Search

Your search keyword '"DeSantes, Kenneth"' showing total 169 results
Start Over Author "DeSantes, Kenneth"
169 results on '"DeSantes, Kenneth"'

1. Measuring the effect of newborn screening on survival after haematopoietic cell transplantation for severe combined immunodeficiency: a 36-year longitudinal study from the Primary Immune Deficiency Treatment Consortium.

Author

Thakar, Monica, Logan, Brent, Puck, Jennifer, Dunn, Elizabeth, Buckley, Rebecca, Cowan, Morton, OReilly, Richard, Kapoor, Neena, Satter, Lisa, Pai, Sung-Yun, Heimall, Jennifer, Chandra, Sharat, Ebens, Christen, Chellapandian, Deepak, Williams, Olatundun, Burroughs, Lauri, Saldana, Blachy, Rayes, Ahmad, Madden, Lisa, Chandrakasan, Shanmuganathan, Bednarski, Jeffrey, DeSantes, Kenneth, Cuvelier, Geoffrey, Teira, Pierre, Gillio, Alfred, Eissa, Hesham, Knutsen, Alan, Goldman, Frederick, Aquino, Victor, Shereck, Evan, Moore, Theodore, Caywood, Emi, Lugt, Mark, Rozmus, Jacob, Broglie, Larisa, Yu, Lolie, Shah, Ami, Andolina, Jeffrey, Liu, Xuerong, Parrott, Roberta, Dara, Jasmeen, Prockop, Susan, Martinez, Caridad, Kapadia, Malika, Jyonouchi, Soma, Sullivan, Kathleen, Bleesing, Jack, Chaudhury, Sonali, Petrovic, Aleksandra, Keller, Michael, Quigg, Troy, Parikh, Suhag, Shenoy, Shalini, Seroogy, Christine, Rubin, Tamar, Decaluwe, Hélène, Routes, John, Torgerson, Troy, Leiding, Jennifer, Pulsipher, Michael, Kohn, Donald, Griffith, Linda, Haddad, Elie, Dvorak, Christopher, and Notarangelo, Luigi

Subjects
Humans, Infant, Newborn, Graft vs Host Disease, Hematopoietic Stem Cell Transplantation, Longitudinal Studies, Neonatal Screening, Proportional Hazards Models, Severe Combined Immunodeficiency
Abstract

BACKGROUND: Severe combined immunodeficiency (SCID) is fatal unless durable adaptive immunity is established, most commonly through allogeneic haematopoietic cell transplantation (HCT). The Primary Immune Deficiency Treatment Consortium (PIDTC) explored factors affecting the survival of individuals with SCID over almost four decades, focusing on the effects of population-based newborn screening for SCID that was initiated in 2008 and expanded during 2010-18. METHODS: We analysed transplantation-related data from children with SCID treated at 34 PIDTC sites in the USA and Canada, using the calendar time intervals 1982-89, 1990-99, 2000-09, and 2010-18. Categorical variables were compared by χ2 test and continuous outcomes by the Kruskal-Wallis test. Overall survival was estimated by the Kaplan-Meier method. A multivariable analysis using Cox proportional hazards regression models examined risk factors for HCT outcomes, including the variables of time interval of HCT, infection status and age at HCT, trigger for diagnosis, SCID type and genotype, race and ethnicity of the patient, non-HLA-matched sibling donor type, graft type, GVHD prophylaxis, and conditioning intensity. FINDINGS: For 902 children with confirmed SCID, 5-year overall survival remained unchanged at 72%-73% for 28 years until 2010-18, when it increased to 87% (95% CI 82·1-90·6; n=268; p=0·0005). For children identified as having SCID by newborn screening since 2010, 5-year overall survival was 92·5% (95% CI 85·8-96·1), better than that of children identified by clinical illness or family history in the same interval (79·9% [69·5-87·0] and 85·4% [71·8-92·8], respectively [p=0·043]). Multivariable analysis demonstrated that the factors of active infection (hazard ratio [HR] 2·41, 95% CI 1·56-3·72; p

Published
2023

2. The diagnosis of severe combined immunodeficiency: Implementation of the PIDTC 2022 Definitions.

Author

Pai, Sung-Yun, Kapoor, Neena, Satter, Lisa, Buckley, Rebecca, OReilly, Richard, Chandra, Sharat, Bednarski, Jeffrey, Williams, Olatundun, Rayes, Ahmad, Moore, Theodore, Ebens, Christen, Davila Saldana, Blachy, Petrovic, Aleksandra, Chellapandian, Deepak, Cuvelier, Geoffrey, Vander Lugt, Mark, Caywood, Emi, Chandrakasan, Shanmuganathan, Eissa, Hesham, Goldman, Frederick, Shereck, Evan, Aquino, Victor, Desantes, Kenneth, Madden, Lisa, Miller, Holly, Yu, Lolie, Broglie, Larisa, Gillio, Alfred, Shah, Ami, Knutsen, Alan, Andolina, Jeffrey, Joshi, Avni, Szabolcs, Paul, Kapadia, Malika, Martinez, Caridad, Parrot, Roberta, Sullivan, Kathleen, Prockop, Susan, Abraham, Roshini, Thakar, Monica, Leiding, Jennifer, Haddad, Elie, Heimall, Jennifer, Dunn, Elizabeth, Pulsipher, Michael, Griffith, Linda, Notarangelo, Luigi, Dvorak, Christopher, Puck, Jennifer, Cowan, Morton, and Kohn, Donald

Subjects
Omenn syndrome, SCID, Severe combined immunodeficiency, leaky/atypical SCID, newborn screening, typical SCID, Infant, Newborn, Humans, Infant, Severe Combined Immunodeficiency, Retrospective Studies, Prospective Studies, Homeodomain Proteins
Abstract

BACKGROUND: Shearer et al in 2014 articulated well-defined criteria for the diagnosis and classification of severe combined immunodeficiency (SCID) as part of the Primary Immune Deficiency Treatment Consortiums (PIDTCs) prospective and retrospective studies of SCID. OBJECTIVE: Because of the advent of newborn screening for SCID and expanded availability of genetic sequencing, revision of the PIDTC 2014 Criteria was needed. METHODS: We developed and tested updated PIDTC 2022 SCID Definitions by analyzing 379 patients proposed for prospective enrollment into Protocol 6901, focusing on the ability to distinguish patients with various SCID subtypes. RESULTS: According to PIDTC 2022 Definitions, 18 of 353 patients eligible per 2014 Criteria were considered not to have SCID, whereas 11 of 26 patients ineligible per 2014 Criteria were determined to have SCID. Of note, very low numbers of autologous T cells (

Published
2023

3. Relevance of lymphocyte proliferation to PHA in severe combined immunodeficiency (SCID) and T cell lymphopenia

Author

Abraham, Roshini S., Basu, Amrita, Heimall, Jennifer R., Dunn, Elizabeth, Yip, Alison, Kapadia, Malika, Kapoor, Neena, Satter, Lisa Forbes, Buckley, Rebecca, O'Reilly, Richard, Cuvelier, Geoffrey D.E., Chandra, Sharat, Bednarski, Jeffrey, Chaudhury, Sonali, Moore, Theodore B., Haines, Hilary, Dávila Saldaña, Blachy J., Chellapandian, Deepakbabu, Rayes, Ahmad, Chen, Karin, Caywood, Emi, Chandrakasan, Shanmuganathan, Lugt, Mark Thomas Vander, Ebens, Christen, Teira, Pierre, Shereck, Evan, Miller, Holly, Aquino, Victor, Eissa, Hesham, Yu, Lolie C., Gillio, Alfred, Madden, Lisa, Knutsen, Alan, Shah, Ami J., DeSantes, Kenneth, Barnum, Jessie, Broglie, Larisa, Joshi, Avni Y., Kleiner, Gary, Dara, Jasmeen, Prockop, Susan, Martinez, Caridad, Mousallem, Talal, Oved, Joseph, Burroughs, Lauri, Marsh, Rebecca, Torgerson, Troy R., Leiding, Jennifer W., Pai, Sung Yun, Kohn, Donald B., Pulsipher, Michael A., Griffith, Linda M., Notarangelo, Luigi D., Cowan, Morton J., Puck, Jennifer, Dvorak, Christopher C., and Haddad, Elie

Published
2024
Full Text
View/download PDF

4. Posttransplantation late complications increase over time for patients with SCID: A Primary Immune Deficiency Treatment Consortium (PIDTC) landmark study

