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6. Gene-expression-based T-Cell-to-Stroma Enrichment (TSE) score predicts response to immune checkpoint inhibitors in urothelial cancer

Author

Rijnders, Maud, Nakauma-González, J. Alberto, Robbrecht, Debbie G. J., Gil-Jimenez, Alberto, Balcioglu, Hayri E., Oostvogels, Astrid A. M., Aarts, Maureen J. B., Boormans, Joost L., Hamberg, Paul, van der Heijden, Michiel S., Szabados, Bernadett E., van Leenders, Geert J. L. H., Mehra, Niven, Voortman, Jens, Westgeest, Hans M., de Wit, Ronald, van der Veldt, Astrid A. M., Debets, Reno, and Lolkema, Martijn P.

Published
2024
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10. Lipid-based nanosystems: the next generation of cancer immune therapy.

Author

Cheng, Ziyun, Fobian, Seth-Frerich, Gurrieri, Elena, Amin, Mohamadreza, D'Agostino, Vito Giuseppe, Falahati, Mojtaba, Zalba, Sara, Debets, Reno, Garrido, María J., Saeed, Mesha, Seynhaeve, Ann L. B., Balcioglu, Hayri E., and ten Hagen, Timo L. M.

Subjects
CANCER treatment, IMMUNE checkpoint inhibitors, IMMUNOREGULATION, CLINICAL medicine, NUCLEIC acids
Abstract

Immunotherapy has become an important part of the oncotherapy arsenal. Its applicability in various cancer types is impressive, as well as its use of endogenous mechanisms to achieve desired ends. However, off-target or on-target-off-tumor toxicity, limited activity, lack of control in combination treatments and, especially for solid tumors, low local accumulation, have collectively limited clinical use thereof. These limitations are partially alleviated by delivery systems. Lipid-based nanoparticles (NPs) have emerged as revolutionary carriers due to favorable physicochemical characteristics, with specific applications and strengths particularly useful in immunotherapeutic agent delivery. The aim of this review is to highlight the challenges faced by immunotherapy and how lipid-based NPs have been, and may be further utilized to address such challenges. We discuss recent fundamental and clinical applications of NPs in a range of areas and provide a detailed discussion of the main obstacles in immune checkpoint inhibition therapies, adoptive cellular therapies, and cytokine therapies. We highlight how lipid-based nanosystems could address these through either delivery, direct modulation of the immune system, or targeting of the immunosuppressive tumor microenvironment. We explore advanced and emerging liposomal and lipid nanoparticle (LNP) systems for nucleic acid delivery, intrinsic and extrinsic stimulus-responsive formulations, and biomimetic lipid-based nanosystems in immunotherapy. Finally, we discuss the key challenges relating to the clinical use of lipid-based NP immunotherapies, suggesting future research directions for the near term to realize the potential of these innovative lipid-based nanosystems, as they become the crucial steppingstone towards the necessary enhancement of the efficacy of immunotherapy. [ABSTRACT FROM AUTHOR]

Published
2024
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15. 361 T cell receptor specific for tumor-restricted Ropporin-1 to treat triple negative breast cancer

Author

Hammerl, Dora, primary, Kortleve, Dian, additional, Brakel, Mandy Van, additional, Wijers, Rebecca, additional, Roelofs, Daphne, additional, Badoux, Madelon, additional, Timmermans, Mieke A, additional, Liao, Anita C, additional, Michaux, Justine, additional, Beijer, Monique de, additional, Buschow, Sonja, additional, Danen, Erik, additional, Bassani-Sternberg, Michal, additional, Martens, John WM, additional, Abbott, Rachel JM, additional, and Debets, Reno, additional

Published
2023
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18. Identification of hepatocyte-restricted antigens, epitopes, and T cell receptors to treat recurrent hepatocellular carcinoma after liver transplantation

Author

Rakké, Yannick, primary, Kortleve, Dian, additional, Oostvogels, Astrid, additional, Luijten, Robbie, additional, de Beijer, Monique, additional, De Man, Stijn, additional, Doukas, Michael, additional, Ijzermans, Jan, additional, Buschow, Sonja, additional, Debets, Reno, additional, and Sprengers, Dave, additional

Published
2023
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21. T lymphocyte-derived IFN- facilitates breast cancer cells to pass the blood-brain barrier: an in vitro study corroborating translational data.

