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1. Management of radiation-induced oral mucositis in head and neck cancer patients: a real-life survey among 25 Italian radiation oncology centers

Author

Bergamaschi, Luca, Vincini, Maria Giulia, Zaffaroni, Mattia, Pepa, Matteo, Angelicone, Ilaria, Astone, Antonio, Bergamini, Cristiana, Buonopane, Sergio, Conte, Mario, De Rosa, Nicola, Deantoni, Chiara, Dell’Oca, Italo, Di Gennaro, Davide, Di Muzio, Nadia, Osti, Mattia Falchetto, Federico, Manuela, Ferini, Gianluca, Franzese, Ciro, Gatti, Marco, Grillo, Antonietta, Iorio, Vincenzo, Manzo, Roberto, Marmiroli, Luca, Martin, Giuseppe, Mazzuca, Federica, Molinaro, Maria Angela, Muto, Matteo, Pacelli, Roberto, Pepe, Alfonsina, Perillo, Annarita, Russo, Donatella, Salerno, Francesca, Spadaro, Pietro, Viola, Anna, Iorio, Giuseppe Carlo, Muto, Paolo, Ricardi, Umberto, and Alterio, Daniela

Published
2024
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8. Toxicity of Hypofractionated Whole Breast Radiotherapy Without Boost and Timescale of Late Skin Responses in a Large Cohort of Early-Stage Breast Cancer Patients

Author

Fodor, Andrei, Brombin, Chiara, Mangili, Paola, Tummineri, Roberta, Pasetti, Marcella, Zerbetto, Flavia, Longobardi, Barbara, Galvan, Ariadna Sanchez, Deantoni, Chiara Lucrezia, Dell'Oca, Italo, Castriconi, Roberta, Esposito, Pier Giorgio, Deli, Aniko Maria, Rancoita, Paola Maria Vittoria, Fiorino, Claudio, Vecchio, Antonella Del, Di Serio, Mariaclelia Stefania, and Di Muzio, Nadia Gisella

Published
2022
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9. The impact of nutritional intervention on quality of life and outcomes in patients with head and neck cancers undergoing chemoradiation.

Author

Cardellini, Sara, Deantoni, Chiara Lucrezia, Paccagnella, Matteo, Casirati, Amanda, Pontara, Andrea, Marinosci, Alessandro, Tresoldi, Moreno, Giordano, Leone, Chiara, Anna, Dell'Oca, Italo, Di Muzio, Nadia Gisella, Caccialanza, Riccardo, and Mirabile, Aurora

Subjects
BODY composition, NUTRITION counseling, WEIGHT loss, PROGRESSION-free survival, DIETARY supplements, HEAD & neck cancer
Abstract

Introduction: Chemoradiotherapy in head and neck cancer patients has a curative intent but often deteriorates nutritional status leading to sarcopenia and cachexia. Methods: In this observational and single-centered study, a prospective evaluation of several biochemical and anthropometrical parameters, weight loss, handgrip strength, visual analogue scale of appetite, questionnaires associated with malnutrition & quality of life and body composition (obtained by Bioelectrical Impedance Vector Analysis) was performed before and after high-dose cisplatin chemotherapy combined with radiotherapy in 60 patients affected by head and neck cancer. Oral nutritional supplements were used to reach the correct number of daily calories and proteins. Results and discussion: All patients completed radiotherapy as planned and the 96,4% of them did not interrupt chemotherapy for toxicity, reaching a total dose of at least 200mg/m2. Despite a rapid deterioration of body composition during treatment, nutritional support helped patients to maintain (or in some cases improve) anthropometric parameters from the end of chemoradiotherapy to the following 3 months. Low prealbumin and albumin pre-treatment led to higher risk of toxicities with consequent reduction of cisplatin dose intensity, whereas weight at the end of the treatment seems to be an interesting predicting factor for disease free and overall survival (p=0.007; p=0.015). [ABSTRACT FROM AUTHOR]

Published
2024
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11. Impact of molecular subtype on 1325 early-stage breast cancer patients homogeneously treated with hypofractionated radiotherapy without boost: Should the indications for radiotherapy be more personalized?

Author

Fodor, Andrei, Brombin, Chiara, Mangili, Paola, Borroni, Fulvio, Pasetti, Marcella, Tummineri, Roberta, Zerbetto, Flavia, Longobardi, Barbara, Perna, Lucia, Dell’Oca, Italo, Deantoni, Chiara L., Deli, Aniko M., Chiara, Anna, Broggi, Sara, Castriconi, Roberta, Esposito, Pier Giorgio, Slim, Najla, Passoni, Paolo, Baroni, Simone, Villa, Stefano L., Rancoita, Paola M.V., Fiorino, Claudio, Del Vecchio, Antonella, Bianchini, Giampaolo, Gentilini, Oreste D., Di Serio, Mariaclelia S., and Di Muzio, N.G.

Published
2021
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13. Abiraterone and Ionizing Radiation Alter the Sphingolipid Homeostasis in Prostate Cancer Cells

Author

Murdica, Valentina, Mancini, Giulia, Loberto, Nicoletta, Bassi, Rosaria, Giussani, Paola, Di Muzio, Nadia, Deantoni, Chiara, Prinetti, Alessandro, Aureli, Massimo, Sonnino, Sandro, COHEN, IRUN R., Series Editor, LAJTHA, ABEL, Series Editor, LAMBRIS, JOHN D., Series Editor, PAOLETTI, RODOLFO, Series Editor, Rezaei, Nima, Series Editor, Chattopadhyay, Kausik, editor, and Basu, Subhash C., editor

Published
2018
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15. 2516: NTCP model of acute toxicity after whole breast irradiation: training and extended validation

Author

Cicchetti, Alessandro, Vincenzi, Monica, Castriconi, Roberta, Mangili, Paola, Fodor, Andrei, Gabellini, Maria Giulia Ubeira, Chiara, Anna, Deantoni, Chiara, Midulla, Martina, Mori, Martina, Pasetti, Marcella, Palazzo, Gabriele, Tummineri, Roberta, Torrisi, Miriam, Rancati, Tiziana, Vecchio, Antonella del, Di Muzio, Nadia G, and Fiorino, Claudio

Published
2024
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19. Impact of low skeletal muscle mass in oropharyngeal cancer patients treated with radical chemo-radiotherapy: A mono-institutional experience

Author

Deantoni, Chiara L., Mirabile, Aurora, Chiara, Anna, Giannini, Laura, Midulla, Martina, Del Vecchio, Antonella, Fiorino, Claudio, Fodor, Andrei, Di Muzio, Nadia G., and Dell’Oca, Italo

