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Background and Objectives: Tattooing is one of the leading donor deferral reasons in Australia. Until September 2020, donors were deferred from all donation types for 4 months after a tattoo. At this time, our guideline changed such that donations of plasma for further manufacture were accepted immediately, provided the tattoo was administered in a licensed or regulated Australian establishment. We examined the effects of this change. Materials and Methods: Donors with a tattoo deferral in the 2 years before or after the guideline change were identified and followed up until 3 November 2022. Between the two periods, we compared blood‐borne virus (BBV) incidence, donor return, and the number of donors and donations regained after deferral. Results: The incidence of BBV infection in donors after a tattoo deferral was zero in both periods. To exceed a residual risk of 1 in 1 million for hepatitis C virus, 190 donors would need to be infected yearly from a tattoo. Donors returned to donate significantly faster after the change (median return 85 days compared with 278 days). An extra 187 donations per 10,000 person‐years of observation were gained, yielding a total of 44,674 additional plasma donations nationally 0–4 months after getting a tattoo. Conclusion: Allowing plasma donations immediately post‐tattoo resulted in a substantial donation gain with no adverse safety effect. Lifeblood subsequently reduced the deferral for transfusible component donations to 7 days for tattoos in Australian licensed/regulated establishments. [ABSTRACT FROM AUTHOR]

This paper traces the temporal tactics of continually renewed coloniality—where some impasses are made to appear insurmountable while others demand swift solutions—in relation to housing and mining at Borroloola in Australia's Northern Territory. Distinct policy and regulatory regimes encourage analyses that set housing and mining apart. Yet together they signal the settler state's simultaneous remedial and extractive orientations to remote Aboriginal communities. Mining leeches into housing, and housing is a promise extracted from late liberal recognition, for community members forced to wait for promised amenities while fighting for long‐term environmental protections. The analysis demonstrates the central significance of temporal control to settler colonialism: by selectively deferring action; by producing the appearance of actions that are not actually taken; and by intervening to expedite processes that serve the interests of extractive capital. We argue that the confection of intermittent urgency to intervene is a key feature of the deferrals enacted by Australian settler governance, as it rations remedial solutions and displaces harms into mortgaged futures. [ABSTRACT FROM AUTHOR]

Background: Blood donation is an essential and most important part of the health care system across the world. It becomes necessary to know the root cause of individuals who are willing to donate the blood but deferred on some grounds. Aim and Objectives: The aim of this study is analysis of such deferrals so as to promote voluntary blood donation practice in our health-care system. The objectives of this study are to promote voluntary blood donation, provide safe blood and blood components/products to the recipients, ensure the safety and well-being of blood donors and make strategies to retain already motivated but deferred donors. Materials and Methods: A prospective observational study was done during the period January 2021-December 2021 at blood center of S.B.K.S. MI & RC, Dhiraj Hospital, Vadodara. All individuals willing for whole blood donation were subjected to detailed history taking and general physical examination and were either accepted or denied for blood donation using the standard blood donor guidelines. Pre-donation deferred individuals and their data were then thoroughly analyzed. Results: A total of 2168 individuals reported at blood center for whole blood donation out of which 311 donors (14.34%) were deferred. Of all deferred donors, male-to-female ratio of deferral found out to be 4.02:1. Two hundred and forty-nine deferrals (80.06%) were males while 62 deferrals (19.94%) were females. Two hundred and seventy-two deferrals (12.54%) were deferred temporarily while 39 deferrals (1.79%) were permanent. Youngest deferred donor was aged 18 years while the eldest was 59 years. Low hemoglobin cases were 134 making it 43.09% of all reasons of deferring a pre-donation whole blood donor. Conclusion: Low hemoglobin (<12.5 gm%) was the leading cause of deferrals accounting for 43.09%. The majority of the deferrals were temporary where the cause can be treated or eliminated. Such donors need to be remotivated and bring them back to the donor pool so that maximum blood donation which indeed is a life-saving measure can be promoted. Furthermore, the analysis done by doing such study can help to promote the blood donation on a large scale and not only saving many lives but also create awareness among the society. [ABSTRACT FROM AUTHOR]

Background: Patients, whose non-emergency cardiac procedure was postponed during the COVID-19 pandemic, have shown signs of disease progression in the short term. Data on the long-term effects are currently lacking. Aim: To assess outcomes through 3 years following deferral. Methods: This retrospective, single-center analysis includes consecutive patients whose non-emergency cardiovascular intervention was postponed during the first COVID-19-related lockdown (March 19 to April 30, 2020). Outcomes over 36 months post-procedure were analyzed and compared to a seasonal control group undergoing non-emergency intervention in 2019 as scheduled (n = 214). The primary endpoint was a composite of emergency cardiovascular hospitalization and death. Additionally, NT-proBNP levels were analyzed. Results: The combined endpoint occurred in 60 of 178 patients (33.7%) whose non-emergency transcatheter heart valve intervention, rhythmological procedure, or left heart catheterization was postponed. Primary endpoint events did not occur more frequently in the study group during the 36-month follow-up (p = 0.402), but within the first 24 months post-procedure (HR 1.77, 95% CI 1.20–2.60, p = 0.003). Deferred patients affected by an event in the postprocedural 24 months had significantly higher NT-proBNP levels at the time of intervention (p < 0.001) (AUC 0.768, p = 0.003, optimum cut-off 808.5 pg/ml, sensitivity 84.2%, specificity 65.8%) and thereafter (p < 0.001). Conclusion: Deferral of non-emergency cardiovascular interventions is associated with poor outcomes up to 24 months post-procedure. Adverse effects affect patients who develop signs of acute heart failure, as indicated by NT-proBNP, prior to treatment. These findings could help improve resource allocation in times of limited capacity. [ABSTRACT FROM AUTHOR]