Author

Pedrosa, Rute M.S.M., primary, Kros, Johan M., additional, Schrijver, Benjamin, additional, Berrevoets, Cor, additional, Marques, Rute B., additional, Van Eijck, Casper C.H.J., additional, Debets, Reno, additional, Leenen, Pieter J.M., additional, Dik, Willem A., additional, and Mustafa, Dana A.M., additional

Published
2023
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23. Supplementary Figure S4 from T Cells Redirected to a Minor Histocompatibility Antigen Instruct Intratumoral TNFα Expression and Empower Adoptive Cell Therapy for Solid Tumors

Author

Manzo, Teresa, primary, Sturmheit, Tabea, primary, Basso, Veronica, primary, Petrozziello, Elisabetta, primary, Hess Michelini, Rodrigo, primary, Riba, Michela, primary, Freschi, Massimo, primary, Elia, Angela R., primary, Grioni, Matteo, primary, Curnis, Flavio, primary, Protti, Maria Pia, primary, Schumacher, Ton N., primary, Debets, Reno, primary, Swartz, Melody A., primary, Corti, Angelo, primary, Bellone, Matteo, primary, and Mondino, Anna, primary

Published
2023
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24. Supplementary Table S1 from T Cells Redirected to a Minor Histocompatibility Antigen Instruct Intratumoral TNFα Expression and Empower Adoptive Cell Therapy for Solid Tumors

Author

Manzo, Teresa, primary, Sturmheit, Tabea, primary, Basso, Veronica, primary, Petrozziello, Elisabetta, primary, Hess Michelini, Rodrigo, primary, Riba, Michela, primary, Freschi, Massimo, primary, Elia, Angela R., primary, Grioni, Matteo, primary, Curnis, Flavio, primary, Protti, Maria Pia, primary, Schumacher, Ton N., primary, Debets, Reno, primary, Swartz, Melody A., primary, Corti, Angelo, primary, Bellone, Matteo, primary, and Mondino, Anna, primary

Published
2023
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25. Supplementary figure 1 from Anti–PD-1 Efficacy in Patients with Metastatic Urothelial Cancer Associates with Intratumoral Juxtaposition of T Helper-Type 1 and CD8+ T cells

Author

Rijnders, Maud, primary, Balcioglu, Hayri E., primary, Robbrecht, Debbie G.J., primary, Oostvogels, Astrid A.M., primary, Wijers, Rebecca, primary, Aarts, Maureen J.B., primary, Hamberg, Paul, primary, van Leenders, Geert J.L.H., primary, Nakauma-González, J. Alberto, primary, Voortman, Jens, primary, Westgeest, Hans M., primary, Boormans, Joost L., primary, de Wit, Ronald, primary, Lolkema, Martijn P., primary, van der Veldt, Astrid A.M., primary, and Debets, Reno, primary

Published
2023
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26. Supplementary figure 3 from Anti–PD-1 Efficacy in Patients with Metastatic Urothelial Cancer Associates with Intratumoral Juxtaposition of T Helper-Type 1 and CD8+ T cells

Author

Rijnders, Maud, primary, Balcioglu, Hayri E., primary, Robbrecht, Debbie G.J., primary, Oostvogels, Astrid A.M., primary, Wijers, Rebecca, primary, Aarts, Maureen J.B., primary, Hamberg, Paul, primary, van Leenders, Geert J.L.H., primary, Nakauma-González, J. Alberto, primary, Voortman, Jens, primary, Westgeest, Hans M., primary, Boormans, Joost L., primary, de Wit, Ronald, primary, Lolkema, Martijn P., primary, van der Veldt, Astrid A.M., primary, and Debets, Reno, primary

