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1. Long−term health outcome and quality of life in children with multisystem inflammatory syndrome: findings from multidisciplinary follow−up at an Italian tertiary−care paediatric hospital

Author

D’Auria, Enza, Bova, Stefania Maria, Dallapiccola, Andrea Riccardo, De Santis, Raffaella, Leone, Alessandro, Calcaterra, Valeria, Mannarino, Savina, Garbin, Massimo, Olivotto, Sara, Zirpoli, Salvatore, Ghezzi, Michele, Munari, Alice Marianna, Verduci, Elvira, Farolfi, Andrea, Bosetti, Alessandra, Perico, Veronica, Capetti, Pietro, Gadda, Arianna, Gianolio, Laura, Lo Monaco, Germana, Lonoce, Luisa, Previtali, Roberto, Serafini, Ludovica, Taranto, Silvia, Veggiotti, Pierangelo, and Zuccotti, Gianvincenzo

Published
2024
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2. Long-term cytokine profile in multisystem inflammatory disease among children

Author

Calcaterra, Valeria, Loretelli, Cristian, Biganzoli, Davide, Abdelsalam, Ahmed, Marano, Giuseppe, Carelli, Stephana, Fiori, Laura, Mannarino, Savina, D’Auria, Enza, Verduci, Elvira, De Santis, Raffaella, Dilillo, Dario, Fabiano, Valentina, Carlucci, Patrizia, Maghraby, Erika, Messa, Letizia, Cereda, Cristina, Fiorina, Paolo, Biganzoli, Elia, and Zuccotti, Gianvincenzo

Published
2024
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3. Use of music therapy in pediatric oncology: an Italian AIEOP multicentric survey study in the era of COVID-19

Author

Giordano, Filippo, Muggeo, Paola, Rutigliano, Chiara, Barzaghi, Federica, Battisti, Laura, Coccia, Paola, Colombini, Antonella, D’Amico, Maria Rosaria, De Santis, Raffaella, Mascarin, Maurizio, Mura, Rossella, Onofrillo, Daniela, Perruccio, Katia, Rinieri, Simona, Trevisan, Francesca, Zama, Daniele, Ziino, Ottavio, De Lucia, Marica, Santoro, Nicola, and Cesaro, Simone

Published
2023
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4. Favorable outcome of SARS-CoV-2 infection in pediatric hematology oncology patients during the second and third pandemic waves in Italy: a multicenter analysis from the Infectious Diseases Working Group of the Associazione Italiana di Ematologia e Oncologia Pediatrica (AIEOP)

Author

Zama, Daniele, Baccelli, Francesco, Colombini, Antonella, Contino, Amalia, Calore, Elisabetta, Petris, Maria Grazia, Meneghello, Linda, Mercolini, Federico, Lo Vecchio, Andrea, Montalto, Shana, Meazza, Cristina, Barone, Angelica, Compagno, Francesca, Muggeo, Paola, Soncini, Elena, Brescia, Letizia, Giraldi, Eugenia, Giurici, Nagua, Mura, Rosa Maria, Cellini, Monica, Perruccio, Katia, Petroni, Valeria, La Spina, Milena, Ziino, Ottavio, Burnelli, Roberta, De Santis, Raffaella, Mascarin, Maurizio, Barretta, Valentina, Tridello, Gloria, and Cesaro, Simone

Published
2022
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6. Long−term health outcome and quality of life in children with multisystem inflammatory syndrome: findings from multidisciplinary follow−up at an Italian tertiary−care paediatric hospital.

Author

D'Auria, Enza, Bova, Stefania Maria, Dallapiccola, Andrea Riccardo, De Santis, Raffaella, Leone, Alessandro, Calcaterra, Valeria, Mannarino, Savina, Garbin, Massimo, Olivotto, Sara, Zirpoli, Salvatore, Ghezzi, Michele, Munari, Alice Marianna, Verduci, Elvira, Farolfi, Andrea, Bosetti, Alessandra, Perico, Veronica, Capetti, Pietro, Gadda, Arianna, Gianolio, Laura, and Lo Monaco, Germana

Subjects
MULTISYSTEM inflammatory syndrome in children, MULTISYSTEM inflammatory syndrome, CHILDREN'S hospitals, QUALITY of life, WELL-being
Abstract

Multisystem inflammatory syndrome is a severe complication of SARS-CoV-2 infection in children (MIS-C). To date, data on long-term sequelae mainly concern cardiac outcomes. All ≤ 18 year olds consecutively admitted to the Buzzi Children's Hospital with a diagnosis of MIS-C between October 1, 2020, and May 31, 2022, were followed up for up to 12 months by a dedicated multidisciplinary team. They underwent laboratory tests, multi-organ clinical and instrumental assessments, and psychosocial evaluation. 56/62 patients, 40 M, mean age 8.7 years (95% CI 7.7, 9.7), completed the follow-up. Cardiological, gastroenterological, pneumological, and neurological evaluations, including IQ and EEG, were normal. Alterations of HOMA-IR index and/or TyG index, observed in almost all patients during hospitalisation, persisted in about a third of the population at 12 months. At 6 and 12 months respectively, impairment of adaptive functions was observed in 38/56 patients (67.9%) and 25/56 (44.6%), emotional and behavioural problems in 10/56 (17.9%) and 9/56 (16.1%), and decline in QoL in 14/56 (25.0%) and 9/56 (16.1%). Psychosocial well-being impairment was significantly more frequent in the subgroup with persistent glycometabolic dysfunction at 12 months (75% vs. 40.9% p < 0.001). Conlusion: The mechanisms that might explain the long-term persistence of both metabolic alterations and neuro-behavioural outcomes and their possible relationship are far from being clarified. Our study points out to the potential long-term effects of pandemics and to the importance of a multidisciplinary follow-up to detect potential negative sequelae in different areas of health, both physical and psychosocial. What is known: • Multisystem inflammatory syndrome in children (MIS-C) is a severe complication of SARS-CoV-2 infection. • Few data exist on the medium- and long-term outcomes of MIS-C, mostly focused on cardiac involvement. Emerging evidence shows neurological and psychological sequelae at mid- and long-term follow-up. What is new: • This study reveals that MIS-C may lead to long-term glycometabolic dysfunctions joined to impairment in the realm of general well-being and decline in quality of life, in a subgroup of children. • This study highlights the importance of a long-term multidisciplinary follow-up of children hospitalised with MIS-C, in order to detect the potential long-term sequelae in different areas of health, both physical and psychosocial well-being. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Global characteristics and outcomes of SARS-CoV-2 infection in children and adolescents with cancer (GRCCC): a cohort study

