30 results on '"Debacker, W"'
Search Results
2. Implications of using systematic decomposition structures to organize building LCA information: A comparative analysis of national standards and guidelines - IEA EBC ANNEX 72
- Author
-
Universidad de Sevilla. Departamento de Construcciones Arquitectónicas I (ETSA), Universidad de Sevilla. TEP986: Digital Architecture for Sustainability Lab (Datus-Lab), Universidad de Sevilla. TEP130: Arquitectura, Patrimonio y Sostenibilidad: Acústica, Iluminación, Óptica y Energía, Soust-Verdaguer, Bernardette, García Martínez, Antonio, Llatas, Carmen, Gómez de Cózar, Juan Carlos, Allacker, K., Trigaux, D., Alsema, E., Berg, B., Dowdell, D., Debacker, W., Frischknecht, R., Ramseier, L., Veselka, J., Volf, M., Hajek, P., Lupíšek, A., Malik, Z., Habert, G., Hollberg, A., Lasvaux, S., Peuportier, B., Pomponi, F., Wastiel, L., Gomes, V., Zara, O., Gomes, M., Gusson Baiocchi, A., Pulgrossi, L., Ouellet-Plamondon, Claudiane, Moncaster, A., Di Bari, R., Horn, R., Lenz, K., Balouktsi, M., Lützkendorf, T., Röck, M., Hoxha, E., Passer, A., Universidad de Sevilla. Departamento de Construcciones Arquitectónicas I (ETSA), Universidad de Sevilla. TEP986: Digital Architecture for Sustainability Lab (Datus-Lab), Universidad de Sevilla. TEP130: Arquitectura, Patrimonio y Sostenibilidad: Acústica, Iluminación, Óptica y Energía, Soust-Verdaguer, Bernardette, García Martínez, Antonio, Llatas, Carmen, Gómez de Cózar, Juan Carlos, Allacker, K., Trigaux, D., Alsema, E., Berg, B., Dowdell, D., Debacker, W., Frischknecht, R., Ramseier, L., Veselka, J., Volf, M., Hajek, P., Lupíšek, A., Malik, Z., Habert, G., Hollberg, A., Lasvaux, S., Peuportier, B., Pomponi, F., Wastiel, L., Gomes, V., Zara, O., Gomes, M., Gusson Baiocchi, A., Pulgrossi, L., Ouellet-Plamondon, Claudiane, Moncaster, A., Di Bari, R., Horn, R., Lenz, K., Balouktsi, M., Lützkendorf, T., Röck, M., Hoxha, E., and Passer, A.
- Abstract
The application of the Life Cycle Assessment (LCA) technique to a building requires the collection and organization of a large amount of data over its life cycle. The systematic decomposition method can be used to classify building components, elements and materials, overcome specific difficulties that are encountered when attempting to complete the life cycle inventory and increase the reliability and transparency of results. In this paper, which was developed in the context of the research project IEA EBC Annex 72, we demonstrate the implications of taking such approach and describe the results of a comparison among different national standards/guidelines that are used to conduct LCA for building decomposition. Methods: We initially identified the main characteristics of the standards/guidelines used by Annex participant countries. The "be2226" reference office building was used as a reference to apply the different national standards/guidelines related to building decomposition. It served as a basis of comparison, allowing us to identify the implications of using different systems/standards in the LCA practice, in terms of how these differences affect the LCI structures, LCA databases and the methods used to communicate results. We also analyzed the implications of integrating these standards/guidelines into Building Information Modelling (BIM) to support LCA. Results: Twelve national classification systems/standards/guidelines for the building decomposition were compared. Differences were identified among the levels of decomposition and grouping principles, as well as the consequences of these differences that were related to the LCI organization. In addition, differences were observed among the LCA databases and the structures of the results. Conclusions: The findings of this study summarize and provide an overview of the most relevant aspects of using a standardized building decomposition structure to conduct LCA. Recommendations are formulated on the basis of
- Published
- 2020
3. Four-Dimensional Design: From Strategies to Cases – Generation of Fractal Grammar for Reusing Building Elements
- Author
-
Debacker, W., primary, Henrotay, C., additional, Paduart, A., additional, Elsen, S., additional, De Wilde, W. P., additional, and Hendrickx, H., additional
- Published
- 2011
- Full Text
- View/download PDF
4. Environmental benchmarks for buildings: a critical literature review
- Author
-
Trigaux, D., primary, Allacker, K., additional, and Debacker, W., additional
- Published
- 2020
- Full Text
- View/download PDF
5. Implications of using systematic decomposition structures to organize building LCA information: A comparative analysis of national standards and guidelines- IEA EBC ANNEX 72
- Author
-
Soust-Verdaguer, B, primary, García Martínez, A, additional, Llatas, C, additional, Gómez de Cózar, J.C., additional, Allacker, K, additional, Trigaux, D, additional, Alsema, E, additional, Berg, B, additional, Dowdell, D, additional, Debacker, W, additional, Frischknecht, R, additional, Ramseier, L, additional, Veselka, J, additional, Volf, M, additional, Hajek, P, additional, Lupíšek, A, additional, Malik, Z, additional, Habert, G, additional, Hollberg, A, additional, Lasvaux, S, additional, Peuportier, B, additional, Pomponi, F, additional, Wastiel, L, additional, Gomes, V, additional, Zara, O, additional, Gomes, M, additional, Gusson Baiocchi, A, additional, Pulgrossi, L, additional, Ouellet-Plamondon, C, additional, Moncaster, A, additional, Di Bari, R, additional, Horn, R, additional, Lenz, K, additional, Balouktsi, M, additional, Lützkendorf, T, additional, Röck, M, additional, Hoxha, E, additional, and Passer, A, additional
- Published
- 2020
- Full Text
- View/download PDF
6. Critical analysis of environmental benchmarks for buildings
- Author
-
Trigaux, D, primary, Allacker, K, additional, and Debacker, W, additional
- Published
- 2019
- Full Text
- View/download PDF
7. Consequential LCA of demountable and reusable internal wall assemblies: a case study in a Belgian context
- Author
-
Buyle, M, primary, Galle, W, additional, Debacker, W, additional, and Audenaert, A, additional
