrhythmogenic disease associated with sudden cardiac death (SCD) that seldom manifests or is recognized in childhood. Objectives The objectives of this study were to describe the clinical presentation of pediatric BrS to identify prognostic factors for risk stratification and to propose a data-based approach management. Methods We studied 106 patients younger than 19 years at diagnosis of BrS enrolled from 16 European hospitals. Results At diagnosis, BrS was spontaneous (n = 36, 34%) or drug-induced (n = 70, 66%). The mean age was 11.1 ± 5.7 years, and most patients were asymptomatic (family screening, (n = 67, 63%; incidental, n = 13, 12%), while 15 (14%) experienced syncope, 6(6%) aborted SCD or symptomatic ventricular tachycardia, and 5 (5%) other symptoms. During follow-up (median 54 months), 10 (9%) patients had life-threatening arrhythmias (LTA), including 3 (3%) deaths. Six (6%) experienced syncope and 4 (4%) supraventricular tachycardia. Fever triggered 27% of LTA events. An implantable cardioverter-defibrillator was implanted in 22 (21%), with major adverse events in 41%. Of the 11 (10%) patients treated with hydroquinidine, 8 remained asymptomatic. Genetic testing was performed in 75 (71%) patients, and SCN5A rare variants were identified in 58 (55%); 15 of 32 tested probands (47%) were genotype positive. Nine of 10 patients with LTA underwent genetic testing, and all were genotype positive, whereas the 17 SCN5A-negative patients remained asymptomatic. Spontaneous Brugada type 1 electrocardiographic (ECG) pattern (P =.005) and symptoms at diagnosis (P =.001) were predictors of LTA. Time to the first LTA event was shorter in patients with both symptoms at diagnosis and spontaneous Brugada type 1 ECG pattern (P =.006). Conclusion Spontaneous Brugada type 1 ECG pattern and symptoms at diagnosis are predictors of LTA events in the young affected by BrS. The management of BrS should become age-specific, and prevention of

Published
2016

26. Intravenous NPA for the treatment of infarcting myocardium early; InTIME-II, a double-blind comparison of single-bolus lanoteplase vs accelerated alteplase for the treatment of patients with acute myocardial infarction

Author

Braunwald, E., Neuhaus, K. -L., Antman, E., Chew, P., Skene, A., Wilcox, R., Ambrosioni, E., Anderson, J., Apetrei, E., Bata, I., Carrageta, M., Col, J., Dalby, A., Davies, R., Deckers, J., Eichman, D., Grande, P., Greene, R., Gurfinkel, E., Heikkilä, J., Henry, T., Hillis, D., Hochman, J., Huber, K., Kostis, J., Klinke, P., López-Sendón, J., Mckendall, G., Móller, B., Moore, P., Morris, A., Mueller, H., Östör, E., Oto, A., Ruda, M., Sadowski, Z., Schweiger, M., Sequeira, R., Shah, P., Shannon, R., Smith, B., Sobel, B., Steingart, R., Tebbe, U., Toman, J., Traboulsi, M., Vahanian, A., Warnica, J. W., Willerson, J., Deitchman, D., Davidson, L., Folgia, T., Foxley, A., Goodman, J., Hauck, C., Henry, D., Mccabe, C., Pangerl, A., Thomson, A., Wagner, M., Kennedy, J. W., Cairns, J., Demets, D., Julian, D., Simoons, M., Charlesworth, A., Easton, J. D., Ferbert, A., Feske, S., Kuhn, P., Moseley, J., Rogg, J. M., Reichmann, H., Sloan, M., von Kummer, R., Zamani, A., Coulter, S., Giugliano, R., Skene, A. M., Ardill, R., Ince, Y., Peters, A., Ward, K., Wolf, L., Curtis, N., De Brés, J., Stead, S., Watson, S., Cutler, S., Friedman, J., Helfrick, R., Williams, S., Klimovsky, J., Kumagai, S., Adams, E., Anderson, C., Bauhuber, I., Bennett, L., Biro, E., Boyce, E., Bregman, B., Carvalho, P., Ciganovic, D., Csukas, M., Cuenca, P., De Cuyper, S., Diez, P., Dijkhuizen, M., Dille-Amo, C., Gonzalez-Santis, A., Gursoy, M., Hammarstrom, K., Harasta, E., Ingman, E., Kelemen, B., Keulen, I., Koren, A., Langthaler, G., Lemaire, F., Little, I., Montalban, C., Nijssen, K., Neumueller, I., Palander, M., Pekuri, T., Persson, U., Pilz, J., Oudotova, S., Pisklakov, V., Proinov, F., Ptaszynska, A., Read, J., Retei, S., Romeyer, F., Romanini, M., Saar, L., Salein, D., Samsonov, M., Simeon-Dubach, D., Simmonds, J., Skaza, M., Skvortsova, N., Smidlova, Z., Spitzerova, H., Strijdveen, I., Szajewski, T., Ugurnal, B., Valcarce, M., van Rompaey, I., Walker, A., Zak, E., Zimova, N., Barrero, C., Beck, E., Bruno, M. L., Caccavo, A., Cagide, A., Campo, A., Cermesoni, R., Chahin, M., Dutra, O., Estrada, J., Falu, E. A., Gagliardi, J., Garre, L. E., Liprandi, A. S., Luciardi, H., Mautner, B., Muntaner, J., Nau, G., Salzberg, S., Santopinto, J., Sinisi, A., Torres, H., Eber, B., Elliott, P., Hiemetsberger, H., Juhasz, M., Kühn, P., Leisch, F., Niktardjam, M., Reisinger, J., Schmalix, G., Schuster, R., Sihorsch, K., Silberhauer, K., Slany, J., Steinbach, K., Tragl, K. H., Valentin, A., Al Shwafi, K., Dasnoy, P., De Clippel, M., de Meester, A., De Raedt, H. J. L. P., Emonts, M., Evrard, P., Eycken, M., Geboers, M., Heyndrickx, G., Lauwers, K., Mitrie, K., Pirenne, B., Renard, M., Somers, Y., Timmermans, P., Van Kuyk, M., Van Mieghem, W., Vermeulen, J., Verrostte, J. M., Albuquerque, D., Ayoub, J. C. A., Carvalho, A., Cesar, L., Gebara, O., Golin, V., Knobel, E., Leaes, P., Neto, J. A. M., Nicolau, J. C., Piegas, L. S., Rabelo, A., Rassi, A., Sila, L., Simao, A. F., Ashton, T., Baillie, H., Bhargava, R., Bota, G., Cameron, W., Chan, N., Chan, Y. K., Daly, P. A., Darcel, I., Davies, E., Desjardin, L., Dhingra, S., Ducas, J., Ervin, F. L., Fortin, C., Fowlis, R., Fulop, J., Furey, M., Gagnon, S., Gebhardt, V., Giannaccro, P., Gosselin, G., Graham, J., Grondin, F., Heath, J. W., Henderson, M., Hilton, D. R., Hiscock, J., Hui, W., Kaza, L., Kesselman, T., Kouz, S., Kucerak, M., Lahoude, N., Lamothe, M., Lebouthillier, P., Lenis, J., Levesque, P., Lopez, J. F., Lubelsky, B., Macritchie, D., Mayer, J. -P., Mcdowell, J. D., Montigny, M., Orestien-Lyall, T., Parekh, P., Pistawka, K., Price, J. B., Pruneau, G., Quinn, B., Reid, B. R., Richmond, M., Rose, B., Schuld, R., Sharma, N. K., Shetty, P., Stanton, E., Strauss, H. D., Sussex, B., Theroux, P., Turabian, M., Turner, C., Vizel, S., Walker, M., Weeks, A., Winkler, L., Zacharias, G., Zimmerman, R., Bartolucci, J., Castro, P., Diaz, M. A., Illanes, G., Potthoff, S., Sanchez, E. C., Silva, L. M., Yovanovich, J., Zanetti, F. L., Alan, D., Balázová, K., Boček, P., Cerny, J., Fischerova, B., Holub, M., Hradec, J., Janota, T., Janský, P., Kasper, J., Klimsa, Z., Motovská, Z., Pleva, L., Pluhacek, L., Pšenčka, M., Semrád, B., Spinar, J., Staněk, V., Štípal, R., Suítil, P., Vítovec, J., Wichterie, D., Widimský, P., Zeman, K., Andersen, C. B., Kriegbaum, J., Nielsen, N., Nielsen, P. E., Schou, J. B., Teesalu, R., Voitk, J., Haapamäki, H. V. H., Halkosaari, M., Härkönen, M., Jägerholm, S., Kärjä-Koskenkari, P., Karthunen, P., Kesäniemi, Y. A., Koskivirta, H., Lehto, P., Lilja, M., Paakkinen, S., Palomäki, A. K., Pietilä, K., Tuominen, J., Viopio-Pulkki, L., Ylönen, H., Adi, I., Admant, P., Akadirik, A., Alagha, Z., Alhabaj, S., Amat, G., Andre, A. A., Apffel, F., Aswad, K., Baradat, G., Bareiss, P., Barthers, F. B., Baudet, M., Baudouy, M., Bearez, E. M., Berthou, J. D., Berzin, B., Bessede, G., Blanc, J. J., Bocara, A., Bonneau, A., Bourdad, C., Bouvier, J. M., Cassagnes, J., Cassat, A., Cazaux, P., Charbonnier, B., Clementy, J., Cohen, A., Coisne, D., Colin, P., Croizier, O., D’Hautefeuille, B., D’Ivernois, C., Daumas, P. L., Dauphin, C. L., Deforet, M. F., Degand, B., Dequeker, J. L., Dickele, M. C., Dugrand, P., Durand, S., Ebagosti, A., Elharrar, C., Equine, O., Fichter, E., Flork, L., Fouche, R., Fourchard, V., Fourme, T., Fournier, P. Y., Funck, F., Galley, D., Garbarz, E., Ghadban, W., Gladin, M., Grall, J. Y., Grand, A., Gryman, R., Guillard, N., Guillo, P., Haftel, Y., Hannebicque, G., Henry, R., Huret, J. F., Janin-Magnificat, L., Jarnier, J., Joly, A., Kamal, H., Khalife, A., Roynard, J. L., Lang, M., Lapeyssonnie, A., Ledain, L., Lejeune, P., Lemetayer, L., Lepori, R., Lombart, A., Lusson, J. R., Magnin, O., Marquand, A., Martelet, M. M., Martelli, A., Mathurin, C., Mentre, B., Messager, D., Morizot, M., Mouallem, M. J., Mouhoub, O., Mycimski, C., Nallet, O., Olive, T., Pacouret, G., Palcoux, M. C., Poulard, J. E., Pruvost, A., Quiret, J. C., Richard, C., Richard, P., Rickaud, P., Riehl-Aleil, V., Rifai, A., Rocher, R., Rotreff, P., Segrestin, B., Slama, M. S., Sultan, P., Tabone, X., Talbodec, A., Tissot, M. T., Toussaint, C., Veyrat, A., Zerrouk, Z., Adamczak, M., Altmann, E., Altybernd, B., Andreassen, G., Andresen, D., Appenrodt, H., Bachmann, S., Bäcker, U., Beckert, U., Behr, H. M., Beier, W., Beier, T., Berger, D., Bernsmeier, R., Beythien, R. D., Biechl, E., Biedermann, G., Bischoff, K. O., Blerich, J., Boch, H. B., Bonzel, T., Both, A. R., Breidenbach, K., Breuer, M., Breuer, H. W. M., Brunkhorst, F. B., Bruns, A., Bundschu, H. D., Burkhardt, W., Busse, H. J., Caesar, K., Cailloud, J., Chlosta, A., Chorlanopoulos, E., Consemüller, S., Decker, W., Dichgans, M., Dick, R., Diederich, K. W., Dienst, C., Dietz, A., Dißmann, R., Ditter, H., Doering, W., Drost, H., Dundalek, E. D., Eckardt, D., Edelmann, A., Eggeling, T., Eggert, G., Eichner, R., Endres, C., Engberding, R., Engel, H. J., Faehnrich, A., Fischer, J. L., Flor, A., Forycki, F. Z. F., Froböse, H. J., Fruehauf, T., Fuchs, M., Geiser, R., Geletneky, J., Gerdes, H., Gerecke, B., Gesing, S., Gieser, H., Girth, E., Glogner, P., Glover, M., Goetz, J., Goetz, H., Göttfert, G., Gottwik, M., Gregori, B., Grieshaber, M., Großmann, C., Gruber, G., Gunold, H., Häßler, W. H., Hackenjos, B., Hader, O., Hamer, H., Harmjanz, D., Hasst, G., Haun, H., Hauptmann, K. E., Hegge, F. J., Heinze, A., Heinze, R., Henrichs, K. J., Hergenröther, H., Herrmann, F., Herzig, C., Hey, D., Hill, S., Hinzmann, S., Hoffmann, S., Höfs, T., Höhler, H., Holle, G., Höltman, B. J., Horacek, T., Hossmann, V., Hübner, F. S., Hülskamp, C., Hunecke, R., Hust, M., Jaeckh, G., Jebens, C., Jennen, E., Jost, M., Justiz, R., Kallmann, L., Kalscheur, F., Kaschner, W., Kaspar, W., Kauder, E., Keitel, B., Keller, H., Kemkes, T., Kerler, N., Kester, M., Kettner, W., Kilp, M., Kirklies, A., Klaus, A., Klein, H. H., Klenböck, J. R., Kley, H. K., Klingenbeck, R., Koch, H., Kohler, B., Kohler, J., Kolloch, R., Konermann, M., Körber, H. G., Kother, T. K., Kötter, V., Kottwitz, B., Kozariszcsuk, G., Kracht, T., Kratzsch, G., Kreft, H. U., Kreuter, G., Krönert, H., Krönig, B., Krueger, E., Krülls-Münch, J., Kuckuk, H., Kuelschbach, M., Kuhrt-Lassay, O. W., Kummerhoff, P. W., Kunevt, R., Kurth, C. U., Lang, C., Lange, C., Langhoff, R., Laskus, A., Lazarus, P., Lehmann, H. U., Lenga, P., Lengfelder, W., Leupolz, W., Limbourg, P., Loos, U., Lucanus, W., Machill, K., Mäckel, P., Mackes, K. G., Maier, S., Makowski, B., Mandok, J., Manz, M., Mäurer, W., Meier, F., Meier, J., Menges, M., Merx, W., Meurers, G., Michels, U., Mickeler, C. H., Mons, D., Moos, E., Mueller, R., Müller, G., Nast, H. P., Naumann, G., Nebelsieck, H., Neubaur, J., Niederer, W., Nitsch, J., Noack, J., Nogai, K. F. W., Oberheiden, A., Obst, R., Ochs, H. R., Odemar, F., Odenthal, H. J. B., Offers, E., Öhl, S., Ohlmeier, H. A. R. M., Patzer, P., Pech, A., Peters, U., Petry, U., Pietschmann, G. J., Pistner, W., Plappert, B., Pohlmann, W. K., Pollock, B., Presser, H. J., Przytarski, K., Puerner, K. L., Raouf, N., Reike, N., Reil, G. H., Reinhard, U., Riebeling, V., Ritzmann, M., Rödder, J., Roth, E., Rüdelstein, R., Saborowski, F., Sauter, B., Sceffler, N., Schartl, A., Schifferdecker, E., Schlotterbeck, K. P., Schmidt, J., Schmidt-Dannert, D. R., Schmidt-Klewitz, H., Schmitz, H. J., Schnebelt, T., Schneider, H. L., Schneider, F. J., Schoeller, R., Scholz, D., Schoppe, W. D., Schreiner, G., Schroeder, J., Schuh, N., Schulte, K. L., Schulze, H., Schulze, H. D., Schuster, P., Schuster, H. P., Schweizer, P., Sechtem, U., Sedlmaier, H. P., Segel, S., Sehnert, W., Seidel, F., Siedentopf, K., Simon, H., Sodomann, C. P., Solbach, C., Sorges, E., Stabenow, S., Stadler, K. P., Stammwitz, E., Stein, U., Sternberg, H., Stiepak, C., Stockmann, M., Straus, W., Striegel, H., Struch, E., Strupp, G., Taubert, T. B. T., Thoeming, B., Thoß, A., Tinnappel, J., Tomsik, H., Topp, H., Troost, S., Öberreiter, A., Uebis, R., Ungler, T., Urbaszek, W., Vöhringer, H. F., von Arnim, T., von Leitner, E. R., von Löwis of Menar, A., von Mengden, H. J., von Smekal, P., Voss, W., Wacker, P., Warning, A., Warzecha, A., Wefers, U., Wehr, M., Weigel, H., Weissthanner, F., Weller, P., Werner, M., Wette, A., Wichert, H., Wielage, T., Wiese, U., Wilbrand, T. B., Wilhelms, E., Wilmsmann, G., Wolf, F. H., Wolf, T., Wonhas, F. C. M., Zastrow, B., Zeymer, U., Ziruler, S., Ziss, W., Zölch, K. A., Zwirner, K., Becker, D., Bosko, M., Csillag, I., Ermenyi, A., Fogas, J., Heltai, K., Jánosi, A., Katona, A., Kiraly, C., Kiss, B., Kutor, G., Mizik, R., Molnar, T., Mühl, M., Nagy, D., Palacti, I., Rudas, L., Sárosi, I., Simon, K., Sitkel, E., Sydó, T., Szaboki, F., Szikla, K., Szönyi, T., Timar, S., Vándor, L., Zamolyl, K., Walsh, M., Caspi, A., Swissa, M., Badano, L., Baldacci, G., Balli, E., Banda, D., Baretta, G., Boccalatte, A., Borgatti, M. L., Branzi, A., Burelli, C., Capelletti, D., Capucci, A., Caragiulo, D., Carbonieri, E., Cassin, M., Ceci, V., Cocchieri, M., Coletta, C., Conte, E., Contini, G. M., Corsini, G., D’Annunzio, E., De Blasi, M., De Luca, I., Delciterna, F., Di Pasquale, G., Diguardo, G., Fattore, L., Ferraiuulo, G., Finardi, A., Fioretti, P. M., Giunta, G., Guiducci, U., Guzzardi, G., Horando, G., Ignone, G., Lazzaroli, A., Levantesi, D., Liberati, R., Losi, E., Macor, F., Mangiameli, S., Martines, C., Meinardi, F., Morgera, T., Morozzi, L., Mostacci, M., Naccarella, F. F., Ottani, F., Palamara, A., Pani, A., Paperini, L., Pes, R., Pesola, A., Porzio, A., Raviele, A., Ricci, S., Rosi, A., Rossi, R., Rotiroti, D., Rusconi, L., Sabino, G., Saccone, V., Sanna, A., Scaramuzzino, G., Scorcu, G. P., Semprini, F., Severini, D., Staniscia, D., Tantalo, L., Tartagni, F., Terrosu, P., Tondelli, S., Trichero, R., Uslenghi, E., Vajola, S. F., Vetrano, A., Violi, E., Zardini, P., Zingarini, G. L., Zobbi, G., Zuin, G., Kalnins, U., Cârvekülg, A., Laanoca, J., Iacis, J., Lankiene, L., Laucevicius, A., Lukoseviciute, A., Palsauskaite, R., Petrauskiene, B., Soopóld, W., Uuetoa, H., Vilks, J., Vitonyte, R., Zakke, I., Dorantes, J., Hernández, H., Jerjes, C., Leva Garza, J. L., Martinez, C., Anneveldt, A., Baars, H. F., Baldew, S. C., Bendermacher, P. E. F., Boersma, L. V. A., Bos, R. J., Breedveld, R. W., Bruggink, P. W. F., Ciampricotti, R., Darmanata, J. I., de Porto, A. E., de Weerd, G. J., Deckers, J. W., Freericks, M. P., Hillebrand, F. A., Kerker, J. P., Koenen, J. C., Kofflard, M. G. M., Liem, K. L., Liem, A. H., Linssen, G. C. M., Lionarons, R. J., Peters, J. R. M., Posma, J. P., Saat, E. W. M., Savalle, L. H., Smits, W. C. G., Suttorp, M. J., Tans, A. C., Troquay, R. P. Th., van Beek, G. J., van Boven, A. J., Van der Heijden, R., Van Hessen, A., van Langeveld, R. A. M., van Lier, T. A. R., van Loo, L. W. H., van Wijngaarden, J., van Ziejl, L. G. P. M., Veerhoek, M. J., Vermer, F., Werner, H. A., Graven, T., Klykken, B., Meyerdieks, O., Omland, T. M., Otterstad, J. E., Pedersen, T., Rød, R., Banaszewski, M., Bednarkiewicz, Z., Bojarski, G., Ceremuzyñski, L., Czestochowska, E., Gajewski, M., Galewicz, M., Gorski, J., Grabczewska, Z. S., Gruchaka, M., Janicki, K., Janion, M., Jaworska, K., Jezewska, M., Kakol, J., Kizciuk, M., Kleinrok, A., Kolodziej, P., Komorowski, P., Konopka, A., Kopaczewski, J., Korecki, J., Kornacewicz-Jach, Z., Kowalewski, M., Kratochwil, D., Krolczyk, J., Krzminska-Pakula, M., Kurek, P., Kurowski, M., Kurpesa, M., Kurzawski, J., Kwiecien, R., Lenartowski, L., Lewandowski, M., Loboz-Grudzieñ, K., Luczak, G., Maliñski, A., Michalski, M., Musial, W., Nartowicz, E., Nowicka, A., Odyniec, A., Pasyk, S., Prastowski, W., Przybylski, A., Raczynska, A., Rodzik, J., Romanowski, M., Rynkiewicz, A., Rzyman, M., Sidorowicz, A., Sledziona, M., Sobiczewski, W., Sobkowicz, B., Sobolewska, J., Sokalski, L., Stepinska, J., Sterlinski, M., Stopinski, M., Świątecka, G., Szpernal, Z., Tarnowska, H., Trzos, E., Ujda, M., Wierzchowiecki, M., Wodynska, T., Wojciechowski, D., Wrabec, K., Wrzesinski, K., Zuk, P., Albuquergue, A., Costa, A., Cunha, D., Ferreira, D., Ferreira, R., Gaog Leiria, J. M., Pimenta, A., Rufino, E., Vasconcelos, J., Aldica, M., Balanescu, S., Bruckner, I. V., Capalneanu, R., Florescu, N., Georgescu, C. S., Cherasim, L., Ginshina, C., Merenta, A., Parvu, O., Radutiu, S., Savulescu, I., Vita, I., Averkov, O., Bokarev, I. N., Gratsiansky, N., Grigoriev, Y., Gruzdev, A., Kakhnovsky, I., Kheevehuk, T. V., Khrustalev, O., Kobalava, Y., Konoratieva, T. B., Koukline, Vladimir, Martiouchov, S., Pavlikova, E., Poskotinov, I., Rogalev, K., Sinopainikov, A., Syrkin, A., Tereschenko, S. T., Yavelov, I., Zavolghin, S., Čurilla, E., Kohn, R., Kovář, F., Murín, J., Poliačik, P., Drinovec, I., Horvat, M., Krivec, B., Markež, J., Pareznik, R., Pehnec, Z., Resman, J., Sifrer, F., Skale, R., Trinkaus, D., Voga, G., Baig, M. M. E., Blomerus, P., Botha, B. P., Burgess, L., Duncan, D., Duncan, D. I., Gillmer, D., Govender, N., Jardine, R. J., Kok, A., Manga, P., Naidu, R. K., Rajput, M. C., Ranjith, N., Roos, J. S., Snyders, F. A., Steingo, L., Stern, A., Tayob, F. Z., Vythilingum, S., Alonso-Orcajo, N., Arribas Jimenez, A., Ayestaran, J. I., Balsera, B. B. G., Barras, C., Castro, A., Cobo, N., Duque, A., Garcia, M. J., Goiriena, P., Gonzalez-Valdayo, M., Gulias Lopez, J. M., Jimenez Gomez, P., Lopez Garanda, V., Martín Santos, F., Nogueira, R., Pabon Osuna, P., Ponce De Leon, E., Quesada Dorador, A., Paya Serrano, R., Rodriguez, L., Rodriguez, M., Rubio, F., Ruiz-Salmeron, R., Solar, J., Toquero, J., Velasco, J., Vilar Herrero, V., Vizcaino, M., Wancisidor, X., Basilier, E., Birgersdotter, V., Björnsdotter, E., Bjurman, A., Hagström, D., Hallin, I., Hansen, O., Hemmingson, L. O., Lundkvist, L., Lycksell, M., Möller, B., Nolgard, P., Sjölund, G., Stjerna, A., Angehrn, W., de Benedetti, E., Diethelm, M., Gallino, A., Plebani, G., Vögelin, H. P., Wojtyna, W., Akgöz, H., Akgün, G., Akyürek, O., Batur, M. K., Bayata, S., Deger, N., Emel, O., Gürgün, C., Korkmaz, M. E., Kozan, O., Kumbasar, D., Muderrisoglu, H., Nisanci, Y., Ozin, B., Ozsaruhan, O., Payzin, S., Postaci, N., Sozcuer, H., Tamci, B., Topuzoglu, F., Türkoglu, C., Tutar, E., Ulucam, M., Ulusoy, T., Umman, B., Yalçinkaya, S., Yesil, M., Zoghi, M., Adams, P. C., Ahir, S., Ahsan, A. J., Akhtar, J., Albers, C. J., Al-Khafaji, M. N., Anderson, N., Bailey, R. J., Bain, R. J. I., Basu, A., Beal, A., Boyle, R. M., Brown, N., Campbell, S., Card, D., Cross, S. J., Davies, P., Davis, E. T. L., Dean, J. W., Deaner, A., Devine, M. A., Dhawan, J., Doig, J. C., Dubrey, S., Dunn, P. G., Dwight, J., Ecob, R., Fitzpatrick, H., Fletcher, S., Francis, C. M., Gershlick, A. H., Glennon, P. E., Goodfield, N. E., Grabau, W. J., Gray, M., Gray, K. E., Heath, J., Hendry, W. G., Highland, J., Hogg, K., Irving, J. B., James, M. A., Jennings, K., Joy, M., Kadr, H. H., Kahn, S., Keeling, P. J., Keir, P. M., Kemp, T. M., Kinaird, J., Kinsey, C., Knowles, K., Kooner, J. S., Lahiri, A., Lawson, C., Lewis, R., Macdermott, A. F. N., Mackay, A., Macleod, D. C., Mccance, A. J., Morrison, A., Mortimer, M., Mulvey, D., Murphy, J. J., Murray, S., Muthusamy, R., Myers, A., Nicolson, V. G., Northridge, D., Odemuyiwa, S., Oldroyd, K. G., Oliver, R. M., Pell, A. C. H., Pohl, J. E. F., Price, B., Quereshi, N., Rae, A. P., Reader, S., Reid, D. S., Reynolds, G. W., Robinson, A., Robson, R. H., Rodger, J. C., Rodrigues, E., Rose, E. L., Rowlands, D. B., Rowley, J. M., Rozkovec, A., Shreeve, J., Siklos, P., Smith, R. H., Sneddon, J. F., Somasundram, U., Squire, I., Stephens, J. D., Stephens-Lloyd, A., Strand, J. M., Stuart, J., Sutaria, N., Swan, J., Tait, G. W., Thomas, R. D., Thompson, M. A., Tildesley, G., Travill, C. M., Treadgold, J. A., Trelawney, J. M. S., Turner, D., Vallance, B. D., Wallbridge, D., Weissberg, P. L., White, E., Wicks, M., Wilcox, R. G., Wilkinson, P., Wiltshire, J. E., Wright, A., Andrea, B., Attassi, K., Bahr, R., Banas, J., Baran, K., Belknap, M., Bensman, M., Bertolet, B., Besley, D., Bethala, V., Betzu, R., Bhalla, R., Bhargava, M., Binder, A., Birkhead, R., Bodine, K., Brewer, D., Carey, S., Chengot, M., Coppola, J., Cragg, D., D’Arcy, B., Denny, D. M., Dilorenzo, P., Dixon, E., Doorey, A., Doty, D., Doty, W., Drossner, M., Eisenberg, P., Falco, T., Feldman, R., Freman, I., Frey, M., Garcia, J., Glassman, J., Goldman, S., Gomez, M., Gonzalez, M., Goodfield, P., Gottlieb, S., Grech, D., Hack, T., Haffey, T., Hanson, J., Havranek, E., Hermany, P., Hernandez, H., Herron, R., Hession, W., Hines, J., Hundley, R., Jacobs, W. C., Jerjes-Sanchez, C., Jerome, S., Josephson, R., Kalan, J., Kawalsky, D., Khan, A., Kmetzo, K., Kraemer, M., Lader, E., Landis, J., Lash, J., Leber, R., Leimbach, W., Leiva Garza, J. -L., Maddox, W., Magorien, R., Mahapatra, S., Mantecon, I., Mendelson, R., Miklin, J., Milas, J., Miller, R., Molk, B., Monrad, E. S., Morrison, J., Morse, H., Neustel, M., Nichols, D., Niederman, A., Nygaard, T., O’Connor, R., O’Riordan, W., Obermueller, S., Palmeri, S., Patel, R., Paul, T., Phiambolis, T., Piana, R., Polansky, B., Polinski, W., Ponce, G., Ribeiro, P., Roccario, E., Rogers, C. P., Rogers, W., Rosenblatt, A., Runyon, J. P., Scheel, F., Schmidt, P., Schneider, R., Schwartz, H., Shelhamer, L., Sheridan, F., Shine, W., Shook, T., Siskind, S., Slama, R., Spear, E., Stouffer, G., Strunk, B., Thadani, U., Timmis, G., Trautloff, R., Tse, A., Wohl, B., Zarren, H., Zucker, R., Kuster, F., and Pardie, J. P.