Author

Ribelles, A Juan, Balduzzi, Adriana, Elhaddad, Alaa, Casanovas, Alejandra, Garcia Velazquez, Alejandra, Laptsevich, Aliaksandra, Chang, Alicia, F. Sampaio, Alessandra Lamenha, González Prieto, Almudena, Lassaletta, Alvaro, Suarez M, Amaranto, Alcasabas, Ana Patricia, Colita, Anca, Morales La Madrid, Andres, Samudio, Angélica, Tondo, Annalisa, Colombini, Antonella, Kattamis, Antonis, Lopez Facundo, N Araceli, Bhattacharyya, Arpita, Alimi, Aurélia, Phulpin, Aurélie, Vakrmanova, Barbora, Aksoy, Basak A, Brethon, Benoit, Kobuin, Jator Brian, Nolasco Monteiro, Carla, Paillard, Catherine, Vezina, Catherine, Ceyhun, Bozkurt, Hentea, Cristiana, Meazza, Cristina, Ortiz-Morales, Daniel, Solorzano, Roque Daniel, Arce Cabrera, Daniela, Zama, Daniele, Ghosh, Debjani, Ramírez-Rivera, Diana, Calle Jara, Doris A, Janic, Dragana, Rey Helo, Elianneth, Gouache, Elodie, Guerrero Quiroz, Enmanuel, Lopez, Enrique, Thebault, Eric, Maradiegue, Essy, de Berranger, Eva, Ebeid, Fatma S E, Galaverna, Federica, Antillon-Klussmann, Federico, Espinoza Chacur, Felipe, Negro, Fernando Daniel, Carraro, Francesca, Compagno, Francesca, Barriga, Francisco, Tamayo Pedraza, Gabriela, Sanchez Fernandez, Gissela, Naidu, Gita, Tokuc, Gülnur, Alias, Hamidah, B Segocio, Hannah Grace, Boudiaf, Houda, Asetre Luna, Imelda, Maia, Iris, Astigarraga, Itziar, Maza, Ivan, Montoya Vásquez, Jacqueline E, Jazbec, Janez, Lazic, Jelena, Beck Dean, Jeniffer, Rouger-Gaudichon, Jeremie, Contreras González, Johanny Carolina, Huerta Aragonés, Jorge, Fuster, José L, Quintana, Juan, Palma, Julia, Svojgr, Karel, Quintero, Karina, Malic Tudor, Karolina, Georgantzi, Kleopatra, P Schultz, Kris Ann, Ureña Horno, Laura, Fraquelli, Lidia, Meneghello, Linda, Shalaby, Lobna, Macias Mora, Lola L, A Renner, Lorna, Nunes Silva, Luciana, Sisinni, Luisa, Hammad, Mahmoud, Fernández Sanmartín, M, Zubieta A, C Marcela, Drozdowski, María Constanza, Kourti, Maria, Palladino, Marcela María, Miranda Madrazo, Maria R, Poiree, Marilyne, Popova, Marina, Melgar, Mario, Baragaño, Marta, Avilés-Robles, Martha J, Provenzi, Massimo, Mendes Lins, Mecneide, Fatih Orhan, Mehmet, Villarroel, Milena, Jerónimo, Mónica, Varas Palma, Mónica, Rafie Raza, Muhammad, M Justin, Mulindwa, Shaheen, Najma, Domínguez-Pinilla, Nerea, Whipple, Nicholas S, André, Nicolas, Hrusak, Ondrej, Velasco Puyó, Pablo, Zacasa Vargas, Pamela, Olate Mellado, Paola, Yola Gassant, Pascale, Diaz Romero, Paulina, De Santis, Raffaella, Kebudi, Rejin, Boranbayeva, Riza, Vasquez, Roberto, Segura, Romel A., Rosado, Roy Enrique, Gómez, Sandra, Raimbault, Sandra, Gunasekera, Sanjeeva, Makkeyah, Sara M, Buyukkapu Bay, Sema, M Gómez, Sergio, Bouttefroy, Séverine, Islam, Shahnoor, Abouelnaga, Sherif, Torres, Silvio Fabio, Cesaro, Simone, Nunes, Sofia, Rouxinol, Soraia, Bhaumik, Sucharita, Saliyeva, Symbat, Inostroza, Tamara, Velasquez, Thelma, Hnin, Tint Myo, Norén-Nyström, Ulrika, Baretta, Valentina, Jimenez-Antolinez, Yajaira Valentine, Pérez Alonso, Vanesa, Ayer Miller, Vanessa, Gandemer, Virginie, Lotero, Viviana, Mishkova, Volha, Gómez-García, Wendy, Margaryan, Yeva, Syed, Yumna, Mukkada, Sheena, Bhakta, Nickhill, Chantada, Guillermo L, Chen, Yichen, Vedaraju, Yuvanesh, Faughnan, Lane, Homsi, Maysam R, Muniz-Talavera, Hilmarie, Ranadive, Radhikesh, Metzger, Monika, Friedrich, Paola, Agulnik, Asya, Jeha, Sima, Lam, Catherine, Dalvi, Rashmi, Hessissen, Laila, Moreira, Daniel C, Santana, Victor M, Sullivan, Michael, Bouffet, Eric, Caniza, Miguela A, Devidas, Meenakshi, Pritchard-Jones, Kathy, and Rodriguez-Galindo, Carlos

Published
2021
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9. Long-Term Health Outcome and Quality of Life in Children with Multisystem Inflammatory Syndrome: Findings from Multidisciplinary Follow Up at an Italian Tertiary-Care Paediatric Hospital

