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1. Cognitive reserve against Alzheimer’s pathology is linked to brain activity during memory formation

Author

Vockert, Niklas, Machts, Judith, Kleineidam, Luca, Nemali, Aditya, Incesoy, Enise I., Bernal, Jose, Schütze, Hartmut, Yakupov, Renat, Peters, Oliver, Gref, Daria, Schneider, Luisa Sophie, Preis, Lukas, Priller, Josef, Spruth, Eike Jakob, Altenstein, Slawek, Schneider, Anja, Fliessbach, Klaus, Wiltfang, Jens, Rostamzadeh, Ayda, Glanz, Wenzel, Teipel, Stefan, Kilimann, Ingo, Goerss, Doreen, Laske, Christoph, Munk, Matthias H., Spottke, Annika, Roy, Nina, Heneka, Michael T., Brosseron, Frederic, Wagner, Michael, Wolfsgruber, Steffen, Dobisch, Laura, Dechent, Peter, Hetzer, Stefan, Scheffler, Klaus, Zeidman, Peter, Stern, Yaakov, Schott, Björn H., Jessen, Frank, Düzel, Emrah, Maass, Anne, and Ziegler, Gabriel

Published
2024
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2. Perivascular space enlargement accelerates in ageing and Alzheimer’s disease pathology: evidence from a three-year longitudinal multicentre study

Author

Menze, Inga, Bernal, Jose, Kaya, Pinar, Aki, Çağla, Pfister, Malte, Geisendörfer, Jonas, Yakupov, Renat, Coello, Roberto Duarte, Valdés-Hernández, Maria d. C., Heneka, Michael T., Brosseron, Frederic, Schmid, Matthias C., Glanz, Wenzel, Incesoy, Enise I., Butryn, Michaela, Rostamzadeh, Ayda, Meiberth, Dix, Peters, Oliver, Preis, Lukas, Lammerding, Dominik, Gref, Daria, Priller, Josef, Spruth, Eike J., Altenstein, Slawek, Lohse, Andrea, Hetzer, Stefan, Schneider, Anja, Fliessbach, Klaus, Kimmich, Okka, Vogt, Ina R., Wiltfang, Jens, Bartels, Claudia, Schott, Björn H., Hansen, Niels, Dechent, Peter, Buerger, Katharina, Janowitz, Daniel, Perneczky, Robert, Rauchmann, Boris-Stephan, Teipel, Stefan, Kilimann, Ingo, Goerss, Doreen, Laske, Christoph, Munk, Matthias H., Sanzenbacher, Carolin, Hinderer, Petra, Scheffler, Klaus, Spottke, Annika, Roy-Kluth, Nina, Lüsebrink, Falk, Neumann, Katja, Wardlaw, Joanna, Jessen, Frank, Schreiber, Stefanie, Düzel, Emrah, and Ziegler, Gabriel

Published
2024
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3. Longitudinal evidence for a mutually reinforcing relationship between white matter hyperintensities and cortical thickness in cognitively unimpaired older adults

Author

Bernal, Jose, Menze, Inga, Yakupov, Renat, Peters, Oliver, Hellmann-Regen, Julian, Freiesleben, Silka Dawn, Priller, Josef, Spruth, Eike Jakob, Altenstein, Slawek, Schneider, Anja, Fliessbach, Klaus, Wiltfang, Jens, Schott, Björn H., Jessen, Frank, Rostamzadeh, Ayda, Glanz, Wenzel, Incesoy, Enise I., Buerger, Katharina, Janowitz, Daniel, Ewers, Michael, Perneczky, Robert, Rauchmann, Boris-Stephan, Teipel, Stefan, Kilimann, Ingo, Laske, Christoph, Sodenkamp, Sebastian, Spottke, Annika, Esser, Anna, Lüsebrink, Falk, Dechent, Peter, Hetzer, Stefan, Scheffler, Klaus, Schreiber, Stefanie, Düzel, Emrah, and Ziegler, Gabriel

Published
2024
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6. Different inflammatory signatures based on CSF biomarkers relate to preserved or diminished brain structure and cognition

Author

Hayek, Dayana, Ziegler, Gabriel, Kleineidam, Luca, Brosseron, Frederic, Nemali, Aditya, Vockert, Niklas, Ravichandran, Kishore A., Betts, Matthew J., Peters, Oliver, Schneider, Luisa-Sophie, Wang, Xiao, Priller, Josef, Altenstein, Slawek, Schneider, Anja, Fliessbach, Klaus, Wiltfang, Jens, Bartels, Claudia, Rostamzadeh, Ayda, Glanz, Wenzel, Buerger, Katharina, Janowitz, Daniel, Perneczky, Robert, Rauchmann, Boris-Stephan, Teipel, Stefan, Kilimann, Ingo, Laske, Christoph, Mengel, David, Synofzik, Matthis, Munk, Matthias H., Spottke, Annika, Roy, Nina, Roeske, Sandra, Kuhn, Elizabeth, Ramirez, Alfredo, Dobisch, Laura, Schmid, Matthias, Berger, Moritz, Wolfsgruber, Steffen, Yakupov, Renat, Hetzer, Stefan, Dechent, Peter, Ewers, Michael, Scheffler, Klaus, Schott, Björn H., Schreiber, Stefanie, Orellana, Adelina, de Rojas, Itziar, Marquié, Marta, Boada, Mercè, Sotolongo, Oscar, González, Pablo García, Puerta, Raquel, Düzel, Emrah, Jessen, Frank, Wagner, Michael, Ruiz, Augustín, Heneka, Michael T., and Maass, Anne

Published
2024
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8. Serum IL-6, sAXL, and YKL-40 as systemic correlates of reduced brain structure and function in Alzheimer’s disease: results from the DELCODE study

Author

Brosseron, Frederic, Maass, Anne, Kleineidam, Luca, Ravichandran, Kishore Aravind, Kolbe, Carl-Christian, Wolfsgruber, Steffen, Santarelli, Francesco, Häsler, Lisa M., McManus, Róisín, Ising, Christina, Röske, Sandra, Peters, Oliver, Cosma, Nicoleta-Carmen, Schneider, Luisa-Sophie, Wang, Xiao, Priller, Josef, Spruth, Eike J., Altenstein, Slawek, Schneider, Anja, Fliessbach, Klaus, Wiltfang, Jens, Schott, Björn H., Buerger, Katharina, Janowitz, Daniel, Dichgans, Martin, Perneczky, Robert, Rauchmann, Boris-Stephan, Teipel, Stefan, Kilimann, Ingo, Görß, Doreen, Laske, Christoph, Munk, Matthias H., Düzel, Emrah, Yakupow, Renat, Dobisch, Laura, Metzger, Coraline D., Glanz, Wenzel, Ewers, Michael, Dechent, Peter, Haynes, John Dylan, Scheffler, Klaus, Roy, Nina, Rostamzadeh, Ayda, Spottke, Annika, Ramirez, Alfredo, Mengel, David, Synofzik, Matthis, Jucker, Mathias, Latz, Eicke, Jessen, Frank, Wagner, Michael, and Heneka, Michael T.

