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2. Fish consumption in mid-childhood and its relationship to neuropsychological outcomes measured in 7–9 year old children using a NUTRIMENTHE neuropsychological battery

Author

Goyens, Philippe, Carlier, Clotilde, Hoyos, Joana, Poncelet, Pascale, Dain, Elena, Martin, Françoise, Xhonneux, Annick, Langhendries, Jean-Paul, Van Hees, Jean-Noel, Rousseaux, Deborah, Closa-Monasterolo, Ricardo, Escribano, Joaquin, Luque, Veronica, Mendez, Georgina, Ferre, Natalia, Zaragoza-Jordana, Marta, Giovannini, Marcello, Riva, Enrica, Agostoni, Carlo, Scaglioni, Silvia, Verduci, Elvira, Vecchi, Fiammetta, Dionigi, Alice Re, Arrizza, Chiara, Mariani, Benedetta, Socha, Jerzy, Socha, Piotr, Stolarczyk, Anna, Szott, Katarzyna, Dobrzańska, Anna, Gruszfeld, Dariusz, Kowalik, Agnieszka, Janas, Roman, Pietraszek, Ewa, Perrin, Emmanuel, von Kries, Rüdiger, Groebe, Helfried, Reith, Anna, Hofmann, Renate, Koletzko, Berthold, Grote, Veit, Weber, Martina, Rzehak, Peter, Schiess, Sonia, Beyer, Jeannette, Fritsch, Michaela, Handel, Uschi, Pawellek, Ingrid, Verwied-Jorky, Sabine, Hannibal, Iris, Demmelmair, Hans, Haile, Gudrun, Kirchberg, Franca, Akopjan, Lusine, Campoy (PI), Cristina, Pérez, Miguel, Catena, Andrés, Torres-Espínola, Francisco J., Cristina Martínez-Zaldívar, Mª, Brandi, Pilar, Victoria Escolano-Margarit, Mª, Gudrun, Haile, Krauss-Estchmann, Susan, Décsi, Tamas, Csábi, Györgyi, Györey, Esther, Gispert-Llaurado, M., Perez-Garcia, Miguel, Escribano, J., Closa-Monasterolo, R., Luque, V., Grote, V., Weber, M., Torres-Espínola, F.J., Czech-Kowalska, J., Verduci, E., Martin, F., Piqueras, M.J., Koletzko, B., Decsi, T., Campoy, Cristina, and Emmett, P.M.

Published
2016
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3. Potential sex differences in human milk fatty acids and their association with atopic dermatitis: Results of the Ulm SPATZ health study

Author

Afd Pharmacology, Afd Chemical Biology and Drug Discovery, Pharmacology, Chemical Biology and Drug Discovery, Ordnung, Madeleine, Mank, Marko, Stahl, Bernd, Kurz, Deborah, Marosvölgyi, Tamas, Decsi, Tamas, Rothenbacher, Dietrich, Genuneit, Jon, Siziba, Linda P., Afd Pharmacology, Afd Chemical Biology and Drug Discovery, Pharmacology, Chemical Biology and Drug Discovery, Ordnung, Madeleine, Mank, Marko, Stahl, Bernd, Kurz, Deborah, Marosvölgyi, Tamas, Decsi, Tamas, Rothenbacher, Dietrich, Genuneit, Jon, and Siziba, Linda P.

Published
2023

17. Documentation of Functional and Clinical Effects of Infant Nutrition : Setting the Scene for COMMENT

Author

Koletzko, Berthold, Szajewska, Hania, Ashwell, Margaret, Shamir, Raanan, Aggett, Peter, Baerlocher, Kurt, Noakes, Paul, Braegger, Christian, Calder, Philip, Folgoso, Cristina Campoy, Colomb, Virginie, Decsi, Tamás, Domellöf, Magnus, Dupont, Christophe, Fewtrell, Mary, van Goudoever, Johannes B., Michaelsen, Kim F., Mihatsch, Walter, Guarino, Alfredo, Koletzko, Sibylle, Rigo, Jacques, Turck, Dominique, and Taminiau, Jan

Published
2012

19. Critical systematic review of the level of evidence for routine use of probiotics for reduction of mortality and prevention of necrotizing enterocolitis and sepsis in preterm infants

Author

Mihatsch, Walter A., Braegger, Christian P., Decsi, Tamas, Kolacek, Sanja, Lanzinger, Hartmut, Mayer, Benjamin, Moreno, Luis A., Pohlandt, Frank, Puntis, John, Shamir, Raanan, Stadtmüller, Ulrich, Szajewska, Hania, Turck, Dominique, and van Goudoever, Johannes B.

