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1. Evaluation of National Surgical Practice for Lateral Lymph Nodes in Rectal Cancer in an Untrained Setting

Author

Sluckin, Tania C., Hazen, Sanne-Marije J. A., Horsthuis, Karin, Beets-Tan, Regina G. H., Aalbers, Arend G. J., Beets, Geerard L., Boerma, Evert-Jan G., Borstlap, Jaap, van Breest Smallenburg, Vivian, Burger, Jacobus W. A., Crolla, Rogier M. P. H., Daniëls-Gooszen, Alette W., Davids, Paul H. P., Dunker, Michalda S., Fabry, Hans F. J., Furnée, Edgar J. B., van Gils, Renza A. H., de Haas, Robbert J., Hoogendoorn, Stefan, van Koeverden, Sebastiaan, de Korte, Fleur I., Oosterling, Steven J., Peeters, Koen C. M. J., Posma, Lisanne A. E., Pultrum, Bareld B., Rothbarth, Joost, Rutten, Harm J. T., Schasfoort, Renske A., Schreurs, Wilhelmina H., Simons, Petra C. G., Smits, Anke B., Talsma, Aaldert K., The, G. Y. Mireille, van Tilborg, Fiek, Tuynman, Jurriaan B., Vanhooymissen, Inge J. S., van de Ven, Anthony W. H., Verdaasdonk, Emiel G. G., Vermaas, Maarten, Vliegen, Roy F. A., Vogelaar, F. Jeroen, de Vries, Marianne, Vroemen, Joy C., van Vugt, Sebastiaan T., Westerterp, Marinke, van Westreenen, Henderik L., de Wilt, Johannes H. W., van der Zaag, Edwin S., Zimmerman, David D. E., Marijnen, Corrie A. M., Tanis, Pieter J., and Kusters, Miranda

Published
2023
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2. ASO Visual Abstract: Evaluation of National Surgical Practice for Lateral Lymph Nodes in Rectal Cancer in an Untrained Setting

Author

Sluckin, Tania C., Hazen, Sanne-Marije J. A., Horsthuis, Karin, Beets-Tan, Regina G. H., Aalbers, Arend G. J., Beets, Geerard L., Boerma, Evert-Jan G., Borstlap, Jaap, van Breest Smallenburg, Vivian, Burger, Jacobus W. A., Crolla, Rogier M. P. H., Daniëls-Gooszen, Alette W., Davids, Paul H. P., Dunker, Michalda S., Fabry, Hans F. J., Furnée, Edgar J. B., van Gils, Renza A. H., de Haas, Robbert J., Hoogendoorn, Stefan, van Koeverden, Sebastiaan, de Korte, Fleur I., Oosterling, Steven J., Peeters, Koen C. M. J., Posma, Lisanne A. E., Pultrum, Bareld B., Rothbarth, Joost, Rutten, Harm J. T., Schasfoort, Renske A., Schreurs, Wilhelmina H., Simons, Petra C. G., Smits, Anke B., Talsma, Aaldert K., The, G. Y. Mireille, van Tilborg, Fiek, Tuynman, Jurriaan B., Vanhooymissen, Inge J., van de Ven, Anthony W. H., Verdaasdonk, Emiel G. G., Vermaas, Maarten, Vliegen, Roy F. A., Vogelaar, F. Jeroen, de Vries, Marianne, Vroemen, Joy C., van Vugt, Sebastiaan T., Westerterp, Marinke, van Westreenen, Henderik L., de Wilt, Johannes H. W., van der Zaag, Edwin S., Zimmerman, David D. E., Marijnen, Corrie A. M., Tanis, Pieter J., and Kusters, Miranda

Published
2023
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4. Treatment of Colorectal Lung Metastases: Two Centers Retrospective Study.

Author

Krul, Myrtle F., van Rees, Jan M., de Boer, Amihan M., Neve, Karlijn K., Verhoef, Cornelis, Kuhlmann, Koert F.D., Baetens, Tarik R., Buffart, Tineke E., Knegjens, Joost L., Klomp, Houke M., Ruers, Theo J.M., de Vries, Marianne, Rothbarth, Joost, van Meerten, Esther, Nuyttens, Joost J.M.E., Grünhagen, Dirk, and Kok, Niels F.M.