Published
2023
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27. Supplementary table 2 from Anti–PD-1 Efficacy in Patients with Metastatic Urothelial Cancer Associates with Intratumoral Juxtaposition of T Helper-Type 1 and CD8+ T cells

Author

Rijnders, Maud, primary, Balcioglu, Hayri E., primary, Robbrecht, Debbie G.J., primary, Oostvogels, Astrid A.M., primary, Wijers, Rebecca, primary, Aarts, Maureen J.B., primary, Hamberg, Paul, primary, van Leenders, Geert J.L.H., primary, Nakauma-González, J. Alberto, primary, Voortman, Jens, primary, Westgeest, Hans M., primary, Boormans, Joost L., primary, de Wit, Ronald, primary, Lolkema, Martijn P., primary, van der Veldt, Astrid A.M., primary, and Debets, Reno, primary

Published
2023
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28. Supplementary figure legends from Anti–PD-1 Efficacy in Patients with Metastatic Urothelial Cancer Associates with Intratumoral Juxtaposition of T Helper-Type 1 and CD8+ T cells

Author

Rijnders, Maud, primary, Balcioglu, Hayri E., primary, Robbrecht, Debbie G.J., primary, Oostvogels, Astrid A.M., primary, Wijers, Rebecca, primary, Aarts, Maureen J.B., primary, Hamberg, Paul, primary, van Leenders, Geert J.L.H., primary, Nakauma-González, J. Alberto, primary, Voortman, Jens, primary, Westgeest, Hans M., primary, Boormans, Joost L., primary, de Wit, Ronald, primary, Lolkema, Martijn P., primary, van der Veldt, Astrid A.M., primary, and Debets, Reno, primary

Published
2023
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29. Supplementary Table and Figure Legends from T Cells Redirected to a Minor Histocompatibility Antigen Instruct Intratumoral TNFα Expression and Empower Adoptive Cell Therapy for Solid Tumors

Author

Manzo, Teresa, primary, Sturmheit, Tabea, primary, Basso, Veronica, primary, Petrozziello, Elisabetta, primary, Hess Michelini, Rodrigo, primary, Riba, Michela, primary, Freschi, Massimo, primary, Elia, Angela R., primary, Grioni, Matteo, primary, Curnis, Flavio, primary, Protti, Maria Pia, primary, Schumacher, Ton N., primary, Debets, Reno, primary, Swartz, Melody A., primary, Corti, Angelo, primary, Bellone, Matteo, primary, and Mondino, Anna, primary

Published
2023
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31. Supplementary figure 9 from Anti–PD-1 Efficacy in Patients with Metastatic Urothelial Cancer Associates with Intratumoral Juxtaposition of T Helper-Type 1 and CD8+ T cells

Author

Rijnders, Maud, primary, Balcioglu, Hayri E., primary, Robbrecht, Debbie G.J., primary, Oostvogels, Astrid A.M., primary, Wijers, Rebecca, primary, Aarts, Maureen J.B., primary, Hamberg, Paul, primary, van Leenders, Geert J.L.H., primary, Nakauma-González, J. Alberto, primary, Voortman, Jens, primary, Westgeest, Hans M., primary, Boormans, Joost L., primary, de Wit, Ronald, primary, Lolkema, Martijn P., primary, van der Veldt, Astrid A.M., primary, and Debets, Reno, primary

Published
2023
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32. Supplementary figure 6 from Anti–PD-1 Efficacy in Patients with Metastatic Urothelial Cancer Associates with Intratumoral Juxtaposition of T Helper-Type 1 and CD8+ T cells

Author

Rijnders, Maud, primary, Balcioglu, Hayri E., primary, Robbrecht, Debbie G.J., primary, Oostvogels, Astrid A.M., primary, Wijers, Rebecca, primary, Aarts, Maureen J.B., primary, Hamberg, Paul, primary, van Leenders, Geert J.L.H., primary, Nakauma-González, J. Alberto, primary, Voortman, Jens, primary, Westgeest, Hans M., primary, Boormans, Joost L., primary, de Wit, Ronald, primary, Lolkema, Martijn P., primary, van der Veldt, Astrid A.M., primary, and Debets, Reno, primary

