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5 results on '"De-Qiang Feng"'

1. Uncarilic Acid and Secouncarilic Acid, Two New Triterpenoids from Uucaria sessilifructus

Author

Yan Li, De-Qiang Feng, You-Kai Xu, Shang-Gao Liao, Mao-Juan Zhang, Bing Liu, and Kai-Long Ji

Subjects
Uncaria sessilifructus, uncarilic acid, secouncarilic acid, triterpenoids, Organic chemistry, QD241-441
Abstract

Two new compounds, the 6-oxo oleanane-type triterpenoid uncarilic acid, and its 5,6-secotriterpenoid derivative, secouncarilic acid, were isolated from the hooks and stems of Uucaria sessilifructus together with seven known ursane-type triterpenoids. Uncarilic acid is the second 6-oxo oleanane-type triterpenoid ever reported, while secouncarilic acid is the first oleanane-type 5,6-secotriterpenoid. A plausible biosynthetic pathway from uncarilic acid to secouncarilic acid was also postulated. The inhibitory activities of all the nine compounds against LPS-induced nitric oxide production in RAW264.7 macrophages were evaluated.

Published
2013
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2. Uncarilic Acid and Secouncarilic Acid, Two New Triterpenoids from Uucaria sessilifructus

Author

Bing Liu, De-Qiang Feng, Kai-Long Ji, You-Kai Xu, Yan Li, Mao-Juan Zhang, and Shang-Gao Liao

Subjects
Lipopolysaccharides, Stereochemistry, Uncaria sessilifructus, Pharmaceutical Science, Nitric Oxide, Article, Analytical Chemistry, Nitric oxide, Cell Line, lcsh:QD241-441, chemistry.chemical_compound, Structure-Activity Relationship, Triterpenoid, lcsh:Organic chemistry, Drug Discovery, Organic chemistry, Humans, Secosteroids, Physical and Theoretical Chemistry, Oleanolic Acid, Inflammation, Molecular Structure, Chemistry, uncarilic acid, Macrophages, Organic Chemistry, secouncarilic acid, triterpenoids, Triterpenes, Uncaria, Chemistry (miscellaneous), Molecular Medicine, Derivative (chemistry)
Abstract

Two new compounds, the 6-oxo oleanane-type triterpenoid uncarilic acid, and its 5,6-secotriterpenoid derivative, secouncarilic acid, were isolated from the hooks and stems of Uucaria sessilifructus together with seven known ursane-type triterpenoids. Uncarilic acid is the second 6-oxo oleanane-type triterpenoid ever reported, while secouncarilic acid is the first oleanane-type 5,6-secotriterpenoid. A plausible biosynthetic pathway from uncarilic acid to secouncarilic acid was also postulated. The inhibitory activities of all the nine compounds against LPS-induced nitric oxide production in RAW264.7 macrophages were evaluated.

Published
2013

3. A new triterpenoid bearing octacosanoate from the stems and roots of Clerodendrum philippinum var. simplex (Verbenaceae)

Author

You-Kai Xu, De-Qiang Feng, and Jia-Rui Yue

Subjects
Lipopolysaccharides, Clerodendrum philippinum, Traditional medicine, Molecular Structure, Plant Stems, Clerodendrum, Verbenaceae, Macrophages, Organic Chemistry, Fatty Acids, Plant Science, Biology, biology.organism_classification, Nitric Oxide, Biochemistry, Plant Roots, Triterpenes, Analytical Chemistry, Cell Line, Mice, Triterpenoid, Botany, Abietanes, Uncinatone, Animals
Abstract

A new triterpenoid bearing octacosanoate, named taraxer-3β-yl octacosanoate (1), together with 13 known compounds (2–14), was isolated from the ethanol extract of the stems and roots of Clerodendrum philippinum var. simplex. The structure of taraxer-3β-yl octacosanoate (1) was elucidated by extensive spectroscopic analysis. Uncinatone (8) and clerodenone A (10) exhibited inhibition of lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophages with IC50 values of 12.50 and 3.18 μM, respectively.

Published
2015
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5. Uncarilic Acid and Secouncarilic Acid, Two New Triterpenoids from Uucaria sessilifructus.

Author

Mao-Juan Zhang, Bing Liu, Shang-Gao Liao, You-Kai Xu, De-Qiang Feng, Kai-Long Ji, and Yan Li

Subjects
TRITERPENOIDS, BIOSYNTHESIS, INHIBITORY postsynaptic potential, NITRIC oxide synthesis, MACROPHAGE activation
Abstract

Two new compounds, the 6-oxo oleanane-type triterpenoid uncarilic acid, and its 5,6-secotriterpenoid derivative, secouncarilic acid, were isolated from the hooks and stems of Uucaria sessilifructus together with seven known ursane-type triterpenoids. Uncarilic acid is the second 6-oxo oleanane-type triterpenoid ever reported, while secouncarilic acid is the first oleanane-type 5,6-secotriterpenoid. A plausible biosynthetic pathway from uncarilic acid to secouncarilic acid was also postulated. The inhibitory activities of all the nine compounds against LPS-induced nitric oxide production in RAW264.7 macrophages were evaluated. [ABSTRACT FROM AUTHOR]

Published
2013
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