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185 results on '"De Vooght, Karen M K"'

1. Challenging the dogma: Red blood cell‐directed autoimmunity as risk factor for red blood cell alloimmunisation after blood transfusion

Author

Oud, Josine A., primary, de Haas, Masja, additional, de Vooght, Karen M. K., additional, van de Kerkhof, Daan, additional, Som, Nel, additional, Péquériaux, Nathalie C. V., additional, Hudig, Francisca, additional, van der Bom, Johanna G., additional, Evers, Dorothea, additional, and Zwaginga, Jaap Jan, additional

Published
2024
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3. Transfusion of ever-pregnant donor red blood cells and mortality of male patients

Author

Centraal Diagnostisch Laboratorium, Other research (not in main researchprogram), Valk, Sarah J, Caram-Deelder, Camila, Groenwold, Rolf H H, Evers, Dorothea, De Vooght, Karen M K, Van de Kerkhof, Daan, Wondergem, Marielle J, Péquériaux, Nathalie C V, Hudig, Francisca, Zwaginga, Jaap Jan, Middelburg, Rutger A, Van der Bom, Johanna G, Centraal Diagnostisch Laboratorium, Other research (not in main researchprogram), Valk, Sarah J, Caram-Deelder, Camila, Groenwold, Rolf H H, Evers, Dorothea, De Vooght, Karen M K, Van de Kerkhof, Daan, Wondergem, Marielle J, Péquériaux, Nathalie C V, Hudig, Francisca, Zwaginga, Jaap Jan, Middelburg, Rutger A, and Van der Bom, Johanna G

Published
2024

4. Use and Waste of Reconstituted Whole Blood Exchange Transfusions: An 11-year National Observational Study

Author

Centraal Diagnostisch Laboratorium, Other research (not in main researchprogram), de Winter, Derek P, Lopriore, Enrico, Hulzebos, Christian V, Lukens, Michaël V, Klinkspoor, J H, van Bohemen, Michaela, Besten, Gijs den, de Vooght, Karen M K, Vrancken, Sabine L A G, Trompenaars, Amanda M P, Hoffmann-Haringsma, Angelique, Péquériaux, N C V, Andriessen, Peter, Gijzen, Karlijn, van Hillegersberg, J L A M, Zant, Janneke C, van Rossem, Maaike C, Gammeren, A J Adriaan van, Weerkamp, Floor, Counsilman, Clare E, Knol, F R, Schiering, I A M, Dubbink-Verheij, Gerdina H, Verweij, E J T Joanne, de Haas, Masja, WISE investigators, Centraal Diagnostisch Laboratorium, Other research (not in main researchprogram), de Winter, Derek P, Lopriore, Enrico, Hulzebos, Christian V, Lukens, Michaël V, Klinkspoor, J H, van Bohemen, Michaela, Besten, Gijs den, de Vooght, Karen M K, Vrancken, Sabine L A G, Trompenaars, Amanda M P, Hoffmann-Haringsma, Angelique, Péquériaux, N C V, Andriessen, Peter, Gijzen, Karlijn, van Hillegersberg, J L A M, Zant, Janneke C, van Rossem, Maaike C, Gammeren, A J Adriaan van, Weerkamp, Floor, Counsilman, Clare E, Knol, F R, Schiering, I A M, Dubbink-Verheij, Gerdina H, Verweij, E J T Joanne, de Haas, Masja, and WISE investigators

Published
2024

5. Donor pregnancies and transfusion recipient mortality: A role for red blood cell storage?

Author

Centraal Diagnostisch Laboratorium, Other research (not in main researchprogram), Valk, Sarah J, Caram-Deelder, Camila, Evers, Dorothea, de Vooght, Karen M K, van de Kerkhof, Daan, Wondergem, Marielle J, Péquériaux, Nathalie C V, Hudig, Francisca, Zwaginga, Jaap Jan, de Korte, Dirk, van de Watering, Leo M G, Middelburg, Rutger A, van der Bom, Johanna G, Centraal Diagnostisch Laboratorium, Other research (not in main researchprogram), Valk, Sarah J, Caram-Deelder, Camila, Evers, Dorothea, de Vooght, Karen M K, van de Kerkhof, Daan, Wondergem, Marielle J, Péquériaux, Nathalie C V, Hudig, Francisca, Zwaginga, Jaap Jan, de Korte, Dirk, van de Watering, Leo M G, Middelburg, Rutger A, and van der Bom, Johanna G

