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329 results on '"DeMarco, Mari L."'

1. Effects of COVID-19 mRNA vaccination on HIV viremia and reservoir size

Author

Duncan, Maggie C., Omondi, F. Harrison, Kinloch, Natalie N., Lapointe, Hope R., Speckmaier, Sarah, Moran-Garcia, Nadia, Lawson, Tanya, DeMarco, Mari L., Simons, Janet, Holmes, Daniel T., Lowe, Christopher F., Bacani, Nic, Sereda, Paul, Barrios, Rolando, Harris, Marianne, Romney, Marc G., Montaner, Julio S.G., Brumme, Chanson J., Brockman, Mark A., and Brumme, Zabrina L.

Published
2024
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3. Applying the Alzheimer Disease ATN Diagnostic Framework in Atypical Dementia

Author

Funnell, Clark, Feldman, Howard H, Mackenzie, Ian RA, and DeMarco, Mari L

Subjects
Biological Psychology, Psychology, Alzheimer's Disease Related Dementias (ADRD), Lewy Body Dementia, Clinical Research, Brain Disorders, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Alzheimer's Disease, Prevention, Aging, Acquired Cognitive Impairment, Dementia, Neurosciences, Neurodegenerative, Detection, screening and diagnosis, 2.1 Biological and endogenous factors, Aetiology, 4.1 Discovery and preclinical testing of markers and technologies, Neurological, Aged, Alzheimer Disease, Amyloid beta-Peptides, Biomarkers, Diagnosis, Differential, Disease Progression, Humans, Lewy Body Disease, Male, tau Proteins, Alzheimer disease, amyloid, biomarkers, CSF, Lewy body dementia, neuropathology, synucleins, Clinical Sciences, Cognitive Sciences, Geriatrics, Clinical sciences, Biological psychology
Abstract

Cerebrospinal fluid (CSF) biomarkers amyloid-β and tau have been validated for the antemortem diagnosis of Alzheimer disease (AD) and are included in the AT(N) research framework for AD. Recently, an AT(N) CSF profile has been described for dementia with Lewy bodies (DLB), a disorder which is difficult to distinguish clinically from AD, particularly early in the disease course. Herein we describe a 71-year old male who presented with an atypical dementia syndrome including years of stability after an initial abrupt decline, marked visuospatial dysfunction, and relative sparing of memory. CSF biomarkers combined with the pattern of cognitive symptoms made AD unlikely and were consistent with DLB. This classification was confirmed clinically, with the emergence of classic DLB symptoms, and at postmortem pathologic examination. This case highlights the role for AD CSF biomarkers in facilitating earlier diagnosis of non-Alzheimer neurodegenerative dementias.

Published
2020

4. Homotypic fibrillization of TMEM106B across diverse neurodegenerative diseases

Author

Chang, Andrew, Xiang, Xinyu, Wang, Jing, Lee, Carolyn, Arakhamia, Tamta, Simjanoska, Marija, Wang, Chi, Carlomagno, Yari, Zhang, Guoan, Dhingra, Shikhar, Thierry, Manon, Perneel, Jolien, Heeman, Bavo, Forgrave, Lauren M., DeTure, Michael, DeMarco, Mari L., Cook, Casey N., Rademakers, Rosa, Dickson, Dennis W., Petrucelli, Leonard, Stowell, Michael H.B., Mackenzie, Ian R.A., and Fitzpatrick, Anthony W.P.

Published
2022
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5. Varoglutamstat: Inhibiting Glutaminyl Cyclase as a Novel Target of Therapy in Early Alzheimer's Disease.

Author

Feldman, Howard H., Messer, Karen, Qiu, Yuqi, Sabbagh, Marwan, Galasko, Douglas, Turner, R. Scott, Lopez, Oscar, Smith, Amanda, Durant, January, Lupo, Jody-Lynn, Revta, Carolyn, Balasubramanian, Archana, Kuehn-Wache, Kerstin, Wassmann, Tanja, Schell-Mader, Sylvia, Jacobs, Diane M., Salmon, David P., Léger, Gabriel, DeMarco, Mari L., and Weber, Frank

Subjects
ALZHEIMER'S disease, MILD cognitive impairment, COGNITIVE analysis, CEREBROSPINAL fluid, SMALL molecules
Abstract

Background: Varoglutamstat is a first-in-class, small molecule being investigated as a treatment for early Alzheimer's disease (AD). It is an inhibitor of glutaminyl cyclase (QC), the enzyme that post-translationally modifies amyloid-β (Aβ) peptides into a toxic form of pyroglutamate Aβ (pGlu-Aβ) and iso-QC which post-translationally modifies cytokine monocyte chemoattractant protein-1 (CCL2) into neuroinflammatory pGlu-CCL2. Early phase clinical trials identified dose margins for safety and tolerability of varoglutamstat and biomarker data supporting its potential for clinical efficacy in early AD. Objective: Present the scientific rationale of varoglutamstat in the treatment of early AD and the methodology of the VIVA-MIND (NCT03919162) trial, which uses a seamless phase 2A-2B design. Our review also includes other pharmacologic approaches to pGlu-Aβ. Methods: Phase 2A of the VIVA-MIND trial will determine the highest dose of varoglutamstat that is safe and well tolerated with sufficient plasma exposure and a calculated target occupancy. Continuous safety evaluation using a pre-defined safety stopping boundary will help determine the highest tolerated dose that will carry forward into phase 2B. An interim futility analysis of cognitive function and electroencephalogram changes will be conducted to inform the decision of whether to proceed with phase 2B. Phase 2B will assess the efficacy and longer-term safety of the optimal selected phase 2A dose through 72 weeks of treatment. Conclusions: Varoglutamstat provides a unique dual mechanism of action addressing multiple pathogenic contributors to the disease cascade. VIVA-MIND provides a novel and efficient trial design to establish its optimal dosing, safety, tolerability, and efficacy in early AD. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Antibody response durability following three-dose coronavirus disease 2019 vaccination in people with HIV receiving suppressive antiretroviral therapy