Abstract

Introduction: Clear guidelines for colorectal lung metastasis (LM) treatment are not available. This study aimed to provide insight into the treatment strategies and efficacy of local and systemic therapy in patients with LM eligible for (potentially) curative treatment. Methods: This was a retrospective study of patients with ≤5 LM discussed in two tertiary referral centers. Patient and tumor characteristics were compared between treatment groups. Treatment strategies were compared between centers and survival data between treatment groups, local treatment modalities, and treating centers. Results: Ninety-two patients (median 2 LMs) were included. Seventy-one (77%) patients underwent local treatment (17 surgery, 13 ablation, 38 radiotherapy, 3 combination of local treatments) and 21 (23%) with systemic therapy alone. The latter group more frequently had extrapulmonary metastases (81.0% vs. 26.8%, p < 0.001) and synchronous presentation of LM (23.8% vs. 7.0%, p = 0.045). Choice of local versus systemic therapy and time to start treatment after diagnosis (median 109 days, IQR 44–240 vs. 88 days, IQR 53–168) were comparable between centers. Three-year survival rates did not differ between treatment groups, local treatment modalities, or treating centers. Conclusion: Treatment strategies and oncological outcomes were rather similar between centers. Survival outcomes were not different between locally and systemically treated patients. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Abandonment of Routine Radiotherapy for Nonlocally Advanced Rectal Cancer and Oncological Outcomes

Author

Hazen, Sanne Marije J.A., Sluckin, Tania C., Intven, Martijn P.W., Beets, Geerard L., Beets-Tan, Regina G.H., Borstlap, Wernard A.A., Buffart, Tineke E., Buijsen, Jeroen, Burger, Jacobus W.A., Van Dieren, Susan, Furnée, Edgar J.B., Geijsen, E. Debby, Hompes, Roel, Horsthuis, Karin, Leijtens, Jeroen W.A., Maas, Monique, Melenhorst, Jarno, Nederend, Joost, Peeters, Koen C.M.J., Rozema, Tom, Tuynman, Jurriaan B., Verhoef, Cornelis, De Vries, Marianne, Van Westreenen, Henderik L., De Wilt, Johannes H.W., Zimmerman, David D.E., Marijnen, Corrie A.M., Tanis, Pieter J., Kusters, Miranda, Hazen, Sanne Marije J.A., Sluckin, Tania C., Intven, Martijn P.W., Beets, Geerard L., Beets-Tan, Regina G.H., Borstlap, Wernard A.A., Buffart, Tineke E., Buijsen, Jeroen, Burger, Jacobus W.A., Van Dieren, Susan, Furnée, Edgar J.B., Geijsen, E. Debby, Hompes, Roel, Horsthuis, Karin, Leijtens, Jeroen W.A., Maas, Monique, Melenhorst, Jarno, Nederend, Joost, Peeters, Koen C.M.J., Rozema, Tom, Tuynman, Jurriaan B., Verhoef, Cornelis, De Vries, Marianne, Van Westreenen, Henderik L., De Wilt, Johannes H.W., Zimmerman, David D.E., Marijnen, Corrie A.M., Tanis, Pieter J., and Kusters, Miranda

Abstract

Importance: Neoadjuvant short-course radiotherapy was routinely applied for nonlocally advanced rectal cancer (cT1-3N0-1M0 with >1 mm distance to the mesorectal fascia) in the Netherlands following the Dutch total mesorectal excision trial. This policy has shifted toward selective application after guideline revision in 2014. Objective: To determine the association of decreased use of neoadjuvant radiotherapy with cancer-related outcomes and overall survival at a national level. Design, Setting, and Participants: This multicenter, population-based, nationwide cross-sectional cohort study analyzed Dutch patients with rectal cancer who were treated in 2011 with a 4-year follow-up. A similar study was performed in 2021, analyzing all patients that were surgically treated in 2016. From these cohorts, all patients with cT1-3N0-1M0 rectal cancer and radiologically unthreatened mesorectal fascia were included in the current study. The data of the 2011 cohort were collected between May and October 2015, and the data of the 2016 cohort were collected between October 2020 and November 2021. The data were analyzed between May and October 2022. Main Outcomes and Measures: The main outcomes were 4-year local recurrence and overall survival rates. Results: Among the 2011 and 2016 cohorts, 1199 (mean [SD] age, 68 [11] years; 430 women [36%]) of 2095 patients (57.2%) and 1576 (mean [SD] age, 68 [10] years; 547 women [35%]) of 3057 patients (51.6%) had cT1-3N0-1M0 rectal cancer and were included, with proportions of neoadjuvant radiotherapy of 87% (2011) and 37% (2016). Four-year local recurrence rates were 5.8% and 5.5%, respectively (P =.99). Compared with the 2011 cohort, 4-year overall survival was significantly higher in the 2016 cohort (79.6% vs 86.4%; P <.001), with lower non-cancer-related mortality (13.8% vs 6.3%; P <.001). Conclusions and Relevance: The results of this cross-sectional study suggest that an absolute 50% reduction in radiotherapy use for nonlocally

Published
2024

8. Prognostic significance of MRI-detected extramural venous invasion according to grade and response to neo-adjuvant treatment in locally advanced rectal cancer A national cohort study after radiologic training and reassessment