Published
2023
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9. Arterial hypertension and β-amyloid accumulation have spatially overlapping effects on posterior white matter hyperintensity volume: a cross-sectional study

Author

Bernal, Jose, Schreiber, Stefanie, Menze, Inga, Ostendorf, Anna, Pfister, Malte, Geisendörfer, Jonas, Nemali, Aditya, Maass, Anne, Yakupov, Renat, Peters, Oliver, Preis, Lukas, Schneider, Luisa, Herrera, Ana Lucia, Priller, Josef, Spruth, Eike Jakob, Altenstein, Slawek, Schneider, Anja, Fliessbach, Klaus, Wiltfang, Jens, Schott, Björn H., Rostamzadeh, Ayda, Glanz, Wenzel, Buerger, Katharina, Janowitz, Daniel, Ewers, Michael, Perneczky, Robert, Rauchmann, Boris-Stephan, Teipel, Stefan, Kilimann, Ingo, Laske, Christoph, Munk, Matthias H., Spottke, Annika, Roy, Nina, Dobisch, Laura, Dechent, Peter, Scheffler, Klaus, Hetzer, Stefan, Wolfsgruber, Steffen, Kleineidam, Luca, Schmid, Matthias, Berger, Moritz, Jessen, Frank, Wirth, Miranka, Düzel, Emrah, and Ziegler, Gabriel

Published
2023
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10. Exploring the ATN classification system using brain morphology

Author

Heinzinger, Nils, Maass, Anne, Berron, David, Yakupov, Renat, Peters, Oliver, Fiebach, Jochen, Villringer, Kersten, Preis, Lukas, Priller, Josef, Spruth, Eike Jacob, Altenstein, Slawek, Schneider, Anja, Fliessbach, Klaus, Wiltfang, Jens, Bartels, Claudia, Jessen, Frank, Maier, Franziska, Glanz, Wenzel, Buerger, Katharina, Janowitz, Daniel, Perneczky, Robert, Rauchmann, Boris-Stephan, Teipel, Stefan, Killimann, Ingo, Göerß, Doreen, Laske, Christoph, Munk, Matthias H., Spottke, Annika, Roy, Nina, Heneka, Michael T., Brosseron, Frederic, Dobisch, Laura, Ewers, Michael, Dechent, Peter, Haynes, John Dylan, Scheffler, Klaus, Wolfsgruber, Steffen, Kleineidam, Luca, Schmid, Matthias, Berger, Moritz, Düzel, Emrah, and Ziegler, Gabriel

Published
2023
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11. Brain reserve contributes to distinguishing preclinical Alzheimer’s stages 1 and 2

Author

Yildirim, Zerrin, Delen, Firuze, Berron, David, Baumeister, Hannah, Ziegler, Gabriel, Schütze, Hartmut, Glanz, Wenzel, Dobisch, Laura, Peters, Oliver, Freiesleben, Silka Dawn, Schneider, Luisa-Sophie, Priller, Josef, Spruth, Eike Jakob, Schneider, Anja, Fliessbach, Klaus, Wiltfang, Jens, Schott, Björn-Hendrik, Meiberth, Dix, Buerger, Katharina, Janowitz, Daniel, Perneczky, Robert, Rauchmann, Boris-Stephan, Teipel, Stefan, Kilimann, Ingo, Laske, Christoph, Munk, Matthias H., Spottke, Annika, Roy, Nina, Heneka, Michael, Brosseron, Frederic, Wagner, Michael, Roeske, Sandra, Ramirez, Alfredo, Ewers, Michael, Dechent, Peter, Hetzer, Stefan, Scheffler, Klaus, Kleineidam, Luca, Wolfsgruber, Steffen, Yakupov, Renat, Schmid, Matthias, Berger, Moritz, Gurvit, Hakan, Jessen, Frank, and Duzel, Emrah

Published
2023
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12. Fornix fractional anisotropy mediates the association between Mediterranean diet adherence and memory four years later in older adults without dementia

Author

Ruiz-Rizzo, Adriana L., Finke, Kathrin, Damoiseaux, Jessica S., Bartels, Claudia, Buerger, Katharina, Cosma, Nicoleta Carmen, Dechent, Peter, Dobisch, Laura, Ewers, Michael, Fliessbach, Klaus, Frommann, Ingo, Glanz, Wenzel, Goerss, Doreen, Hetzer, Stefan, Incesoy, Enise I., Janowitz, Daniel, Kilimann, Ingo, Laske, Christoph, van Lent, Debora Melo, Munk, Matthias H.J., Peters, Oliver, Priller, Josef, Ramirez, Alfredo, Rostamzadeh, Ayda, Roy, Nina, Scheffler, Klaus, Schneider, Anja, Spottke, Annika, Spruth, Eike Jakob, Teipel, Stefan, Wagner, Michael, Wiltfang, Jens, Yakupov, Renat, Jessen, Frank, Duezel, Emrah, Perneczky, Robert, and Rauchmann, Boris-Stephan

Published
2024
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14. Improving 3D convolutional neural network comprehensibility via interactive visualization of relevance maps: Evaluation in Alzheimer's disease

Author

Dyrba, Martin, Hanzig, Moritz, Altenstein, Slawek, Bader, Sebastian, Ballarini, Tommaso, Brosseron, Frederic, Buerger, Katharina, Cantré, Daniel, Dechent, Peter, Dobisch, Laura, Düzel, Emrah, Ewers, Michael, Fliessbach, Klaus, Glanz, Wenzel, Haynes, John-Dylan, Heneka, Michael T., Janowitz, Daniel, Keles, Deniz B., Kilimann, Ingo, Laske, Christoph, Maier, Franziska, Metzger, Coraline D., Munk, Matthias H., Perneczky, Robert, Peters, Oliver, Preis, Lukas, Priller, Josef, Rauchmann, Boris, Roy, Nina, Scheffler, Klaus, Schneider, Anja, Schott, Björn H., Spottke, Annika, Spruth, Eike J., Weber, Marc-André, Ertl-Wagner, Birgit, Wagner, Michael, Wiltfang, Jens, Jessen, Frank, and Teipel, Stefan J.

Subjects
Electrical Engineering and Systems Science - Image and Video Processing, Computer Science - Computer Vision and Pattern Recognition
Abstract

Background: Although convolutional neural networks (CNN) achieve high diagnostic accuracy for detecting Alzheimer's disease (AD) dementia based on magnetic resonance imaging (MRI) scans, they are not yet applied in clinical routine. One important reason for this is a lack of model comprehensibility. Recently developed visualization methods for deriving CNN relevance maps may help to fill this gap. We investigated whether models with higher accuracy also rely more on discriminative brain regions predefined by prior knowledge. Methods: We trained a CNN for the detection of AD in N=663 T1-weighted MRI scans of patients with dementia and amnestic mild cognitive impairment (MCI) and verified the accuracy of the models via cross-validation and in three independent samples including N=1655 cases. We evaluated the association of relevance scores and hippocampus volume to validate the clinical utility of this approach. To improve model comprehensibility, we implemented an interactive visualization of 3D CNN relevance maps. Results: Across three independent datasets, group separation showed high accuracy for AD dementia vs. controls (AUC$\geq$0.92) and moderate accuracy for MCI vs. controls (AUC$\approx$0.75). Relevance maps indicated that hippocampal atrophy was considered as the most informative factor for AD detection, with additional contributions from atrophy in other cortical and subcortical regions. Relevance scores within the hippocampus were highly correlated with hippocampal volumes (Pearson's r$\approx$-0.86, p<0.001). Conclusion: The relevance maps highlighted atrophy in regions that we had hypothesized a priori. This strengthens the comprehensibility of the CNN models, which were trained in a purely data-driven manner based on the scans and diagnosis labels., Comment: 24 pages, 9 figures/tables, supplementary material, source code available on GitHub

Published
2020
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16. Linking early-life bilingualism and cognitive advantage in older adulthood