Author

D&apos;Auria, Enza, primary, Bova, Stefania Maria, additional, Dallapiccola, Andrea Riccardo, additional, De Santis, Raffaella, additional, Leone, Alessandro, additional, Calcaterra, Valeria, additional, Mannarino, Savina, additional, Garbin, Massimo, additional, Olivotto, Sara, additional, Zirpoli, Salvatore, additional, Ghezzi, Michele, additional, Munari, Alice Marianna, additional, Verduci, Elvira, additional, Farolfi, Andrea, additional, Bosetti, Alessandra, additional, Perico, Veronica, additional, Capetti, Pietro, additional, Gadda, Arianna, additional, Gianolio, Laura, additional, Lo Monaco, Germana, additional, Lonoce, Luisa, additional, Previtali, Roberto, additional, Serafini, Ludovica, additional, Taranto, Silvia, additional, Veggiotti, Pierangelo, additional, and Zuccotti, Gian Vincenzo, additional

Published
2024
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10. The SARS-CoV-2 infection in the pediatric oncology population: the definitive comprehensive report of Infectious Diseases Working Group (IDWG) of AIEOP

Author

Zama, Daniele, primary, Zanaroli, Andrea, additional, Corbelli, Agnese, additional, Lo Vecchio, Andrea, additional, Del Bene, Margherita, additional, Colombini, Antonella, additional, Compagno, Francesca, additional, Barone, Angelica, additional, Fontanili, Ilaria, additional, D’Amico, Maria Rosaria, additional, Papa, Maria Rosaria, additional, Petris, Maria Grazia, additional, Calore, Elisabetta, additional, Montalto, Shana, additional, Meneghello, Linda, additional, Brescia, Letizia, additional, Mura, Rosamaria, additional, La Spina, Milena, additional, Muggeo, Paola, additional, Rinieri, Simona, additional, Meazza, Cristina, additional, Perruccio, Katia, additional, Cellini, Monica, additional, Spadea, Manuela, additional, Mercolini, Federico, additional, Petroni, Valeria, additional, De Santis, Raffaella, additional, Soncini, Elena, additional, Provenzi, Massimo, additional, Giurici, Nagua, additional, Ziino, Ottavio, additional, Tridello, Gloria, additional, and Cesaro, Simone, additional

Published
2023
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12. Hemophagocytic inflammatory syndrome in ADA-SCID: report of two cases and literature review

Author

Fratini, Elena Sophia, primary, Migliavacca, Maddalena, additional, Barzaghi, Federica, additional, Fossati, Claudia, additional, Giannelli, Stefania, additional, Monti, Ilaria, additional, Casiraghi, Miriam, additional, Ferrua, Francesca, additional, Recupero, Salvatore, additional, Consiglieri, Giulia, additional, Calbi, Valeria, additional, Tucci, Francesca, additional, Gallo, Vera, additional, Bernardo, Maria Ester, additional, Cenciarelli, Sabina, additional, Palmoni, Monica, additional, Moni, Margherita, additional, Galimberti, Luca, additional, Duse, Marzia, additional, Leonardi, Lucia, additional, Sieni, Elena, additional, Soncini, Elena, additional, Porta, Fulvio, additional, Notarangelo, Lucia Dora, additional, De Santis, Raffaella, additional, Ladogana, Saverio, additional, Aiuti, Alessandro, additional, and Cicalese, Maria Pia, additional

Published
2023
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13. Six-month multidisciplinary follow-up in multisystem inflammatory syndrome in children: An Italian single-center experience

Author

Zuccotti, Gianvincenzo, primary, Calcaterra, Valeria, additional, Mannarino, Savina, additional, D’Auria, Enza, additional, Bova, Stefania Maria, additional, Fiori, Laura, additional, Verduci, Elvira, additional, Milanese, Alberto, additional, Marano, Giuseppe, additional, Garbin, Massimo, additional, Zirpoli, Salvatore, additional, Fabiano, Valentina, additional, Carlucci, Patrizia, additional, Olivotto, Sara, additional, Gianolio, Laura, additional, De Santis, Raffaella, additional, Pelizzo, Gloria, additional, Zoia, Elena, additional, Dilillo, Dario, additional, and Biganzoli, Elia Mario, additional

Published
2023
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14. Use of music therapy in pediatric oncology: an Italian AIEOP multicentric survey study in the era of COVID-19

Author

Giordano, Filippo, primary, Muggeo, Paola, additional, Rutigliano, Chiara, additional, Barzaghi, Federica, additional, Battisti, Laura, additional, Coccia, Paola, additional, Colombini, Antonella, additional, D’Amico, Maria Rosaria, additional, De Santis, Raffaella, additional, Mascarin, Maurizio, additional, Mura, Rossella, additional, Onofrillo, Daniela, additional, Perruccio, Katia, additional, Rinieri, Simona, additional, Trevisan, Francesca, additional, Zama, Daniele, additional, Ziino, Ottavio, additional, De Lucia, Marica, additional, Santoro, Nicola, additional, and Cesaro, Simone, additional

Published
2022
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15. Consensus on COVID-19 Vaccination in Pediatric Oncohematological Patients, on Behalf of Infectious Working Group of Italian Association of Pediatric Hematology Oncology

Author

Cesaro, Simone, primary, Muggeo, Paola, additional, Zama, Daniele, additional, Cellini, Monica, additional, Perruccio, Katia, additional, Colombini, Antonella, additional, Carraro, Francesca, additional, Petris, Maria Grazia, additional, Petroni, Valeria, additional, Mascarin, Maurizio, additional, Baccelli, Francesco, additional, Soncini, Elena, additional, Mura, Rosamaria, additional, La Spina, Milena, additional, Decembrino, Nunzia, additional, Burnelli, Roberta, additional, Frenos, Stefano, additional, Castagnola, Elio, additional, Faraci, Maura, additional, Meazza, Cristina, additional, Barzaghi, Federica, additional, D’Amico, Maria Rosaria, additional, Capasso, Maria, additional, Calore, Elisabetta, additional, Ziino, Ottavio, additional, Barone, Angelica, additional, Compagno, Francesca, additional, Luti, Laura, additional, Galaverna, Federica, additional, De Santis, Raffaella, additional, Brescia, Letizia, additional, Meneghello, Linda, additional, Petrone, Angelamaria, additional, Giurici, Nagua, additional, Onofrillo, Daniela, additional, Schumacher, Fabian, additional, and Mercolini, Federico, additional

Published
2022
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16. Ecthyma Gangrenosum in Children With Cancer: Diagnosis at a Glance: A Retrospective Study From the Infection Working Group of Italian Pediatric Hematology Oncology Association