Subjects
Male, Risk, Infusions, medicine.medical_treatment, Myocardial Infarction, Bolus lytic therapy, Acute myocardial infarction, Tissue plasminogen activator, Thrombolytic drug, Double-Blind Method, Fibrinolytic Agents, medicine, Humans, Thrombolytic Therapy, Myocardial infarction, Infusions, Intravenous, Stroke, Aged, business.industry, ST elevation, Lanoteplase, Emergency department, Middle Aged, medicine.disease, Survival Analysis, Regimen, Relative risk, Anesthesia, Tissue Plasminogen Activator, Female, Intracranial Hemorrhages, Cardiology and Cardiovascular Medicine, business, Intravenous, medicine.drug
Abstract

AIMS To compare the efficacy and safety of lanoteplase, a single-bolus thrombolytic drug derived from alteplase tissue plasminogen activator, with the established accelerated alteplase regimen in patients presenting within 6 h of onset of ST elevation acute myocardial infarction. METHODS AND RESULTS 15,078 patients were recruited from 855 hospitals worldwide and randomized in a 2:1 ratio to receive either lanoteplase 120 KU. kg(-1)as a single intravenous bolus, or up to 100 mg accelerated alteplase given over 90 min. The primary end-point was all-cause mortality at 30 days and the hypothesis was that the two treatments would be equivalent. By 30 days, 6.61% of alteplase-treated patients and 6.75% lanoteplase-treated patients had died (relative risk 1.02). Total stroke occurred in 1.53% alteplase- and 1.87% lanoteplase-treated patients (ns); haemorrhagic stroke rates were 0.64% alteplase and 1.12% lanoteplase (P=0.004). The net clinical deficit of 30-day death or non-fatal disabling stroke was 7.0% and 7.2%, respectively. By 6 months, 8.8% of alteplase-treated patients and 8.7% of lanoteplase-treated patients had died. CONCLUSION Single-bolus weight-adjusted lanoteplase is an effective thrombolytic agent, equivalent to alteplase in terms of its impact on survival and with a comparable risk-benefit profile. The single-bolus regimen should shorten symptoms to treatment times and be especially convenient for emergency department or out-of-hospital administration.

