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1. Explanatory Model Monitoring to Understand the Effects of Feature Shifts on Performance

Author

Decker, Thomas, Koebler, Alexander, Lebacher, Michael, Thon, Ingo, Tresp, Volker, and Buettner, Florian

Subjects
Computer Science - Machine Learning
Abstract

Monitoring and maintaining machine learning models are among the most critical challenges in translating recent advances in the field into real-world applications. However, current monitoring methods lack the capability of provide actionable insights answering the question of why the performance of a particular model really degraded. In this work, we propose a novel approach to explain the behavior of a black-box model under feature shifts by attributing an estimated performance change to interpretable input characteristics. We refer to our method that combines concepts from Optimal Transport and Shapley Values as Explanatory Performance Estimation (XPE). We analyze the underlying assumptions and demonstrate the superiority of our approach over several baselines on different data sets across various data modalities such as images, audio, and tabular data. We also indicate how the generated results can lead to valuable insights, enabling explanatory model monitoring by revealing potential root causes for model deterioration and guiding toward actionable countermeasures., Comment: ACM SIGKDD Conference on Knowledge Discovery and Data Mining (KDD 24)

Published
2024
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2. Provably Better Explanations with Optimized Aggregation of Feature Attributions

Author

Decker, Thomas, Bhattarai, Ananta R., Gu, Jindong, Tresp, Volker, and Buettner, Florian

Subjects
Computer Science - Machine Learning, Computer Science - Artificial Intelligence, Computer Science - Computer Vision and Pattern Recognition
Abstract

Using feature attributions for post-hoc explanations is a common practice to understand and verify the predictions of opaque machine learning models. Despite the numerous techniques available, individual methods often produce inconsistent and unstable results, putting their overall reliability into question. In this work, we aim to systematically improve the quality of feature attributions by combining multiple explanations across distinct methods or their variations. For this purpose, we propose a novel approach to derive optimal convex combinations of feature attributions that yield provable improvements of desired quality criteria such as robustness or faithfulness to the model behavior. Through extensive experiments involving various model architectures and popular feature attribution techniques, we demonstrate that our combination strategy consistently outperforms individual methods and existing baselines., Comment: International Conference on Machine Learning (ICML) 2024

Published
2024

3. Does Your Model Think Like an Engineer? Explainable AI for Bearing Fault Detection with Deep Learning

Author

Decker, Thomas, Lebacher, Michael, and Tresp, Volker

Subjects
Computer Science - Machine Learning, Computer Science - Artificial Intelligence
Abstract

Deep Learning has already been successfully applied to analyze industrial sensor data in a variety of relevant use cases. However, the opaque nature of many well-performing methods poses a major obstacle for real-world deployment. Explainable AI (XAI) and especially feature attribution techniques promise to enable insights about how such models form their decision. But the plain application of such methods often fails to provide truly informative and problem-specific insights to domain experts. In this work, we focus on the specific task of detecting faults in rolling element bearings from vibration signals. We propose a novel and domain-specific feature attribution framework that allows us to evaluate how well the underlying logic of a model corresponds with expert reasoning. Utilizing the framework we are able to validate the trustworthiness and to successfully anticipate the generalization ability of different well-performing deep learning models. Our methodology demonstrates how signal processing tools can effectively be used to enhance Explainable AI techniques and acts as a template for similar problems., Comment: 2023 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP)

Published
2023
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4. Explaining Deep Neural Networks for Bearing Fault Detection with Vibration Concepts

Author

Decker, Thomas, Lebacher, Michael, and Tresp, Volker

Subjects
Computer Science - Machine Learning, Computer Science - Artificial Intelligence
Abstract

Concept-based explanation methods, such as Concept Activation Vectors, are potent means to quantify how abstract or high-level characteristics of input data influence the predictions of complex deep neural networks. However, applying them to industrial prediction problems is challenging as it is not immediately clear how to define and access appropriate concepts for individual use cases and specific data types. In this work, we investigate how to leverage established concept-based explanation techniques in the context of bearing fault detection with deep neural networks trained on vibration signals. Since bearings are prevalent in almost every rotating equipment, ensuring the reliability of intransparent fault detection models is crucial to prevent costly repairs and downtimes of industrial machinery. Our evaluations demonstrate that explaining opaque models in terms of vibration concepts enables human-comprehensible and intuitive insights about their inner workings, but the underlying assumptions need to be carefully validated first., Comment: 2023 IEEE 21st International Conference on Industrial Informatics (INDIN)

Published
2023
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5. Towards Scenario-based Safety Validation for Autonomous Trains with Deep Generative Models

Author

Decker, Thomas, Bhattarai, Ananta R., and Lebacher, Michael

Subjects
Computer Science - Machine Learning, Computer Science - Artificial Intelligence, Computer Science - Computer Vision and Pattern Recognition
Abstract

Modern AI techniques open up ever-increasing possibilities for autonomous vehicles, but how to appropriately verify the reliability of such systems remains unclear. A common approach is to conduct safety validation based on a predefined Operational Design Domain (ODD) describing specific conditions under which a system under test is required to operate properly. However, collecting sufficient realistic test cases to ensure comprehensive ODD coverage is challenging. In this paper, we report our practical experiences regarding the utility of data simulation with deep generative models for scenario-based ODD validation. We consider the specific use case of a camera-based rail-scene segmentation system designed to support autonomous train operation. We demonstrate the capabilities of semantically editing railway scenes with deep generative models to make a limited amount of test data more representative. We also show how our approach helps to analyze the degree to which a system complies with typical ODD requirements. Specifically, we focus on evaluating proper operation under different lighting and weather conditions as well as while transitioning between them., Comment: International Conference on Computer Safety, Reliability, and Security 2023

Published
2023
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6. The Thousand Faces of Explainable AI Along the Machine Learning Life Cycle: Industrial Reality and Current State of Research

Author

Decker, Thomas, Gross, Ralf, Koebler, Alexander, Lebacher, Michael, Schnitzer, Ronald, and Weber, Stefan H.