Abstract

Aims: Low skeletal muscle mass index (SMI) has recently emerged as an independent prognostic factor in oncological patients and it is linked with poor survival and higher treatment toxicity. The present study aims to determine the possible impact of low SMI on survival and acute toxicity in oropharyngeal patients.Methods: Seventy-six patients with locally advanced oropharyngeal squamous cell carcinoma (stage III-IVC) were treated in our institution with Helical TomoTherapy® (HT - Accuray, Maddison, WI, USA) between 2005 and 2021. All patients received concomitant platinum-based chemotherapy (CT) (at least 200 mg/m2). The SMI was determined using the calculation of cross-sectional area at C3. Twenty patients (26%) presented pre-treatment low SMI, according to Chargi definitions.Results: All patients concluded the treatment. Thirteen patients with low SMI (65%) and 22 patients with normal SMI (39%) presented acute toxicity greater than or equal to grade 3, but this difference was not statistically significant (p-value = 0.25). Overall survival was analyzed in 65 patients, excluding those who finished CT-RT less than six months before the analysis. Overall survival was significantly lower in low SMI versus normal SMI patients (p-value = 0.035). Same difference was observed in N0-N2a patients, suggesting an important role of SMI also in lower nodal burden and putatively better prognosis.Conclusions: Although the results are limited to a small population, our case series has the advantage to be very homogeneous in patients and treatment characteristics. In our setting, SMI demonstrated a crucial impact on overall survival. Further investigation with larger samples is necessary to confirm our results to improve patient outcomes.

Published
2024
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22. CT radiomic predictors of local relapse after SBRT for lung oligometastases from colorectal cancer: a single institute pilot study

Author

Fodor, Andrei, primary, Mori, Martina, additional, Tummineri, Roberta, additional, Broggi, Sara, additional, Deantoni, Chiara Lucrezia, additional, Mangili, Paola, additional, Baroni, Simone, additional, Villa, Stefano Lorenzo, additional, Dell’Oca, Italo, additional, Del Vecchio, Antonella, additional, Fiorino, Claudio, additional, and Di Muzio, Nadia, additional

Published
2022
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23. Pros-IT CNR: an Italian prostate cancer monitoring project

Author

Noale, Marianna, Maggi, Stefania, Artibani, Walter, Bassi, Pier Francesco, Bertoni, Filippo, Bracarda, Sergio, Conti, Giario Natale, Corvò, Renzo, Gacci, Mauro, Graziotti, Pierpaolo, Magrini, Stefano Maria, Maurizi Enrici, Riccardo, Mirone, Vincenzo, Montironi, Rodolfo, Muto, Giovanni, Pecoraro, Stefano, Porreca, Angelo, Ricardi, Umberto, Tubaro, Andrea, Zagonel, Vittorina, Zattoni, Filiberto, Crepaldi, Gaetano, Crepaldi, Gaetano, Maggi, Stefania, Noale, Marianna, Porreca, Angelo, Artibani, Walter, Bassi, Pier Francesco, Bracarda, Sergio, Conti, Giario Natale, Corvò, Renzo, Graziotti, Pierpaolo, Maurizi Enrici, Riccardo, Mirone, Vincenzo, Montironi, Rodolfo, Bertoni, Filippo, Gacci, Mauro, Magrini, Stefano Maria, Muto, Giovanni, Pecoraro, Stefano, Ricardi, Umberto, Tubaro, Andrea, Zagonel, Vittorina, Zattoni, Filiberto, Alitto, Anna Rita, Ambrosi, Enrica, Antonelli, Alessandro, Aristei, Cynthia, Barbieri, Michele, Bardari, Franco, Bardoscia, Lilia, Barra, Salvina, Bartoncini, Sara, Basso, Umberto, Becherini, Carlotta, Bellavita, Rita, Bergamaschi, Franco, Berlingheri, Stefania, Berruti, Alfredo, Borghesi, Marco, Bortolus, Roberto, Borzillo, Valentina, Bosetti, Davide, Bove, Giuseppe, Bove, Pierluigi, Brausi, Maurizio, Bruni, Alessio, Bruno, Giorgio, Brunocilla, Eugenio, Buffoli, Alberto, Buglione, Michela, Buttigliero, Consuelo, Cacciamani, Giovanni, Caldiroli, Michela, Cardo, Giuseppe, Carmignani, Giorgio, Carrieri, Giuseppe, Castelli, Emanuele, Castrezzati, Elisabetta, Catalano, Gianpiero, Cattarino, Susanna, Catucci, Francesco, Cavallini Francolini, Dario, Ceccarini, Ofelia, Celia, Antonio, Chiancone, Francesco, Chini, Tommaso, Cianci, Claudia, Cisternino, Antonio, Collura, Devis, Corbella, Franco, Corinti, Matteo, Corsi, Paolo, Cortese, Fiorenza, Corti, Luigi, de Nunzio, Cosimo, Cristiano, Olga, D’Angelillo, Rolando, Da Pozzo, Luigi, D’agostino, Daniele, D’Andrea, David, Dandrea, Matteo, De Angelis, Michele, De Cobelli, Ottavio, De Concilio, Bernardino, De Lisa, Antonello, De Luca, Stefano, De Stefani, Agostina, Deantoni, Chiara Lucrezia, Degli Esposti, Claudio, Destito, Anna, Detti, Beatrice, Di Muzio, Nadia, Di Stasio, Andrea, Di Stefano, Calogero, Di Trapani, Danilo, Difino, Giuseppe, Falivene, Sara, Farullo, Giuseppe, Fedelini, Paolo, Ferrari, Ilaria, Ferrau, Francesco, Ferro, Matteo, Fodor, Andrei, Fontana, Francesco, Francesca, Francesco, Giulio, Francolini, Frata, Paolo, Frezza, Giovanni, Gabriele, Pietro, Galeandro, Maria, Garibaldi, Elisabetta, Gennari, Pietro, Gentilucci, Alessandro, Giacobbe, Alessandro, Giussani, Laura, Giusti, Giuseppe, Gontero, Paolo, Guarneri, Alessia, Guida, Cesare, Gurioli, Alberto, Huqi, Dorijan, Imbimbo, Ciro, Ingrosso, Gianluca, Iotti, Cinzia, Italia, Corrado, La Mattina, Pierdaniele, Lamanna, Enza, Lastrucci, Luciana, Lazzari, Grazia, Liberale, Fabiola, Liguori, Giovanni, Lisi, Roberto, Lohr, Frank, Lombardo, Riccardo, Lovisolo, Jon, Ludovico, Giuseppe Mario, Macchione, Nicola, Maggio, Francesca, Malizia, Michele, Manasse, Gianluca, Mandoliti, Giovanni, Mantini, Giovanna, Marafioti, Luigi, Marciello, Luisa, Marconi, Alberto Mario, Martillotta, Antonietta, Marzano, Salvino, Masciullo, Stefano, Maso, Gloria, Massenzo, Adele, Mazzeo, Ercole, Mearini, Luigi, Medoro, Serena, Molè, Rosa, Monesi, Giorgio, Montanari, Emanuele, Montefiore, Franco, Montesi, Giampaolo, Morgia, Giuseppe, Moro, Gregorio, Muscas, Giorgio, Musio, Daniela, Muto, Paolo, Muzzonigro, Giovanni, Napodano, Giorgio, Negro, Carlo Luigi Augusto, Nidini, Mattia, Ntreta, Maria, Orsatti, Marco, Palazzolo, Carmela, Palumbo, Isabella, Parisi, Alessandro, Parma, Paolo, Pavan, Nicola, Pericolini, Martina, Pinto, Francesco, Pistone, Antonio, Pizzuti, Valerio, Platania, Angelo, Polli, Caterina, Pomara, Giorgio, Ponti, Elisabetta, Porcaro, Antonio Benito, Porpiglia, Francesco, Pugliese, Dario, Pycha, Armin, Raguso, Giuseppe, Rampini, Andrea, Randone, Donato Franco, Roscigno, Marco, Ruggieri, Maria Paola, Ruoppo, Giuseppe, Sanseverino, Roberto, Santacaterina, Anna, Santarsieri, Michele, Santoni, Riccardo, Scagliarini, Sarah, Scagliotti, Giorgio Vittorio, Scanzi, Mauro, Scarcia, Marcello, Schiavina, Riccardo, Sciarra, Alessandro, Sciorio, Carmine, Scolaro, Tindaro, Scuzzarella, Salvatore, Selvaggio, Oscar, Serao, Armando, Serni, Sergio, Signor, Marco Andrea, Silvani, Mauro, Silvano, Giovanni, Silvestris, Franco, Simeone, Claudio, Simone, Valeria, Spagnoletti, Girolamo, Spinelli, Matteo Giulio, Squillace, Luigi, Tombolini, Vincenzo, Toninelli, Mariastella, Triggiani, Luca, Trinchieri, Alberto, Trodella, Luca Eolo, Trodella, Lucio, Trombetta, Carlo, Tronnolone, Lidia, Tucci, Marcello, Urzì, Daniele, Valdagni, Riccardo, Valeriani, Maurizio, Vanoli, Maurizio, Vitali, Elisabetta, Zaramella, Stefano, Zeccolini, Guglielmo, Zini, Giampaolo, and the Pros-IT CNR study group