Published
2000

28. Poster Session 3

Author

Fabbri, G. M. T., primary, Baldasseroni, S., additional, Panuccio, D., additional, Zoni Berisso, M., additional, Scherillo, M., additional, Lucci, D., additional, Di Pasquale, G., additional, Mathieu, G., additional, Burazor, I., additional, Burazor, M., additional, Perisic, Z., additional, Atanaskovic, V., additional, Erakovic, V., additional, Stojkovic, A., additional, Vogtmann, T., additional, Schoebel, C., additional, Sogorski, S., additional, Sebert, M., additional, Schaarschmidt, J., additional, Fietze, I., additional, Baumann, G., additional, Penzel, T., additional, Mornos, C., additional, Ionac, A., additional, Cozma, D., additional, Dragulescu, D., additional, Mornos, A., additional, Petrescu, L., additional, Pescariu, L., additional, Brembilla-Perrot, B., additional, Khachab, H., additional, Lamberti, F., additional, Bellini, C., additional, Remoli, R., additional, Cogliandro, T., additional, Nardo, R., additional, Bellusci, F., additional, Mazzuca, V., additional, Gaspardone, A., additional, Aguinaga Arrascue, L. E., additional, Bravo, A., additional, Garcia Freire, P., additional, Gallardo, P., additional, Hasbani, E., additional, Quintana, R., additional, Dantur, J., additional, Inoue, K., additional, Ueoka, A., additional, Tsubakimoto, Y., additional, Sakatani, T., additional, Matsuo, A., additional, Fujita, H., additional, Kitamura, M., additional, Wegrzynowska, M., additional, Konduracka, E., additional, Pietrucha, A. Z., additional, Mroczek-Czernecka, D., additional, Paradowski, A., additional, Bzukala, I., additional, Nessler, J., additional, Igawa, O., additional, Adachi, M., additional, Atarashi, H., additional, Kusama, Y., additional, Kodani, E., additional, Okazaki, R., additional, Nakagomi, A., additional, Endoh, Y., additional, Baez-Escudero, J. L., additional, Dave, A. S., additional, Sasaridis, C. M., additional, Valderrabano, M., additional, Tilz, R., additional, Bai, R., additional, Di Biase, L., additional, Gallinghouse, G. J., additional, Gibson, D., additional, Pisapia, A., additional, Wazni, O., additional, Natale, A., additional, Arujuna, A., additional, Karim, R., additional, Rinaldi, A., additional, Cooklin, M., additional, Rhode, K., additional, Razavi, R., additional, O'neill, M., additional, Gill, J., additional, Kusa, S., additional, Komatsu, Y., additional, Kakita, K., additional, Takayama, K., additional, Taniguchi, H., additional, Otomo, K., additional, Iesaka, Y., additional, Ammar, S., additional, Reents, T., additional, Fichtner, S., additional, Wu, J., additional, Zhu, P., additional, Kolb, C., additional, Hessling, G., additional, Deisenhofer, I., additional, Gilbert, G., additional, Mohanty, P., additional, Cunningham, J., additional, Metz, T., additional, Horton, R., additional, Tao, S., additional, Yamauchi, Y., additional, Okada, H., additional, Maeda, S., additional, Obayashi, T., additional, Isobe, M., additional, Chan, J., additional, Johar, S., additional, Wong, T., additional, Markides, V., additional, Hussain, W., additional, Konstantinidou, M., additional, Wissner, E., additional, Fuernkranz, A., additional, Yoshiga, Y., additional, Metzner, A., additional, Kuck, K.- H., additional, Ouyang, F., additional, Kettering, K., additional, Gramley, F., additional, Mollnau, H., additional, Weiss, C., additional, Bardeleben, S., additional, Biasco, L., additional, Scaglione, M., additional, Caponi, D., additional, Di Donna, P., additional, Sergi, D., additional, Cerrato, N., additional, Blandino, A., additional, Gaita, F., additional, Fiala, M., additional, Wichterle, D., additional, Sknouril, L., additional, Bulkova, V., additional, Chovancik, J., additional, Nevralova, R., additional, Pindor, J., additional, Januska, J., additional, Choi, J. I., additional, Ban, J. E., additional, Yasutsugu, N., additional, Park, J. S., additional, Jung, J. S., additional, Lim, H. E., additional, Park, S. W., additional, Kim, Y. H., additional, Kuhne, M., additional, Reichlin, T., additional, Ammann, P., additional, Schaer, B., additional, Osswald, S., additional, Sticherling, C., additional, Ohe, M., additional, Goya, M., additional, Hiroshima, K., additional, Hayashi, K., additional, Makihara, Y., additional, Nagashima, M., additional, Fukunaga, M., additional, An, Y., additional, Dorwarth, U., additional, Schmidt, M., additional, Wankerl, M., additional, Krieg, J., additional, Straube, F., additional, Hoffmann, E., additional, Kathan, S., additional, Defaye, P., additional, Mbaye, A., additional, Cassagneau, R., additional, Gagniere, V., additional, Jacon, P., additional, Pokushalov, E., additional, Romanov, A., additional, Artemenko, S., additional, Shabanov, V., additional, Elesin, D., additional, Stenin, I., additional, Turov, A., additional, Losik, D., additional, Kondo, K., additional, Miake, J., additional, Yano, A., additional, Ogura, K., additional, Kato, M., additional, Shigemasa, C., additional, Sekiguchi, Y., additional, Tada, H., additional, Yoshida, K., additional, Naruse, Y., additional, Yamasaki, H., additional, Igarashi, M., additional, Machino, T., additional, Aonuma, K., additional, Chen, S., additional, Liu, S., additional, Chen, G., additional, Meng, W., additional, Zhang, F., additional, Yan, Y., additional, Sciarra, L., additional, Dottori, S., additional, Lanzillo, C., additional, De Ruvo, E., additional, De Luca, L., additional, Minati, M., additional, Lioy, E., additional, Calo', L., additional, Lin, J., additional, Nie, Z., additional, Zhu, M., additional, Wang, X., additional, Zhao, J., additional, Hu, W., additional, Tao, H., additional, Ge, J., additional, Johansson, B., additional, Houltz, B., additional, Edvardsson, N., additional, Schersten, H., additional, Karlsson, T., additional, Wandt, B., additional, Berglin, E., additional, Hoyt, R. H., additional, Jenson, B. P., additional, Trines, S. A. I. P., additional, Braun, J., additional, Tjon Joek Tjien, A., additional, Zeppenfeld, K., additional, Tavilla, G., additional, Klautz, R. J. M., additional, Schalij, M. J., additional, Krausova, R., additional, Cihak, R., additional, Peichl, P., additional, Kautzner, J., additional, Pirk, J., additional, Skalsky, I., additional, Maly, J., additional, Imai, K., additional, Sueda, T., additional, Orihashi, K., additional, Picarra, B. C., additional, Santos, A. R., additional, Dionisio, P., additional, Semedo, P., additional, Matos, R., additional, Leitao, M., additional, Banha, M., additional, Trinca, M., additional, Elder, D. H. J., additional, George, J., additional, Jain, R., additional, Lang, C. C., additional, Choy, A. M., additional, Konert, M., additional, Loescher, S., additional, Hartmann, A., additional, Aversa, E., additional, Chirife, R., additional, Sztyglic, E., additional, Mazzetti, H., additional, Mascheroni, O., additional, Tentori, M. C., additional, Pop, R. M., additional, Margulescu, A. D., additional, Dulgheru, R., additional, Enescu, O., additional, Siliste, C., additional, Vinereanu, D., additional, Menezes Junior, A., additional, Castro Carneiro, A. R., additional, De Oliveira, B. L., additional, Shah, A. N., additional, Kantharia, B., additional, De Lucia, R., additional, Soldati, E., additional, Segreti, L., additional, Di Cori, A., additional, Zucchelli, G., additional, Viani, S., additional, Paperini, L., additional, Bongiorni, M. G., additional, Kutarski, A., additional, Czajkowski, M., additional, Pietura, R., additional, Malecka, B., additional, Heintze, J., additional, Eckardt, L., additional, Bauer, A., additional, Meine, M., additional, Van Erven, L., additional, Bloch Thomsen, P. E., additional, Lopez Chicharro, M. P., additional, Merhi, O., additional, Soga, Y., additional, Andou, K., additional, Nobuyoshi, M., additional, Gonzalez-Mansilla, A., additional, Martin-Asenjo, R., additional, Unzue, L., additional, Torres, J., additional, Garralda, E., additional, Coma, R. R., additional, Rodriguez Garcia, J. E., additional, Yaegashi, T., additional, Furusho, H., additional, Kato, T., additional, Chikata, A., additional, Takashima, S., additional, Usui, S., additional, Takamura, M., additional, Kaneko, S., additional, Chudzik, M., additional, Mitkowski, P., additional, Przybylski, A., additional, Lewek, J., additional, Smukowski, T., additional, Maciag, A., additional, Castrejon Castrejon, S., additional, Perez-Silva, A., additional, Estrada, A., additional, Doiny, D., additional, Ortega, M., additional, Lopez-Sendon, J. L., additional, Merino, J. L., additional, O'mahony, C., additional, Coats, C., additional, Cardona, M., additional, Garcia, A., additional, Calcagnino, M., additional, Lachmann, R., additional, Hughes, D., additional, Elliott, P. M., additional, Conti, S., additional, Pruiti, G. P., additional, Puzzangara, E., additional, Romano, S. A., additional, Di Grazia, A., additional, Ussia, G. P., additional, Tamburino, C., additional, Calvi, V., additional, Radinovic, A., additional, Sala, S., additional, Latib, A., additional, Mussardo, M., additional, Sora, S., additional, Paglino, G., additional, Gullace, M., additional, Colombo, A., additional, Ohlow, M.- A. G., additional, Lauer, B., additional, Wagner, A., additional, Schreiber, M., additional, Buchter, B., additional, Farah, A., additional, Fuhrmann, J. T., additional, Geller, J. C., additional, Nascimento Cardoso, R. M., additional, Batista Sa, L. A., additional, Campos Filho, L. F. C., additional, Rodrigues, S. V., additional, Dutra, M. V. F., additional, Borges, T. R. S. A., additional, Portilho, D. R., additional, Deering, T., additional, Bernardes, A., additional, Veiga, A., additional, Gartenlaub, O., additional, Goncalves, A., additional, Jimenez, A., additional, Rousseauplasse, A., additional, Deharo, J. C., additional, Striekwold, H., additional, Gosselin, G., additional, Sitbon, H., additional, Martins, V., additional, Molon, G., additional, Ayala-Paredes, F., additional, Sancho-Tello, M. J., additional, Fazal, I. A., additional, Brady, S., additional, Cronin, J., additional, Mcnally, S., additional, Tynan, M., additional, Plummer, C. J., additional, Mccomb, J. M., additional, Val-Mejias, J. E., additional, Oliveira, R. M., additional, Costa, R., additional, Martinelli Filho, M., additional, Silva, K. R., additional, Menezes, L. M., additional, Tamaki, W. T., additional, Mathias, W., additional, Stolf, N. A. G., additional, Misawa, T., additional, Ohta, I., additional, Shishido, T., additional, Miyasita, T., additional, Miyamoto, T., additional, Nitobe, J., additional, Watanabe, T., additional, Kubota, I., additional, Thibault, B., additional, Ducharme, A., additional, Simpson, C., additional, Stuglin, C., additional, Gagne, C. E., additional, Williams, R., additional, Mcnicoll, S., additional, Silvetti, M. S., additional, Drago, F., additional, Penela, D., additional, Bijnens, B., additional, Doltra, A., additional, Silva, E., additional, Berruezo, A., additional, Mont, L., additional, Sitges, M., additional, Mcintosh, R., additional, Baumann, O., additional, Raju, P., additional, Gurunathan, S., additional, Furniss, S., additional, Patel, N., additional, Sulke, N., additional, Lloyd, G., additional, Mor, M., additional, Dror, S., additional, Tsadok, Y., additional, Bachner-Hinenzon, N., additional, Katz, A., additional, Liel-Cohen, N., additional, Etzion, Y., additional, Mlynarski, R., additional, Mlynarska, A., additional, Wilczek, J., additional, Sosnowski, M., additional, Sinha, A. M., additional, Sinha, D., additional, Noelker, G., additional, Brachmann, J., additional, Weidemann, F., additional, Ertl, G., additional, Jones, M., additional, Searle, N., additional, Cocker, M., additional, Ilsley, E., additional, Foley, P., additional, Khiani, R., additional, Nelson, K. E., additional, Turley, A. J., additional, Owens, W. A., additional, James, S. A., additional, Linker, N. 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H., additional, Hero, M., additional, Mizobuchi, M., additional, Enjoji, Y., additional, Yazaki, Y., additional, Shibata, K., additional, Funatsu, A., additional, Kobayashi, T., additional, Nakamura, S., additional, Amit, G., additional, Pertzov, B., additional, Zahger, D., additional, Medesani, L., additional, Rana, R., additional, Albano, F., additional, Fraguas, H., additional, Pedersen, S. S., additional, Hoogwegt, M. T., additional, Theuns, D. A. M. J., additional, Van Den Broek, K. C., additional, Tekle, F. B., additional, Habibovic, M., additional, Alings, M., additional, Van Der Voort, P., additional, Denollet, J., additional, Vrazic, H., additional, Jilek, C., additional, Lesevic, H., additional, Tzeis, S., additional, Semmler, V., additional, Gold, M. R., additional, Burke, M. C., additional, Bardy, G. H., additional, Varma, N., additional, Pavri, B., additional, Stambler, B., additional, Michalski, J., additional, Investigators, T. R. U. S. 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X., additional, Mutch, E., additional, Brashaw-Smith, J., additional, Ball, L., additional, Leyva, F., additional, Kim, D. H., additional, Lee, M. J., additional, Lee, W. S., additional, Park, S. D., additional, Shin, S. H., additional, Woo, S. I., additional, Kwan, J., additional, Park, K. S., additional, Munetsugu, Y., additional, Tanno, K., additional, Kikuchi, M., additional, Ito, H., additional, Miyoshi, F., additional, Kawamura, M., additional, Kobayashi, Y., additional, Man, S., additional, Algra, A. M., additional, Schreurs, C. A., additional, Van Der Wall, E. E., additional, Cannegieter, S. C., additional, Swenne, C. A., additional, Iitsuka, K., additional, Kondo, T., additional, Goebbert, K., additional, Karossiene, Z., additional, Goldman, D., additional, Kallen, B., additional, Kerpi, E., additional, Sardo, J., additional, Arsenos, P., additional, Gatzoulis, K., additional, Manis, G., additional, Dilaveris, P., additional, Tsiachris, D., additional, Mytas, D., additional, Asimakopoulos, S., additional, Stefanadis, C., additional, Sideris, S., additional, Kartsagoulis, E., additional, Barbosa, O., additional, Marocolo Junior, M., additional, Silva Cortes, R., additional, Moraes Brandolis, R. A., additional, Oliveira, L. F., additional, Pertili Rodrigues De Resende, L. A., additional, Vieira Da Silva, M. A., additional, Dias Da Silva, V. J., additional, Hegazy, R. A., additional, Sharaf, I. A., additional, Fadel, F., additional, Bazaraa, H., additional, Esam, R., additional, Deshko, M. S., additional, Snezhitsky, V. A., additional, Stempen, T. P., additional, Kuroki, K., additional, Igawa, M., additional, Kuga, K., additional, Ferreira Santos, L., additional, Dionisio, T., additional, Nunes, L., additional, Machado, J., additional, Castedo, S., additional, Henriques, C., additional, Matos, A., additional, Oliveira Santos, J., additional, Kraaier, K., additional, Olimulder, M. A. G. M., additional, Galjee, M. A., additional, Van Dessel, P. F. H. M., additional, Van Der Palen, J., additional, Wilde, A. A. M., additional, Scholten, M. F., additional, Chouchou, F., additional, Poupard, L., additional, Philippe, C., additional, Court-Fortune, I., additional, Barthelemy, J.- C., additional, Roche, F., additional, Dolgoshey, T. S., additional, Madekina, G. 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2011
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29. Poster Session 1

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Deshmukh, A., primary, Sharma, S. S., additional, Gobal, F. G., additional, Singla, S. S., additional, Hebbar, P. H., additional, Paydak, H. P., additional, Igarashi, M., additional, Tada, H., additional, Sekiguchi, Y., additional, Yamasaki, H., additional, Kuroki, K., additional, Machino, T., additional, Yoshida, K., additional, Aonuma, K., additional, Shavadia, J., additional, Otieno, H., additional, Yonga, G., additional, Jinah, A., additional, Qvist, J. F., additional, Soerensen, P. H., additional, Dixen, U., additional, Ramirez-Marrero, M. A., additional, Perez-Villardon, B., additional, Gaitan-Roman, D., additional, Jimenez-Navarro, M., additional, Delgado-Prieto, J. L., additional, De Teresa-Galvan, E., additional, De Mora-Martin, M., additional, Deshmukh, A., additional, Hebbar, P. B., additional, Wei, W. X., additional, Bardari, S., additional, Zecchin, M., additional, Salame', R., additional, Vitali Serdoz, L., additional, Di Lenarda, A., additional, Guerrini, N., additional, Barbati, G., additional, Sinagra, G., additional, Hanazawa, K., additional, Kaitani, K., additional, Nakagawa, Y., additional, Lenaerts, I., additional, Driesen, R., additional, Hermida, N., additional, Heidbuchel, H., additional, Janssens, S., additional, Balligand, J. L., additional, Sipido, K. R., additional, Willems, R., additional, Sehra, R., additional, Krummen, D., additional, Briggs, C., additional, Narayan, S., additional, Tanaka, Y., additional, Hirao, K., additional, Nakamura, T., additional, Inaba, O., additional, Yagishita, A., additional, Higuchi, K., additional, Hachiya, H., additional, Isobe, M., additional, Kallergis, E., additional, Kanoupakis, E. M., additional, Mavrakis, H. E., additional, Goudis, C. A., additional, Maliaraki, N. E., additional, Vardas, P. E., additional, Kiuchi, K., additional, Piorkowski, C., additional, Kircher, S., additional, Gaspar, T., additional, Watanabe, N., additional, Bollmann, A., additional, Hindricks, G., additional, Wauters, K., additional, Grosse, A., additional, Raffa, S., additional, Brunelli, M., additional, Geller, J. C., additional, Maggioni, A. P., additional, Gonzini, L., additional, Gussoni, G., additional, Vescovo, G., additional, Gulizia, M., additional, Pirelli, S., additional, Mathieu, G., additional, Di Pasquale, G., additional, Salame, R., additional, Magnani, S., additional, Sakamoto, T., additional, Kumagai, K., additional, Fuke, E., additional, Nishiuchi, S., additional, Hayashi, T., additional, Miki, Y., additional, Naito, S., additional, Oshima, S., additional, Hof, I. E., additional, Vonken, E., additional, Velthuis, B. K., additional, Meine, M., additional, Hauer, R. N. W., additional, Loh, K. P., additional, Na, J. O., additional, Choi, C. U., additional, Kim, E. J., additional, Rha, S. W., additional, Park, C. G., additional, Seo, H. S., additional, Oh, D. J., additional, Lim, H. E., additional, Wichterle, D., additional, Bulkova, V., additional, Fiala, M., additional, Chovancik, J., additional, Simek, J., additional, Peichl, P., additional, Cihak, R., additional, Kautzner, J., additional, Glick, A., additional, Viskin, S., additional, Belhassen, B., additional, Navarrete, A., additional, Conte, F., additional, Ishti, A., additional, Sai, D., additional, Moran, M., additional, Chitovova, Z., additional, Ahmed, H., additional, Mares, K., additional, Skoda, J., additional, Sediva, L., additional, Petru, J., additional, Reddy, V. 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R., additional, Del Rosso, A., additional, Guarnaccia, V., additional, Zipoli, A., additional, Rabajoli, F., additional, Foglia Manzillo, G., additional, Tolardo, C., additional, Checchinato, C., additional, Chiaravallotti, S., additional, Santarone, M., additional, Spinnler, M. T., additional, Podoleanu, C., additional, Frigy, A., additional, Dobreanu, D., additional, Ginghina, C., additional, and Carasca, E., additional