Author

Muggeo, Paola, primary, Zama, Daniele, additional, Decembrino, Nunzia, additional, Onofrillo, Daniela, additional, Frenos, Stefano, additional, Colombini, Antonella, additional, Perruccio, Katia, additional, Calore, Elisabetta, additional, Giurici, Nagua, additional, Ficara, Monica, additional, La Spina, Milena, additional, Mura, Rosamaria, additional, De Santis, Raffaella, additional, Santoro, Nicola, additional, and Cesaro, Simone, additional

Published
2022
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17. Global characteristics and outcomes of SARS-CoV-2 infection in children and adolescents with cancer (GRCCC): a cohort study

Author

Mukkada, Sheena, primary, Bhakta, Nickhill, additional, Chantada, Guillermo L, additional, Chen, Yichen, additional, Vedaraju, Yuvanesh, additional, Faughnan, Lane, additional, Homsi, Maysam R, additional, Muniz-Talavera, Hilmarie, additional, Ranadive, Radhikesh, additional, Metzger, Monika, additional, Friedrich, Paola, additional, Agulnik, Asya, additional, Jeha, Sima, additional, Lam, Catherine, additional, Dalvi, Rashmi, additional, Hessissen, Laila, additional, Moreira, Daniel C, additional, Santana, Victor M, additional, Sullivan, Michael, additional, Bouffet, Eric, additional, Caniza, Miguela A, additional, Devidas, Meenakshi, additional, Pritchard-Jones, Kathy, additional, Rodriguez-Galindo, Carlos, additional, Ribelles, A Juan, additional, Balduzzi, Adriana, additional, Elhaddad, Alaa, additional, Casanovas, Alejandra, additional, Garcia Velazquez, Alejandra, additional, Laptsevich, Aliaksandra, additional, Chang, Alicia, additional, F. Sampaio, Alessandra Lamenha, additional, González Prieto, Almudena, additional, Lassaletta, Alvaro, additional, Suarez M, Amaranto, additional, Alcasabas, Ana Patricia, additional, Colita, Anca, additional, Morales La Madrid, Andres, additional, Samudio, Angélica, additional, Tondo, Annalisa, additional, Colombini, Antonella, additional, Kattamis, Antonis, additional, Lopez Facundo, N Araceli, additional, Bhattacharyya, Arpita, additional, Alimi, Aurélia, additional, Phulpin, Aurélie, additional, Vakrmanova, Barbora, additional, Aksoy, Basak A, additional, Brethon, Benoit, additional, Kobuin, Jator Brian, additional, Nolasco Monteiro, Carla, additional, Paillard, Catherine, additional, Vezina, Catherine, additional, Ceyhun, Bozkurt, additional, Hentea, Cristiana, additional, Meazza, Cristina, additional, Ortiz-Morales, Daniel, additional, Solorzano, Roque Daniel, additional, Arce Cabrera, Daniela, additional, Zama, Daniele, additional, Ghosh, Debjani, additional, Ramírez-Rivera, Diana, additional, Calle Jara, Doris A, additional, Janic, Dragana, additional, Rey Helo, Elianneth, additional, Gouache, Elodie, additional, Guerrero Quiroz, Enmanuel, additional, Lopez, Enrique, additional, Thebault, Eric, additional, Maradiegue, Essy, additional, de Berranger, Eva, additional, Ebeid, Fatma S E, additional, Galaverna, Federica, additional, Antillon-Klussmann, Federico, additional, Espinoza Chacur, Felipe, additional, Negro, Fernando Daniel, additional, Carraro, Francesca, additional, Compagno, Francesca, additional, Barriga, Francisco, additional, Tamayo Pedraza, Gabriela, additional, Sanchez Fernandez, Gissela, additional, Naidu, Gita, additional, Tokuc, Gülnur, additional, Alias, Hamidah, additional, B Segocio, Hannah Grace, additional, Boudiaf, Houda, additional, Asetre Luna, Imelda, additional, Maia, Iris, additional, Astigarraga, Itziar, additional, Maza, Ivan, additional, Montoya Vásquez, Jacqueline E, additional, Jazbec, Janez, additional, Lazic, Jelena, additional, Beck Dean, Jeniffer, additional, Rouger-Gaudichon, Jeremie, additional, Contreras González, Johanny Carolina, additional, Huerta Aragonés, Jorge, additional, Fuster, José L, additional, Quintana, Juan, additional, Palma, Julia, additional, Svojgr, Karel, additional, Quintero, Karina, additional, Malic Tudor, Karolina, additional, Georgantzi, Kleopatra, additional, P Schultz, Kris Ann, additional, Ureña Horno, Laura, additional, Fraquelli, Lidia, additional, Meneghello, Linda, additional, Shalaby, Lobna, additional, Macias Mora, Lola L, additional, A Renner, Lorna, additional, Nunes Silva, Luciana, additional, Sisinni, Luisa, additional, Hammad, Mahmoud, additional, Fernández Sanmartín, M, additional, Zubieta A, C Marcela, additional, Drozdowski, María Constanza, additional, Kourti, Maria, additional, Palladino, Marcela María, additional, Miranda Madrazo, Maria R, additional, Poiree, Marilyne, additional, Popova, Marina, additional, Melgar, Mario, additional, Baragaño, Marta, additional, Avilés-Robles, Martha J, additional, Provenzi, Massimo, additional, Mendes Lins, Mecneide, additional, Fatih Orhan, Mehmet, additional, Villarroel, Milena, additional, Jerónimo, Mónica, additional, Varas Palma, Mónica, additional, Rafie Raza, Muhammad, additional, M Justin, Mulindwa, additional, Shaheen, Najma, additional, Domínguez-Pinilla, Nerea, additional, Whipple, Nicholas S, additional, André, Nicolas, additional, Hrusak, Ondrej, additional, Velasco Puyó, Pablo, additional, Zacasa Vargas, Pamela, additional, Olate Mellado, Paola, additional, Yola Gassant, Pascale, additional, Diaz Romero, Paulina, additional, De Santis, Raffaella, additional, Kebudi, Rejin, additional, Boranbayeva, Riza, additional, Vasquez, Roberto, additional, Segura, Romel A., additional, Rosado, Roy Enrique, additional, Gómez, Sandra, additional, Raimbault, Sandra, additional, Gunasekera, Sanjeeva, additional, Makkeyah, Sara M, additional, Buyukkapu Bay, Sema, additional, M Gómez, Sergio, additional, Bouttefroy, Séverine, additional, Islam, Shahnoor, additional, Abouelnaga, Sherif, additional, Torres, Silvio Fabio, additional, Cesaro, Simone, additional, Nunes, Sofia, additional, Rouxinol, Soraia, additional, Bhaumik, Sucharita, additional, Saliyeva, Symbat, additional, Inostroza, Tamara, additional, Velasquez, Thelma, additional, Hnin, Tint Myo, additional, Norén-Nyström, Ulrika, additional, Baretta, Valentina, additional, Jimenez-Antolinez, Yajaira Valentine, additional, Pérez Alonso, Vanesa, additional, Ayer Miller, Vanessa, additional, Gandemer, Virginie, additional, Lotero, Viviana, additional, Mishkova, Volha, additional, Gómez-García, Wendy, additional, Margaryan, Yeva, additional, and Syed, Yumna, additional