Author

Lapointe, Hope R., Mwimanzi, Francis, Cheung, Peter K., Sang, Yurou, Yaseen, Fatima, Speckmaier, Sarah, Barad, Evan, Moran-Garcia, Nadia, Datwani, Sneha, Duncan, Maggie C., Kalikawe, Rebecca, Ennis, Siobhan, Young, Landon, Ganase, Bruce, Omondi, F. Harrison, Umviligihozo, Gisele, Dong, Winnie, Toy, Junine, Sereda, Paul, Burns, Laura, Costiniuk, Cecilia T., Cooper, Curtis, Anis, Aslam H., Leung, Victor, Holmes, Daniel, DeMarco, Mari L., Simons, Janet, Hedgcock, Malcolm, Prystajecky, Natalie, Lowe, Christopher F., Romney, Marc G., Barrios, Rolando, Guillemi, Silvia, Brumme, Chanson J., Montaner, Julio S.G., Hull, Mark, Harris, Marianne, Niikura, Masahiro, Brockman, Mark A., and Brumme, Zabrina L.

Published
2023
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9. Humoral immune responses to COVID-19 vaccination in people living with HIV receiving suppressive antiretroviral therapy

Author

Brumme, Zabrina L., Mwimanzi, Francis, Lapointe, Hope R., Cheung, Peter K., Sang, Yurou, Duncan, Maggie C., Yaseen, Fatima, Agafitei, Olga, Ennis, Siobhan, Ng, Kurtis, Basra, Simran, Lim, Li Yi, Kalikawe, Rebecca, Speckmaier, Sarah, Moran-Garcia, Nadia, Young, Landon, Ali, Hesham, Ganase, Bruce, Umviligihozo, Gisele, Harrison Omondi, F., Atkinson, Kieran, Sudderuddin, Hanwei, Toy, Junine, Sereda, Paul, Burns, Laura, Costiniuk, Cecilia T., Cooper, Curtis, Anis, Aslam H., Leung, Victor, Holmes, Daniel, DeMarco, Mari L., Simons, Janet, Hedgcock, Malcolm, Romney, Marc G., Barrios, Rolando, Guillemi, Silvia, Brumme, Chanson J., Pantophlet, Ralph, Montaner, Julio S. G., Niikura, Masahiro, Harris, Marianne, Hull, Mark, and Brockman, Mark A.

Published
2022
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10. T-Cell Responses to COVID-19 Vaccines and Breakthrough Infection in People Living with HIV Receiving Antiretroviral Therapy

Author

Datwani, Sneha, primary, Kalikawe, Rebecca, additional, Waterworth, Rachel, additional, Mwimanzi, Francis M., additional, Liang, Richard, additional, Sang, Yurou, additional, Lapointe, Hope R., additional, Cheung, Peter K., additional, Omondi, Fredrick Harrison, additional, Duncan, Maggie C., additional, Barad, Evan, additional, Speckmaier, Sarah, additional, Moran-Garcia, Nadia, additional, DeMarco, Mari L., additional, Hedgcock, Malcolm, additional, Costiniuk, Cecilia T., additional, Hull, Mark, additional, Harris, Marianne, additional, Romney, Marc G., additional, Montaner, Julio S. G., additional, Brumme, Zabrina L., additional, and Brockman, Mark A., additional

Published
2024
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21. Clinical value of Alzheimer's disease biomarker testing.

Author

Patel, Khushbu J., Yang, David, Best, John R., Chambers, Colleen, Lee, Philip E., Henri‐Bhargava, Alexandre, Funnell, Clark R., Foti, Dean J., Pettersen, Jacqueline A., Feldman, Howard H., Nygaard, Haakon B., Hsiung, Ging‐Yuek R., and DeMarco, Mari L.

Subjects
ALZHEIMER'S disease, BIOMARKERS, FAMILY counseling, NEUROPSYCHOLOGICAL tests, MEDICAL care
Abstract

INTRODUCTION: In the Investigating the Impact of Alzheimer's Disease Diagnostics in British Columbia (IMPACT‐AD BC) study, we aimed to understand how Alzheimer's disease (AD) cerebrospinal fluid (CSF) biomarker testing—used in medical care—impacted medical decision‐making (medical utility), personal decision‐making (personal utility), and health system economics. METHODS: The study was designed as an observational, longitudinal cohort study. A total of 149 patients were enrolled between February 2019 and July 2021. Patients referred to memory clinics were approached to participate if their dementia specialist ordered AD CSF biomarker testing as part of their routine medical care, and the clinical scenario met the appropriate use criteria for lumbar puncture and AD CSF biomarker testing. For the medical utility pillar, detailed clinical management plans were collected via physician questionnaires pre‐ and post‐biomarker disclosure. RESULTS: Patients with completed management questionnaires (n = 142) had a median age of 64 (interquartile range: 59–69) years, 48% were female, and 60% had CSF biomarker profiles on the AD continuum. Clinical management changed in 89.4% of cases. AD biomarker testing was associated with decreased need for other diagnostic procedures, including brain imaging (–52.0%) and detailed neuropsychological assessments (–63.2%), increased referrals and counseling (57.0%), and guided AD‐related drug prescriptions (+88.4% and –50.0% in biomarker‐positive and ‐negative cases, respectively). DISCUSSION: AD biomarker testing was associated with significant and positive changes in clinical management, including decreased health care resource use, therapy optimization, and increased patient and family member counseling. While certain changes in management were linked to the AD biomarker profile (e.g., referral to clinical trials), the majority of changes were independent of baseline clinical presentation and level of cognitive impairment, demonstrating a broad value for AD biomarker testing in individuals meeting the appropriate use criteria for testing. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Personal value of Alzheimer's disease biomarker testing and result disclosure from the patient and care partner perspective.

