1. Baicalensines A and B, Two Isoquinoline Alkaloids from the Roots of Thalictrum baicalense
- Author
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Jingjing Xue, Jin-Cai Lu, Bin-Jie Li, Hui-Ming Hua, Bin Lin, De-Li Zou, Zhan-Lin Li, Chun-Yu Jiang, and Dahong Li
- Subjects
010405 organic chemistry ,Stereochemistry ,Alkaloid ,Organic Chemistry ,Carbon-13 NMR ,Conjugated system ,010402 general chemistry ,01 natural sciences ,Biochemistry ,0104 chemical sciences ,chemistry.chemical_compound ,Berberine ,chemistry ,Molecule ,Physical and Theoretical Chemistry ,Isoquinoline ,Benzylisoquinoline ,Cytotoxicity - Abstract
Baicalensines A (1) and B (2) were isolated from the roots of Thalictrum baicalense and structurally characterized using spectroscopic data, 13C NMR calculations, and the CASE algorithm. Compound 1, representing a new class of alkaloid dimers, contains berberine conjugated to a ring-opened isoquinoline. Compound 2 is the first reported natural benzylisoquinoline bearing a formyl group at C-3. Plausible biosynthetic pathways are proposed. Compound 1 exerted moderate cytotoxicity against the Caco-2 and HL-60 cell lines.
- Published
- 2020