Published
2017
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24. Accurate prediction of long-term risk of biochemical failure after salvage radiotherapy including the impact of pelvic node irradiation

Author

Cozzarini, Cesare, primary, Olivieri, Michela, additional, Magli, Alessandro, additional, Cante, Domenico, additional, Noris Chiorda, Barbara, additional, Munoz, Fernando, additional, Faiella, Adriana, additional, Olivetta, Elisa, additional, Deantoni, Chiara, additional, Fodor, Andrei, additional, Signor, Marco Andrea, additional, Petrucci, Edoardo, additional, Avuzzi, Barbara, additional, Ferella, Letizia, additional, Pastorino, Alice, additional, Garibaldi, Elisabetta, additional, Gatti, Marco, additional, Rago, Luciana, additional, Statuto, Teodora, additional, Rancati, Tiziana, additional, Briganti, Alberto, additional, Montorsi, Francesco, additional, Valdagni, Riccardo, additional, Sanguineti, Giuseppe, additional, Di Muzio, Nadia Gisella, additional, and Fiorino, Claudio, additional

Published
2022
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25. External validation of an 18F-FDG-PET radiomic model predicting survival after radiotherapy for oropharyngeal cancer.

Author

Mori, Martina, Deantoni, Chiara, Olivieri, Michela, Spezi, Emiliano, Chiara, Anna, Baroni, Simone, Picchio, Maria, Del Vecchio, Antonella, Di Muzio, Nadia Gisella, Fiorino, Claudio, and Dell'Oca, Italo

Subjects
*OROPHARYNGEAL cancer, *POSITRON emission tomography computed tomography, *RADIOTHERAPY, *CHEMORADIOTHERAPY, *CANCER patients
Abstract

Purpose/objective: The purpose of the study is to externally validate published 18F-FDG-PET radiomic models for outcome prediction in patients with oropharyngeal cancer treated with chemoradiotherapy. Material/methods: Outcome data and pre-radiotherapy PET images of 100 oropharyngeal cancer patients (stage IV:78) treated with concomitant chemotherapy to 66–69 Gy/30 fr were available. Tumors were segmented using a previously validated semi-automatic method; 450 radiomic features (RF) were extracted according to IBSI (Image Biomarker Standardization Initiative) guidelines. Only one model for cancer-specific survival (CSS) prediction was suitable to be independently tested, according to our criteria. This model, in addition to HPV status, SUVmean and SUVmax, included two independent meta-factors (Fi), resulting from combining selected RF clusters. In a subgroup of 66 patients with complete HPV information, the global risk score R was computed considering the original coefficients and was tested by Cox regression as predictive of CSS. Independently, only the radiomic risk score RF derived from Fi was tested on the same subgroup to learn about the radiomics contribution to the model. The metabolic tumor volume (MTV) was also tested as a single predictor and its prediction performances were compared to the global and radiomic models. Finally, the validation of MTV and the radiomic score RF were also tested on the entire dataset. Results: Regarding the analysis of the subgroup with HPV information, with a median follow-up of 41.6 months, seven patients died due to cancer. R was confirmed to be associated to CSS (p value = 0.05) with a C-index equal 0.75 (95% CI=0.62–0.85). The best cut-off value (equal to 0.15) showed high ability in patient stratification (p=0.01, HR=7.4, 95% CI=1.6–11.4). The 5-year CSS for R were 97% (95% CI: 93–100%) vs 74% (56–92%) for low- and high-risk groups, respectively. RF and MTV alone were also significantly associated to CSS for the subgroup with an almost identical C-index. According to best cut-off value (RF>0.12 and MTV>15.5cc), the 5-year CSS were 96% (95% CI: 89–100%) vs 65% (36–94%) and 97% (95% CI: 88–100%) vs 77% (58–93%) for RF and MTV, respectively. Results regarding RF and MTV were confirmed in the overall group. Conclusion: A previously published PET radiomic model for CSS prediction was independently validated. Performances of the model were similar to the ones of using only the MTV, without improvement of prediction accuracy. [ABSTRACT FROM AUTHOR]

Published
2023
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26. Patient-specific forecasting of post-radiotherapy prostate-specific antigen kinetics enables early prediction of biochemical relapse

Author

Lorenzo, Guillermo, primary, Muzio, Nadia di, additional, Deantoni, Chiara Lucrezia, additional, Cozzarini, Cesare, additional, Fodor, Andrei, additional, Briganti, Alberto, additional, Montorsi, Francesco, additional, Pérez-García, Víctor M., additional, Gomez, Hector, additional, and Reali, Alessandro, additional

Published
2022
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33. Ten Year Results of Extensive Nodal Radiotherapy and Moderately Hypofractionated Simultaneous Integrated Boost in Unfavorable Intermediate-, High-, and Very High-Risk Prostate Cancer