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2011
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33. Poster session 4

Author

Parisi, V, Ferro, G, Bevilacqua, A, Caruso, A, Grimaldi, G, Rengo, G, Leosco, D, Ferrara, N, Yan, B P Y, Lai, KH, Chan, MYT, Lam, DYY, Fong, KNY, Chau, C, Fok, MHL, Kam, K, Tam, GM, Lee, PW, Takeuchi, H, Angelis, A, Aggeli, K, Ioakeimidis, N, Felekos, I, Abdelrasoul, M, Aznaouridis, K, Rokas, K, Vlachopoulos, C, Tousoulis, D, Cano Carrizal, R, Casanova Rodriguez, C, Prieto Moriche, E, Iglesias Del Valle, D, Cadenas Chamorro, R, De Juan Baguda, J, Martin-Penato Molina, A, Paredes Gonzalez, B, Garcia Garcia, A, Plaza Perez, I, Caiani, EG, Arbeille, P, Massabuau, P, Colombo, F, Ferri, G, Kasswat, C, Medvedofsky, D, Lang, RM, Vaida, P, Kuznetsov, VA, Yaroslavskaya, EI, Krinochkin, DV, Pushkarev, GS, Gorbatenko, EA, Bruno, RM, Bianchini, E, Di Lascio, N, Stea, F, Ujka, K, Marabotti, A, D’angelo, GS, Ghiadoni, L, Pratali, L, Zemedkun, M, Wang, Z, Asch, FM, Niki, K, Sugawara, M, Yauchi, S, Inoue, K, Yagawa, M, Takamisawa, I, Umemura, J, Yoshikawa, T, Sumiyoshi, T, Tomoike, H, Christov, G, Saundankar, J, Perdreau, E, Mukasa, T, Shah, V, Klein, N, Brogan, P, Marek, J, Batalli, A, Ibrahimi, P, Ahmeti, A, Haliti, E, Bytyci, I, Poniku, A, Henein, MY, Bajraktari, G, Luo, XX, Fang, F, Gan, SF, Ma, Z, Yu, CM, Gonella, A, Conte, E, Morena, L, Riva, L, Civelli, D, Losardo, L, Canepari, ME, Castellino, C, Grasso, M, Margaria, F, Massoure, P L, Camus, O, Gabaudan, C, Desmots, F, Fourcade, L, Jacquier, A, Divchev, D, Weippert, M, Schmidt, P, Gettel, H, Neugebauer, A, Behrens, K, Braumann, K-M, Wolfarth, B, Nienaber, CA, Rodriguez Gonzalez, E, Monivas Palomero, V, Mingo Santos, S, Restrepo Cordoba, MA, Goirigolzarri Artaza, J, Gomez Bueno, M, Garcia Izquierdo, E, Serrano Fiz, S, Gonzalez Roman, A, Segovia Cubero, J, Pila-On, SASTRA, Atmadikoesoemah, C, Soesanto, A, Andriantoro, H, Kowallick, J T, Morton, G, Lamata, P, Jogiya, R, Kutty, S, Lotz, J, Hasenfuss, G, Nagel, E, Chiribiri, A, Schuster, A, Jung, IH, Moon, JG, Byun, YS, Kim, TH, Park, SH, Seo, HS, Wellnhofer, E, Kriatselis, C, Gerds-Li, JH, Kropf, M, Pieske, B, Graefe, M, Eldeep, M, Marghany, K, Mokarrab, M, Albaz, M, Marcos-Alberca Moreno, P, Perez-Isla, L, Palacios, J, Gomez De Diego, JJ, De Agustin, JA, Luaces, M, Mahia, P, Arrazola, J, Garcia-Fernandez, MA, Macaya, C, Attenhofer Jost, C H, Mueller, P, Naegeli, B, Levis, P, Amann, FW, Seifert, B, Maurer, D, Bertel, O, Caspar, T, Samet, H, Jesel, L, Petit-Eisenmann, H, Trinh, A, Talha, S, Morel, O, Ohlmann, P, Leao, S, Cordeiro, F, Magalhaes, P, Moz, M, Trigo, J, Mateus, P, Fontes, P, Moreira, I, Sharif, D, Matanis, W, Sharif-Rasslan, A, Sharif, Y, Rosenschein, U, Faustino, M, Bravo Baptista, S, Freitas, A, Bicho Augusto, J, Leal, P, Nedio, M, Antunes, C, Farto E Abreu, P, Gil, V, Morais, C, Nguyen, VT, Cimadevilla, C, Arangalage, D, Dehoux, M, Dreyfus, J, Codogno, I, Duval, X, Huart, V, Vahanian, A, Messika-Zeitoun, D, Cakmak, HA, Aslan, S, Erturk, M, Ornek, V, Tosu, AR, Kalkan, AK, Ozturk, D, Tasbulak, O, Avci, Y, Gul, M, Cioffi, G, Mazzone, C, Di Nora, C, Barbati, G, Ognibene, F, Nistri, S, Tarantini, L, Pulignano, G, Di Lenarda, A, Faggiano, P, Nishimura, S, Izumi, C, Amano, M, Miyake, M, Tamura, T, Kondo, H, Kaitani, K, Nakagawa, Y, Rosa, I, Ancona, F, Stella, S, Marini, C, Spartera, M, Barletta, M, Pavon, AG, Margonato, A, Agricola, E, Arangalage, D, Nguyen, V, Robert, T, Melissopoulou, M, Mathieu, T, Codogno, I, Cimadevilla, C, Dehoux, M, Vahanian, A, Messika-Zeitoun, D, Rahman, MT, Zito, C, Longobardo, L, Cusma Piccione, M, Zucco, M, D'angelo, M, Rivetti, L, Carerj, ML, Boretti, I, Calabro, MP, Carerj, S, Lozano Granero, VC, Rodriguez Munoz, D, Carbonell San Roman, A, Moya Mur, JL, Hinojar, R, Gonzalez, A, Casas, E, Jimenez Nacher, JJ, Fernandez-Golfin, C, Zamorano Gomez, JL, Gripari, P, Tamborini, G, Muratori, M, Ghulam Ali, S, Fusini, L, Alamanni, F, Pepi, M, Keramida, K, Bellamy, M, Dawson, D, Nihoyannopoulos, P, Solowjowa, N, Musayeva, L, Hrytsyna, Y, Knosalla, CH, Falk, V, Muraru, D, Maddalozzo, A, Jenei, C, Dequal, D, Veronesi, F, Aruta, P, Romeo, G, Iliceto, S, Badano, L, Gursoy, MO, Kalcik, M, Ozkan, M, Astarcioglu, MA, Gokdeniz, T, Yesin, M, Karakoyun, S, Gunduz, S, Tuncer, MA, Koksal, C, Cresti, A, Chiavarelli, M, Guerrini, F, D'aiello, N, Albano, A, De Sensi, F, Picchi, A, Cesareo, F, Severi, S, Braga, M, Nascimento, H, Flores, L, Ribeiro, V, Melao, F, Dias, P, Maciel, MJ, Bettencourt, P, Ferreiro Quero, C, Delgado Ortega, M, Puentes Chiachio, M, Mesa Rubio, M D, Ruiz Ortiz, M, Duran Jimenez, E, Sanchez Fernandez, J, Morenate Navio, C, Pan, M, Suarez De Lezo, J, Jansen, R, Agostoni, P, Stella, PR, Nijhoff, F, Ramjankhan, FZ, Suyker, WJ, Chamuleau, SAJ, Scislo, P, Huczek, Z, Kochman, J, Rymuza, B, Kochanowski, J, Scisbisz, A, Piatkowski, R, Opolski, G, Ray, R, Knott, K, Smith, D, Rodriguez, A, Finocchiaro, G, Sharma, R, Veiga, C, Calvo Iglesias, F, Paredes-Galan, E, Pazos, Pablo, Romo, Andres Iniguez, Ageing, Disease, Cardiovascular, Krejci, J, Hude, P, Ozabalova, E, Zampachova, V, Mlejnek, D, Sochorova, D, Spinarova, L, Wess, G, Klueser, L, Holler, PJ, Simak, J, Kuechenhoff, H, Vago, H, Czimbalmos, CS, Toth, A, Csecs, I, Kecskes, K, Suhai, F, Kiss, O, Simor, T, Becker, D, Merkely, B, Hinojar, R, Fernandez-Golfin, C, Portugal, JC, Esteban, A, Megias, A, Ruiz Leria, S, Rincon, LM, Jimenez-Nacher, JJ, Zamorano, JL, Dejgaard, LA, Haland, T, Lie, OH, Massey, R, Edvardsen, T, Haugaa, KH, Pavlyukova, EN, Evtushenko, VA, Smushlyaev, KA, Karpov, RS, Zaroui, A, Asmi, MONIA, Ben Said, RYM, Zidi, WIEM, Wali, SANA, Feki, M, Mourali, MS, Kaabachi, NEZIHZ, Mechmeche, RACHID, Labarre, Q, Garcia, R, Degand, B, Christiaens, L, Coisne, D, Csecs, I, Czimbalmos, CS, Toth, A, Suhai, F I, Pozsonyi, Z, Becker, D, Simor, T, Merkely, B, Vago, H, Maceira Gonzalez, A M, Tuset, L, Ripoll, C, Cosin-Sales, J, Igual, B, Salazar, J, Belloch, V, Coisne, D, Viera, F, Labarre, Q, Garcia, R, Degand, B, Christiaens, L, Rodriguez Gonzalez, E, Monivas Palomero, V, Mingo Santos, S, Restrepo Cordoba, MA, Goirigolzarri Artaza, J, Gomez Bueno, M, Serrano Fiz, S, Gonzalez Roman, A, Garcia Izquierdo Jaen, E, Segovia Cubero, J, Rojek, A, Chrostowska, M, Dudziak, M, Narkiewicz, K, Grapsa, J, Tan, TC, Dawson, D, Nihoyannopoulos, P, Methia, N, Cioffi, G, Viapiana, O, Ognibeni, F, Dalbeni, A, Gatti, D, Di Nora, C, Mazzone, C, Faganello, G, Di Lenarda, A, Rossini, M, Styczynski, G, Milewska, A, Marczewska, M, Sobieraj, P, Sobczynska, M, Dabrowski, M, Kuch-Wocial, A, Szmigielski, C A, Czimbalmos, C, Vago, H, Csecs, I, Toth, A, Suhai, F I, Kiss, O, Sydo, N, Becker, D, Simor, T, Merkely, B, Konopka, M, Burkhard-Jagodzinska, K, Krol, W, Jakubiak, A, Aniol-Strzyzewska, K, Sitkowski, D, Dluzniewski, M, Braksator, W, Sturmberger, T, Eder, V, Ebner, C, Winter, S, Martinek, M, Puererfellner, H, Aichinger, J, Sormani, P, Rusconi, C, Zancanella, M, Peritore, A, De Chiara, B, Spano’, F, Vallerio, P, Cairoli, R, Giannattasio, C, Moreo, A, Siliste, RN, Chitroceanu, A, Ianula, R, Spataru, D, Isacoff, D, Rodrigues, AC, Monaco, C, Guimaraes, L, Cordovil, R, Piveta, R, Franca, L, Fischer, CH, Vieira, M, Lira, E, Morhy, S, Antonielli, E, Pizzuti, A, Dogliani, S, Mabritto, B, Bassignana, A, Pancaldo, D, Doronzo, B, Evdoridis, C, Papasaikas, D, Sergi, E, Papadimitriou, D, Tolios, P, Papagiannis, G, Tzamou, V, Trikas, A, Scali, MC, Bombardini, T, Picano, E, Scali, MC, Bombardini, T, Salvadori, S, Costantino, MF, Picano, E, Scali, MC, Bombardini, T, Salvadori, S, Picano, E, Generati, G, Bandera, F, Pellegrino, M, Labate, V, Carbone, F, Alfonzetti, E, Guazzi, M, Rivetti, L, Cusma Piccione, M, Zito, C, D'angelo, M, Manganaro, R, Pizzino, F, Terrizzi, A, Quattrocchi, S, Ioppolo, A, Carerj, S, Giga, V, Boskovic, N, Stepanovic, J, Beleslin, B, Nedeljkovic, I, Dobric, M, Djordjevic-Dikic, A, Popovic, D, Petrovic, I, Banovic, M, Lasica, R, Pesic, V, Plecas - Solarovic, B, Vidojevic, D, Djordjevic, T, Orovic, M, Vujisic - Tesic, B, Bordonaro, V, Buccheri, S, Bottari, VE, Romano, C, Atanasio, FA, Tamburino, C, Monte, I P, Korchi, F, Kassongo, A, Meimoun, P, De Zuttere, D, Lardoux, HERVE, Zoppellaro, G, Venneri, L, Khattar, RS, Li, W, Senior, R, Casanova Rodriguez, C, Cano Carrizal, R, Cadenas Chamorro, R, Iglesias Del Valle, D, Prieto Moriche, E, Garcia Garcia, A, Martin Penato Molina, A, De Juan Baguda, J, Paredes Gonzalez, B, Plaza Perez, I, Sreekumar, P, Manjunath, CN, Ravindranath, KS, Dhanalakshmi, CD, Ranjbar, S, Karvandi, M, Ranjbar, F, Ghaffaripour Jahromi, M, Hassantash, SA, Foroughi, M, Maurea, N, Coppola, C, Piscopo, G, Galletta, F, Maurea, C, Esposito, E, Barbieri, A, Riccio, G, De Laurentiis, M, De Lorenzo, C, Strachinaru, M, De Jong, N, Geleijnse, ML, Van Dalen, BM, Vos, HJ, Keramida, K, Kouris, N, Dawson, D, Olympios, CD, Nihoyannopoulos, P, Rodriguez Munoz, D, Carbonell San Roman, A, Lozano Granero, C, Moya Mur, JL, Fernandez-Golfin, C, Moreno Planas, J, Casas Rojo, E, Fernandez Santos, S, Hernandez-Madrid, A, Zamorano Gomez, JL, D'auria, F, Leone, R, Itri, F, Del Negro, G, Colombino, M, Masiello, P, Longobardi, A, Rosapepe, F, Iesu, S, Di Benedetto, G, Capotosto, L, D'orazio, S, Ashurov, R, Continanza, G, Mangieri, E, Terzano, C, Vitarelli, A, Seo, J, Cho, IJ, Chang, HJ, Hong, GR, Ha, JW, Chung, NS, Shim, CY, Bianco, F, Cicchitti, V, Radico, F, Conti, M, Bucciarelli, V, Marchetti, M, Tonti, G, De Caterina, R, Di Girolamo, E, Gallina, S, Plokhova, EV, Akasheva, D, Tkacheva, O, Strazhesko, I, Dudinskaya, E, Pokshubina, I, Pykhtina, V, Kruglikova, A, Brailova, N, Boytsov, S, Weng, K-P, Lin, CC, Wahba Hassanein, M, Ashour, Z A, Bakhoum, S W G, Abdel Wahab, A M A, Hussein, EKHLAS, Saad, ZIZI, Malik, RAUOOF, Almasswary, ADEL, Elrawy, M, Lo Iudice, F, Lembo, M, Muscariello, R, Carlomagno, F, Pivonello, R, Colao, A, Trimarco, B, Galderisi, M, Purwowiyoto, S L, Santoso, A, Soesanto, A M, Indonesia), PERKI (Perhimpunan Dokter Spesialis Kardiovaskular, Segura De La Cal, T, Moya Mur, JL, Garcia Martin, A, Carbonell, S, Fraile Sanz, C, Rincon, LM, Rodriguez Munoz, DA, Jimenez Nacher, JJ, Fernandez-Golfin, C, Zamorano, JL, Ongun, A, Habibova, U, Gerede, DM, Dincer, I, Kilickap, M, Erol, C, Nouhravesh, N, Andersen, HU, Jensen, JS, Rossing, P, Jensen, MT, Gasior, Z, Dabek, J, Balys, M, Glogowska-Rygus, J, and Pysz, P