Author

Patel, Khushbu J., Yang, David, Feldman, Howard H., Hsiung, Ging‐Yuek R., Nygaard, Haakon B., Best, John R., Dwosh, Emily, Robillard, Julie M., and DeMarco, Mari L.

Subjects
ALZHEIMER'S disease, DISCLOSURE, BIOMARKERS, PATIENT care, CEREBROSPINAL fluid
Abstract

INTRODUCTION: We described patients' and care partners' experiences with Alzheimer's disease (AD) cerebrospinal fluid (CSF) biomarker testing and result disclosure in routine care. METHODS: IMPACT‐AD BC is an observational study of clinic patients who underwent AD CSF biomarker testing as part of their routine medical care (n = 142). In the personal utility arm of the study, semi‐structured phone interviews were conducted with a subset of patients (n = 34), and separately with their care partners (n = 31). Post‐disclosure interviews were conducted ∼1 month and ∼6 months after biomarker result disclosure and investigated the patients' decision‐making process around testing, impact of receiving results, wellness and lifestyle changes, and future planning. RESULTS: A majority of patients (90%) rated their decision to undergo testing as "easy." Post‐disclosure, the majority (82%) reported overall positive feelings from having greater certainty and the ability to plan ahead, and results spurred them to adopt/continue healthy behaviors such as exercise (84%) and cognitive activities (54%). Care partners expressed relief from having more diagnostic certainty, increased appreciation of future caregiving responsibilities, and a desire to connect with support resources. DISCUSSION: Perspectives of persons with lived experience in dementia provide new insight into the value of biomarker testing and should be included as part of evidence‐guided considerations for pre‐test counseling and result disclosure. Moreover, study findings identify an interval when patients and care partners are highly receptive to positive lifestyle and medical interventions. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Effects of COVID-19 mRNA vaccination on HIV viremia and reservoir size

Author

Duncan, Maggie C., primary, Omondi, F. Harrison, additional, Kinloch, Natalie N., additional, Lapointe, Hope R., additional, Speckmaier, Sarah, additional, Moran-Garcia, Nadia, additional, Lawson, Tanya, additional, DeMarco, Mari L., additional, Simons, Janet, additional, Holmes, Daniel T., additional, Lowe, Christopher F., additional, Bacani, Nic, additional, Sereda, Paul, additional, Barrios, Rolando, additional, Harris, Marianne, additional, Romney, Marc G., additional, Montaner, Julio S.G., additional, Brumme, Chanson J., additional, Brockman, Mark A., additional, and Brumme, Zabrina L., additional

Published
2023
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28. Dynamics of T-cell responses following COVID-19 mRNA vaccination and breakthrough infection in older adults

Author

Datwani, Sneha, primary, Kalikawe, Rebecca, additional, Mwimanzi, Francis, additional, Speckmaier, Sarah, additional, Liang, Richard, additional, Sang, Yurou, additional, Waterworth, Rachel, additional, Yaseen, Fatima, additional, Lapointe, Hope R., additional, Barad, Evan, additional, DeMarco, Mari L., additional, Holmes, Daniel T., additional, Simons, Janet, additional, Montaner, Julio S.G., additional, Romney, Marc G., additional, Brumme, Zabrina L., additional, and Brockman, Mark A., additional

Published
2023
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32. Truncated TDP‐43 proteoforms diagnostic of frontotemporal dementia with TDP‐43 pathology.

Author

Forgrave, Lauren M., Moon, Kyung‐Mee, Hamden, Jordan E., Li, Yun, Lu, Phoebe, Foster, Leonard J., Mackenzie, Ian R. A., and DeMarco, Mari L.

Abstract

INTRODUCTION: Biomarkers of TDP‐43 pathology are needed to distinguish frontotemporal lobar degeneration with TDP‐43 pathology (FTLD‐TDP) from phenotypically related disorders. While normal physiological TDP‐43 is not a promising biomarker, low‐resolution techniques have suggested truncated forms of TDP‐43 may be specific to TDP‐43 pathology. To advance biomarker efforts for FTLD‐TDP, we employed a high‐resolution structural technique to characterize TDP‐43 post‐translational modifications in FTLD‐TDP. METHODS: High‐resolution mass spectrometry was used to characterize TDP‐43 proteoforms in brain tissue from FTLD‐TDP, non‐TDP‐43 dementias and neuropathologically unaffected cases. Findings were then verified in a larger cohort of FTLD‐TDP and non‐TDP‐43 dementias via targeted quantitative mass spectrometry. RESULTS: In the discovery phase, truncated TDP‐43 identified FTLD‐TDP with 85% sensitivity and 100% specificity. The verification phase revealed similar findings, with 83% sensitivity and 89% specificity. DISCUSSION: The concentration of truncated TDP‐43 proteoforms—in particular, in vivo generated C‐terminal fragments—have high diagnostic accuracy for FTLD‐TDP. Highlights: Discovery: Truncated TDP‐43 differentiates FTLD‐TDP from related dementias.Verification: Truncated TDP‐43 concentration has high accuracy for FTLD‐TDP.TDP‐43 proteoforms <28 kDa have highest discriminatory power for TDP‐43 pathology. [ABSTRACT FROM AUTHOR]

Published
2024
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34. Impact of Age and Severe Acute Respiratory Syndrome Coronavirus 2 Breakthrough Infection on Humoral Immune Responses After Three Doses of Coronavirus Disease 2019 mRNA Vaccine