Published
2021
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20. Preventing transmission of infectious agents in the pediatric in-patients hematology–oncology setting: what is the role for non-pharmacological prophylaxis?

Author

Désirée Caselli, Simone Cesaro, Susanna Livadiotti, Ottavio Ziino, Olivia Paolicchi, Giulio Zanazzo, Giuseppe M. Milano, Maria Licciardello, Angelica Barone, Monica Cellini, De Santis Raffaella, Mareva Giacchino, Mario Renato Rossi, Maurizio Aricò, and Elio Castagnola

Subjects
Medicine, Pediatrics, RJ1-570
Abstract

Despite a continuous will to protect the immune compromised host from infections, evidence based indications for intervention by non-pharmacological toools are still lacking in oncology. Nevertheless, guidelines on standard precaution and trasmission base precaution are available. They may be important in order to reduce the risk of trasmission of infection in selected healthcare settings, such as the pediatric hematology-oncology wards. . AIEOP Centers agree that for children treated with chemotherapy both of these approaches should be implemented and vigorously enforced, while additional policies, including strict environmental isolation should be restricetd to patients with selected clinical conditions or complications.

Published
2011
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21. Prophylaxis With Trimethoprim/Sulfamethoxazole Is Not Necessary in Children With Solid Tumors Treated With Low–medium Intensity Chemotherapy

Author

Meazza, Cristina, primary, Galaverna, Federica, additional, Petris, Maria Grazia, additional, Zama, Daniele, additional, La Spina, Milena, additional, Muggeo, Paola, additional, Ziino, Ottavio, additional, Cellini, Monica, additional, Soncini, Elena, additional, Barone, Angelica, additional, De Santis, Raffaella, additional, Perruccio, Katia, additional, Mura, Rossella, additional, Pascale, Silvia, additional, Mercolini, Federico, additional, and Cesaro, Simone, additional

Published
2021
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22. Screening for SARS‐CoV‐2 infection in pediatric oncology patients during the epidemic peak in Italy

Author

Cesaro, Simone, primary, Compagno, Francesca, additional, Zama, Daniele, additional, Meneghello, Linda, additional, Giurici, Nagua, additional, Soncini, Elena, additional, Onofrillo, Daniela, additional, Mercolini, Federico, additional, Mura, Rossella, additional, Perruccio, Katia, additional, De Santis, Raffaella, additional, Colombini, Antonella, additional, Barone, Angelica, additional, Sainati, Laura, additional, Baretta, Valentina, additional, and Petris, Maria Grazia, additional

Published
2020
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24. Frequency of Bacteremia due to Carbapenemase-producing Enterobacteriaceae in Pediatric Hematology-Oncology Can Be Reduced by Measures of Hospital Infection Control.

Author

Caselli, Désirée, Colombini, Antonella, Zama, Daniele, Castagnola, Elio, Muggeo, Paola, La Spina, Milena, Perruccio, Katia, De Santis, Raffaella, Carraro, Francesca, Mercolini, Federico, Petris, Maria Grazia, Onofrillo, Daniela, Mura, Rossella, Barretta, Valentina, and Cesaro, Simone

Subjects
NOSOCOMIAL infections, INFECTION control, BACTEREMIA, ENTEROBACTERIACEAE, STENOTROPHOMONAS maltophilia, KLEBSIELLA infections
Abstract

Objectives: The spread of carbapenemase-producing Enterobacteriaceae (CPE) is an emerging problem in children undergoing cancer-directed chemotherapy. A previous Italian survey reported a threefold increase in CPE colonization rate and a fourfold increase of CPE bloodstream infections in a 2 year-observation time interval. Methods: To assess the efficacy of the measures put in place to control this emergency, a second survey was performed in the years 2016-2017 and the results were compared. Results: The overall rate of colonization was comparable between the two study periods: 0.50% (2016-2017) vs. 0.48% (2012-2013). MDR/CPE bacteremia was now reported in 13 children from six centers. The rate of MDR/CPE bacteremia was 0.12 for 1,000 days of hospitalization (95% CI, 0.07-0.21) and compared favorably with that observed in the previous survey (0.42 for 1,000 days of hospitalization; 95% CI, 0.31-0.57; p<0.0001). The strains responsible for bacteremia were Klebsiella pneumonia in 9/13 children, Escherichia coli in 2/13, Citrobacter spp. and Stenotrophomonas maltophilia in one case each. The antibiotic susceptibility was available for 10 MDR/CPE strains. Conclusion: The number of patients colonized by CPE remained stable over the years, while the number of bloodstream infections decreased, as well as the resulting mortality. We conclude that children undergoing chemotherapy are at risk for CPE colonization/infection but the awareness of their colonization status may allow reducing CPE morbidity and mortality. [ABSTRACT FROM AUTHOR]

Published
2021
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25. On the Output Regulation for Linear Systems in the Presence of Input Saturation

Author

De Santis, Raffaella and Isidori, Alberto

Subjects
Control engineering -- Innovations, Feedback (Electronics) -- Usage, Saturation (Electronics) -- Innovations
Abstract

Some new results on the problem of achieving output regulation in the presence of sinusoidal/constant exogenous signals for linear systems subject to input saturation are presented in this paper. In particular, the issue of enlarging the set of initial conditions for which the problem has solutions is addressed. Index Terms--Averaging, bounded controls, output feedback, regulator theory.