Author

Geffen, Eline G.M. van, primary, Nederend, Joost, additional, Sluckin, Tania C., additional, Hazen, Sanne-Marije J.A., additional, Horsthuis, Karin, additional, Beets-Tan, Regina G.H., additional, Marijnen, Corrie A.M., additional, Tanis, Pieter J., additional, Kusters, Miranda, additional, Aalbers, Arend G.J., additional, van Aalten, Susanna M., additional, Amelung, Femke J., additional, Ankersmit, Marjolein, additional, Antonisse, Imogeen E., additional, Ashruf, Jesse F., additional, Aukema, Tjeerd S., additional, Avenarius, Henk, additional, Bahadoer, Renu R., additional, Bakers, Frans C.H., additional, Bakker, Ilsalien S., additional, Bangert, Fleur, additional, Barendse, Renée M., additional, Beekhuis, Heleen M.D., additional, Beets, Geerard L., additional, Bemelman, Willem A., additional, Berbée, Maaike, additional, de Bie, Shira H., additional, Bisschops, Robert H.C., additional, Blok, Robin D., additional, van Bockel, Liselotte W., additional, Boer, Anniek H., additional, den Boer, Frank C., additional, Boerma, Evert-Jan G., additional, Boogerd, Leonora S.F., additional, Borstlap, Jaap, additional, Borstlap, Wernard A.A., additional, Bouwman, Johanna E., additional, Braak, Sicco J., additional, Braat, Manon N.G.J.A., additional, Bradshaw, Jennifer, additional, Brandsma, Amarins T.A., additional, van Breest Smallenburg, Vivian, additional, van den Broek, Wim T., additional, van der Burg, Sjirk W., additional, Burger, Jacobus W.A., additional, Burghgraef, Thijs A., additional, ten Cate, David W.G., additional, Ceha, Heleen M., additional, Cnossen, Jeltsje S., additional, Coebergh van den Braak, Robert R.J., additional, Consten, Esther C.J., additional, Corver, Maaike, additional, Crolla, Rogier M.P.H., additional, Curutchet, Sam, additional, Daniëls-Gooszen, Alette W., additional, Davids, Paul H.P., additional, Dekker, Emmelie N., additional, Dekker, Jan Willem T., additional, Demirkiran, Ahmet, additional, Derksen, Tyche, additional, Diederik, Arjen L., additional, Dinaux, Anne M., additional, Dogan, Kemal, additional, van Dop, Ilse M., additional, Droogh-de Greve, Kitty E., additional, Duijsens, Hanneke M.H., additional, Dunker, Michalda S., additional, Duyck, Johan, additional, van Duyn, Eino B., additional, van Egdom, Laurentine S.E., additional, Eijlers, Bram, additional, El-Massoudi, Youssef, additional, van Elderen, Saskia, additional, Emmen, Anouk M.L.H., additional, Engelbrecht, Marc, additional, van Erp, Anne C., additional, van Essen, Jeroen A., additional, Fabry, Hans F.J., additional, Fassaert, Thomas, additional, Feitsma, Eline A., additional, Feshtali, Shirin S., additional, Frietman, Bas, additional, Furnée, Edgar J.B., additional, van Geel, Anne M., additional, Geijsen, Elisabeth D., additional, van Geloven, Anna A.W., additional, Gerhards, Michael F., additional, Gielkens, Hugo, additional, van Gils, Renza A.H., additional, Goense, Lucas, additional, Govaert, Marc J.P.M., additional, van Grevenstein, Wilhelmina M.U., additional, Joline de Groof, E., additional, de Groot, Irene, additional, de Haas, Robbert J., additional, Hakkenbrak, Nadia A.G., additional, den Hartogh, Mariska D., additional, Heesink, Vera, additional, Heikens, Joost T., additional, Hendriksen, Ellen M., additional, van den Hoek, Sjoerd, additional, van der Hoeven, Erik J.R.J., additional, Hoff, Christiaan, additional, Hogewoning, Anna, additional, Hogewoning, Cornelis R.C., additional, Hoogendoorn, Stefan, additional, van Hoorn, Francois, additional, van der Hul, René L., additional, van Hulst, Rieke, additional, Imani, Farshad, additional, Inberg, Bas, additional, Intven, Martijn P.W., additional, Janssen, Pedro, additional, de Jong, Chris E.J., additional, Jonkers, Jacoline, additional, Jou-Valencia, Daniela, additional, Keizers, Bas, additional, Ketelaers, Stijn H.J., additional, Knöps, Eva, additional, van Koeverden, Sebastiaan, additional, Kok, Sylvia, additional, Kolderman, Stephanie E.M., additional, de Korte, Fleur I., additional, Kortekaas, Robert T.J., additional, Korving, Julie C., additional, Koster, Ingrid