- Published
- 2019
- Full Text
- View/download PDF
8. Why invest in a reversible building design?
- Author
-
Wang, K, primary, de Regel, S, additional, Debacker, W, additional, Michiels, J, additional, and Vanderheyden, J, additional
- Published
- 2019
- Full Text
- View/download PDF
9. Central apnea index decreases after prolonged treatment with acetazolamide.
- Author
-
DeBacker, W A, Verbraecken, J, Willemen, M, Wittesaele, W, DeCock, W, and Van deHeyning, P
- Published
- 1995
- Full Text
- View/download PDF
10. How do current policies support a transition towards a circular economy in the built environment?
- Author
-
Henrotay, C. (author), Debacker, W. (author), Steinlage, Molly (author), Henrotay, C. (author), Debacker, W. (author), and Steinlage, Molly (author)
- Abstract
Building and construction industry consumes huge quantities of materials in an unsustainable way. As a result of a linear design approach and economic model, at the end of use, but also throughout the cycle, buildings or parts of buildings are demolished and remnants treated as waste or –best case– down-cycled. This creation of waste as well as the use of virgin resources leads to an important environmental, economic and societal impact. To create a sustainable build environment, the building sector needs to move towards a circular economy in which circular and dynamic buildings as well as their component and materials preserve value. Policies and regulations in member states and across the EU will influence the ability to transition to a circular economy – positively and negatively. Within the H2020 Buildings As Materials Banks (BAMB) Project work is underway to understand where the opportunities and barriers lie in a complex and, sometimes contradictory, regulatory landscape. This paper presents an overview of the current policy instruments that are considered to have relevance in relation to promoting, or possibly hindering, the adoption of circular economy opportunities in the built environment. The analysis of the current policy instruments has been done on a European level and on a member state level for 4 different countries being: Belgium, Portugal, Sweden and UK. The paper will mainly focus on the European Level and Belgium.
- Published
- 2017
11. The European sleep apnoea database (ESADA) –report from 22 European sleep laboratories
- Author
-
Hedner, J, Grote, L, Bonsignore, M, Mcnicholas, W, Lavie, P, Parati, G, Sliwinski, P, Barbé, F, Escourrou, P, Fietze, I, Masa, J, Kvamme, J, Lombardi, C, Marrone, O, Montserrat, J, Penzel, T, Pretl, M, Riha, R, Rodenstein, D, Saaresranta, T, Schulz, R, Tkacova, R, Varoneckas, G, Vitols, A, Vrints, H, Zielinski, J, Debacker, W, McNicholas, W, Masa, JF, Kvamme, JA, Montserrat, JM, Debacker, W., PARATI, GIANFRANCO, LOMBARDI, CAROLINA, Hedner, J, Grote, L, Bonsignore, M, Mcnicholas, W, Lavie, P, Parati, G, Sliwinski, P, Barbé, F, Escourrou, P, Fietze, I, Masa, J, Kvamme, J, Lombardi, C, Marrone, O, Montserrat, J, Penzel, T, Pretl, M, Riha, R, Rodenstein, D, Saaresranta, T, Schulz, R, Tkacova, R, Varoneckas, G, Vitols, A, Vrints, H, Zielinski, J, Debacker, W, McNicholas, W, Masa, JF, Kvamme, JA, Montserrat, JM, Debacker, W., PARATI, GIANFRANCO, and LOMBARDI, CAROLINA
- Abstract
The European Sleep Apnoea Database (ESADA) reflects a network of 22 sleep disorder centres in Europe enabled by a COST action B26 programme. This ongoing project aims to describe differences in standard clinical care of patients with obstructive sleep apnoea (OSA) and to establish a resource for genetic research in this disorder. Patients with suspected OSA are consecutively included and followed up according to local clinical standards. Anthropometrics, medical history, medication, daytime symptoms and sleep data (polysomnography or cardiorespiratory polygraphy) are recorded in a structured web-based report form. 5,103 patients (1,426 females, mean¡SD age 51.8¡12.6 yrs, 79.4% with apnoea/hypopnoea index (AHI) o5 events?h-1) were included from March 15, 2007 to August 1, 2009. Morbid obesity (body mass index o35 kg?m-2) was present in 21.1% of males and 28.6% of females. Cardiovascular, metabolic and pulmonary comorbidities were frequent (49.1%, 32.9% and 14.2%, respectively). Patients investigated with a polygraphic method had a lower AHI than those undergoing polysomnography (23.2¡23.5 versus 29.1¡26.3 events?h-1, p,0.0001). The ESADA is a rapidly growing multicentre patient cohort that enables unique outcome research opportunities and genotyping. The first cross-sectional analysis reveals a high prevalence of cardiovascular and metabolic morbidity in patients investigated for OSA.