Author

Eissa, Hesham, Thakar, Monica S., Shah, Ami J., Logan, Brent R., Griffith, Linda M., Dong, Huaying, Parrott, Roberta E., O’Reilly, Richard J., Dara, Jasmeen, Kapoor, Neena, Forbes Satter, Lisa, Chandra, Sharat, Kapadia, Malika, Chandrakasan, Shanmuganathan, Knutsen, Alan, Jyonouchi, Soma C., Molinari, Lyndsay, Rayes, Ahmad, Ebens, Christen L., Teira, Pierre, Dávila Saldaña, Blachy J., Burroughs, Lauri M., Chaudhury, Sonali, Chellapandian, Deepak, Gillio, Alfred P., Goldman, Fredrick, Malech, Harry L., DeSantes, Kenneth, Cuvelier, Geoff D.E., Rozmus, Jacob, Quinones, Ralph, Yu, Lolie C., Broglie, Larisa, Aquino, Victor, Shereck, Evan, Moore, Theodore B., Vander Lugt, Mark T., Mousallem, Talal I., Oved, Joeseph H., Dorsey, Morna, Abdel-Azim, Hisham, Martinez, Caridad, Bleesing, Jacob H., Prockop, Susan, Kohn, Donald B., Bednarski, Jeffrey J., Leiding, Jennifer, Marsh, Rebecca A., Torgerson, Troy, Notarangelo, Luigi D., Pai, Sung-Yun, Pulsipher, Michael A., Puck, Jennifer M., Dvorak, Christopher C., Haddad, Elie, Buckley, Rebecca H., Cowan, Morton J., and Heimall, Jennifer

Published
2024
Full Text
View/download PDF

5. Genotype, oxidase status, and preceding infection or autoinflammation do not affect allogeneic HCT outcomes for CGD

Author

Leiding, Jennifer W., Arnold, Danielle E., Parikh, Suhag, Logan, Brent, Marsh, Rebecca A., Griffith, Linda M., Wu, Ruizhe, Kidd, Sharon, Mallhi, Kanwaldeep, Chellapandian, Deepak, Si Lim, Stephanie J., Grunebaum, Eyal, Falcone, E. Liana, Murguia-Favela, Luis, Grossman, Debbi, Prasad, Vinod K., Heimall, Jennifer R., Touzot, Fabien, Burroughs, Lauri M., Bleesing, Jack, Kapoor, Neena, Dara, Jasmeen, Williams, Olatundun, Kapadia, Malika, Oshrine, Benjamin R., Bednarski, Jeffrey J., Rayes, Ahmad, Chong, Hey, Cuvelier, Geoffrey D. E., Forbes Satter, Lisa R., Martinez, Caridad, Vander Lugt, Mark T., Yu, Lolie C., Chandrakasan, Shanmuganathan, Joshi, Avni, Prockop, Susan E., Dávila Saldaña, Blachy J., Aquino, Victor, Broglie, Larisa A., Ebens, Christen L., Madden, Lisa M., DeSantes, Kenneth, Milner, Jordan, Rangarajan, Hemalatha G., Shah, Ami J., Gillio, Alfred P., Knutsen, Alan P., Miller, Holly K., Moore, Theodore B., Graham, Pamela, Bauchat, Andrea, Bunin, Nancy J., Teira, Pierre, Petrovic, Aleksandra, Chandra, Sharat, Abdel-Azim, Hisham, Dorsey, Morna J., Birbrayer, Olga, Cowan, Morton J., Dvorak, Christopher C., Haddad, Elie, Kohn, Donald B., Notarangelo, Luigi D., Pai, Sung-Yun, Puck, Jennifer M., Pulsipher, Michael A., Torgerson, Troy R., Malech, Harry L., and Kang, Elizabeth M.

Published
2023
Full Text
View/download PDF

6. Infections in Infants with SCID: Isolation, Infection Screening, and Prophylaxis in PIDTC Centers.

Author

Dorsey, Morna J, Wright, Nicola AM, Chaimowitz, Natalia S, Dávila Saldaña, Blachy J, Miller, Holly, Keller, Michael D, Thakar, Monica S, Shah, Ami J, Abu-Arja, Rolla, Andolina, Jeffrey, Aquino, Victor, Barnum, JL, Bednarski, Jeffrey J, Bhatia, Monica, Bonilla, Francisco A, Butte, Manish J, Bunin, Nancy J, Chandra, Sharat, Chaudhury, Sonali, Chen, Karin, Chong, Hey, Cuvelier, Geoffrey DE, Dalal, Jignesh, DeFelice, Magee L, DeSantes, Kenneth B, Forbes, Lisa R, Gillio, Alfred, Goldman, Fred, Joshi, Avni Y, Kapoor, Neena, Knutsen, Alan P, Kobrynski, Lisa, Lieberman, Jay A, Leiding, Jennifer W, Oshrine, Benjamin, Patel, Kiran P, Prockop, Susan, Quigg, Troy C, Quinones, Ralph, Schultz, Kirk R, Seroogy, Christine, Shyr, David, Siegel, Subhadra, Smith, Angela R, Torgerson, Troy R, Vander Lugt, Mark T, Yu, Lolie C, Cowan, Morton J, Buckley, Rebecca H, Dvorak, Christopher C, Griffith, Linda M, Haddad, Elie, Kohn, Donald B, Logan, Brent, Notarangelo, Luigi D, Pai, Sung-Yun, Puck, Jennifer, Pulsipher, Michael A, and Heimall, Jennifer

Subjects
Humans, Severe Combined Immunodeficiency, Disease Susceptibility, Neonatal Screening, Prognosis, Antibiotic Prophylaxis, Hematopoietic Stem Cell Transplantation, Age of Onset, Infection Control, Infant, Infant, Newborn, Disease Management, Female, Male, Public Health Surveillance, Time-to-Treatment, Surveys and Questionnaires, Clinical Decision-Making, Infections, hematopoietic stem cell transplant, newborn screening, primary immunodeficiency, prophylaxis, severe combined immunodeficiency, Stem Cell Research, Perinatal Period - Conditions Originating in Perinatal Period, Pediatric, Prevention, Regenerative Medicine, Transplantation, Infant Mortality, Health Services, Clinical Research, Infection, Immunology
Abstract

PurposeThe Primary Immune Deficiency Treatment Consortium (PIDTC) enrolled children with severe combined immunodeficiency (SCID) in a prospective natural history study of hematopoietic stem cell transplant (HSCT) outcomes over the last decade. Despite newborn screening (NBS) for SCID, infections occurred prior to HSCT. This study's objectives were to define the types and timing of infection prior to HSCT in patients diagnosed via NBS or by family history (FH) and to understand the breadth of strategies employed at PIDTC centers for infection prevention.MethodsWe analyzed retrospective data on infections and pre-transplant management in patients with SCID diagnosed by NBS and/or FH and treated with HSCT between 2010 and 2014. PIDTC centers were surveyed in 2018 to understand their practices and protocols for pre-HSCT management.ResultsInfections were more common in patients diagnosed via NBS (55%) versus those diagnosed via FH (19%) (p = 0.012). Outpatient versus inpatient management did not impact infections (47% vs 35%, respectively; p = 0.423). There was no consensus among PIDTC survey respondents as to the best setting (inpatient vs outpatient) for pre-HSCT management. While isolation practices varied, immunoglobulin replacement and antimicrobial prophylaxis were more uniformly implemented.ConclusionInfants with SCID diagnosed due to FH had lower rates of infection and proceeded to HSCT more quickly than did those diagnosed via NBS. Pre-HSCT management practices were highly variable between centers, although uses of prophylaxis and immunoglobulin support were more consistent. This study demonstrates a critical need for development of evidence-based guidelines for the pre-HSCT management of infants with SCID following an abnormal NBS.Trial registrationNCT01186913.

Published
2021

7. Correction: Chronic Granulomatous Disease-Associated IBD Resolves and Does Not Adversely Impact Survival Following Allogeneic HCT.

Author

Marsh, Rebecca, Leiding, Jennifer, Logan, Brent, Griffith, Linda, Arnold, Danielle, Haddad, Elie, Falcone, E, Yin, Ziyan, Patel, Kadam, Arbuckle, Erin, Bleesing, Jack, Sullivan, Kathleen, Heimall, Jennifer, Burroughs, Lauri, Skoda-Smith, Suzanne, Chandrakasan, Shanmuganathan, Yu, Lolie, Oshrine, Benjamin, Cuvelier, Geoffrey, Thakar, Monica, Chen, Karin, Teira, Pierre, Shenoy, Shalini, Phelan, Rachel, Forbes, Lisa, Martinez, Caridad, Chellapandian, Deepak, Dávila Saldaña, Blachy, Shah, Ami, Weinacht, Katja, Joshi, Avni, Boulad, Farid, Quigg, Troy, Grossman, Debi, Torgerson, Troy, Graham, Pamela, Prasad, Vinod, Knutsen, Alan, Chong, Hey, Miller, Holly, de la Morena, M, DeSantes, Kenneth, Stenger, Elizabeth, Pai, Sung-Yun, Routes, John, Kapoor, Neena, Pulsipher, Michael, Malech, Harry, Parikh, Suhag, Kang, Elizabeth, Notarangelo, Luigi, Dvorak, Christopher, Puck, Jennifer, Cowan, Morton, and Kohn, Donald

Abstract

The original version of this article unfortunately contained the missing author, Caridad Martinez. The authors would like to correct the list. We apologize for any inconvenience that this may have caused. The correct author list is shown above.