Abstract

Purpose: Epicardial adipose tissue (EAT) thickness, measured by echocardiography, is associated to the presence of coronary artery disease (CAD) and severe aortic stenosis (AS). EAT thickness is commonly referred as the diameter of the echo-free space between the right ventricular wall and the visceral layer of the pericardium in parasternal long axis view, using the aortic annulus as an anatomic landmark (EAT-1). We aimed to demonstrate that the direct measurement of the adipose tissue thickness visualized in the space between the ascending aorta and the right ventricle (EAT-2) might be considered an alternative method. Methods: We measured EAT-1 and EAT-2 in 130 pts with severe cardiac disease referred for cardiac surgery: 53 pts with isolated AS, 49 pts with severe CAD, and 28 pts with both severe AS and CAD (AS+CAD); and in 50 control subjects matched for age, sex and BMI. The two measurements were obtained at end-systole in 3 cardiac cycles (figure). Results. Both EAT-1 and EAT-2 measurements had an excellent reproducibility. With respect to controls pts had significantly increased EAT-1 (2,4 ± 0,5mm vs 6 ± 2mm; p<0,05) and EAT-2 (3 ± 1,2mm vs 12 ± 3mm; p<0,05). EAT-1 and EAT-2 were not statistically different in controls. EAT-2 was significantly higher than EAT-1 in CAD, AS, and AS+CAD pts (p<0,05). Interestingly, EAT-2, but not EAT-1, was significantly increased in AS+CAD pts with respect to EAT-2 of pts with isolated AS and isolated CAD. Conclusions: Our data demonstrate that EAT-2, as well as EAT-1, is a valuable method to measure EAT thickness. Further, EAT-2 seems to better recognize EAT increase, in pts with AS+CAD. Comprehensively, EAT-2 is greater than EAT-1. The larger space between ascending aorta and right ventricle, allowing EAT expansion, could justify our observation.

Published
2015
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36. Poster session 4: Friday 5 December 2014, 08:30-12:30 * Location: Poster area

Author

Orii, M, Tanimoto, T, Yokoyama, M, Ota, S, Kubo, T, Hirata, K, Tanaka, A, Imanishi, T, Akasaka, T, Michelsen, MM, Pena, A, Mygind, ND, Hoest, NB, Prescott, E, Abd El Dayem, SOHA, Battah, AHMED, Abd El Azzez, FATEN, Ahmed, AZZA, Fattoh, AYA, Ismail, REEM, Andjelkovic, K, Kalimanovska Ostric, D, Nedeljkovic, I, Andjelkovic, I, Rashid, HESHAM, Abuel Enien, HESHAM, Ibraheem, MAHER, work, Tissue Doppler echocardiography research, Vago, H, Toth, A, Csecs, I, Czimbalmos, CS, Suhai, F I, Kecskes, K, Becker, D, Simor, T, Merkely, B, D'ascenzi, F, Pelliccia, A, Natali, BM, Cameli, M, Lisi, M, Focardi, M, Corrado, D, Bonifazi, M, Mondillo, S, Zaha, VG, Kim, GE, Su, KN, Zhang, J, Mikush, N, Ross, J, Palmeri, M, Young, LH, Tadic, M, Ilic, SI, Celic, VC, Jaimes, C, Gonzalez Mirelis, J, Gallego, M, Goirigolzarri, J, Pellegrinet, M, Poli, S, Prati, G, Vriz, O, Di Bello, V, Carerj, S, Zito, C, Mateescu, A, Popescu, BA, Antonini-Canterin, F, Chatzistamatiou, E, Moustakas, G, Memo, G, Konstantinidis, D, Mpampatzeva Vagena, I, Manakos, K, Traxanas, K, Vergi, N, Feretou, A, Kallikazaros, I, Hewing, B, Theres, L, Dreger, H, Spethmann, S, Stangl, K, Baumann, G, Knebel, F, Uejima, T, Itatani, K, Nakatani, S, Lancellotti, P, Seo, Y, Zamorano, JL, Ohte, N, Takenaka, K, group, VFM international collaboration, Naar, J, Mortensen, L, Johnson, J, Winter, R, Shahgaldi, K, Manouras, A, Braunschweig, F, Stahlberg, M, Coisne, D, Al Arnaout, A-M, Tchepkou, C, Raud Raynier, P, Diakov, C, Degand, B, Christiaens, L, Barbier, P, Mirea, O, Cefalu, C, Savioli, G, Guglielmo, M, Maltagliati, A, O'neill, L, Walsh, K, Hogan, J, Manzoor, T, Ahern, B, Owens, P, Savioli, G, Guglielmo, M, Mirea, O, Cefalu, C, Barbier, P, Sengelov, M, Biering-Sorensen, T, Jorgensen, PG, Bruun, NE, Fritz-Hansen, T, Bech, J, Olsen, FJ, Sivertsen, J, Jensen, JS, Marta, L, Abecasis, J, Reis, C, Ribeiras, R, Andrade, MJ, Mendes, M, D'andrea, A, Stanziola, A, Di Palma, E, Martino, M, Lanza, M, Betancourt, V, Maglione, M, Calabro', R, Russo, MG, Bossone, E, Vogt, M O, Meierhofer, CH, Rutz, TH, Fratz, S, Ewert, P, Roehlig, CH, Kuehn, A, Storsten, P, Eriksen, M, Remme, EW, Boe, E, Smiseth, OA, Skulstad, H, Ereminiene, E, Ordiene, R, Ivanauskas, V, Vaskelyte, J, Stoskute, N, Kazakauskaite, E, Benetis, R, Marketou, M, Parthenakis, F, Kontaraki, J, Zacharis, E, Maragkoudakis, S, Logakis, J, Roufas, K, Vougia, D, Vardas, P, Dado, E, Dado, E, Knuti, G, Djamandi, J, Shota, E, Sharka, I, Saka, J, Halmai, L, Nemes, A, Kardos, A, Neubauer, S, Kurnicka, K, Domienik-Karlowicz, J, Lichodziejewska, B, Goliszek, S, Grudzka, K, Krupa, M, Dzikowska-Diduch, O, Ciurzynski, M, Pruszczyk, P, Chung, H, Kim, JY, Yoon, YW, Min, PK, Lee, BK, Hong, BK, Rim, SJ, Kwon, HM, Choi, EY, Soya, OV, Kuryata, OV, Kakihara, R, Naruse, C, Inayoshi, A, El Sebaie, MAHA, Frer, ABDEL, Abdelsamie, MAGDY, Eldamanhory, AHMED, Ciampi, Q, Cortigiani, L, Simioniuc, A, Manicardi, C, Villari, B, Picano, E, Sicari, R, Ferferieva, V, Deluyker, D, Lambrichts, I, Rigo, JM, Bito, V, Kuznetsov, VA, Yaroslavskaya, EI, Krinochkin, DV, Pushkarev, GS, Gorbatenko, EA, Trzcinski, P, Michalski, BW, Lipiec, P, Szymczyk, E, Peczek, L, Nawrot, B, Chrzanowski, L, Kasprzak, JD, Todaro, MC, Zito, C, Khandheria, BK, Cusma-Piccione, M, La Carrubba, S, Antonini-Canterin, F, Di Bello, V, Oreto, G, Di Bella, G, Carerj, S, Gunyeli, E, Oliveira Da Silva, C, Sahlen, A, Manouras, A, Winter, R, Shahgaldi, K, Spampinato, RA, Tasca, M, Roche E Silva, JG, Strotdrees, E, Schloma, V, Dmitrieva, Y, Dobrovie, M, Borger, MA, Mohr, FW, Einarsen, E, Cramariuc, D, Lonnebakken, MT, Boman, K, Gohlke-Barwolf, C, Chambers, JB, Gerdts, E, Calin, A, Rosca, M, Beladan, CC, Mirescu Craciun, A, Gurzun, MM, Mateescu, A, Enache, R, Ginghina, C, Popescu, BA, Antova, E, Georgievska Ismail, LJ, Srbinovska, E, Andova, V, Peovska, I, Davceva, J, Otljanska, M, Vavulkis, M, Tsuruta, H, Kohsaka, S, Murata, M, Yasuda, R, Dan, M, Yashima, F, Inohara, T, Maekawa, Y, Hayashida, K, Fukuda, K, Migliore, R, Adaniya, ME, Barranco, MA, Miramont, G, Gonzalez, S, Tamagusuku, H, Abid, L, Ben Kahla, S, Charfeddine, S, Abid, D, Kammoun, S, Amano, M, Izumi, C, Miyake, M, Tamura, T, Kondo, H, Kaitani, K, Nakagawa, Y, Ghulam Ali, S, Fusini, L, Tamborini, G, Muratori, M, Gripari, P, Bottari, V, Celeste, F, Cefalu', C, Alamanni, F, Pepi, M, Obase, K, Mor-Avi, V, Weinert, L, Lang, R, Teixeira, R, Monteiro, R, Garcia, J, Ribeiro, M, Cardim, N, Goncalves, L, Miglioranza, MH, Muraru, D, Cavalli, G, Addetia, K, Cucchini, U, Mihaila, S, Tadic, M, Veronesi, F, Lang, RM, Badano, L, Galian Gay, L, Gonzalez Alujas, MT, Teixido Tura, G, Gutierrez Garcia, L, Rodriguez-Palomares, JF, Evangelista Masip, A, Conte, L, Fabiani, I, Giannini, C, La Carruba, S, De Carlo, M, Barletta, V, Petronio, AS, Di Bello, V, Mahmoud, H, Al-Ghamdi, M, Ghabashi, A, Salaun, E, Zenses, AS, Evin, M, Collart, F, Pibarot, P, Habib, G, Rieu, R, Fabregat Andres, O, Estornell Erill, J, Cubillos-Arango, A, Bochard-Villanueva, B, Chacon-Hernandez, N, Higueras-Ortega, L, Perez-Bosca, L, Paya-Serrano, R, Ridocci-Soriano, F, Cortijo-Gimeno, J, Mzoughi, K, Zairi, I, Jabeur, M, Ben Moussa, F, Mrabet, K, Kamoun, S, Fennira, S, Ben Chaabene, A, Kraiem, S, Schnell, F, Betancur, J, Daudin, M, Simon, A, Lentz, PA, Tavard, F, Hernandes, A, Carre, F, Garreau, M, Donal, E, Abduch, MCD, Vieira, MLC, Antunes, M, Mathias, W, Mady, C, Arteaga, E, Alencar, AM, Tesic, M, Djordjevic-Dikic, A, Beleslin, B, Giga, V, Trifunovic, D, Petrovic, O, Jovanovic, I, Petrovic, M, Stepanovic, J, Vujisic-Tesic, B, Choi, EY, Cha, JJ, Chung, H, Kim, KH, Yoon, YW, Kim, JY, Lee, BK, Hong, BK, Rim, SJ, Kwon, HM, Bergler-Klein, J, Geier, C, Maurer, G, Gyongyosi, M, Cortes Garcia, M, Oliva, MR, Navas, MA, Orejas, M, Rabago, R, Martinez, ME, Briongos, S, Romero, AM, Rey, M, Farre, J, Ruisanchez Villar, C, Ruiz Guerrero, L, Rubio Ruiz, S, Lerena Saenz, P, Gonzalez Vilchez, FJ, Hernandez Hernandez, JL, Armesto Alonso, S, Blanco Alonso, R, Martin Duran, R, Gonzalez-Gay, MA, Novo, G, Marturana, I, Bonomo, V, Arvigo, L, Evola, V, Karfakis, G, Lo Presti, M, Verga, S, Novo, S, Petroni, R, Acitelli, A, Bencivenga, S, Cicconetti, M, Di Mauro, M, Petroni, A, Romano, S, Penco, M, Park, SM, Kim, SA, Kim, MN, Shim, WJ, Tadic, M, Majstorovic, AM, Ivanovic, BI, Celic, VC, Driessen, M M P, Meijboom, FJ, Mertens, L, Dragulescu, A, Friedberg, MK, De Stefano, F, Santoro, C, Buonauro, A, Muscariello, R, Lo Iudice, F, Ierano, P, Esposito, R, Galderisi, M, Sunbul, M, Kivrak, T, Durmus, E, Yildizeli, B, Mutlu, B, Rodrigues, AC, Daminello, E, Echenique, LS, Cordovil, A, Oliveira, W, Monaco, CH, Lira, E, Fischer, CH, Vieira, M, Morhy, S, Mignot, A, Jaussaud, J, Chevalier, L, Lafitte, S, D'ascenzi, F, Cameli, M, Curci, V, Alvino, F, Lisi, M, Focardi, M, Corrado, D, Bonifazi, M, Mondillo, S, Ikonomidis, I, Pavlidis, G, Lambadiari, V, Kousathana, F, Triantafyllidi, H, Varoudi, M, Dimitriadis, G, Lekakis, J, Cho, J S, Cho, EJ, Yoon, HJ, Ihm, SH, Lee, JH, Molnar, A A, Kovacs, A, Apor, A, Tarnoki, AD, Tarnoki, DL, Horvath, T, Maurovich-Horvat, P, Jermendy, GY, Kiss, RG, Merkely, B, Al-Habbaa, A, Petrovic-Nagorni, S, Ciric-Zdravkovic, S, Stanojevic, D, Jankovic-Tomasevic, R, Atanaskovic, V, Mitic, V, Todorovic, L, Dakic, S, Park, J S, Choi, JH, Kim, SH, Choi, JH, Kwon, YS, Jin, HY, Coppola, C, Piscopo, G, Galletta, F, Maurea, C, Esposito, E, Barbieri, A, Maurea, N, Kaldararova, M, Tittel, P, Kantorova, A, Vrsanska, V, Kollarova, E, Hraska, V, Nosal, M, Ondriska, M, Masura, J, Simkova, I, Tadeu, I, Azevedo, O, Lourenco, M, Luis, F, Lourenco, A, Planinc, i, Bagadur, G, Bijnens, B, Ljubas, J, Baricevic, Z, Skoric, B, Velagic, V, Milicic, D, Cikes, M, Campanale, C M, Di Maria, S, Mega, S, Nusca, A, Marullo, F, Di Sciascio, G, El Tahlawi, M, Abdallah, M, Gouda, M, Gad, MARWA, Elawady, M, Igual Munoz, B, Maceira Gonzalez Alicia, AMG, Estornell Erill, JEE, Donate Betolin, LDB, Vazquez Sanchez Alejandro, AVS, Valera Martinez, FVM, Sepulveda- Sanchez, PSS, Cervera Zamora, ACZ, Piquer Gil Marina, MPG, Montero- Argudo, AMA, Naka, KK, Evangelou, D, Lakkas, L, Kalaitzidis, R, Bechlioulis, A, Gkirdis, I, Tzeltzes, G, Nakas, G, Pappas, K, Michalis, LK, Mansencal, N, Bagate, F, Arslan, M, Siam-Tsieu, V, Deblaise, J, El Mahmoud, R, Dubourg, O, Wierzbowska-Drabik, K, Plewka, M, Kasprzak, JD, Bandera, F, Generati, G, Pellegrino, M, Alfonzetti, E, Labate, V, Villani, S, Gaeta, M, Guazzi, M, Bandera, F, Generati, G, Pellegrino, M, Labate, V, Alfonzetti, E, Guazzi, M, Generati, G, Bandera, F, Pellegrino, M, Labate, V, Alfonzetti, E, Guazzi, M, Grycewicz, T, Szymanska, K, Grabowicz, W, Lubinski, A, Sotaquira, M, Pepi, M, Tamborini, G, Caiani, EG, Bochard Villanueva, B, Chacon-Hernandez, N, Fabregat-Andres, O, Garcia-Gonzalez, P, Cubillos-Arango, A, De La Espriella-Juan, R, Albiach-Montanana, C, Berenguer-Jofresa, A, Perez-Bosca, JL, Paya-Serrano, R, Cheng, H-L, Huang, C-H, Wang, Y-C, Chou, W-H, Kuznetsov, VA, Melnikov, NN, Krinochkin, DV, Kolunin, GV, Enina, TN, Sierraalta, W, Le Bihan, D, Barretto, RBM, Assef, JE, Gospos, M, Buffon, M, Ramos, AIO, Garcia, A, Pinto, IMF, Souza, AGMR, Mueller, H, Reverdin, S, Ehret, G, Conti, L, Dos Santos, S, Abdel Moneim, S S, Nhola, L F, Huang, R, Kohli, M, Longenbach, S, Green, M, Villarraga, H R, Bordun, K A, Jassal, D S, Mulvagh, S L, Evangelista, A, Madeo, A, Piras, P, Giordano, F, Giura, G, Teresi, L, Gabriele, S, Re, F, Puddu, P, Torromeo, C, Suwannaphong, S, Vathesatogkit, P, See, O, Yamwong, S, Katekao, W, Sritara, P, Iliuta, L, Szulik, M, Streb, W, Wozniak, A, Lenarczyk, R, Sliwinska, A, Kalarus, Z, Kukulski, T, Weng, K-P, Lin, C-C, Hein, S, Lehmann, L, Kossack, M, Juergensen, L, Katus, HA, Hassel, D, Turrini, F, Scarlini, S, Giovanardi, P, Messora, R, Mannucci, C, Bondi, M, Olander, R, Sundholm, JKM, Ojala, TH, Andersson, S, Sarkola, T, Karolyi, M, Kocsmar, I, Raaijmakers, R, Kitslaar, PH, Horvath, T, Szilveszter, B, Merkely, B, Maurovich-Horvat, P, Heart, Center, Vascular, University, Semmelweis, Budapest, Hungary, and Group, MTA-SE Lendület Cardiovascular Imaging Research