- Published
- 2011
12. Structural optimisation and sustainable design
- Author
-
De Wilde, W.P., primary, Vandenbergh, T., additional, and Debacker, W., additional
- Published
- 2015
- Full Text
- View/download PDF
13. An integrated approach for financial and environmental cost optimisation of heating services
- Author
-
Debacker, W. (author), Allacker, K. (author), Delem, L. (author), Janssen, A. (author), De Troyer, F. (author), Spirinckx, C. (author), Geerken, T. (author), Van Dessel, J. (author), Debacker, W. (author), Allacker, K. (author), Delem, L. (author), Janssen, A. (author), De Troyer, F. (author), Spirinckx, C. (author), Geerken, T. (author), and Van Dessel, J. (author)
- Abstract
A four-year project has started in 2007 to develop a methodology that can be applied to optimize the Belgian dwelling stock. The aim of the project is to optimise buildings concerning their environmental impact, their financial cost and the quality they offer over the whole life cycle, from the production of primary raw materials to the final demolition and end-of-life treatment. In the first phase of the project the optimisation methodology is developed; i.e. environmental impacts are analysed by means of life cycle assessment (LCA); financial costs are calculated based on life cycle cost analyses (LCC); and the quality evaluation is based on multi-criteria analyses (MCA). The aim of the optimization is to realize the highest marginal quality improvement for the additional financial and environmental cost. In a second phase the developed methodology is translated into a work instrument and applied to different dwelling types. This paper goes more deeply into the role heating services play in the environmental and financial costs. For a typical Belgian dwelling initial and life cycle costs for commonly used as well as advanced heating configurations are compared. Since energy consumption for heating is dependent of the way the building envelope is built, the analysis is performed on two dwelling configurations with a different insulation level.
- Published
- 2010
14. Re-design for change: environmental and financial assessment of a dynamic renovation approach for residential buildings
- Author
-
Paduart, A., primary, Debacker, W., additional, De Temmerman, N., additional, De Wilde, W. P., additional, and Hendrickx, H., additional
- Published
- 2011
- Full Text
- View/download PDF
15. Technical detailing principles for the design of adaptable and reusable construction elements in temporary dwellings
- Author
-
Paduart, A., primary, Debacker, W., additional, Henrotay, C., additional, Asnong, K., additional, De Wilde, W. P., additional, and Hendrickx, H., additional
- Published
- 2008
- Full Text
- View/download PDF
16. Four-dimensional design: from strategies to cases – generation of fractal grammar for reusing building elements
- Author
-
Debacker, W., primary, Henrotay, C., additional, Paduart, A., additional, Elsen, S., additional, De Wilde, W.P., additional, and Hendrickx, H., additional
- Published
- 2008
- Full Text
- View/download PDF
17. Adaptable versus lightweight design of transitory dwellings
- Author
-
Debacker, W., primary, Henrotay, C., additional, de Wilde, W. P., additional, and Hendrickx, H., additional
- Published
- 2006
- Full Text
- View/download PDF
18. 4-dimensional design: a design strategy for efficient shelter and sustainable housing after conflict-based and natural disasters
- Author
-
Henrotay, C., primary, Debacker, W., additional, Mollaert, M., additional, de Wilde, W. P., additional, and Hendrickx, H., additional
- Published
- 2006
- Full Text
- View/download PDF
19. Antioxidant defence during cardiopulmonary bypass surgery
- Author
-
LUYTEN, C, primary, VANOVERVELD, F, additional, DEBACKER, L, additional, SADOWSKA, A, additional, RODRIGUS, I, additional, DEHERT, S, additional, and DEBACKER, W, additional
- Published
- 2005
- Full Text
- View/download PDF
20. 582 Severity of obstructive sleep apnea syndrome is associated with right heart function
- Author
-
SHIVALKAR, B, primary, KERREMANS, M, additional, VANDEHEYNING, C, additional, RINKEVICH, D, additional, VERBRAECKEM, J, additional, DEBACKER, W, additional, and VRINTS, C, additional