Despite guideline-based recommendation of the interchangeable use of instantaneous wave-free ratio (iFR) and fractional flow reserve (FFR) to guide revascularization decision-making, iFR/FFR could demonstrate different physiological or clinical outcomes in some specific patient or lesion subsets. Therefore, we sought to investigate the impact of difference between iFR and FFR-guided revascularization decision-making on clinical outcomes in patients with left main disease (LMD). In this international multicenter registry of LMD with physiological interrogation, we identified 275 patients in whom physiological assessment was performed with both iFR/FFR. Major adverse cardiovascular event (MACE) was defined as a composite of death, non-fatal myocardial infarction, and ischemia-driven target lesion revascularization. The receiver-operating characteristic analysis was performed for both iFR/FFR to predict MACE in respective patients in whom revascularization was deferred and performed. In 153 patients of revascularization deferral, MACE occurred in 17.0% patients. The optimal cut-off values of iFR and FFR to predict MACE were 0.88 (specificity:0.74; sensitivity:0.65) and 0.76 (specificity:0.81; sensitivity:0.46), respectively. The area under the curve (AUC) was significantly higher for iFR than FFR (0.74; 95%CI 0.62–0.85 vs. 0.62; 95%CI 0.48–0.75; p = 0.012). In 122 patients of coronary revascularization, MACE occurred in 13.1% patients. The optimal cut-off values of iFR and FFR were 0.92 (specificity:0.93; sensitivity:0.25) and 0.81 (specificity:0.047; sensitivity:1.00), respectively. The AUCs were not significantly different between iFR and FFR (0.57; 95%CI 0.40–0.73 vs. 0.46; 95%CI 0.31–0.61; p = 0.43). While neither baseline iFR nor FFR was predictive of MACE in patients in whom revascularization was performed, iFR-guided deferral seemed to be safer than FFR-guided deferral. Impact of Physiological Assessment with iFR and FFR on Clinical Outcomes of Patients with LMD. In the present study, physiological assessment, both with iFR and FFR, provided a high predictability of adverse cardiovascular event in LMD patients with revascularization deferral. Furthermore, the iFR-guided deferral strategy was safer as compared to FFR. Conversely, in patients in whom revascularization was performed for LMD, neither iFR nor FFR was predictive of cardiovascular event. AUC: area under the curve; FFR: fractional flow reserve; iFR: instantaneous wave-free ratio; LMD: left main coronary artery disease. [ABSTRACT FROM AUTHOR]

Torn between desire and hope, patience and impatience, those waiting for change in Morocco have, since independence, been articulating their rejection of the way the queues of dignity and social justice are getting intolerably static and crowded. This article reasons with cultural and socio-political gradations of waiting in the Muslim and Moroccan tradition to discuss how the dynamics of waiting and not waiting reflect the poor people's methods of tolerating or challenging the prevailing truth. We theoretically and empirically make sense of the way political stagnancy and social nothingness culminate into what we call a state of (asitism) or (as-it-is-ism), a proponent as it were of obdurate stagnancy, deferral of personal and collective expectations, and persistence of social plights and economic ills, that are continuously informed and challenged by waiting and non-waiting protocols. To get to grips with asitism as a conceptual tool and ontological phenomenon, this article takes into consideration how and why the subjects revolt, whether it be by seeking migration opportunities to Europe; by illegally crossing the borders; or by otherwise expressing their denunciation of the way politicians seek to dupe them into more waiting. However, even when they refuse to wait for the promises politicians make to be verified as truthful or fake by not taking part in the elections or by boycotting a particular party, we contend that they simply deploy the time they have for a different wait, hence re-organising themselves in a different queuing order. [ABSTRACT FROM AUTHOR]

Background and Objectives: In addition to mandatory testing of blood donations, the deferral of donors in the case of various sexual and non‐sexual risk exposures ensures the safety of blood products in Germany. The study aimed to quantify non‐disclosure of non‐sexual risk exposures, as no data are available so far. Materials and Methods: We conducted an anonymous online survey among whole‐blood donors with successful donations between January and March 2020. Data on travel to countries with endemic malaria, recent mild or febrile infections, tattoos or piercings and drug use were collected. We analysed non‐compliance in relation to donor demographics by multivariable analyses. Results: Altogether, 5.4% of the donors were non‐compliant. Non‐disclosure was highest for mild infection with 3.3% of donors, followed by febrile infections (1.4%), travel to malaria endemic countries (0.7%) and body modifications (0.5%). Intravenous drug use was negligible in our study population. Age was a predictor for all investigated risks, with higher prevalence in younger age groups. Prevalence ratios for non‐disclosure of body modifications and mild infection were higher in females than males. Donation in blood establishments with mobile services was associated with higher non‐disclosure of mild infections. Conclusion: The considerable degree of non‐compliance in some donor groups reflects the prevalence of risk factors in the underlying population (e.g., body modification) as well as probable tendency to socially desirable responding. Donor education should not focus exclusively on sexual risk behaviour, as undisclosed non‐sexual exposures may bear risks for recipients and donors. [ABSTRACT FROM AUTHOR]

As the university student body becomes more diversified and students' lives less linear, student retention carries increased importance for universities, including the conversion of deferrers and the re-enrolment of leave-taking students. This paper is based on a broader research project which explored national patterns of deferral and leave of absence in Australia and the policies and strategies for re-engaging the students who defer or take leave. Through a mixed research design, the study explores the extent to which students are positioned at the centre of deferral and leave of absence policy, informed by relationship marketing concepts. This study suggests that many universities have moved towards greater consideration of student perspectives and individualised approaches to building a trustworthy and supportive relationship with deferral and leave-taking students, based on data analytics of individual students' information and circumstances. Despite such efforts, there remain both limitations and tensions within these approaches. [ABSTRACT FROM AUTHOR]