Author

Mwimanzi, Francis, primary, Lapointe, Hope R, additional, Cheung, Peter K, additional, Sang, Yurou, additional, Yaseen, Fatima, additional, Kalikawe, Rebecca, additional, Datwani, Sneha, additional, Burns, Laura, additional, Young, Landon, additional, Leung, Victor, additional, Ennis, Siobhan, additional, Brumme, Chanson J, additional, Montaner, Julio S G, additional, Dong, Winnie, additional, Prystajecky, Natalie, additional, Lowe, Christopher F, additional, DeMarco, Mari L, additional, Holmes, Daniel T, additional, Simons, Janet, additional, Niikura, Masahiro, additional, Romney, Marc G, additional, Brumme, Zabrina L, additional, and Brockman, Mark A, additional

Published
2023
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36. Antibody response durability following three-dose COVID-19 vaccination in people with HIV receiving suppressive ART

Author

Lapointe, Hope R., primary, Mwimanzi, Francis, additional, Cheung, Peter K., additional, Sang, Yurou, additional, Yaseen, Fatima, additional, Speckmaier, Sarah, additional, Barad, Evan, additional, Moran-Garcia, Nadia, additional, Datwani, Sneha, additional, Duncan, Maggie C., additional, Kalikawe, Rebecca, additional, Ennis, Siobhan, additional, Young, Landon, additional, Ganase, Bruce, additional, Omondi, F. Harrison, additional, Umviligihozo, Gisele, additional, Dong, Winnie, additional, Toy, Junine, additional, Sereda, Paul, additional, Burns, Laura, additional, Costiniuk, Cecilia T., additional, Cooper, Curtis, additional, Anis, Aslam H., additional, Leung, Victor, additional, Holmes, Daniel, additional, Demarco, Mari L., additional, Simons, Janet, additional, Hedgcock, Malcolm, additional, Prystajecky, Natalie, additional, Lowe, Christopher F., additional, Romney, Marc G., additional, Barrios, Rolando, additional, Guillemi, Silvia, additional, Brumme, Chanson J., additional, Montaner, Julio S.G., additional, Hull, Mark, additional, Harris, Marianne, additional, Niikura, Masahiro, additional, Brockman, Mark A., additional, and Brumme, Zabrina L., additional

Published
2022
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39. Serial infection with SARS-CoV-2 Omicron BA.1 and BA.2 following three-dose COVID-19 vaccination

Author

Lapointe, Hope R., primary, Mwimanzi, Francis, additional, Cheung, Peter K., additional, Sang, Yurou, additional, Yaseen, Fatima, additional, Kalikawe, Rebecca, additional, Datwani, Sneha, additional, Waterworth, Rachel, additional, Umviligihozo, Gisele, additional, Ennis, Siobhan, additional, Young, Landon, additional, Dong, Winnie, additional, Kirkby, Don, additional, Burns, Laura, additional, Leung, Victor, additional, Holmes, Daniel T., additional, DeMarco, Mari L., additional, Simons, Janet, additional, Matic, Nancy, additional, Montaner, Julio S.G., additional, Brumme, Chanson J., additional, Prystajecky, Natalie, additional, Niikura, Masahiro, additional, Lowe, Christopher F., additional, Romney, Marc G., additional, Brockman, Mark A., additional, and Brumme, Zabrina L., additional

Published
2022
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40. Impact of age and SARS-CoV-2 breakthrough infection on humoral immune responses after three doses of COVID-19 mRNA vaccine

Author

Mwimanzi, Francis, primary, Lapointe, Hope R., additional, Cheung, Peter K., additional, Sang, Yurou, additional, Yaseen, Fatima, additional, Kalikawe, Rebecca, additional, Datwani, Sneha, additional, Burns, Laura, additional, Young, Landon, additional, Leung, Victor, additional, Ennis, Siobhan, additional, Brumme, Chanson J., additional, Montaner, Julio S.G., additional, Dong, Winnie, additional, Prystajecky, Natalie, additional, Lowe, Christopher F., additional, DeMarco, Mari L., additional, Holmes, Daniel T., additional, Simons, Janet, additional, Niikura, Masahiro, additional, Romney, Marc G., additional, Brumme, Zabrina L., additional, and Brockman, Mark A., additional

Published
2022
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42. People With Human Immunodeficiency Virus Receiving Suppressive Antiretroviral Therapy Show Typical Antibody Durability After Dual Coronavirus Disease 2019 Vaccination and Strong Third Dose Responses

Author

Lapointe, Hope R, primary, Mwimanzi, Francis, additional, Cheung, Peter K, additional, Sang, Yurou, additional, Yaseen, Fatima, additional, Umviligihozo, Gisele, additional, Kalikawe, Rebecca, additional, Speckmaier, Sarah, additional, Moran-Garcia, Nadia, additional, Datwani, Sneha, additional, Duncan, Maggie C, additional, Agafitei, Olga, additional, Ennis, Siobhan, additional, Young, Landon, additional, Ali, Hesham, additional, Ganase, Bruce, additional, Omondi, F Harrison, additional, Dong, Winnie, additional, Toy, Junine, additional, Sereda, Paul, additional, Burns, Laura, additional, Costiniuk, Cecilia T, additional, Cooper, Curtis, additional, Anis, Aslam H, additional, Leung, Victor, additional, Holmes, Daniel T, additional, DeMarco, Mari L, additional, Simons, Janet, additional, Hedgcock, Malcolm, additional, Prystajecky, Natalie, additional, Lowe, Christopher F, additional, Pantophlet, Ralph, additional, Romney, Marc G, additional, Barrios, Rolando, additional, Guillemi, Silvia, additional, Brumme, Chanson J, additional, Montaner, Julio S G, additional, Hull, Mark, additional, Harris, Marianne, additional, Niikura, Masahiro, additional, Brockman, Mark A, additional, and Brumme, Zabrina L, additional

Published
2022
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44. Older Adults Mount Less Durable Humoral Responses to Two Doses of COVID-19 mRNA Vaccine but Strong Initial Responses to a Third Dose