- Published
- 2003
- Full Text
- View/download PDF
21. Daytime sleepiness, snoring and gastroesophageal reflux among young adults in three European countries.
- Author
-
Janson, C, Gislason, T, DeBacker, W, Plaschke, P, Bjornsson, E, Hetta, J, Kristbjarnason, H, Vermeire, P, Boman, G, Janson, C, Gislason, T, DeBacker, W, Plaschke, P, Bjornsson, E, Hetta, J, Kristbjarnason, H, Vermeire, P, and Boman, G
- Published
- 1995
22. Two years treatment with almitrine bismesylate in patients with hypoxic chronic obstructive airways disease
- Author
-
Bardsley, PA, primary, Howard, P, additional, DeBacker, W, additional, Vermeire, P, additional, Mairesse, M, additional, Ledent, C, additional, Radermecker, M, additional, Bury, T, additional, and Ansquer, J, additional
- Published
- 1991
- Full Text
- View/download PDF
23. Implications of using systematic decomposition structures to organize building LCA information: A comparative analysis of national standards and guidelines - IEA EBC ANNEX 72
- Author
-
Soust-Verdaguer, B., García Martínez, A., Llatas, C., Gómez de Cózar, J.C., Allacker, K., Trigaux, D., Alsema, E., Berg, B., Dowdell, D., Debacker, W., Frischknecht, R., Ramseier, L., Veselka, J., Volf, M., Hajek, P., Lupíšek, A., Malik, Z., Habert, G., Hollberg, A., Lasvaux, S., Peuportier, B., Pomponi, F., Wastiel, L., Gomes, V., Zara, O., Gomes, M., Gusson Baiocchi, A., Pulgrossi, L., Ouellet-Plamondon, C., Moncaster, A., Di Bari, R., Horn, R., Lenz, K., Balouktsi, M., Lützkendorf, T., Röck, M., Hoxha, E., Passer, A., Soust-Verdaguer, B., García Martínez, A., Llatas, C., Gómez de Cózar, J.C., Allacker, K., Trigaux, D., Alsema, E., Berg, B., Dowdell, D., Debacker, W., Frischknecht, R., Ramseier, L., Veselka, J., Volf, M., Hajek, P., Lupíšek, A., Malik, Z., Habert, G., Hollberg, A., Lasvaux, S., Peuportier, B., Pomponi, F., Wastiel, L., Gomes, V., Zara, O., Gomes, M., Gusson Baiocchi, A., Pulgrossi, L., Ouellet-Plamondon, C., Moncaster, A., Di Bari, R., Horn, R., Lenz, K., Balouktsi, M., Lützkendorf, T., Röck, M., Hoxha, E., and Passer, A.
- Abstract
Introduction: The application of the Life Cycle Assessment (LCA) technique to a building requires the collection and organization of a large amount of data over its life cycle. The systematic decomposition method can be used to classify building components, elements and materials, overcome specific difficulties that are encountered when attempting to complete the life cycle inventory and increase the reliability and transparency of results. In this paper, which was developed in the context of the research project IEA EBC Annex 72, we demonstrate the implications of taking such approach and describe the results of a comparison among different national standards/guidelines that are used to conduct LCA for building decomposition. Methods: We initially identified the main characteristics of the standards/guidelines used by Annex participant countries. The “be2226” reference office building was used as a reference to apply the different national standards/guidelines related to building decomposition. It served as a basis of comparison, allowing us to identify the implications of using different systems/standards in the LCA practice, in terms of how these differences affect the LCI structures, LCA databases and the methods used to communicate results. We also analyzed the implications of integrating these standards/guidelines into Building Information Modelling (BIM) to support LCA. Results: Twelve national classification systems/standards/guidelines for the building decomposition were compared. Differences were identified among the levels of decomposition and grouping principles, as well as the consequences of these differences that were related to the LCI organization. In addition, differences were observed among the LCA databases and the structures of the results. Conclusions: The findings of this study summarize and provide an overview of the most relevant aspects of using a standardized building decomposition stru
24. Implications of using systematic decomposition structures to organize building LCA information: A comparative analysis of national standards and guidelines - IEA EBC ANNEX 72
- Author
-
Soust-Verdaguer, B., García Martínez, A., Llatas, C., Gómez de Cózar, J.C., Allacker, K., Trigaux, D., Alsema, E., Berg, B., Dowdell, D., Debacker, W., Frischknecht, R., Ramseier, L., Veselka, J., Volf, M., Hajek, P., Lupíšek, A., Malik, Z., Habert, G., Hollberg, A., Lasvaux, S., Peuportier, B., Pomponi, F., Wastiel, L., Gomes, V., Zara, O., Gomes, M., Gusson Baiocchi, A., Pulgrossi, L., Ouellet-Plamondon, C., Moncaster, A., Di Bari, R., Horn, R., Lenz, K., Balouktsi, M., Lützkendorf, T., Röck, M., Hoxha, E., Passer, A., Soust-Verdaguer, B., García Martínez, A., Llatas, C., Gómez de Cózar, J.C., Allacker, K., Trigaux, D., Alsema, E., Berg, B., Dowdell, D., Debacker, W., Frischknecht, R., Ramseier, L., Veselka, J., Volf, M., Hajek, P., Lupíšek, A., Malik, Z., Habert, G., Hollberg, A., Lasvaux, S., Peuportier, B., Pomponi, F., Wastiel, L., Gomes, V., Zara, O., Gomes, M., Gusson Baiocchi, A., Pulgrossi, L., Ouellet-Plamondon, C., Moncaster, A., Di Bari, R., Horn, R., Lenz, K., Balouktsi, M., Lützkendorf, T., Röck, M., Hoxha, E., and Passer, A.