Subjects
Computer Science - Machine Learning, Computer Science - Artificial Intelligence, Computer Science - Human-Computer Interaction
Abstract

In this paper, we investigate the practical relevance of explainable artificial intelligence (XAI) with a special focus on the producing industries and relate them to the current state of academic XAI research. Our findings are based on an extensive series of interviews regarding the role and applicability of XAI along the Machine Learning (ML) lifecycle in current industrial practice and its expected relevance in the future. The interviews were conducted among a great variety of roles and key stakeholders from different industry sectors. On top of that, we outline the state of XAI research by providing a concise review of the relevant literature. This enables us to provide an encompassing overview covering the opinions of the surveyed persons as well as the current state of academic research. By comparing our interview results with the current research approaches we reveal several discrepancies. While a multitude of different XAI approaches exists, most of them are centered around the model evaluation phase and data scientists. Their versatile capabilities for other stages are currently either not sufficiently explored or not popular among practitioners. In line with existing work, our findings also confirm that more efforts are needed to enable also non-expert users' interpretation and understanding of opaque AI models with existing methods and frameworks., Comment: International Conference on Human-Computer Interaction 2023

Published
2023
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7. Physical activity levels are positively related to progression-free survival and reduced adverse events in advanced ER+ breast cancer

Author

Zimmer, Philipp, Esser, Tobias, Lueftner, Diana, Schuetz, Florian, Baumann, Freerk T., Rody, Achim, Schneeweiss, Andreas, Hartkopf, Andreas D., Decker, Thomas, Uleer, Christoph, Stoetzer, Oliver J., Foerster, Frank, Schmidt, Marcus, Mundhenke, Christoph, Steindorf, Karen, Tesch, Hans, Jackisch, Christian, Fischer, Thomas, Hanson, Sven, Kreuzeder, Julia, Guderian, Gernot, Fasching, Peter A., and Bloch, Wilhelm

Published
2024
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9. JAK-STAT signaling maintains homeostasis in T cells and macrophages

Author

Fortelny, Nikolaus, Farlik, Matthias, Fife, Victoria, Gorki, Anna-Dorothea, Lassnig, Caroline, Maurer, Barbara, Meissl, Katrin, Dolezal, Marlies, Boccuni, Laura, Ravi Sundar Jose Geetha, Aarathy, Akagha, Mojoyinola Joanna, Karjalainen, Anzhelika, Shoebridge, Stephen, Farhat, Asma, Mann, Ulrike, Jain, Rohit, Tikoo, Shweta, Zila, Nina, Esser-Skala, Wolfgang, Krausgruber, Thomas, Sitnik, Katarzyna, Penz, Thomas, Hladik, Anastasiya, Suske, Tobias, Zahalka, Sophie, Senekowitsch, Martin, Barreca, Daniele, Halbritter, Florian, Macho-Maschler, Sabine, Weninger, Wolfgang, Neubauer, Heidi A., Moriggl, Richard, Knapp, Sylvia, Sexl, Veronika, Strobl, Birgit, Decker, Thomas, Müller, Mathias, and Bock, Christoph

Published
2024
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15. Empower Individuals to Control Their Biometric Data: The New Challenge across All Sectors

Author

Decker, Thomas

Subjects
Biometric technology, Data security issue, Data security -- Methods, Cloud computing -- Safety and security measures, Information storage and retrieval -- Methods, Cyberterrorism -- Prevention
Abstract

What if your face, fingerprint, or iris was your greatest vulnerability in a cyberattack? All those parts of you that are most unique and private are now embedded in our [...]

Published
2025

19. Third International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions)

Author

Elfgen, Constanze, Leo, Cornelia, Kubik-Huch, Rahel A., Muenst, Simone, Schmidt, Noemi, Quinn, Cecily, McNally, Sorcha, van Diest, Paul J., Mann, Ritse M, Bago-Horvath, Zsuzsanna, Bernathova, Maria, Regitnig, Peter, Fuchsjäger, Michael, Schwegler-Guggemos, Daniela, Maranta, Martina, Zehbe, Sabine, Tausch, Christoph, Güth, Uwe, Fallenberg, Eva Maria, Schrading, Simone, Kothari, Ashutosh, Sonnenschein, Martin, Kampmann, Gert, Kulka, Janina, Tille, Jean-Christophe, Körner, Meike, Decker, Thomas, Lax, Sigurd F., Daniaux, Martin, Bjelic-Radisic, Vesna, Kacerovsky-Strobl, Stephanie, Condorelli, Rosaria, Gnant, Michael, and Varga, Zsuzsanna