Author

Di Muzio, Nadia Gisella, primary, Deantoni, Chiara Lucrezia, additional, Brombin, Chiara, additional, Fiorino, Claudio, additional, Cozzarini, Cesare, additional, Zerbetto, Flavia, additional, Mangili, Paola, additional, Tummineri, Roberta, additional, Dell’Oca, Italo, additional, Broggi, Sara, additional, Pasetti, Marcella, additional, Chiara, Anna, additional, Rancoita, Paola Maria Vittoria, additional, Del Vecchio, Antonella, additional, Di Serio, Mariaclelia Stefania, additional, and Fodor, Andrei, additional

Published
2021
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34. Replacing Manual Planning of Whole Breast Irradiation With Knowledge-Based Automatic Optimization by Virtual Tangential-Fields Arc Therapy

Author

Castriconi, Roberta, primary, Esposito, Pier Giorgio, additional, Tudda, Alessia, additional, Mangili, Paola, additional, Broggi, Sara, additional, Fodor, Andrei, additional, Deantoni, Chiara L., additional, Longobardi, Barbara, additional, Pasetti, Marcella, additional, Perna, Lucia, additional, del Vecchio, Antonella, additional, Di Muzio, Nadia Gisella, additional, and Fiorino, Claudio, additional

Published
2021
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35. P-62 Helical Intensity Modulated Radiotherapy 18 FDG PET guided in locally advanced oropharyngeal cancer: a mono-institutional experience

Author

Deantoni, Chiara Lucrezia, primary, Chiara, Anna, additional, Mirabile, Aurora, additional, Giordano, Leone, additional, Bondi, Stefano, additional, Broggi, Sara, additional, Baroni, Simone, additional, Fodor, Andrei, additional, Zerbetto, Flavia, additional, Tummineri, Roberta, additional, Gregorc, Vanesa, additional, Picchio, Maria, additional, Fiorino, Claudio, additional, Oca, Italo Dell, additional, and Muzio, Nadia Gisella Di, additional

Published
2021
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36. Toxicity of Hypofractionated Whole Breast Radiotherapy Without Boost in a Large “Real-Life” Cohort of Consecutive Early-Stage Breast Cancer Patients

Author

Fodor, Andrei, primary, Brombin, Chiara, additional, Mangili, Paola, additional, Tummineri, Roberta, additional, Pasetti, Marcella, additional, Zerbetto, Flavia, additional, Longobardi, Barbara, additional, Galvan, Ariadna Sanchez, additional, Deantoni, Chiara L., additional, Dell'Oca, Italo, additional, Rancoita, Paola M.V., additional, Fiorino, Claudio, additional, Vecchio, Antonella Del, additional, Serio, Mariaclelia S. Di, additional, and Muzio, N.G. Di, additional

Published
2021
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37. Dose–volume effects for pelvic bone marrow in predicting hematological toxicity in prostate cancer radiotherapy with pelvic node irradiation

Author

Sini Carla, Fiorino Claudio, Perna Lucia, Chiorda Barbara Noris, Deantoni Chiara Lucrezia, Bianchi Marco, Sacco Vincenzo, Briganti Alberto, MONTORSI , FRANCESCO, Calandrino Riccardo, Di Muzio Nadia, Cozzarini Cesare, DI MUZIO, NADIA GISELLA, Sini, Carla, Fiorino, Claudio, Perna, Lucia, Chiorda Barbara, Nori, Deantoni Chiara, Lucrezia, Bianchi, Marco, Sacco, Vincenzo, Briganti, Alberto, Montorsi, Francesco, Calandrino, Riccardo, Di Muzio, Nadia, Cozzarini, Cesare, and DI MUZIO, NADIA GISELLA

Subjects
Male, Oncology, Radiology, Nuclear Medicine and Imaging, medicine.medical_treatment, Hematologic toxicity, 030218 nuclear medicine & medical imaging, Prostate cancer, 0302 clinical medicine, Bone Marrow, Prospective Studies, Radiation Injurie, Radiotherapy Dosage, Chemoradiotherapy, Hematology, Middle Aged, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Adjuvant, Human, medicine.medical_specialty, Intensity-modulated radiotherapy, Whole-Pelvis, Tomotherapy, 03 medical and health sciences, Pelvic Bone, Lymphopenia, Internal medicine, medicine, Humans, Radiology, Nuclear Medicine and imaging, Risk factor, Pelvic Bones, Radiation Injuries, Radiometry, Aged, Salvage Therapy, Lymphatic Irradiation, business.industry, Prostatic Neoplasms, Hematologic Disease, medicine.disease, Hematologic Diseases, Radiation therapy, Prospective Studie, Prostatic Neoplasm, Radiotherapy, Adjuvant, Radiotherapy, Intensity-Modulated, Bone marrow, Radiotherapy, Conformal, business, Lumbosacral joint
Abstract

Purpose To prospectively identify clinical/dosimetric predictors of acute/late hematologic toxicity (HT) in chemo-naÏve patients treated with whole-pelvis radiotherapy (WPRT) for prostate cancer. Material and methods Data of 121 patients treated with adjuvant/salvage WPRT were analyzed (static-field IMRT n = 19; VMAT/Rapidarc n = 57; Tomotherapy n = 45). Pelvic bone marrow (BM) was delineated as ilium (IL), lumbosacral, lower and whole pelvis (WP), and the relative DVHs were calculated. HT was graded both according to CTCAE v4.03 and as variation in percentage relative to baseline. Logistic regression was used to analyze association between HT and clinical/DVHs factors. Results Significant differences (p < 0.005) in the DVH of BM volumes between different techniques were found: Tomotherapy was associated with larger volumes receiving low doses (3-20 Gy) and smaller receiving 40-50 Gy. Lower baseline absolute values of WBC, neutrophils and lymphocytes (ALC) predicted acute/late HT (p ≤ 0.001). Higher BM V40 was associated with higher risk of acute Grade3 (OR = 1.018) or late Grade2 lymphopenia (OR = 1.005). Two models predicting lymphopenia were developed, both including baseline ALC, and BM WP-V40 (AUC = 0.73) and IL-V40+smoking (AUC = 0.904) for acute/late respectively. Conclusions Specific regions of pelvic BM predicting acute/late lymphopenia, a risk factor for viral infections, were identified. The 2-variable models including specific constraints to BM may help reduce HT.