Published
2012
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23. Genetic variants in the FADS gene cluster are associated with arachidonic acid concentrations of human breast milk at 1.5 and 6 mo postpartum and influence the course of milk dodecanoic, tetracosenoic, and trans-9-octadecenoic acid concentrations over the duration of lactation

Author

Lattka, Eva, Rzehak, Peter, Szabó, Éva, Jakobik, Viktoria, Weck, Melanie, Weyermann, Maria, Grallert, Harald, Rothenbacher, Dietrich, Heinrich, Joachim, Brenner, Hermann, Decsi, Tamás, Illig, Thomas, and Koletzko, Berthold

Published
2011
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28. Changes in human milk fatty acid composition and maternal lifestyle-related factors over a decade: A comparison between the two Ulm Birth Cohort Studies

Author

Siziba, Linda P., Lorenz, Leonie, Brenner, Hermann, Carr, Prudence, Stahl, Bernd, Mank, Marko, Marosvölgyi, Tamas, Decsi, Tamas, Szabo, Eva, Rothenbacher, Dietrich, Genuneit, Jon, Afd Chemical Biology and Drug Discovery, Afd Pharmacology, Chemical Biology and Drug Discovery, and Pharmacology

Subjects
Nutrition and Dietetics, fatty acid composition, human milk, Medicine (miscellaneous), lactation, dietary habits
Abstract

Human milk fatty acid composition varies during lactation and is influenced by maternal diet, maternal lifestyle-related factors and genetic background. This is one of the first studies to investigate a period effect, i.e. the impact of lifestyle-related changes on human milk fatty acid composition, in two different cohorts. Lactating women were recruited from the general population a decade apart in Ulm, Germany, using similar methodology. Human milk samples collected 6 weeks post-partum were analysed [Ulm Birth Cohort Study (UBCS (2000)), n=567; Ulm SPATZ Health Study (SPATZ (2012)), n=458)]. Centred log ratio transformation was applied to fatty acid data. Principal component analysis (PCA) was used to determine study-dependent fatty acid profiles. A general linear model was used to determine the study (or period) effect on fatty acid profiles adjusting for duration of gestation, age, education, delivery mode, smoking and pre-pregnancy BMI. Two principal components were retained (PC1 and PC2). PC1 was associated with UBCS, while PC2 was associated with SPATZ. PC1 comprised high saturated fatty acids (SFAs), and low monounsaturated fatty acids (MUFAs), n-6 and n-3 long-chain polyunsaturated fatty acids (LCPUFAs). The inverse was true for PC2. Although human milk remains a source of essential fatty acids, infants could be at risk of inadequate n-3 and n-6 LCPUFA intake through human milk. The differences in the human milk fatty acid profiles also reflect changes in maternal dietary habits in the more recent cohort, which may comprise lower intakes of dietary TFAs, SFAs and higher intakes of vegetable oils.

Published
2021

32. ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition: Venous access

Author

Nicholas D. Embleton, Merit M. Tabbers, Thibault Senterre, Sissel J. Moltu, Christine Prell, Jean Charles Picaud, Olivier Goulet, Peter Szitanyi, Christian Mølgaard, Christian Braegger, Nataša Fidler Mis, Lohner Szimonetta, Anne A.M.W. van Kempen, Dieter Mesotten, Corina Hartman, Chris H. B. van den Akker, Sascha Verbruggen, Jiri Bronsky, Raanan Shamir, Arieh Riskin, Decsi Tamas, Iva Hojsak, I. Hojsak, Francis B. Mimouni, Wu Jiang, Antonia Nomayo, Magnus Domellöf, Koen F. M. Joosten, Walter A. Mihatsch, Mihalyi Krisztina, Janusz Ksiazyk, Miguel Saenz de Pipaon, Virgilio P. Carnielli, Axel R. Franz, Cristina Campoy, Mary Fewtrell, Cai Wei, Yan Weihui, Frank Jochum, Susan Hill, Sanja Kolaček, Venetia Simchowitz, Silvia Iacobelli, Berthold Koletzko, Johannes B. van Goudoever, John W. L. Puntis, Dominique Darmaun, John W L Puntis, Alexandre Lapillonne, Pediatric surgery, Pediatrics, ACS - Diabetes & metabolism, AGEM - Endocrinology, metabolism and nutrition, Amsterdam Reproduction & Development (AR&D), University of Zagreb, The General Infirmary at Leeds, Children's Hospital Zagreb, Physiopathologie des Adaptations Nutritionnelles (PhAN), Université de Nantes (UN)-Institut National de la Recherche Agronomique (INRA), ARD - Amsterdam Reproduction and Development, AGEM - Digestive immunity, Paediatric Gastroenterology, AGEM - Re-generation and cancer of the digestive system, and Neonatology