Published
2023
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20. Efficacy, safety, and prognosis prediction in patients treated with ribociclib in combination with letrozole: Final results of phase 3b RIBECCA study in hormone receptor positive, human epidermal growth factor receptor-2 negative, locally advanced or metastatic breast cancer

Author

Fasching, Peter A., Decker, Thomas, Hartkopf, Andreas, Nusch, Arnd, Heinrich, Bernhard J., Kurbacher, Christian, Fuchs, Roswitha, Tesch, Hans, Krabisch, Petra, Huober, Jens, Kuemmel, Sherko, Brucker, Sara, Janni, Wolfgang, Schneeweiss, Andreas, Schuler, Martin, Fehm, Tanja, Lüftner, Diana, Quiering, Claudia, Voges, Claudia, Kreuzeder, Julia, and Reinisch, Mattea

Published
2024
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21. Anti-hormonal maintenance treatment with the CDK4/6 inhibitor ribociclib after 1st line chemotherapy in hormone receptor positive / HER2 negative metastatic breast cancer: A phase II trial (AMICA)

Author

Decker, Thomas, Lüdtke-Heckenkamp, Kerstin, Melnichuk, Luidmila, Hirmas, Nader, Lübbe, Kristina, Zahn, Mark-Oliver, Schmidt, Marcus, Denkert, Carsten, Lorenz, Ralf, Müller, Volkmar, Zahm, Dirk-Michael, Mundhenke, Christoph, Bauer, Stefan, Thill, Marc, Seropian, Peter, Filmann, Natalie, and Loibl, Sibylle

Published
2023
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22. Favorable impact of therapy management by an interactive eHealth system on severe adverse events in patients with hormone receptor-positive, HER2-negative locally advanced or metastatic breast cancer treated by palbociclib and endocrine therapy

Author

Harbeck, Nadia, Kates, Ronald, Schinköthe, Timo, Schumacher, Johannes, Wuerstlein, Rachel, Degenhardt, Tom, Lüftner, Diana, Räth, Philip, Hoffmann, Oliver, Lorenz, Ralf, Decker, Thomas, Reinisch, Mattea, Göhler, Thomas, Staib, Peter, Gluz, Oleg, Fasching, Peter A, and Schmidt, Marcus

Published
2023
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24. The Oncology Biomarker Discovery framework reveals cetuximab and bevacizumab response patterns in metastatic colorectal cancer

Author

Ohnmacht, Alexander J., Stahler, Arndt, Stintzing, Sebastian, Modest, Dominik P., Holch, Julian W., Westphalen, C. Benedikt, Hölzel, Linus, Schübel, Marisa K., Galhoz, Ana, Farnoud, Ali, Ud-Dean, Minhaz, Vehling-Kaiser, Ursula, Decker, Thomas, Moehler, Markus, Heinig, Matthias, Heinemann, Volker, and Menden, Michael P.

Published
2023
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25. The INFINITY study protocol: a retrospective cohort study on decision making and clinical impact of biomarker-driven precision oncology in routine clinical practice

Author

Martens, Uwe M., Schröder, Jan, Bengsch, Fee, Sellmann, Ludger, Busies, Sabine, Frank-Gleich, Stefanie, Zaiss, Matthias, Decker, Thomas, Schneeweiss, Andreas, Schuler, Martin, Grebhardt, Sina, Zacharias, Stefan, Marschner, Norbert, Kasenda, Benjamin, Potthoff, Karin, and Vannier, Corinne

Published
2023
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26. PRECYCLE: multicenter, randomized phase IV intergroup trial to evaluate the impact of eHealth-based patient-reported outcome (PRO) assessment on quality of life in patients with hormone receptor positive, HER2 negative locally advanced or metastatic breast cancer treated with palbociclib and an aromatase inhibitor or palbociclib and fulvestrant

Author

Degenhardt, Tom, Fasching, Peter A., Lüftner, Diana, Müller, Volkmar, Thomssen, Christoph, Schem, Christian, Witzel, Isabell, Decker, Thomas, Tesch, Hans, Kümmel, Sherko, Uleer, Christoph, Wuerstlein, Rachel, Hoffmann, Oliver, Warm, Mathias, Marschner, Norbert, Schinköthe, Timo, Kates, Ronald E., Schumacher, Johannes, Otremba, Burkhard, Zaiss, Matthias, Harbeck, Nadia, and Schmidt, Marcus

Published
2023
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29. Standard diametric versus volumetric early tumor shrinkage as a predictor of survival in metastatic colorectal cancer: subgroup findings of the randomized, open-label phase III trial FIRE-3 / AIO KRK-0306

Author

Hofmann, Felix O., Heinemann, Volker, D’Anastasi, Melvin, Gesenhues, Alena B., Hesse, Nina, von Weikersthal, Ludwig Fischer, Decker, Thomas, Kiani, Alexander, Moehler, Markus, Kaiser, Florian, Heintges, Tobias, Kahl, Christoph, Kullmann, Frank, Scheithauer, Werner, Link, Hartmut, Modest, Dominik P., Stintzing, Sebastian, and Holch, Julian W.

Published
2023
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34. Correction to: Second International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions).