Published
2020

8. The diagnosis of severe combined immunodeficiency: Implementation of the PIDTC 2022 Definitions

Author

Dvorak, Christopher C., Haddad, Elie, Heimall, Jennifer, Dunn, Elizabeth, Cowan, Morton J., Pai, Sung-Yun, Kapoor, Neena, Satter, Lisa Forbes, Buckley, Rebecca H., O’Reilly, Richard J., Chandra, Sharat, Bednarski, Jeffrey J., Williams, Olatundun, Rayes, Ahmad, Moore, Theodore B., Ebens, Christen L., Davila Saldana, Blachy J., Petrovic, Aleksandra, Chellapandian, Deepak, Cuvelier, Geoffrey D.E., Vander Lugt, Mark T., Caywood, Emi H., Chandrakasan, Shanmuganathan, Eissa, Hesham, Goldman, Frederick D., Shereck, Evan, Aquino, Victor M., Desantes, Kenneth B., Madden, Lisa M., Miller, Holly K., Yu, Lolie, Broglie, Larisa, Gillio, Alfred, Shah, Ami J., Knutsen, Alan P., Andolina, Jeffrey P., Joshi, Avni Y., Szabolcs, Paul, Kapadia, Malika, Martinez, Caridad A., Parrot, Roberta E., Sullivan, Kathleen E., Prockop, Susan E., Abraham, Roshini S., Thakar, Monica S., Leiding, Jennifer W., Kohn, Donald B., Pulsipher, Michael A., Griffith, Linda M., Notarangelo, Luigi D., and Puck, Jennifer M.

Published
2023
Full Text
View/download PDF

9. Chronic Granulomatous Disease-Associated IBD Resolves and Does Not Adversely Impact Survival Following Allogeneic HCT.

Author

Marsh, Rebecca A, Leiding, Jennifer W, Logan, Brent R, Griffith, Linda M, Arnold, Danielle E, Haddad, Elie, Falcone, E Liana, Yin, Ziyan, Patel, Kadam, Arbuckle, Erin, Bleesing, Jack J, Sullivan, Kathleen E, Heimall, Jennifer, Burroughs, Lauri M, Skoda-Smith, Suzanne, Chandrakasan, Shanmuganathan, Yu, Lolie C, Oshrine, Benjamin R, Cuvelier, Geoffrey DE, Thakar, Monica S, Chen, Karin, Teira, Pierre, Shenoy, Shalini, Phelan, Rachel, Forbes, Lisa R, Chellapandian, Deepak, Dávila Saldaña, Blachy J, Shah, Ami J, Weinacht, Katja G, Joshi, Avni, Boulad, Farid, Quigg, Troy C, Dvorak, Christopher C, Grossman, Debi, Torgerson, Troy, Graham, Pamela, Prasad, Vinod, Knutsen, Alan, Chong, Hey, Miller, Holly, de la Morena, M Teresa, DeSantes, Kenneth, Cowan, Morton J, Notarangelo, Luigi D, Kohn, Donald B, Stenger, Elizabeth, Pai, Sung-Yun, Routes, John M, Puck, Jennifer M, Kapoor, Neena, Pulsipher, Michael A, Malech, Harry L, Parikh, Suhag, Kang, Elizabeth M, and submitted on behalf of the Primary Immune Deficiency Treatment Consortium

Subjects
submitted on behalf of the Primary Immune Deficiency Treatment Consortium, Neutrophils, Transplantation Chimera, Humans, Inflammatory Bowel Diseases, Granulomatous Disease, Chronic, Graft vs Host Disease, Leukocyte Count, Prognosis, Treatment Outcome, Hematopoietic Stem Cell Transplantation, Transplantation, Homologous, Severity of Illness Index, Incidence, Retrospective Studies, Adolescent, Adult, Child, Child, Preschool, Infant, Female, Male, Young Adult, Allogeneic hematopoietic cell transplantation, allogeneic bone marrow transplantation, allogeneic hematopoietic stem cell transplantation, chronic granulomatous disease, inflammatory bowel disease, primary immunodeficiency, Autoimmune Disease, Inflammatory Bowel Disease, Digestive Diseases, Rare Diseases, Clinical Research, Transplantation, Oral and gastrointestinal, Immunology
Abstract

IntroductionInflammatory bowel disease (IBD) affects approximately 1/3 of patients with chronic granulomatous disease (CGD). Comprehensive investigation of the effect of allogeneic hematopoietic cell transplantation (HCT) on CGD IBD and the impact of IBD on transplant outcomes is lacking.MethodsWe collected data retrospectively from 145 patients with CGD who had received allogeneic HCT at 26 Primary Immune Deficiency Treatment Consortium (PIDTC) centers between January 1, 2005 and June 30, 2016.ResultsForty-nine CGD patients with IBD and 96 patients without IBD underwent allogeneic HCT. Eighty-nine percent of patients with IBD and 93% of patients without IBD engrafted (p = 0.476). Upper gastrointestinal acute GVHD occurred in 8.5% of patients with IBD and 3.5% of patients without IBD (p = 0.246). Lower gastrointestinal acute GVHD occurred in 10.6% of patients with IBD and 11.8% of patients without IBD (p = 0.845). The cumulative incidence of acute GVHD grades II-IV was 30% (CI 17-43%) in patients with IBD and 20% (CI 12-29%) in patients without IBD (p = 0.09). Five-year overall survival was equivalent for patients with and without IBD: 80% [CI 66-89%] and 83% [CI 72-90%], respectively (p = 0.689). All 33 surviving evaluable patients with a history of IBD experienced resolution of IBD by 2 years following allogeneic HCT.ConclusionsIn this cohort, allogeneic HCT was curative for CGD-associated IBD. IBD should not contraindicate HCT, as it does not lead to an increased risk of mortality. This study is registered at clinicaltrials.gov NCT02082353.

Published
2019

10. Role of the extent of prophylactic regional lymph node radiotherapy on survival in high‐risk neuroblastoma: A report from the COG A3973 study

Author

Braunstein, Steve E, London, Wendy B, Kreissman, Susan G, Villablanca, Judith G, Davidoff, Andrew M, DeSantes, Kenneth, Castleberry, Robert P, Murray, Kevin, Diller, Lisa, Matthay, Katherine, Cohn, Susan L, Shulkin, Barry, Allmen, Daniel, Parisi, Marguerite T, Ryn, Collin, Park, Julie R, Quaglia, Michael P, and Haas‐Kogan, Daphne A

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Pediatric Research Initiative, Patient Safety, Pediatric Cancer, Neurosciences, Neuroblastoma, Cancer, Rare Diseases, Transplantation, Pediatric, 6.5 Radiotherapy and other non-invasive therapies, 6.4 Surgery, Evaluation of treatments and therapeutic interventions, Disease-Free Survival, Female, Humans, Infant, Infant, Newborn, Lymph Nodes, Male, Survival Rate, high risk, lymph nodes, neuroblastoma, radiotherapy, Paediatrics and Reproductive Medicine, Oncology & Carcinogenesis, Oncology and carcinogenesis, Paediatrics
Abstract

PurposeNeuroblastoma is the most common extracranial solid pediatric malignancy, with poor outcomes in high-risk disease. Standard treatment approaches employ an increasing array of aggressive multimodal therapies, of which local control with surgery and radiotherapy remains a backbone; however, the benefit of broad regional nodal irradiation remains controversial. We analyzed centrally reviewed radiation therapy data from patients enrolled on COG A3973 to evaluate the impact of primary site irradiation and the extent of regional nodal coverage stratified by extent of surgical resection.MethodsThree hundred thirty high-risk neuroblastoma patients with centrally reviewed radiotherapy plans were analyzed. Outcome was evaluated by the extent of nodal irradiation. For the 171 patients who also underwent surgery (centrally reviewed), outcome was likewise analyzed according to the extent of resection. Overall survival (OS), event-free survival (EFS), and cumulative incidence of local progression (CILP) were examined by Kaplan-Meier, log-rank test (EFS, OS), and Grey test (CILP).ResultsThe five-year CILP, EFS, and OS for all 330 patients receiving radiotherapy on A3973 were 8.5% ± 1.5%, 47.2% ± 3.0%, and 59.7% ± 3.0%, respectively. There were no significant differences in outcomes based on the extent of lymph node irradiation regardless of the degree of surgical resection (

Published
2019

11. The genetic landscape of severe combined immunodeficiency in the United States and Canada in the current era (2010-2018).

Author

Dvorak, Christopher C, Haddad, Elie, Buckley, Rebecca H, Cowan, Morton J, Logan, Brent, Griffith, Linda M, Kohn, Donald B, Pai, Sung-Yun, Notarangelo, Luigi, Shearer, William, Prockop, Susan, Kapoor, Neena, Heimall, Jennifer, Chaudhury, Sonali, Shyr, David, Chandra, Sharat, Cuvelier, Geoff, Moore, Theodore, Shenoy, Shalini, Goldman, Fred, Smith, Angela R, Sunkersett, Gauri, Vander Lugt, Mark, Caywood, Emi, Quigg, Troy, Torgerson, Troy, Chandrakasan, Shanmuganathan, Craddock, John, Dávila Saldaña, Blachy J, Gillio, Alfred, Shereck, Evan, Aquino, Victor, DeSantes, Kenneth, Knutsen, Alan, Thakar, Monica, Yu, Lolie, and Puck, Jennifer M

Subjects
Humans, Severe Combined Immunodeficiency, Child, Child, Preschool, Infant, Infant, Newborn, Canada, United States, Female, Male, Good Health and Well Being, Immunology, Allergy
Abstract

In a 250 patient cohort from the US and Canada in the current era (2010–2018), we show that over 90% of patients with severe combined immunodeficiency (SCID) can be genetically-characterized.

