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5 results on '"De Silva, Maneka"'

2. GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child and adult BMI

Author

Alves, Alexessander Couto, De Silva, Maneka, Karhunen, Ville, Sovio, Ulla, Das, Shikta, Taal, H Rob, Warrington, Nicole M., Lewin, Alex, Kaakinen, Marika, Cousminer, Diana L., Thiering, Elisabeth, Timpson, Nicholas, Bond, Tom A, Lowry, Estelle, Brown, Christopher, Estivill, Xavier, Lindi, Virpi, Bradfield, Jonathan P, Geller, Frank, Speed, Doug, Coin, Lachlan J M, Loh, Marie, Barton, Sheila J, Beilin, Lawrence J, Bisgaard, Hans, Bonnelykke, Klaus, Alili, Rohia, Hatoum, Ida, Schramm, Katharina, Cartwright, Rufus, Charles, Marie-Aline, Salerno, Vincenzo, Clement, Karine, Claringbould, Annique, van Duijn, CM, Moltchanova, Elena, Frayling, Timothy, Freathy, Rachel, Lawlor, Debbie, Ring, Susan, Davey Smith, George, McCarthy, Mark I, and Järvelin, Marjo-Riitta

Abstract

Early childhood growth patterns are associated with adult health, yet the genetic factors and the developmental stages involved are not fully understood. Here, we combine genome-wide association studies with modeling of longitudinal growth traits to study the genetics of infant and child growth, followed by functional, pathway, genetic correlation, risk score, and colocalization analyses to determine how developmental timings, molecular pathways, and genetic determinants of these traits overlap with those of adult health. We found a robust overlap between the genetics of child and adult body mass index (BMI), with variants associated with adult BMI acting as early as 4 to 6 years old. However, we demonstrated a completely distinct genetic makeup for peak BMI during infancy, influenced by variation at the LEPR/LEPROT locus. These findings suggest that different genetic factors control infant and child BMI. In light of the obesity epidemic, these findings are important to inform the timing and targets of prevention strategies.

Published
2019
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3. Cohort Profile:The DynaHEALTH consortium - a European consortium for a life-course bio-psychosocial model of healthy ageing of glucose homeostasis

Author

Sebert, Sylvain, Lowry, Estelle, Aumuller, Nicole, Bermudez, Mercedes G., Bjerregaard, Lise G., de Rooij, Susanne R., De Silva, Maneka, El Marroun, Hanan, Hummel, Nadine, Juola, Teija, Mason, Giacomo, Much, Daniela, Oliveros, Elena, Poupakis, Stavros, Rautio, Nina, Schwarzfischer, Phillipp, Tzala, Evangelia, Uhl, Olaf, van de Beek, Cornelieke, Vehmeijer, Florianne, Verdejo-Roman, Juan, Wasenius, Niko, Webster, Claire, Ala-Mursula, Leena, Herzig, Karl-Heinz, Keinanen-Kiukaanniemi, Sirkka, Miettunen, Jouko, Baker, Jennifer L., Campoy, Cristina, Conti, Gabriella, Eriksson, Johan G., Hummel, Sandra, Jaddoe, Vincent, Koletzko, Berthold, Lewin, Alex, Rodriguez-Palermo, Maria, Roseboom, Tessa, Rueda, Ricardo, Evans, Jayne, Felix, Janine F., Prokopenko, Inga, Sorensen, Thorkild I. A., Jarvelin, Marjo-Riitta, Sebert, Sylvain, Lowry, Estelle, Aumuller, Nicole, Bermudez, Mercedes G., Bjerregaard, Lise G., de Rooij, Susanne R., De Silva, Maneka, El Marroun, Hanan, Hummel, Nadine, Juola, Teija, Mason, Giacomo, Much, Daniela, Oliveros, Elena, Poupakis, Stavros, Rautio, Nina, Schwarzfischer, Phillipp, Tzala, Evangelia, Uhl, Olaf, van de Beek, Cornelieke, Vehmeijer, Florianne, Verdejo-Roman, Juan, Wasenius, Niko, Webster, Claire, Ala-Mursula, Leena, Herzig, Karl-Heinz, Keinanen-Kiukaanniemi, Sirkka, Miettunen, Jouko, Baker, Jennifer L., Campoy, Cristina, Conti, Gabriella, Eriksson, Johan G., Hummel, Sandra, Jaddoe, Vincent, Koletzko, Berthold, Lewin, Alex, Rodriguez-Palermo, Maria, Roseboom, Tessa, Rueda, Ricardo, Evans, Jayne, Felix, Janine F., Prokopenko, Inga, Sorensen, Thorkild I. A., and Jarvelin, Marjo-Riitta

Published
2019

4. Cohort Profile: The DynaHEALTH consortium – a European consortium for a life-course bio-psychosocial model of healthy ageing of glucose homeostasis

Author

Sebert, Sylvain, primary, Lowry, Estelle, additional, Aumüller, Nicole, additional, Bermúdez, Mercedes G, additional, Bjerregaard, Lise G, additional, de Rooij, Susanne R, additional, De Silva, Maneka, additional, El Marroun, Hanan, additional, Hummel, Nadine, additional, Juola, Teija, additional, Mason, Giacomo, additional, Much, Daniela, additional, Oliveros, Elena, additional, Poupakis, Stavros, additional, Rautio, Nina, additional, Schwarzfischer, Phillipp, additional, Tzala, Evangelia, additional, Uhl, Olaf, additional, van de Beek, Cornelieke, additional, Vehmeijer, Florianne, additional, Verdejo-Román, Juan, additional, Wasenius, Niko, additional, Webster, Claire, additional, Ala-Mursula, Leena, additional, Herzig, Karl-Heinz, additional, Keinänen-Kiukaanniemi, Sirkka, additional, Miettunen, Jouko, additional, Baker, Jennifer L, additional, Campoy, Cristina, additional, Conti, Gabriella, additional, Eriksson, Johan G, additional, Hummel, Sandra, additional, Jaddoe, Vincent, additional, Koletzko, Berthold, additional, Lewin, Alex, additional, Rodriguez-Palermo, Maria, additional, Roseboom, Tessa, additional, Rueda, Ricardo, additional, Evans, Jayne, additional, Felix, Janine F, additional, Prokopenko, Inga, additional, Sørensen, Thorkild I A, additional, and Järvelin, Marjo-Riitta, additional

Published
2019
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5. DNA methylation links prenatal smoking exposure to later life health outcomes in offspring

Author

Wiklund, Petri, primary, Karhunen, Ville, additional, Richmond, Rebecca C, additional, Rodriguez, Alina, additional, De Silva, Maneka, additional, Wielscher, Matthias, additional, Rezwan, Faisal I, additional, Richardson, Tom G, additional, Veijola, Juha, additional, Heinz-Herzig, Karl, additional, Holloway, John W, additional, Relton, Caroline L, additional, Sebert, Sylvain, additional, and Järvelin, Marjo-Riitta, additional

Published
2018
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