Author

Mwimanzi, Francis, primary, Lapointe, Hope R, additional, Cheung, Peter K, additional, Sang, Yurou, additional, Yaseen, Fatima, additional, Umviligihozo, Gisele, additional, Kalikawe, Rebecca, additional, Datwani, Sneha, additional, Omondi, F Harrison, additional, Burns, Laura, additional, Young, Landon, additional, Leung, Victor, additional, Agafitei, Olga, additional, Ennis, Siobhan, additional, Dong, Winnie, additional, Basra, Simran, additional, Lim, Li Yi, additional, Ng, Kurtis, additional, Pantophlet, Ralph, additional, Brumme, Chanson J, additional, Montaner, Julio S G, additional, Prystajecky, Natalie, additional, Lowe, Christopher F, additional, DeMarco, Mari L, additional, Holmes, Daniel T, additional, Simons, Janet, additional, Niikura, Masahiro, additional, Romney, Marc G, additional, Brumme, Zabrina L, additional, and Brockman, Mark A, additional

Published
2022
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45. Geriatric dementia care at Ontario Shores: A new model of care

Author

Viau, Katelynn, Yaddaden, Amel, Lussier, Maxime, Bier, Nathalie, Earle, Julie, Duff-Woskosky, Andra, Bartfay, Wally, Desai, Chaitali, Zavitz, Karen, Horsburgh, Sheri, Gamble, Brenda, Lee, Linda, Hillier, Loretta M., Patel, Tejal, Molnar, Frank, Clarke, Jo-Anne, Borrie, Michael, Cammer, Allison, Morgan, Debra, Whiting, Susan, de Vos, Maya, Henri-Bhargava, Alexandre, Votova, Kristine, Delmar, Paul, Kerchner, Geoffrey A, Wang, Guoqiao, Bateman, Randall, Klein, Gregory, Andjelkovic, Mirjana, Abi-Saab, Danielle, Bullain, Szofia, Montoya, Alonso, Fontoura, Paulo, Doody, Rachelle, Tai, Elaine, Harvey, David, Hofmann, Carsten, Ristic, Smiljana, Rehal, Sunita, Voyle, Nicola, Baudler, Monika, Verreault, Phylicia, Rousseau, François, Keller, Evelyn, Simard, Alexandra, Azouaou, Nassima, Jarboui, Manel, Talleria, Lorraine, Duguay, Johanne, Mérette, Chantale, Labbé, Annie, de Arco, Rossana Peredo Nunez, Yous, Marie-Lee, Ploeg, Jenny, Kaasalainen, Sharon, Martin, Lori Schindel, Palumbo, Mary Val, Rambur, Betty, McKenna, Lori, Voyer, Philippe, Allaire, Émilie, Li, Bing, Thaut, Michael, Yogaparan, Thirumagal, Shanmuganathan, Thirunathan, Vickneswaran, Anicha, Sriharan, Sruthy, DeMarco, Mari L., Hsiung, Ging-Yuek Robin, Best, John R., Chertkow, Howard, Gauthier, Serge, Karlawish, Jason, Feldman, Howard, Spaner, Caroline, Christie, Brian, Musteata, Stela, Gawryluk, Jodie, Hofer, Scott, Henri-Bhargava, Alex, Kenny, Rebecca, Elliot, Valerie, Kosteniuk, Julie, Chow, Amanda Froehlich, Bayly, Melanie, O’Connell, Megan E., Kortzman, August, O’Connell, Megan, Kirk, Andrew, Conn, David, Sokoloff, Lisa, Feldman, Sid, Chau, James, Moser, Andrea, Lingum, Navena, Gingrich, Shaen, Shaikh, Salma, Rabheru, Kiran, Cassidy, Keri-Leigh, Checkland, Claire, Parsons, Daria, Massie, Ariane S., Mitchell, Julie Spence, Aksenchuk, Sophia, Lindsay, Barbara, Howard, Maria, Shaw, Courtney, Armitage, Gerrard, Capstick, Andrea, McNeil, Heather, Holyoke, Paul, Vines, Chanile, Giosa, Justine, Khan, Bilal, Shultz, Mary, BEAUCHET, Olivier, Sekhon, Harmehr, Allali, Gilles, Montembeault, Maxime, Brodeur, Catherine, Macoir, Joël, Maxwell, Colleen, Maclagan, Laura, Campitelli, Michael, Yao, Shenzhen, Dharma, Christoffer, Sherin, Tracey, Hogan, David, Bronskill, Susan, Ivo, Jessica, Faisal, Sadaf, McDougall, Aidan, Bauer, Jillian, Pritchard, Sarah, Chang, Feng, Mehta, Deval, Syed, Ali, Carter, Caitlin, Sharma, Shaambhavi, Nagge, Jeff, Naglie, Gary, Stasiulis, Elaine, Yamin, Stephanie, Vrkljan, Brenda, Tuokko, Holly, Sanford, Sarah, Porter, Michelle, Polgar, Jan, Myers, Anita, Moorhouse, Paige, Mazer, Barbara, Marshall, Shawn, Gélinas, Isabelle, Crizzle, Alexander, Byszewski, Anna, Belchior, Patricia, Bédard, Michel, Rapoport, Mark, Minish, Duane, Yetman, Linda, Stephenson, Margaret, McCloskey, Rose, Agbaku, Mansa, Jarrett, Pamela, Cavanagh, Jennifer, Loncar, Adele, Demers, Vickie, Gobessi, Linda, Lodha, Vinay, Scerbe, Andrea, Astell, Arlene, DesRoches, Andrea, Panyavin, Ivan, Feltz, Nick, Wittich, Walter, Aubin, Gabrielle, Hogan, Mariah, Swaminathan, Swathi, Altschuler, Aviva, Murphy, Kelly, Guthrie, Dawn, Williams, Nicole, Campos, Jennifer, Mick, Paul, Orange, Joseph