Published
2016

38. 822 Local radiotherapy synergizes with tumor-specific TCR redirected T cells in the rejection of prostate cancer

Author

Catucci, Marco, primary, Basso, Veronica, additional, Deantoni, Chiara Lucrezia, additional, Baroni, Simone, additional, Spinelli, Antonello, additional, Freschi, Massimo, additional, Cozzarini, Cesare, additional, Fiorino, Claudio, additional, Muzio, Nadia Di, additional, Formenti, Silvia, additional, Demaria, Sandra, additional, and Mondino, Anna, additional

Published
2020
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40. Metastasis-directed Therapy in Treating Nodal Oligorecurrent Prostate Cancer: A Multi-institutional Analysis Comparing the Outcome and Toxicity of Stereotactic Body Radiotherapy and Elective Nodal Radiotherapy

Author

De Bleser, Elise, primary, Jereczek-Fossa, Barbara Alicja, additional, Pasquier, David, additional, Zilli, Thomas, additional, Van As, Nicholas, additional, Siva, Shankar, additional, Fodor, Andrei, additional, Dirix, Piet, additional, Gomez-Iturriaga, Alfonso, additional, Trippa, Fabio, additional, Detti, Beatrice, additional, Ingrosso, Gianluca, additional, Triggiani, Luca, additional, Bruni, Alessio, additional, Alongi, Filippo, additional, Reynders, Dries, additional, De Meerleer, Gert, additional, Surgo, Alessia, additional, Loukili, Kaoutar, additional, Miralbell, Raymond, additional, Silva, Pedro, additional, Chander, Sarat, additional, Di Muzio, Nadia Gisella, additional, Maranzano, Ernesto, additional, Francolini, Giulio, additional, Lancia, Andrea, additional, Tree, Alison, additional, Deantoni, Chiara Lucrezia, additional, Ponti, Elisabetta, additional, Marvaso, Giulia, additional, Goetghebeur, Els, additional, and Ost, Piet, additional

Published
2019
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41. Pros-IT CNR: an Italian prostate cancer monitoring project