Author

Ballarini, Tommaso, Kuhn, Elizabeth, Röske, Sandra, Altenstein, Slawek, Bartels, Claudia, Buchholz, Friederike, Buerger, Katharina, Dechent, Peter, Dobisch, Laura, Ewers, Michael, Fliessbach, Klaus, Freiesleben, Silka Dawn, Frommann, Ingo, Gabelin, Tatjana, Glanz, Wenzel, Görß, Doreen, Haynes, John Dylan, Incesoy, Enise I., Janowitz, Daniel, Kilimann, Ingo, Kleineidam, Luca, Kobeleva, Xenia, Laske, Christoph, Lohse, Andrea, Maier, Franziska, Munk, Matthias H., Perneczky, Robert, Peters, Oliver, Priller, Josef, Rauchmann, Boris-Stephan, Roy, Nina, Scheffler, Klaus, Schneider, Anja, Schott, Björn H., Spottke, Annika, Spruth, Eike Jakob, Teipel, Stefan, Wiltfang, Jens, Wolfsgruber, Steffen, Düzel, Emrah, Jessen, Frank, and Wagner, Michael

Published
2023
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17. Influence of Bridge Deterioration on Its Natural Frequencies and Serviceability

Author

Torres, Matias, Cifuentes, Leonardo, Pradena, Mauricio, Dechent, Peter, di Prisco, Marco, Series Editor, Chen, Sheng-Hong, Series Editor, Vayas, Ioannis, Series Editor, Kumar Shukla, Sanjay, Series Editor, Sharma, Anuj, Series Editor, Kumar, Nagesh, Series Editor, Wang, Chien Ming, Series Editor, Pellegrino, Carlo, editor, Faleschini, Flora, editor, Zanini, Mariano Angelo, editor, Matos, José C., editor, Casas, Joan R., editor, and Strauss, Alfred, editor

Published
2022
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18. Lifelong experiences as a proxy of cognitive reserve moderate the association between connectivity and cognition in Alzheimer's disease

Author

Ersoezlue, Ersin, Rauchmann, Boris-Stephan, Schneider-Axmann, Thomas, Wagner, Michael, Ballarini, Tommaso, Tato, Maia, Utecht, Julia, Kurz, Carolin, Papazov, Boris, Guersel, Selim, Burow, Lena, Koller, Gabriele, Stöcklein, Sophia, Keeser, Daniel, Bartels, Claudia, Brosseron, Frederic, Buerger, Katharina, Cetindag, Arda C., Dechent, Peter, Dobisch, Laura, Ewers, Michael, Fliessbach, Klaus, Frommann, Ingo, Haynes, John D., Heneka, Michael T., Janowitz, Daniel, Kilimann, Ingo, Kleinedam, Luca, Laske, Christoph, Maier, Franziska, Metzger, Coraline D., Munk, Matthias H., Peters, Oliver, Preis, Lukas, Priller, Josef, Ramirez, Alfredo, Roeske, Sandra, Roy, Nina, Scheffler, Klaus, Schneider, Anja, Spottke, Annika, Spruth, Eike J., Teipel, Stefan, Wiltfang, Jens, Wolfsgruber, Steffen, Yakupov, Renat, Duezel, Emrah, Jessen, Frank, and Perneczky, Robert

Published
2023
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20. Single-value brain activity scores reflect both severity and risk across the Alzheimer's continuum.

Author

Soch, Joram, Richter, Anni, Kizilirmak, Jasmin M, Schütze, Hartmut, Ziegler, Gabriel, Altenstein, Slawek, Brosseron, Frederic, Dechent, Peter, Fliessbach, Klaus, Freiesleben, Silka Dawn, Glanz, Wenzel, Gref, Daria, Heneka, Michael T, Hetzer, Stefan, Incesoy, Enise I, Kilimann, Ingo, Kimmich, Okka, Kleineidam, Luca, Kuhn, Elizabeth, and Laske, Christoph

Subjects
FUNCTIONAL magnetic resonance imaging, ALZHEIMER'S disease, DISEASE risk factors, PROGNOSIS, YOUNG adults
Abstract

Single-value scores reflecting the deviation from (FADE score) or similarity with (SAME score) prototypical novelty-related and memory-related functional MRI activation patterns in young adults have been proposed as imaging biomarkers of healthy neurocognitive ageing. Here, we tested the utility of these scores as potential diagnostic and prognostic markers in Alzheimer's disease (AD) and risk states like mild cognitive impairment (MCI) or subjective cognitive decline (SCD). To this end, we analysed subsequent memory functional MRI data from individuals with SCD, MCI and AD dementia as well as healthy controls and first-degree relatives of AD dementia patients (AD-rel) who participated in the multi-centre DELCODE study (n = 468). Based on the individual participants' whole-brain functional MRI novelty and subsequent memory responses, we calculated the FADE and SAME scores and assessed their association with AD risk stage, neuropsychological test scores, CSF amyloid positivity and APOE genotype. Memory-based FADE and SAME scores showed a considerably larger deviation from a reference sample of young adults in the MCI and AD dementia groups compared to healthy controls, SCD and AD-rel. In addition, novelty-based scores significantly differed between the MCI and AD dementia groups. Across the entire sample, single-value scores correlated with neuropsychological test performance. The novelty-based SAME score further differed between Aβ-positive and Aβ-negative individuals in SCD and AD-rel, and between ApoE ɛ4 carriers and non-carriers in AD-rel. Hence, FADE and SAME scores are associated with both cognitive performance and individual risk factors for AD. Their potential utility as diagnostic and prognostic biomarkers warrants further exploration, particularly in individuals with SCD and healthy relatives of AD dementia patients. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Performance evaluation of automated white matter hyperintensity segmentation algorithms in a multicenter cohort on cognitive impairment and dementia

Author

Malo Gaubert, Andrea Dell’Orco, Catharina Lange, Antoine Garnier-Crussard, Isabella Zimmermann, Martin Dyrba, Marco Duering, Gabriel Ziegler, Oliver Peters, Lukas Preis, Josef Priller, Eike Jakob Spruth, Anja Schneider, Klaus Fliessbach, Jens Wiltfang, Björn H. Schott, Franziska Maier, Wenzel Glanz, Katharina Buerger, Daniel Janowitz, Robert Perneczky, Boris-Stephan Rauchmann, Stefan Teipel, Ingo Kilimann, Christoph Laske, Matthias H. Munk, Annika Spottke, Nina Roy, Laura Dobisch, Michael Ewers, Peter Dechent, John Dylan Haynes, Klaus Scheffler, Emrah Düzel, Frank Jessen, Miranka Wirth, for the DELCODE study group, Amthauer Holger, Cetindag Arda Can, Cosma Nicoleta Carmen, Diesing Dominik, Ehrlich Marie, Fenski Frederike, Freiesleben Silka Dawn, Fuentes Manuel, Hauser Dietmar, Hujer Nicole, Incesoy Enise Irem, Kainz Christian, Lange Catharina, Lindner Katja, Megges Herlind, Peters Oliver, Preis Lukas, Altenstein Slawek, Lohse Andrea, Franke Christiana, Priller Josef, Spruth Eike, Villar Munoz Irene, Barkhoff Miriam, Boecker Henning, Brosseron Frederic, Daamen Marcel, Engels Tanja, Faber Jennifer, Fließbach Klaus, Frommann Ingo, Grobe-Einsler Marcus, Hennes Guido, Herrmann Gabi, Jost Lorraine, Kalbhen Pascal, Kimmich Okka, Kobeleva Xenia, Kofler Barbara, McCormick Cornelia, Miebach Lisa, Miklitz Carolin, Müller Anna, Oender Demet, Polcher Alexandra, Purrer Veronika, Röske Sandra, Schneider Christine, Schneider Anja, Spottke Annika, Vogt Ina, Wagner Michael, wolfsgruber Steffen, Yilmaz Sagik, Bartels Claudia, Dechent Peter, Hansen Niels, Hassoun Lina, Hirschel Sina, Nuhn Sabine, Pfahlert Ilona, Rausch Lena, Schott Björn, Timäus Charles, Werner Christine, Wiltfang Jens, Zabel Lioba, Zech Heike, Bader Abdelmajid, Baldermann Juan Carlos, Dölle Britta, Drzezga Alexander, Escher Claus, Ghiasi Nasim Roshan, Hardenacke Katja, Jessen Frank, Lützerath Hannah, Maier Franziska, Marquardt Benjamin, Martikke Anja, Meiberth Dix, Petzler Snjezana, Rostamzadeh Ayda, Sannemann Lena, Schild Ann-Katrin, Sorgalla Susanne, Stockter Simone, Thelen Manuela, Tscheuschler Maike, Uhle Franziska, Zeyen Philip, Bittner Daniel, Cardenas-Blanco Arturo, Dobisch Laura, Düzel Emrah, Grieger-Klose Doreen, Hartmann Deike, Metzger Coraline, Nestor Peter, Ruß Christin, Schulze Franziska, Speck Oliver, Yakupov Renat, Ziegler Gabriel, Brauneis Christine, Bürger Katharina, Catak Cihan, Coloma Andrews Lisa, Dichgans Martin, Dörr Angelika, Ertl-Wagner Birgit, Frimmer Daniela, Huber Brigitte, Janowitz Daniel, Kreuzer Max, Markov Eva, Müller Claudia, Rominger Axel, Schmid (ehemals Spreider) Jennifer, Seegerer Anna, Stephan Julia, Zollver Adelgunde, Burow Lena, de Jonge Sylvia, Falkai Peter, Garcia Angarita Natalie, Görlitz Thomas, Gürsel Selim Üstün, Horvath Ildiko, Kurz Carolin, Meisenzahl-Lechner Eva, Perneczky Robert, Utecht Julia, Dyrba Martin, Janecek-Meyer Heike, Kilimann Ingo, Lappe Chris, Lau Esther, Pfaff Henrike, Raum Heike, Sabik Petr, Schmidt Monika, Schulz Heike, Schwarzenboeck Sarah, Teipel Stefan, Weber Marc-Andre, Buchmann Martina, Heger Tanja, Hinderer Petra, Kuder-Buletta Elke, Laske Christoph, Munk Matthias, Mychajliw Christian, Soekadar Surjo, sulzer Patricia, and Trunk Theresia