Received: 2023/09/12; Revised: 2024/02/15; Accepted: 2024/03/04; Published online: 2024/03/26 How To Cite: Moradkhani, Fardin (2024). Desuetude principles in the constitution (identification of a concept), Comparative Study on Islamic and Western Law, 11(1), 161-185. doi.org/10.22091/CSIW.2024.9865.2455 Published by: University of Qom © The Author(s) Article type: Research The constitution as a key concept in the knowledge of law and constitutional law has many complexities and subtleties and many theories have been formed regarding it. This fundamental document is written to be the basis of the government's actions and to protect the people's rights, but sometimes it happens that its principle or principles are forgotten and even though they exist in the text of the constitution, they may remain unimplemented for decades. These principles are called unimplemented principles of the constitution or desuetude principle of the constitution in the theories of constitutional law. This article seeks to analyze this concept in the constitutional theory with a descriptive-analytical method. In this article, while defining this concept and the causes of its emergence, it has been defined the boundaries of this concept with other concepts such as abandoned and abrogate principles, deferral principles, atrophy principles. Also, one of the most important issues related to desuetude principles, i.e. informal amendment of the constitution, has been addressed. [ABSTRACT FROM AUTHOR]

Background and Objectives: Systematically measuring pre‐donation haemoglobin (Hb) levels might be overly cautious for apheresis plasma donation, since plasmapheresis entails a small loss of red blood cells. We explored the association between the frequency of apheresis plasma donation and capillary blood Hb levels. Materials and Methods: This retrospective cohort study included donors who gave apheresis plasma at least twice between 24 October 2020 and 23 October 2022 in Québec, Canada. Results were stratified by sex and analysed with linear repeated‐measure mixed models with random intercepts. Results: In total, 9535 men (mean age = 46.7 years) and 9409 women (mean age = 41.1 years) made ≥2, but no more than 16 apheresis plasma donations. Over an average of 9.2 months of observation, men maintained Hb levels well above the Hb deferral threshold, and their Hb levels decreased by only 0.17 g/dL between the 1st and 15th donation return (p < 0.0001). Over an average of 9.0 months of observation, women also maintained adequate Hb levels, and their Hb levels decreased by 0.08 g/dL between the 1st and 15th donation return. Conclusion: The frequency of apheresis plasma donation was not associated with clinically meaningful changes in Hb levels, neither in men nor in women. This evidence questions the relevance of systematically monitoring Hb for apheresis plasma donation, at least for donation frequencies of ≤7–8 times per year. However, an adverse impact of plasmapheresis on Hb levels cannot be ruled out for individuals donating more frequently or for longer than ~9 months. [ABSTRACT FROM AUTHOR]

Background: Blood collection agencies (BCAs) hosting stool (fecal or poo) donor programs report high rates of donor deferral. However, the impact of deferral on willing donors, in terms of personal well‐being and future engagement with BCAs, remains unexplored. Accordingly, we surveyed those attempting to donate intestinal microbiota about their experience of being ineligible. Study Design and Methods: A total of 196 potential stool donors from Australia's BCA (>90% blood/blood product donors) completed the first stage of eligibility screening and then an online survey once notified of their ineligibility. Respondents reported motives for donating, perceptions of screening and improvements needed, experience of being told they are ineligible, and their feelings about this. Results: Over 80% of participants were ineligible to donate. Of those ineligible, 58% did not know why they were ineligible resulting in potentially future eligible donors being permanently lost. Motives (>5%) included helping others, being a human substance donor, understanding benefits, curiosity/novelty, and helping science/research. Participants identified they needed clear and timely information during screening and a specific reason for their ineligibility. Participants commonly experienced disappointment, confusion, and calm in response to being ineligible. Discussion: BCAs need strategies to mitigate the disappointment of ineligible donors, maintain satisfaction with BCAs, and preserve donor identity since many ineligible donors give multiple human substances. BCAs should provide more information about eligibility criteria during early screening stages to reduce disappointment and give personalized information about ineligibility to resolve the confusion. Offering alternative opportunities to give may reduce disappointment and increase ineligible donor engagement. [ABSTRACT FROM AUTHOR]

Kathrine M Neuman Johnsen,1,2 Karin Magnussen,3 Christian Erstad,3 Sadaf Nabi Bhatti,4 Lise Sofie H Nissen-Meyer2 1Center for Laboratory Medicine and Blood Bank, Østfold Hospital Trust, Grålum, Norway; 2Department of Immunology, Oslo University Hospital, Oslo, Norway; 3Department of Immunology and Transfusion Medicine, Innlandet Hospital Trust, Lillehammer, Norway; 4Department of Immunology and Transfusion Medicine, Akershus University Hospital, Lørenskog, NorwayCorrespondence: Kathrine M Neuman Johnsen, Østfold Hospital Trust, P.O. Box 300, Grålum, 1714, Norway, Tel +47 669868410 ; +4796090859, Email Kathrine.M.Neuman.Johnsen@so-hf.noPurpose: In Norway, blood donors using antihypertensive medication were deferred until 2015. Following revision of the national directive, these donors could be allowed, providing stable dose for at least 3 months, adequate blood pressure control and no adverse effects caused by the therapy. The new practice was evaluated by a quality study where the major aim was to establish whether donations from blood donors on antihypertensive medication pose a risk to the donor. The risk was assessed by counting the number and categorizing the adverse events related to blood donation. In addition, the quantitative effect of including these donors was calculated.Subjects and Methods: In this retrospective quality study, blood donors on antihypertensive therapy were recruited from four different blood centers to fill out a questionnaire. A total of 265 donors answered questions regarding their health status, type of medication used, and adverse events connected to blood donation both before and after starting the therapy.Results: No severe adverse events were observed in donors on antihypertensive medications. The amount of mild adverse events, as exhibited by only 7 persons (0.46%) in this donor population, was the same as for donors without hypertensive treatment.Conclusion: Blood donation from persons on antihypertensive therapy poses no extra risk of severe adverse events, given the use of screening criteria to identify and bleed only low-risk donors.Keywords: donor safety, hemovigilance, hypertension, deferral

Background: Today, the COVID19 pandemic is one of the most important health system challenges in the world, which doesn’t have specific treatment yet. It includes a wide range of respiratory and non-respiratory signs and symptoms, that lead to hospitalization and intensive care units. Methods: In this study, 78 patients in two groups of 39 patients were included. The case group included 39 COVID19 patients who had specified sign in CT scans and factors of viral infection, high serum ferritin, increased inflammatory factor in the blood. There were two intervention groups (receiving deferoxamine and vitamin C) and the control group (receiving only official protocol drugs of the country). All patients were admitted to the ICU of Shohada-e-Tajrish Hospital and underwent complete cardiorespiratory monitoring. All changes in Spo2, hemodynamics, serum ferritin and CRP were recorded before the study. Results: This study presented that improved patient had lower ferritin levels than those who were still ill. In addition, prescribing deferoxamine as an adjunct to vitamin C can prevent cytokine storms that was effective for improving the patients with COVID19. Conclusion: In conclusion. According to the role of deferoxamine and vitamin C in significantly reducing inflammatory factors of ferritin and CRP, they can be used as an adjunctive therapy in patients with COVID19.