B., Pichora-Fuller, M. Kathleen, Savundranayagam, Marie Y., Phillips, Natalie A., Giroud, Nathalie, Pichora-Fuller, Kathy, Al-Yawer, Faisal, Rehan, Sana, Phillips, Natalie, Beauchet, Olivier, Niculescu, Iulia, Iaboni, Andrea, Quirt, Hannah, Penko, Marion, Tsokas, Mario, Marshall, Cecelia, Flint, Alastair, McGilton, Katherine, O’Connell, Megan E, Stewart, Norma J, Seitz, Dallas, Daku, Jean, Hack, Tracy, Hoium, Faye, Kennett-Russill, Deb, Sauter, Kristen, Holley, Joanna, Wimhurst, Christine, Katchaluba, Janet, Mitchell, Debbie, Severina, Elmira, Dallaire-Théroux, Caroline, Saikali, Stéphan, Duchesne, Simon, Sivananthan, Saskia, Mirza, Saira, Saeed, Usman, Knight, Jo, Ramirez, Joel, Stuss, Donald, Yu, Di, Swardfager, Walter, Keith, Julia, Nestor, Sean, Black, Sandra, Masellis, Mario, Joyal, Marilyne, Kotz, Sonja A., Lenglos, Christophe, Renauld, Emmanuelle, Wilson, Maximiliano A., Fecteau, Shirley, Appel, Lora, Kisonas, Erika, Appel, Eva, Bartlett, Deanna, Klein, Jennifer, Rosenberg, Jarred, Smith, Christopher, Ali, Suad, Narang, Tanya, Wiseman, Micaela, Ein, Natalie, Orchanian-Cheff, Ani, Rylett, Jane, Hogan, David B., Rockwood, Kenneth, Dixon, Roger, Sun, Winnie, Hawkins, Stacey A., Awde, Carolee, Kay, Kelly, Huntsbarger, Deana, Ferrier, Erin, Sourial, Nadia, Arsenault-Lapierre, Genevieve, McAiney, Carrie, Vedel, Isabelle, Ingram, K. Jennifer, Frank, Andrew, Sabra, Iman, Wallace, Bruce, Breau, Michael, Sweet, Lisa, Goubran, Rafiq, Knoefel, Frank, Goubran, Rafik, Stroulia, Eleni, Ault, Laura, Kecskemet, Judith, Guseva, Elena, Lungu, Ovidiu, Goldman, Sondra, Wilchesky, Machelle, Johri, Fozia, Turner, Angelese, Lavoie, Monica, Tang-Wai, David, Leonard, Carol, Graham, Naida L., Rochon, Elizabeth, Middleton, Laura, Herrmann, Nathan, Oh, Paul, Regan, Kayla, Bechard, Lauren, Lanctôt, Krista, Freeman, Shannon, Pettersen, Jacqueline, Tomasone, Jennifer, Dupuis, Sherry, Giangregorio, Lora, Ferris, Rebecca, Stultz, Tim, Mallard, Kirsten, Campbell, Elaine, Chatterjee, Atri, Mackenzie, Ian, Reinshagen, Veronica Hirsh, Ducharme, Blake, Mousavi, Ali, Gill, Sascha, Mouches, Pauline, Wang, Meng, Rajasheskar, Deepthi, MacMaster, Frank, Forkert, Nils, Smith, Eric, Ismail, Zahinoor, Varatharajah, Breni, Camicioli, Richard, Gee, Myrlene, Zwiers, Angela, Sekhon, Ramnik, Charlton, Anna, Arsenault-Lapierre, Geneviève, Ingram, Jennifer, Hawkins, Stacey, Mousavi, SeyedAli, Mackenzie, Ian R. A., Hirsh-Reinshagen, Veronica, Hsiung, Ging-Yuek. R., Gillingham, Susan M.E., Anderson, Nicole D., Alain, Claude, Georgievski, Georgi, Alfaro, Leonardo, McClenaghan, Meridith, Soares, Daniela, Matheson, Maureen, Stanoulis, Krisanne, Boyle, Daniel, Chau, Linh, Pelc, Jordan, Snash, Nadia, Byrne, Joanne, Elalouf, Karine, Alfaro, Andrea Urqueta, Johnson, Aaron, Marinier, Julie-Andrée, Kehayia, Eva, Gagné, Jean-Pierre, Murphy, Caitlin, Ellen, Ruth, Flowers, Brandi, Boulton, Karen Lee, Subotic, Arsenije, McCreary, Cheryl R., Nguyen, Amanda, Saad, Feryal, Alvarez, Ana, Beaudin, Andrew E, Pike, Bruce, Smith, Eric E, Hu, Sophie, Patten, Scott, Fick, Gordon, Sapkota, Shraddha, Mirza, Saira Saeed, Scott, Christopher J., Stuss, Donald T., Black, Sandra E., Le Blanc, Gabriella, Ducharme, Simon, Meilleur-Durand, Synthia, Lévesque, Marianne, St-Onge, Frédéric, Cunnane, Stephen, Villeneuve, Sylvia, Callahan, Brandy, Laforce, Robert, Cetin-Sahin, Deniz, Cummings, Greta G., Schuster, Tibor, Karanofsky, Mark, De Jesus, Belmir J., Cassani, Raymundo, Cecchi, Marco, Fadem, K. C., McGeown, William J., Falk, Tiago H., Chu, Charlene, Zdaniuk, Natalia, Wang, Rosalie, Ouellet, Marie-Christine, Cassivi-Joncas, Alison, Godard-Sebillotte, Claire, Rochette, Louis, Pelletier, Eric, Strumpf, Erin, Margo-Dermer, Eva, Silver, Hilah, Vafaei, Rod, Fok, Alice C, Hsiung, Ging-Yuek R., Ursenbach, Jake, Bethell, Jennifer, Neuman, Mark