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6. Ligament Lesions: Cell Therapy

Author

Dean, Robert S., DePhillipo, Nicholas N., LaPrade, Robert F., Filardo, Giuseppe, editor, Mandelbaum, Bert R., editor, Muschler, George F., editor, Rodeo, Scott A., editor, and Nakamura, Norimasa, editor

Published
2022
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7. List of contributors

Author

Abboud, Joseph, primary, Akhnoukh, Kyrillos M., additional, Alexandrov, Alexander, additional, Aljabi, Anas, additional, Arce, Giuliana Colombari, additional, Arias, Daniel, additional, Avendaño Capriles, Camilo Andres, additional, Azarpey, Ali, additional, Bach, Vu N., additional, Baez, Catalina, additional, Belzie, Alissa, additional, Best, Matthew J., additional, Beyer, Julia, additional, Bishop, Meghan E., additional, Bogdan, Paulina, additional, Bouck, Trevor, additional, Boyd, Brandon, additional, Brown, Bryanna, additional, Campbell, Michael P., additional, Capotosto, Salvatore, additional, Cardiel Castro, Luis Felipe, additional, Carlos, Noel Bien Tan, additional, Carrasco, Felipe, additional, Cedeno-Serna, Juan, additional, Chang, Jaewon, additional, Chang, Edward S., additional, Chen, Christine, additional, Clark, Philip, additional, Cloud, Geoffrey, additional, Coco, Laura, additional, Cohen, Brian H., additional, Conway, Charles, additional, Cortina, Carolina Campuzano, additional, Cox, Ryan M., additional, Coyner, Katherine, additional, Crasto, Cameron, additional, Cury Perea, Ines Yaritza, additional, Del Re, Andrew, additional, DePhillipo, Nicholas N., additional, Diamond, Keith Brett, additional, DiCosmo, Michael B., additional, Dixit, Meehir, additional, Dollar, Christina M., additional, Donovan, Luke, additional, Duffield, Tyler C., additional, Elattar, Osama, additional, Elbin, R.J., additional, Elphingstone, Joseph, additional, Emara, Ahmed, additional, Erez, Orry, additional, Escobar, María Fernanda, additional, Ettenhofer, Mark L., additional, Fackler, Nathan P., additional, Fallon, Ryan T., additional, Fayed, Aly M., additional, Ferlic, Mason, additional, Fernández-Cásseres, María A., additional, Fertala, Andrzej, additional, Figueras, Jorge H., additional, Freedman, Kevin B., additional, Gallun, Frederick J., additional, Garcia, John Paul, additional, Ginalis, Elizabeth E., additional, Grawe, Brian M., additional, Gruffi, Lauren, additional, Guettler, Joseph, additional, Harrison, Laura, additional, Hart, Joe, additional, Hartnett, Davis A., additional, Henriquez Abramuk, Maria F., additional, Hevesi, Mario, additional, Holodinsky, Jessalyn K., additional, Horn, Andrew, additional, Ibrahim, Zainab, additional, Idrizi, Adem, additional, Ignacio, Gian Christian T., additional, Imankhan, Mahshid, additional, Imas, Alexander S., additional, Jain, Shreya, additional, Jami, Meghana, additional, Jan, Kyleen, additional, Jason Wong, Che Hang, additional, Jawa, Andrew, additional, Jimenez Mosquea, Thelma R., additional, Joshi, Pinak, additional, Kamada, Sneha, additional, Kang, Kevin K., additional, Kassam, Hafiz F., additional, Khan, Nabil Z., additional, King, James A., additional, Klifto, Christopher, additional, Knebels, Rebecca, additional, Koch, Christopher, additional, Kossman, Melissa