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Glioblastoma stem-like cells dynamically transition between a chemoradiation-resistant state and a chemoradiation-sensitive state. However, physical barriers in the tumour microenvironment restrict the delivery of chemotherapy to tumour compartments that are distant from blood vessels. Here, we show that a massively parallel computational model of the spatiotemporal dynamics of the perivascular niche that incorporates glioblastoma stem-like cells and differentiated tumour cells as well as relevant tissue-level phenomena can be used to optimize the administration schedules of concurrent radiation and temozolomide—the standard-of-care treatment for glioblastoma. In mice with platelet-derived growth factor (PDGF)-driven glioblastoma, the model-optimized treatment schedule increased the survival of the animals. For standard radiation fractionation in patients, the model predicts that chemotherapy may be optimally administered about one hour before radiation treatment. Computational models of the spatiotemporal dynamics of the tumour microenvironment could be used to predict tumour responses to a broader range of treatments and to optimize treatment regimens.

Harness the power of Unity 5 tools to write shaders and create stunning effects for next generation gamesAbout This BookLeverage the power of Unity 5 compatible shaders to create a variety of realistic surfacesCreate amazing visual effects for your Unity 5.x games by blending advanced post-processing techniques and lighting effectsAdd that extra visual edge to your games by learning pro level techniquesWho This Book Is ForThis book is for users who are familiar with creating Unity projects and are looking for the next step to create stunning high-end visuals in their game project using the latest tools and features. You are expected to understand the creation of basic Unity projects, game object types, and scene navigation. You will need some basic programming experience in C# or JavaScript.What You Will LearnBuild your own custom shaders to suit a variety of organic and inorganic surfacesCreate amazing visual effects using Unity 5's improved toolsetCompare the advantages of Metallic and Specular workflows in Unity's Physically Based Lighting SystemTake your Unity 5 project to the next level with advanced real-time and baked lighting methodsDesign powerful particle effectsFind out how shaders, materials, and scripts work together within the Unity frameworkDevelop high-end and optimized game visuals suitable for mobile devices and other platformsIn DetailWith the inclusion of Physically Based Shading and the Standard Shader, Unity has changed the game for independent and large scale developers alike. Never before has it been so easy to create startling high quality visuals in games and other interactive projects.This book will give you a solid understanding of the interaction of shaders, lighting and effects in Unity 5, and give you some great ideas for how you can maximize the visual impact of your own games for PC, mobile and other platforms. In the sequence of chapters you will find solutions to some of the major challenges to the creation of responsive and realis

A detailed guide to the complex new animation tools in Unity, packed with clear instructions and illustrated with original content in the context of a next generation zombie apocalypse adventure gameAbout This BookCreate and export models and animation sequences to Unity from 3ds max and MayaPrepare character models and animation for games using Mecanim's rigging toolsRetarget, adjust, and mix and match motion capture and other animation dataWrite and edit scripts compatible with Mecanim Animation ControllersWho This Book Is ForIf you are a Unity developer looking to get to grips with the character animation specific tools, a 3D software user who is new to Unity, or a beginner game developer who is interested in character animation and interaction, this book is ideal for you. Some experience with either the Unity interface or basic 3D coordinates is recommended, but not required.What You Will LearnLearn how to prepare a rigged character model to receive animation within UnityAcquire efficient techniques to refine and optimize motion capture dataRetarget animation sequences between different character rigsDiscover how to rig a humanoid character and export for use in UnityScript character interaction for a First Person character modelCreate dynamic animation sequences from scratch using keyframe techniques, in a variety of 3D software packagesLearn Project Management in UnityUnderstand how to set up a complex facial rig for speechSet up Animation Controllers with masked states and blend trees to create seamless and additive animation transitionsConstruct a ragdoll game object and instantiate it in a gameDevise Mecanim animation integration for the player and AI driven animation for enemy charactersIn DetailGame animation for independent developers has taken a giant leap forward with Unity 5's Mecanim toolset, which streamlines the import/export, retargeting, and many other aspects of the character animation workflow. Unity Character Animation with Mecanim is a great