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3. Collisions of solid ice in planetesimal formation

Author

Deckers, J. and Teiser, J.

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

We present collision experiments of centimetre projectiles on to decimetre targets, both made up of solid ice, at velocities of $15\,\mathrm{m\,s^{-1}}$ to $45\,\mathrm{m\,s^{-1}}$ at an average temperature of $\mathrm{T_{avg}}=255.8\pm0.7\,\mathrm{K}$. In these collisions the centimetre body gets disrupted and part of it sticks to the target. This behaviour can be observed up to an upper threshold, that depends on the projectile size, beyond which there is no mass transfer. In collisions of small particles, as produced by the disruption of the centimetre projectiles, we also find mass transfer to the target. In this way the larger body can gain mass, although the efficiency of the initial mass transfer is rather low. These collision results can be applied to planetesimal formation near the snowline, where evaporation and condensation is expected to produce solid ice. In free fall collisions at velocities up to about $7\,\mathrm{m\,s^{-1}}$, we investigated the threshold to fragmentation and coefficient of restitution of centimetre ice spheres., Comment: 7 Pages, 9 Figures

Published
2016
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8. Potential lifetime benefit of applying two-step ESC prevention strategy

Author

Van Trier, T, primary, Snaterse, M, additional, Hageman, S H J, additional, Ter Hoeve, N, additional, Sunamura, M, additional, Deckers, J, additional, Martens, F M A C, additional, Visseren, F L J, additional, Dorresteijn, J A N, additional, Scholte Op Reimer, W J M, additional, Peters, R J G, additional, and Jorstad, H T, additional

Published
2023
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12. Resolving sepsis-induced immunoparalysis via trained immunity by targeting interleukin-4 to myeloid cells.

Author

Schrijver, David P., Roring, R.J., Deckers, J., Dreu, A. de, Toner, Y.C., Prevot, G., Priem, B., Munitz, J., Nugraha, E.G., Elsas, Y. van, Azzun, A., Anbergen, T., Groh, L.A., Becker, A.M.D., Pérez-Medina, C., Oosterwijk, R.S., Novakovic, B., Moorlag, S.J.C.F.M., Jansen, A., Pickkers, P., Kox, M., Beldman, T.J., Kluza, E., Leent, M.M.T. van, Teunissen, A.J.P., Meel, R. van der, Fayad, Z.A., Joosten, L.A.B., Fisher, E.A., Merkx, M., Netea, M.G., Mulder, W.J.M., Schrijver, David P., Roring, R.J., Deckers, J., Dreu, A. de, Toner, Y.C., Prevot, G., Priem, B., Munitz, J., Nugraha, E.G., Elsas, Y. van, Azzun, A., Anbergen, T., Groh, L.A., Becker, A.M.D., Pérez-Medina, C., Oosterwijk, R.S., Novakovic, B., Moorlag, S.J.C.F.M., Jansen, A., Pickkers, P., Kox, M., Beldman, T.J., Kluza, E., Leent, M.M.T. van, Teunissen, A.J.P., Meel, R. van der, Fayad, Z.A., Joosten, L.A.B., Fisher, E.A., Merkx, M., Netea, M.G., and Mulder, W.J.M.

Abstract

01 september 2023, Item does not contain fulltext, Immunoparalysis is a compensatory and persistent anti-inflammatory response to trauma, sepsis or another serious insult, which increases the risk of opportunistic infections, morbidity and mortality. Here, we show that in cultured primary human monocytes, interleukin-4 (IL4) inhibits acute inflammation, while simultaneously inducing a long-lasting innate immune memory named trained immunity. To take advantage of this paradoxical IL4 feature in vivo, we developed a fusion protein of apolipoprotein A1 (apoA1) and IL4, which integrates into a lipid nanoparticle. In mice and non-human primates, an intravenously injected apoA1-IL4-embedding nanoparticle targets myeloid-cell-rich haematopoietic organs, in particular, the spleen and bone marrow. We subsequently demonstrate that IL4 nanotherapy resolved immunoparalysis in mice with lipopolysaccharide-induced hyperinflammation, as well as in ex vivo human sepsis models and in experimental endotoxemia. Our findings support the translational development of nanoparticle formulations of apoA1-IL4 for the treatment of patients with sepsis at risk of immunoparalysis-induced complications.

Published
2023

13. Engineering cytokine therapeutics.

Author

Deckers, J. and Deckers, J.

Subjects
Biophysical Chemistry., Radboudumc 19: Nanomedicine Internal Medicine., Radboudumc 4: lnfectious Diseases and Global Health Internal Medicine.
Published
2023

14. Intramolecular locking and coumarin insertion: a stepwise approach for TADF design.

Author

Paredis, S., Cardeynaels, T., Brebels, S., Deckers, J., Kuila, S., Lathouwers, A., Van Landeghem, M., Vandewal, K., Danos, A., Monkman, A. P., Champagne, B., and Maes, W.

Abstract

Three novel TADF (thermally activated delayed fluorescence) emitters based on the well-studied Qx-Ph-DMAC fluorophore are designed and synthesized. The photophysical properties of these materials are studied from a theoretical and experimental point of view, demonstrating the cumulative effects of multiple small modifications that combine to afford significantly improved TADF performance. First, an extra phenyl ring is added to the acceptor part of Qx-Ph-DMAC to increase the conjugation length, resulting in BQx-Ph-DMAC, which acts as an intermediate molecular structure. Next, an electron-deficient coumarin unit is incorporated to fortify the electron accepting ability, affording ChromPy-Ph-DMAC with red-shifted emission. Finally, the conjugated system is further enlarged by 'locking' the molecular structure, generating DBChromQx-DMAC with further red-shifted emission. The addition of the coumarin unit significantly impacts the charge-transfer excited state energy levels with little effect on the locally excited states, resulting in a decrease of the singlet–triplet energy gap. As a result, the two coumarin-based emitters show considerably improved TADF performance in 1 w/w% zeonex films when compared to the initial Qx-Ph-DMAC structure. 'Locking' the molecular structure further lowers the singlet–triplet energy gap, resulting in more efficient reverse intersystem crossing and increasing the contribution of TADF to the total emission. [ABSTRACT FROM AUTHOR]

Published
2023
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16. Loss of GM-CSF-dependent instruction of alveolar macrophages in COVID-19 provides a rationale for inhaled GM-CSF treatment

Author

Debeuf, N, primary, Bosteels, C, additional, Van Damme, K F A, additional, De Leeuw, E, additional, Declercq, J, additional, Maes, B, additional, Bosteels, V, additional, Hoste, L, additional, Naesens, L, additional, Deckers, J, additional, Guilliams, M, additional, Tavernier, S J, additional, and Lambrecht, B N, additional

Published
2023
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50. Building land resilience in NW Ethiopia : lessons learned from five years of overseas research collaboration

Author

Frankl, Amaury, Abate, M., Abere, T., Adgo, E., Amsalu, T., Deffersha, Habtamu Assaye, Aynalem, S., Bodé, Samuel, De Wit, Bart, Boeckx, Pascal, Deckers, J., Strubbe, Diederik, Matheve, Hans, Lemma, H., Lens, Luc, Mequanint, F., Muys, B., Nyssen, Jan, Poesen, J., Tsegaye, D., Vancampenhout, K., Verstraeten, G., Worku, G., and Wassie, A.

Subjects
Chemistry, Technology and Engineering, Land management, Earth and Environmental Sciences, Sediment yield, Soil erosion, Biology and Life Sciences, Forest ecology, Natural resources, Ecosystem
Published
2021

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