K., additional, Kothari, Ezan, additional, Kremen, Thomas J., additional, Krivicich, Laura M., additional, Kucera, Kristen L., additional, Kuenze, Christopher M., additional, Kutschke, Michael, additional, Lacouture, Salomon Abuchaibe, additional, Lacouture Cardenas, Natalia Andrea, additional, Lam, Aaron, additional, Langner Salinas, Fabiola, additional, Lepley, Adam S., additional, Libreros-Peña, Laura, additional, Liu, Jonathan, additional, Liu, Sean, additional, Lohre, Ryan, additional, Luthringer, Tyler A., additional, Magruder, Matthew, additional, Maheshwer, Bhargavi, additional, Manzur-Pineda, Karen, additional, Marcaccio, Stephen E., additional, Martínez-Robles, Karen J., additional, Mercado Rueda, Anette Paulin, additional, Mescher, Patrick, additional, Mihas, Alexander, additional, Mikula, Jacob D., additional, Miller, Jacob D., additional, Milner, John D., additional, Moattari, Kevin, additional, Mowery, Alia J., additional, Murthi, Anand M., additional, Musharbash, Farah N., additional, Nassis, Electra, additional, Ng, Mitchell K., additional, Nho, Shane J., additional, Norte, Grant E., additional, Nwosu, Chinemerem, additional, Ocoro Vallecilla, Arnold, additional, Orellana, Manuel A., additional, Oshobu, Ibukunolowa, additional, Padilla, José Carlos, additional, Paracha, Noorulain, additional, Patel, Sneha, additional, Paul, Ryan W., additional, Pereira Zapata, Paula Andrea, additional, Peña-Zárate, Evelyn E., additional, Philips, Alexander P., additional, Pill, Stephan G., additional, Piuzzi, Nicolas, additional, Quan, Theodore, additional, Quinn, Matthew, additional, Quinoa, Travis R., additional, Ramtin, Sina, additional, Razi, Afshin E., additional, Rondon, Alexander J., additional, Russi-Pulgar, Daniela, additional, Saad, Maarouf, additional, Sabharwal, Samir, additional, Sanchez, Giovanni, additional, Sanders, James, additional, Sanko, Cassandra, additional, Shah, Armaan, additional, Shaw, Jesse, additional, Sheth, Bhavya K., additional, Sheth, Divya K., additional, Shi, Brendan Y., additional, Singh, Rohanit, additional, Sinkler, Margaret A., additional, Sohn, David H., additional, Sonnier, John Hayden, additional, Srikumaran, Uma, additional, Sriram, Varun, additional, Stoll, Kurt Edward, additional, Strassburg, Alyssa, additional, Sullivan, Camille, additional, Suresh, Krishna V., additional, Suresh, Sukrit, additional, Tamayo-Torres, Claudia Sofía, additional, Testa, Edward J., additional, Thamer, Semran B., additional, Thomson, Cameron G., additional, Titter, Julie, additional, Torrez, Timothy, additional, Toy, Kristin, additional, Tranovich, Meaghan, additional, Vakharia, Rushabh M., additional, Valentino, Nicolás, additional, Valenzuela-Vallejo, Laura, additional, van Eck, Carola F., additional, Varghese, Priscilla, additional, Varzhapetyan, Vahe, additional, Vaughan, Alayna K., additional, Vingan, Perri, additional, Vippa, Tarun K., additional, Williams, Kevin, additional, Williamson, Tyler, additional, Womble, Melissa, additional, Wright, Melissa A., additional, Wu, Shannon Y., additional, Xylas, Diamantis, additional, Yañez-Sarmiento, Anamaria, additional, and Ziauddin, Lubna, additional