M., additional, Krdzalic, Jasenko, additional, Krielen, Pepijn, additional, Kroese, Leonard F., additional, Krul, Eveline J.T., additional, Lahuis, Derk H.H., additional, Lamme, Bas, additional, van Landeghem, An A.G., additional, Leijtens, Jeroen W.A., additional, Leseman-Hoogenboom, Mathilde M., additional, de Lijster, Manou S., additional, Marsman, Martijn S., additional, Martens, MilouH., additional, Masselink, Ilse, additional, van der Meij, Wout, additional, Meijnen, Philip, additional, Melenhorst, Jarno, additional, de Mey, Dietrich J.L., additional, Moelker-Galuzina, Julia, additional, Morsink, Linda, additional, Mulder, Erik J., additional, Muller, Karin, additional, Musters, Gijsbert D., additional, Neijenhuis, Peter A., additional, de Nes, Lindsey C.F., additional, Nielen, M., additional, van den Nieuwboer, Jan B.J., additional, Nieuwenhuis, Jonanne F., additional, Nonner, Joost, additional, Noordman, Bo J., additional, Nordkamp, Stefi, additional, Olthof, Pim B., additional, Oosterling, Steven J., additional, Ootes, Daan, additional, Oppedijk, Vera, additional, Ott, Pieter, additional, Paulusma, Ida, additional, Peeters, Koen C.M.J., additional, Pereboom, Ilona T.A., additional, Peringa, Jan, additional, Pironet, Zoë, additional, Plate, Joost D.J., additional, Polat, Fatih, additional, Poodt, Ingrid G.M., additional, Posma, Lisanne A.E., additional, Prette, Jeroen F., additional, Pultrum, Bareld B., additional, Qaderi, Seyed M., additional, van Rees, Jan M., additional, Renger, Rutger-Jan, additional, Rombouts, Anouk J.M., additional, Roosen, Lodewijk J., additional, Roskott-ten Brinke, Ellen A., additional, Rothbarth, Joost, additional, Rouw, Dennis B., additional, Rozema, Tom, additional, Rütten, Heidi, additional, Rutten, Harm J.T., additional, van der Sande, Marit E., additional, Schaafsma, Boudewijn E., additional, Schasfoort, Renske A., additional, Scheurkogel, Merel M., additional, Schouten van der Velden, Arjan P., additional, Schreurs, Wilhelmina H., additional, Schuivens, Puck M.E., additional, Sietses, Colin, additional, Simons, Petra C.G., additional, Slob, Marjan J., additional, Slooter, Gerrit D., additional, van der Sluis, Martsje, additional, Smalbroek, Bo P., additional, Smits, Anke B., additional, Spillenaar-Bilgen, Ernst J., additional, Spruit, Patty H., additional, Stam, Tanja C., additional, Stoker, Jaap, additional, Talsma, Aaldert K., additional, Temmink, Sofieke J.D., additional, The, G.Y. Mireille, additional, Tielbeek, Jeroen A.W., additional, van Tilborg, Aukje A.J.M., additional, van Tilborg, Fiek, additional, van Trier, Dorothée, additional, Tuynman, Jurriaan B., additional, van der Valk, Maxime J.M., additional, Vanhooymissen, Inge J.S., additional, Vasbinder, G. Boudewijn C., additional, Veeken, Cornelis J., additional, Velema, Laura A., additional, van de Ven, Anthony W.H., additional, Verdaasdonk, Emiel G.G., additional, Verduin, Wouter M., additional, Verhagen, Tim, additional, Verheijen, Paul M., additional, Vermaas, Maarten, additional, Verrijssen, An-Sofie E., additional, Verschuur, Anna V.D., additional, Schaik, Harmke Verwoerd-van, additional, Vliegen, Roy F.A., additional, Voets, Sophie, additional, Vogelaar, F. Jeroen, additional, Vogelij, Clementine L.A., additional, Vos-Westerman, Johanna, additional, de Vries, Marianne, additional, Vroemen, Joy C., additional, van Vugt, Bas S.T., additional, Wegdam, Johannes A., additional, van Wely, Bob J., additional, Westerterp, Marinke, additional, van Westerveld, Paul P., additional, van Westreenen, Henderik L., additional, Wijma, Allard G., additional, de Wilt, Johannes H.W., additional, de Wit, Bart W.K., additional, Wit, Fennie, additional, Woensdregt, Karlijn, additional, van Woerden, Victor, additional, van der Wolf, Floor S.W., additional, van der Wolk, Sander, additional, Wybenga, Johannes M., additional, van der Zaag, Edwin S., additional, Zamaray, Bobby, additional, Zandvoort, Herman J.A., additional, van der Zee, Dennis, additional, Zeilstra, Annette P., additional, Zheng, Kang J., additional, Zimmerman, David D.E., additional, and Zorgdrager, Marcel, additional