Published
2024

6. Efficacy and safety of daratumumab in pure red cell aplasia after allogeneic transplantation: Dutch real-world data

Author

Onderzoeksgroep Minnema, Researchteam, MS Hematologie, Cancer, Centraal Diagnostisch Laboratorium, Other research (not in main researchprogram), CTI Kuball, Infection & Immunity, Regenerative Medicine and Stem Cells, CTI De Witte, Weverling, Flores Gerrit, Roeven, Mieke W H, Nijssen, Klaartje Kasper, Broers, Annoek E C, Dovern, Elisabeth, van Rhenen, Anna, Sluis, Geerte van, Hazenberg, Carin, van Balen, Peter, Kuipers, Maria T, de Vooght, Karen M K, Morsink, Linde M, Kuball, Jürgen, Nur, Erfan, Dewitte, Moniek, Onderzoeksgroep Minnema, Researchteam, MS Hematologie, Cancer, Centraal Diagnostisch Laboratorium, Other research (not in main researchprogram), CTI Kuball, Infection & Immunity, Regenerative Medicine and Stem Cells, CTI De Witte, Weverling, Flores Gerrit, Roeven, Mieke W H, Nijssen, Klaartje Kasper, Broers, Annoek E C, Dovern, Elisabeth, van Rhenen, Anna, Sluis, Geerte van, Hazenberg, Carin, van Balen, Peter, Kuipers, Maria T, de Vooght, Karen M K, Morsink, Linde M, Kuball, Jürgen, Nur, Erfan, and Dewitte, Moniek

Published
2024

9. Donor pregnancies and transfusion recipient mortality: A role for red blood cell storage?

Author

Valk, Sarah J., Caram‐Deelder, Camila, Evers, Dorothea, de Vooght, Karen M. K., van de Kerkhof, Daan, Wondergem, Marielle J., Péquériaux, Nathalie C. V., Hudig, Francisca, Zwaginga, Jaap Jan, de Korte, Dirk, van de Watering, Leo M. G., Middelburg, Rutger A., and van der Bom, Johanna G.

Subjects
ERYTHROCYTES, PROPORTIONAL hazards models, BLOOD products, PREGNANCY
Abstract

Background and Objectives: Donor characteristics have been implicated in transfusion‐related adverse events. Uncertainty remains about whether sex, and specifically pregnancy history of the blood donor, could affect patient outcomes. Whether storage duration of the blood product could be important for patient outcomes has also been investigated, and a small detrimental effect of fresh products remains a possibility. Here, we hypothesize that fresh red blood cell products donated by ever‐pregnant donors are associated with mortality in male patients. Materials and Methods: We used data from a cohort study of adult patients receiving a first transfusion between 2005 and 2015 in the Netherlands. The risk of death after receiving a transfusion from one of five exposure categories (female never‐pregnant stored ≤10 days, female never‐pregnant stored >10 days, female ever‐pregnant stored ≤10 days, female ever‐pregnant stored >10 days and male stored for ≤10 days), compared to receiving a unit donated by a male donor, which was stored for >10 days (reference), was calculated using a Cox proportional hazards model. Results: The study included 42,456 patients who contributed 88,538 person‐years in total, of whom 13,948 died during the follow‐up of the study (33%). Fresh units (stored for ≤10 days) from ever‐pregnant donors were associated with mortality in male patients, but the association was not statistically significant (hazard ratio 1.39, 95% confidence interval 0.97–1.99). Sensitivity analyses did not corroborate this finding. Conclusion: These findings do not consistently support the notion that the observed association between ever‐pregnant donor units and mortality is mediated by blood product storage. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Transfusion of platelets, but not of red blood cells, is independently associated with nosocomial infections in the critically ill

Author

Engele, Leo J., Straat, Marleen, van Rooijen, Ingeborg H. M., de Vooght, Karen M. K., Cremer, Olaf L., Schultz, Marcus J., Bos, Lieuwe D. J., Juffermans, Nicole P., de Beer, Friso M., van Hooijdonk, Roosmarijn T. M., Huson, Mischa A., Schouten, Laura R. A., Schultz, Marcus J., van Vught, Lonneke A., Wiewel, Maryse A., Witteveen, Esther, Glas, Gerie J., Wieske, Luuk, van der Poll, Tom, Bonten, Marc. J. M., Frencken, Jos F., Klein Klouwenberg, Peter M. C., Ong, David S. Y., and MARS Consortium

Published
2016
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14. Transfusion-induced red blood cell alloimmunisation is unhampered in elderly patients

Author

Centraal Diagnostisch Laboratorium, Other research (not in main researchprogram), Oud, Josine A, Evers, Dorothea, de Haas, Masja, de Vooght, Karen M K, van de Kerkhof, Daan, Som, Nel, Péquériaux, Nathalie C V, Hudig, Francisca, van der Bom, Johanna G, Zwaginga, Jaap Jan, Centraal Diagnostisch Laboratorium, Other research (not in main researchprogram), Oud, Josine A, Evers, Dorothea, de Haas, Masja, de Vooght, Karen M K, van de Kerkhof, Daan, Som, Nel, Péquériaux, Nathalie C V, Hudig, Francisca, van der Bom, Johanna G, and Zwaginga, Jaap Jan