Abstract

Purpose: Although delayed-enhancement magnetic resonance imaging (DEMRI) is essential for diagnosis of cardiac sarcoidosis (CS), the test was not available when pacemaker was implamted. Recently, MR-conditional pacemaker has become avilable and we hypothesized that this device would be useful for diagnosis and management of CS. The aim of this study was to assess the diagnostic ability of MR-conditional pacemaker about CS in patients with advanced A-V nodal block (AAVB). Methods: Twenty-seven AAVB patients (14 men, 13 women; mean age, 69 ± 11 years) who were implanted MR-conditional pacemaker were studied. DEMRI was performed 6 weeks after implantation of permanent pacemaker. In patients with positive for DE, additional examinations like echocardiography, radioisotope imaging, biopsy, and coronary computed-tomography were performed due to confirm the diagnosis of CS and exclude coronary artery disease. Results: DE was observed in 12 patients (44 %). Out of 12 patients, 2 patients were excluded for having prior myocardial infarction. Seven of 10 (70 %) patients were diagnosed of CS by the consensus criteria. Compared with non-CS group, CS group had significantly lower age (61 ± 12 years vs. 72 ± 9 years p = 0.017). There was no significant difference about sex, angiotensin-converting enzyme, brain natriuretic peptide, and left ventricular ejection fraction between 2 groups. Six patients had started corticosteroid therapy and 5 patients (83%) recovered A-V nodal conduction. Conclusion: MR-conditional pacemaker was useful for diagnosis and management of patients with AAVB caused by CS. Figure Cardiac MRI in patient with AV block

Published
2014
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37. Poster session 3: Thursday 4 December 2014, 14:00-18:00 * Location: Poster area

Author

Shahgaldi, K, Hegner, T, Da Silva, C, Fukuyama, A, Takeuchi, M, Uema, A, Kado, Y, Nagata, Y, Hayashi, A, Otani, K, Fukuda, S, Yoshitani, H, Otsuji, Y, Morhy, S, Lianza, AC, Afonso, TR, Oliveira, WA, Tavares, GP, Rodrigues, AC, Vieira, MC, Warth, AN, Deutsch, AD, Fischer, CH, Tezynska-Oniszk, I, Turska-Kmiec, A, Kawalec, W, Dangel, J, Maruszewski, B, Bokiniec, R, Burczynski, P, Borszewska-Kornacka, K, Ziolkowska, L, Zuk, M, Mazowsza, eSUM Dzieciaki, Troshina, A, Dzhalilova, DA, Poteshkina, NG, Hamitov, FF, Warita, S, Kawasaki, M, Tanaka, R, Yagasaki, H, Minatoguchi, S, Wanatabe, T, Ono, K, Noda, T, Wanatabe, S, Minatoguchi, S, Angelis, A, Ageli, K, Vlachopoulos, C, Felekos, I, Ioakimidis, N, Aznaouridis, K, Vaina, S, Abdelrasoul, M, Tsiamis, E, Stefanadis, C, Cameli, M, Sparla, S, D'ascenzi, F, Fineschi, M, Favilli, R, Pierli, C, Henein, M, Mondillo, S, Lindqvist, P, Tossavainen, E, Gonzalez, M, Soderberg, S, Henein, M, Holmgren, A, Strachinaru, M, Catez, E, Jousten, I, Pavel, O, Janssen, C, Morissens, M, Chatzistamatiou, E, Moustakas, G, Memo, G, Konstantinidis, D, Mpampatzeva Vagena, I, Manakos, K, Traxanas, K, Vergi, N, Feretou, A, Kallikazaros, I, Tsai, W-C, Sun, Y-T, Lee, W-H, Yang, L-T, Liu, Y-W, Lee, C-H, Li, W-T, Mizariene, V, Bieseviciene, M, Karaliute, R, Verseckaite, R, Vaskelyte, J, Lesauskaite, V, Chatzistamatiou, E, Mpampatseva Vagena, I, Manakos, K, Moustakas, G, Konstantinidis, D, Memo, G, Mitsakis, O, Kasakogias, A, Syros, P, Kallikazaros, I, Hristova, K, Cornelissen, G, Singh, RB, Shiue, I, Coisne, D, Madjalian, A-M, Tchepkou, C, Raud Raynier, P, Degand, B, Christiaens, L, Baldenhofer, G, Spethmann, S, Dreger, H, Sanad, W, Baumann, G, Stangl, K, Stangl, V, Knebel, F, Azzaz, S, Kacem, S, Ouali, S, Risos, L, Dedobbeleer, C, Unger, P, Sinem Cakal, SC, Elif Eroglu, EE, Baydar, O, Beytullah Cakal, BC, Mehmet Vefik Yazicioglu, MVY, Mustafa Bulut, MB, Cihan Dundar, CD, Kursat Tigen, KT, Birol Ozkan, BO, Ali Metin Esen, AME, Tournoux, F, Chequer, R, Sroussi, M, Hyafil, F, Rouzet, F, Leguludec, D, Baum, P, Stoebe, S, Pfeiffer, D, Hagendorff, A, Fang, F, Lau, M, Zhang, Q, Luo, XX, Wang, XY, Chen, L, Yu, CM, -CRT, Predict, Zaborska, B, Smarz, K, Makowska, E, Kulakowski, P, Budaj, A, Bengrid, T M, Zhao, Y, Henein, M Y, Caminiti, G, D'antoni, V, Cardaci, V, Conti, V, Volterrani, M, Warita, S, Kawasaki, M, Yagasaki, H, Minatoguchi, S, Nagaya, M, Ono, K, Noda, T, Watanabe, S, Houle, H, Minatoguchi, S, Gillebert, T C, Chirinos, J A, Claessens, T C, Raja, M W, De Buyzere, M L, Segers, P, Rietzschel, E R, Investigators, The Asklepios, Kim, KH, Cha, JJ, Chung, HM, Kim, JY, Yoon, YW, Lee, BK, Hong, BK, Rim, SJ, Kwon, HM, Choi, EY, Pyankov, V, Aljaroudi, W, Matta, S, Al-Shaar, L, Habib, R, Gharzuddin, W, Arnaout, S, Skouri, H, Jaber, W, Abchee, A, Bouzas Mosquera, A, Peteiro, J, Broullon, FJ, Constanso Conde, IP, Bescos Galego, H, Martinez Ruiz, D, Yanez Wonenburger, JC, Vazquez Rodriguez, JM, Alvarez Garcia, N, Castro Beiras, A, Gunyeli, E, Oliveira Da Silva, C, Shahgaldi, K, Manouras, A, Winter, R, Meimoun, P, Abouth, S, Martis, S, Boulanger, J, Elmkies, F, Zemir, H, Detienne, JP, Luycx-Bore, A, Clerc, J, Rodriguez Palomares, J F, Gutierrez, LG, Maldonado, GM, Garcia, GG, Galuppo, VG, Gruosso, DG, Teixido, GT, Gonzalez Alujas, MTGA, Evangelista, AE, Garcia Dorado, DGD, Rechcinski, T, Wierzbowska-Drabik, K, Wejner-Mik, P, Szymanska, B, Jerczynska, H, Lipiec, P, Kasprzak, JD, El-Touny, K, El-Fawal, S, Loutfi, M, El-Sharkawy, E, Ashour, S, Boniotti, C, Carminati, MC, Fusini, L, Andreini, D, Pontone, G, Pepi, M, Caiani, EG, Oryshchyn, N, Kramer, B, Hermann, S, Liu, D, Hu, K, Ertl, G, Weidemann, F, Ancona, F, Miyazaki, S, Slavich, M, Figini, F, Latib, A, Chieffo, A, Montorfano, M, Alfieri, O, Colombo, A, Agricola, E, Nogueira, MA, Branco, LM, Rosa, SA, Portugal, G, Galrinho, A, Abreu, J, Cacela, D, Patricio, L, Fragata, J, Cruz Ferreira, R, Igual Munoz, B, Erdociain Perales, MEP, Maceira Gonzalez, AMG, Estornell Erill Jordi, JEE, Donate Bertolin, LDB, Vazquez Sanchez Alejandro, AVS, Miro Palau Vicente, VMP, Cervera Zamora, ACZ, Piquer Gil, MPG, Montero Argudo, AMA, Girgis, H Y A, Illatopa, V, Cordova, F, Espinoza, D, Ortega, J, Khan, US, Islam, AKMM, Majumder, AAS, Girgis, H Y A, Bayat, F, Naghshbandi, E, Naghshbandi, E, Samiei, N, Samiei, N, Malev, E, Omelchenko, M, Vasina, L, Zemtsovsky, E, Piatkowski, R, Kochanowski, J, Budnik, M, Scislo, P, Opolski, G, Kochanowski, J, Piatkowski, R, Scislo, P, Budnik, M, Marchel, M, Opolski, G, Abid, L, Ben Kahla, S, Abid, D, Charfeddine, S, Maaloul, I, Ben Jmaa, M, Kammoun, S, Hashimoto, G, Suzuki, M, Yoshikawa, H, Otsuka, T, Isekame, Y, Yamashita, H, Kawase, I, Ozaki, S, Nakamura, M, Sugi, K, Benvenuto, E, Leggio, S, Buccheri, S, Bonura, S, Deste, W, Tamburino, C, Monte, I P, Gripari, P, Fusini, L, Muratori, M, Tamborini, G, Ghulam Ali, S, Bottari, V, Cefalu', C, Bartorelli, A, Agrifoglio, M, Pepi, M, Zambon, E, Iorio, A, Di Nora, C, Abate, E, Lo Giudice, F, Di Lenarda, A, Agostoni, P, Sinagra, G, Timoteo, A T, Galrinho, A, Moura Branco, L, Rio, P, Aguiar Rosa, S, Oliveira, M, Silva Cunha, P, Leal, A, Cruz Ferreira, R, Zemanek, D, Tomasov, P, Belehrad, M, Kostalova, J, Kara, T, Veselka, J, Hassanein, M, El Tahan, S, El Sharkawy, E, Shehata, H, Yoon, YE, Choi, HM, Seo, HY, Lee, SP, Kim, HK, Youn, TJ, Kim, YJ, Sohn, DW, Choi, GY, Mielczarek, M, Huttin, O, Voilliot, D, Sellal, JM, Manenti, V, Carillo, S, Olivier, A, Venner, C, Juilliere, Y, Selton-Suty, C, Butz, T, Faber, L, Brand, M, Piper, C, Wiemer, M, Noelke, J, Sasko, B, Langer, C, Horstkotte, D, Trappe, HJ, Maysou, LA, Tessonnier, L, Jacquier, A, Serratrice, J, Copel, C, Stoppa, AM, Seguier, J, Saby, L, Verschueren, A, Habib, G, Petroni, R, Bencivenga, S, Di Mauro, M, Acitelli, A, Cicconetti, M, Romano, S, Petroni, A, Penco, M, Maceira Gonzalez, A M, Cosin-Sales, J, Igual, B, Sancho-Tello, R, Ruvira, J, Mayans, J, Choi, JH, Kim, SWK, Almeida, A, Azevedo, O, Amado, J, Picarra, B, Lima, R, Cruz, I, Pereira, V, Marques, N, Biering-Sorensen, T, Mogelvang, R, Schnohr, P, Jensen, JS, Chatzistamatiou, E, Konstantinidis, D, Manakos, K, Mpampatseva Vagena, I, Moustakas, G, Memo, G, Mitsakis, O, Kasakogias, A, Syros, P, Kallikazaros, I, Cho, EJ, Kim, JJ, Hwang, BH, Kim, DB, Jang, SW, Jeon, HK, Cho, JS, Chatzistamatiou, E, Konstantinidis, D, Memo, G, Mpapatzeva Vagena, I, Moustakas, G, Manakos, K, Traxanas, K, Vergi, N, Feretou, A, Kallikazaros, I, Jedrzejewska, I, Konopka, M, Krol, W, Swiatowiec, A, Dluzniewski, M, Braksator, W, Sefri Noventi, S, Sugiri, S, Uddin, I, Herminingsih, S, Arif Nugroho, M, Boedijitno, S, Caro Codon, J, Blazquez Bermejo, Z, Valbuena Lopez, S C, Lopez Fernandez, T, Rodriguez Fraga, O, Torrente Regidor, M, Pena Conde, L, Moreno Yanguela, M, Buno Soto, A, Lopez-Sendon, J L, Stevanovic, A, Dekleva, M, Kim, MN, Kim, SA, Kim, YH, Shim, JM, Park, SM, Park, SW, Kim, YH, Shim, WJ, Kozakova, M, Muscelli, E, Morizzo, C, Casolaro, A, Paterni, M, Palombo, C, Bayat, F, Nazmdeh, M, Naghshbandi, E, Nateghi, S, Tomaszewski, A, Kutarski, A, Brzozowski, W, Tomaszewski, M, Nakano, E, Harada, T, Takagi, Y, Yamada, M, Takano, M, Furukawa, T, Akashi, Y, Lindqvist, G, Henein, MY, Backman, C, Gustafsson, S, Morner, S, Marinov, R, Hristova, K, Geirgiev, S, Pechilkov, D, Kaneva, A, Katova, TZ, Pilosoff, V, Pena Pena, ML, Mesa Rubio, D, Ruiz Ortin, M, Delgado Ortega, M, Romo Penas, E, Pardo Gonzalez, L, Rodriguez Diego, S, Hidalgo Lesmes, F, Pan Alvarez-Ossorio, M, Suarez De Lezo Cruz-Conde, J, Gospodinova, M, Sarafov, S, Guergelcheva, V, Vladimirova, L, Tournev, I, Denchev, S, Mozenska, O, Segiet, A, Rabczenko, D, Kosior, DA, Gao, SA, Eliasson, M, Polte, CL, Lagerstrand, K, Bech-Hanssen, O, Morosin, M, Piazza, R, Leonelli, V, Leiballi, E, Pecoraro, R, Cinello, M, Dell' Angela, L, Cassin, M, Sinagra, G, Nicolosi, GL, Savu, O, Carstea, N, Stoica, E, Macarie, C, Moldovan, H, Iliescu, V, Chioncel, O, Moral, S, Gruosso, D, Galuppo, V, Teixido, G, Rodriguez-Palomares, JF, Gutierrez, L, Evangelista, A, Jansen Klomp, W W, Peelen, LM, Spanjersberg, AJ, Brandon Bravo Bruinsma, GJ, Van 'T Hof, AWJ, Laveau, F, Hammoudi, N, Helft, G, Barthelemy, O, Michel, PL, Petroni, T, Djebbar, M, Boubrit, L, Le Feuvre, C, Isnard, R, Cho, EJ, Park, S-J, Kim, CH, Song, JE, Kim, SH, Chang, S-A, Lee, S-C, Park, SW, Bandera, F, Generati, G, Pellegrino, M, Alfonzetti, E, Labate, V, Villani, S, Gaeta, M, Guazzi, M, Gabriels, C, Lancellotti, P, Van De Bruaene, A, Voilliot, D, De Meester, P, Buys, R, Delcroix, M, Budts, W, Cruz, I, Stuart, B, Caldeira, D, Morgado, G, Almeida, AR, Lopes, LR, Fazendas, P, Joao, I, Cotrim, C, Pereira, H, Weissler Snir, A, Greenberg, G, Shapira, Y, Weisenberg, D, Monakier, D, Nevzorov, R, Sagie, A, Vaturi, M, Bando, M, Yamada, H, Saijo, Y, Takagawa, Y, Sawada, N, Hotchi, J, Hayashi, S, Hirata, Y, Nishio, S, Sata, M, Jackson, TA, Sammut, E, Siarkos, M, Lee, L, Carr-White, G, Rajani, R, Kapetanakis, S, Ciobotaru, V, Yagasaki, H, Kawasaki, M, Tanaka, R, Minatoguchi, S, Sato, N, Amano, K, Warita, S, Ono, K, Noda, T, Minatoguchi, S, Breithardt, O-A, Razavi, H, Nabutovsky, Y, Ryu, K, Gaspar, T, Kosiuk, J, John, S, Prinzen, F, Hindricks, G, Piorkowski, C, Nemchyna, O, Tovstukha, V, Chikovani, A, Golikova, I, Lutai, M, Nemes, A, Kalapos, A, Domsik, P, Lengyel, C, Orosz, A, Forster, T, Nordenfur, T, Babic, A, Giesecke, A, Bulatovic, I, Ripsweden, J, Samset, E, Winter, R, Larsson, M, Blazquez Bermejo, Z, Lopez Fernandez, T, Caro Codon, J, Valbuena, SC, Caro Codon, J, Mori Junco, R, Moreno Yanguela, M, Lopez-Sendon, JL, MEdicamentos, Grupo de Estudio de CArdiotoxicidad por, Pinto-Teixeira, P, Branco, L, Galrinho, A, Oliveira, M, Cunha, P, Silva, T, Rio, P, Feliciano, J, Nogueira-Silva, M, Ferreira, R, Shkolnik, E, Vasyuk, Y, Nesvetov, V, Shkolnik, L, Varlan, G, Bajraktari, G, Ronn, F, Ibrahimi, P, Jashari, F, Jensen, SM, Henein, MY, Kang, M-K, Mun, H-S, Choi, S, Cho, J-R, Han, SW, Lee, N, Cho, I J, Heo, R, Chang, HJ, Shin, S, Shim, CY, Hong, GR, and Chung, N