Subjects
Catheterization, Central Venous, Parenteral Nutrition, medicine.medical_specialty, Central catheter, Topical treatment, Critical Care and Intensive Care Medicine, central venous catheters, central line, central catheter, central venous access, 03 medical and health sciences, 0302 clinical medicine, 030225 pediatrics, medicine, Central Venous Catheters, Humans, Skin hygiene, 030212 general & internal medicine, Child, Intensive care medicine, ComputingMilieux_MISCELLANEOUS, Nutrition and Dietetics, business.industry, Infant, Newborn, Catheter blockage, Infant, Pediatric parenteral nutrition, Catheter-Related Infections, 3. Good health, Venous access, Parenteral nutrition, Child, Preschool, Intravenous nutrition, Child Nutritional Physiological Phenomena, business, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, Infant, Premature, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition: Venous access

Published
2018

33. Changes in human milk fatty acid composition and maternal lifestyle-related factors over a decade: A comparison between the two Ulm Birth Cohort Studies

Author

Afd Chemical Biology and Drug Discovery, Afd Pharmacology, Chemical Biology and Drug Discovery, Pharmacology, Siziba, Linda P., Lorenz, Leonie, Brenner, Hermann, Carr, Prudence, Stahl, Bernd, Mank, Marko, Marosvölgyi, Tamas, Decsi, Tamas, Szabo, Eva, Rothenbacher, Dietrich, Genuneit, Jon, Afd Chemical Biology and Drug Discovery, Afd Pharmacology, Chemical Biology and Drug Discovery, Pharmacology, Siziba, Linda P., Lorenz, Leonie, Brenner, Hermann, Carr, Prudence, Stahl, Bernd, Mank, Marko, Marosvölgyi, Tamas, Decsi, Tamas, Szabo, Eva, Rothenbacher, Dietrich, and Genuneit, Jon

Published
2021

34. Human milk fatty acid composition of allergic and non-allergic mothers: The ulm spatz health study

Author

Siziba, Linda P., Lorenz, Leonie, Stahl, Bernd, Mank, Marko, Marosvölgyi, Tamas, Decsi, Tamas, Rothenbacher, Dietrich, Genuneit, Jon, Afd Chemical Biology and Drug Discovery, Afd Pharmacology, Chemical Biology and Drug Discovery, and Pharmacology

Subjects
Nutrition and Dietetics, Human milk, Maternal allergy, Fatty acids, Food Science
Abstract

The aim of this study was to determine the differences in human milk fatty acid composition in relation to maternal allergy within a large birth cohort study using statistical methods accounting for the correlations that exist in compositional data. We observed marginal differences in human milk fatty acid composition of allergic and non-allergic mothers. However, our results do not support the hypothesis that human milk fatty acid composition is influenced by allergy or that it differs between mothers with or without allergy. Observed differences in our results between transformed and untransformed fatty acid data call for re-evaluation of previous, as well as future, studies using statistical methods appropriate for compositionality of fatty acid data.