Published
2022

15. Donor-recipient sex is associated with transfusion-related outcomes in critically ill patients

Author

Medische Staf Intensive Care, Infection & Immunity, Centraal Diagnostisch Laboratorium, Other research (not in main researchprogram), Alshalani, Abdulrahman, Uhel, Fabrice, Cremer, Olaf L, Schultz, Marcus J, de Vooght, Karen M K, van Bruggen, Robin, Acker, Jason P, Juffermans, Nicole P, Medische Staf Intensive Care, Infection & Immunity, Centraal Diagnostisch Laboratorium, Other research (not in main researchprogram), Alshalani, Abdulrahman, Uhel, Fabrice, Cremer, Olaf L, Schultz, Marcus J, de Vooght, Karen M K, van Bruggen, Robin, Acker, Jason P, and Juffermans, Nicole P

Published
2022

16. Association between cardiovascular risk factors and intracranial hemorrhage in patients with acute leukemia

Author

Unit Opleiding Aios, CDL Staf Patiëntenzorg KC, Other research (not in main researchprogram), CTI Kuball, MS Hematologie, Infection & Immunity, Regenerative Medicine and Stem Cells, Cancer, Cornelissen, Loes L, Kreuger, Aukje L, Caram-Deelder, Camila, Huisman, Menno V, Middelburg, Rutger A, Kerkhoffs, Jean Louis H, von dem Borne, Peter A, Beckers, Erik A M, de Vooght, Karen M K, Kuball, Jürgen, van der Bom, Johanna G, Zwaginga, J J, Unit Opleiding Aios, CDL Staf Patiëntenzorg KC, Other research (not in main researchprogram), CTI Kuball, MS Hematologie, Infection & Immunity, Regenerative Medicine and Stem Cells, Cancer, Cornelissen, Loes L, Kreuger, Aukje L, Caram-Deelder, Camila, Huisman, Menno V, Middelburg, Rutger A, Kerkhoffs, Jean Louis H, von dem Borne, Peter A, Beckers, Erik A M, de Vooght, Karen M K, Kuball, Jürgen, van der Bom, Johanna G, and Zwaginga, J J

Published
2022

18. The effect of extended c, E and K matching in females under 45 years of age on the incidence of transfusion‐induced red blood cell alloimmunisation

Author

Oud, Josine A., primary, Evers, Dorothea, additional, de Haas, Masja, additional, de Vooght, Karen M. K., additional, van de Kerkhof, Daan, additional, Som, Nel, additional, Péquériaux, Nathalie C. V., additional, Hudig, Francisca, additional, Albersen, Arjan, additional, van der Bom, Johanna G., additional, and Zwaginga, Jaap Jan, additional

Published
2021
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19. International Forum on Transfusion Practices in Haematopoietic Stem‐Cell Transplantation: Responses

Author

Solves, Pilar, primary, Lozano, Miquel, additional, Zhiburt, Eugene, additional, Anguita Velasco, Javier, additional, Maria Pérez‐Corral, Ana, additional, Monsalvo‐Saornil, Silvia, additional, Yamazaki, Sho, additional, Okazaki, Hitoshi, additional, Selleng, Kathleen, additional, Aurich, Konstanze, additional, Krüger, William, additional, Buser, Andreas, additional, Holbro, Andreas, additional, Infanti, Laura, additional, Stehle, Gregor, additional, Pierelli, Luca, additional, Matteocci, Antonella, additional, Rigacci, Luigi, additional, De Vooght, Karen M. K., additional, Kuball, Jurgen H. E., additional, Fielding, Katherine L., additional, Westerman, David A., additional, Wood, Erica M., additional, Cohn, Claudia S., additional, Johnson, Andrew, additional, Koh, Mickey B. C., additional, Qadir, Dara, additional, Cserti‐Gazdewich, Christine, additional, Daguindau, Etienne, additional, Angelot‐Delettre, Fanny, additional, Tiberghien, Pierre, additional, Wendel‐Neto, Silvano, additional, Fachini, Roberta‐Maria, additional, Morton, Suzy, additional, Craddock, Charles, additional, Lumley, Matthew, additional, Antoniewicz‐Papis, Jolanta, additional, Hałaburda, Kazimierz, additional, Łętowska, Magdalena, additional, and Dunbar, Nancy, additional

Published
2021
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20. International Forum on Transfusion Practices in Haematopoietic Stem‐Cell Transplantation: Summary