Author

Rageth, Christoph, OFlynn, Elizabeth, Pinker, Katja, Kubik-Huch, Rahel, Mundinger, Alexander, Decker, Thomas, Tausch, Christoph, Dammann, Florian, Baltzer, Pascal, Fallenberg, Eva, Foschini, Maria, Dellas, Sophie, Knauer, Michael, Malhaire, Caroline, Sonnenschein, Martin, Boos, Andreas, Varga, Zsuzsanna, and Morris, Elizabeth

Abstract

The article Second International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions), written by Christoph J Rageth, Elizabeth AM OFlynn, Katja Pinker, Rahel A Kubik-Huch, Alexander Mundinger, Thomas Decker, Christoph Tausch, Florian Dammann, Pascal A. Baltzer, Eva Maria Fallenberg, Maria P Foschini, Sophie Dellas, Michael Knauer, Caroline Malhaire, Martin Sonnenschein, Andreas Boos, Elisabeth Morris, Zsuzsanna Varga, was originally published electronically on the publishers internet portal (currently SpringerLink) on November 30, 2018 without open access.

Published
2019

35. Second International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions).

Author

Rageth, Christoph, OFlynn, Elizabeth, Pinker, Katja, Kubik-Huch, Rahel, Mundinger, Alexander, Decker, Thomas, Tausch, Christoph, Dammann, Florian, Baltzer, Pascal, Fallenberg, Eva, Foschini, Maria, Dellas, Sophie, Knauer, Michael, Malhaire, Caroline, Sonnenschein, Martin, Boos, Andreas, Varga, Zsuzsanna, and Morris, Elizabeth

Subjects
B3 lesions, Breast, Breast surgery, Consensus, Uncertain malignant potential, Vacuum-assisted biopsy, Biopsy, Large-Core Needle, Breast Neoplasms, Carcinoma, Intraductal, Noninfiltrating, Carcinoma, Lobular, Databases, Factual, Female, Humans, Image-Guided Biopsy, Minimally Invasive Surgical Procedures, Phyllodes Tumor, Population Surveillance, Practice Guidelines as Topic
Abstract

PURPOSE: The second International Consensus Conference on B3 lesions was held in Zurich, Switzerland, in March 2018, organized by the International Breast Ultrasound School to re-evaluate the consensus recommendations. METHODS: This study (1) evaluated how management recommendations of the first Zurich Consensus Conference of 2016 on B3 lesions had influenced daily practice and (2) reviewed current literature towards recommendations to biopsy. RESULTS: In 2018, the consensus recommendations for management of B3 lesions remained almost unchanged: For flat epithelial atypia (FEA), classical lobular neoplasia (LN), papillary lesions (PL) and radial scars (RS) diagnosed on core-needle biopsy (CNB) or vacuum-assisted biopsy (VAB), excision by VAB in preference to open surgery, and for atypical ductal hyperplasia (ADH) and phyllodes tumors (PT) diagnosed at VAB or CNB, first-line open surgical excision (OE) with follow-up surveillance imaging for 5 years. Analyzing the Database of the Swiss Minimally Invasive Breast Biopsies (MIBB) with more than 30,000 procedures recorded, there was a significant increase in recommending more frequent surveillance of LN [65% in 2018 vs. 51% in 2016 (p = 0.004)], FEA (72% in 2018 vs. 62% in 2016 (p = 0.005)), and PL [(76% in 2018 vs. 70% in 2016 (p = 0.04)] diagnosed on VAB. A trend to more frequent surveillance was also noted also for RS [77% in 2018 vs. 67% in 2016 (p = 0.07)]. CONCLUSIONS: Minimally invasive management of B3 lesions (except ADH and PT) with VAB continues to be appropriate as an alternative to first-line OE in most cases, but with more frequent surveillance, especially for LN.

Published
2019

36. Overall survival in the OlympiA phase III trial of adjuvant olaparib in patients with germline pathogenic variants in BRCA1/2 and high-risk, early breast cancer