Subjects
white matter hyperintensities segmentation, evaluation, FLAIR, deep learning, aging, Alzheimer’s disease, Psychiatry, RC435-571
Abstract

BackgroundWhite matter hyperintensities (WMH), a biomarker of small vessel disease, are often found in Alzheimer’s disease (AD) and their advanced detection and quantification can be beneficial for research and clinical applications. To investigate WMH in large-scale multicenter studies on cognitive impairment and AD, appropriate automated WMH segmentation algorithms are required. This study aimed to compare the performance of segmentation tools and provide information on their application in multicenter research.MethodsWe used a pseudo-randomly selected dataset (n = 50) from the DZNE-multicenter observational Longitudinal Cognitive Impairment and Dementia Study (DELCODE) that included 3D fluid-attenuated inversion recovery (FLAIR) images from participants across the cognitive continuum. Performances of top-rated algorithms for automated WMH segmentation [Brain Intensity Abnormality Classification Algorithm (BIANCA), lesion segmentation toolbox (LST), lesion growth algorithm (LGA), LST lesion prediction algorithm (LPA), pgs, and sysu_media] were compared to manual reference segmentation (RS).ResultsAcross tools, segmentation performance was moderate for global WMH volume and number of detected lesions. After retraining on a DELCODE subset, the deep learning algorithm sysu_media showed the highest performances with an average Dice’s coefficient of 0.702 (±0.109 SD) for volume and a mean F1-score of 0.642 (±0.109 SD) for the number of lesions. The intra-class correlation was excellent for all algorithms (>0.9) but BIANCA (0.835). Performance improved with high WMH burden and varied across brain regions.ConclusionTo conclude, the deep learning algorithm, when retrained, performed well in the multicenter context. Nevertheless, the performance was close to traditional methods. We provide methodological recommendations for future studies using automated WMH segmentation to quantify and assess WMH along the continuum of cognitive impairment and AD dementia.

Published
2023
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23. Subject-Specific Resting-State Functional Connectivity to Personalize rTMS Interventions In Major Depressive Disorder

Author

Wilkening, Jonas, primary, Jungeblut, Henrike M., additional, Adamovic, Ivana, additional, Belov, Vladimir, additional, Dechent, Peter, additional, Eicke, Lara, additional, Hansen, Niels, additional, Kozyrev, Vladislav, additional, Marten, Lara E., additional, Muschke, Yonca, additional, Riemer, Caspar, additional, Schnell, Knut, additional, Tura, Asude, additional, Wilke, Melanie, additional, Witteler, Fabian, additional, Wiltfang, Jens, additional, Wunderlich, Anna, additional, Zimmeck, Valerie, additional, Zobott, Anna, additional, Schmidt-Samoa, Carsten, additional, Erwin-Grabner, Tracy, additional, and Goya-Maldonado, Roberto, additional

Published
2024
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24. Machine Learning–Based Perivascular Space Volumetry in Alzheimer Disease

Author

Deike, Katerina, primary, Decker, Andreas, additional, Scheyhing, Paul, additional, Harten, Julia, additional, Zimmermann, Nadine, additional, Paech, Daniel, additional, Peters, Oliver, additional, Freiesleben, Silka D., additional, Schneider, Luisa-Sophie, additional, Preis, Lukas, additional, Priller, Josef, additional, Spruth, Eike, additional, Altenstein, Slawek, additional, Lohse, Andrea, additional, Fliessbach, Klaus, additional, Kimmich, Okka, additional, Wiltfang, Jens, additional, Bartels, Claudia, additional, Hansen, Niels, additional, Jessen, Frank, additional, Rostamzadeh, Ayda, additional, Düzel, Emrah, additional, Glanz, Wenzel, additional, Incesoy, Enise I., additional, Butryn, Michaela, additional, Buerger, Katharina, additional, Janowitz, Daniel, additional, Ewers, Michael, additional, Perneczky, Robert, additional, Rauchmann, Boris-Stephan, additional, Teipel, Stefan, additional, Kilimann, Ingo, additional, Goerss, Doreen, additional, Laske, Christoph, additional, Munk, Matthias H., additional, Spottke, Annika, additional, Roy, Nina, additional, Wagner, Michael, additional, Roeske, Sandra, additional, Heneka, Michael T., additional, Brosseron, Frederic, additional, Ramirez, Alfredo, additional, Dobisch, Laura, additional, Wolfsgruber, Steffen, additional, Kleineidam, Luca, additional, Yakupov, Renat, additional, Stark, Melina, additional, Schmid, Matthias C., additional, Berger, Moritz, additional, Hetzer, Stefan, additional, Dechent, Peter, additional, Scheffler, Klaus, additional, Petzold, Gabor C., additional, Schneider, Anja, additional, Effland, Alexander, additional, and Radbruch, Alexander, additional

Published
2024
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25. Quantitative T1 is Sensitive to Cortical Remyelination in People with Multiple Sclerosis: A Postmortem 3T-MRI Study (P11-6.009)

Author

Galbusera, Riccardo, primary, Weigel, Matthias, additional, Bahn, Erik, additional, Schaedelin, Sabine, additional, Cagol, Alessandro, additional, Lu, Po-Jui, additional, Barakovic, Muhamed, additional, Melie-Garcia, Lester, additional, Franz, Jonas, additional, Dechent, Peter, additional, Nair, Govind, additional, Kappos, Ludwig, additional, Brueck, Wolfgang, additional, Stadelmann-Nessler, Christine, additional, and Granziera, Cristina, additional