Abstract

Objective:  We aimed to investigate the reproducibility of vena contracta (VC) in mitral regurgitation (MR) of different etiology between an inexperienced and an experienced echocardiographer. Background: MR is the second most common valvular heart disease in Europe that requires surgery.  Echocardiography is the principal modality of investigation when MR is suspected. In European and American guidelines VC is described as one of the most feasible echocardiographic measurements in the assessment of MR. There is a lack of publications regarding intra-observer variability and studies comparing inexperienced and experienced echocardiographers for the assessment of VC. Method/Material: VC of 55 recorded 2D echocardiograms with known MR of different degree and etiology were analyzed from parasternal long axis view, 4- and 3 chamber view. The mean value of the different plane measurements of each exam was used for statistical analysis. Analyses were made by an inexperienced (A) fellow echocardiographer (<100 studies) and a level 3 experienced (B) echocardiographer. Measurements of VC by the 2 echocardiographers were performed blinded to clinical data. Measurements were performed with at least 2 weeks apart, blinded to the first measurement. Results: Three exams were excluded (feasibility 95%) from statistical analysis because adequate color Doppler images from all tree planes was not available. The inter class correlation (ICC) between the first and second analysis was (r=0.75; 95% CI -1.1 to 1.7mm) for A and (r=0.94; 95% CI -0.76 to 0.84mm) for B. There was good ICC between the 2 echocardiographers (r=0.78; 95% CI -1.5 to 1.3mm). The intra observer variability was 11.1% for A and 6.1% for B. The inter observer variability was 11.7% (p>0.05 for all). Conclusion: Measurement of vena contracta in mitral regurgitation is a feasible semi-quantitative parameter. Good correlation and narrow limits of agreement between a novice and an experienced echocardiographer was demonstrated in our study.

Published
2014
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38. Impact of clinical and genetic findings on the management of young patients with Brugada syndrome

Author

Vincent Probst, Philippe Maury, Béatrice Delasalle, Peter J. Schwartz, Dominique Babuty, Frederic Sacher, Jean-Baptiste Gourraud, Isabelle Denjoy, Bertrand Petit, Laurence Jesel, Bruno Degand, Arthur A.M. Wilde, Lia Crotti, Yves Dulac, Federica Dagradi, Alice Maltret, Philippe Mabo, Elijah R. Behr, Antoine Andorin, Géraldine Bertaux, Leonie C.H. Wong, Nico A. Blom, Andorin, A, Behr, E, Denjoy, I, Crotti, L, Dagradi, F, Jesel, L, Sacher, F, Petit, B, Mabo, P, Maltret, A, Wong, L, Degand, B, Bertaux, G, Maury, P, Dulac, Y, Delasalle, B, Gourraud, J, Babuty, D, Blom, N, Schwartz, P, Wilde, A, Probst, V, ACS - Amsterdam Cardiovascular Sciences, Paediatric Cardiology, and Cardiology

Subjects
medicine.medical_specialty, 030204 cardiovascular system & hematology, Ventricular tachycardia, Asymptomatic, Pediatrics, Sudden cardiac death, 03 medical and health sciences, 0302 clinical medicine, Genetic, Physiology (medical), Internal medicine, medicine, Brugada syndrome, genetics, cardiovascular diseases, 030212 general & internal medicine, Adverse effect, Genetic testing, Asymptomatic Diseases, Pediatric, therapy, medicine.diagnostic_test, business.industry, ECG, clinical manifestation, MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE, medicine.disease, Quinidine, 3. Good health, Cardiology, medicine.symptom, Cardiology and Cardiovascular Medicine, business, Electrocardiography, Arrhythmia, sodium channel
Abstract

BACKGROUND: Brugada syndrome (BrS) is an arrhythmogenic disease associated with sudden cardiac death (SCD) that seldom manifests or is recognized in childhood. OBJECTIVES: The objectives of this study were to describe the clinical presentation of pediatric BrS to identify prognostic factors for risk stratification and to propose a data-based approach management. METHODS: We studied 106 patients younger than 19 years at diagnosis of BrS enrolled from 16 European hospitals. RESULTS: At diagnosis, BrS was spontaneous (n = 36, 34%) or drug-induced (n = 70, 66%). The mean age was 11.1 ± 5.7 years, and most patients were asymptomatic (family screening, (n = 67, 63%; incidental, n = 13, 12%), while 15 (14%) experienced syncope, 6(6%) aborted SCD or symptomatic ventricular tachycardia, and 5 (5%) other symptoms. During follow-up (median 54 months), 10 (9%) patients had life-threatening arrhythmias (LTA), including 3 (3%) deaths. Six (6%) experienced syncope and 4 (4%) supraventricular tachycardia. Fever triggered 27% of LTA events. An implantable cardioverter-defibrillator was implanted in 22 (21%), with major adverse events in 41%. Of the 11 (10%) patients treated with hydroquinidine, 8 remained asymptomatic. Genetic testing was performed in 75 (71%) patients, and SCN5A rare variants were identified in 58 (55%); 15 of 32 tested probands (47%) were genotype positive. Nine of 10 patients with LTA underwent genetic testing, and all were genotype positive, whereas the 17 SCN5A-negative patients remained asymptomatic. Spontaneous Brugada type 1 electrocardiographic (ECG) pattern (P = .005) and symptoms at diagnosis (P = .001) were predictors of LTA. Time to the first LTA event was shorter in patients with both symptoms at diagnosis and spontaneous Brugada type 1 ECG pattern (P = .006). CONCLUSION: Spontaneous Brugada type 1 ECG pattern and symptoms at diagnosis are predictors of LTA events in the young affected by BrS. The management of BrS should become age-specific, and prevention of SCD may involve genetic testing and aggressive use of antipyretics and quinidine, with risk-specific consideration for the implantable cardioverter-defibrillator.

Published
2016

39. QRS-T angle: is it a specific parameter associated with sudden cardiac death in type 2 diabetes? Results from the SURDIAGENE and the Mini-Finland prospective cohorts.

Author

Garcia R, Schröder LC, Tavernier M, Gand E, de Keizer J, Holkeri A, Eranti A, Bidegain N, Alos B, Junttila J, Knekt P, Roumegou P, Gamet A, Bouleti C, Degand B, Ragot S, Hadjadj S, Aro AL, and Saulnier PJ

Subjects
Humans, Male, Aged, Female, Cohort Studies, Prospective Studies, Finland, Risk Assessment, Electrocardiography adverse effects, Electrocardiography methods, Death, Sudden, Cardiac etiology, Risk Factors, Diabetes Mellitus, Type 2 complications
Abstract

Aims/hypothesis: Type 2 diabetes is associated with a high risk of sudden cardiac death (SCD), but the risk of dying from another cause (non-SCD) is proportionally even higher. The aim of the study was to identify easily available ECG-derived features associated with SCD, while considering the competing risk of dying from non-SCD causes., Methods: In the SURDIAGENE (Survie, Diabete de type 2 et Genetique) French prospective cohort of individuals with type 2 diabetes, 15 baseline ECG parameters were interpreted among 1362 participants (mean age 65 years; HbA 1c 62±17 mmol/mol [7.8±1.5%]; 58% male). Competing risk models assessed the prognostic value of clinical and ECG parameters for SCD after adjusting for age, sex, history of myocardial infarction, N-terminal pro b-type natriuretic peptide (NT-proBNP), HbA 1c and eGFR. The prospective Mini-Finland cohort study was used to externally validate our findings., Results: During median follow-up of 7.4 years, 494 deaths occurred including 94 SCDs. After adjustment, frontal QRS-T angle ≥90° (sub-distribution HR [sHR] 1.68 [95% CI 1.04, 2.69], p=0.032) and NT-proBNP level (sHR 1.26 [95% CI 1.06, 1.50] per 1 log, p=0.009) were significantly associated with a higher risk of SCD. Nevertheless, frontal QRS-T angle was the only marker not to be associated with causes of death other than SCD (sHR 1.08 [95% CI 0.84, 1.39], p=0.553 ). These findings were replicated in the Mini-Finland study subset of participants with diabetes (sHR 2.22 [95% CI 1.05, 4.71], p=0.04 for SCD and no association for other causes of death)., Conclusions/interpretation: QRS-T angle was specifically associated with SCD risk and not with other causes of death, opening an avenue for refining SCD risk stratification in individuals with type 2 diabetes., (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

Published
2024
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40. Pre-emptive treatment of heart failure exacerbations in patients managed with the HeartLogic™ algorithm.

Author

Garcia R, Gras D, Mansourati J, Defaye P, Bisson A, Boveda S, Gandjbakhch E, Gras M, Gueffet JP, Himbert C, Jacon P, Khattar P, Lequeux B, Li A, Mansourati V, Minois D, Marijon E, Pierre B, Probst V, and Degand B

Subjects
Humans, Cohort Studies, Stroke Volume, Prospective Studies, Biological Specimen Banks, Ventricular Function, Left, Algorithms, Quality of Life, Heart Failure
Abstract

Aims: Heart failure (HF) is a chronic disease affecting 64 million people worldwide and places a severe burden on society because of its mortality, numerous re-hospitalizations and associated costs. HeartLogic™ is an algorithm programmed into implanted devices incorporating several biometric parameters which aims to predict HF episodes. It provides an index which can be monitored remotely, allowing pre-emptive treatment of congestion to prevent acute decompensation. We aim to assess the impact and security of pre-emptive HF management, guided by the HeartLogic™ index., Methods and Results: The HeartLogic™ France Cohort Study is an investigator-initiated, prospective, multi-centre, non-randomized study. Three hundred ten patients with a history of HF (left ventricular ejection fraction ≤40%; or at least one episode of clinical HF with elevated NT-proBNP ≥450 ng/L) and implanted with a cardioverter defibrillator enabling HeartLogic™ index calculation will be included across 10 French centres. The HeartLogic™ index will be monitored remotely for 12 months and in the event of a HeartLogic™ index ≥16, the local investigator will contact the patient for assessment and adjust HF treatment as necessary. The primary endpoint is unscheduled hospitalization for HF. Secondary endpoints are all-cause mortality, cardiovascular death, HF-related death, unscheduled hospitalizations for ventricular or atrial arrhythmia and HeartLogic™ index evolution over time. Blood samples will be collected for biobanking, and quality of life will be assessed. Finally, the safety of a HeartLogic™-triggered strategy for initiating or increasing diuretic therapy will be assessed. A blind and independent committee will adjudicate the events., Conclusions: The HeartLogic™ France Cohort Study will provide robust real-world data in a cohort of HF patients managed with the HeartLogic™ algorithm allowing pre-emptive treatment of heart failure exacerbations., (© 2024 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.)

Published
2024
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41. Asymptomatic left circumflex artery stenosis is associated with higher arrhythmia recurrence after persistent atrial fibrillation ablation.

Author

Garcia R, Clouard M, Plank F, Degand B, Philibert S, Laurent G, Poupin P, Sakhy S, Gras M, Stühlinger M, Szegedi N, Herczeg S, Simon J, Crijns HJGM, Marijon E, Christiaens L, and Guenancia C

Abstract

Background: The pathophysiology of persistent atrial fibrillation (AF) remains unclear. While several studies have demonstrated an association between myocardial infarction and atrial fibrillation, the role of stable coronary artery disease (CAD) is still unknown. As a result, we aimed to assess the association between CAD obstruction and AF recurrence after persistent AF ablation in patients with no history of CAD., Materials and Methods: This observational retrospective study included consecutive patients who underwent routine preprocedural cardiac computed tomography (CCT) before persistent AF ablation between September 2015 and June 2018 in 5 European University Hospitals. Exclusion criteria were CAD or coronary revascularization previously known or during follow-up. Obstructive CAD was defined as luminal stenosis ≥ 50%., Results: All in all, 496 patients (mean age 61.8 ± 10.0 years, 76.2% males) were included. CHA 2 DS 2 -VASc score was 0 or 1 in 225 (36.3%) patients. Obstructive CAD was present in 86 (17.4%) patients. During the follow-up (24 ± 19 months), 207 (41.7%) patients had AF recurrence. The recurrence rate was not different between patients with and without obstructive CAD (43.0% vs. 41.5%, respectively; P = 0.79). When considering the location of the stenosis, the recurrence rate was higher in the case of left circumflex obstruction: 56% vs. 32% at 2 years (log-rank P ≤ 0.01). After Cox multivariate analysis, circumflex artery obstruction (HR 2.32; 95% CI 1.36-3.98; P < 0.01) was independently associated with AF recurrence., Conclusion: Circumflex artery obstruction detected with CCT was independently associated with 2-fold increase in the risk of AF recurrence after persistent AF ablation. Further research is necessary to evaluate this pathophysiological relationship., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Garcia, Clouard, Plank, Degand, Philibert, Laurent, Poupin, Sakhy, Gras, Stühlinger, Szegedi, Herczeg, Simon, Crijns, Marijon, Christiaens and Guenancia.)

Published
2022
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42. Septal versus apical pacing sites in permanent right ventricular pacing: The multicentre prospective SEPTAL-PM study.

Author

Galand V, Martins RP, Donal E, Behar N, Crocq C, Soulié GG, Degand B, Garcia R, Solnon A, Lande G, Probst V, Marjaneh F, Mansourati J, Dupuis JM, Laviolle B, and Leclercq C

Subjects
Cardiac Pacing, Artificial adverse effects, Heart Ventricles diagnostic imaging, Humans, Prospective Studies, Quality of Life, Stroke Volume, Treatment Outcome, Ventricular Function, Left, Atrioventricular Block diagnosis, Atrioventricular Block therapy, Pacemaker, Artificial, Ventricular Dysfunction, Left
Abstract

Background: The optimal right ventricular pacing site for patients requiring pacemaker implantation for permanent atrioventricular block is a matter of debate. Long-term right ventricular apical pacing has been associated with left ventricular ejection fraction impairment and heart failure. Right ventricular septal pacing has been proposed as an alternative., Aim: The aim of this randomized prospective multicentre trial was to compare left ventricular remodelling and outcomes between right ventricular apical and septal pacing after mid-term follow-up., Methods: Patients requiring pacemaker implantation for high-degree atrioventricular block were enrolled and randomized in a 1:1 fashion to receive a right ventricular apical or septal lead., Results: A total of 141 patients were included, 69 in the septal group and 72 in the apical group. Both groups exhibited similar left ventricular ejection fractions after 18 months of follow-up (septal 57.1±11.9% vs. apical 57.4±13.4%), and left ventricular ejection fraction variation was similar in the two groups at the end of follow-up (septal -1.5±13.2% vs. apical 0.3±13.3%). Additionally, left ventricular volume, quality of life and 6-minute walk distance were similar in the two groups. However, patients in the septal group were more likely to be asymptomatic, with a significantly lower concentration of N-terminal prohormone of brain natriuretic peptide. Lastly, lead position did not impact 18-month survival., Conclusion: Pacing from the right ventricular apex does not have any detrimental effect on left ventricular systolic function compared with septal pacing over an 18-month period., (Copyright © 2022. Published by Elsevier Masson SAS.)