Published
2020

37. Human milk fatty acid composition of allergic and non-allergic mothers: The ulm spatz health study

Author

Afd Chemical Biology and Drug Discovery, Afd Pharmacology, Chemical Biology and Drug Discovery, Pharmacology, Siziba, Linda P., Lorenz, Leonie, Stahl, Bernd, Mank, Marko, Marosvölgyi, Tamas, Decsi, Tamas, Rothenbacher, Dietrich, Genuneit, Jon, Afd Chemical Biology and Drug Discovery, Afd Pharmacology, Chemical Biology and Drug Discovery, Pharmacology, Siziba, Linda P., Lorenz, Leonie, Stahl, Bernd, Mank, Marko, Marosvölgyi, Tamas, Decsi, Tamas, Rothenbacher, Dietrich, and Genuneit, Jon

Published
2020

42. Re: ESPGHANʼs 2008 recommendation for early introduction of complementary foods: how good is the evidence? (Cattaneo et al. 2011)

Author

Shamir, Raanan, Koletzko, Berthold, Agostoni, Carlo, Braegger, Christian, Campoy, Cristina, Colomb, Virginie, Domellöf, Magnus, Decsi, Tamas, Fewtrell, Mary, Goulet, Olivier, Michaelsen, Kim F, Kolaček, Sanja, Mihatsch, Walter, Moreno, Luis, Puntis, John, Rigo, Jacques, Szajewska, Hania, Turck, Dominique, and van Goudoever, Johannes B.

Published
2012
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44. How far did we get? How far to go?: A European survey on postgraduate courses in evidence-based medicine

Author

Kunz, Regina, Nagy, Eva, Coppus, Sjors F.P.J., Emparanza, Jose I., Hadley, Julie, Kulier, Regina, Weinbrenner, Susanne, Arvanitis, Theodoros N., Burls, Amanda, Cabello, Juan B., Decsi, Tamas, Horvath, Andrea R., Walzak, Jacek, Kaczor, Marcin P., Zanrei, Gianni, Pierer, Karin, Schaffler, Roland, Suter, Katja, Mol, Ben W.J., and Khan, Khalid S.

Published
2009
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46. The roles of long-chain polyunsaturated fatty acids in pregnancy, lactation and infancy: review of current knowledge and consensus recommendations

Author

Koletzko, Berthold, Lien, Eric, Agostoni, Carlo, Bohles, Hansjosef, Campoy, Cristina, Cetin, Irene, Decsi, Tamas, Dudenhausen, Joachim W., Dupont, Cristophe, Forsyth, Stewart, Hoesli, Irene, Holzgreve, Wolfgang, Lapillonne, Alexandre, Putet, Guy, Secher, Niels J., Symonds, Mike, Szajewska, Hania, Willatts, Peter, and Uauy, Ricardo

Published
2008

47. The effectiveness of a clinically integrated e-learning course in evidence-based medicine: A cluster randomised controlled trial

Author

Arvanitis Theodoros N, Emparanza Jose I, Nagy Eva, Horvath Andrea R, Decsi Tamas, Meyerrose Berrit, Weinbrenner Susanne, Das Kausik, Malick Sadia, Hadley Julie, Zamora Javier, Coppus Sjors FPJ, Kulier Regina, Burls Amanda, Cabello Juan B, Kaczor Marcin, Zanrei Gianni, Pierer Karen, Stawiarz Katarzyna, Kunz Regina, Mol Ben WJ, and Khan Khalid S

Subjects
Special aspects of education, LC8-6691, Medicine
Abstract

Abstract Background To evaluate the educational effects of a clinically integrated e-learning course for teaching basic evidence-based medicine (EBM) among postgraduates compared to a traditional lecture-based course of equivalent content. Methods We conducted a cluster randomised controlled trial in the Netherlands and the UK involving postgraduate trainees in six obstetrics and gynaecology departments. Outcomes (knowledge gain and change in attitude towards EBM) were compared between the clinically integrated e-learning course (intervention) and the traditional lecture based course (control). We measured change from pre- to post-intervention scores using a validated questionnaire assessing knowledge (primary outcome) and attitudes (secondary outcome). Results There were six clusters involving teaching of 61 postgraduate trainees (28 in the intervention and 33 in the control group). The intervention group achieved slightly higher scores for knowledge gain compared to the control, but these results were not statistically significant (difference in knowledge gain: 3.5 points, 95% CI -2.7 to 9.8, p = 0.27). The attitudinal changes were similar for both groups. Conclusion A clinically integrated e-learning course was at least as effective as a traditional lecture based course and was well accepted. Being less costly than traditional teaching and allowing for more independent learning through materials that can be easily updated, there is a place for incorporating e-learning into postgraduate EBM curricula that offer on-the-job training for just-in-time learning. Trial registration Trial registration number: ACTRN12609000022268.