Published
2024
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29. Improving 3D convolutional neural network comprehensibility via interactive visualization of relevance maps: evaluation in Alzheimer’s disease

Author

Dyrba, Martin, Hanzig, Moritz, Altenstein, Slawek, Bader, Sebastian, Ballarini, Tommaso, Brosseron, Frederic, Buerger, Katharina, Cantré, Daniel, Dechent, Peter, Dobisch, Laura, Düzel, Emrah, Ewers, Michael, Fliessbach, Klaus, Glanz, Wenzel, Haynes, John-Dylan, Heneka, Michael T., Janowitz, Daniel, Keles, Deniz B., Kilimann, Ingo, Laske, Christoph, Maier, Franziska, Metzger, Coraline D., Munk, Matthias H., Perneczky, Robert, Peters, Oliver, Preis, Lukas, Priller, Josef, Rauchmann, Boris, Roy, Nina, Scheffler, Klaus, Schneider, Anja, Schott, Björn H., Spottke, Annika, Spruth, Eike J., Weber, Marc-André, Ertl-Wagner, Birgit, Wagner, Michael, Wiltfang, Jens, Jessen, Frank, and Teipel, Stefan J.

Published
2021
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32. Short communication: Lifetime musical activity and resting-state functional connectivity in cognitive networks.

Author

Liebscher, Maxie, Dell'Orco, Andrea, Doll-Lee, Johanna, Buerger, Katharina, Dechent, Peter, Ewers, Michael, Fliessbach, Klaus, Glanz, Wenzel, Hetzer, Stefan, Janowitz, Daniel, Kilimann, Ingo, Laske, Christoph, Lüsebrink, Falk, Munk, Matthias, Perneczky, Robert, Peters, Oliver, Preis, Lukas, Priller, Josef, Rauchmann, Boris, and Rostamzadeh, Ayda

Subjects
VOXEL-based morphometry, FUNCTIONAL connectivity, DEFAULT mode network, LARGE-scale brain networks, FRONTAL lobe, MUSICAL instruments, PREFRONTAL cortex, GRAY matter (Nerve tissue)
Abstract

Background: Participation in multimodal leisure activities, such as playing a musical instrument, may be protective against brain aging and dementia in older adults (OA). Potential neuroprotective correlates underlying musical activity remain unclear. Objective: This cross-sectional study investigated the association between lifetime musical activity and resting-state functional connectivity (RSFC) in three higher-order brain networks: the Default Mode, Fronto-Parietal, and Salience networks. Methods: We assessed 130 cognitively unimpaired participants (≥ 60 years) from the baseline cohort of the DZNE-Longitudinal Cognitive Impairment and Dementia Study (DELCODE) study. Lifetime musical activity was operationalized by the self-reported participation in musical instrument playing across early, middle, and late life stages using the Lifetime of Experiences Questionnaire (LEQ). Participants who reported musical activity during all life stages (n = 65) were compared to controls who were matched on demographic and reserve characteristics (including education, intelligence, socioeconomic status, self-reported physical activity, age, and sex) and never played a musical instrument (n = 65) in local (seed-to-voxel) and global (within-network and between-network) RSFC patterns using pre-specified network seeds. Results: Older participants with lifetime musical activity showed significantly higher local RSFC between the medial prefrontal cortex (Default Mode Network seed) and temporal as well as frontal regions, namely the right temporal pole and the right precentral gyrus extending into the superior frontal gyrus, compared to matched controls. There were no significant group differences in global RSFC within or between the three networks. Conclusion: We show that playing a musical instrument during life relates to higher RSFC of the medial prefrontal cortex with distant brain regions involved in higher-order cognitive and motor processes. Preserved or enhanced functional connectivity could potentially contribute to better brain health and resilience in OA with a history in musical activity. Trial registration: German Clinical Trials Register (DRKS00007966, 04/05/2015). [ABSTRACT FROM AUTHOR]

Published
2024
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33. Folate receptor α deficiency – Myelin‐sensitive MRI as a reliable biomarker to monitor the efficacy and long‐term outcome of a new therapeutic approach.

Author

Dreha‐Kulaczewski, Steffi, Sahoo, Prativa, Preusse, Matthias, Gkalimani, Irini, Dechent, Peter, Helms, Gunther, Hofer, Sabine, Steinfeld, Robert, and Gärtner, Jutta

Abstract

Cerebral folate transport deficiency, caused by a genetic defect in folate receptor α, is a devastating neurometabolic disorder that, if untreated, leads to epileptic encephalopathy, psychomotor decline and hypomyelination. Currently, there are limited data on effective dosage and duration of treatment, though early diagnosis and therapy with folinic acid appears critical. The aim of this long‐term study was to identify new therapeutic approaches and novel biomarkers for assessing efficacy, focusing on myelin‐sensitive MRI. Clinical, biochemical, structural and quantitative MRI parameters of seven patients with genetically confirmed folate receptor α deficiency were acquired over 13 years. Multimodal MRI approaches comprised MR‐spectroscopy (MRS), magnetization transfer (MTI) and diffusion tensor imaging (DTI) sequences. Patients started oral treatment immediately following diagnosis or in an interval of up to 2.5 years. Escalation to intravenous and intrathecal administration was performed in the absence of effects. Five patients improved, one with a presymptomatic start of therapy remained symptom‐free, and one with inconsistent treatment deteriorated. While CSF 5‐methyltetrahydrofolate and MRS parameters normalized immediately after therapy initiation, myelin‐sensitive MTI and DTI measures correlated with gradual clinical improvement and ongoing myelination under therapy. Early initiation of treatment at sufficient doses, considering early intrathecal applications, is critical for favorable outcome. The majority of patients showed clinical improvements that correlated best with MTI parameters, allowing individualized monitoring of myelination recovery. Presymptomatic therapy seems to ensure normal development and warrants newborn screening. Furthermore, the quantitative parameters of myelin‐sensitive MRI for therapy assessments can now be used for hypomyelination disorders in general. [ABSTRACT FROM AUTHOR]

Published
2024
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34. Machine learning‐based classification of Alzheimer's disease and its at‐risk states using personality traits, anxiety, and depression

Author

Waschkies, Konrad F., primary, Soch, Joram, additional, Darna, Margarita, additional, Richter, Anni, additional, Altenstein, Slawek, additional, Beyle, Aline, additional, Brosseron, Frederic, additional, Buchholz, Friederike, additional, Butryn, Michaela, additional, Dobisch, Laura, additional, Ewers, Michael, additional, Fliessbach, Klaus, additional, Gabelin, Tatjana, additional, Glanz, Wenzel, additional, Goerss, Doreen, additional, Gref, Daria, additional, Janowitz, Daniel, additional, Kilimann, Ingo, additional, Lohse, Andrea, additional, Munk, Matthias H., additional, Rauchmann, Boris‐Stephan, additional, Rostamzadeh, Ayda, additional, Roy, Nina, additional, Spruth, Eike Jakob, additional, Dechent, Peter, additional, Heneka, Michael T., additional, Hetzer, Stefan, additional, Ramirez, Alfredo, additional, Scheffler, Klaus, additional, Buerger, Katharina, additional, Laske, Christoph, additional, Perneczky, Robert, additional, Peters, Oliver, additional, Priller, Josef, additional, Schneider, Anja, additional, Spottke, Annika, additional, Teipel, Stefan, additional, Düzel, Emrah, additional, Jessen, Frank, additional, Wiltfang, Jens, additional, Schott, Björn H., additional, and Kizilirmak, Jasmin M., additional

Published
2023
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35. Perivascular space enlargement accelerates with hypertension, white matter hyperintensities, chronic inflammation, and Alzheimer's disease pathology: evidence from a three-year longitudinal multicentre study