Background and aim: Blood transfusion is an essential therapeutic procedure. Donors are deferred for various reasons. Knowledge about deferral rate and causes will guide in maintenance of good donor data pool recruitment later. This study was done to analyse the donor deferral rates and to estimate the retrieval rate of temporarily deferred donors. Materials and Methods: A cross-sectional descriptive study was conducted at our blood bank attached to tertiary care hospital for a period of one year. Donors were screened according to SOP of Blood Bank (As per donor’s selection criteria laid down by Drugs and Cosmetics Act, 1999) and various deferral rates were estimated. Temporarily deferred donors were recalled back to donate later and the percentage of qualified donors was estimated. Results : Among the 8577 registered blood donors, 376 (4.4%) were deferred and 8201 (95.6%) were eligible. Deferral rate was 4.4% (376 donors) and majority were voluntary donors 57% (214 donors) with a high female preponderance 33.75% (81 donors). Majority 70% (263 donors) were temporarily deferred for low body-weight 14.3% (54 donors) and anaemia12.5% (47 donors). Out of 263 voluntary temporarily deferred donors, 59% (156 donors) returned for donation and 71% (111 donors) successfully donated on retrieval at a later date. Conclusion: This study upholds that voluntary non-remunerated blood donation is the source of safest blood supply in transfusion medicine. It is important to determine the rate and causes of deferral to guide the recruitment and retention of healthy donor pool. Thus “Educate, Motivate and Treat” forms the basis of safe and affordable blood supply to cater the growing demands. [ABSTRACT FROM AUTHOR]

Donating blood (components) is considered a "good deed," especially in voluntary, nonremunerated contexts where blood is donated for unknown recipients. For donor and recipient safety, blood banks apply deferral criteria. Deferred donors are less likely to return for future donations. Based on theory (e.g., on emotion, habit, and identity) and practice, several methods have been suggested to encourage return after deferral, yet few of these methods have been tested in rigorous study designs, or in the field. In this study, we therefore investigated whether offering an alternative "good deed" or providing additional information about deferral would increase donor return. Results of a randomized controlled field trial at 10 Dutch blood donation centers showed that offering alternative good deeds after deferral did not significantly increase donor return, while providing additional information did increase whole blood donor return. This suggests that additional information contributes to the continuation of pro-social behavior. [ABSTRACT FROM AUTHOR]

This article argues that Leo Strauss gives voice to a twentieth-century Jewish theology of the absence of redemption. Using the term "political theology" to characterize Strauss's thought is unexpected. But this is only surprising because the reception of Strauss remains ensnared with that of Carl Schmitt. The first and last task of this article is to disentangle Strauss from Schmitt. In between the opening and closing frames of separating Strauss from Schmitt, the article fleshes out three points about the political theology of the absence of redemption, each of which brings Strauss into conversation with one of his German-Jewish contemporaries. These points and Strauss's conversation partners are: 1. the rejection of Christian triumphalism: Franz Rosenzweig; 2. deferral and the possibility of justice: Gershom Scholem; and 3. martyrdom, morality and the seriousness of life: Fritz Baer. The conclusion considers three ways in which a Jewish political theology of the absence of redemption might begin to dislodge Schmitt's hold on the category of "political theology." [ABSTRACT FROM AUTHOR]

When choosing a voluntary blood donor (VBD), it is important to ensure the donor health, and at the same time to produce a quality and safe blood product. The donor selection process leads to donor rejection related to their current health condition. The aim of this study was to determine gender differences in VBDs, to examine the reasons for their rejection, and to determine the share of permanently and temporarily deferred VBD, especially due to low hemoglobin levels. The research was conducted in eastern Croatia in the 2014 to 2018 period. The study included 144,041 blood donations from a total of 80,418 VBDs, of which 83.3% of donations were from male VBDs and 16.7% from female VBDs. There were 11.46% of temporarily deferred and permanently rejected donors. Out of all temporarily deferred donors and possible reasons for deferral, the largest share of deferrals referred to a reduced hemoglobin level, which accounted for 54% in female VBD and 46% in male VBD. Female VBDs made up to one-third of total VBDs and account for one-sixth of total blood donations. Low hemoglobin was the most common reason for VBD deferral. Gender and age are related to blood hemoglobin levels in rejected and accepted donors. Female VBDs represent a potential reservoir for increasing the total number of VBDs.

INTRODUCTION: The regulations in India mandate a blanket deferral period of 12 months for donors from the time of acquiring a tattoo. The rationale is that using nonsterile needles, the same dyes for many persons, and other unhygienic practices result in the transmission of blood-borne infections. However, currently, autoclavable tattoo equipment, professional tattoo gun, single-use dye, and needle for tattooing have come up and are known to be devoid of the risks mentioned above. Hence, this study was designed to assess if the seroprevalence of transfusion-transmitted infections (TTIs) among tattooed blood donors was higher than in other nontattooed donors. METHODOLOGY: This cross-sectional comparative study was conducted in the Department of Transfusion Medicine at the tertiary care teaching hospital in Pondicherry from September 2017 to May 2019. The study group included blood donors in the age group of 18–60 years with one or more tattoos, and the control group was chosen among blood donors of the same age without a tattoo. The sampling technique was consecutive. The serological prevalence of the two groups was compared for HIV, hepatitis B virus, hepatitis C virus, Syphilis, and Malaria. RESULTS: A total of 368 donors were recruited for the study, 184 donors with tattoos and 184 donors without a tattoo. The detected seroprevalence of TTI among the tattooed and nontattooed groups was 3.8% and 4.3%, respectively. There was no significant association found between tattooing and seroprevalence of TTI. About 60% of the ones who got a tattoo had obtained it from a licensed tattoo parlor. CONCLUSION: We found that the seroprevalence of TTI among tattooed donors was similar to that of nontattooed donors. However, the seroprevalence among donors who had undergone more than one tattooing experience was higher than those who had a single tattooing event.

