1. Blood concentrations of clobazam and norclobazam in a lethal case involving clobazam, meprobamate and clorazepate.
- Author
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Pok PR, Mauras M, De Saint Léger MN, Kuhlmann E, Charpenel-Durat C, Navarette C, Duval ML, and De Meo P
- Subjects
- Aged, Anticonvulsants poisoning, Autopsy, Benzodiazepines poisoning, Clobazam, Clorazepate Dipotassium poisoning, Drug Overdose, Fatal Outcome, Female, Humans, Meprobamate poisoning, Anticonvulsants blood, Benzodiazepines blood, Clorazepate Dipotassium blood, Meprobamate blood
- Abstract
Clobazam is a benzodiazepine with anti-anxiety and anticonvulsant properties marketed in several countries. Norclobazam, a metabolite of clobazam, has similar pharmacological activity but weaker sedative and tranquilizing effect. The two drugs were detected by GC-MS and determined by HPLC-DAD in the samples from a postmortem case. The femoral blood concentrations of clobazam and norclobazam were 0.72 and 36 μg/mL, respectively. The concentration of the active norclobazam was very high. The sum of both clobazam and norclobazam blood concentration (36.72 μg/mL) was clearly toxic, but was not necessarily fatal. Other associated drugs concentrations were within their therapeutic ranges. Interactions due to drug association were discussed., (Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.)
- Published
- 2010
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