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2. Clinical characteristics and genetic profile of children with WDR72-associated distal renal tubular acidosis: a nationwide experience

Author

Deepthi, Bobbity, Krishnasamy, Sudarsan, Krishnamurthy, Shivakumar, Khandelwal, Priyanka, Sinha, Aditi, Hari, Pankaj, Jaikumar, Rohitha, Agrawal, Prajal, Saha, Abhijeet, Deepthi, R. V., Agarwal, Indira, Sinha, Rajiv, Venkatachari, Mahesh, Shah, Mehul A., Bhatt, Girish Chandra, Krishnan, Balasubramanian, Vasudevan, Anil, Bagga, Arvind, and Krishnamurthy, Sriram

Published
2024
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12. Severe acute kidney injury and difficult catheterization in a 6-month-old female infant: Answers

Author

Selvam, Abishek, Deepthi, Bobbity, Krishnasamy, Sudarsan, Dhandapany, Gunasekaran, Kumar Naredi, Bikash, and Krishnamurthy, Sriram

Subjects
Infant health services -- Usage, Acute renal failure -- Diagnosis -- Care and treatment, Urinary catheterization -- Patient outcomes, Health
Abstract

Author(s): Abishek Selvam [sup.1] , Bobbity Deepthi [sup.1] , Sudarsan Krishnasamy [sup.1] , Gunasekaran Dhandapany [sup.1] , Bikash Kumar Naredi [sup.2] , Sriram Krishnamurthy [sup.1] Author Affiliations: (1) grid.414953.e, 0000000417678301, [...]

Published
2023
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15. Hematuria and proteinuria in a 14-year-old boy on anti-tubercular treatment: Answers

Author

Sarangarajan, Sanjana, Krishnamurthy, Sriram, Deepthi, Bobbity, Annadurai, Aswini, and Srinivas, Bheemanathi Hanuman

Subjects
Proteinuria -- Diagnosis -- Case studies, Lupus -- Case studies -- Risk factors, Antitubercular agents -- Complications and side effects -- Case studies, Pediatric research, Hematuria -- Case studies -- Diagnosis, Health
Abstract

Author(s): Sanjana Sarangarajan [sup.1] , Sriram Krishnamurthy [sup.1] , Bobbity Deepthi [sup.1] , Aswini Annadurai [sup.1] , Bheemanathi Hanuman Srinivas [sup.2] Author Affiliations: (1) grid.414953.e, 0000000417678301, Department of Pediatrics, Jawaharlal [...]

Published
2022
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19. A child with tetany, convulsions, and nephrocalcinosis: Answers

Author

Karunakar, Pediredla, Krishnamurthy, Sriram, Rajavelu, Thiagarajan Narayanasamy, Deepthi, Bobbity, Thangaraj, Abarna, and Chidambaram, Aakash Chandran

Subjects
Children -- Diseases, Hypocalcemia -- Diagnosis -- Care and treatment, Kidney diseases -- Diagnosis -- Care and treatment, Health
Abstract

Author(s): Pediredla Karunakar [sup.1] , Sriram Krishnamurthy [sup.1] , Thiagarajan Narayanasamy Rajavelu [sup.1] , Bobbity Deepthi [sup.1] , Abarna Thangaraj [sup.1] , Aakash Chandran Chidambaram [sup.1] Author Affiliations: (1) grid.414953.e, [...]

Published
2021
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20. Hypokalemic paralysis and discolored teeth in a 12-year-old girl: Answers

Author

Chidambaram, Aakash Chandran, Krishnamurthy, Sriram, Deepthi, Bobbity, Thiagarajan, Narayanasamy Rajavelu, and Karunakar, Pediredla

Subjects
Familial periodic paralysis -- Diagnosis -- Care and treatment -- Tests, problems and exercises, Teeth -- Discoloration, Health
Abstract

Author(s): Aakash Chandran Chidambaram [sup.1] , Sriram Krishnamurthy [sup.1] , Bobbity Deepthi [sup.1] , Narayanasamy Rajavelu Thiagarajan [sup.1] , Pediredla Karunakar [sup.1] Author Affiliations: (1) grid.414953.e, 0000000417678301, Department of Pediatrics, [...]

Published
2021
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21. A 5-year-old girl with bony deformities and disproportionate short stature: Answers

Author

Darshan, Rangaswamy, Krishnamurthy, Sriram, Deepthi, Bobbity, Karunakar, Pediredla, Chidambaram, Aakash Chandran, and Archana, Arumugom

Subjects
Bones -- Abnormalities, Rickets -- Diagnosis -- Care and treatment, Pediatric research, Stature, Short -- Diagnosis, Health
Abstract

Author(s): Rangaswamy Darshan [sup.1] , Sriram Krishnamurthy [sup.1] , Bobbity Deepthi [sup.1] , Pediredla Karunakar [sup.1] , Aakash Chandran Chidambaram [sup.1] , Arumugom Archana [sup.1] Author Affiliations: (1) grid.414953.e, 0000000417678301, [...]

Published
2021
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26. Nephrotic syndrome in a 7-year-old girl with atypical hemolytic uremic syndrome relapse: Answers

Author

Bharathy, Palanisamy Shanmugasundaram, Krishnamurthy, Sriram, Archana, Arumugom, Karunakar, Pediredla, Deepthi, Bobbity, and Srinivas, Bheemanathi Hanuman

Subjects
Hemolytic-uremic syndrome -- Diagnosis -- Care and treatment, Nephrotic syndrome -- Diagnosis -- Care and treatment, Pediatric research, Health
Abstract

Author(s): Palanisamy Shanmugasundaram Bharathy [sup.1] , Sriram Krishnamurthy [sup.1] , Arumugom Archana [sup.1] , Pediredla Karunakar [sup.1] , Bobbity Deepthi [sup.1] , Bheemanathi Hanuman Srinivas [sup.2] Author Affiliations: (1) grid.414953.e, [...]