ABSTRACT To verify if strategies to reduce the height of Marandu grass pasture at beginning of the deferral period change intake and metabolic parameters in sheep during the dry season, 18 crossbred females, ½ Dorper + ½ Santa Inês were used, distributed in 9 Marandu grass paddock handles to 3 drawdown strategies at the beginning of deferral period: 1) maintenance of grass with 15cm for 5 months before deferral start (15/15cm); 2) maintenance of marandu grass with 25 cm for 5 months, but at the beginning of deferral it was reduced to 15cm (25/15cm); 3) maintenance of 35 cm grass for 5 months, but at the beginning of deferral it was reduced to 15cm (35/15cm). The experiment was conducted in a completely randomized design (CRD), with 6 repetitions and repeated measures over time. Strategies to reduce the height of Marandu grass pasture, at the beginning of the deferral period, do not change nutrient intake and energy and protein metabolism. However, changes occurring in the pasture during the dry season alter these variables, and deferral is an interesting strategy to be used for forage production in winter, however, to optimize its use, it is necessary to use supplementation with concentrated rich in fermentable carbohydrates.

• First time and young donors were the most frequent plateletpheresis deferrals. • The leading cause for deferral was elevated alanine transaminase. • In female, first-time donors, abnormal haematology should be noted. In China, the platelet donation interval is 14 days. The eligibility criterion of plateletpheresis donors (PD) is more stringent than that of whole blood donors, so the deferral causes are very complicated. However, the deferral prevalence and causes among PDs are not well known in China. To analyse the deferral prevalence and influencing factors during pre-donation among PDs in a blood centre in Eastern China. From December 26, 2020 to December 25, 2021, all data of potential PDs during pre-donation were extracted from the register system and collected using Microsoft Excel. The number of deferred visits and the corresponding causes were retrospectively analysed, and the re-donation rate of deferred donors was calculated. A total of 19,762 visits were included in the study. Of these 17,847 (90.3%) donated platelets successfully and 1915 (9.7%) were deferred. The prevalence of deferrals was high among those less than 35 years old (p < 0.05) and first-time donors (p = 0). The leading cause for deferral was elevated alanine transaminase (51.4%) followed by abnormal haematological parameters (37.15%). High white blood cell count was the first deferral factor (26.9%) in abnormal haematological parameters. In more than 2 ineligible items, low haemoglobin and haematocrit simultaneously were dominant (58.3%). The re-donation rate of repeat donors (65.4%) was higher than that of first-time donors (19.3%) (p = 0). The deferral prevalence in Chinese plateletpheresis donors was not high. First-time and young donors were more frequently deferred. The repeat donors should be of concern, especially with abnormal haematological parameters. [ABSTRACT FROM AUTHOR]

Background: Iron supplementation (IS) improves blood donors' iron stores and allows more frequent blood donation. Understanding the accuracy of self‐reported IS is helpful for potential application of IS practices to donor eligibility or donation intervals. Methods: Successful whole blood and red cell apheresis donors completed a survey at donation on the use of select dietary supplements. Respondents reporting use of either iron pills (IP) or multivitamins (MV) were invited by email to complete a similar follow‐up survey 6–8 weeks later and to provide the quantitative iron content of IS by referring the donor to the pill bottle label. Consistency between baseline and follow‐up responses was assessed overall and by pill type and demographic variables. Results: Of 2444 donors answering the baseline survey, 40% (978) reported MV or IP at donation, 354 of whom completed the follow‐up survey. A majority of survey respondents (56%–61%) reported taking iron across the two surveys, and 21%–24% took MV but were uncertain if their pills contained iron. Of 215 reporting IS at baseline, overall concordance at follow‐up was 68% and was higher for donors who were female, ≥50‐years old, and taking iron as an iron pill rather than in a multivitamin. Conclusion: Consistency of donor responses may be insufficient for use in guiding donor eligibility. Referring donors to their pill bottles was unsuccessful in improving the high frequency of uncertain responses. Incorporating IS into donor eligibility determinations is a complex endeavor that will benefit from careful planning and from post‐implementation monitoring. [ABSTRACT FROM AUTHOR]

The Bharatiya Janata Party won the 2014 parliamentary elections in India, popularising the slogan 'Achhe din aane wale hai' ('Good days are coming'). Even as the good days remained elusive, in 2019, the party won the popular vote again, with an additional promise of culling out putative 'infiltrators' from India by announcing 'NRC aane wala hai' ('NRC is coming'). Drawing on ethnographic research carried out between 2016 and 2019 in a largely Muslim working-class neighbourhood next to one of Asia's largest garbage dumps in Mumbai, this article attempts to grasp the force of the state through its affective deferral by examining this aane wala hai form of governance – the forever-deferred, the always-arriving, the ready-to-strike – that is predicated upon weaponising deferral into a tactic of governance. [ABSTRACT FROM AUTHOR]

This essay proposes that understanding a text in narrative terms is based on the reverse causality of what it calls the narrative unconscious. The argument revisits literary and critical treatments of retrospection as a phenomenon of narrative temporality. It considers retrospection from a thematic angle, from the cognitive perspective of mind time, and from a reader-response motivation to fill gaps in the story, arriving at a necessity to postulate "invisible" reverse causality. The backward logic of the narrative unconscious, defined here as consolidation, works hand in hand with the conscious, forward-oriented operation of narrative thinking that appears to us as cumulative and anticipatory. In other words, narrative thinking or narrative processing oscillates between the forward direction of anticipation and backward direction of consolidation. Although we do not have access to the anti-intuitive workings of reverse causality, we can thematize this oscillation on a performative level as the interplay between the narrator's and narratee's perspectives, which are looked at collectively as the two foci of narrative consciousness. Finally, and while leaving the important question of practical application still open, the article considers the relevance of this supposition to the literary field of narratology and suggests that the concept of the narrative unconscious is a productive way to explain the aesthetic narrative effects of "oscillatory" and affective nature. [ABSTRACT FROM AUTHOR]