Published
2023
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36. Supplementary figure 8 from Anti–PD-1 Efficacy in Patients with Metastatic Urothelial Cancer Associates with Intratumoral Juxtaposition of T Helper-Type 1 and CD8+ T cells

Author

Rijnders, Maud, primary, Balcioglu, Hayri E., primary, Robbrecht, Debbie G.J., primary, Oostvogels, Astrid A.M., primary, Wijers, Rebecca, primary, Aarts, Maureen J.B., primary, Hamberg, Paul, primary, van Leenders, Geert J.L.H., primary, Nakauma-González, J. Alberto, primary, Voortman, Jens, primary, Westgeest, Hans M., primary, Boormans, Joost L., primary, de Wit, Ronald, primary, Lolkema, Martijn P., primary, van der Veldt, Astrid A.M., primary, and Debets, Reno, primary

Published
2023
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38. Supplementary figure 2 from Anti–PD-1 Efficacy in Patients with Metastatic Urothelial Cancer Associates with Intratumoral Juxtaposition of T Helper-Type 1 and CD8+ T cells

Author

Rijnders, Maud, primary, Balcioglu, Hayri E., primary, Robbrecht, Debbie G.J., primary, Oostvogels, Astrid A.M., primary, Wijers, Rebecca, primary, Aarts, Maureen J.B., primary, Hamberg, Paul, primary, van Leenders, Geert J.L.H., primary, Nakauma-González, J. Alberto, primary, Voortman, Jens, primary, Westgeest, Hans M., primary, Boormans, Joost L., primary, de Wit, Ronald, primary, Lolkema, Martijn P., primary, van der Veldt, Astrid A.M., primary, and Debets, Reno, primary

Published
2023
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39. Supplementary figure 7 from Anti–PD-1 Efficacy in Patients with Metastatic Urothelial Cancer Associates with Intratumoral Juxtaposition of T Helper-Type 1 and CD8+ T cells

Author

Rijnders, Maud, primary, Balcioglu, Hayri E., primary, Robbrecht, Debbie G.J., primary, Oostvogels, Astrid A.M., primary, Wijers, Rebecca, primary, Aarts, Maureen J.B., primary, Hamberg, Paul, primary, van Leenders, Geert J.L.H., primary, Nakauma-González, J. Alberto, primary, Voortman, Jens, primary, Westgeest, Hans M., primary, Boormans, Joost L., primary, de Wit, Ronald, primary, Lolkema, Martijn P., primary, van der Veldt, Astrid A.M., primary, and Debets, Reno, primary

Published
2023
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41. Supplementary Methods and References. from T Cells Redirected to a Minor Histocompatibility Antigen Instruct Intratumoral TNFα Expression and Empower Adoptive Cell Therapy for Solid Tumors

Author

Manzo, Teresa, primary, Sturmheit, Tabea, primary, Basso, Veronica, primary, Petrozziello, Elisabetta, primary, Hess Michelini, Rodrigo, primary, Riba, Michela, primary, Freschi, Massimo, primary, Elia, Angela R., primary, Grioni, Matteo, primary, Curnis, Flavio, primary, Protti, Maria Pia, primary, Schumacher, Ton N., primary, Debets, Reno, primary, Swartz, Melody A., primary, Corti, Angelo, primary, Bellone, Matteo, primary, and Mondino, Anna, primary

Published
2023
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42. Supplementary table 1 from Anti–PD-1 Efficacy in Patients with Metastatic Urothelial Cancer Associates with Intratumoral Juxtaposition of T Helper-Type 1 and CD8+ T cells

Author

Rijnders, Maud, primary, Balcioglu, Hayri E., primary, Robbrecht, Debbie G.J., primary, Oostvogels, Astrid A.M., primary, Wijers, Rebecca, primary, Aarts, Maureen J.B., primary, Hamberg, Paul, primary, van Leenders, Geert J.L.H., primary, Nakauma-González, J. Alberto, primary, Voortman, Jens, primary, Westgeest, Hans M., primary, Boormans, Joost L., primary, de Wit, Ronald, primary, Lolkema, Martijn P., primary, van der Veldt, Astrid A.M., primary, and Debets, Reno, primary

