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Objective: This scoping review is an attempt to map the literature on the prevalence, diagnosis, treatment options and prognosis of labio-gingival grooves. Introduction: Labio-gingival groove is a congenital morphologic dental anomaly, in which an infolding of the inner enamel epithelium and Hertwig's epithelial root sheath create a groove extending varying depth into root. prevalence of 6.5% in at least one incisor and mostly in maxillary central incisors. Several authors have inferred that this pathology can be either developmental or due to trauma during early childhood. This defect is often missed in routine clinical examination often leading to misdiagnosis and wrong treatment. Inclusion criteria: A thorough search among the different databases would be carried out and include articles that are case reports and observational studies pertinent to the topic and exclude review articles on the same. Methods: JBI method for scoping review will be followed. Pubmed, Scopus and Google Scholar database will be searched with no time limits. Only articles in English language will be considered. This scoping review will consider experimental/quasi-experimental, analytical and descriptive study designs including case reports and case series. Editorials, text and opinion papers will also be considered. Search management will be performed using Covidence and data of included studies will be done using a data extraction template. Obtained data will be described under the headings: prevalence, diagnosis, management and any other theme of labio-gingival groove.

Drug repurposing which identifies new therapeutic use(s) for drugs currently in use is a brand-new avenue of research interest worldwide. It circumvents the high-end monetary and time investment usually associated with contemporary drug discoveries. In the field of dentistry, recent studies in drug repurposing focuses in attaining dentin repair or reduction of bone resorption associated with apical periodontitis. Metformin, an anti-diabetic drug has shown pro-osteogenic properties. Aspirin a known anti-inflammatory agent with anticoagulant action is found to modulate the differentiation of dental pulp cells. The significant role of glycogen synthase kinase-3 inhibitors in activating the Wnt/-beta cat signaling pathway of mesenchymal pulp stem cells may pave the way to the pharmacological treatment of dental caries in near future. It is to be noted here that further preclinical and clinical studies are warranted for the regular therapeutic use of these potential drugs in clinical dentistry.