- Abstract
Introduction: The application of the Life Cycle Assessment (LCA) technique to a building requires the collection and organization of a large amount of data over its life cycle. The systematic decomposition method can be used to classify building components, elements and materials, overcome specific difficulties that are encountered when attempting to complete the life cycle inventory and increase the reliability and transparency of results. In this paper, which was developed in the context of the research project IEA EBC Annex 72, we demonstrate the implications of taking such approach and describe the results of a comparison among different national standards/guidelines that are used to conduct LCA for building decomposition. Methods: We initially identified the main characteristics of the standards/guidelines used by Annex participant countries. The “be2226” reference office building was used as a reference to apply the different national standards/guidelines related to building decomposition. It served as a basis of comparison, allowing us to identify the implications of using different systems/standards in the LCA practice, in terms of how these differences affect the LCI structures, LCA databases and the methods used to communicate results. We also analyzed the implications of integrating these standards/guidelines into Building Information Modelling (BIM) to support LCA. Results: Twelve national classification systems/standards/guidelines for the building decomposition were compared. Differences were identified among the levels of decomposition and grouping principles, as well as the consequences of these differences that were related to the LCI organization. In addition, differences were observed among the LCA databases and the structures of the results. Conclusions: The findings of this study summarize and provide an overview of the most relevant aspects of using a standardized building decomposition stru
25. Sleep HERMES: a European Core Syllabus in respiratory disorders during sleep
- Author
-
Walter T. McNicholas, Johan Verbraecken, Maria R. Bonsignore, Anita K. Simonds, Viliam Donic, Stefan Andreas, Patrick Levy, Renata L. Riha, W. De Backer, Mary J. Morrell, Pma Calverley, V. Horn, Winfried Randerath, Sharon Mitchell, Ha Trang, Paolo Palange, DeBacker, W, Simonds, AK, Horn, V, Andreas, S, Bonsignore, M, Calverley, P, Donic, V, Levy, P, Mitchell, S, McNicholas, WT, Morrell, M, Randerath, W, Riha, RL, Trang, H, Verbraecken, J, and Palange P
- Subjects
Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Teaching program ,sleep disordered breathing ,Psychological intervention ,Certification ,Biology ,Settore MED/10 - Malattie Dell'Apparato Respiratorio ,Sleep medicine ,Syllabus ,Respiratory Medicine ,Documentation ,Family medicine ,Epidemiology ,medicine ,Sleep (system call) ,Human medicine - Abstract
The clinical characterisation and description of the obstructive sleep apnoea–hypopnoea syndrome (OSAHS) and related syndromes were mainly revealed by several epidemiological studies conducted over the past fifty years. These highly prevalent syndromes affect about 9% of middle-aged men and 4% of women. These syndromes have serious medical and social consequences, such as cardiovascular or metabolic diseases, and even premature death. Consequently, respiratory sleep medicine (RSM) evolved and has progressed rapidly within the sleep medicine field over recent decades. New diagnostic and therapeutic techniques have appeared in response to an increasing number of patients and clinical interventions. The research progressed to focus not only on the clinical and pathophysiological but also the genetic and molecular aspects of these syndromes [1–6]. Nevertheless, the literature in the field does not provide any clear consensus on diagnostic classification and assessment. No harmonised standards of training exist across Europe for respiratory sleep medicine. The European Respiratory Society (ERS) provided external and postgraduate courses but the requirements and expectations in the field were not being fulfilled. There was a need for a project supporting both the teaching and certification. For this reason, ERS supported an application for a Sleep Harmonised Education in Respiratory Medicine for European Specialists (HERMES) Task Force project which aimed at establishing common standards in respiratory sleep training and education, in an adaptable framework which can be extended across Europe. HERMES was a project established in 2005 to provide documentation for the training and certification of adult respiratory specialists. Since 2005, the HERMES framework has been adapted for projects including paediatric respiratory medicine, critical care medicine and the development of the European Spirometry Driving Licence (spirometry). Within the HERMES model, a process of establishing consensus standards for training largely follows four key phases (fig. 1). In line with this …