Author

Menze, Inga, primary, Bernal, Jose, additional, Kaya, Pinar, additional, Aki, Çağla, additional, Pfister, Malte, additional, Geisendörfer, Jonas, additional, Yakupov, Renat, additional, Heneka, Michael T., additional, Brosseron, Frederic, additional, Schmid, Matthias C., additional, Glanz, Wenzel, additional, Incesoy, Enise I., additional, Butryn, Michaela, additional, Rostamzadeh, Ayda, additional, Meiberth, Dix, additional, Peters, Oliver, additional, Preis, Lukas, additional, Lammerding, Dominik, additional, Gref, Daria, additional, Priller, Josef, additional, Spruth, Eike J., additional, Altenstein, Slawek, additional, Lohse, Andrea, additional, Hetzer, Stefan, additional, Schneider, Anja, additional, Fliessbach, Klaus, additional, Kimmich, Okka, additional, Vogt, Ina R., additional, Wiltfang, Jens, additional, Bartels, Claudia, additional, Schott, Björn H., additional, Hansen, Niels, additional, Dechent, Peter, additional, Buerger, Katharina, additional, Janowitz, Daniel, additional, Perneczky, Robert, additional, Rauchmann, Boris-Stephan, additional, Teipel, Stefan, additional, Kilimann, Ingo, additional, Goerss, Doreen, additional, Laske, Christoph, additional, Munk, Matthias H., additional, Sanzenbacher, Carolin, additional, Hinderer, Petra, additional, Scheffler, Klaus, additional, Spottke, Annika, additional, Roy-Kluth, Nina, additional, Lüsebrink, Falk, additional, Neumann, Katja, additional, Jessen, Frank, additional, Schreiber, Stefanie, additional, Düzel, Emrah, additional, and Ziegler, Gabriel, additional

Published
2023
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40. Novelty-Related fMRI Responses of Precuneus and Medial Temporal Regions in Individuals at Risk for Alzheimer Disease

Author

Billette, Ornella V, Ziegler, Gabriel, Dahmen, Philip, Dechent, Peter, Dobisch, Laura, Fliessbach, Klaus, Freiesleben, Silka Dawn, Glanz, Wenzel, Göerß, Doreen, Haynes, John Dylan, Heneka, Michael T, Kilimann, Ingo, Aruci, Merita, Kimmich, Okka, Kleineidam, Luca, Laske, Christoph, Lohse, Andrea, Rostamzadeh, Ayda, Metzger, Coraline, Munk, Matthias H, Peters, Oliver, Preis, Lukas, Priller, Josef, Schütze, Hartmut, Scheffler, Klaus, Schneider, Anja, Spottke, Annika, Spruth, Eike Jakob, Ramirez, Alfredo, Röske, Sandra, Roy, Nina, Teipel, Stefan, Wagner, Michael, Wiltfang, Jens, Kizilirmak, Jasmin M, Wolfsgruber, Steffen, Yakupov, Renat, Zeidman, Peter, Jessen, Frank, Schott, Björn, Düzel, Emrah, Maass, Anne, Group, DELCODE Study, Richter, Anni, Altenstein, Slawek, Bartels, Claudia, Brosseron, Frederic, and Cardenas-Blanco, Arturo

Subjects
Alzheimer Disease/diagnosis, Amyloid beta-Peptides, Cognitive Dysfunction/diagnostic imaging, diagnosis [Alzheimer Disease], diagnostic imaging [Cognitive Dysfunction], Magnetic Resonance Imaging, Temporal Lobe/diagnostic imaging, Temporal Lobe, Magnetic Resonance Imaging/methods, diagnostic imaging [Parietal Lobe], Parietal Lobe/diagnostic imaging, methods [Magnetic Resonance Imaging], diagnostic imaging [Temporal Lobe], Alzheimer Disease, Parietal Lobe, Humans, Cognitive Dysfunction, ddc:610, Neurology (clinical), Biomarkers
Abstract

Background and ObjectivesWe assessed whether novelty-related fMRI activity in medial temporal lobe regions and the precuneus follows an inverted U-shaped pattern across the clinical spectrum of increased Alzheimer disease (AD) risk as previously suggested. Specifically, we tested for potentially increased activity in individuals with a higher AD risk due to subjective cognitive decline (SCD) or mild cognitive impairment (MCI). We further tested whether activity differences related to diagnostic groups were accounted for by CSF markers of AD or brain atrophy.MethodsWe studied 499 participants aged 60–88 years from the German Center for Neurodegenerative Diseases Longitudinal Cognitive Impairment and Dementia Study (DELCODE) who underwent task-fMRI. Participants included 163 cognitively normal (healthy control, HC) individuals, 222 SCD, 82 MCI, and 32 patients with clinical diagnosis of mild AD. CSF levels of β-amyloid 42/40 ratio and phosphorylated-tau181 were available from 232 participants. We used region-based analyses to assess novelty-related activity (novel > highly familiar scenes) in entorhinal cortex, hippocampus, and precuneus as well as whole-brain voxel-wise analyses. First, general linear models tested differences in fMRI activity between participant groups. Complementary regression models tested quadratic relationships between memory impairment and activity. Second, relationships of activity with AD CSF biomarkers and brain volume were analyzed. Analyses were controlled for age, sex, study site, and education.ResultsIn the precuneus, we observed an inverted U-shaped pattern of novelty-related activity across groups, with higher activity in SCD and MCI compared with HC, but not in patients with AD who showed relatively lower activity than MCI. This nonlinear pattern was confirmed by a quadratic relationship between memory impairment and precuneus activity. Precuneus activity was not related to AD biomarkers or brain volume. In contrast to the precuneus, hippocampal activity was reduced in AD dementia compared with all other groups and related to AD biomarkers.DiscussionNovelty-related activity in the precuneus follows a nonlinear pattern across the clinical spectrum of increased AD risk. Although the underlying mechanism remains unclear, increased precuneus activity might represent an early signature of memory impairment. Our results highlight the nonlinearity of activity alterations that should be considered in clinical trials using functional outcome measures or targeting hyperactivity.

Published
2022

41. A 6-items Questionnaire (6-QMD) captures a Mediterranean like dietary pattern and is associated with memory performance and hippocampal volume in elderly and persons at risk for Alzheimer’s disease

Author

Rauchmann, Boris-Stephan, primary, Gross, Patrizia, additional, Ersoezlue, Ersin, additional, Wagner, Michael, additional, Tommaso, Ballarini, additional, Kurz, Carolin, additional, Tatò, Maia, additional, Utecht, Julia, additional, Papazov, Boris, additional, Guersel, Selim, additional, Totzke, Marie, additional, Trappmann, Lena, additional, Burow, Lena, additional, Koller, Gabriele, additional, Stöcklein, Sophia, additional, Keeser, Daniel, additional, Altenstein, Slawek, additional, Bartels, Claudia, additional, Buerger, Katharina, additional, Dechent, Peter, additional, Dobisch, Laura, additional, Ewers, Michael, additional, Fliessbach, Klaus, additional, Freiesleben, Silka Dawn, additional, Glanz, Wenzel, additional, Goeerss, Doreen, additional, Gref, Daria, additional, Haynes, John Dylan, additional, Janowitz, Daniel, additional, Kilimann, Ingo, additional, Kimmich, Okka, additional, Kleineidam, Luca, additional, Laske, Christoph, additional, Lohse, Andrea, additional, Maier, Franziska, additional, Metzger, Coraline D., additional, Munk, Matthias H., additional, Peters, Oliver, additional, Preis, Lukas, additional, Priller, Josef, additional, Roeske, Sandra, additional, Roy, Nina, additional, Sanzenbacher, Carolin, additional, Scheffler, Klaus, additional, Schneider, Anja, additional, Schott, Björn Hendrik, additional, Spottke, Annika, additional, Spruth, Eike Jakob, additional, Teipel, Stefan, additional, van Lent, Debora Melo, additional, Wiltfang, Jens, additional, Wolfsgruber, Steffen, additional, Yakupov, Renat, additional, Düzel, Emrah, additional, Jessen, Frank, additional, and Perneczky, Robert, additional