Author

Sevelda, Paul, Haslbauer, Ferdinand, Penzinger, Monika, Öhler, Leopold, Tinchon, Christoph, Greil, Richard, Heibl, Sonja, Bartsch, Rupert, Wette, Viktor, Singer, Christian F., Pasterk, Claudia, Helfgott, Ruth, Pristauz-Telsnigg, Gunda, Stöger, Herbert, Weltermann, Angsar, Egle, Daniel, Thiel, Irene, Fuchs, David, Rumpold, Holger, Strasser-Weippl, Kathrin, Rautenberg, Beate, Müller, Volkmar, Schmidt, Marcus, Paepke, Stefan, Aydogdu, Mustafa, Thomssen, Christoph, Rom, Joachim, Mau, Christine, Fasching, Peter, Göhring, Uwe-Jochen, Kühn, Thorsten, Noeding, Stefanie, Kümmel, Sherko, Hackmann, John, Stickeler, Elmar, Joshi, Abhishek, Dewar, Joanna, Friedlander, Michael, Phillips, Kelly-Anne, Antill, Yoland, Woodward, Natasha, Abdi, Ehtesham, Tiley, Susan, George, Mathew, Boadle, David, Goodwin, Annabel, van der Westhuizen, Andre, Kannourakis, George, Murray, Nicholas, McCarthy, Nicole, Kroep, Judith, de Boer, Maaike, Heijns, Joan, Jager, Agnes, Erdkamp, Franciscus, Bakker, Sandra, Sonke, Gabe S., Sami, Amer, Mackey, John, Prady, Catherine, Eisen, Andrea, Desbiens, Christine, Patocskai, Erica, Ferrario, Cristiano, Gelmon, Karen, Bordeleau, Louise, Chalchal, Haji, Niraula, Saroj, ido wolf, Senkus, Elżbieta, Duhoux, François, Randal d’Hondt, Luce, Sylvie, Roodenbeke, Daphné t’Kint de, Papadimitriou, Konstantinos, Borms, Marleen, Quaghebeur, Claire, Jacot, William, Brain, Etienne, Venat-Bouvet, Laurence, Lortholary, Alain, Nowecki, Zbigniew, Cardoso, Fátima, Hayward, Richard, Bella, Santiago, Lazzaro, Mauricio Fernández, Pilnik, Norma, Fein, Luis E., Blajman, Cesar, Lerzo, Guillermo, Varela, Mirta, Zarba, Juan Jose, Kaen, Diego, Constanzo, Maria Victoria, Tio, Joke, Siggelkow, Wulf, Jackisch, Christian, Grischke, Eva Maria, Zahm, Dirk, Tato-Varela, Sara, Schmatloch, Sabine, Klare, Peter, Stefek, Andrea, Rhiem, Kerstin, Hoffmann, Oliver, Deryal, Mustafa, Gröll, Isolde, Ledwon, Peter, Uleer, Christoph, Krabisch, Petra, Potenberg, Jochem, Darsow, Maren, Park-Simon, Tjoung-Won, Höffkes, Heinz-Gert, Emde, Till-Oliver, Graffunder, Gerd, Tomé, Oliver, Forstmeyer, Dirk, Terhaag, Jürgen, Salat, Christoph, Kast, Karin, Weniger, Steffi, Schreiber, Carsten, Heinrich, Bernhard, Dieterich, Max, Wüllner, Michaela Penelope, Conejero, Raquel Andrés, García Sáenz, José Ángel, Martinez, Lourdes Calvo, Lanza, Angels Arcusa, Murillo, Serafín Morales, Carrasco, Fernando Henao, Tormo, Salvador Blanch, López, Isabel Álvarez, Delgado Mingorance, Juan Ignacio, Gomez, Elena Álvarez, Santisteban, Marta, Jurado, Josefina Cruz, Quiroga, Vanesa, Borrego, Manuel Ruiz, Martínez de Dueñas, Eduardo, Alés Martínez, Jose Enrique, De la Haba, Juan, Jañez, Noelia Martínez, Lescure, Álvaro Rodríguez, Torres, Antonio Antón, Crusades, Gema Llort, González-Santiago, Santiago, Aragones, Antonia Marquez, Ortega, Ana Laura, Molins, Agusti Barnadas, Chacón López-Muñiz, José Ignacio, Jiménez, Miguel Martín, Bertrán, Ana Santaballa, Rodríguez, César, Cortijo, Lucía González, Cretella, Elisabetta, Cortesi, Laura, Ruggeri, Enzo Maria, Verusio, Claudio, Gori, Stefania, Bonetti, Andrea, Mosconi, Anna Maria, Johannsson, Oskar, Jerusalem, Guy, Neven, Patrick, Nagy, Tünde, Pinotti, Graziella, Colleoni, Marco A., Bernardo, Antonio, Gianni, Lorenzo, Bucci, Eraldo, Biganzoli, Laura, Dedes, Konstantin, Novak, Urban, Zaman, Khalil, Braybrooke, Jeremy, Winter, Matthew, Rea, Daniel, Kelleher, Muireann, Barrett, Sophie, Chan, Stephen, Hickish, Tamas, Hurwitz, Jane, Conibear, John, Jegannathen, Apurna, Parton, Marina, Tutt, Andrew, Allerton, Rozenn, Borley, Annabel, Armstrong, Anne, Copson, Ellen, Levitt, Nicola, Abraham, Jean, Perren, Timothy, Roylance, Rebecca, Ishida, Kazushige, Toyama, Tatsuya, Masuda, Norikazu, Watanabe, Junichiro, Tokunaga, Eriko, Kinoshita, Takayuki, Rai, Yoshiaki, Takada, Masahiro, Yanagita, Yasuhiro, Nakamura, Rikiya, Nakayama, Takahiro, Naoi, Yasuto, Iwata, Hiroji, Nakamura, Seigo, Takahashi, Masato, Aogi, Kenjiro, Tsugawa, Koichiro, Mukai, Hirofumi, Takano, Toshimi, Osaki, Akihiko, Sato, Nobuaki, Yamauchi, Hideko, Tokuda, Yutaka, Ito, Mitsuya, Sugimoto, Takeki, Bahadur, Shakeela W., Ganz, Patricia A., Lu, Min J., Mita, Monica M., Waisman, James, Polikoff, Jonathan A., Telli, Melinda L., Seaward, Samantha A., Suga, J. Marie, Durna, Lara N., Carney, Jennifer Fu, Menter, Alex, Puthillath, Ajithkumar, Rohatgi, Nitin, Feusner, James H., Bobolis, Kristie A., Eisenberg, Peter D., Wong, Derrick, Borges, Virginia F., Urquhart, Alexander T., Hofstatter, Erin W., McCarron, Edward C., Isaacs, Claudine, Herbolsheimer, Pia, Varadarajan, Ramya, Raben, Adam, Deveras, Ruby Anne E., Valdes-Albini, Frances, Mahtani, Reshma L., Meisel, Jane L., Sumrall, Bradley T., Jones, Cheryl F., Ofori, Samuel N., Sumida, Kenneth N.M., Karwal, Mark, Wilbur, Deborah W., Singh, (Joe), Spector, David M., Schallenkamp, John, Merkel, Douglas E., Lo, Shelly S., Khosla, Pam G., Cristofanilli, Massimo, Flaum, Lisa, Hoskins, Kent F., Cobleigh, Melody A., Lambiase, Elyse A., Hahn, Olwen