Objectives: Monitoring of frozen section diagnostic performance provides an important quality improvement measure.Methods: Surgical specimens involving a frozen section diagnosis over a 3-year period were retrospectively reviewed. Glass slides were reviewed on cases with discordance. Discordance and deferral rates were calculated.Results: Of 3,675 frozen section diagnoses included, 96 (2.7%) were discordant with the final diagnosis. Additionally, 114 frozen section diagnoses (3.1%) were deferred. The organ-specific discordance rates were lowest in breast and genitourinary specimens and highest for pancreas, lymph node, and gynecologic specimens. Deferral rates were highest in musculoskeletal, breast, and hepatobiliary cases and lowest in thyroid, parathyroid, and neuropathology cases. Discordance was explained by block-sampling error (45%), specimen-sampling error (27%), or interpretation error (27%). Discordant frozen section diagnoses from gynecologic specimens were responsible for 81% of specimen-sampling errors; frozen section diagnoses of lymph nodes, head and neck, and pancreas were responsible for 54% of interpretation errors; 51% of block-sampling errors involved lymph node evaluation for metastatic carcinoma.Conclusions: Careful gross evaluation and microscopic examination of multiple levels should minimize specimen-sampling error and block-sampling error, respectively. Periodic review of accuracy and deferral rates may help reduce errors and improve the overall performance of this essential procedure. [ABSTRACT FROM AUTHOR]

This article builds on an already established understanding of Disney's Frozen as a queer text. Following Judith Butler, however, it works against a notion of 'queer' that is locatable in the intrinsic truth of plot, imagery, and character, and removed from questions of performance and narration. In taking this approach, and in keeping with the focus of this Special Edition of Humanities, the article undertakes an extensive, fine-grained reading of 'Let it Go', the stand-out song from the first Frozen film. Rather than argue for or against the idea that 'Let it Go' is a Coming Out song, issues of textual perspective and textual difference are foregrounded in a way that challenges claims to the stability of identity. The pressing question, for this article, is not whether the lead character of Frozen truly is 'out', but the possibility of fixing identity in this way, the precise nature of the reversals and antagonisms that being 'out' and 'letting it go' require in this particular text, and how such determinations might impact on a wider understanding of 'queer'. [ABSTRACT FROM AUTHOR]

BACKGROUND: Blood transfusion services work to ensure universal accessibility of safe and effective blood products for transfusion to recipients. Failure of blood donors to disclose complete truthful information before blood donation is termed as noncompliance. Noncompliance in disclosing high-risk behaviors could compromise blood safety. This study aimed to assess the prevalence rate of noncompliance and assess the predictive factors and reasons for noncompliance. MATERIALS AND METHODS: Blood donors were asked to fill a postdonation anonymous questionnaire after obtaining consent and the responses were tabulated and analyzed. Prevalence of noncompliance for both high-risk and nonhigh-risk behaviors are evaluated. Variables associated with noncompliance are analyzed by univariate analysis and logistic regression. RESULTS: Total number of participants was 3001, 2850 participants gave valid responses and included in the study. There were 94 (3.30%) responses revealing noncompliance for nonhigh-risk behavior and 30 (1.05%) responses revealing noncompliance for high-risk behavior. The predictor variables for noncompliance in reporting high-risk behavior were education and adultery. The predictor variables for noncompliance in nonhigh-risk behavior reporting were presence of comorbidity and adultery. CONCLUSION: Noncompliance in disclosure of high-risk behavior compromises blood safety. Blood donors must be ensured sufficient privacy while filling predonation questionnaire and while eliciting history any deferrable behaviors during blood donor medical examination. Privacy and confidence of the donors must be ensured either to share any postdonation information directly or anonymously to facilitate confidential unit exclusion.

Background and Objectives: Blood transfusion is a life-saving procedure and the selection of healthy blood donors is essential steps for safe blood transfusion. Proper selection of blood donors is needed for the safety of both blood donors and recipients. The aim of this study was to assess the demographic profile of blood donors and determine the frequency and reason of donor deferral in a university hospital of Nepal. Methods: This hospital-based retrospective study was carried out in the Blood Bank Unit of the tertiary care center of Nepal. Data were collected from the record book maintained in the blood bank from January 2016 to December 2020. Data were analyzed using Microsoft Office Excel 2010 for descriptive analysis. Results: A total of 3697 individuals came for blood donation during the study period; among them, 2802 (75.8%) were male and 895 (24.2%) were female. Total number of voluntary donation were 2175 (58.8%), while 1522 (41.2%) were family/replacement donation. Among all donors, 351 (9.5%) donors were deferred for different reasons. The most common cause of donor deferral was hypertension (15.0%), followed by medication (14.0%), while anemia (32.8%) was the leading cause of deferral in female donors. Out of total deferral cases, 92.6% of donors were temporary deferral, while 7.4% were deferred permanently. Conclusion: Most deferrals were temporarily due to hypertension, medication, and anemia. Awareness about these causes of deferral can increases the donor pool.