- Published
- 2011
26. Sleep HERMES: a European training project for respiratory sleep medicine
- Author
-
Patrick Levy, Renata L. Riha, V. Horn, Johan Verbraecken, W. De Backer, Walter T. McNicholas, Mary J. Morrell, Winfried Randerath, Paolo Palange, Viliam Donic, Sharon Mitchell, Stefan Andreas, Maria R. Bonsignore, Anita K. Simonds, Peter M. A. Calverley, Ha Trang, DeBacker, W, Simonds, AK, Horn, V, Andreas, S, Bonsignore, MR, Calverley, P, Donic, V, Levy, P, Mitchell, S, McNicholas, WT, Morrell, M, Randerath, W, Riha, RL, Trang, H, Verbraecken, J, and Palange, P
- Subjects
Pulmonary and Respiratory Medicine ,Male ,medicine.medical_specialty ,Pediatrics ,Specialty ,Psychological intervention ,Settore MED/10 - Malattie Dell'Apparato Respiratorio ,Training (civil) ,Sleep medicine ,Epidemiology ,medicine ,Pulmonary Medicine ,Humans ,Program Development ,Sleep Apnea, Obstructive ,business.industry ,Sleep in non-human animals ,Diagnostic classification ,Sleep, training, respiratory, European project ,Europe ,Education, Medical, Graduate ,Family medicine ,Social consequence ,Education, Medical, Continuing ,Female ,Human medicine ,Curriculum ,business - Abstract
The clinical characterisation and description of the obstructive sleep apnoea/hypopnoea syndrome (OSAHS) and related syndromes have been revealed by several epidemiological studies conducted in the late 20th and 21st centuries. These highly prevalent syndromes affect about 9% of middle-aged males and 4% of females. These syndromes have serious medical and social consequences, such as cardiovascular or metabolic diseases and even premature death. Consequently, respiratory sleep medicine has evolved and progressed rapidly within the sleep medicine field over the last decades. New diagnostic and therapeutic techniques appeared in response to an increasing number of patients and clinical interventions. The research progressed to focus not only on the clinical and pathophysiological, but also on the genetic and molecular aspects of these syndromes [1–4]. Nevertheless, the literature in the field does not provide any clear consensus on diagnostic classification and assessment. No harmonised standards of training exist across Europe for respiratory sleep medicine. The European Respiratory Society (ERS) conducted a survey in 2010 to enquire about the structure and organisation of training in different countries within Europe. National experts in the field of respiratory sleep medicine from 21 different countries were consulted. They were first asked about the duration of training in respiratory disorders during sleep. A huge diversity in training organisations and durations was revealed. Across 18 collected responses, it was observed that nine countries do not have any specific training for the specialty. Those countries are Luxembourg, Belgium, Denmark, Greece, Sweden, Poland, Cyprus, Ireland and the UK. On the contrary, training is organised in the Czech Republic, Germany, Romania, Spain, Lithuania, Finland, Austria, the Slovak Republic and Lithuania but could last from 1 week to 12 yrs. Moreover, except for the UK and the …
- Published
- 2011
27. THE EUROPEAN SLEEP APNOEA DATABASE (ESADA) -- Report from 22 European Sleep Laboratories
- Author
-
Jan Hedner, A. Vitols, M. Pretl, Pawel Sliwinski, Ingo Fietze, John-Arthur Kvamme, Daniel Rodenstein, Ruzena Tkacova, Juan F. Masa, Marisa Bonsignore, Thomas Penzel, Ludger Grote, Ferran Barbé, J.M. Montserrat, Renata L. Riha, Rainer Schulz, Jan Zieliński, Walter Mcnicholas Mcnicholas, W DeBacker, Pierre Escourrou, Tarja Saaresranta, Marrone O, H. Vrints, Peretz Lavie, Giedrius Varoneckas, Carolina Lombardi, Gianfranco Parati, Hedner, J, Grote, L, Bonsignore, MR, McNicholas, W, Lavie, P, Parati, G, Sliwinski, P, Barbé, F, Escourrou, P, Fietze, I, Masa, JF, Kvamme, JA, Lombardi, C, Marrone, O, Montserrat, JM, Penzel, T, Pretl, M, Riha, R, Rodenstein, D, Saaresranta, T, Schulz, R, Tkacova, R, Varoneckas, G, Vitols, A, Vrints, H, Zielinski, J, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (SLuc) Service de pneumologie, Bonsignore, M, Mcnicholas, W, Masa, J, Kvamme, J, Montserrat, J, and Debacker, W
- Subjects
Pulmonary and Respiratory Medicine ,Adult ,Male ,Pediatrics ,medicine.medical_specialty ,Adolescent ,Databases, Factual ,Cross-sectional study ,Polysomnography ,Comorbidity ,Cohort Studies ,Sleep Apnea Syndromes ,Risk Factors ,Surveys and Questionnaires ,medicine ,Humans ,Medical history ,Respiratory system ,Aged ,Sleep disorder ,medicine.diagnostic_test ,Anthropometry ,Models, Genetic ,business.industry ,comorbidity, European Sleep Apnoea Database, genetic, multicentre cohort, obstructive sleep apnoea syndrome ,Cardiorespiratory fitness ,MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE ,Middle Aged ,medicine.disease ,respiratory tract diseases ,Obesity, Morbid ,Europe ,Cohort ,Female ,Human medicine ,business - Abstract