Published
2024
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10. Abandonment of Routine Radiotherapy for Nonlocally Advanced Rectal Cancer and Oncological Outcomes

Author

Hazen, Sanne-Marije J. A., Sluckin, Tania C., Intven, Martijn P. W., Beets, Geerard L., Beets-Tan, Regina G. H., Borstlap, Wernard A. A., Buffart, Tineke E., Buijsen, Jeroen, Burger, Jacobus W. A., van Dieren, Susan, Furnée, Edgar J. B., Geijsen, E. Debby, Hompes, Roel, Horsthuis, Karin, Leijtens, Jeroen W. A., Maas, Monique, Melenhorst, Jarno, Nederend, Joost, Peeters, Koen C. M. J., Rozema, Tom, Tuynman, Jurriaan B., Verhoef, Cornelis, de Vries, Marianne, van Westreenen, Henderik L., de Wilt, Johannes H.W., Zimmerman, David D. E., Marijnen, Corrie A. M., Tanis, Pieter J., and Kusters, Miranda

Abstract

IMPORTANCE: Neoadjuvant short-course radiotherapy was routinely applied for nonlocally advanced rectal cancer (cT1-3N0-1M0 with >1 mm distance to the mesorectal fascia) in the Netherlands following the Dutch total mesorectal excision trial. This policy has shifted toward selective application after guideline revision in 2014. OBJECTIVE: To determine the association of decreased use of neoadjuvant radiotherapy with cancer-related outcomes and overall survival at a national level. DESIGN, SETTING, AND PARTICIPANTS: This multicenter, population-based, nationwide cross-sectional cohort study analyzed Dutch patients with rectal cancer who were treated in 2011 with a 4-year follow-up. A similar study was performed in 2021, analyzing all patients that were surgically treated in 2016. From these cohorts, all patients with cT1-3N0-1M0 rectal cancer and radiologically unthreatened mesorectal fascia were included in the current study. The data of the 2011 cohort were collected between May and October 2015, and the data of the 2016 cohort were collected between October 2020 and November 2021. The data were analyzed between May and October 2022. MAIN OUTCOMES AND MEASURES: The main outcomes were 4-year local recurrence and overall survival rates. RESULTS: Among the 2011 and 2016 cohorts, 1199 (mean [SD] age, 68 [11] years; 430 women [36%]) of 2095 patients (57.2%) and 1576 (mean [SD] age, 68 [10] years; 547 women [35%]) of 3057 patients (51.6%) had cT1-3N0-1M0 rectal cancer and were included, with proportions of neoadjuvant radiotherapy of 87% (2011) and 37% (2016). Four-year local recurrence rates were 5.8% and 5.5%, respectively (P = .99). Compared with the 2011 cohort, 4-year overall survival was significantly higher in the 2016 cohort (79.6% vs 86.4%; P &lt; .001), with lower non–cancer-related mortality (13.8% vs 6.3%; P &lt; .001). CONCLUSIONS AND RELEVANCE: The results of this cross-sectional study suggest that an absolute 50% reduction in radiotherapy use for nonlocally advanced rectal cancer did not compromise cancer-related outcomes at a national level. Optimizing clinical staging and surgery following the Dutch total mesorectal excision trial has potentially enabled safe deintensification of treatment.

Published
2024
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11. 'Complete response rate after neoadjuvant chemoradiotherapy with or without neoadjuvant chemotherapy in high-risk locally advanced rectal cancer: A comparison between two tertiary referral hospitals'

Author

Van Den Berg, Kim, primary, van Rees, Jan M., additional, Coolen, Liën M., additional, Nederend, Joost, additional, de Vries, Marianne, additional, van Verschuer, Victorien MT, additional, Rothbarth, Joost, additional, Rutten, Harm JT., additional, Verhoef, Cornelis, additional, and Burger, Jacobus WA., additional

Published
2023
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14. Revisiting the Role of Immunotherapy for Colorectal Cancer Treatment in Patients with Constitutional Mismatch Repair Deficiency

Author

Eikenboom, Ellis L, Michiels, Erna M C, Grünhagen, Dirk J, de Vries, Marianne, Wagner, Anja, Spaander, Manon CW, Clinical Genetics, Gastroenterology & Hepatology, Surgery, and Radiology & Nuclear Medicine

Subjects
SDG 3 - Good Health and Well-being, General Earth and Planetary Sciences, General Environmental Science
Abstract

Patients with constitutional mismatch repair deficiency syndrome(CMMRD) usually develop multiple tumors at a young age. Chemotherapywas previously shown to be less effective in these tumors. Recent reportssuggest immunotherapeutic treatment in CMMRD-associated tumors. Here,we present a CMMRD patient, successfully treated with immunotherapyfor metastasized colorectal cancer (CRC). A young adolescent male wasdiagnosed with T2N2M1 cecum carcinoma with liver metastases. Hereceived four initial doses of nivolumab (3 mg/kg) with ipilimumab (1 ml/kg) every three weeks, followed by 41 doses of nivolumab alone every twoweeks. A complete response was achieved; also pathological assessmentof removed liver metastases was indicative of a complete response. Atthe time of writing, 14 months after end of treatment, the CRC had notrecurred. Immunotherapeutic treatment resulted in a complete response ofthe primary CRC and metastases. Immunotherapy as first line treatmentshould be strongly considered in treatment of CMMRD-associated CRCs

Published
2022
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15. Thinking beyond the Obvious Boundaries in Mathematics: An Exploration of Joyous Discovery.