Published
2023
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20. List of Contributors

Author

Abat, Ferran, primary, Arakgi, Michelle E., additional, Arendt, Elizabeth A., additional, Argentieri, Erin C., additional, Bartels, Douglas W., additional, Baumann, Charles A., additional, Beletsky, Alexander, additional, Bhatia, Sanjeev, additional, Braun, Tatum W., additional, Brown, Charles H., additional, Burge, Alissa J., additional, Burnett, Robert A., additional, Cancienne, Jourdan M., additional, Chahla, Jorge, additional, Chilelli, Brian, additional, Christino, Melissa A., additional, Cole, Brian J., additional, Cosgarea, Andrew J., additional, Cotter, Eric J., additional, Cregar, William M., additional, Damasena, Iswadi, additional, Dean, Robert S., additional, DeJour, David, additional, Delaloye, Jean Romain, additional, DePhillipo, Nicholas N., additional, Diermeier, Theresa, additional, DiFelice, Gregory S., additional, Ellman, Michael B., additional, Ence, Andrew K., additional, Engebretsen, Lars, additional, Farr, Jack, additional, Franck, Florent, additional, Frank, Rachel M., additional, Fritsch, Brett A., additional, Fu, Freddie H., additional, Fulkerson, John P., additional, Graden, Nathan R., additional, Geeslin, Andrew G., additional, Gelber, Pablo Eduardo, additional, Getgood, Alan, additional, Gilat, Ron, additional, Giordanelli, Matthew D., additional, Gomoll, Andreas, additional, Görtz, Simon, additional, Hinckel, Betina B., additional, Huddleston, Hailey P., additional, Kahat, David H., additional, Kane, Patrick, additional, Kennedy, Nicholas I., additional, Kocher, Mininder S., additional, Kunze, Kyle N., additional, Krych, Aaron J., additional, LaGreca, Jaren, additional, LaPrade, Robert F., additional, Lattermann, Christian, additional, LeBus, George, additional, Levy, Bruce A., additional, Lind, Martin, additional, Linklater, James P., additional, Loeb, Alexander E., additional, Macalena, Jeffrey A., additional, Mandelbaum, Bert, additional, Martin, R. Kyle, additional, Meredith, Sean J., additional, Mitchell, Justin J., additional, Moatshe, Gilbert, additional, Monibi, Farrah A., additional, Mueller, Brett, additional, Musahl, Volker, additional, Muzzi, Stefano, additional, O’Brien, Luke T., additional, Perkins, Crystal A., additional, Pioger, Charles, additional, Potter, Hollis G., additional, Pujol, Nicolas, additional, Putnis, Sven E., additional, Raynor, Martin Brett, additional, Rodeo, Scott A., additional, Saithna, Adnan, additional, Scheidt, Michael, additional, Scholz, Henry D., additional, Siljander, Breana, additional, Slone, Harris S., additional, Smigielski, Robert, additional, Sonnery-Cottet, Bertrand, additional, Spalding, Tim, additional, Strauss, Marc, additional, Tabbaa, Suzanne M., additional, Tagliero, Adam J., additional, Tanaka, Miho J., additional, Tauro, Tracy, additional, Teitge, Robert A., additional, Torres-Claramunt, Raúl, additional, van der List, Jelle P., additional, Verdonk, Peter, additional, Vermeijden, Harmen D., additional, Vieira, Thais Dutra, additional, Williams, Brady T., additional, Willimon, S. Clifton, additional, Wise, Kelsey L., additional, Xerogeanes, John W., additional, Yanke, Adam B., additional, and Zochowski, Kelly C., additional

Published
2022
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30. Meniscal extrusion consensus statement: A collaborative survey within the Meniscus International Network (MenIN) Study Group.

Author

Familiari, Filippo, Chahla, Jorge, Compagnoni, Riccardo, DePhillipo, Nicholas N., Moatshe, Gilbert, LaPrade, Robert F., Adravanti, Paolo, Bait, Corrado, Beaufils, Philippe, Becker, Roland, Calafiore, Giuseppe, Cancienne, Jourdan, Chan, Kai‐Ming, Cole, Brian J., Condello, Vincenzo, D'Hooghe, Pieter, Dekker, Travis J., Engebretsen, Lars, Espregueira‐Mendes, João, and Faucett, Scott C.