M., Oliff, Ira A., Faller, Bryan A., Wade, James L., Burhani, Nafisa D., Gil, Amaryllis, Einhorn, Harvey E., Storniolo, Anna M.V., Chang, Brian K., Kalra, Maitri, Robin, Erwin L., Ansari, Bilal, Sharma, Priyanka, Dakhil, Shaker R., Deming, Richard L., Cole, John T., Hanson, David S., Ochoa, Augusto C., Garber, Judy E., Zimbler, Harvey, Armstrong, Deborah K., Tkaczuk, Katherine H.R., Riseberg, David A., O'Connor, Brian M., Openshaw, Thomas H., Zakalik, Dana, Vakhariya, Cynthia M., Schott, Anne F., Simon, Michael S., Doyle, Thomas J., Al Baghdadi, Tareq, VanderWoude, Amy, Flynn, Patrick J., Zera, Richard T., Friday, Bret E.B., Ruddy, Kathryn J., Smith, Ron, Ademuyiwa, Olabisi, Foluso, Ellis, Robert, Carlson, Jay W., Marchello, T, Benjamin, Levine, Edward A., Marcom, Paul K., Harkness, Cameron B., Tan, Antoinette R., Charles, William J., Kuzma, Charles S., Asaad, Shonda, Radford, James E., Steen, Preston D., Unnikrishnan, Madhu, Seeger, Grant R., Leu, Kirsten M.H., Copur, Mehmet S., Hauke, Ralph J., Soori, Gamini S., Arrick, Bradley A., Reeder, Jennifer G., Toppmeyer, Deborah L., Dayao, Zoneddy R., Adams, Sylvia, Andreopoulou, Eleni, Allison, Magnuson, Anampa Mesias, Jesus D., Sharma, Ruby, Ramaswamy, Bhuvaneswari, Gerds, Aaron T., Shenk, Robert R., Gross, Howard M., Trehan, Shruti, Razaq, Wajeeha, Mansoor, Abdul H., Hilton, Christie J., Brufsky, Adam M., Huynh, Chanh, Chowdhury, Nabila, Domchek, Susan M., Sigurdson, Elin R., Cescon, Terrence P., Rovito, Marc A., DeNittis, Albert S., Vogel, Victor G., Julian, Thomas B., Boyle, L.E., Baez-Diaz, Luis, Brescia, Frank J., Doster, John E., Siegel, Robert D., Wong, Lucas, Patel, Tejal, Nangia, Julie R., Jones, Catherine A., Cannon, George M., Bear, Harry D., Vachhani, Hetal, Wilkinson, Mary, Wood, Marie E., Yan, Fengting, Sui, Xingwei, van Haelst, Carol M., Specht, Jennifer M., Zhuo, Ying, Qamar, Rubina, Ryan, Matthew L., Stockham, Abigail, Virani, Shamsuddin, Gayle, Arlene A., Jubelirer, Steven J., Kurian, Sobha, Salkeni, Mohamad A., Loman, Niklas, Linderholm, Barbro, Silander, Gustav, Hallbeck, Anna-Lotta, von Wachenfeldt Väppling, Anna, Curtit, Elsa, Cardoso, Catarina, Braga, Sofia, Abreu, Miguel, Casa-Nova, Mafalda, Nave, Mónica, Ciruelos Gil, Eva María, Gelpi, Judith Balmaña, Ortega, Adela Fernández, Padró, Josep Gumà, Bermejo de las Heras, Begoña, Cao, María González, Bañuelos, Juan Cueva, Company, Jesús Alarcon, Villaró, Gemma Viñas, Estevez, Laura García, Huober, Jens, Busch, Steffi, Fehm, Tanja, Hahn, Antje, Grafe, Andrea, Noesselt, Thomas, Dewitz, Thomas, Wagner, Harald, Bechtner, Christina, Weigel, Michael, Kolberg, Hans-Christian, Decker, Thomas, Thomalla, Jörg, Hesse, Tobias, Harbeck, Nadia, Jens-Uwe Blohmer, Jan Schröder, Wolf Sütterlin, Marc, Altena, Renske, Chiu, Chang-Fang, Chen, Shin-Cheh, Hou, Ming-Feng, Chang, Yuan-Ching, Chen, Shang-Hung, Chen, Shou-Tung, Huang, Chiun-Sheng, Yeh, Dah-Cherng, Yu, Jyh-Cherng, Tseng, Ling-Ming, Chung, Wei-Pang, Mailliez, Audrey, Petit, Thierry, Delaloge, Suzette, Lévy, Christelle, Dalivoust, Philippe, Extra, Jean-Marc, Mouret-Reynier, Marie-Ange, Hardy-Bessard, Anne-Claire, Simon, Hélène, L'Haridon, Tiffenn, Mege, Alice, Giacchetti, Sylvie, Chakiba-Brugere, Camille, Gratet, Alain, Pottier, Virginie, Ferrero, Jean-Marc, Tennevet, Isabelle, Perrin, Christophe, Canon, Jean-Luc, Joris, Sofie, Shao, Zhimin, Xu, Binghe, Jiang, ZeFei, Sun, Qiang, Shen, Kunwei, Pang, Da, Zhang, Jin, Wang, Shui, Yang, Hongjian, Liao, Ning, Zheng, Hong, Fu, Peifen, Song, Chuangui, Wang, Yongsheng, Fan, Zhimin, Geng, Cuizhi, Tredan, Olivier, Landherr, László, Kaufman, Bella, Yerushalmi, Rinat, Uziely, Beatrice, Conte, Pierfranco, Zamagni, Claudio, Bianchini, Giampaolo, De Laurentiis, Michelino, Tondini, Carlo, Gebbia, Vittorio, Ciccarese, Mariangela, Sarosiek, Tomasz, Mackiewicz, Jacek, Słowińska, Anna, Kalinka, Ewa, Huzarski, Tomasz, Im, Seock-Ah, Jung, Kyung Hae, Sohn, Joo Hyuk, Kim, Jee Hyun, Lee, Keun Seok, Park, Yeon Hee, Lee, Kyoung Eun, Chae, Yee Soo, Cho, Eun Kyung, Geyer, C.E., Jr., Garber, J.E., Gelber, R.D., Yothers, G., Taboada, M., Ross, L., Rastogi, P., Cui, K., Arahmani, A., Aktan, G., Armstrong, A.C., Arnedos, M., Balmaña, J., Bergh, J., Bliss, J., Delaloge, S., Domchek, S.M., Eisen, A., Elsafy, F., Fein, L.E., Fielding, A., Ford, J.M., Friedman, S., Gelmon, K.A., Gianni, L., Gnant, M., Hollingsworth, S.J., Im, S.-A., Jager, A., Jóhannsson, Ó. Þ, Lakhani, S.R., Janni, W., Linderholm, B., Liu, T.-W., Loman, N., Korde, L., Loibl, S., Lucas, P.C., Marmé, F., Martinez de Dueñas, E., McConnell, R., Phillips, K.-A., Piccart, M., Rossi, G., Schmutzler, R., Senkus, E., Shao, Z., Sharma, P., Singer, C.F., Španić, T., Stickeler, E., Toi, M., Traina, T.A., Viale, G., Zoppoli, G., Park, Y.H., Yerushalmi, R., Yang, H., Pang, D., Jung, K.H., Mailliez, A., Fan, Z., Tennevet, I., Zhang, J., Nagy, T., Sonke, G.S., Sun, Q., Parton, M., Colleoni, M.A., Schmidt, M., Brufsky, A.M., Razaq, W., Kaufman, B., Cameron, D., Campbell, C., and Tutt, A.N.J.