Published
2022
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43. Cardiovascular outcomes after cardiac resynchronization therapy in cardiac amyloidosis.

Author

Fischer K, Lellouche N, Damy T, Martins R, Clementy N, Bisson A, Lesaffre F, Espinosa M, Garcia R, Degand B, Serzian G, Jourda F, Huttin O, Guichard JB, Devilliers H, Eicher JC, Laurent G, and Guenancia C

Subjects
Aged, Aged, 80 and over, Humans, Retrospective Studies, Stroke Volume physiology, Treatment Outcome, Ventricular Function, Left physiology, Amyloidosis complications, Amyloidosis diagnosis, Amyloidosis therapy, Cardiac Resynchronization Therapy methods, Defibrillators, Implantable
Abstract

Aims: Cardiac resynchronization therapy (CRT) is highly effective in dilated cardiomyopathy (DCM) patients with impaired left ventricular ejection fraction (LVEF) and left bundle block branch. In cardiac amyloidosis (CA) patients, left ventricular dysfunction and conduction defects are common, but the potential of CRT to improve cardiac remodelling and survival in this particular setting remains undefined. We investigated cardiovascular outcomes in CA patients after CRT implantation in terms of CRT echocardiographic response and major cardiovascular events (MACEs)., Methods and Results: Our retrospective study included 47 CA patients implanted with CRT devices from January 2012 to February 2020, in nine French university hospitals (77 ± 6 years old, baseline LVEF 30 ± 8%) compared with propensity-matched (1:1 for age, LVEF at implantation, and CRT indication) DCM patients with a CRT device. CA patients had lower rates of CRT response (absolute delta LVEF ≥ 10%) compared with DCM patients (36% vs. 70%, P = 0.002). After multivariate Cox analysis, CA was independently associated with MACE (hospitalization for heart failure/cardiovascular death) [hazard ratio (HR) 3.73, 95% confidence interval (CI) 1.85-7.54, P < 0.001], along with the absence of CRT response (HR 3.01, 95% CI 1.56-5.79, P = 0.001). The presence of echocardiographic CRT response (absolute delta LVEF ≥ 10%) was the only predictive factor of MACE-free survival in CA patients (HR 0.36, 95% CI 0.15-0.86, P = 0.002)., Conclusion: Compared with a matched cohort of DCM patients, CA patients had a lower rate of CRT response and consequently a worse cardiovascular prognosis after CRT implantation. However, CRT could be beneficial even in CA patients given that CRT response was associated with better cardiac outcomes in this population., (© 2021 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.)

Published
2022
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44. Non-invasive hemodynamic determination of patient-specific optimal pacing mode in cardiac resynchronization therapy.

Author

Ferchaud V, Garcia R, Bidegain N, Degand B, Milliez P, Pezel T, and Moubarak G

Subjects
Bundle-Branch Block diagnostic imaging, Bundle-Branch Block therapy, Cardiac Resynchronization Therapy Devices, Hemodynamics, Humans, Treatment Outcome, Cardiac Resynchronization Therapy, Heart Failure diagnostic imaging, Heart Failure therapy
Abstract

Purpose: Cardiac resynchronization therapy (CRT) devices have multiple programmable pacing parameters. The purpose of this study was to determine the best pacing mode, i.e., associated with the greatest acute hemodynamic response, in each patient., Methods: Patients in sinus rhythm and intact atrioventricular conduction were included within 3 months of implantation of devices featuring SyncAV and multipoint pacing (MPP) algorithms. The effect of nominal biventricular pacing using the latest activated electrode (BiV-Late), optimized atrioventricular delay (AVD), nominal and optimized SyncAV, and anatomical MPP was determined by non-invasive measurement of systolic blood pressure (SBP). CRT response was defined as SBP increase > 10% relative to baseline., Results: Thirty patients with left bundle branch block (LBBB) were included. BiV-Late increased SBP compared to intrinsic rhythm (128 ± 21 mmHg vs. 121 ± 22 mmHg, p = 0.0002). The best pacing mode further increased SBP to 140 ± 19 mmHg (p < 0.0001 vs. BiV-Late). The proportion of CRT responders increased from 40% with BiV-Late to 80% with the best pacing mode (p = 0.0005). Compared to BiV-Late, optimized AVD and optimized SyncAV increased SBP (to 134 ± 21 mmHg, p = 0.004, and 133 ± 20 mmHg, p = 0.0003, respectively), but nominal SyncAV and MPP did not. The best pacing mode was variable between patients and was different from nominal BiV-Late in 28 (93%) patients. Optimized AVD was the most frequent best mode, in 14 (47%) patients., Conclusion: In patients with LBBB, the best pacing mode was patient-specific and doubled the magnitude of acute hemodynamic response and the proportion of acute CRT responders compared to nominal BiV-Late pacing., Trial Registration: ClinicalTrials.gov : NCT03779802., (© 2020. Springer Science+Business Media, LLC, part of Springer Nature.)

Published
2021
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45. Impact of the atrial lead pacing site regarding atrial fibrillation onset in patients with sinus node dysfunction.

Author

Pernollet P, Gras M, Bidegain N, Gal FL, Christiaens L, Degand B, and Garcia R

Subjects
Cardiac Pacing, Artificial adverse effects, Female, Humans, Male, Retrospective Studies, Sick Sinus Syndrome diagnosis, Sick Sinus Syndrome epidemiology, Sick Sinus Syndrome therapy, Atrial Appendage, Atrial Fibrillation diagnosis, Atrial Fibrillation epidemiology, Atrial Fibrillation therapy
Abstract

Symptomatic sinus node disease (SND) most frequently requires the implantation of a dual chamber pacemaker of which the right atrial lead is generally implanted in the right atrial appendage (RAA) or the lateral wall (LW).The aim of this retrospective study was to evaluate the impact of the right atrial lead pacing site regarding the onset of AF in patients with SND. RESULTS: 126 patients were included (53% males; 76 yo). 64 (51%) patients were implanted in the RAA and 62 (49%) in the LW. The two groups were not different in terms of CHA 2 DS 2 -VASc score and indexed left atrial volume. Forty-eight months after implantation, AF occurred in 17 (26.6%) of the RAA group and 6 (9.7%) in the lateral group. In the multivariate models, RAA site was the only factor associated with AF onset, with an Hazard Ratio of 2.5 (95%CI 1.1; 5.7; P=0.03). CONCLUSION: In our study, RAA pacing was associated with 2.5 higher risk of AF onset in patients with SND. Further larger randomized studies are needed to confirm these findings., (Copyright © 2021 Elsevier B.V. All rights reserved.)

Published
2021
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46. Virtual Reality for Sedation During Atrial Fibrillation Ablation in Clinical Practice: Observational Study.

Author

Roxburgh T, Li A, Guenancia C, Pernollet P, Bouleti C, Alos B, Gras M, Kerforne T, Frasca D, Le Gal F, Christiaens L, Degand B, and Garcia R

Subjects
Female, Humans, Male, Middle Aged, Pain, Pain Management, Treatment Outcome, Atrial Fibrillation surgery, Catheter Ablation, Virtual Reality
Abstract

Background: Connected devices are dramatically changing many aspects in health care. One such device, the virtual reality (VR) headset, has recently been shown to improve analgesia in a small sample of patients undergoing transcatheter aortic valve implantation., Objective: We aimed to investigate the feasibility and effectiveness of VR in patients undergoing atrial fibrillation (AF) ablation under conscious sedation., Methods: All patients who underwent an AF ablation with VR from March to May 2020 were included. Patients were compared to a consecutive cohort of patients who underwent AF ablation in the 3 months prior to the study. Primary efficacy was assessed by using a visual analog scale, summarizing the overall pain experienced during the ablation., Results: The AF cryoablation procedure with VR was performed for 48 patients (mean age 63.0, SD 10.9 years; n=16, 33.3% females). No patient refused to use the device, although 14.6% (n=7) terminated the VR session prematurely. Preparation of the VR headset took on average 78 (SD 13) seconds. Compared to the control group, the mean perceived pain, assessed with the visual analog scale, was lower in the VR group (3.5 [SD 1.5] vs 4.3 [SD 1.6]; P=.004), and comfort was higher in the VR group (7.5 [SD 1.6] vs 6.8 [SD 1.7]; P=.03). On the other hand, morphine consumption was not different between the groups. Lastly, complications, as well as procedure and fluoroscopy duration, were not different between the two groups., Conclusions: We found that VR was associated with a reduction in the perception of pain in patients undergoing AF ablation under conscious sedation. Our findings demonstrate that VR can be easily incorporated into the standard ablation workflow., (©Thomas Roxburgh, Anthony Li, Charles Guenancia, Patrice Pernollet, Claire Bouleti, Benjamin Alos, Matthieu Gras, Thomas Kerforne, Denis Frasca, François Le Gal, Luc Christiaens, Bruno Degand, Rodrigue Garcia. Originally published in the Journal of Medical Internet Research (https://www.jmir.org), 27.05.2021.)

Published
2021
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47. Wearable cardioverter-defibrillator in patients with a transient risk of sudden cardiac death: the WEARIT-France cohort study.

Author

Garcia R, Combes N, Defaye P, Narayanan K, Guedon-Moreau L, Boveda S, Blangy H, Bouet J, Briand F, Chevalier P, Cottin Y, Da Costa A, Degand B, Deharo JC, Eschalier R, Extramiana F, Goralski M, Guy-Moyat B, Guyomar Y, Hermida JS, Jourda F, Lellouche N, Mahfoud M, Manenti V, Mansourati J, Martin A, Pasquié JL, Ritter P, Rollin A, Tibi T, Yalioua A, Gras D, Sadoul N, Piot O, Leclercq C, and Marijon E

Subjects
Aged, Cohort Studies, Death, Sudden, Cardiac epidemiology, Death, Sudden, Cardiac prevention & control, Defibrillators, Electric Countershock, Female, France epidemiology, Humans, Male, Middle Aged, Retrospective Studies, Treatment Outcome, Defibrillators, Implantable, Wearable Electronic Devices
Abstract

Aims: We aimed to provide contemporary real-world data on wearable cardioverter-defibrillator (WCD) use, not only in terms of effectiveness and safety but also compliance and acceptability., Methods and Results: Across 88 French centres, the WEARIT-France study enrolled retrospectively patients who used the WCD between May 2014 and December 2016, and prospectively all patients equipped for WCD therapy between January 2017 and March 2018. All patients received systematic education session through a standardized programme across France at the time of initiation of WCD therapy and were systematically enrolled in the LifeVest Network remote services. Overall, 1157 patients were included (mean age 60 ± 12 years, 16% women; 46% prospectively): 82.1% with ischaemic cardiomyopathy, 10.3% after implantable cardioverter-defibrillator explant, and 7.6% before heart transplantation. Median WCD usage period was 62 (37-97) days. Median daily wear time of WCD was 23.4 (22.2-23.8) h. In multivariate analysis, younger age was associated with lower compliance [adjusted odds ratio (OR) 0.97, 95% confidence interval (CI) 0.95-0.99, P < 0.01]. A total of 18 participants (1.6%) received at least one appropriate shock, giving an incidence of appropriate therapy of 7.2 per 100 patient-years. Patient-response button allowed the shock to be aborted in 35.7% of well-tolerated sustained ventricular arrhythmias and in 95.4% of inappropriate ventricular arrhythmia detection, finally resulting in an inappropriate therapy in eight patients (0.7%)., Conclusion: Our real-life findings reinforce previous studies on the efficacy and safety of the WCD in the setting of transient high-risk group in selected patients. Moreover, they emphasize the fact that when prescribed appropriately, in concert with adequate patient education and dedicated follow-up using specific remote monitoring system, compliance with WCD is high and the device well-tolerated by the patient., (© The Author(s) 2020. Published by Oxford University Press on behalf of the European Society of Cardiology.)

Published
2021
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48. Hypnosis Versus Placebo During Atrial Flutter Ablation: The PAINLESS Study: A Randomized Controlled Trial.

Author

Garcia R, Bouleti C, Li A, Frasca D, El Harrouchi S, Marechal J, Roumegou P, Corbi P, Christiaens L, Le Gal F, and Degand B

Subjects
Aged, Analgesics, Opioid therapeutic use, Female, Humans, Male, Morphine therapeutic use, Atrial Flutter surgery, Catheter Ablation, Hypnosis
Abstract

Objectives: The aim of this study was to assess the superiority of hypnosis versus placebo on pain perception and morphine consumption during typical atrial flutter (AFL) ablation., Background: AFL ablation commonly requires intravenous opioid for analgesia, which can be associated with adverse outcomes. Hypnosis is an alternative technique with rising interest, but robust data in electrophysiological procedures are lacking., Methods: This single center, randomized controlled trial compared hypnosis and placebo during AFl ablation. In addition to the randomized intervention, all patients were treated according to the institution's standard of care analgesia protocol (administration of 1 mg of intravenous morphine in case of self-reported pain ≥5 on an 11-point numeric rating scale or on demand). The primary endpoint was perceived pain quantified by patients using a visual analog scale., Results: Between October 2017 and September 2019, 113 patients (mean age 70 ± 12 years, 21% women) were randomized to hypnosis (n = 56) or placebo (n = 57). Mean pain score was 4.0 ± 2.2 in the hypnosis group versus 5.5 ± 1.8 in the placebo group (p < 0.001). Pain perception, assessed every 5 min during the whole procedure, was consistently lower in the hypnosis group. Patients' sedation scores were also better in the hypnosis group than in the placebo group (8.3 ± 2.2 vs. 5.4 ± 2.5; p < 0.001). Finally, morphine requirements were significantly lower in the hypnosis group (1.3 ± 1.3 mg) compared with the placebo group (3.6 ± 1.8 mg; p < 0.001)., Conclusions: In this first randomized trial, hypnosis during AFL ablation was superior to placebo for alleviating pain and reducing morphine consumption., Competing Interests: Author Relationship With Industry Dr. Garcia has received consulting fees from St. Jude Medical and Boston Scientific. Drs. Le Gal and Degand have received consulting fees from Sorin Group, St. Jude Medical, and Boston Scientific. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose., (Copyright © 2020 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.)

Published
2020
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49. Effectiveness of Deep Sedation for Patients With Intractable Electrical Storm Refractory to Antiarrhythmic Drugs.

Author

Martins RP, Urien JM, Barbarot N, Rieul G, Sellal JM, Borella L, Clementy N, Bisson A, Guenancia C, Sagnard A, Schumacher S, Gandjbakhch E, Duchateau J, Tixier R, Goepp A, Hamon D, Lellouche N, Champ-Rigot L, Milliez P, Marijon E, Varlet E, Garcia R, Degand B, Bouju P, Mabo P, Leclercq C, Behar N, Pavin D, de Chillou C, Sacher F, and Galand V

Subjects
Aged, Humans, Anti-Arrhythmia Agents therapeutic use, Deep Sedation methods, Tachycardia, Ventricular drug therapy
Published
2020
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50. [Screening and diagnosis of atrial fibrillation].

Author

Roumegou P, Degand B, Le Gal F, and Garcia R

Subjects
Aged, Electrocardiography, Humans, Mass Screening, Atrial Fibrillation diagnosis, Atrial Fibrillation epidemiology, Cardiology, Stroke diagnosis, Stroke epidemiology
Abstract

Screening and diagnosis of atrial fibrillation. Screening for atrial fibrillation (AF) is crucial as this arrhythmia is asymptomatic in a third of patients and 5% of patients present a stroke as the first manifestation of their AF. The European Society of Cardiology recommends opportunistic screening of AF in patients over 65 years of age and systematically in patients over 75 years of age. The simplest way is pulse taking, but the number of connected devices for AF screening allows to multiply the frequency of screening and thus increase sensitivity, with another advantage of a digitalized transmission of the tracing. However many questions remain. No scientific evidence has demonstrated a benefit for AF screening. We do not know what duration and frequency of screening is relevant. The burden of AF which increases thromboembolic risk is not known. What population should be screened and how to consider subclinical AF? We will obtain answers to our questions in the coming years thanks to the results of the various studies in progress., Competing Interests: P. Roumegou déclare n’avoir aucun lien d’intérêts. F. Le Gal et B. Degand sont consultants pour Boston Scientific, Abbott et Microport. R. Garcia est consultant pour Boston Scientific et Abbott.

Published
2020

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