Published
2023
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42. Altered limbic functional connectivity in individuals with subjective cognitive decline: Converging and diverging findings across Chinese and German cohorts

Author

Jiang, Xueyan, primary, Hu, Xiaochen, additional, Daamen, Marcel, additional, Wang, Xiaoqi, additional, Fan, Chunqiu, additional, Meiberth, Dix, additional, Spottke, Annika, additional, Roeske, Sandra, additional, Fliessbach, Klaus, additional, Spruth, Eike Jakob, additional, Altenstein, Slawek, additional, Lohse, Andrea, additional, Hansen, Niels, additional, Glanz, Wenzel, additional, Incesoy, Enise I., additional, Dobisch, Laura, additional, Janowitz, Daniel, additional, Rauchmann, Boris‐Stephan, additional, Ramirez, Alfredo, additional, Kilimann, Ingo, additional, Munk, Matthias H., additional, Wang, Xiao, additional, Schneider, Luisa‐Sophie, additional, Gabelin, Tatjana, additional, Roy, Nina, additional, Wolfsgruber, Steffen, additional, Kleineidam, Luca, additional, Hetzer, Stefan, additional, Dechent, Peter, additional, Ewers, Michael, additional, Scheffler, Klaus, additional, Amthauer, Holger, additional, Buchert, Ralph, additional, Essler, Markus, additional, Drzezga, Alexander, additional, Rominger, Axel, additional, Krause, Bernd J., additional, Reimold, Matthias, additional, Priller, Josef, additional, Schneider, Anja, additional, Wiltfang, Jens, additional, Buerger, Katharina, additional, Perneczky, Robert, additional, Teipel, Stefan, additional, Laske, Christoph, additional, Peters, Oliver, additional, Düzel, Emrah, additional, Wagner, Michael, additional, Jiang, Jiehui, additional, Jessen, Frank, additional, Boecker, Henning, additional, and Han, Ying, additional

Published
2023
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43. Impact of excessive abdominal obesity on brain microstructural abnormality in schizophrenia

Author

Yamada, Shinichi, primary, Takahashi, Shun, additional, Keeser, Daniel, additional, Keller-Varady, Katriona, additional, Schneider-Axmann, Thomas, additional, Raabe, Florian J., additional, Dechent, Peter, additional, Wobrock, Thomas, additional, Hasan, Alkomiet, additional, Schmitt, Andrea, additional, Falkai, Peter, additional, Kimoto, Sohei, additional, and Malchow, Berend, additional

Published
2023
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47. Altered limbic functional connectivity in individuals with subjective cognitive decline: Converging and diverging findings across Chinese and German cohorts

Author

Jiang, Xueyan, Hu, Xiaochen, Daamen, Marcel, Wang, Xiaoqi, Fan, Chunqiu, Meiberth, Dix, Spottke, Annika, Roeske, Sandra, Fliessbach, Klaus, Spruth, Eike Jakob, Altenstein, Slawek, Lohse, Andrea, Hansen, Niels, Glanz, Wenzel, Incesoy, Enise I, Dobisch, Laura, Janowitz, Daniel, Rauchmann, Boris-Stephan, Ramirez, Alfredo, Kilimann, Ingo, Munk, Matthias H, Wang, Xiao, Schneider, Luisa-Sophie, Gabelin, Tatjana, Roy, Nina, Wolfsgruber, Steffen, Kleineidam, Luca, Hetzer, Stefan, Dechent, Peter, Ewers, Michael, Scheffler, Klaus, Amthauer, Holger, Buchert, Ralph, Essler, Markus, Drzezga, Alexander, Rominger, Axel, Krause, Bernd J, Reimold, Matthias, Priller, Josef, Schneider, Anja, Wiltfang, Jens, Buerger, Katharina, Perneczky, Robert, Teipel, Stefan, Laske, Christoph, Peters, Oliver, Düzel, Emrah, Wagner, Michael, Jiang, Jiehui, Jessen, Frank, Boecker, Henning, and Han, Ying

Subjects
hippocampus, Epidemiology, Health Policy, functional connectivity, 610 Medicine & health, insula, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, amyloid deposition, cross-cultural harmonization, ddc:610, Neurology (clinical), Centiloid, subjective cognitive decline, Geriatrics and Gerontology
Abstract

INTRODUCTION: It remains unclear whether functional brain networks are consistently altered in individuals with subjective cognitive decline (SCD) of diverse ethnic and cultural backgrounds and whether the network alterations are associated with an amyloid burden.METHODS: Cross-sectional resting-state functional magnetic resonance imaging connectivity (FC) and amyloid-positron emission tomography (PET) data from the Chinese Sino Longitudinal Study on Cognitive Decline and German DZNE Longitudinal Cognitive Impairment and Dementia cohorts were analyzed.RESULTS: Limbic FC, particularly hippocampal connectivity with right insula, was consistently higher in SCD than in controls, and correlated with SCD-plus features. Smaller SCD subcohorts with PET showed inconsistent amyloid positivity rates and FC-amyloid associations across cohorts.DISCUSSION: Our results suggest an early adaptation of the limbic network in SCD, which may reflect increased awareness of cognitive decline, irrespective of amyloid pathology. Different amyloid positivity rates may indicate a heterogeneous underlying etiology in Eastern and Western SCD cohorts when applying current research criteria. Future studies should identify culture-specific features to enrich preclinical Alzheimer's disease in non-Western populations.HIGHLIGHTS: Common limbic hyperconnectivity across Chinese and German subjective cognitive decline (SCD) cohorts was observed. Limbic hyperconnectivity may reflect awareness of cognition, irrespective of amyloid load. Further cross-cultural harmonization of SCD regarding Alzheimer's disease pathology is required.

Published
2023

48. Rhizarthrose

Author

Lerzer, Sebastian, Vafa, Morad Ali, Dechent, Peter, Tezval, Mohammad, Lotz, Joachim, Wachowski, Martin, Stürmer, Klaus Michael, and Dumont, Clemens