Published
2022
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38. Efficacy of FOLFIRI plus cetuximab vs FOLFIRI plus bevacizumab in 1st-line treatment of older patients with RAS wild-type metastatic colorectal cancer: an analysis of the randomised trial FIRE-3

Author

Fischer, Laura E., Stintzing, Sebastian, von Weikersthal, Ludwig Fischer, Modest, Dominik P., Decker, Thomas, Kiani, Alexander, Kaiser, Florian, Al-Batran, Salah-Eddin, Heintges, Tobias, Lerchenmüller, Christian, Kahl, Christoph, Seipelt, Gernot, Kullmann, Frank, Stauch, Martina, Scheithauer, Werner, Giessen-Jung, Clemens, Uhlig, Jens, Peuser, Bettina, Denzlinger, Claudio, Stahler, Arndt, Weiss, Lena, Heinrich, Kathrin, Held, Swantje, Jung, Andreas, Kirchner, Thomas, and Heinemann, Volker

Published
2022
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39. First-line fluoropyrimidine plus bevacizumab followed by irinotecan-escalation versus initial fluoropyrimidine, irinotecan and bevacizumab in patients with metastatic colorectal cancer – Final survival and per-protocol analysis of the randomised XELAVIRI trial (AIO KRK 0110)

Author

Stahler, Arndt, Modest, Dominik P., Fischer von Weikersthal, Ludwig, Kaiser, Florian, Decker, Thomas, Held, Swantje, Graeven, Ullrich, Schwaner, Ingo, Denzlinger, Claudio, Schenk, Michael, Kurreck, Annika, Heinrich, Kathrin, Gießen-Jung, Clemens, Neumann, Jens, Kirchner, Thomas, Jung, Andreas, Stintzing, Sebastian, and Heinemann, Volker

Published
2022
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40. Cell-type-specific requirement for TYK2 in murine immune cells under steady state and challenged conditions.