Published
2019

12. Outcomes following treatment for ADA-deficient severe combined immunodeficiency: a report from the PIDTC

Author

Cuvelier, Geoffrey D.E., Logan, Brent R., Prockop, Susan E., Buckley, Rebecca H., Kuo, Caroline Y., Griffith, Linda M., Liu, Xuerong, Yip, Alison, Hershfield, Michael S., Ayoub, Paul G., Moore, Theodore B., Dorsey, Morna J., O'Reilly, Richard J., Kapoor, Neena, Pai, Sung-Yun, Kapadia, Malika, Ebens, Christen L., Forbes Satter, Lisa R., Burroughs, Lauri M., Petrovic, Aleksandra, Chellapandian, Deepak, Heimall, Jennifer, Shyr, David C., Rayes, Ahmad, Bednarski, Jeffrey J., Chandra, Sharat, Chandrakasan, Shanmuganathan, Gillio, Alfred P., Madden, Lisa, Quigg, Troy C., Caywood, Emi H., Dávila Saldaña, Blachy J., DeSantes, Kenneth, Eissa, Hesham, Goldman, Frederick D., Rozmus, Jacob, Shah, Ami J., Vander Lugt, Mark T., Thakar, Monica S., Parrott, Roberta E., Martinez, Caridad, Leiding, Jennifer W., Torgerson, Troy R., Pulsipher, Michael A., Notarangelo, Luigi D., Cowan, Morton J., Dvorak, Christopher C., Haddad, Elie, Puck, Jennifer M., and Kohn, Donald B.

Published
2022
Full Text
View/download PDF

13. Outcomes Following Matched Sibling Donor Transplant for Severe Combined Immunodeficiency: A Report from the Pidtc

Author

Rayes, Ahmad, primary, Logan, Brent, additional, Liu, Xuerong, additional, Dara, Jasmeen, additional, Buckley, Rebecca H., additional, Oved, Joseph H., additional, Kapoor, Neena, additional, Kapadia, Malika, additional, Chandra, Sharat, additional, Martinez, Caridad, additional, Bunin, Nancy J., additional, Chandrakasan, Shanmuganathan, additional, Burroughs, Lauri M., additional, Bednarski, Jeffrey J, additional, Haines, Hilary, additional, Cuvelier, Geoff D.E., additional, Eissa, Hesham, additional, Talano, Julie A, additional, Saldana, Blachy J, additional, Ebens, Christen L., additional, Chaudhury, Sonali, additional, Shereck, Evan, additional, Aquino, Victor, additional, Knutsen, Alan P., additional, Alexander, Jessie L, additional, Gillio, Alfred P., additional, Chellapandian, Deepak, additional, Shah, Ami J., additional, Miller, Holly K., additional, Lugt, Mark T. Vander, additional, DeSantes, Kenneth, additional, Dorsey, Morna, additional, Parrott, Roberta E, additional, O'Reilly, Richard J., additional, Aguayo-Hiraldo, Paibel, additional, Torgerson, Troy, additional, Leiding, Jennifer W., additional, Marsh, Rebecca A., additional, Griffith, Linda M., additional, Pulsipher, Mike A., additional, Kohn, Donald B., additional, Notarangelo, Luigi D., additional, Cowan, Morton J., additional, Puck, Jennifer, additional, Heimall, Jennifer R., additional, Haddad, Elie, additional, Pai, Sung-Yun, additional, and Dvorak, Christopher C., additional

Published
2024
Full Text
View/download PDF

15. Correction to: Infections in Infants with SCID: Isolation, Infection Screening and Prophylaxis in PIDTC Centers

Author

Dorsey, Morna, Wright, Nicola A. M., Chaimowitz, Natalia S., Dávila Saldaña, Blachy J., Miller, Holly, Keller, Michael D., Thakar, Monica S., Shah, Ami J., Abu-Arja, Rolla, Andolina, Jeffrey, Aquino, Victor, Barnum, J. L., Bednarski, Jeffrey J., Bhatia, Monica, Bonilla, Francisco A., Butte, Manish J., Bunin, Nancy J., Burroughs, Lauri M., Chandra, Sharat, Chaudhury, Sonali, Chen, Karin, Chong, Hey, Cuvelier, Geoff, Dalal, Jignesh, DeFelice, Magee L., DeSantes, Kenneth B., Forbes, Lisa R., Gillio, Alfred, Goldman, Fred, Joshi, Avni Y., Kapoor, Neena, Knutsen, Alan P., Kobrynski, Lisa, Lieberman, Jay A., Leiding, Jennifer W., Oshrine, Benjamin, Patel, Kiran P., Prockop, Susan, Quigg, Troy C., Quinones, Ralph, Schultz, Kirk R., Seroogy, Christine, Shyr, David, Siegel, Subhadra, Smith, Angela R., Torgerson, Troy R., Vander Lugt, Mark T., Yu, Lolie C., Cowan, Morton J., Buckley, Rebecca H., Dvorak, Christopher C., Griffith, Linda M., Haddad, Elie, Kohn, Donald B., Logan, Brent, Notarangelo, Luigi D., Pai, Sung-Yun, Puck, Jennifer, Pulsipher, Michael A., and Heimall, Jennifer

Published
2021
Full Text
View/download PDF

17. Posttransplantation late complications increase over time for patients with SCID: A Primary Immune Deficiency Treatment Consortium (PIDTC) landmark study

Author

Eissa, Hesham, primary, Thakar, Monica S., additional, Shah, Ami J., additional, Logan, Brent R., additional, Griffith, Linda M., additional, Dong, Huaying, additional, Parrott, Roberta E., additional, O’Reilly, Richard J., additional, Dara, Jasmeen, additional, Kapoor, Neena, additional, Forbes Satter, Lisa, additional, Chandra, Sharat, additional, Kapadia, Malika, additional, Chandrakasan, Shanmuganathan, additional, Knutsen, Alan, additional, Jyonouchi, Soma C., additional, Molinari, Lyndsay, additional, Rayes, Ahmad, additional, Ebens, Christen L., additional, Teira, Pierre, additional, Dávila Saldaña, Blachy J., additional, Burroughs, Lauri M., additional, Chaudhury, Sonali, additional, Chellapandian, Deepak, additional, Gillio, Alfred P., additional, Goldman, Fredrick, additional, Malech, Harry L., additional, DeSantes, Kenneth, additional, Cuvelier, Geoff D.E., additional, Rozmus, Jacob, additional, Quinones, Ralph, additional, Yu, Lolie C., additional, Broglie, Larisa, additional, Aquino, Victor, additional, Shereck, Evan, additional, Moore, Theodore B., additional, Vander Lugt, Mark T., additional, Mousallem, Talal I., additional, Oved, Joeseph H., additional, Dorsey, Morna, additional, Abdel-Azim, Hisham, additional, Martinez, Caridad, additional, Bleesing, Jacob H., additional, Prockop, Susan, additional, Kohn, Donald B., additional, Bednarski, Jeffrey J., additional, Leiding, Jennifer, additional, Marsh, Rebecca A., additional, Torgerson, Troy, additional, Notarangelo, Luigi D., additional, Pai, Sung-Yun, additional, Pulsipher, Michael A., additional, Puck, Jennifer M., additional, Dvorak, Christopher C., additional, Haddad, Elie, additional, Buckley, Rebecca H., additional, Cowan, Morton J., additional, and Heimall, Jennifer, additional

Published
2023
Full Text
View/download PDF

18. SCID genotype and 6-month posttransplant CD4 count predict survival and immune recovery

Author

Haddad, Elie, Logan, Brent R., Griffith, Linda M., Buckley, Rebecca H., Parrott, Roberta E., Prockop, Susan E., Small, Trudy N., Chaisson, Jessica, Dvorak, Christopher C., Murnane, Megan, Kapoor, Neena, Abdel-Azim, Hisham, Hanson, Imelda C., Martinez, Caridad, Bleesing, Jack J.H., Chandra, Sharat, Smith, Angela R., Cavanaugh, Matthew E., Jyonouchi, Soma, Sullivan, Kathleen E., Burroughs, Lauri, Skoda-Smith, Suzanne, Haight, Ann E., Tumlin, Audrey G., Quigg, Troy C., Taylor, Candace, Dávila Saldaña, Blachy J., Keller, Michael D., Seroogy, Christine M., Desantes, Kenneth B., Petrovic, Aleksandra, Leiding, Jennifer W., Shyr, David C., Decaluwe, Hélène, Teira, Pierre, Gillio, Alfred P., Knutsen, Alan P., Moore, Theodore B., Kletzel, Morris, Craddock, John A., Aquino, Victor, Davis, Jeffrey H., Yu, Lolie C., Cuvelier, Geoffrey D.E., Bednarski, Jeffrey J., Goldman, Frederick D., Kang, Elizabeth M., Shereck, Evan, Porteus, Matthew H., Connelly, James A., Fleisher, Thomas A., Malech, Harry L., Shearer, William T., Szabolcs, Paul, Thakar, Monica S., Vander Lugt, Mark T., Heimall, Jennifer, Yin, Ziyan, Pulsipher, Michael A., Pai, Sung-Yun, Kohn, Donald B., Puck, Jennifer M., Cowan, Morton J., O'Reilly, Richard J., and Notarangelo, Luigi D.