Author

de Vries, Marianne E.

Abstract

Ideas for the development of creative exploration in mathematics are offered, including games to play in class (e.g., card games and tangrams), competitions (sample problems), clubs and math evenings (math relays and treasure hunts), projects (possible topics in patchwork quilting, art, and music), and math camps. (DB)

Published
1992

21. COPD exacerbations in general practice: variability in oral prednisolone courses

Author

de Vries Marianne, Berendsen Annette J, Bosveld Henk EP, Kerstjens Huib AM, and van der Molen Thys

Subjects
Medicine (General), R5-920
Abstract

Abstract Background The use of oral corticosteroids as treatment of COPD exacerbations in primary care is well established and evidence-based. However, the most appropriate dosage regimen has not been determined and remains controversial. Corticosteroid therapy is associated with a number of undesirable side effects, including hyperglycaemias, so differences in prescribing might be relevant. This study examines the differences between GPs in dosage and duration of prednisolone treatment in patients with a COPD exacerbation. It also investigates the number of general practitioners (GPs) who adjust their treatment according to the presence of diabetic co-morbidity. Methods Cross-sectional study among 219 GPs and 25 GPs in training, located in the Northern part of the Netherlands. Results The response rate was 69%. Nearly every GP prescribed a continuous dose of prednisolone 30 mg per day. Among GPs there were substantial differences in treatment duration. GPs prescribed courses of five, seven, ten, or fourteen days. A course of seven days was most common. The duration of treatment depended on exacerbation and disease severity. A course of five days was especially prescribed in case of a less severe exacerbation. In a more severe exacerbation duration of seven to fourteen days was more common. Hardly any GP adjusted treatment to the presence of diabetic co-morbidity. Conclusion Under normal conditions GPs prescribe prednisolone quite uniformly, within the range of the current Dutch guidelines. There is insufficient guidance regarding how to adjust corticosteroid treatment to exacerbation severity, disease severity and the presence of diabetic co-morbidity. Under these circumstances, there is a substantial variation in treatment duration.

Published
2012
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22. Obesitas in de spreekkamer

Author

van der Valk, Eline, Savas, Mesut, Burgerhart, Jan Steven, de Vries, Marianne, van den Akker, Erica, van Rossum, Liesbeth, Internal Medicine, Medical Informatics, and Pediatrics

Published
2017

23. Quantitative analysis Of hepatocellular adenoma and focal nodular hyperplasia in the hepatobiliary phase: External validation of LLCER method using gadobenate dimeglumine as contrast agent

Author

Thomeer, Maarten G., primary, Gest, Bibiche, additional, van Beek, Hermen, additional, De Vries, Marianne, additional, Dwarkasing, Roy, additional, Klompenhouwer, Anne J., additional, De Man, Robert A., additional, IJzermans, Jan N., additional, and Braun, Loes, additional

Published
2017
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24. Sarcopenia/Muscle Mass is not a Prognostic Factor for Short- and Long-Term Outcome After Esophagectomy for Cancer

Author

Grotenhuis, Brechtje, Shapiro, J (Joël), Adrichem, Stefan, de Vries, Marianne, Koek, Marcel, Wijnhoven, Bas, van Lanschot, Jan, Grotenhuis, Brechtje, Shapiro, J (Joël), Adrichem, Stefan, de Vries, Marianne, Koek, Marcel, Wijnhoven, Bas, and van Lanschot, Jan

Abstract

Recent studies have suggested that sarcopenia is a prognostic risk indicator of postoperative complications and predicts survival in cancer patients. The aim of this study is to investigate whether sarcopenia is associated with postoperative short-term outcome (morbidity and mortality) and long-term survival in patients undergoing esophagectomy for cancer after neoadjuvant chemoradiotherapy. All patients who underwent neoadjuvant chemoradiotherapy followed by esophagectomy for cancer, and of whom an adequate CT scan was available, were included in the current study. The presence of sarcopenia was defined by CT imaging using cut-off values of the total cross-sectional muscle tissue measured transversely at the third lumbar level. A total number of 120 patients were eligible for analysis. Almost half of the patients (N = 54, 45 %) were classified as having sarcopenia; 24 sarcopenic patients (44 %) had overweight and 5 sarcopenic patients (9 %) were obese. Overall morbidity and mortality rate did not differ significantly between sarcopenic and non-sarcopenic patients, nor did long-term overall or disease-free survival. Also sarcopenic obesity was not associated with worse outcome. The presence of sarcopenia was not associated with a negative short- and long-term outcome in this selected group of esophageal cancer patients after neoadjuvant chemoradiotherapy followed by esophagectomy.