Subjects
MENISCUS injuries, MAGNETIC resonance imaging, KNEE osteoarthritis, BODY mass index
Abstract

Purpose: The purpose of the present study was to perform a survey administered to members of the Meniscus International Network (MenIN) Study Group, seeking to delineate the most contentious aspects of meniscal extrusion classification and provide a foundation for new, more comprehensive definitions and treatments for these pathologies. Methods: MenIN Study Group is a group of international experts treating and performing research on meniscus pathology and treatment. All MenIN Study Group members were asked to complete a survey aimed at establishing criteria for the optimal classification system for meniscal extrusion. Data obtained from the completed questionnaires were transferred into a spreadsheet and then analysed. All responses are presented as counts, percentages or means. Results: Forty‐seven (85.5%) MenIN Study Group members completed the survey and were included in this analysis. Key aspects recommended for inclusion in a comprehensive classification system for meniscal extrusion included laterality (93.6%), anatomical location (76.6%), patient age (76.6%), body mass index (BMI) (68.1%) and aetiology (68.1%). For classifying meniscal extrusion, 53.2% considered the distance in millimetres from the tibial plateau's outer margin as the most reliable measurement technique on imaging. Preferences for imaging modalities varied, with 44.7% favouring weight‐bearing magnetic resonance imaging (MRI) and 36.2% opting for weight‐bearing ultrasound due to its greater availability. Respondents advocated for a classification system addressing stability or progression of meniscal extrusion (66%), reducibility (53.2%), potential progression of knee osteoarthritis (OA) (83%), influencing treatment approaches (83%), a gradation system (83%), consideration of dynamic factors (66%), association with clinical outcomes and prognosis (76.6%) and investigation around centralization procedures (57.4%). Conclusions: In conclusion, the findings of this survey shed light on the global perspectives regarding meniscal extrusion classification. It was generally felt that a new classification of extrusion measured on MRI scans at the mid‐tibial plateau should be developed, which considers factors such as laterality, anatomical location, age, BMI and aetiology. Additionally, the results support the integration of dynamic factors and clinical outcomes in MRI‐based classifications to inform treatment approaches. Level of Evidence: Level IV. [ABSTRACT FROM AUTHOR]

Published
2024
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31. Acute Anterior Cruciate Ligament Reconstruction Performed Within 10 Days of Injury Does Not Increase Risk of Postoperative Arthrofibrosis: A Systematic Review and Meta-analysis.

Author

Aman, Zachary S., Blaber, Olivia K., R. McDermott, Emily, DeFoor, Mikalyn T., DePhillipo, Nicholas N., Dickens, Jonathan F., and Dekker, Travis J.

Subjects
RISK assessment, MEDICAL information storage & retrieval systems, CONTINUING education units, ACUTE diseases, ANTERIOR cruciate ligament surgery, ANTERIOR cruciate ligament injuries, QUALITATIVE research, ARTHROSCOPY, PROBABILITY theory, FUNCTIONAL status, TREATMENT effectiveness, META-analysis, QUANTITATIVE research, DESCRIPTIVE statistics, SURGICAL complications, FIBROSIS, SYSTEMATIC reviews, MEDLINE, ODDS ratio, REOPERATION, MEDICAL databases, INTRACLASS correlation, ONLINE information services, HEALTH outcome assessment, CONFIDENCE intervals, QUALITY assurance, COMPARATIVE studies, RANGE of motion of joints, DISEASE risk factors
Abstract