Published
2018
Full Text
View/download PDF

19. Immune reconstitution and survival of 100 SCID patients post–hematopoietic cell transplant: a PIDTC natural history study

Author

Heimall, Jennifer, Logan, Brent R., Cowan, Morton J., Notarangelo, Luigi D., Griffith, Linda M., Puck, Jennifer M., Kohn, Donald B., Pulsipher, Michael A., Parikh, Suhag, Martinez, Caridad, Kapoor, Neena, O'Reilly, Richard, Boyer, Michael, Pai, Sung-Yun, Goldman, Frederick, Burroughs, Lauri, Chandra, Sharat, Kletzel, Morris, Thakar, Monica, Connelly, James, Cuvelier, Geoff, Davila Saldana, Blachy J., Shereck, Evan, Knutsen, Alan, Sullivan, Kathleen E., DeSantes, Kenneth, Gillio, Alfred, Haddad, Elie, Petrovic, Aleksandra, Quigg, Troy, Smith, Angela R., Stenger, Elizabeth, Yin, Ziyan, Shearer, William T., Fleisher, Thomas, Buckley, Rebecca H., and Dvorak, Christopher C.

Published
2017
Full Text
View/download PDF

21. Event Free Survival in Severe Combined Immune Deficiency (SCID) Infants after Conditioned Umbilical Cord Blood Transplantation (UCBT) Benefits from Omitting Serotherapy

Author

Martinez, Caridad, primary, Logan, Brent, additional, Liu, Xuerong, additional, Dvorak, Christopher C., additional, Madden, Lisa, additional, Molinari, Lyndsay, additional, Cowan, Morton J., additional, Pai, Sung-Yun, additional, Haddad, Elie, additional, Puck, Jennifer, additional, Kohn, Donald B., additional, Griffith, Linda M., additional, Pulsipher, Michael, additional, Leiding, Jennifer W., additional, Notarangelo, Luigi D., additional, Torgerson, Troy, additional, Marsh, Rebecca A., additional, Cuvelier, Geoff D.E., additional, Prockop, Susan, additional, Buckley, Rebecca H., additional, Kuo, Caroline Y., additional, Yip, Alison, additional, Hershfield, Michael S., additional, Parrott, Roberta E, additional, Ebens, Christen L., additional, Moore, Theodore B., additional, O’Reilly, Richard J., additional, Kapadia, Malika, additional, Kapoor, Neena, additional, Satter, Lisa Forbes, additional, Burroughs, Lauri M., additional, Petrovic, Aleksandra, additional, Thakar, Monica S., additional, Chellapandian, Deepak, additional, Heimall, Jennifer R., additional, Shyr, David C., additional, Bednarski, Jeffrey J, additional, Rayes, Ahmad, additional, Chandrakasan, Shanmuganathan, additional, Quigg, Troy C., additional, Davila, Blachy J, additional, DeSantes, Kenneth, additional, Eissa, Hesham, additional, Goldman, Frederick, additional, Rozmus, Jacob, additional, Shah, Ami J, additional, Lugt, Mark Vander, additional, Keller, Michael D., additional, Sullivan, Kathleen E., additional, Jyonouchi, Soma, additional, Seroogy, Christine, additional, Decaluwe, Helene, additional, Teira, Pierre, additional, Knutsen, Alan P., additional, Kletzel, Morris, additional, Aquino, Victor, additional, Davis, Jeffrey H, additional, and Szabolcs, Paul, additional

Published
2023
Full Text
View/download PDF

22. Allogenic Hematopoietic Cell Transplantations Are Effective in Patients with p47phox Chronic Granulomatous Disease: A Primary Immune Deficiency Treatment Consortium Study

Author

Grunebaum, Eyal, primary, Arnold, Danielle E., additional, Logan, Brent, additional, Parikh, Suhag, additional, Marsh, Rebecca A., additional, Griffith, Linda M., additional, Mallhi, Kanwaldeep, additional, Chellapandian, Deepak, additional, Lim, Stephanie Si, additional, Deal, Christin L., additional, Murguía-Favela, Luis, additional, Mousallem, Talal I., additional, Prasad, Prof. Vinod K., additional, Teira, Pierre, additional, Touzot, Fabien, additional, Bunin, Nancy J., additional, Heimall, Jennifer R., additional, Burroughs, Lauri M., additional, Kapadia, Malika, additional, Prockop, Susan, additional, Chandra, Sharat, additional, Chandrakasan, Shanmuganathan, additional, Chaudhury, Sonali, additional, Broglie, Larisa, additional, O’Reilly, Richard J., additional, Dávila Saldaña, Blachy J., additional, Schaefer, Edo, additional, Chong, Hey, additional, Bednarski, Jeffrey J., additional, Rayes, Ahmad, additional, DeSantes, Kenneth, additional, Kohn, Donald B., additional, Notarangelo, Luigi D., additional, Pai, Sung-Yun, additional, Puck, Jennifer, additional, Torgerson, Troy, additional, Cowan, Morton J., additional, Dvorak, Christopher C., additional, Satter, Lisa Forbes, additional, Haddad, Elie, additional, Pulsipher, Michael, additional, Malech, Harry L., additional, Kang, Elizabeth M., additional, and Leiding, Jennifer W., additional

Published
2023
Full Text
View/download PDF

24. 116 - Event Free Survival in Severe Combined Immune Deficiency (SCID) Infants after Conditioned Umbilical Cord Blood Transplantation (UCBT) Benefits from Omitting Serotherapy

Author

Martinez, Caridad, Logan, Brent, Liu, Xuerong, Dvorak, Christopher C., Madden, Lisa, Molinari, Lyndsay, Cowan, Morton J., Pai, Sung-Yun, Haddad, Elie, Puck, Jennifer, Kohn, Donald B., Griffith, Linda M., Pulsipher, Michael, Leiding, Jennifer W., Notarangelo, Luigi D., Torgerson, Troy, Marsh, Rebecca A., Cuvelier, Geoff D.E., Prockop, Susan, Buckley, Rebecca H., Kuo, Caroline Y., Yip, Alison, Hershfield, Michael S., Parrott, Roberta E, Ebens, Christen L., Moore, Theodore B., O’Reilly, Richard J., Kapadia, Malika, Kapoor, Neena, Satter, Lisa Forbes, Burroughs, Lauri M., Petrovic, Aleksandra, Thakar, Monica S., Chellapandian, Deepak, Heimall, Jennifer R., Shyr, David C., Bednarski, Jeffrey J, Rayes, Ahmad, Chandrakasan, Shanmuganathan, Quigg, Troy C., Davila, Blachy J, DeSantes, Kenneth, Eissa, Hesham, Goldman, Frederick, Rozmus, Jacob, Shah, Ami J, Lugt, Mark Vander, Keller, Michael D., Sullivan, Kathleen E., Jyonouchi, Soma, Seroogy, Christine, Decaluwe, Helene, Teira, Pierre, Knutsen, Alan P., Kletzel, Morris, Aquino, Victor, Davis, Jeffrey H, and Szabolcs, Paul

Published
2023
Full Text
View/download PDF

28. 125 - Hematopoietic Cell Transplantation in 240 Patients with Chronic Granulomatous Disease: A Pidtc Report

Author

Arnold, Danielle E., Parikh, Suhag, Logan, Brent, Marsh, Rebecca, Griffith, Linda M., Wu, Ruizhe, Mallhi, Kanwaldeep, Chellapandian, Deepak, Si, Stephanie, Grunebaum, Eyal, Broglie, Larisa, Prasad, Vinod K., Heimall, Jennifer, Bunin, Nancy J., Teira, Pierre, Touzot, Fabien, Burroughs, Lauri M., Petrovic, Aleksandra, Bleesing, Jack J., Chandra, Sharat, Kapoor, Neena, Dara, Jasmeen, Dorsey, Morna, Williams, Olatundun, Kapadia, Malika, Bednarski, Jeffrey, Rayes, Ahmad, Chen, Karin, Chong, Hey, Cuvelier, Geoff D.E., Forbes, Lisa R., Martinez, Caridad, Vander Lugt, Mark T., Yu, Lolie C., Chandrakasan, Shanmuganathan, Joshi, Avni, Prockop, Susan E., Davila Saldana, Blachy J., Aquino, Victor, Ebens, Christen L., Madden, Lisa, DeSantes, Kenneth, Milner, Jordan, Rangarajan, Hemalatha G., Shah, Ami J, Gillio, Alfred P., Knutsen, Alan P., Miller, Holly K., Moore, Theodore B., Wright, Nicola, Cowan, Morton J., Dvorak, Christopher C., Haddad, Elie, Kohn, Donald B., Notarangelo, Luigi D., Pai, Sung-Yun, Puck, Jennifer, Pulsipher, Mike A., Torgerson, Troy, Malech, Harry L., Kang, Elizabeth M., and Leiding, Jennifer W.