Author

Solves, Pilar, primary, Lozano, Miquel, additional, Zhiburt, Eugene, additional, Anguita Velasco, Javier, additional, Maria Pérez‐Corral, Ana, additional, Monsalvo‐Saornil, Silvia, additional, Yamazaki, Sho, additional, Okazaki, Hitoshi, additional, Selleng, Kathleen, additional, Aurich, Konstanze, additional, Krüger, William, additional, Buser, Andreas, additional, Holbro, Andreas, additional, Infanti, Laura, additional, Stehle, Gregor, additional, Pierelli, Luca, additional, Matteocci, Antonella, additional, Rigacci, Luigi, additional, De Vooght, Karen M. K., additional, Kuball, Jurgen H. E., additional, Fielding, Katherine L., additional, Westerman, David A., additional, Wood, Erica M., additional, Cohn, Claudia S., additional, Johnson, Andrew, additional, Koh, Mickey B. C., additional, Qadir, Dara, additional, Cserti‐Gazdewich, Christine, additional, Daguindau, Etienne, additional, Angelot‐Delettre, Fanny, additional, Tiberghien, Pierre, additional, Wendel‐Neto, Silvano, additional, Fachini, Roberta‐Maria, additional, Morton, Suzy, additional, Craddock, Charles, additional, Lumley, Matthew, additional, Antoniewicz‐Papis, Jolanta, additional, Hałaburda, Kazimierz, additional, Łętowska, Magdalena, additional, and Dunbar, Nancy, additional

Published
2021
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26. Thrombocytopenia and the effect of platelet transfusions on the occurrence of intracranial hemorrhage in patients with acute leukemia – a nested case-control study

Author

Cornelissen, Loes L., primary, Kreuger, Aukje L., additional, Caram-Deelder, Camila, additional, Middelburg, Rutger A., additional, Kerkhoffs, Jean Louis H., additional, von dem Borne, Peter A., additional, Beckers, Erik A. M., additional, de Vooght, Karen M. K., additional, Kuball, Jürgen, additional, Zwaginga, J. J., additional, and van der Bom, Johanna G., additional

Published
2020
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27. Association between cardiovascular risk factors and intracranial hemorrhage in patients with acute leukemia.

Author

Cornelissen, Loes L., Kreuger, Aukje L., Caram‐Deelder, Camila, Huisman, Menno V., Middelburg, Rutger A., Kerkhoffs, Jean Louis H., von dem Borne, Peter A., Beckers, Erik A. M., de Vooght, Karen M. K., Kuball, Jürgen, van der Bom, Johanna G., and Zwaginga, Jaap Jan

Subjects
INTRACRANIAL hemorrhage, CARDIOVASCULAR diseases risk factors, ACUTE leukemia, MYOCARDIAL ischemia, CORONARY disease, ENDOTHELIUM diseases
Abstract

Background: Intracranial hemorrhage is seen more frequently in acute leukemia patients compared to the general population. Besides leukemia‐related risk factors, also risk factors that are present in the general population might contribute to hemorrhagic complications in leukemia patients. Of those, cardiovascular risk factors leading to chronic vascular damage could modulate the occurrence of intracranial hemorrhage in these patients, as during their disease and treatment acute endothelial damage occurs due to factors like thrombocytopenia and inflammation. Objectives: Our aim was to explore if cardiovascular risk factors can predict intracranial hemorrhage in acute leukemia patients. Methods: In a case‐control study nested in a cohort of acute leukemia patients, including 17 cases with intracranial hemorrhage and 55 matched control patients without intracranial hemorrhage, data on cardiovascular risk factors were collected for all patients. Analyses were performed via conditional logistic regression. Results: Pre‐existing hypertension and ischemic heart disease in the medical history were associated with intracranial hemorrhage, with an incidence rate ratio of 12.9 (95% confidence interval [CI] 1.5 to 109.2) and 12.1 (95% CI 1.3 to110.7), respectively. Conclusion: Both pre‐existing hypertension and ischemic heart disease seem to be strong predictors of an increased risk for intracranial hemorrhage in leukemia patients. [ABSTRACT FROM AUTHOR]

Published
2022
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28. Blood gas values during hypothermia in asphyxiated term neonates

Author

Groenendaal, Floris, De Vooght, Karen M. K., and van Bel, Frank

Subjects
Blood gases -- Physiological aspects, Blood gases -- Demographic aspects, Hypothermia -- Physiological aspects, Hypothermia -- Demographic aspects, Hypothermia -- Care and treatment, Asphyxia neonatorum -- Care and treatment, Blood gases -- Analysis, Blood gases -- Usage
Published
2009