Published
2001

26. Guidelines on Vaccinations in Paediatric Haematology and Oncology Patients

Author

Cesaro, Simone, Giacchino, Mareva, Fioredda, Francesca, Barone, Angelica, Battisti, Laura, Bezzio, Stefania, Frenos, Stefano, De Santis, Raffaella, Livadiotti, Susanna, Marinello, Serena, Zanazzo, Andrea Giulio, and Caselli, Désirée

Subjects
Article Subject
Abstract

Objective. Vaccinations are the most important tool to prevent infectious diseases. Chemotherapy-induced immune depression may impact the efficacy of vaccinations in children. Patients and Methods. A panel of experts of the supportive care working group of the Italian Association Paediatric Haematology Oncology (AIEOP) addressed this issue by guidelines on vaccinations in paediatric cancer patients. The literature published between 1980 and 2013 was reviewed. Results and Conclusion. During intensive chemotherapy, vaccination turned out to be effective for hepatitis A and B, whilst vaccinations with toxoid, protein subunits, or bacterial antigens should be postponed to the less intensive phases, to achieve an adequate immune response. Apart from varicella, the administration of live-attenuated-virus vaccines is not recommended during this phase. Family members should remain on recommended vaccination schedules, including toxoid, inactivated vaccine (also poliomyelitis), and live-attenuated vaccines (varicella, measles, mumps, and rubella). By the time of completion of chemotherapy, insufficient serum antibody levels for vaccine-preventable diseases have been reported, while immunological memory appears to be preserved. Once immunological recovery is completed, usually after 6 months, response to booster or vaccination is generally good and allows patients to be protected and also to contribute to herd immunity.

Published
2014
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27. Disagreement between direct and indirect potentiometric Na+ determination in infancy and childhood.

Author

Milani, Gregorio P., Edefonti, Valeria, De Santis, Raffaella, Agostoni, Carlo, Spolidoro, Giulia C.I., Pelucchi, Claudio, Bianchetti, Mario G., and Fossali, Emilio F.

Subjects
UREA, COHEN'S kappa coefficient (Statistics), INFANTS
Abstract

We also found an association with the following pairwise interaction terms: age and creatinine, age and albumin, and finally hemoglobin and albumin. However, as albumin and creatinine vary with age [10], this analysis is not able to verify if albumin and creatinine play a direct or an indirect role in the mentioned associations. Age, albumin, hemoglobin, potentiometry, sodium. [Extracted from the article]

Published
2020
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29. Preventing transmission of infectious agents in the pediatric in-patients hematology–oncology setting: what is the role for non-pharmacological prophylaxis?

Author

Susanna Livadiotti, Giulio Andrea Zanazzo, Mareva Giacchino, De Santis Raffaella, Maurizio Aricò, Giuseppe Milano, Simone Cesaro, Mario Renato Rossi, Monica Cellini, Maria Licciardello, Elio Castagnola, Olivia Paolicchi, Désirée Caselli, Ottavio Ziino, and Angelica Barone

Subjects
medicine.medical_specialty, Pediatrics, Isolation (health care), chemotherapy, infections, leukemia, pediatrics, medicine.medical_treatment, lcsh:Medicine, Article, Intervention (counseling), medicine, Intensive care medicine, Non pharmacological, Chemotherapy, Transmission (medicine), business.industry, Risk of infection, lcsh:R, lcsh:RJ1-570, lcsh:Pediatrics, medicine.disease, Leukemia, business, Hematology+Oncology
Abstract

The most intensive chemotherapy regimens were used in the past for leukemia patients who were the main focus of trials on infections; today there are increasing numbers of children with solid cancer and considerable risk of infection who do receive intensive stand ard-dose chemotherapy. Despite a continuous will to protect the immune-compromised child from infections, evidence-based indications for intervention by non-pharmacological tools is still lacking in the pediatric hematology-oncology literature. Guidelines on standard precautions as well as precautions to avoid transmission of specific infectious agents are available. As a result of a consensus discussion, the Italian Association for Pediatric Hematology-Oncology (AIEOP) Cooperative Group centers agree that for children treated with chemotherapy both of these approaches should be implemented and vigorously enforced, while additional policies, including strict environmental isolation, should be restricted to patients with selected clinical conditions or complications. We present here a study by the working group on infectious diseases of AIEOP.

Published
2011

30. Fungal Infections in Children With Cancer

Author

Castagnola, Elio, primary, Cesaro, Simone, additional, Giacchino, Mareva, additional, Livadiotti, Susanna, additional, Tucci, Fabio, additional, Zanazzo, Giulio, additional, Caselli, Desirè, additional, Caviglia, Ilaria, additional, Parodi, Stefano, additional, Rondelli, Roberto, additional, Cornelli, Pier Emilo, additional, Mura, Rossella, additional, Santoro, Nicola, additional, Russo, Giovanna, additional, De Santis, Raffaella, additional, Buffardi, Salvatore, additional, Viscoli, Claudio, additional, Haupt, Riccardo, additional, and Rossi, Mario R., additional

Published
2006
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32. Ecthyma Gangrenosum in Children With Cancer: Diagnosis at a Glance: A Retrospective Study From the Infection Working Group of Italian Pediatric Hematology Oncology Association

Author

Nagua Giurici, Stefano Frenos, Milena La Spina, Raffaella De Santis, Daniele Zama, Paola Muggeo, Monica Ficara, Rosamaria Mura, Elisabetta Calore, Daniela Onofrillo, Antonella Colombini, Simone Cesaro, Nicola Santoro, Katia Perruccio, Nunzia Decembrino, Muggeo, Paola, Zama, Daniele, Decembrino, Nunzia, Onofrillo, Daniela, Frenos, Stefano, Colombini, Antonella, Perruccio, Katia, Calore, Elisabetta, Giurici, Nagua, Ficara, Monica, La Spina, Milena, Mura, Rosamaria, De Santis, Raffaella, Santoro, Nicola, and Cesaro, Simone