Author

Bassi, Pierfrancesco, Maggi, Ilaria Stefania, Artibani, Walter, Bassi, Pier Francesco, Bertoni, Filippo, Bracarda, Sergio, Conti, Giario Natale, Corvò, Renzo, Gacci, Mauro, Graziotti, Pierpaolo, Magrini, Stefano Maria, Maurizi Enrici, Riccardo, Mirone, Vincenzo, Montironi, Rodolfo, Muto, Giovanni, Pecoraro, Stefano, Porreca, Angelo, Ricardi, Umberto, Tubaro, Andrea, Zagonel, Vittorina, Zattoni, Filiberto, Crepaldi, Gaetano, Noale, Marianna, Alitto, Anna Rita, Ambrosi, Enrica, Antonelli, Alessandro, Aristei, Cynthia, Barbieri, Michele, Bardari, Franco, Bardoscia, Lilia, Barra, Salvina, Bartoncini, Sara, Basso, Umberto, Becherini, Carlotta, Bellavita, Rita, Bergamaschi, Franco, Berlingheri, Stefania, Berruti, Alfredo, Borghesi, Marco, Bortolus, Roberto, Borzillo, Valentina, Bosetti, Davide, Bove, Giuseppe, Bove, Pierluigi, Brausi, Maurizio, Bruni, Alessio, Baldari, Giorgio Bruno Cristiano, Brunocilla, Eugenio, Buffoli, Alberto, Buglione, Michela, Buttigliero, Consuelo, Cacciamani, Giovanni, Caldiroli, Michela, Cardo, Giuseppe, Carmignani, Giorgio, Carrieri, Giuseppe, Castelli, Emanuele, Castrezzati, Elisabetta, Catalano, Gianpiero, Cattarino, Susanna, Catucci, Francesco, Cavallini Francolini, Dario, Ceccarini, Ofelia, Celia, Antonio, Chiancone, Francesco, Chini, Tommaso, Cianci, Claudia, Cisternino, Antonio, Collura, Devi, Corbella, Franco, Corinti, Matteo, Corsi, Paolo, Cortese, Fiorenza, Corti, Luigi, de Nunzio, Cosimo, Cristiano, Olga, D'Angelillo, Rolando Maria, Da Pozzo, Luigi, D'Agostino, Daniele, D’Andrea, David, Dandrea, Matteo, De Angelis, Michele, De Cobelli, Ottavio, De Concilio, Bernardino, De Lisa, Antonello, De Luca, Stefano, De Stefani, Agostina, Deantoni, Chiara Lucrezia, Degli Esposti, Claudio, Destito, Anna, Detti, Beatrice, Di Muzio, Nadia, Di Stasio, Andrea, Di Stefano, Calogero, Di Trapani, Danilo, Difino, Giuseppe, Falivene, Sara, Farullo, Giuseppe, Fedelini, Paolo, Ferrari, Ilaria, Ferrau, Francesco, Ferro, Matteo, Fodor, Andrei, Fontana, Francesco, Francesca, Francesco, Giulio, Francolini, Frata, Paolo, Frezza, Giovanni, Gabriele, Pietro, Galeandro, Maria, Garibaldi, Ida Marina Elisabetta, Gennari, Pietro, Gentilucci, Alessandro, Giacobbe, Alessandro, Giussani, Laura, Giusti, Giuseppe, Gontero, Paolo, Guarneri, Alessia, Guida, Cesare, Gurioli, Alberto, Huqi, Dorijan, Imbimbo, Ciro, Ingrosso, Gianluca, Iotti, Cinzia, Italia, Corrado, La Mattina, Pierdaniele, Lamanna, Enza, Lastrucci, Luciana, Lazzari, Grazia, Liberale, Fabiola, Liguori, Giovanni, Lisi, Roberto, Lohr, Frank, Lombardo, Riccardo, Lovisolo, Jon, Ludovico, Giuseppe Mario, Macchione, Nicola, Maggio, Francesca, Malizia, Michele, Manasse, Gianluca, Mandoliti, Giovanni, Mantini, Giovanna, Marafioti, Luigi, Marciello, Luisa, Marconi, Alberto Mario, Martillotta, Antonietta, Marzano, Salvino, Masciullo, Stefano, Maso, Gloria, Massenzo, Adele, Mazzeo, Ercole, Mearini, Luigi, Medoro, Serena, Molè, Rosa, Monesi, Giorgio, Montanari, Emanuele, Montefiore, Franco, Montesi, Giampaolo, Morgia, Giuseppe, Moro, Gregorio, Muscas, Giorgio, Musio, Daniela, Muto, Paolo, Muzzonigro, Giovanni, Napodano, Giorgio, Negro, Carlo Luigi Augusto, Nidini, Mattia, Ntreta, Maria, Orsatti, Marco, Palazzolo, Carmela, Palumbo, Isabella, Parisi, Alessandro, Parma, Paolo, Pavan, Nicola, Pericolini, Martina, Pinto, Francesco, Pistone, Antonio, Pizzuti, Valerio, Platania, Angelo, Polli, Caterina, Pomara, Giorgio, Ponti, Elisabetta, Porcaro, Antonio Benito, Porpiglia, Francesco, Pugliese, Dario, Pycha, Armin, Raguso, Giuseppe, Rampini, Andrea, Randone, Donato Franco, Roscigno, Marco, Ruggieri, Maria Paola, Ruoppo, Giuseppe, Sanseverino, Roberto, Santacaterina, Anna, Santarsieri, Michele, Santoni, Riccardo, Scagliarini, Sarah, Scagliotti, Giorgio Vittorio, Scanzi, Mauro, Scarcia, Marcello, Schiavina, Riccardo, Sciarra, Alessandro, Sciorio, Carmine, Scolaro, Tindaro, Scuzzarella, Salvatore, Selvaggio, Oscar, Serao, Armando, Serni, Sergio, Signor, Marco Andrea, Silvani, Mauro, Silvano, Giovanni, Silvestris, Franco, Simeone, Claudio, Simone, Valeria, Spagnoletti, Girolamo, Spinelli, Matteo Giulio, Squillace, Luigi, Tombolini, Vincenzo, Toninelli, Mariastella, Triggiani, Luca, Trinchieri, Alberto, Trodella, Luca Eolo, Trodella, Lucio, Trombetta, Carlo, Tronnolone, Lidia, Tucci, Marcello, Urzì, Daniele, Valdagni, Riccardo, Valeriani, Maurizio, Vanoli, Maurizio, Vitali, Elisabetta, Zaramella, Stefano, Zeccolini, Guglielmo, Zini, Giampaolo, Noale, Marianna (ORCID:0000-0002-4313-8427), Maggi, Stefania, D’Angelillo, Rolando, D’agostino, Daniele, Mantini, Giovanna (ORCID:0000-0001-5303-4499), Bassi, Pierfrancesco, Maggi, Ilaria Stefania, Artibani, Walter, Bassi, Pier Francesco, Bertoni, Filippo, Bracarda, Sergio, Conti, Giario Natale, Corvò, Renzo, Gacci, Mauro, Graziotti, Pierpaolo, Magrini, Stefano Maria, Maurizi Enrici, Riccardo, Mirone, Vincenzo, Montironi, Rodolfo, Muto, Giovanni, Pecoraro, Stefano, Porreca, Angelo, Ricardi, Umberto, Tubaro, Andrea, Zagonel, Vittorina, Zattoni, Filiberto, Crepaldi, Gaetano, Noale, Marianna, Alitto, Anna Rita, Ambrosi, Enrica, Antonelli, Alessandro, Aristei, Cynthia, Barbieri, Michele, Bardari, Franco, Bardoscia, Lilia, Barra, Salvina, Bartoncini, Sara, Basso, Umberto, Becherini, Carlotta, Bellavita, Rita, Bergamaschi, Franco, Berlingheri, Stefania, Berruti, Alfredo, Borghesi, Marco, Bortolus, Roberto, Borzillo, Valentina, Bosetti, Davide, Bove, Giuseppe, Bove, Pierluigi, Brausi, Maurizio, Bruni, Alessio, Baldari, Giorgio Bruno Cristiano, Brunocilla, Eugenio, Buffoli, Alberto, Buglione, Michela, Buttigliero, Consuelo, Cacciamani, Giovanni, Caldiroli, Michela, Cardo, Giuseppe, Carmignani, Giorgio, Carrieri, Giuseppe, Castelli, Emanuele, Castrezzati, Elisabetta, Catalano, Gianpiero, Cattarino, Susanna, Catucci, Francesco, Cavallini Francolini, Dario, Ceccarini, Ofelia, Celia, Antonio, Chiancone, Francesco, Chini, Tommaso, Cianci, Claudia, Cisternino, Antonio, Collura, Devi, Corbella, Franco, Corinti, Matteo, Corsi, Paolo, Cortese, Fiorenza, Corti, Luigi, de Nunzio, Cosimo, Cristiano, Olga, D'Angelillo, Rolando Maria, Da Pozzo, Luigi, D'Agostino, Daniele, D’Andrea, David, Dandrea, Matteo, De Angelis, Michele, De Cobelli, Ottavio, De Concilio, Bernardino, De Lisa, Antonello, De Luca, Stefano, De Stefani, Agostina, Deantoni, Chiara Lucrezia, Degli Esposti, Claudio, Destito, Anna, Detti, Beatrice, Di Muzio, Nadia, Di Stasio, Andrea, Di Stefano, Calogero, Di Trapani, Danilo, Difino, Giuseppe, Falivene, Sara, Farullo, Giuseppe, Fedelini, Paolo, Ferrari, Ilaria, Ferrau, Francesco, Ferro, Matteo, Fodor, Andrei, Fontana, Francesco, Francesca, Francesco, Giulio, Francolini, Frata, Paolo, Frezza, Giovanni, Gabriele, Pietro, Galeandro, Maria, Garibaldi, Ida Marina Elisabetta, Gennari, Pietro, Gentilucci, Alessandro, Giacobbe, Alessandro, Giussani, Laura, Giusti, Giuseppe, Gontero, Paolo, Guarneri, Alessia, Guida, Cesare, Gurioli, Alberto, Huqi, Dorijan, Imbimbo, Ciro, Ingrosso, Gianluca, Iotti, Cinzia, Italia, Corrado, La Mattina, Pierdaniele, Lamanna, Enza, Lastrucci, Luciana, Lazzari, Grazia, Liberale, Fabiola, Liguori, Giovanni, Lisi, Roberto, Lohr, Frank, Lombardo, Riccardo, Lovisolo, Jon, Ludovico, Giuseppe Mario, Macchione, Nicola, Maggio, Francesca, Malizia, Michele, Manasse, Gianluca, Mandoliti, Giovanni, Mantini, Giovanna, Marafioti, Luigi, Marciello, Luisa, Marconi, Alberto Mario, Martillotta, Antonietta, Marzano, Salvino, Masciullo, Stefano, Maso, Gloria, Massenzo, Adele, Mazzeo, Ercole, Mearini, Luigi, Medoro, Serena, Molè, Rosa, Monesi, Giorgio, Montanari, Emanuele, Montefiore, Franco, Montesi, Giampaolo, Morgia, Giuseppe, Moro, Gregorio, Muscas, Giorgio, Musio, Daniela, Muto, Paolo, Muzzonigro, Giovanni, Napodano, Giorgio, Negro, Carlo Luigi Augusto, Nidini, Mattia, Ntreta, Maria, Orsatti, Marco, Palazzolo, Carmela, Palumbo, Isabella, Parisi, Alessandro, Parma, Paolo, Pavan, Nicola, Pericolini, Martina, Pinto, Francesco, Pistone, Antonio, Pizzuti, Valerio, Platania, Angelo, Polli, Caterina, Pomara, Giorgio, Ponti, Elisabetta, Porcaro, Antonio Benito, Porpiglia, Francesco, Pugliese, Dario, Pycha, Armin, Raguso, Giuseppe, Rampini, Andrea, Randone, Donato Franco, Roscigno, Marco, Ruggieri, Maria Paola, Ruoppo, Giuseppe, Sanseverino, Roberto, Santacaterina, Anna, Santarsieri, Michele, Santoni, Riccardo, Scagliarini, Sarah, Scagliotti, Giorgio Vittorio, Scanzi, Mauro, Scarcia, Marcello, Schiavina, Riccardo, Sciarra, Alessandro, Sciorio, Carmine, Scolaro, Tindaro, Scuzzarella, Salvatore, Selvaggio, Oscar, Serao, Armando, Serni, Sergio, Signor, Marco Andrea, Silvani, Mauro, Silvano, Giovanni, Silvestris, Franco, Simeone, Claudio, Simone, Valeria, Spagnoletti, Girolamo, Spinelli, Matteo Giulio, Squillace, Luigi, Tombolini, Vincenzo, Toninelli, Mariastella, Triggiani, Luca, Trinchieri, Alberto, Trodella, Luca Eolo, Trodella, Lucio, Trombetta, Carlo, Tronnolone, Lidia, Tucci, Marcello, Urzì, Daniele, Valdagni, Riccardo, Valeriani, Maurizio, Vanoli, Maurizio, Vitali, Elisabetta, Zaramella, Stefano, Zeccolini, Guglielmo, Zini, Giampaolo, Noale, Marianna (ORCID:0000-0002-4313-8427), Maggi, Stefania, D’Angelillo, Rolando, D’agostino, Daniele, and Mantini, Giovanna (ORCID:0000-0001-5303-4499)