29. Age of platelet concentrates and time to the next transfusion

Author

Caram-Deelder, Camila, van der Bom, Johanna G., Putter, Hein, Leyte, Anja, Kerkhof, Daan van de, Evers, Dorothea, Beckers, Erik A., Weerkamp, Floor, Hudig, Francisca, Zwaginga, Jaap Jan, Rondeel, Jan M. M., de Vooght, Karen M. K., Péquériaux, Nathalie C. V., Visser, Otto, Wallis, Jonathan P., Middelburg, Rutger A., MUMC+: MA Hematologie (9), RS: CARIM - R1.01 - Blood proteins & engineering, and VU University medical center

Subjects
COUNT INCREMENTS, STORAGE TIME, REFRACTORINESS, THROMBOCYTOPENIA, TRIAL, METAANALYSES
Abstract

BACKGROUND: Storage time of platelet (PLT) concentrates has been negatively associated with clinical efficacy outcomes. The aim of this study was to quantify the association between storage time of PLT concentrates and interval to the next PLT transfusion for different types of PLT components, stored for up to 7 days and transfused to transfusion-dependent hematooncology patients with thrombocytopenia. STUDY DESIGN AND METHODS: From a cohort of patients from 10 major Dutch hospitals, patients were selected whose transfusion patterns were compatible with PLT transfusion dependency due to hematooncologic disease. Mean time to the next transfusion and mean differences in time to the next transfusion for different storage time categories (i.e., fresh, 5 days) were estimated, per component type, using multilevel mixed-effects linear models. RESULTS: Among a cohort of 29,761 patients who received 140,896 PLT transfusions we selected 4441 hematooncology patients who had received 12,724 PLT transfusions during periods of PLT transfusion dependency. Transfusion of fresh, compared to old, buffy coat–derived PLTs in plasma was associated with a delay to the next transfusion of 6.2 hours (95% confidence interval [CI], 4.5-8.0 hr). For buffy coat–derived PLTs in PAS-B and -C this difference was 7.7 hours (95% CI, 2.2-13.3 hr) and 3.9 hours (95% CI, –2.1 to 9.9 hr) while for apheresis PLTs in plasma it was only 1.8 hours (95% CI, –3.5 to 7.1 hr). CONCLUSION: Our results indicate that the time to the next transfusion shortens with increasing age of transfused buffy coat–derived PLT concentrates. This association was not observed for apheresis PLTs.

Published
2018
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30. Storage time of platelet concentrates and all-cause bacteremia in hematologic patients

Author

Kreuger, Aukje L, Middelburg, Rutger A., Bank, Cock M C, Beckers, Erik A M, van Gammeren, Adriaan J, Leyte, Anja, Rondeel, Jan M.M., de Vooght, Karen M K, Weerkamp, Floor, Zwaginga, Jaap Jan, Kerkhoffs, Jean Louis H, van der Bom, Johanna G, MUMC+: MA Hematologie (9), and RS: CARIM - R1.01 - Blood proteins & engineering

Subjects
RISK, OUTCOMES, BACTERIAL-CONTAMINATION, TRANSFUSION-RELATED IMMUNOMODULATION, CRITICALLY-ILL, AMERICAN-RED-CROSS, SURVEILLANCE, COMPONENTS, Journal Article, EXPERIENCE, APHERESIS PLATELETS
Abstract

BACKGROUND: Extension of storage time of platelet (PLT) concentrates may result in an increased risk of bacteremia, directly via transfusion of contaminated products or indirectly via transfusion-related immunomodulation. We aimed to quantify the association of storage time of PLT concentrates and all-cause bacteremia in hematologic patients. STUDY DESIGN AND METHODS: We established a cohort of hematologic patients who received a PLT transfusion between 2005 and 2015. Cases were defined as patients with a bacteremia the day after transfusion and matched to as many controls as possible. A conditional logistic regression was performed, stratified by storage medium. RESULTS: Among 3514 patients receiving 36,032 PLT concentrates stored in plasma, 613 cases of bacteremia were found. The relative risk of all-cause bacteremia the day after transfusion was 0.80 (95% confidence interval [CI], 0.58-1.12) for PLT concentrates stored 3 to 4 days and 0.67 (95% CI, 0.49-0.92) for at least 5 days, compared to no more than 2 days. Among 1527 patients receiving 11,822 PLT concentrates stored in PLT additive solution, 182 cases of bacteremia were found. The relative risk of all-cause bacteremia was 1.14 (95% CI, 0.70-1.84) for PLT concentrates stored for 3 to 4 days and 1.19 (95% CI, 0.70-2.01) for at least 5 days, compared to not more than 2 days. CONCLUSION: Storage time of PLT concentrates was not associated with increased occurrence of all-cause bacteremia the day after transfusion. If anything, fewer cases of bacteremia occurred with increasing storage time of PLT concentrates in plasma. These bacteremias are not directly caused by transfusion of a contaminated product and the underlying mechanism warrants further research.