D, Bateman, Brian T, Hill, Andrea, Wunsch, Hannah, Ritchie, Kim, Cramm, Heidi, Aiken, Alice, Donnelly, Catherine, Goldie, Katie, Delara, Mahin, Ozzoude, Miracle, Varriano, Brenda, McLaughlin, Paula, Troyer, Angela, Bartha, Robert, Symons, Sean, Kwan, Donna, Tan, Brian, Swartz, Richard H., Saposnik, Gustavo, Tartaglia, Maria C., Ahuja, Manan, Siddhpuria, Shailee, Gormley, Jessica, Reppas, Christina, Wong, Eric, Lee, Justin, Patterson, Christopher, Walker, Jennifer, Warry, Wayne, Blind, Melissa, Allaby, Cheryl, Pitawanakwat, Karen, Zhao, Yantao, Lemieux, Andrine, Jacklin, Kristen, Crowshoe, Lindsay, Boehme, Gail, McKenna, Betty, Boyling, Elaine, Webkamigad, Sharlene, Bigeagle, Louise, Akan, Nicole, Wallace, Lindsay, Theou, Olga, Bennett, David, Darvesh, Sultan, Kirkland, Susan, Fisk, John, Andrew, Melissa, Cullen, Stephanie, Carroll, Susan, Mahon, Joel, Sarquis-Adamson, Yanina, Montero-Odasso, Manuel, Sharma, Nabina, Beaton, Derek, Roberts, Angela, Munoz, Doug, Swartz, Richard, Breen, David, Lang, Anthony, Fischer, COrrine, Fischer, Corrine, Kumar, Sanjeeve, Freedman, Morris, Finger, Elizabeth, Zinman, Lorne, Grimes, David A., Sunderland, Kelly M., Binns, Malcolm A., Strother, Stephen C., Mandzia, Jennifer, Orange, JB, Tartaglia, Carmela, El Shatshat, Amna, Rao, Praveen P.N., Teves, Julia, Bodkin, R Jack, Ho, Joanne M-W, Mehdizadeh, Sina, Dolatabadi, Elham, Ng, Kimberley-Dale, Arora, Twinkle, Jizmejian, Melody, Mansfield, Avril, Taati, Babak, Levy, Jake, Savard, Melissa, Pascoal, Tharick, Soucy, Jean-Paul, Rosa-Neto, Pedro, Martins, Felicia, Waller, Shannon, Flora, Parminder, Morland, Chris, Donovan, Steve, Fels, Deborah, Desai, Shital, Boger, Jennifer, Shashtri, Karan, Persaud, Deanna, Marashi, Sheida, Nedlund, Ann-Charlotte, Mäki-Petäjä-Leinonen, Anna, Nygård, Louise, Issakainen, Mervi, ryd, Charlotta, Pan, Yuhan, Joddrell, Phil, Dove, Erica, Owens, Hollis, Park, Elly, Liu, Lili, Kaufman, David, Simonian, Natalie, Chen, Ying, Sunderland, Kelly, Fraser, Julia, Swartz, Rick, Strother, Stephen, Legrand, Diego, Roberge, Pasquale, Vanasse, Alain, Bocti, Christian, Pirrie, Lorraine, Gray, Carolyn Steele, Nippak, Pria, Coughlan, Dave, Teselink, Johannes, Hermann, Nathan, Rasquinha, Fawn, Lanctot, Krista, Webber, Jodi, Woo, Kevin, Chamoun, Elicia, Coulombe, Valérie, Sellami, Leila, Paquette-Raynard, Emmanuelle, Gardner, Sandra, van Zon, Lorraine, Moy, Sally, Sidrak, Mariam, Sternhill, Janis, Feldman, Sidney, Karuza, Jurgis, Berall, Anna, Thomas, Neil, Mattek, Nora, Riley, Thomas, Reynolds, Christina, Marcoe, Jennifer, Sharma, Nicole, Kaye, Jeffrey, Jagtap, Shreya, Rotenberg, Shlomit, Vandermorris, Susan, Anderson, ND, Dawson, DR, Chater, Catherine, Soor, Jaspreet, Ji, Xiang, Koo, Morgan, Compagnone, Jordana, Kertes, Peter, Juby, Angela, Mager, Diana, Davis, Christopher, Jay, David, Blackburn, Toni, Brocks, Dion, Lee, Hyunwoo, Wiggermann, Vanessa, Rauscher, Alexander, Lam, Kevin, Tam, Roger, Popuri, Karteek, Beg, Mirza Faisal, Jacova, Claudia, Sossi, Vesna, Bindra, Jessica, Bouvier, Liziane, Monetta, Laura, Vitali, Paolo, Martel-Sauvageau, Vincent, Godin, Judith, McNeil, Shelly, McElhaney, Janet, Laughton, Thomas, Ho, Joanne, Tung, Jennifer, Dubé, Joseph B., Lin, Tianzhen, Best, Sarah, Truemner, Julia, Sargeant, Patricia L., Borrie, Michael J., Fogarty, Jennifer, Bassi, Nimi, Di Prospero, Cynthia, Whitehead, Victor, Pilon, Randi, Wong, Timothy, Elhayek, Nada, Dasgupta, Monidipa, Davis, Daniel, ORegan, Niamh, Kröger, Edeltraut, Furrer, Daniela, Wilcheski, Machelle, Morin, Michèle, Carmichael, Pierre-Hugues, Champoux, Nathalie, Monette, Johanne, Giguère, Anik, Aubin, Michèle, Durand, Pierre, Whiteside, Jena, Mele, Bria, Merrikh, Daria, Goodarzi, Zahra, Seary, Judith Anne, Bulley, Heather, Diciacca, Allison, Esseltine, Julia, Gaiger, Erin, Jankovic, Ivana, Mackenzie, Stephanie, McBride, Meghan, Knopp-Sihota, Jennifer A., Hoben, Mathias, Poss, Jeffrey W., Rachor, Geoffrey S., Estabrooks, Carole A., and Iroanyah, Ngozi