Published
2016

25. Value of Magnetic Resonance Cholangiopancreatography in Assessment of Nonanastomotic Biliary Strictures After Liver Transplantation

Author

den Dulk, A. Claire, primary, Wasser, Martin N.J.M., additional, Willemssen, François E.J.A., additional, Monraats, Melanie A., additional, de Vries, Marianne, additional, van den Boom, Rivka, additional, Ringers, Jan, additional, Verspaget, Hein W., additional, Metselaar, Herold J., additional, and van Hoek, Bart, additional

Published
2015
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26. Multicenter Randomized Controlled Trial of the Costs and Effects of Noninvasive Diagnostic Imaging in Patients with Peripheral Arterial Disease: The DIPAD Trial

Author

Ouwendijk, Rody, primary, de Vries, Marianne, additional, Stijnen, Theo, additional, Pattynama, Peter M. T., additional, van Sambeek, Marc R. H. M., additional, Buth, Jaap, additional, Tielbeek, Alexander V., additional, van der Vliet, Daan A., additional, SchutzeKool, Leo J., additional, Kitslaar, Peter J. E. H. M., additional, de Haan, Michiel W., additional, van Engelshoven, Jos M. A., additional, and Hunink, M. G. Myriam, additional

Published
2008
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27. Peripheral Arterial Disease: Clinical and Cost Comparisons between Duplex US and Contrast-enhanced MR Angiography—A Multicenter Randomized Trial

Author

de Vries, Marianne, primary, Ouwendijk, Rody, additional, Flobbe, Karin, additional, Nelemans, Patricia J., additional, Kessels, Alphons G., additional, Schurink, GeertWillem H., additional, van der Vliet, J. Adam, additional, Heijstraten, Frans M. J., additional, Cuypers, Philippe W. M., additional, Duijm, Lucien E. M., additional, van Engelshoven, Jos M. A., additional, Hunink, M. G. Myriam, additional, and de Haan, Michiel W., additional

Published
2006
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29. Accuracy of Semiautomated Analysis of 3D Contrast-Enhanced Magnetic Resonance Angiography for Detection and Quantification of Aortoiliac Stenoses

Author

de Vries, Marianne, primary, de Koning, Patrick J., additional, de Haan, Michiel W., additional, Kessels, Alphons G., additional, Nelemans, Patricia J., additional, Nijenhuis, Robbert J., additional, Planken, R Nils, additional, Vasbinder, G Boudewijn C., additional, van Engelshoven, Jos M. A., additional, van der Geest, Rob J., additional, and Leiner, Tim, additional

Published
2005
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32. Genotype-phenotype correlations in hepatocellular adenoma: an update of MRI findings.

Author

Thomeer, Maarten G, E Bröker, Mirelle E, Lussanet, Quido de, Biermann, Katharina, Dwarkasing, Roy S, Man, Rob de, Ijzermans, Jan N, Vries, Marianne de, de Lussanet, Quido, de Man, Rob, and de Vries, Marianne

Abstract

Hepatocellular adenoma (HCA) is a generally benign liver tumor with the potential for malignancy and bleeding. HCAs are categorized into four subtypes on the basis of genetic and pathological features: hepatocyte nuclear factor 1α-mutated HCA, β-catenin-mutated HCA, inflammatory HCA, and unclassified HCA. Magnetic resonance imaging (MRI) plays an important role in the diagnosis, subtype characterization, and detection of HCA complications; it is also used to differentiate HCA from focal nodular hyperplasia. In this review, we present an overview of the genetic abnormalities, oncogenesis, and typical and atypical MRI findings of specific subtypes of HCA using contrast-enhanced MRI with or without hepatobiliary contrast agents (gadobenate dimeglumine and gadoxetate disodium). We also discuss their different management implications after diagnosis. [ABSTRACT FROM AUTHOR]

Published
2014
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33. Understanding the Remarkable Stability of Well-Defined Dinuclear Copper(I) Carbene Complexes.

Author

Bienenmann RLM, de Vries MR, Lutz M, and Broere DLJ

Abstract

The synthesis of a well-defined dicopper carbene complex supported by the PNNP (2,7-bis(di-tert-butylphosphaneyl)methyl-1,8-naphthyridine) expanded pincer ligand is reported. This carbene complex is remarkably stable, even in the presence of air and water. The reactivity of this complex was explored towards typical carbene transfer substrates and its electronic structure was investigated. Using a combination of experiments and DFT calculations, the principles that underly the stability of dinuclear carbene complexes are probed., (© 2024 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH.)

Published
2024
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34. Performance of Contrast-Enhanced Sonography Versus MRI With a Liver-Specific Contrast Agent for Diagnosis of Hepatocellular Adenoma and Focal Nodular Hyperplasia.