Published
2017

33. The identification of cases of major hemorrhage during hospitalization in patients with acute leukemia using routinely recorded healthcare data

Author

CDL Staf Patiëntenzorg KC, Other research (not in main researchprogram), Kreuger, Aukje L, Middelburg, Rutger A, Beckers, Erik A M, de Vooght, Karen M K, Zwaginga, Jaap Jan, Kerkhoffs, Jean-Louis H, van der Bom, Johanna G, CDL Staf Patiëntenzorg KC, Other research (not in main researchprogram), Kreuger, Aukje L, Middelburg, Rutger A, Beckers, Erik A M, de Vooght, Karen M K, Zwaginga, Jaap Jan, Kerkhoffs, Jean-Louis H, and van der Bom, Johanna G

Published
2018

34. Protocol for a national blood transfusion data warehouse from donor to recipient:Bmj Open

Author

van Hoeven, L. R., Hooftman, B. H., Janssen, M. P., de Bruijne, M. C., de Vooght, Karen M K, Kemper, P., Koopman, M.M.W., Cardio-thoracic surgery, Public and occupational health, EMGO - Quality of care, and ICaR - Heartfailure and pulmonary arterial hypertension

Abstract

Introduction: Blood transfusion has health-related, economical and safety implications. In order to optimise the transfusion chain, comprehensive research data are needed. The Dutch Transfusion Data warehouse (DTD) project aims to establish a data warehouse where data from donors and transfusion recipients are linked. This paper describes the design of the data warehouse, challenges and illustrative applications. Study design and methods: Quantitative data on blood donors (eg, age, blood group, antibodies) and products (type of product, processing, storage time) are obtained from the national blood bank. These are linked to data on the transfusion recipients (eg, transfusions administered, patient diagnosis, surgical procedures, laboratory parameters), which are extracted from hospital electronic health records. Applications: Expected scientific contributions are illustrated for 4 applications: determine risk factors, predict blood use, benchmark blood use and optimise process efficiency. For each application, examples of research questions are given and analyses planned. Conclusions: The DTD project aims to build a national, continuously updated transfusion data warehouse. These data have a wide range of applications, on the donor/production side, recipient studies on blood usage and benchmarking and donor-recipient studies, which ultimately can contribute to the efficiency and safety of blood transfusion.

Published
2016
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36. Absence of the spleen and the occurrence of primary red cell alloimmunization in humans

Author

Evers, Dorothea, van der Bom, Johanna G, Tijmensen, Janneke, de Haas, Masja, Middelburg, Rutger A., de Vooght, Karen M K, van de Kerkhof, Daan, Visser, Otto J, Péquériaux, Nathalie C V, Hudig, Francisca, Zwaginga, Jaap Jan, Evers, Dorothea, van der Bom, Johanna G, Tijmensen, Janneke, de Haas, Masja, Middelburg, Rutger A., de Vooght, Karen M K, van de Kerkhof, Daan, Visser, Otto J, Péquériaux, Nathalie C V, Hudig, Francisca, and Zwaginga, Jaap Jan

Published
2017

37. Association of Blood Transfusion From Female Donors With and Without a History of Pregnancy With Mortality Among Male and Female Transfusion Recipients

Author

CDL Staf Patiëntenzorg KC, Other research (not in main researchprogram), Caram-Deelder, Camila, Kreuger, Aukje L, Evers, Dorothea, de Vooght, Karen M K, van de Kerkhof, Daan, Visser, Otto J, Péquériaux, Nathalie C V, Hudig, Francisca, Zwaginga, Jaap Jan, van der Bom, Johanna G, Middelburg, Rutger A., CDL Staf Patiëntenzorg KC, Other research (not in main researchprogram), Caram-Deelder, Camila, Kreuger, Aukje L, Evers, Dorothea, de Vooght, Karen M K, van de Kerkhof, Daan, Visser, Otto J, Péquériaux, Nathalie C V, Hudig, Francisca, Zwaginga, Jaap Jan, van der Bom, Johanna G, and Middelburg, Rutger A.