Abstract

Die Rhizarthrose ist eine fortschreitende Erkrankung, die nach röntgenologischen Kriterien in 4 Stadien eingeteilt wird. Klinisch korrelieren die Röntgenbefunde häufig nicht mit der bestehenden Symptomatik der betroffenen Patienten. In der vorliegenden Studie wurden Patienten mit einem Früh- und Spätstadium der Rhizarthrose verglichen und die klinische Symptomatik sowie konventionelle Röntgenaufnahmen einer erweiterten MRT-Untersuchung gegenübergestellt. Untersucht wurden 12 Patienten mit symptomatischer Rhizarthrose, 6 Patienten mit Stadium I nach Eaton/Littler vs. 6 Patienten mit Stadium III nach Eaton/Littler. Die standardisierte klinische Untersuchung wurde ergänzt durch eine 3-Tesla-MRT-Akquisition des Daumensattelgelenks in 4 Untersuchungspositionen des Daumens: Extension, Flexion, Abduktion, Adduktion. Beurteilt wurden 4 Ligamente, die dorsale und radiale Translation des 1. Mittelhandknochens (MHK I) sowie die Größe und Lokalisation von Osteophyten. Belastungsschmerzen und Kraftverlust sind Kennzeichen beider Stadien der Rhizarthrose. Bandläsionen betreffen v. a. das vordere Schrägband (AOL), nicht nur bei Patienten im Stadium III nach Eaton/Littler, sondern auch bereits in früheren Stadien der Rhizarthrose. Bei weiter fortgeschrittener Arthrose ist eine vergrößerte Translationsbewegung des MHK I nach dorsal erkennbar. Osteophyten > 2 mm treten v. a. radial sowie ulnar am Os trapezium auf. Die Röntgendiagnostik des Daumensattelgelenks erfasst nicht die bereits im Frühstadium der Rhizarthrose vorhandenen Bandläsionen. Dies ist insbesondere bei gelenkerhaltenen Operationsverfahren zu berücksichtigen. Zunehmende Häufigkeit und Kombinationen von Bandläsionen, aber auch eine dorsale Translation des MHK I, nicht eine radiale, sind Kennzeichen der fortgeschrittenen Rhizarthrose. Osteoarthritis of the first carpometacarpal joint (CMC I) is a progressive disease that is classified into four stages based on radiological criteria. Frequently, the X-ray does not correlate with the symptoms the patients present. In this study, we compared patients with early and advanced stages of CMC I osteoarthritis (OA) and evaluated clinical symptoms, X-ray results, and an advanced MRI examination. A total of 12 patients with CMC I OA were evaluated (6 Eaton/Littler stage I vs. 6 Eaton/Littler stage III). The clinical examination and X-ray was supplemented by a 3 T MRI in four thumb positions: extension, flexion, abduction, adduction. We assessed the four ligaments of CMC I, the dorsal and radial translation of the first metacarpal (MC I), and the location of osteophytes. Pain during strain and loss of power are characteristics of both stages of osteoarthritis of CMC I. Lesions of the ligaments include the anterior oblique ligament (AOL) and are present in both stage III according to Eaton/Littler and in early stages. In advanced stages of OA of CMC I, increased translation of MC I in a dorsal direction is observable. Osteophytes (> 2 mm) are commonly located at the trapezium at the radial and ulnar side. Clinical X-ray does not record the lesions of ligaments which are already visible in the MRI in an early stage of OA. This is important when joint-preserving surgery as ligament reconstruction or osteotomy is considered. Characteristics of advanced OA of CMC I are increasing frequency of isolated and also combined ligament lesions and dorsal, not a radial, translation of MC I.

Published
2024
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49. Postmortem quantitative MRI disentangles histological lesion types in multiple sclerosis.

Author

Galbusera, Riccardo, Bahn, Erik, Weigel, Matthias, Schaedelin, Sabine, Franz, Jonas, Lu, Po‐Jui, Barakovic, Muhamed, Melie‐Garcia, Lester, Dechent, Peter, Lutti, Antoine, Sati, Pascal, Reich, Daniel S., Nair, Govind, Brück, Wolfgang, Kappos, Ludwig, Stadelmann, Christine, and Granziera, Cristina

Subjects
MULTIPLE sclerosis, CENTRAL nervous system, WHITE matter (Nerve tissue), MAGNETIZATION transfer, MAGNETIC resonance imaging
Abstract

Quantitative MRI (qMRI) probes the microstructural properties of the central nervous system (CNS) by providing biophysical measures of tissue characteristics. In this work, we aimed to (i) identify qMRI measures that distinguish histological lesion types in postmortem multiple sclerosis (MS) brains, especially the remyelinated ones; and to (ii) investigate the relationship between those measures and quantitative histological markers of myelin, axons, and astrocytes in the same experimental setting. Three fixed MS whole brains were imaged with qMRI at 3T to obtain magnetization transfer ratio (MTR), myelin water fraction (MWF), quantitative T1 (qT1), quantitative susceptibility mapping (QSM), fractional anisotropy (FA) and radial diffusivity (RD) maps. The identification of lesion types (active, inactive, chronic active, or remyelinated) and quantification of tissue components were performed using histological staining methods as well as immunohistochemistry and immunofluorescence. Pairwise logistic and LASSO regression models were used to identify the best qMRI discriminators of lesion types. The association between qMRI and quantitative histological measures was performed using Spearman's correlations and linear mixed‐effect models. We identified a total of 65 lesions. MTR and MWF best predicted the chance of a lesion to be remyelinated, whereas RD and QSM were useful in the discrimination of active lesions. The measurement of microstructural properties through qMRI did not show any difference between chronic active and inactive lesions. MWF and RD were associated with myelin content in both lesions and normal‐appearing white matter (NAWM), FA was the measure most associated with axon content in both locations, while MWF was associated with astrocyte immunoreactivity only in lesions. Moreover, we provided evidence of extensive astrogliosis in remyelinated lesions. Our study provides new information on the discriminative power of qMRI in differentiating MS lesions ‐especially remyelinated ones‐ as well as on the relative association between multiple qMRI measures and myelin, axon and astrocytes. [ABSTRACT FROM AUTHOR]

Published
2023
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50. Long-term environmental enrichment is associated with better fornix microstructure in older adults.

Author

Klimecki, Olga M., Liebscher, Maxie, Gaubert, Malo, Hayek, Dayana, Zarucha, Alexis, Dyrba, Martin, Bartels, Claudia, Buerger, Katharina, Butryn, Michaela, Dechent, Peter, Dobisch, Laura, Ewers, Michael, Fliessbach, Klaus, Freiesleben, Silka Dawn, Glanz, Wenzel, Hetzer, Stefan, Janowitz, Daniel, Kilimann, Ingo, Kleineidam, Luca, and Laske, Christoph

Subjects
ALZHEIMER'S disease prevention, BRAIN physiology, LEISURE, STATISTICS, CONFIDENCE intervals, CROSS-sectional method, MAGNETIC resonance imaging, DESCRIPTIVE statistics, CHI-squared test, RESEARCH funding, DATA analysis software, COMPUTER-assisted image analysis (Medicine), DATA analysis, LONGITUDINAL method, OLD age
Abstract

Background: Sustained environmental enrichment (EE) through a variety of leisure activities may decrease the risk of developing Alzheimer’s disease. This cross-sectional cohort study investigated the association between long-term EE in young adulthood through middle life and microstructure of fiber tracts associated with the memory system in older adults. Methods: N = 201 cognitively unimpaired participants (≥ 60 years of age) from the DZNE-Longitudinal Cognitive Impairment and Dementia Study (DELCODE) baseline cohort were included. Two groups of participants with higher (n = 104) or lower (n = 97) long-term EE were identified, using the self-reported frequency of diverse physical, intellectual, and social leisure activities between the ages 13 to 65. White matter (WM) microstructure was measured by fractional anisotropy (FA) and mean diffusivity (MD) in the fornix, uncinate fasciculus, and parahippocampal cingulum using diffusion tensor imaging. Long-term EE groups (lower/higher) were compared with adjustment for potential confounders, such as education, crystallized intelligence, and socio-economic status. Results: Reported participation in higher long-term EE was associated with greater fornix microstructure, as indicated by higher FA (standardized β = 0.117, p = 0.033) and lower MD (β = −0.147, p = 0.015). Greater fornix microstructure was indirectly associated (FA: unstandardized B = 0.619, p = 0.038; MD: B = −0.035, p = 0.026) with better memory function through higher long-term EE. No significant effects were found for the other WM tracts. Conclusion: Our findings suggest that sustained participation in a greater variety of leisure activities relates to preserved WM microstructure in the memory system in older adults. This could be facilitated by the multimodal stimulation associated with the engagement in a physically, intellectually, and socially enriched lifestyle. Longitudinal studies will be needed to support this assumption. [ABSTRACT FROM AUTHOR]

Published
2023
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