Published
2022
Full Text
View/download PDF

29. Outcomes after Hematopoietic Cell Transplant and Gene Therapy for Adenosine Deaminase (ADA) Severe Combined Immune Deficiency: A Combined Analysis from the Primary Immune Deficiency Treatment Consortium (PIDTC) 6901 and 6902 Studies

Author

Cuvelier, Geoff D.E., primary, Logan, Brent, additional, Prockop, Susan E., additional, Buckley, Rebecca H., additional, Kuo, Caroline Y., additional, Griffith, Linda M., additional, Liu, Xuerong, additional, Yip, Alison, additional, Hershfield, Michael S., additional, Parrott, Roberta E, additional, Ebens, Christen L., additional, Moore, Theodore B., additional, O’Reilly, Richard J., additional, Pai, Sung-Yun, additional, Kapadia, Malika, additional, Kapoor, Neena, additional, Forbes Satter, Lisa R., additional, Martinez, Caridad, additional, Burroughs, Lauri M., additional, Petrovic, Aleksandra, additional, Thakar, Monica S., additional, Chellapandian, Deepak, additional, Heimall, Jennifer, additional, Shyr, David C., additional, Rayes, Ahmad, additional, Bednarski II, Jeffrey J., additional, Chandra, Sharat, additional, Chandrakasan, Shanmuganathan, additional, Gillio, Alfred P., additional, Madden, Lisa, additional, Quigg, Troy C., additional, Caywood, Emi H., additional, Dávila Saldaña, Blachy J, additional, DeSantes, Kenneth, additional, Eissa, Hesham, additional, Goldman, Frederick, additional, Rozmus, Jacob, additional, Shah, Ami J, additional, Vander Lugt, Mark T., additional, Pulsipher, Mike A., additional, Notarangelo, Luigi D., additional, Cowan, Morton J., additional, Dvorak, Christopher C., additional, Haddad, Elie, additional, Puck, Jennifer, additional, and Kohn, Donald B., additional

Published
2022
Full Text
View/download PDF

30. Hematopoietic Cell Transplantation in 240 Patients with Chronic Granulomatous Disease: A Pidtc Report

Author

Arnold, Danielle E., primary, Parikh, Suhag, additional, Logan, Brent, additional, Marsh, Rebecca, additional, Griffith, Linda M., additional, Wu, Ruizhe, additional, Mallhi, Kanwaldeep, additional, Chellapandian, Deepak, additional, Si, Stephanie, additional, Grunebaum, Eyal, additional, Broglie, Larisa, additional, Prasad, Vinod K., additional, Heimall, Jennifer, additional, Bunin, Nancy J., additional, Teira, Pierre, additional, Touzot, Fabien, additional, Burroughs, Lauri M., additional, Petrovic, Aleksandra, additional, Bleesing, Jack J., additional, Chandra, Sharat, additional, Kapoor, Neena, additional, Dara, Jasmeen, additional, Dorsey, Morna, additional, Williams, Olatundun, additional, Kapadia, Malika, additional, Bednarski, Jeffrey, additional, Rayes, Ahmad, additional, Chen, Karin, additional, Chong, Hey, additional, Cuvelier, Geoff D.E., additional, Forbes, Lisa R., additional, Martinez, Caridad, additional, Vander Lugt, Mark T., additional, Yu, Lolie C., additional, Chandrakasan, Shanmuganathan, additional, Joshi, Avni, additional, Prockop, Susan E., additional, Davila Saldana, Blachy J., additional, Aquino, Victor, additional, Ebens, Christen L., additional, Madden, Lisa, additional, DeSantes, Kenneth, additional, Milner, Jordan, additional, Rangarajan, Hemalatha G., additional, Shah, Ami J, additional, Gillio, Alfred P., additional, Knutsen, Alan P., additional, Miller, Holly K., additional, Moore, Theodore B., additional, Wright, Nicola, additional, Cowan, Morton J., additional, Dvorak, Christopher C., additional, Haddad, Elie, additional, Kohn, Donald B., additional, Notarangelo, Luigi D., additional, Pai, Sung-Yun, additional, Puck, Jennifer, additional, Pulsipher, Mike A., additional, Torgerson, Troy, additional, Malech, Harry L., additional, Kang, Elizabeth M., additional, and Leiding, Jennifer W., additional

Published
2022
Full Text
View/download PDF

31. A Primary Immune Deficiency Treatment Consortium (PIDTC) Study of Chronic and Late Onset Medical Complications after Initial Hematopoietic Cell Transplantation (HCT) for Severe Combined Immunodeficiency Disease (SCID)

Author

Eissa, Hesham, primary, Thakar, Monica S., additional, Shah, Ami J, additional, Buckley, Rebecca H., additional, Logan, Brent, additional, Griffith, Linda M., additional, Dong, Huaying, additional, O’Reilly, Richard J., additional, Kapoor, Neena, additional, Satter, Lisa Forbes, additional, Chandra, Sharat, additional, Bleesing, Jack J., additional, Kapadia, Malika, additional, Parrott, Roberta E, additional, Chandrakasan, Shanmuganathan, additional, Bednarski II, Jeffrey J., additional, Jyonouchi, Soma, additional, Madden, Lisa M., additional, Rayes, Ahmad, additional, Ebens, Christen L., additional, Teira, Pierre, additional, Dávila Saldaña, Blachy J, additional, Burroughs, Lauri M., additional, Prockop, Susan E., additional, Williams, Olatundun, additional, Chellapandian, Deepak, additional, Gillio, Alfred P., additional, Goldman, Frederick, additional, Malech, Harry L., additional, DeSantes, Kenneth, additional, Cuvelier, Geoff D.E., additional, Rozmus, Jacob, additional, Quinones, Ralph, additional, Yu, Lolie C., additional, Broglie, Larisa, additional, Aquino, Victor, additional, Shereck, Evan, additional, Moore, Theodore B., additional, Martinez, Caridad, additional, Vander Lugt, Mark T., additional, Leiding, Jennifer W., additional, Torgerson, Troy, additional, Pai, Sung-Yun, additional, Pulsipher, Mike A., additional, Notarangelo, Luigi D., additional, Puck, Jennifer, additional, Dvorak, Christopher C., additional, Haddad, Elie, additional, Cowan, Morton J., additional, and Heimall, Jennifer, additional

Published
2022
Full Text
View/download PDF

33. Correction to: Infections in Infants with SCID: Isolation, Infection Screening and Prophylaxis in PIDTC Centers

Author

Dorsey, Morna, primary, Wright, Nicola A. M., additional, Chaimowitz, Natalia S., additional, Dávila Saldaña, Blachy J., additional, Miller, Holly, additional, Keller, Michael D., additional, Thakar, Monica S., additional, Shah, Ami J., additional, Abu-Arja, Rolla, additional, Andolina, Jeffrey, additional, Aquino, Victor, additional, Barnum, J. L., additional, Bednarski, Jeffrey J., additional, Bhatia, Monica, additional, Bonilla, Francisco A., additional, Butte, Manish J., additional, Bunin, Nancy J., additional, Burroughs, Lauri M., additional, Chandra, Sharat, additional, Chaudhury, Sonali, additional, Chen, Karin, additional, Chong, Hey, additional, Cuvelier, Geoff, additional, Dalal, Jignesh, additional, DeFelice, Magee L., additional, DeSantes, Kenneth B., additional, Forbes, Lisa R., additional, Gillio, Alfred, additional, Goldman, Fred, additional, Joshi, Avni Y., additional, Kapoor, Neena, additional, Knutsen, Alan P., additional, Kobrynski, Lisa, additional, Lieberman, Jay A., additional, Leiding, Jennifer W., additional, Oshrine, Benjamin, additional, Patel, Kiran P., additional, Prockop, Susan, additional, Quigg, Troy C., additional, Quinones, Ralph, additional, Schultz, Kirk R., additional, Seroogy, Christine, additional, Shyr, David, additional, Siegel, Subhadra, additional, Smith, Angela R., additional, Torgerson, Troy R., additional, Vander Lugt, Mark T., additional, Yu, Lolie C., additional, Cowan, Morton J., additional, Buckley, Rebecca H., additional, Dvorak, Christopher C., additional, Griffith, Linda M., additional, Haddad, Elie, additional, Kohn, Donald B., additional, Logan, Brent, additional, Notarangelo, Luigi D., additional, Pai, Sung-Yun, additional, Puck, Jennifer, additional, Pulsipher, Michael A., additional, and Heimall, Jennifer, additional

Published
2020
Full Text
View/download PDF

35. 382 - Allogenic Hematopoietic Cell Transplantations Are Effective in Patients with p47phox Chronic Granulomatous Disease: A Primary Immune Deficiency Treatment Consortium Study

Author

Grunebaum, Eyal, Arnold, Danielle E., Logan, Brent, Parikh, Suhag, Marsh, Rebecca A., Griffith, Linda M., Mallhi, Kanwaldeep, Chellapandian, Deepak, Lim, Stephanie Si, Deal, Christin L., Murguía-Favela, Luis, Mousallem, Talal I., Prasad, Prof. Vinod K., Teira, Pierre, Touzot, Fabien, Bunin, Nancy J., Heimall, Jennifer R., Burroughs, Lauri M., Kapadia, Malika, Prockop, Susan, Chandra, Sharat, Chandrakasan, Shanmuganathan, Chaudhury, Sonali, Broglie, Larisa, O’Reilly, Richard J., Dávila Saldaña, Blachy J., Schaefer, Edo, Chong, Hey, Bednarski, Jeffrey J., II, Rayes, Ahmad, DeSantes, Kenneth, Kohn, Donald B., Notarangelo, Luigi D., Pai, Sung-Yun, Puck, Jennifer, Torgerson, Troy, Cowan, Morton J., Dvorak, Christopher C., Satter, Lisa Forbes, Haddad, Elie, Pulsipher, Michael, Malech, Harry L., Kang, Elizabeth M., and Leiding, Jennifer W.