Subjects
Abstracts: Posters
Published
2020

47. People with HIV receiving suppressive antiretroviral therapy show typical antibody durability after dual COVID-19 vaccination, and strong third dose responses

Author

Lapointe, Hope R., primary, Mwimanzi, Francis, additional, Cheung, Peter K., additional, Sang, Yurou, additional, Yaseen, Fatima, additional, Umviligihozo, Gisele, additional, Kalikawe, Rebecca, additional, Speckmaier, Sarah, additional, Moran-Garcia, Nadia, additional, Datwani, Sneha, additional, Duncan, Maggie C., additional, Agafitei, Olga, additional, Ennis, Siobhan, additional, Young, Landon, additional, Ali, Hesham, additional, Ganase, Bruce, additional, Omondi, F. Harrison, additional, Dong, Winnie, additional, Toy, Junine, additional, Sereda, Paul, additional, Burns, Laura, additional, Costiniuk, Cecilia T., additional, Cooper, Curtis, additional, Anis, Aslam H., additional, Leung, Victor, additional, Holmes, Daniel, additional, DeMarco, Mari L., additional, Simons, Janet, additional, Hedgcock, Malcolm, additional, Prystajecky, Natalie, additional, Lowe, Christopher F., additional, Pantophlet, Ralph, additional, Romney, Marc G., additional, Barrios, Rolando, additional, Guillemi, Silvia, additional, Brumme, Chanson J., additional, Montaner, Julio S.G., additional, Hull, Mark, additional, Harris, Marianne, additional, Niikura, Masahiro, additional, Brockman, Mark A., additional, and Brumme, Zabrina L., additional

Published
2022
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49. Clinical reporting following the quantification of cerebrospinal fluid biomarkers in Alzheimer's disease: An international overview

Author

Delaby, Constance, primary, Teunissen, Charlotte E., additional, Blennow, Kaj, additional, Alcolea, Daniel, additional, Arisi, Ivan, additional, Amar, Elodie Bouaziz, additional, Beaume, Anne, additional, Bedel, Aurélie, additional, Bellomo, Giovanni, additional, Bigot‐Corbel, Edith, additional, Bjerke, Maria, additional, Blanc‐Quintin, Marie‐Céline, additional, Boada, Mercè, additional, Bousiges, Olivier, additional, Chapman, Miles D, additional, DeMarco, Mari L., additional, D'Onofrio, Mara, additional, Dumurgier, Julien, additional, Dufour‐Rainfray, Diane, additional, Engelborghs, Sebastiaan, additional, Esselmann, Hermann, additional, Fogli, Anne, additional, Gabelle, Audrey, additional, Galloni, Elisabetta, additional, Gondolf, Clémentine, additional, Grandhomme, Frédérique, additional, Grau‐Rivera, Oriol, additional, Hart, Melanie, additional, Ikeuchi, Takeshi, additional, Jeromin, Andreas, additional, Kasuga, Kensaku, additional, Keshavan, Ashvini, additional, Khalil, Michael, additional, Körtvelyessy, Peter, additional, Kulczynska‐Przybik, Agnieszka, additional, Laplanche, Jean‐Louis, additional, Lewczuk, Piotr, additional, Li, Qiao‐Xin, additional, Lleó, Alberto, additional, Malaplate, Catherine, additional, Marquié, Marta, additional, Masters, Colin L., additional, Mroczko, Barbara, additional, Nogueira, Léonor, additional, Orellana, Adelina, additional, Otto, Markus, additional, Oudart, Jean‐Baptiste, additional, Paquet, Claire, additional, Paoletti, Federico Paolini, additional, Parnetti, Lucilla, additional, Perret‐Liaudet, Armand, additional, Peoc'h, Katell, additional, Poesen, Koen, additional, Puig‐Pijoan, Albert, additional, Quadrio, Isabelle, additional, Quillard‐Muraine, Muriel, additional, Rucheton, Benoit, additional, Schraen, Susanna, additional, Schott, Jonathan M., additional, Shaw, Leslie M., additional, Suárez‐Calvet, Marc, additional, Tsolaki, Magda, additional, Tumani, Hayrettin, additional, Udeh‐Momoh, Chinedu T, additional, Vaudran, Lucie, additional, Verbeek, Marcel M, additional, Verde, Federico, additional, Vermunt, Lisa, additional, Vogelgsang, Jonathan, additional, Wiltfang, Jens, additional, Zetterberg, Henrik, additional, and Lehmann, Sylvain, additional

Published
2021
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50. Reduced Magnitude and Durability of Humoral Immune Responses to COVID-19 mRNA Vaccines Among Older Adults

Author

Brockman, Mark A, primary, Mwimanzi, Francis, additional, Lapointe, Hope R, additional, Sang, Yurou, additional, Agafitei, Olga, additional, Cheung, Peter K, additional, Ennis, Siobhan, additional, Ng, Kurtis, additional, Basra, Simran, additional, Lim, Li Yi, additional, Yaseen, Fatima, additional, Young, Landon, additional, Umviligihozo, Gisele, additional, Omondi, F Harrison, additional, Kalikawe, Rebecca, additional, Burns, Laura, additional, Brumme, Chanson J, additional, Leung, Victor, additional, Montaner, Julio S G, additional, Holmes, Daniel, additional, DeMarco, Mari L, additional, Simons, Janet, additional, Pantophlet, Ralph, additional, Niikura, Masahiro, additional, Romney, Marc G, additional, and Brumme, Zabrina L, additional

Published
2021
Full Text
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