Author

Bröker MEE, Taimr P, de Vries M, Braun LMM, de Man RA, Ijzermans JNM, and Dwarkasing RS

Subjects
Adolescent, Adult, Aged, Diagnosis, Differential, Female, Humans, Male, Middle Aged, Retrospective Studies, Ultrasonography methods, Young Adult, Adenoma, Liver Cell diagnostic imaging, Contrast Media, Focal Nodular Hyperplasia diagnostic imaging, Liver Neoplasms diagnostic imaging, Magnetic Resonance Imaging methods, Meglumine analogs & derivatives, Organometallic Compounds, Sulfur Hexafluoride
Abstract

OBJECTIVE. The purpose of this article is to compare contrast-enhanced sonography (CEUS) with sulfur hexafluoride with MRI with the liver-specific contrast agent gadobenate dimeglumine in the diagnosis of hepatocellular adenoma (HCA) and focal nodular hyperplasia (FNH) in a cohort of consecutive patients. MATERIALS AND METHODS. Patients referred to a tertiary center for hepatobiliary disease who had suspected HCA or FNH on MRI performed with an extracellular gadolinium-based contrast agent underwent a prospective workup including CEUS and MRI with a liver-specific contrast agent. Diagnosis was definite when the findings of CEUS and MRI with a liver-specific contrast agent were concordant; histopathologic examination (HPE) was performed for cases with discordant findings. Descriptive statistics and the association between categoric variables were presented as numbers and percentages and were assessed using the Fisher exact test. The primary analysis was patient based. Sensitivity, specificity, and AUC and predictive values for the diagnosis of HCA and FNH were calculated separately for CEUS and MRI with a liver-specific contrast agent. RESULTS. A total of 181 patients were selected for the first analysis. Findings from CEUS and MRI with a liver-specific contrast agent were concordant for 132 patients (73%) and discordant for 49 (27%). HPE was performed for 26 of the 49 patients with discordant findings (53%), with findings indeterminate for two of these patients, the findings of MRI with a liver-specific contrast agent correct for 21 of the remaining 24 patients (87.5%), and the findings of CEUS correct for three of these 24 patients (12.5%) ( p < 0.05). For further analysis, 156 patients with concordant findings or HPE-proven cases were included. For CEUS, the sensitivity and specificity for the diagnosis of HCA and FNH were 85% and 87%, respectively; the ROC AUC value was 0.856; and the positive predictive value and negative predictive value were 79% and 90%, respectively. For MRI with a liver-specific contrast agent, the sensitivity and specificity were 95% each, the ROC AUC value was 0.949, and the positive predictive value and negative predictive value were 92% and 97%, respectively, for the diagnosis of HCA and FNH. CONCLUSION. The findings of CEUS and MRI with a liver-specific contrast agent showed fair agreement for the diagnosis of HCA and FNH. MRI with a liver-specific contrast agent is diagnostically correct significantly more often than CEUS in cases with discordant findings that are HPE proven.

Published
2020
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35. Multicenter randomized controlled trial of the costs and effects of noninvasive diagnostic imaging in patients with peripheral arterial disease: the DIPAD trial.

Author

Ouwendijk R, de Vries M, Stijnen T, Pattynama PM, van Sambeek MR, Buth J, Tielbeek AV, van der Vliet DA, SchutzeKool LJ, Kitslaar PJ, de Haan MW, van Engelshoven JM, and Hunink MG

Subjects
Aged, Cohort Studies, Cost-Benefit Analysis, Female, Humans, Male, Middle Aged, Outcome Assessment, Health Care, Peripheral Vascular Diseases therapy, Quality of Life, Recovery of Function, Sensitivity and Specificity, Magnetic Resonance Angiography economics, Peripheral Vascular Diseases diagnosis, Tomography, X-Ray Computed economics, Ultrasonography, Doppler, Duplex economics
Abstract

Objective: The purpose of our study was to compare the costs and effects of three noninvasive imaging tests as the initial imaging test in the diagnostic workup of patients with peripheral arterial disease., Materials and Methods: Of 984 patients assessed for eligibility, 514 patients with peripheral arterial disease were randomized to MR angiography (MRA) or duplex sonography in three hospitals and to MRA or CT angiography (CTA) in one hospital. The outcome measures included the clinical utility, functional patient outcomes, quality of life, and actual diagnostic and therapeutic costs related to the initial imaging test during 6 months of follow-up., Results: With adjustment for potentially predictive baseline variables, the learning curve, and hospital setting, a significantly higher confidence and less additional imaging were found for MRA and CTA compared with duplex sonography. No statistically significant differences were found in improvement in functional patient outcomes and quality of life among the groups. The total costs were significantly higher for MRA and duplex sonography than for CTA., Conclusion: The results suggest that both CTA and MRA are clinically more useful than duplex sonography and that CTA leads to cost savings compared with both MRA and duplex sonography in the initial imaging evaluation of peripheral arterial disease.

Published
2008
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