Published
2009
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49. Harmonising Evidence-based medicine teaching: a study of the outcomes of e-learning in five European countries

Author

Cabello Juan B, Arvanitis Theodoros N, Burls Amanda, Coppus Sjors FPJ, Emparanza Jose I, Nagy Eva, Horvath Andrea R, Decsi Tamas, Meyerrose Berrit, Weinbrenner Susanne, Hadley Julie, Kulier Regina, Kaczor Marcin, Zanrei Gianni, Pierer Karen, Stawiarz Katarzyna, Kunz Regina, Mol Ben WJ, and Khan Khalid S

Subjects
Special aspects of education, LC8-6691, Medicine
Abstract

Abstract Background We developed and evaluated the outcomes of an e-learning course for evidence based medicine (EBM) training in postgraduate medical education in different languages and settings across five European countries. Methods We measured changes in knowledge and attitudes with well-developed assessment tools before and after administration of the course. The course consisted of five e-learning modules covering acquisition (formulating a question and search of the literature), appraisal, application and implementation of findings from systematic reviews of therapeutic interventions, each with interactive audio-visual learning materials of 15 to 20 minutes duration. The modules were prepared in English, Spanish, German and Hungarian. The course was delivered to 101 students from different specialties in Germany (psychiatrists), Hungary (mixture of specialties), Spain (general medical practitioners), Switzerland (obstetricians-gynaecologists) and the UK (obstetricians-gynaecologists). We analysed changes in scores across modules and countries. Results On average across all countries, knowledge scores significantly improved from pre- to post-course for all five modules (p < 0.001). The improvements in scores were on average 1.87 points (14% of total score) for module 1, 1.81 points (26% of total score) for module 2, 1.9 points (11% of total score) for module 3, 1.9 points (12% of total score) for module 4 and 1.14 points (14% of total score) for module 5. In the country specific analysis, knowledge gain was not significant for module 4 in Spain, Switzerland and the UK, for module 3 in Spain and Switzerland and for module 2 in Spain. Compared to pre-course assessment, after completing the course participants felt more confident that they can assess research evidence and that the healthcare system in their country should have its own programme of research about clinical effectiveness. Conclusion E-learning in EBM can be harmonised for effective teaching and learning in different languages, educational settings and clinical specialties, paving the way for development of an international e-EBM course.

Published
2008
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50. A clinically integrated curriculum in Evidence-based Medicine for just-in-time learning through on-the-job training: The EU-EBM project

Author

Horvath Andrea R, Decsi Tamas, Cabello Juan B, Burls Amanda, Arvanitis Theodoros N, Weinbrenner Susanne, Kulier Regina, Emparanza Jose I, Hadley Julie, Coppus Sjors FPJ, Kaczor Marcin, Zanrei Gianni, Pierer Karin, Stawiarz Katarzyna, Kunz Regina, Mol Ben WJ, and Khan Khalid S

Subjects
Special aspects of education, LC8-6691, Medicine
Abstract

Abstract Background Over the last years key stake holders in the healthcare sector have increasingly recognised evidence based medicine (EBM) as a means to improving the quality of healthcare. However, there is considerable uncertainty about the best way to disseminate basic knowledge of EBM. As a result, huge variation in EBM educational provision, setting, duration, intensity, content, and teaching methodology exists across Europe and worldwide. Most courses for health care professionals are delivered outside the work context ('stand alone') and lack adaptation to the specific needs for EBM at the learners' workplace. Courses with modern 'adaptive' EBM teaching that employ principles of effective continuing education might fill that gap. We aimed to develop a course for post-graduate education which is clinically integrated and allows maximum flexibility for teachers and learners. Methods A group of experienced EBM teachers, clinical epidemiologists, clinicians and educationalists from institutions from eight European countries participated. We used an established methodology of curriculum development to design a clinically integrated EBM course with substantial components of e-learning. An independent European steering committee provided input into the process. Results We defined explicit learning objectives about knowledge, skills, attitudes and behaviour for the five steps of EBM. A handbook guides facilitator and learner through five modules with clinical and e-learning components. Focussed activities and targeted assignments round off the learning process, after which each module is formally assessed. Conclusion The course is learner-centred, problem-based, integrated with activities in the workplace and flexible. When successfully implemented, the course is designed to provide just-in-time learning through on-the-job-training, with the potential for teaching and learning to directly impact on practice.

Published
2007
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