Subjects
Male, Microbiology (medical), medicine.medical_specialty, Neutropenia, Adolescent, Stenotrophomonas maltophilia, Pediatric Hematology/Oncology, Scars, Bacteremia, Ecthyma, Neoplasms, Internal medicine, Escherichia coli, medicine, Humans, Pseudomonas Infections, Child, Escherichia coli Infections, Retrospective Studies, biology, business.industry, Infant, Cancer, Retrospective cohort study, Hematology, biology.organism_classification, medicine.disease, Anti-Bacterial Agents, Ecthyma gangrenosum, Transplantation, Infectious Diseases, Italy, Child, Preschool, Pseudomonas aeruginosa, Pediatrics, Perinatology and Child Health, cthyma gangrenosum, children, Female, Neoplasm Recurrence, Local, medicine.symptom, business
Abstract

Background To depict ecthyma gangrenosum (EG) clinical presentation and evolution in a large multicenter pediatric retrospective collection of children with malignancies or bone marrow failure syndromes, to facilitate early diagnosis. Methods EG episodes diagnosed in the period 2009-2019 were identified by a retrospective review of clinical charts at centers belonging to the Italian Pediatric Hematology Oncology Association. Results Thirty-eight cases of EG occurring in children (male/female 16/22; median age 5.2 years) with hematologic malignancy (29), allogeneic stem cell transplantation (2) or relapsed/refractory solid tumor (3) were collected. The involved sites were: perineal region (19), limbs (10), trunk (6), head and the iliac crest (3). Bacteremia was present in 22 patients. Overall, the germs isolated were Pseudomonas aeruginosa (30), Stenotrophomonas maltophilia (3) and Escherichia coli (1); 31% of them were multidrug-resistant. All patients received antibacterial treatment, while surgery was performed in 24 patients (63.1%). Predisposing underlying conditions for EG were severe neutropenia (97.3%), corticosteroid treatment (71%) and iatrogenic diabetes (23.7%). All patients recovered, but EG recurred in 5 patients. Nine patients (24%) showed sequelae (deep scars, with muscle atrophy in 2). Four patients (10.5%) died, 1 due to relapse of EG with Carbapenem-resistant Enterobacteriaceae co-infection and 3 due to the progression of the underlying disease. Conclusions EG requires early recognition and a proper and timely treatment to obtain the recovery and to avoid larger necrotic lesions, eventually evolving in scarring sequelae.

Published
2022
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33. Favorable outcome of SARS-CoV-2 infection in pediatric hematology oncology patients during the second and third pandemic waves in Italy: a multicenter analysis from the Infectious Diseases Working Group of the Associazione Italiana di Ematologia e Oncologia Pediatrica (AIEOP)

Author

Daniele Zama, Francesco Baccelli, Antonella Colombini, Amalia Contino, Elisabetta Calore, Maria Grazia Petris, Linda Meneghello, Federico Mercolini, Andrea Lo Vecchio, Shana Montalto, Cristina Meazza, Angelica Barone, Francesca Compagno, Paola Muggeo, Elena Soncini, Letizia Brescia, Eugenia Giraldi, Nagua Giurici, Rosa Maria Mura, Monica Cellini, Katia Perruccio, Valeria Petroni, Milena La Spina, Ottavio Ziino, Roberta Burnelli, Raffaella De Santis, Maurizio Mascarin, Valentina Barretta, Gloria Tridello, Simone Cesaro, Zama, Daniele, Baccelli, Francesco, Colombini, Antonella, Contino, Amalia, Calore, Elisabetta, Petris, Maria Grazia, Meneghello, Linda, Mercolini, Federico, Lo Vecchio, Andrea, Montalto, Shana, Meazza, Cristina, Barone, Angelica, Compagno, Francesca, Muggeo, Paola, Soncini, Elena, Brescia, Letizia, Giraldi, Eugenia, Giurici, Nagua, Mura, Rosa Maria, Cellini, Monica, Perruccio, Katia, Petroni, Valeria, La Spina, Milena, Ziino, Ottavio, Burnelli, Roberta, De Santis, Raffaella, Mascarin, Maurizio, Barretta, Valentina, Tridello, Gloria, and Cesaro, Simone

Subjects
SARS-COV- 2 infection, SARS-CoV-2, COVID-19, Pediatric oncology, General Medicine, Hematology, Communicable Diseases, Italy, Neoplasms, Humans, RNA, Viral, Child, Children, Pandemics, Outcome
Abstract

COVID-19 has a mild clinical course with low mortality rate in general pediatric population, while variable outcomes have been described in children with cancer. Infectious diseases working party of the AIEOP collected data on the clinical characteristics and outcomes of SARS-CoV-2 infections in pediatric oncology/hematology patients from April 2020 to May 2021, including the second and the third waves of the pandemic in Italy. Factors potentially associated with moderate, severe, or critical COVID-19 were analyzed. Of the 153 SARS-Cov2 infections recorded, 100 were asymptomatic and 53 symptomatic. The course of COVID-19 was mild in 41, moderate in 2, severe in 5, and critical in 5 children. A total of 40.5% of patients were hospitalized, ten requiring oxygen support and 5 admitted to the intensive care unit. Antibiotics and steroids were the most used therapies. No patient died due to SARS-CoV-2 infection. Infections occurring early ( 60 days) or during maintenance therapy. In the patients on active chemotherapy, 59% withdrew the treatment for a median of 15 days. SARS-CoV-2 presented a favorable outcome in children with cancer in Italy during the pandemic. Modification of therapy represents a major concern in this population. Our findings suggest considering regular chemotherapy continuation, particularly in patients on maintenance therapy or infected late after the diagnosis.

Published
2022

34. Long-term health outcome and quality of life in children with multisystem inflammatory syndrome: findings from multidisciplinary follow-up at an Italian tertiary-care paediatric hospital.