Published
2023
Full Text
View/download PDF

38. Contributors

Author

Albritton, Karen, primary, Amatruda, James F., additional, Anderson, Megan E., additional, Argani, Pedram, additional, Armstrong, Scott A., additional, Baker, Sharyn D., additional, Barfield, Raymond C., additional, Barr, Frederic G., additional, Berde, Charles B., additional, Berman, Jason N., additional, Bernstein, Mark L., additional, Bhatia, Smita, additional, Billett, Amy Louise, additional, Blackman, Samuel, additional, Branowicki, Patricia A., additional, Casey, Robert L., additional, Chi, Susan N., additional, Clark, Jennifer J., additional, Conley, Susanne B., additional, Davis, Ian J., additional, Degar, Barbara A., additional, DeSantes, Kenneth B., additional, Diller, Lisa, additional, Dome, Jeffrey S., additional, DuBois, Steven G., additional, Duncan, Janet, additional, Dunn, Ian F., additional, Evan, Elana E., additional, Evans, William E., additional, Felix, Carolyn A., additional, Ferrando, Adolfo A., additional, Fisher, David E., additional, Fleming, Mark D., additional, Fletcher, Jonathan A., additional, Folkman, Judah, additional, Frazier, A. Lindsay, additional, Gebhardt, Mark C., additional, George, Rani E., additional, Goldberg, John M., additional, Gorlick, Richard, additional, Grabowski, Eric F., additional, Grier, Holcombe E., additional, Haas-Kogan, Daphne, additional, Hahn, William C., additional, Herrington, Betsy, additional, Houlahan, Kathleen E., additional, Italiano, Joseph E., additional, Janeway, Katherine A., additional, Kenney, Lisa B., additional, Kieran, Mark W., additional, Kim, Heung Bae, additional, Kiss, Szilárd, additional, Kodish, Eric, additional, Koh, Andrew Y., additional, Lechpammer, Mirna, additional, Leiderman, Yannek I., additional, Lessnick, Stephen L., additional, Look, A. Thomas, additional, Mack, Jennifer W., additional, Marcus, Karen J., additional, Mukai, Shizuo, additional, Mullen, Elizabeth, additional, O'Sullivan, Maureen J., additional, Pappo, Alberto, additional, Perez-Atayde, Antonio R., additional, Pizzo, Philip A., additional, Prabhu, Sanjay P., additional, Recklitis, Christopher J., additional, Reiter, Alfred, additional, Roberts, Charles W.M., additional, Robison, Leslie L., additional, Rollins, Barrett J., additional, Samuel, David, additional, Schlis, Krysta D., additional, Segal, Rosalind A., additional, Sellers, William R., additional, Shamberger, Robert C., additional, Shusterman, Suzanne, additional, Silverman, Lewis B., additional, Sondel, Paul M., additional, Sparreboom, Alex, additional, Stegmaier, Kimberly, additional, Tomlinson, Gail E., additional, Turner, Christopher, additional, Ullrich, Christina K., additional, Voss, Stephan D., additional, Vrooman, Lynda M., additional, Weldon, Christopher B., additional, Whangbo, Jennifer, additional, Wolfe, Joanne, additional, Womer, Richard B., additional, and Zeltzer, Lonnie, additional

Published
2009
Full Text
View/download PDF

39. Infections in Infants with SCID: Isolation, Infection Screening, and Prophylaxis in PIDTC Centers

Author

Dorsey, Morna J., primary, Wright, Nicola A. M., additional, Chaimowitz, Natalia S., additional, Dávila Saldaña, Blachy J., additional, Miller, Holly, additional, Keller, Michael D., additional, Thakar, Monica S., additional, Shah, Ami J., additional, Abu-Arja, Rolla, additional, Andolina, Jeffrey, additional, Aquino, Victor, additional, Barnum, J. L., additional, Bednarski, Jeffrey J., additional, Bhatia, Monica, additional, Bonilla, Francisco A., additional, Butte, Manish J., additional, Bunin, Nancy J., additional, Chandra, Sharat, additional, Chaudhury, Sonali, additional, Chen, Karin, additional, Chong, Hey, additional, Cuvelier, Geoffrey D. E., additional, Dalal, Jignesh, additional, DeFelice, Magee L., additional, DeSantes, Kenneth B., additional, Forbes, Lisa R., additional, Gillio, Alfred, additional, Goldman, Fred, additional, Joshi, Avni Y., additional, Kapoor, Neena, additional, Knutsen, Alan P., additional, Kobrynski, Lisa, additional, Lieberman, Jay A., additional, Leiding, Jennifer W., additional, Oshrine, Benjamin, additional, Patel, Kiran P., additional, Prockop, Susan, additional, Quigg, Troy C., additional, Quinones, Ralph, additional, Schultz, Kirk R., additional, Seroogy, Christine, additional, Shyr, David, additional, Siegel, Subhadra, additional, Smith, Angela R., additional, Torgerson, Troy R., additional, Vander Lugt, Mark T., additional, Yu, Lolie C., additional, Cowan, Morton J., additional, Buckley, Rebecca H., additional, Dvorak, Christopher C., additional, Griffith, Linda M., additional, Haddad, Elie, additional, Kohn, Donald B., additional, Logan, Brent, additional, Notarangelo, Luigi D., additional, Pai, Sung-Yun, additional, Puck, Jennifer, additional, Pulsipher, Michael A., additional, and Heimall, Jennifer, additional

Published
2020
Full Text
View/download PDF

41. Excellent outcomes following hematopoietic cell transplantation for Wiskott-Aldrich syndrome: a PIDTC report

Author

Burroughs, Lauri M., primary, Petrovic, Aleksandra, primary, Brazauskas, Ruta, primary, Liu, Xuerong, primary, Griffith, Linda M., primary, Ochs, Hans D., primary, Bleesing, Jack J., primary, Edwards, Stephanie, primary, Dvorak, Christopher C., primary, Chaudhury, Sonali, primary, Prockop, Susan E., primary, Quinones, Ralph, primary, Goldman, Frederick D., primary, Quigg, Troy C., primary, Chandrakasan, Shanmuganathan, primary, Smith, Angela R., primary, Parikh, Suhag, primary, Dávila Saldaña, Blachy J., primary, Thakar, Monica S., primary, Phelan, Rachel, primary, Shenoy, Shalini, primary, Forbes, Lisa R., primary, Martinez, Caridad, primary, Chellapandian, Deepak, primary, Shereck, Evan, primary, Miller, Holly K., primary, Kapoor, Neena, primary, Barnum, Jessie L., primary, Chong, Hey, primary, Shyr, David C., primary, Chen, Karin, primary, Abu-Arja, Rolla, primary, Shah, Ami J., primary, Weinacht, Katja G., primary, Moore, Theodore B., primary, Joshi, Avni, primary, DeSantes, Kenneth B., primary, Gillio, Alfred P., primary, Cuvelier, Geoffrey D. E., primary, Keller, Michael D., primary, Rozmus, Jacob, primary, Torgerson, Troy, primary, Pulsipher, Michael A., primary, Haddad, Elie, primary, Sullivan, Kathleen E., primary, Logan, Brent R., primary, Kohn, Donald B., primary, Puck, Jennifer M., primary, Notarangelo, Luigi D., primary, Pai, Sung-Yun, primary, Rawlings, David J., primary, and Cowan, Morton J., primary

Published
2020
Full Text
View/download PDF

42. Isobaric Labeling Strategy Utilizing 4-Plex N,N-Dimethyl Leucine (DiLeu) Tags Reveals Proteomic Changes Induced by Chemotherapy in Cerebrospinal Fluid of Children with B-Cell Acute Lymphoblastic Leukemia

Author

Yu, Qinying, primary, Zhong, Xiaofang, additional, Chen, Bingming, additional, Feng, Yu, additional, Ma, Min, additional, Diamond, Carol A., additional, Voeller, Julie S., additional, Kim, Miriam, additional, DeSantes, Kenneth B., additional, Capitini, Christian M., additional, Patel, Neha J., additional, Hoover-Regan, Margo L., additional, Burke, Michael J., additional, Janko, Kimberly, additional, Puccetti, Diane M., additional, Ikonomidou, Chrysanthy, additional, and Li, Lingjun, additional

Published
2020
Full Text
View/download PDF

43. Transplantation Outcomes for Children with Severe Combined Immune Deficiency (SCID) Have Improved over Time: A 36-Year Summary Report By the Primary Immune Deficiency Treatment Consortium (PIDTC)