Background: During the COVID-19 pandemic, in anticipation of a demand surge for high-care hospital beds, many hospitals postponed non-emergency interventions of cardiac patients. Aim: The aim of this study was to assess the outcomes of cardiac patients whose non-emergency interventions had been deferred during the COVID-19 pandemic. Methods: Patients whose non-emergency cardiac intervention had been cancelled between March 19th and April 30th, 2020 were included (study group). All patients were considered as deferrable according to current recommendations. Patients' outcomes after 12 months were compared to a seasonal control group who underwent non-emergency interventions in 2019 as scheduled. The primary endpoint was a composite of emergency cardiovascular hospitalization and death. Secondary endpoints were levels of symptoms and cardiac biomarkers. Results: Outcomes of 193 consecutive patients in the study group were assessed and compared to 216 controls. The primary endpoint occurred significantly more often in the study group (HR 2.42, 95%CI 1.63–3.61, p < 0.001). This was driven by an increase in hospitalizations. Subgroup analyses showed that especially patients with a deferred transcatheter heart valve intervention experienced early emergency hospitalization (HR 9.55, 95%CI 3.70–24.62, p < 0.001). These findings were accompanied by more pronounced symptoms and higher biomarker levels. Conclusions: Deferral of non-emergency cardiac interventions to meet the higher demand for hospital beds during the COVID-19 crisis is associated with early emergency cardiovascular hospitalizations. Patients suffering from valvular heart disease especially constitute a vulnerable group. Consequently, our results suggest that current recommendations on the management of cardiovascular disease during the COVID-19 pandemic need revision. [ABSTRACT FROM AUTHOR]

This article examines Generative Anthropology with respect to its hypothesis that deferral is at the foundation of the human and draws out elements of GA as a lived philosophy or "spiritual discipline." To this end, it examines the centrality of different modes of deferral in the successful treatment of addiction and the rôles of both deferral and resentment in facets of human psychopathology. It uses this preliminary discussion to reopen questions regarding the idea of the human as a "danger to itself," and to ask whether our conception of intraspecific violence needs to include not merely those harms incurred by humans against others (exogenous), but those that include self-harm (autogenous), which is the leading cause of violent death in the contemporary world. It concludes by asking questions as to the potential relation between these forms of intraspecific violence and calls for further investigation into GA's "ethics of deferral." [ABSTRACT FROM AUTHOR]

Background: Intravascular ultrasound (IVUS) guides deferral decision-making regarding the left main coronary artery (LMCA) and improves outcomes. Further studies regarding coronary physiology to guide revascularization in the LMCA are needed. Our aim was to evaluate the outcome of LMCA deferral using IVUS or coronary physiology via instantaneous wave-free ratio (iFR) or fractional flow reserve (FFR)., Methods: Between January 2014 and February 2022, patients undergoing evaluation with either IVUS or coronary physiology in the LMCA were included from the SWEDEHEART registry. Exclusion criteria were a minimum luminal area < 6 mm 2 , iFR ≤ 0.89, FFR ≤ 0.80, ad hoc percutaneous coronary intervention of lesions in the LMCA, proximal left anterior descending artery, and proximal circumflex artery, planned elective revascularization, and planned valvular surgery. The primary outcome was major adverse cardiac events (MACE), defined as a composite of all-cause death, myocardial infarction, and unplanned revascularization. Kaplan-Meier event rates and multivariable Poisson regression were used for the statistical analyses., Results: Deferral of revascularization in the LMCA was performed in 1552 patients, 33.6 % with IVUS and 66.4 % with coronary physiology (iFR 11.3 % vs. FFR 55.0 %). The median follow-up time was 2.7 years. No significant difference was seen in MACE (IVUS 40.2 % vs. coronary physiology 35.5 %; adjusted RR: 1.18; 95 %CI: 0.97-1.44; p = 0.09). The results were consistent across all investigated subgroups. The rate of all-cause death was higher in the IVUS group (adjusted RR: 1.38; 95 %CI: 1.03-1.83; p = 0.03)., Conclusions: Deferral of coronary revascularization in LMCA lesions using IVUS or coronary physiology did not differ in our combined endpoint. We observed a higher risk of all-cause death using IVUS., Competing Interests: Declaration of competing interest Matthias Götberg received minor consulting fees from Abbott, Boston, Medtronic, and Philips. Karolina Berntorp, Moman A Mohammad, Sasha Koul, Troels Yndigegn, Sofia Bergman, Sammy Zwackman, Rikard Linder, Sebastian Völz, Ole Fröbert, and David Erlinge have no disclosures to report., (Copyright © 2024. Published by Elsevier B.V.)

Abstract Background Deferred stenting, despite being successful in early studies, showed no benefit in recent trials. However, these trials were testing routine deferral; not in patients with heavy thrombus burden. Results This is a prospective, Randomized Clinical Trial that included 150 patients who presented with STEMI, patients were allocated into three equal groups after the coronary angiography ± primary intervention and before stenting of the culprit lesion; group (A) included 50 patients with early deferral of stenting, group (B) included 50 patients with late deferral and group (C) included 50 patients with immediate stenting. No-reflow was significantly higher in group C, while Final TIMI flow grade 3 and MBG grade 3 were significantly higher in group A and B than group C; p = 0.019 and

BACKGROUND: Blood transfusion services work to ensure universal accessibility of safe and effective blood products for transfusion to recipients. Failure of blood donors to disclose complete truthful information before blood donation is termed as noncompliance. Noncompliance in disclosing high-risk behaviors could compromise blood safety. This study aimed to assess the prevalence rate of noncompliance and assess the predictive factors and reasons for noncompliance. MATERIALS AND METHODS: Blood donors were asked to fill a postdonation anonymous questionnaire after obtaining consent and the responses were tabulated and analyzed. Prevalence of noncompliance for both high-risk and nonhigh-risk behaviors are evaluated. Variables associated with noncompliance are analyzed by univariate analysis and logistic regression. RESULTS: Total number of participants was 3001, 2850 participants gave valid responses and included in the study. There were 94 (3.30%) responses revealing noncompliance for nonhigh-risk behavior and 30 (1.05%) responses revealing noncompliance for high-risk behavior. The predictor variables for noncompliance in reporting high-risk behavior were education and adultery. The predictor variables for noncompliance in nonhigh-risk behavior reporting were presence of comorbidity and adultery. CONCLUSION: Noncompliance in disclosure of high-risk behavior compromises blood safety. Blood donors must be ensured sufficient privacy while filling predonation questionnaire and while eliciting history any deferrable behaviors during blood donor medical examination. Privacy and confidence of the donors must be ensured either to share any postdonation information directly or anonymously to facilitate confidential unit exclusion. [ABSTRACT FROM AUTHOR]