Published
2023
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43. Supplementary figure 4 from Anti–PD-1 Efficacy in Patients with Metastatic Urothelial Cancer Associates with Intratumoral Juxtaposition of T Helper-Type 1 and CD8+ T cells

Author

Rijnders, Maud, primary, Balcioglu, Hayri E., primary, Robbrecht, Debbie G.J., primary, Oostvogels, Astrid A.M., primary, Wijers, Rebecca, primary, Aarts, Maureen J.B., primary, Hamberg, Paul, primary, van Leenders, Geert J.L.H., primary, Nakauma-González, J. Alberto, primary, Voortman, Jens, primary, Westgeest, Hans M., primary, Boormans, Joost L., primary, de Wit, Ronald, primary, Lolkema, Martijn P., primary, van der Veldt, Astrid A.M., primary, and Debets, Reno, primary

Published
2023
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44. Data from Anti–PD-1 Efficacy in Patients with Metastatic Urothelial Cancer Associates with Intratumoral Juxtaposition of T Helper-Type 1 and CD8+ T cells

Author

Rijnders, Maud, primary, Balcioglu, Hayri E., primary, Robbrecht, Debbie G.J., primary, Oostvogels, Astrid A.M., primary, Wijers, Rebecca, primary, Aarts, Maureen J.B., primary, Hamberg, Paul, primary, van Leenders, Geert J.L.H., primary, Nakauma-González, J. Alberto, primary, Voortman, Jens, primary, Westgeest, Hans M., primary, Boormans, Joost L., primary, de Wit, Ronald, primary, Lolkema, Martijn P., primary, van der Veldt, Astrid A.M., primary, and Debets, Reno, primary

Published
2023
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46. Supplementary figure 5 from Anti–PD-1 Efficacy in Patients with Metastatic Urothelial Cancer Associates with Intratumoral Juxtaposition of T Helper-Type 1 and CD8+ T cells

Author

Rijnders, Maud, primary, Balcioglu, Hayri E., primary, Robbrecht, Debbie G.J., primary, Oostvogels, Astrid A.M., primary, Wijers, Rebecca, primary, Aarts, Maureen J.B., primary, Hamberg, Paul, primary, van Leenders, Geert J.L.H., primary, Nakauma-González, J. Alberto, primary, Voortman, Jens, primary, Westgeest, Hans M., primary, Boormans, Joost L., primary, de Wit, Ronald, primary, Lolkema, Martijn P., primary, van der Veldt, Astrid A.M., primary, and Debets, Reno, primary

Published
2023
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48. Supplementary Methods, Figures 1-3 from Reprogramming T Lymphocytes for Melanoma Adoptive Immunotherapy by T-Cell Receptor Gene Transfer with Lentiviral Vectors

Author

Bobisse, Sara, primary, Rondina, Maria, primary, Merlo, Anna, primary, Tisato, Veronica, primary, Mandruzzato, Susanna, primary, Amendola, Mario, primary, Naldini, Luigi, primary, Willemsen, Ralph A., primary, Debets, Reno, primary, Zanovello, Paola, primary, and Rosato, Antonio, primary

Published
2023
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49. Frequency of Peripheral CD8+ T Cells Expressing Chemo-Attractant Receptors CCR1, 4 and 5 Increases in NPC Patients with EBV Clearance upon Radiotherapy

Author

Mahajan, Shweta, primary, Balcioglu, Hayri E., additional, Oostvogels, Astrid, additional, Dik, Willem A., additional, Chan, K. C. Allen, additional, Lo, Kwok-Wai, additional, Hui, Edwin P., additional, Tsang, Anna, additional, Tong, Joanna, additional, Lam, Wai Kei Jacky, additional, Wong, Kenneth, additional, Chan, Anthony T. C., additional, Ma, Brigette B. Y., additional, and Debets, Reno, additional

Published
2023
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