Author

Thakar, Monica S., primary, Logan, Brent, additional, Buckley, Rebecca H., additional, Haddad, Elie, additional, Dvorak, Christopher C., additional, O'Reilly, Richard J., additional, Kapoor, Neena, additional, Satter, Lisa Forbes, additional, Martinez, Caridad, additional, Pai, Sung-Yun, additional, Heimall, Jennifer, additional, Jyonouchi, Soma, additional, Sullivan, Kathleen E., additional, Chandra, Sharat, additional, Smith, Angela R., additional, Chaudhury, Sonali, additional, Saldana, Blachy Davila, additional, Sunkersett, Gauri, additional, Shyr, David C., additional, Burroughs, Lauri M., additional, Petrovic, Aleksandra, additional, Quigg, Troy C., additional, Shenoy, Shalini, additional, Bednarski, Jeffrey J., additional, DeSantes, Kenneth, additional, Cuvelier, Geoff D.E., additional, Chandrakasan, Shanmuganathan, additional, Gillio, Alfred P., additional, Knutsen, Alan P., additional, Eissa, Hesham, additional, Goldman, Frederick, additional, Moore, Theodore B., additional, Aquino, Victor, additional, Shereck, Evan, additional, Lugt, Mark Vander, additional, Caywood, Emi H., additional, Yu, Lolie C., additional, Rozmus, Jacob, additional, Talano, Julie-An M., additional, Malech, Harry L., additional, Shah, Ami J., additional, Abu-Arja, Rolla, additional, Miller, Holly K., additional, Bani-Hashemi, Tara, additional, Chang, Catherine K., additional, Dunn, Elizabeth, additional, Torgerson, Troy, additional, Pulsipher, Michael A., additional, Griffith, Linda M., additional, Cowan, Morton J., additional, Kohn, Donald B., additional, Puck, Jennifer, additional, and Notarangelo, Luigi D., additional

Published
2020
Full Text
View/download PDF

44. Pediatric Acute Lymphoblastic Leukemia, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology

Author

Brown, Patrick, primary, Inaba, Hiroto, additional, Annesley, Colleen, additional, Beck, Jill, additional, Colace, Susan, additional, Dallas, Mari, additional, DeSantes, Kenneth, additional, Kelly, Kara, additional, Kitko, Carrie, additional, Lacayo, Norman, additional, Larrier, Nicole, additional, Maese, Luke, additional, Mahadeo, Kris, additional, Nanda, Ronica, additional, Nardi, Valentina, additional, Rodriguez, Vilmarie, additional, Rossoff, Jenna, additional, Schuettpelz, Laura, additional, Silverman, Lewis, additional, Sun, Jessica, additional, Sun, Weili, additional, Teachey, David, additional, Wong, Victor, additional, Yanik, Gregory, additional, Johnson-Chilla, Alyse, additional, and Ogba, Ndiya, additional

Published
2020
Full Text
View/download PDF

47. 437 - A Primary Immune Deficiency Treatment Consortium (PIDTC) Study of Chronic and Late Onset Medical Complications after Initial Hematopoietic Cell Transplantation (HCT) for Severe Combined Immunodeficiency Disease (SCID)

Author

Eissa, Hesham, Thakar, Monica S., Shah, Ami J, Buckley, Rebecca H., Logan, Brent, Griffith, Linda M., Dong, Huaying, O’Reilly, Richard J., Kapoor, Neena, Satter, Lisa Forbes, Chandra, Sharat, Bleesing, Jack J., Kapadia, Malika, Parrott, Roberta E, Chandrakasan, Shanmuganathan, Bednarski II, Jeffrey J., Jyonouchi, Soma, Madden, Lisa M., Rayes, Ahmad, Ebens, Christen L., Teira, Pierre, Dávila Saldaña, Blachy J, Burroughs, Lauri M., Prockop, Susan E., Williams, Olatundun, Chellapandian, Deepak, Gillio, Alfred P., Goldman, Frederick, Malech, Harry L., DeSantes, Kenneth, Cuvelier, Geoff D.E., Rozmus, Jacob, Quinones, Ralph, Yu, Lolie C., Broglie, Larisa, Aquino, Victor, Shereck, Evan, Moore, Theodore B., Martinez, Caridad, Vander Lugt, Mark T., Leiding, Jennifer W., Torgerson, Troy, Pai, Sung-Yun, Pulsipher, Mike A., Notarangelo, Luigi D., Puck, Jennifer, Dvorak, Christopher C., Haddad, Elie, Cowan, Morton J., and Heimall, Jennifer

Published
2022
Full Text
View/download PDF

48. 124 - Outcomes after Hematopoietic Cell Transplant and Gene Therapy for Adenosine Deaminase (ADA) Severe Combined Immune Deficiency: A Combined Analysis from the Primary Immune Deficiency Treatment Consortium (PIDTC) 6901 and 6902 Studies

Author

Cuvelier, Geoff D.E., Logan, Brent, Prockop, Susan E., Buckley, Rebecca H., Kuo, Caroline Y., Griffith, Linda M., Liu, Xuerong, Yip, Alison, Hershfield, Michael S., Parrott, Roberta E, Ebens, Christen L., Moore, Theodore B., O’Reilly, Richard J., Pai, Sung-Yun, Kapadia, Malika, Kapoor, Neena, Forbes Satter, Lisa R., Martinez, Caridad, Burroughs, Lauri M., Petrovic, Aleksandra, Thakar, Monica S., Chellapandian, Deepak, Heimall, Jennifer, Shyr, David C., Rayes, Ahmad, Bednarski II, Jeffrey J., Chandra, Sharat, Chandrakasan, Shanmuganathan, Gillio, Alfred P., Madden, Lisa, Quigg, Troy C., Caywood, Emi H., Dávila Saldaña, Blachy J, DeSantes, Kenneth, Eissa, Hesham, Goldman, Frederick, Rozmus, Jacob, Shah, Ami J, Vander Lugt, Mark T., Pulsipher, Mike A., Notarangelo, Luigi D., Cowan, Morton J., Dvorak, Christopher C., Haddad, Elie, Puck, Jennifer, and Kohn, Donald B.

Published
2022
Full Text
View/download PDF

49. The Genetic Landscape of SCID in the US and Canada in the Current Era (2010–2018)

Author

Dvorak, Christopher C., Haddad, Elie, Buckley, Rebecca H., Cowan, Morton J., Logan, Brent, Griffith, Linda M., Kohn, Donald B., Pai, Sung-Yun, Notarangelo, Luigi, Shearer, William, Prockop, Susan, Kapoor, Neena, Heimall, Jennifer, Chaudhury, Sonali, Shyr, David, Chandra, Sharat, Cuvelier, Geoff, Moore, Theodore, Shenoy, Shalini, Goldman, Fred, Smith, Angela R., Sunkersett, Gauri, Lugt, Mark Vander, Caywood, Emi, DO, Troy Quigg, Torgerson, Troy, Chandrakasan, Shan, Craddock, John, Dávila Saldaña, Blachy J., Gillio, Alfred, Shereck, Evan, Aquino, Victor, DeSantes, Kenneth, Knutsen, Alan, Thakar, Monica, Yu, Lolie, and Puck, Jennifer M.

Subjects
Male, Canada, fungi, Infant, Newborn, food and beverages, Infant, macromolecular substances, Article, United States, Child, Preschool, Humans, Female, Severe Combined Immunodeficiency, Child
Abstract

In a 250 patient cohort from the US and Canada in the current era (2010–2018), we show that over 90% of patients with severe combined immunodeficiency (SCID) can be genetically-characterized.

Published
2018

50. Resolution of CGD Related Colitis after Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Chronic Granulomatous Disease—Early Results From the 6903 Study of the Primary Immune Deficiency Treatment Consortium (PIDTC)

Author

Leiding, Jennifer W., primary, Logan, Brent R., additional, Yin, Ziyan, additional, Arbuckle, Erin, additional, Bleesing, Jack J., additional, Sullivan, Kathleen E., additional, Heimall, Jennifer, additional, Burroughs, Lauri, additional, Skoda-Smith, Suzanne, additional, Chandrakasan, Shanmuganathan, additional, Yu, Lolie C., additional, Oshrine, Benjamin R., additional, Cuvelier, Geoff D.E., additional, Thakar, Monica, additional, Chen, Karin, additional, Shenoy, Shalini, additional, Saldana, Blachy Davila, additional, Weinacht, Katja G., additional, Joshi, Avni, additional, Boulad, Farid, additional, Quigg, Troy C., additional, Dvorak, Christopher C., additional, Knutsen, Alan, additional, Chong, Hey, additional, Miller, Holly K., additional, de la Morena, M. Teresa, additional, DeSantes, Kenneth, additional, Cowan, Morton J., additional, Notarangelo, Luigi D., additional, Kohn, Donald B., additional, Pai, Sung-Yun, additional, Stenger, Elizabeth, additional, Puck, Jennifer, additional, Kapoor, Neena, additional, Pulsipher, Michael A., additional, Haddad, Elie, additional, Griffith, Linda M., additional, Shearer, William, additional, Malech, Harry L., additional, Parikh, Suhag, additional, Marsh, Rebecca A., additional, and Kang, Elizabeth M., additional

Published
2018
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results