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With ten percent of commencing students opting to defer their offer and only two-thirds of those deferrers subsequently converting their enrollment, deferral has become a significant factor affecting university enrollment and student equity. In this article, we examine the strategies that Australian universities have developed to manage deferrals and reengage students who defer based on qualitative research, including institutional surveys and in-depth interviews with senior university staff. Our research revealed broad awareness of equity issues and a range of recent, innovative practices both to minimize deferral rates and to encourage the return of deferrers through communications, engagement activities, and tailored initiatives. Nevertheless, several participants lamented a paucity of data, resources, and individualized approaches. Drawing on the findings, we argue that a better understanding of both national and institutional evidence could enable a more efficient allocation of resources and more effective and equitable university strategies. [ABSTRACT FROM AUTHOR]

Past research finds that general negativity inherent to a choice set increases deferral. In contrast, we adopt a functional perspective--linking fear to narrowed attention, negative expectations of the future, and an increased readiness for action-- and propose that incidental fear increases the likelihood of consumer choice and reduces deferral. Six studies find consistent support for this view, using both hypothetical and consequential choices. We demonstrate that relative to other emotions (disgust, sadness, hope, pride, anger) and general feelings of uncertainty, those experiencing incidental fear choose significantly more and defer less. This increased choice, however, is realized only for decisions made in the present (vs. future), when information about the deferred options is not available. Importantly, increased choice from incidental fear is mediated by increased attention and liking. Moreover, we also demonstrate that individuals with high levels of trait fear (vs. trait anger) are more likely to choose and less likely to defer. [ABSTRACT FROM AUTHOR]

The aim of the study is to evaluate the effect of induced oxidative stress by the deferoxamine (desferal) during the pregnancy on pre and post-natal developmen. One hundred twenty adult female albino rats, 3 months old, with an average weight of 175-200 g, were randomly distributed into two main groups (60 rats/group). The 1st (control group) was injected with 0.3 ml physiological salt solution / animal, and the 2nd group was injected with 100 mg deferral/kg B.W. which was given intraperitoneal once daily for three consecutive weeks (during the pregnancy period). At the end of the treatment, each group in turn was divided into two parts, each section comprising 10 animals, blood samples were collected for biochemical analysis, then uterine and fetal tissues collected to observation the studied parameters. Results showed decrease in the numbers of implantation and blastocysts. The number of alive embryos were significantly reduced with an increasing number of dead and reabsorbed embryos, malformation of fetus increase in uterine of the stressed female group compared with control group. Postnatal observations showed significant variations in postnatal development parameters. Our study suggests that the deferral injection has a pro-oxidant capacity on rats' model at dose of 100 mg/kg, and the oxidative stress plays an important role during pregnancy especially on prenatal development as well as persist up to postnatal life.

The objective of the study was to assess the current clinical practice and the attitude toward deferral of HCT/chemotherapy in patients with hematological diseases in cases of asymptomatic patients with a positive assay for SARS‐CoV‐2. In August 2021, we performed a survey among EBMT centers regarding their attitude toward deferral of HCT/chemotherapy in patients with a positive PCR result. Centers were willing to defer the planned cellular therapy for patients with asymptomatic SARS‐CoV‐2 infection without previous COVID‐19 disease, and patients who became asymptomatic after a previous COVID19 disease but persistently shed the virus, respectively, in case of high‐risk allo‐HCT (90.2%/76.9%), low‐risk allo‐HCT for malignant diseases (88.2%/83.7%), allo‐HCT for nonmalignant diseases (91.0%/91.0%), auto‐HCT (88.0%/79.8%), and CAR‐T therapy (83.1%/81.4%). The respective rates toward deferral of noncellular therapy patients was lower for both groups of patients, and varied with the primary diagnosis and anti‐malignant treatment. There is a relatively high rate of willingness to defer treatment in asymptomatic patients being positive for SARS‐CoV‐2, planned for cellular therapy, regardless of previous history of vaccination or COVID‐19. The same approach is presented for most of patients before noncellular therapy. Nevertheless, each patient should be considered individually weighting risks and benefits. [ABSTRACT FROM AUTHOR]

Choice overload is the phenomenon that increasing the number of options in an assortment makes choosing between options more difficult, sometimes leading to avoidance of making a choice. In this pre-registered online experiment (N = 501), choice overload was tested in a charitable behavior context, where participants faced a monetary donation choice. Charity organization assortment size was varied between groups, ranging between 2 and 80 options. The results indicate that there were no meaningful differences in donation likelihood between the 16 organization assortment sizes, neither for individuals with high preference certainty nor for individuals with uncertain preferences among charitable causes. Having more charitable organizations to choose from did not affect donation behavior. [ABSTRACT FROM AUTHOR]

Purpose: The aim of this study was to compare the postoperative visual outcome after a Day 0 examination in patients with two follow-ups, one between Day 3 to Day 7 and other between Day 25 to Day 30 to those with a single ophthalmic follow-up directly after 25–30 Days and to assess the safety of deferral of the first follow-up visit at 1 week. Methods: Randomized Controlled Trial was conducted at a tertiary eye care hospital, with 848 patients enrolled for the study. Patients meeting the inclusion criteria were selected. Their pre-operative and post-operative data was collected and the patients were divided into groups based on the type of cataract surgery and the postoperative follow-up protocol through randomization. Results: No significant difference was observed in the postoperative visual outcome in patients that underwent postoperative review at Day 3–7 and Day 25–30 as opposed to those that followed up directly at Day 25–30 after a mandatory Day 0 examination for all patients. Conclusion: In patients with no preexisting ocular or systemic comorbidity undergoing an uneventful cataract surgery, the postoperative follow-up visit can be safely deferred until 4 weeks, without any impact on the postoperative visual outcome, thereby conserving the available resources which can be deviated towards better eye care services.