Published
2021
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27. The Assisted Reproductive Technology Act 2021-Provisions and Implications.

Author

Gowda, Mamatha, Deepthi, Bobbity, and Nichanahalli, Kubera Siddappa

Subjects
REPRODUCTIVE technology, FERTILIZATION in vitro, EMBRYO transfer, WELL-being
Abstract

The desire for parenthood among infertile individuals is often fulfilled by resorting to the ever-evolving Assisted Reproductive Techniques (ART). Since the birth of Durga, India's first baby born using ART in 1981, the lucrative fertility industry has grown exponentially in our country. The Government of India passed the Assisted Reproductive Technology (Regulatory) Act in 2021 to provide regulatory support to these services. The legislation offers clarity on various aspects of ART, including measures to safeguard children born through these procedures. The effective implementation of the ART Act is crucial to ensure that ART services become affordable, ethical, and socially acceptable in India. This article aims to discuss the controversies with ART services and issues that could compromise the wellbeing of children, while highlighting the provisions provided under the Act to address these. [ABSTRACT FROM AUTHOR]

Published
2024
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29. A 5-year-old boy with refractory rickets, polyuria, and hypokalemic metabolic alkalosis: Answers

Author

Chidambaram, Aakash Chandran, Krishnamurthy, Sriram, Darshith, Saragondlu Lakshminarasappa, Karunakar, Pediredla, Deepthi, Bobbity, Gunasekaran, Dhandapany, and Ramamoorthy, Jaikumar Govindaswamy

Subjects
Alkalosis -- Diagnosis -- Care and treatment, Rickets -- Causes of, Dent's disease -- Diagnosis -- Care and treatment, Urination disorders -- Causes of, Pediatric research, Health
Abstract

Author(s): Aakash Chandran Chidambaram [sup.1] , Sriram Krishnamurthy [sup.1] , Saragondlu Lakshminarasappa Darshith [sup.1] , Pediredla Karunakar [sup.1] , Bobbity Deepthi [sup.1] , Dhandapany Gunasekaran [sup.1] , Jaikumar Govindaswamy Ramamoorthy [...]

Published
2021
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32. Severe acute kidney injury in a 3-year-old boy with fever and pleural effusion: Answers

Author

Chidambaram, Aakash Chandran, Krishnamurthy, Sriram, Deepthi, Bobbity, Karunakar, Pediredla, Maulik, Kaushik, Peela, Sreeram Chandra Murthy, and Sistla, Sujatha

Subjects
Children -- Diseases, Hemolytic-uremic syndrome -- Case studies -- Diagnosis -- Complications and side effects, Acute renal failure -- Case studies -- Diagnosis -- Causes of, Pediatric research, Acute renal failure in children -- Case studies -- Diagnosis -- Causes of, Health
Abstract

Author(s): Aakash Chandran Chidambaram [sup.1] , Sriram Krishnamurthy [sup.1] , Bobbity Deepthi [sup.1] , Pediredla Karunakar [sup.1] , Kaushik Maulik [sup.1] , Sreeram Chandra Murthy Peela [sup.2] , Sujatha Sistla [...]

Published
2020
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48. Etiology, Comorbidities, and Rate of Progression of Pediatric Chronic Kidney Disease: A Cohort Study.

Author

Chidambaram, Aakash Chandran, Krishnamurthy, Sriram, Parameswaran, Sreejith, Sugumar, Kiruthiga, and Deepthi, Bobbity

Abstract

Objectives: To evaluate the etiology of pediatric chronic kidney disease (CKD), assess comorbidities, and identify rate of progression of CKD and its risk factors. Methods: Children aged 2–18 y with the Kidney Disease Improving Global Outcome (KDIGO) CKD stages 2–4 were enrolled. The etiology of CKD and its comorbidities were recorded. Kaplan–Meier survival curves were used to analyze the time to progression of CKD. Results: Of the 131 patients enrolled, CKD stages 2, 3a, 3b, and 4 constituted 62 (47.3%), 17 (13%), 26 (19.8%), and 26 (19.8%), respectively. At the last follow-up [at median (IQR) 24 (12, 30) mo], the number of children in CKD stages 2, 3a, 3b, 4 and 5 were 48 (36.6%), 16 (12.2%), 23 (17.6%), 28 (21.4%), and 16 (12.2%), respectively. Etiologies of CKD included obstructive uropathy [48 (36.6%)], chronic glomerular disease [19 (14.5%)], reflux nephropathy [14 (10.7%)] and cystic renal disease [11 (8.3%)]. Comorbidities during follow-up included CKD-MBD [87 (66.4%)], metabolic acidosis [95 (72.5%)], hypertension [88 (67.1%)], growth retardation [69 (52.6%)], and anemia [63 (48.1%)]. The number of patients with metabolic acidosis, hypertension, MBD and anemia in CKD stage 2 were 27 (56%), 26 (54.2%), 24 (50%), 15 (30%), respectively. The median (IQR) rate of decline in eGFR was 3.3 (2, 4.6) mL/min/1.73 m2/y. On multivariable analysis, proteinuria [hazard ratio 3.5 (95% CI 1.4, 8.8) p = 0.01] and hyperphosphatemia [hazard ratio 2.2 (95% CI 1.1, 4.3) p = 0.03] were significant predictors for progression of CKD. Conclusions: Even the earlier stages of CKD had significant comorbidities. The median decline in eGFR was 3.3 mL/min/1.73 m2/y. Proteinuria and hyperphosphatemia were the risk factors for progression of CKD. [ABSTRACT FROM AUTHOR]

Published
2023
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