Published
2017

38. Storage time of platelet concentrates and all-cause bacteremia in hematologic patients

Author

CDL Staf Patiëntenzorg KC, Other research (not in main researchprogram), Kreuger, Aukje L, Middelburg, Rutger A., Bank, Cock M C, Beckers, Erik A M, van Gammeren, Adriaan J, Leyte, Anja, Rondeel, Jan M.M., de Vooght, Karen M K, Weerkamp, Floor, Zwaginga, Jaap Jan, Kerkhoffs, Jean Louis H, van der Bom, Johanna G, CDL Staf Patiëntenzorg KC, Other research (not in main researchprogram), Kreuger, Aukje L, Middelburg, Rutger A., Bank, Cock M C, Beckers, Erik A M, van Gammeren, Adriaan J, Leyte, Anja, Rondeel, Jan M.M., de Vooght, Karen M K, Weerkamp, Floor, Zwaginga, Jaap Jan, Kerkhoffs, Jean Louis H, and van der Bom, Johanna G

Published
2017

39. Absence of the spleen and the occurrence of primary red cell alloimmunization in humans

Author

CDL Staf Patiëntenzorg KC, Other research (not in main researchprogram), Evers, Dorothea, van der Bom, Johanna G, Tijmensen, Janneke, de Haas, Masja, Middelburg, Rutger A., de Vooght, Karen M K, van de Kerkhof, Daan, Visser, Otto J, Péquériaux, Nathalie C V, Hudig, Francisca, Zwaginga, Jaap Jan, CDL Staf Patiëntenzorg KC, Other research (not in main researchprogram), Evers, Dorothea, van der Bom, Johanna G, Tijmensen, Janneke, de Haas, Masja, Middelburg, Rutger A., de Vooght, Karen M K, van de Kerkhof, Daan, Visser, Otto J, Péquériaux, Nathalie C V, Hudig, Francisca, and Zwaginga, Jaap Jan

Published
2017

40. When blood transfusion medicine becomes complicated due to interference by monoclonal antibody therapy

Author

Oostendorp, Marlies, Lammerts Van Bueren, Jeroen J., Doshi, Parul, Khan, Imran, Ahmadi, Tahamtan, Parren, Paul W H I, Van Solinge, Wouter W., and De Vooght, Karen M K

Subjects
Research Support, Non-U.S. Gov't, Immunology, Journal Article, Immunology and Allergy, Hematology
Abstract

BACKGROUND Monoclonal antibodies (MoAbs) are increasingly integrated in the standard of care. The notion that therapeutic MoAbs can interfere with clinical laboratory tests is an emerging concern that requires immediate recognition and the development of appropriate solutions. Here, we describe that treatment of multiple myeloma patients with daratumumab, a novel anti-CD38 MoAb, resulted in false-positive indirect antiglobulin tests (IATs) for all patients for 2 to 6 months after infusion. This precluded the correct identification of irregular blood group antibodies for patients requiring blood transfusion. STUDY DESIGN AND METHODS The IAT was performed using three- and 11-donor-cell panels. Interference of daratumumab and three other anti-CD38 MoAbs was studied using fresh-frozen plasma spiked with different MoAb concentrations. Additionally it was tested whether two potentially neutralizing agents, anti-idiotype antibody and recombinant soluble CD38 (sCD38) extracellular domain, were able to inhibit the interference. RESULTS The CD38 MoAbs caused agglutination in the IAT in a dose-dependent manner. Addition of an excess of anti-idiotype antibodies or sCD38 protein to the test abrogated CD38 MoAb interference and successfully restored irregular antibody screening and identification. DISCUSSION CD38 MoAb therapy causes false-positive results in the IAT. The reliability of the test could be restored by adding a neutralizing agent against the CD38 MoAb to the patient's plasma. This study emphasizes that during drug development, targeted therapeutics should be investigated for potential interference with laboratory tests. Clinical laboratories should be informed when patients receive MoAb treatments and matched laboratory tests to prevent interference should be employed.

Published
2015

43. Red cell alloimmunisation in patients with different types of infections

Author

Evers, Dorothea, van der Bom, Johanna G, Tijmensen, Janneke, Middelburg, Rutger A, de Haas, Masja, Zalpuri, Saurabh, de Vooght, Karen M K, van de Kerkhof, Daan, Visser, Otto, Péquériaux, Nathalie C V, Hudig, Francisca, Zwaginga, Jaap Jan, Evers, Dorothea, van der Bom, Johanna G, Tijmensen, Janneke, Middelburg, Rutger A, de Haas, Masja, Zalpuri, Saurabh, de Vooght, Karen M K, van de Kerkhof, Daan, Visser, Otto, Péquériaux, Nathalie C V, Hudig, Francisca, and Zwaginga, Jaap Jan

Published
2016

44. New mAb therapies in multiple myeloma: interference with blood transfusion compatibility testing

Author

Other research (not in main researchprogram), CDL Staf Patiëntenzorg KC, LKCH Staf Patiëntenzorg, Centraal Diagnostisch Laboratorium, Infection & Immunity, Circulatory Health, de Vooght, Karen M K, Oostendorp, Marlies, van Solinge, Wouter W., Other research (not in main researchprogram), CDL Staf Patiëntenzorg KC, LKCH Staf Patiëntenzorg, Centraal Diagnostisch Laboratorium, Infection & Immunity, Circulatory Health, de Vooght, Karen M K, Oostendorp, Marlies, and van Solinge, Wouter W.