Author

D'Auria E, Bova SM, Dallapiccola AR, De Santis R, Leone A, Calcaterra V, Mannarino S, Garbin M, Olivotto S, Zirpoli S, Ghezzi M, Munari AM, Verduci E, Farolfi A, Bosetti A, Perico V, Capetti P, Gadda A, Gianolio L, Lo Monaco G, Lonoce L, Previtali R, Serafini L, Taranto S, Veggiotti P, and Zuccotti G

Subjects
Humans, Child, Female, Male, Italy epidemiology, Follow-Up Studies, Adolescent, Child, Preschool, Hospitals, Pediatric, Tertiary Care Centers, COVID-19 psychology, COVID-19 complications, COVID-19 epidemiology, Systemic Inflammatory Response Syndrome epidemiology, Systemic Inflammatory Response Syndrome diagnosis, Quality of Life
Abstract

Multisystem inflammatory syndrome is a severe complication of SARS-CoV-2 infection in children (MIS-C). To date, data on long-term sequelae mainly concern cardiac outcomes. All ≤ 18 year olds consecutively admitted to the Buzzi Children's Hospital with a diagnosis of MIS-C between October 1, 2020, and May 31, 2022, were followed up for up to 12 months by a dedicated multidisciplinary team. They underwent laboratory tests, multi-organ clinical and instrumental assessments, and psychosocial evaluation. 56/62 patients, 40 M, mean age 8.7 years (95% CI 7.7, 9.7), completed the follow-up. Cardiological, gastroenterological, pneumological, and neurological evaluations, including IQ and EEG, were normal. Alterations of HOMA-IR index and/or TyG index, observed in almost all patients during hospitalisation, persisted in about a third of the population at 12 months. At 6 and 12 months respectively, impairment of adaptive functions was observed in 38/56 patients (67.9%) and 25/56 (44.6%), emotional and behavioural problems in 10/56 (17.9%) and 9/56 (16.1%), and decline in QoL in 14/56 (25.0%) and 9/56 (16.1%). Psychosocial well-being impairment was significantly more frequent in the subgroup with persistent glycometabolic dysfunction at 12 months (75% vs. 40.9% p < 0.001)., Conlusion: The mechanisms that might explain the long-term persistence of both metabolic alterations and neuro-behavioural outcomes and their possible relationship are far from being clarified. Our study points out to the potential long-term effects of pandemics and to the importance of a multidisciplinary follow-up to detect potential negative sequelae in different areas of health, both physical and psychosocial., What Is Known: • Multisystem inflammatory syndrome in children (MIS-C) is a severe complication of SARS-CoV-2 infection. • Few data exist on the medium- and long-term outcomes of MIS-C, mostly focused on cardiac involvement. Emerging evidence shows neurological and psychological sequelae at mid- and long-term follow-up., What Is New: • This study reveals that MIS-C may lead to long-term glycometabolic dysfunctions joined to impairment in the realm of general well-being and decline in quality of life, in a subgroup of children. • This study highlights the importance of a long-term multidisciplinary follow-up of children hospitalised with MIS-C, in order to detect the potential long-term sequelae in different areas of health, both physical and psychosocial well-being., (© 2024. The Author(s).)

Published
2024
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35. SARS-CoV-2 Infection in the Pediatric Oncology Population: The Definitive Comprehensive Report of the Infectious Diseases Working Group of AIEOP.

Author

Zama D, Zanaroli A, Corbelli A, Lo Vecchio A, Del Bene M, Colombini A, Compagno F, Barone A, Fontanili I, Rosaria D'Amico M, Papa MR, Petris MG, Calore E, Montalto S, Meneghello L, Brescia L, Mura R, La Spina M, Muggeo P, Rinieri S, Meazza C, Perruccio K, Cellini M, Spadea M, Mercolini F, Petroni V, De Santis R, Soncini E, Provenzi M, Giurici N, Ziino O, Tridello G, and Cesaro S

Subjects
Child, Humans, SARS-CoV-2, COVID-19, Neoplasms complications, Neoplasms therapy, Neoplasms epidemiology, Hematopoietic Stem Cell Transplantation adverse effects, Communicable Diseases
Abstract

Objective: The objective of this study was to assess the clinical impact and outcome of the SARS-CoV-2 infection on children with cancer or those who received a hematopoietic stem cell transplantation., Methods: AIEOP (Italian Association of Pediatric Hematology and Oncology) performed a nationwide multicenter observational cohort study, including consecutive patients between April 2020 and November 2022., Results: Twenty-five Italian centers participated and 455 patients were enrolled. We reported a significant increasing trend of symptomatic cases over the years, while the number of nonmild infections remained stable. Early infection after oncologic diagnosis (<60 days) and severe neutropenia were identified as independent risk factors for developing moderate, severe, or critical infections. The percentage of patients who were asymptomatic and mildly symptomatic and who stopped chemotherapy reduced over the years of the pandemic. Nine patients died, but no death was attributed to SARS-CoV-2 infection., Conclusions: SARS-CoV-2 infection presented a self-limiting benign course in the Italian pediatric oncohematology population during the pandemic, and its main consequence has been the discontinuation of cancer-directed therapies. The rate of patients who were asymptomatic and stopped chemotherapy reduced over the years, suggesting that the continuation of chemotherapy is a feasible option., Competing Interests: Potential conflicts of interest. All authors: No reported conflicts. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest., (© The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)

Published
2024
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37. A survey on hematology-oncology pediatric AIEOP centers: prophylaxis, empirical therapy and nursing prevention procedures of infectious complications.

Author

Livadiotti S, Milano GM, Serra A, Folgori L, Jenkner A, Castagnola E, Cesaro S, Rossi MR, Barone A, Zanazzo G, Nesi F, Licciardello M, De Santis R, Ziino O, Cellini M, Porta F, Caselli D, and Pontrelli G

Subjects
Anti-Infective Agents adverse effects, Anti-Infective Agents therapeutic use, Antibiotic Prophylaxis, Child, Communicable Diseases drug therapy, Communicable Diseases etiology, Communicable Diseases nursing, Hematologic Neoplasms nursing, Hematologic Neoplasms therapy, Hematopoietic Stem Cell Transplantation adverse effects, Humans, Surveys and Questionnaires, Communicable Disease Control, Hematologic Neoplasms complications
Abstract

A nationwide questionnaire-based survey was designed to evaluate the management and prophylaxis of febrile neutropenia in pediatric patients admitted to hematology-oncology and hematopoietic stem cell transplant units. Of the 34 participating centers, 40 and 63%, respectively, continue to prescribe antibacterial and antimycotic prophylaxis in low-risk subjects and 78 and 94% in transplant patients. Approximately half of the centers prescribe a combination antibiotic regimen as first-line therapy in low-risk patients and up to 81% in high-risk patients. When initial empirical therapy fails after seven days, 63% of the centers add empirical antimycotic therapy in low-and 81% in high-risk patients. Overall management varies significantly across centers. Preventive nursing procedures are in accordance with international guidelines. This survey is the first to focus on prescribing practices in children with cancer and could help to implement practice guidelines.

Published
2012
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