Background: The optimal timing of anterior cruciate ligament (ACL) reconstruction (ACLR) remains a controversial topic. Previous reviews have demonstrated that there are no differences between early and delayed ACLR; however, these studies have been limited by heterogeneous definitions of acute ACL injury. Purpose: To evaluate postoperative patient functional outcomes and risk for arthrofibrosis after acute arthroscopic ACLR performed ≤10 days after injury. Study Design: Systematic review; Level of evidence, 4. Methods: A systematic review was performed according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines using multiple medical databases. Inclusion criteria were studies that evaluated postoperative range of motion outcomes for patients undergoing ACLR ≤10 days after initial ACL injury. For included comparative studies comparing patient groups undergoing ACLR ≤10 days and patients undergoing "delayed" ACLR after ≥3 weeks of initial injury, quantitative analysis was performed to assess for differences in postoperative arthrofibrosis, reoperation rates, and patient-reported outcomes between groups. DerSimonian-Laird binary random-effects models were constructed to quantitatively describe the association between the ACLR time period and patient outcomes by generating effect estimates in the form of odds ratios with 95% CIs. Qualitative analysis was performed to describe variably reported patient outcomes and the risk of arthrofibrosis after ACLR for noncomparative studies. Results: Screening yielded 6 full-text articles with 448 patients who underwent ACLR (296 ACLR <10 days, 152 ACLR >3 weeks), with a pooled mean age of 28.1 years. For studies amenable to quantitative analysis, there were no significant differences between ACLR performed ≤10 days and ACLR performed at the 3-week point or after in terms of postoperative stiffness (3 studies; odds ratio, 1.27; P =.508), Tegner scores (2 studies; mean difference, –0.056; P =.155), or reoperation for stiffness (3 studies; odds ratio, 0.869; P =.462). The overall incidence of postoperative arthrofibrosis after 12 months of follow-up was 11 of 296 (3.7%) for ACLRs performed ≤10 days versus 6 of 152 (3.9%) for those performed at the 3-week point or after. Conclusion: ACLR performed ≤10 days after the inciting injury does not increase the risk of postoperative arthrofibrosis and demonstrates similar patient-reported outcomes compared with ACLR performed at the 3-week point or after. [ABSTRACT FROM AUTHOR]

Published
2024
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43. Contributors

Author

Adjei, Joshua, primary, Aibinder, William R., additional, Villa Albers, Marcio Bottene, additional, Altintas, Burak, additional, Anderson, Nicole, additional, Bach, Bernard Raymond, additional, Bokshan, Steven L., additional, Bottoni, Craig R., additional, Boykin, Robert E., additional, Branam, Barton R., additional, Brophy, Robert H., additional, Cagle, Paul J., additional, Camp, Christopher L., additional, Chan, Charles M., additional, Charles, Michael D., additional, Christian, David R., additional, Cognetti, Daniel J., additional, Cole, Brian J., additional, Cordasco, Frank A., additional, Cosgarea, Andrew J., additional, Croft, Stephen, additional, Cvetanovich, Gregory L., additional, DeBerardino, Thomas M., additional, DeFroda, Steven F., additional, Degen, Ryan, additional, Dempsey, Ian J., additional, DePhillipo, Nicholas N., additional, Dines, Joshua S., additional, Doerre, Teresa E., additional, Domos, Peter, additional, Dooley, Matthew S., additional, Douglass, Brenton W., additional, Edmonds, Eric W., additional, ElAttrache, Neal S., additional, Erickson, Brandon J., additional, Floren, Samuel A., additional, Fu, Freddie H., additional, Gandhi, Jigar S., additional, Ganley, Theodore J., additional, Garcia, Grant H., additional, Gause, Trenton, additional, Getgood, Alan, additional, Gomez-Hoyos, Juan, additional, Gomoll, Andreas, additional, Green, Daniel W., additional, Grimm, Nathan L., additional, Harner, Christopher D., additional, Henn, R. Frank, additional, Hill, J. Ryan, additional, Hughes, Jessica L., additional, Huleatt, Joel B., additional, Johnson, Darren L., additional, Kelly, Bryan T., additional, Kennedy, Mitchell I., additional, Kew, Michelle E., additional, Khoury, Anthony N., additional, Kocher, Mininder S., additional, Kreines, Alexander, additional, LaPrade, Robert F., additional, Leska, Tomasina M., additional, Limpisvasti, Orr, additional, Litchfield, Robert, additional, Liu, Joseph N., additional, Loeb, Alexander E., additional, London, Daniel A., additional, Malasitt, Pramote, additional, Marom, Niv, additional, Marshall, Nathan E., additional, Martin, Hal David, additional, Marx, Robert G., additional, Mazzocca, Augustus D., additional, McGough, Joshua D., additional, Melugin, Heath, additional, Meredith, Sean J., additional, Miller, Mark D., additional, Millett, Peter J., additional, Mlynarek, Ryan A., additional, Morrey, Mark E., additional, Nickoli, Michael S., additional, Ode, Gabriella, additional, Owens, Brett D., additional, Parsons, Bradford O., additional, Paschos, Nikolaos K., additional, Patel, Neeraj M., additional, Paxton, E. Scott, additional, Peebles, Liam A., additional, Provencher, Matthew T., additional, Raines, Benjamin Todd, additional, Redondo, Michael L., additional, Rhee, Peter C., additional, Rider, Danielle, additional, Roach, Christopher J., additional, Roessler, Philip P., additional, Romeo, Anthony A., additional, Roselaar, Naomi, additional, Rush, Jeremy K., additional, Schmitz, Matthew R., additional, Shea, Kevin G., additional, Sheean, Andrew J., additional, Sibilska, Aleksandra, additional, Stinson, Zach S., additional, Stone, Austin V., additional, Sullivan, Kayleigh, additional, Tanaka, Miho J., additional, Tennent, David J., additional, Thompson, Stephen R., additional, Tokish, John M., additional, Toth, Alison P., additional, Urchek, Ryan, additional, Uyeki, Colin L., additional, Vogel, Laura A., additional, Warth, Ryan J., additional, Waterman, Brian R., additional, Werner, Brian C., additional, Wixted, Colleen, additional, Xerogeanes, John, additional, Yanke, Adam B., additional, and Zhou, Liang, additional