Abstract

Aims: The Pros-IT CNR project aims to monitor a sample of Italian males ≥18 years of age who have been diagnosed in the participating centers with incident prostate cancer, by analyzing their clinical features, treatment protocols and outcome results in relation to quality of life. Methods: Pros-IT CNR is an observational, prospective, multicenter study. The National Research Council (CNR), Neuroscience Institute, Aging Branch (Padua) is the promoting center. Ninety-seven Italian centers located throughout Italy were involved. The field study began in September 1, 2014. Subjects eligible were diagnosed with biopsy-verified prostate cancer, naà ̄ve. A sample size of 1500 patients was contemplated. A baseline assessment including anamnestic data, clinical history, risk factors, the initial diagnosis, cancer staging information and quality of life (Italian UCLA Prostate Cancer Index; SF-12 Scale) was completed. Six months after the initial diagnosis, a second assessment evaluating the patient’s health status, the treatment carried out, and the quality of life will be made. A third assessment, evaluating the treatment follow-up and the quality of life, will be made 12 months after the initial diagnosis. The 4th, 5th, 6th and 7th assessments, similar to the third, will be completed 24, 36, 48 and 60 months after the initial diagnosis, respectively, and will include also a Food Frequency Questionnaire and the Physical Activity Scale for the Elderly. Discussion: The study will provide information on patients’ quality of life and its variations over time in relation to the treatments received for the prostate cancer.

Published
2017

43. 11C-Choline PET/CT based Helical Tomotherapy as Treatment Approach for Bone Metastases in Recurrent Prostate Cancer Patients

Author

Incerti, Elena, primary, Gangemi, Vincenzo, additional, Mapelli, Paola, additional, Deantoni, Chiara Lucrezia, additional, Giovacchini, Giampiero, additional, Fallanca, Federico, additional, Fodor, Andrei, additional, Ciarmiello, Andrea, additional, Baldari, Sergio, additional, Gianolli, Luigi, additional, Di Muzio, Nadia, additional, and Picchio, Maria, additional

Published
2017
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44. MP84-13 A NEW APPROACH FOR AN IMPROVED PSA DOUBLING TIME COMPUTATION FOR SELECTING PATIENTS CANDIDATE TO TIMELY SALVAGE RADIOTHERAPY FOR A BIOCHEMICAL RECURRENCE AFTER PROSTATECTOMY

Author

Rancoita, Paola Maria, primary, Cozzarini, Cesare, additional, Noris Chiorda, Barbara, additional, Briganti, Alberto, additional, Deantoni, Chiara Lucrezia, additional, Fiorino, Claudio, additional, Fossati, Nicola, additional, Pasetti, Marcella, additional, Sini, Carla, additional, Montorsi, Francesco, additional, Di Muzio, Nadia, additional, and Di Serio, Clelia, additional

Published
2016
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45. MP14-15 CLINICO-DOSIMETRIC FACTORS PREDICTING LONG-TERM SEVERE URINARY INCONTINENCE AFTER POST-PROSTATECTOMY RT. RESULTS OF A LONGITUDINAL OBSERVATIONAL STUDY.

Author

Noris Chiorda, Barbara, primary, Sini, Carla, additional, Fiorino, Claudio, additional, Briganti, Alberto, additional, Chiara, Anna, additional, Deantoni, Chiara Lucrezia, additional, Fossati, Nicola, additional, Gandaglia, Giorgio, additional, Suardi, Nazareno, additional, Montorsi, Francesco, additional, Di Muzio, Nadia, additional, and Cozzarini, Cesare, additional

Published
2016
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46. MP14-10 DETRIMENTAL ROLE OF PRE-PROSTATECTOMY NEOADJUVANT ANDROGEN DEPRIVATION IN NODE-NEGATIVE PATIENTS TREATED WITH ADJUVANT RT

Author

Cozzarini, Cesare, primary, Noris Chiorda, Barbara, additional, Deantoni, Chiara Lucrezia, additional, Briganti, Alberto, additional, Fiorino, Claudio, additional, Gandaglia, Giorgio, additional, Fossati, Nicola, additional, Freschi, Massimo, additional, Sini, Carla, additional, Montironi, Rodolfo, additional, Montorsi, Francesco, additional, and Di Muzio, Nadia, additional

Published
2016
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47. Un caso di carcinoma mammario maschile in stadio avanzato

Author

Cerica, Alessandra, D'Alba, Rossella, Baio, Ambrogia, Cavallini Francolini, Dario, Colombo, Sara, De Vecchi, Pietro, Squillace, Luigi, Cammarano, Flora, Deantoni, Chiara Lucrezia, Iacovelli, Nicola Alessandro, Noris Chiorda, Barbara, Plasmati, Cinzia, Massaro, Patrizia, and Corbella, Franco

Abstract

Il carcinoma della mammella maschile è un tumore raro, rappresentando meno dell’1% di tutte le neoplasie mammarie, tuttavia la sua incidenza è in aumento. Sebbene la storia naturale e i fattori prognostici non differiscano dalle forme femminili, questa neoplasia si caratterizza per una maggiore mortalità in quanto i sintomi di esordio vengono spesso sottovalutati giungendo così alla diagnosi quando la malattia è già in fase avanzata. Presentiamo il caso di un uomo di 53 anni affetto da carcinoma duttale infiltrante della mammella sinistra, curato con mastectomia radicale, chemioterapia, radioterapia ed ormonoterapia adiuvanti. L’intervallo di tempo libero da malattia è stato di 21 mesi; si è avuta successivamente progressione di malattia locoregionale e a distanza (comparsa di metastasi cutanee della parete toracica, ossee e pleuriche). Il paziente è deceduto a distanza di 56 mesi dalla diagnosi., Bollettino della Società Medico Chirurgica di Pavia, Vol 125, N° 4 (2012)

Published
2013
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48. Chemioradioterapia nel carcinoma del pancreas localmente avanzato

Author

Corbella, Franco, Brugnatelli, Silvia, Cerica, Alessandra, D'Alba, Rossella, Baio, Ambrogia, Cavallini Francolini, Dario, Colombo, Sara, De Vecchi, Pietro, Squillace, Luigi, Cammarano, Flora, Deantoni, Chiara Lucrezia, Iacovelli, Nicola Alessandro, Massaro, Patrizia, Noris Chiorda, Barbara, and Plasmati, Cinzia