The European Sleep Apnoea Database (ESADA) reflects a network of 22 sleep disorder centres in Europe enabled by a COST action B26 programme. This ongoing project aims to describe differences in standard clinical care of patients with obstructive sleep apnoea (OSA) and to establish a resource for genetic research in this disorder. Patients with suspected OSA are consecutively included and followed up according to local clinical standards. Anthropometrics, medical history, medication, daytime symptoms and sleep data (polysomnography or cardiorespiratory polygraphy) are recorded in a structured web-based report form. 5,103 patients (1,426 females, mean±SD age 51.8±12.6 yrs, 79.4% with apnoea/hypopnoea index (AHI) ≥5 events·h -1) were included from March 15, 2007 to August 1, 2009. Morbid obesity (body mass index ≥35 kg·m -2) was present in 21.1% of males and 28.6% of females. Cardiovascular, metabolic and pulmonary comorbidities were frequent (49.1%, 32.9% and 14.2%, respectively). Patients investigated with a polygraphic method had a lower AHI than those undergoing polysomnography (23.2±23.5 versus 29.1±26.3 events·h -1, p
- Published
- 2011
28. The effects of benralizumab on airway geometry and dynamics in severe eosinophilic asthma: a single-arm study design exploring a functional respiratory imaging approach.
- Author
-
Genofre E, Carstens D, DeBacker W, Muchmore P, Panettieri RA Jr, Rhodes K, Shih VH, and Trudo F
- Subjects
- Humans, Prospective Studies, Antibodies, Monoclonal, Humanized pharmacology, Antibodies, Monoclonal, Humanized therapeutic use, Inflammation, Asthma diagnostic imaging, Asthma drug therapy, Pulmonary Eosinophilia diagnostic imaging, Pulmonary Eosinophilia drug therapy
- Abstract
Background: Severe eosinophilic asthma (SEA) is characterised by elevated blood/sputum eosinophil counts and airway inflammation, which can lead to mucus plug-mediated airway obstruction, increased exacerbation frequency, declines in lung function, and death. Benralizumab targets the alpha-subunit of the interleukin-5 receptor found on eosinophils, leading to rapid and near complete eosinophil depletion. This is expected to result in reduced eosinophilic inflammation, reduced mucus plugging and improved airway patency and airflow distribution., Methods: BURAN is an interventional, single-arm, open-label, uncontrolled, prospective, multicentre study during which participants will receive three 30 mg subcutaneous doses of benralizumab at 4-week intervals. This study will use functional respiratory imaging (FRI), a novel, quantitative method of assessing patients' lung structure and function based on detailed, three-dimensional models of the airways, with direct comparison of images taken at Weeks 0 and 13. Patients aged ≥ 18 years with established SEA who may be receiving oral corticosteroids and/or other asthma controller medications, who are inadequately controlled on inhaled corticosteroid-long-acting β
2 -agonist therapies and who have had ≥ 2 asthma exacerbations in the previous 12 months will be included. The objectives of BURAN are to describe changes in airway geometry and dynamics, measured by specific image-based airway volume and other FRI endpoints, following benralizumab therapy. Outcomes will be evaluated using descriptive statistics. Changes in FRI parameters, mucus plugging scores and central/peripheral ratio will be quantified as mean percent change from baseline (Week 0) to Week 13 (± 5 days) and statistical significance will be evaluated using paired t-tests. Relationships between FRI parameters/mucus plugging scores and conventional lung function measurements at baseline will be assessed with linear regression analyses for associations between outcomes, scatterplots to visualise the relationship, and correlation coefficients (Spearman's rank and Pearson's) to quantify the strength of these associations., Conclusions: The BURAN study will represent one of the first applications of FRI-a novel, non-invasive, highly sensitive method of assessing lung structure, function and health-in the field of biologic respiratory therapies. Findings from this study will increase understanding of cellular-level eosinophil depletion mechanisms and improvements in lung function and asthma control following benralizumab treatment. Trial registration EudraCT: 2022-000152-11 and NCT05552508., (© 2023. The Author(s).)- Published
- 2023
- Full Text
- View/download PDF
29. Lung Deposition of Inhaled Extrafine Beclomethasone Dipropionate/Formoterol Fumarate/Glycopyrronium Bromide in Healthy Volunteers and Asthma: The STORM Study.