Author

Karjalainen, Anzhelika, Witalisz-Siepracka, Agnieszka, Prchal-Murphy, Michaela, Martin, David, Sternberg, Felix, Krunic, Milica, Dolezal, Marlies, Fortelny, Nikolaus, Farlik, Matthias, Macho-Maschler, Sabine, Lassnig, Caroline, Meissl, Katrin, Amenitsch, Lena, Lederer, Therese, Pohl, Elena, Gotthardt, Dagmar, Bock, Christoph, Decker, Thomas, Strobl, Birgit, and Müller, Mathias

Abstract

Tyrosine kinase 2 (TYK2) deficiency and loss or inhibition of kinase activity in men and mice leads to similar immune compromised phenotypes, predominantly through impairment of interferon (IFN) and interleukin 12 family responses. Here we relate the transcriptome changes to phenotypical changes observed in TYK2-deficient (Tyk2−/−) and TYK2 kinase-inactive (Tyk2K923E) mice in naïve splenic immune cells and upon ex vivo IFN treatment or in vivo tumor transplant infiltration. The TYK2 activities under homeostatic and both challenged conditions are highly cell-type-specific with respect to quantity and quality of transcriptionally dependent genes. The major impact of loss of TYK2 protein or kinase activity in splenic homeostatic macrophages, NK and CD8+ T cells and tumor-derived cytolytic cells is on IFN responses. While reportedly TYK2 deficiency leads to partial impairment of IFN-I responses, we identified cell-type-specific IFN-I-repressed gene sets completely dependent on TYK2 kinase activity. Reported kinase-inactive functions of TYK2 relate to signaling crosstalk, metabolic functions and cell differentiation or maturation. None of these phenotypes relates to respective enriched gene sets in the TYK2 kinase-inactive cell types. Nonetheless, the scaffolding functions of TYK2 are capable to change transcriptional activities at single gene levels and chromatin accessibility at promoter-distal regions upon cytokine treatment most prominently in CD8+ T cells. The cell-type-specific transcriptomic and epigenetic effects of TYK2 shed new light on the biology of this JAK family member and are relevant for current and future treatment of autoimmune and inflammatory diseases with TYK2 inhibitors. [ABSTRACT FROM AUTHOR]

Published
2025
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41. Detection of particle contamination and lubrication outage in journal bearings in wind turbine gearboxes using surface acoustic wave measurements and machine learning.

Author

Decker, Thomas, Jacobs, Georg, Raddatz, Malte, Röder, Julian, Betscher, Jonas, and Arneth, Philipp

Abstract

Copyright of Forschung im Ingenieurwesen is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2025
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42. Investigation into the design of a novel conical plain bearing concept with enhanced serviceability.

Author

Euler, Jan, Jacobs, Georg, Zweiffel, Urs, Jakobs, Timm, Decker, Thomas, and Röder, Julian

Abstract

Copyright of Forschung im Ingenieurwesen is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2025
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43. Influence of hydrodynamic planetary journal bearings on the NVH-behavior of wind turbines.

Author

Sabry, Moataz, Jacobs, Georg, Decker, Thomas, Schünemann, Wilhelm, and Schelenz, Ralf

Abstract

Copyright of Forschung im Ingenieurwesen is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2025
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46. Best Management Practices for Trapping Furbearers in the United States

Author

WHITE, H. BRYANT, BATCHELLER, GORDON R., BOGGESS, EDWARD K., BROWN, CLIFFORD L., BUTFILOSKI, JOSEPH W., DECKER, THOMAS A., ERB, JOHN D., FALL, MICHAEL W., HAMILTON, DAVID A., HILLER, TIM L., HUBERT, GEORGE F., LOVALLO, MATTHEW J., OLSON, JOHN F., and ROBERTS, NATHAN M.

Published
2021

48. Infrared properties of micromachined vanadium oxide thin films

Author

Rees, Martin, Wang, Haifei, Decker, Thomas, and Smith, Robinson L.

Subjects
Condensed Matter - Materials Science
Abstract

This paper discusses questions of synthesizing and pressing vanadium oxides to create film-forming materials that can be used in producing optical coatings. Based on the film-forming materials thus created, technological processes have been developed for fabricating coatings from vanadium dioxide by two methods of producing thin films: vacuum evaporation and magnetron sputtering. Questions of using films made from vanadium oxide in optical instrumentation are considered., Comment: 13 pages, 4 figures, 3 tables

Published
2017

49. Consensus molecular subtypes in metastatic colorectal cancer treated with sequential versus combined fluoropyrimidine, bevacizumab and irinotecan (XELAVIRI trial)

Author

Stahler, Arndt, Heinemann, Volker, Schuster, Veronika, Heinrich, Kathrin, Kurreck, Annika, Gießen-Jung, Clemens, Fischer von Weikersthal, Ludwig, Kaiser, Florian, Decker, Thomas, Held, Swantje, Graeven, Ullrich, Schwaner, Ingo, Denzlinger, Claudio, Schenk, Michael, Neumann, Jens, Kirchner, Thomas, Jung, Andreas, Kumbrink, Jörg, Stintzing, Sebastian, and Modest, Dominik P.

Published
2021
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