Abstract

Il carcinoma del pancreas è il secondo tumore più frequente del tratto gastrointestinale ed è associato ad una prognosi infausta in quanto viene generalmente diagnosticato in stadio già avanzato. La chemioradioterapia è in grado di influire sulla sopravvivenza prolungando l’intervallo di tempo libero da malattia e migliorando la resecabilità del tumore. Questo studio si è posto lo scopo di dimostrare l’efficacia e la tollerabilità della chemioterapia con Gemcitabina, seguita da radioterapia associata a somministrazione bisettimanale di basse dosi di Gemcitabina in pazienti affetti da adenocarcinoma del pancreas localmente avanzato, non metastatico. Sono stati curati 20 pazienti con diagnosi istologica di carcinoma pancreatico. Il follow-up medio è stato di 10 mesi (range 1-27); dopo la conclusione dello schema terapeutico 4 pazienti hanno raggiunto una stabilità locale di malattia, 7 pazienti sono andati incontro a progressione locale, e in 9 pazienti sono comparse metastasi a distanza. I disturbi maggiormente riscontrati durante il trattamento sono stati nausea e anoressia; il 25% dei pazienti non ha lamentato alcun effetto collaterale., Bollettino della Società Medico Chirurgica di Pavia, Vol 125, N° 4 (2012)

Published
2013
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49. La radioterapia adiuvante nella cura del timoma

Author

D'Alba, Rossella, Cerica, Alessandra, Baio, Ambrogia, Colombo, Sara, Cavallini Francolini, Dario, De Vecchi, Pietro, Squillace, Luigi, Deantoni, Chiara Lucrezia, Cammarano, Flora, Plasmati, Cinzia, Massaro, Patrizia, Noris Chiorda, Barbara, Iacovelli, Nicola Alessandro, and Corbella, Franco

Abstract

Il timoma è un tumore raro tuttavia nella popolazione adulta rappresenta la neoplasia più comune del mediastino. La terapia del timoma prevede un approccio multidisciplinare ben definito per gli stadi iniziali, mentre la gestione dei pazienti in stadio avanzato è ancora controversa. Dal novembre 2002 al marzo 2010, 9 pazienti affetti da timoma sono stati curati con radioterapia adiuvante postoperatoria presso la SC di Radioterapia Oncologica della Fondazione IRCCS Policlinico San Matteo di Pavia. Tutti i pazienti sono stati curati con radioterapia conformazionale tridimensionale (3DCRT) sul mediastino, con una dose totale media di 52.6 Gy (range 50-56), frazionamento convenzionale (1.8-2 Gy/die per 5 giorni la settimana). Gli effetti collaterali acuti registrati sono stati: dermatite in 6 pazienti e disfagia in 8 pazienti. A circa due mesi dal termine della terapia tutti i pazienti presentavano risoluzione di tali effetti. Al dicembre 2011 con un follow-up medio di 50.1 mesi (range 16-102), mediana 37 mesi, tutti i pazienti risultavano liberi da malattia; 5 presentavano ancora sintomi relativi alla miastenia gravis. A distanza di tempo dalla radioterapia tutti i pazienti presentavano fibrosi polmonare di grado I nel volume irradiato, clinicamente non significativa ma rilevabile alla diagnostica per immagine (TC)., Bollettino della Società Medico Chirurgica di Pavia, Vol 125, N° 1 (2012)

Published
2012
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50. Radioterapia post-operatoria in pazienti con neoplasia localmente avanzata del distretto cervico-cefalico sottoposti a chirurgia demolitiva e ricostruzione con lembi: esperienza del gruppo oncologico testa-collo

Author

Colombo, Sara, Baio, Ambrogia, Cavallini Francolini, Dario, De Vecchi, Pietro, Squillace, Luigi, Deantoni, Chiara Lucrezia, Iacovelli, Nicola Alessandro, Benazzo, Marco, Bertino, Giulia, Occhini, Antonio, Porta, Camillo, Morbini, Patrizia, and Corbella, Franco

Abstract

Lo scopo di questo studio retrospettivo è stato quello di valutare l’efficacia e la tossicità acuta e tardiva dell’irradiazione post-operatoria in pazienti affetti da tumori del distretto cervico-cefalico localmente avanzati che erano stati sottoposti a chirurgia radicale e ricostruzione con lembi. Nel periodo tra gennaio 2003 e gennaio 2008, 27 pazienti sono stati sottoposti a radioterapia conformazionale tridimensionale. I pazienti maschi erano 23 e 4 erano femmine con un’età media di 60.6 anni (range 48-75 anni). Il tumore era localizzato al cavo orale in 12 pazienti (44.4%), nell’orofaringe in 2 pazienti (7.4%), nell’ipofaringe in 8 (29.6%) e nella laringe in 5 pazienti (18.5%). Tutti i tumori erano istologicamente carcinomi squamocellulari. Alla stadiazione si trattava di T1N2b=3.7%, T2N0=11.1%, T2N1=11.1%, T2N2a=7.4%, T2N2b=3.7%, T2N2c=7.4%, T3N1=7.4%, T3N2b=11.1%, T3N2c=7.4%, T4aN0=7.4%, T4aN1=3.7%, T4aN2a=3.7%, T4aN2b=7.4%, T4aN2c=7.4%. I lembi sono stati donati da: radio (25.9%), pettorale(18.5%), avambraccio (14.8%), digiuno (14.8%), fibula (11.1%) e platisma (3.7%). Tutti i pazienti sono stati curati sul letto chirurgico e sui linfonodi cervicali bilateralmente (PTVII: 50-54 Gy). In 17 casi abbiamo definito inoltre il PTVI (fino a 66 Gy) che corrisponde al letto chirurgico se i margini di resezione erano infiltrati o ai linfonodi nel caso di rottura capsulare. La dose è stata somministrata in frazioni da 2 Gy al giorno per 5 giorni alla settimana. Alla fine della terapia tutti i pazienti hanno ottenuto la remissione completa. Di questi il 74.1% ha mantenuto la remissione completa, dopo un follow-up medio di 25.9 mesi, il 18.5% ha mostrato una recidiva sulla sede del tumore primitivo, il 2.7% in sede linfonodale, e il 2.7% ha mostrato metastasi a distanza. Durante la terapia abbiamo registrato mucositi, dermatiti, disfagia, odinofagia, xerostomia, edema del sottocutaneo e trisma di grado I o II; reazioni di grado III si sono riscontrate solo in 3 casi. Tutti i pazienti hanno completato la terapia. Non è stata osservata alcuna tossicità tardiva rilevante durante il follow-up. Nessun paziente ha mostrato alterazioni o necrosi del lembo., Bollettino della Società Medico Chirurgica di Pavia, Vol 122, N° 3 (2009)

Published
2010
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