Published
2019
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45. Anterior Referencing versus Posterior Referencing in Primary Total Knee Arthroplasty: A Meta-Analysis of Randomized Controlled Trials.

Author

Familiari, Filippo, Mercurio, Michele, Napoleone, Francesco, Galasso, Olimpio, Giuzio, Ermes, Simonetta, Roberto, Palco, Michelangelo, DePhillipo, Nicholas N., and Gasparini, Giorgio

Subjects
TOTAL knee replacement, RANDOMIZED controlled trials, RANGE of motion of joints
Abstract

(1) Background: The purpose of this study was to perform a systematic review and meta-analysis of studies comparing clinical and radiographic outcomes between anterior referencing (AR) and posterior referencing (PR) systems in total knee arthroplasty (TKA). (2) Methods: This study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. PubMed, MEDLINE, Scopus, and Cochrane Central databases were searched in August 2022. Data extracted for quantitative analysis included the Knee Society Score (KSS), the Western Ontario and McMaster University (WOMAC) index, knee ROM, posterior condylar offset (PCO), and the posterior condylar offset ratio (PCOR). The methodological quality of the included studies was assessed using the Modified Newcastle–Ottawa Quality Assessment. Randomized controlled trials were assessed with version 2 of the risk of bias tool (RoB2), recommended by the Cochrane Collaboration. (3) Results: For the meta-analysis, five comparative studies met the eligibility criteria. There were 584 patients in all, 294 of whom had AR TKA and 290 of whom had PR TKA. Three studies with 181 and 179 cases in the AR and PR groups, respectively, had reported preoperative KSS. A statistically significant difference was found favoring the PR group. (p = 0.01). The same cases' postoperative range of motion was documented, and a statistically significant difference was discovered in favor of the AR group. Postoperative PCO was described in four studies in 243 and 241 cases in the AR and PR TKA groups, respectively, and a statistically significant difference was found with a higher postoperative PCO in the PR group (p = 0.003). Postoperative PCOR was calculated in two studies in the same cases in the AR and PR TKA groups and a statistically significant difference was found with a higher postoperative PCOR in the PR group (p = 0.002). (4) Conclusion: Anterior referencing for TKA may result in improved knee ROM postoperatively, while posterior referencing may produce larger PCO and PCOR on postoperative imaging. However, no significant differences were noted in clinical outcomes between the AR and PR groups at final follow-up. [ABSTRACT FROM AUTHOR]

Published
2023
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