Published
2016

45. Red cell alloimmunisation in patients with different types of infections

Author

Other research (not in main researchprogram), CDL Staf Patiëntenzorg KC, Evers, Dorothea, van der Bom, Johanna G, Tijmensen, Janneke, Middelburg, Rutger A, de Haas, Masja, Zalpuri, Saurabh, de Vooght, Karen M K, van de Kerkhof, Daan, Visser, Otto, Péquériaux, Nathalie C V, Hudig, Francisca, Zwaginga, Jaap Jan, Other research (not in main researchprogram), CDL Staf Patiëntenzorg KC, Evers, Dorothea, van der Bom, Johanna G, Tijmensen, Janneke, Middelburg, Rutger A, de Haas, Masja, Zalpuri, Saurabh, de Vooght, Karen M K, van de Kerkhof, Daan, Visser, Otto, Péquériaux, Nathalie C V, Hudig, Francisca, and Zwaginga, Jaap Jan

Published
2016

46. Red-blood-cell alloimmunisation in relation to antigens' exposure and their immunogenicity: A cohort study

Author

LKCH Staf Patiëntenzorg, Other research (not in main researchprogram), CDL Staf Patiëntenzorg KC, Evers, Dorothea, Middelburg, Rutger A., de Haas, Masja, Zalpuri, Saurabh, de Vooght, Karen M K, van de Kerkhof, Daan, Visser, Otto, Péquériaux, Nathalie C., Hudig, Francisca, Schonewille, Henk, Zwaginga, Jaap Jan, van der Bom, Johanna G., LKCH Staf Patiëntenzorg, Other research (not in main researchprogram), CDL Staf Patiëntenzorg KC, Evers, Dorothea, Middelburg, Rutger A., de Haas, Masja, Zalpuri, Saurabh, de Vooght, Karen M K, van de Kerkhof, Daan, Visser, Otto, Péquériaux, Nathalie C., Hudig, Francisca, Schonewille, Henk, Zwaginga, Jaap Jan, and van der Bom, Johanna G.

Published
2016

47. Transfusion of platelets, but not of red blood cells, is independently associated with nosocomial infections in the critically ill

Author

CDL Patiëntenzorg KC, Other research (not in main researchprogram), Medische Staf Intensive Care, Infection & Immunity, Engele, Leo J., Straat, Marleen, van Rooijen, Ingeborg H M, de Vooght, Karen M K, Cremer, Olaf L., Schultz, Marcus J., Bos, Lieuwe D J, Juffermans, Nicole P., CDL Patiëntenzorg KC, Other research (not in main researchprogram), Medische Staf Intensive Care, Infection & Immunity, Engele, Leo J., Straat, Marleen, van Rooijen, Ingeborg H M, de Vooght, Karen M K, Cremer, Olaf L., Schultz, Marcus J., Bos, Lieuwe D J, and Juffermans, Nicole P.

Published
2016

48. Protocol for a national blood transfusion data warehouse from donor to recipient

Author

HTA Onderzoek Team 2, HEE, Circulatory Health, JC onderzoeksprogramma Methodologie, LKCH Staf Patiëntenzorg, Other research (not in main researchprogram), CDL Staf Patiëntenzorg KC, van Hoeven, Loan R, Hooftman, Babette H, Janssen, Mart P, de Bruijne, Martine C, de Vooght, Karen M K, Kemper, Peter, Koopman, Maria M W, HTA Onderzoek Team 2, HEE, Circulatory Health, JC onderzoeksprogramma Methodologie, LKCH Staf Patiëntenzorg, Other research (not in main researchprogram), CDL Staf Patiëntenzorg KC, van Hoeven, Loan R, Hooftman, Babette H, Janssen, Mart P, de Bruijne, Martine C, de Vooght, Karen M K, Kemper, Peter, and Koopman, Maria M W

Published
2016

49. Red cell alloimmunisation in patients with different types of infections

Author

Evers, Dorothea, primary, van der Bom, Johanna G., additional, Tijmensen, Janneke, additional, Middelburg, Rutger A., additional, de Haas, Masja, additional, Zalpuri, Saurabh, additional, de Vooght, Karen M. K., additional, van de Kerkhof, Daan, additional, Visser, Otto, additional, Péquériaux, Nathalie C. V., additional, Hudig, Francisca, additional, and Zwaginga, Jaap Jan, additional

Published
2016
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