- Author
-
Usmani OS, Baldi S, Warren S, Panni I, Girardello L, Rony F, Taylor G, DeBacker W, and Georges G
- Subjects
- Administration, Inhalation, Drug Combinations, Formoterol Fumarate, Glycopyrrolate adverse effects, Healthy Volunteers, Humans, Lung diagnostic imaging, Treatment Outcome, Asthma diagnostic imaging, Asthma drug therapy, Beclomethasone adverse effects
- Abstract
Background: An extrafine formulation triple therapy combination of beclomethasone dipropionate (BDP), formoterol fumarate (FF), and glycopyrronium bromide (GB) has been developed for the maintenance treatment of asthma and chronic obstructive pulmonary disease. This study used gamma scintigraphy to evaluate the intrapulmonary and extrapulmonary in vivo deposition of BDP/FF/GB, and the intrapulmonary regional distribution of the deposited formulation. Methods: This open-label uncontrolled nonrandomized single-dose study recruited 10 healthy volunteers and 9 patients with asthma. After a krypton-81m (
81m Kr) ventilation scan was conducted, subjects inhaled study drug (four inhalations of BDP/FF/GB 100/6/12.5 μg radiolabeled using technetium-99 m [99m Tc]) through pressurized metered-dose inhaler, and a series of scintigraphic images were taken. The primary objective was to evaluate intrapulmonary drug deposition of BDP/FF/GB, determined as the percentage of nominal (i.e., metered) dose. Secondary endpoints included central/peripheral deposition ratio (C/P), and the standardized central/peripheral ratio (sC/P;99m Tc aerosol C/P/81m Kr gas C/P). Results: All participants completed the study, with all scintigraphy procedures performed at one site. In patients with asthma, mean ± standard deviation intrapulmonary deposition was 25.50% ± 6.81%, not significantly different to that in healthy volunteers (22.74% ± 9.19%; p = 0.4715). Approximately half of the lung dose was deposited in the peripheral region of the lung (fraction deposited 0.52 ± 0.07 and 0.49 ± 0.06 in healthy volunteers and patients with asthma, respectively), resulting in C/P ratios of 0.94 ± 0.25 and 1.06 ± 0.25, respectively, with sC/P ratios of 1.80 ± 0.40 and 1.94 ± 0.38. Deposition patterns were similar in the two populations. BDP/FF/GB was well tolerated. Conclusions: This study confirmed that the extrafine particles delivered by BDP/FF/GB penetrate the peripheral areas of the lungs, with a similar proportion of particles deposited in the central and peripheral regions. Importantly, the deposition patterns were similar in healthy volunteers and patients with asthma, suggesting that disease characteristics are unlikely to impact drug deposition. Clinical Trial Registration number: NCT03795350.- Published
- 2022
- Full Text
- View/download PDF
30. Anatomic predictors of response and mechanism of action of upper airway stimulation therapy in patients with obstructive sleep apnea.
- Author
-
Schwab RJ, Wang SH, Verbraecken J, Vanderveken OM, Van de Heyning P, Vos WG, DeBacker JW, Keenan BT, Ni Q, and DeBacker W
- Subjects
- Female, Humans, Hyoid Bone physiopathology, Male, Mandible physiopathology, Middle Aged, Movement, Palate, Soft physiopathology, Polysomnography, Sleep Apnea, Obstructive diagnostic imaging, Sleep Apnea, Obstructive pathology, Tomography, X-Ray Computed, Tongue physiopathology, Treatment Outcome, Electric Stimulation Therapy, Hypoglossal Nerve physiology, Respiratory System anatomy & histology, Respiratory System physiopathology, Sleep Apnea, Obstructive physiopathology, Sleep Apnea, Obstructive therapy
- Abstract
Study Objectives: Upper airway stimulation has been shown to be an effective treatment for some patients with obstructive sleep apnea. However, the mechanism by which hypoglossal nerve stimulation increases upper airway caliber is not clear. Therefore, the objective of this study was to identify the mechanism of action of upper airway stimulation. We hypothesized that, with upper airway stimulation, responders would show greater airway opening in the retroglossal (base of the tongue) region, greater hyoid movement toward the mandible, and greater anterior motion in the posterior, inferior region of the tongue compared with nonresponders., Methods: Seven participants with obstructive sleep apnea who had been successfully treated with upper airway stimulation (responders) and six participants who were not successfully treated (nonresponders) underwent computed tomography imaging during wakefulness with and without hypoglossal nerve stimulation. Responders reduced their apnea-hypopnea index (AHI) by 22.63 ± 6.54 events per hour, whereas nonresponders had no change in their AHI (0.17 ± 14.04 events per hour). We examined differences in upper airway caliber, the volume of the upper airway soft tissue structures, craniofacial relationships, and centroid tongue and soft palate movement between responders and nonresponders with and without hypoglossal nerve stimulation., Results: Our data indicate that compared with nonresponders, responders had a smaller baseline soft palate volume and, with stimulation, had (1) a greater increase in retroglossal airway size; (2) increased shortening of the mandible-hyoid distance; and (3) greater anterior displacement of the tongue., Conclusions: These results suggest that smaller soft palate volumes at baseline and greater tongue movement anteriorly with stimulation improve the response to upper airway stimulation.
- Published
- 2018
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.