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173 results on '"De Roeck, Ellen"'

1. Involvement of the choroid plexus in Alzheimer’s disease pathophysiology: findings from mouse and human proteomic studies

Author

Delvenne, Aurore, Vandendriessche, Charysse, Gobom, Johan, Burgelman, Marlies, Dujardin, Pieter, De Nolf, Clint, Tijms, Betty M., Teunissen, Charlotte E., Schindler, Suzanne E., Verhey, Frans, Ramakers, Inez, Martinez-Lage, Pablo, Tainta, Mikel, Vandenberghe, Rik, Schaeverbeke, Jolien, Engelborghs, Sebastiaan, De Roeck, Ellen, Popp, Julius, Peyratout, Gwendoline, Tsolaki, Magda, Freund-Levi, Yvonne, Lovestone, Simon, Streffer, Johannes, Bertram, Lars, Blennow, Kaj, Zetterberg, Henrik, Visser, Pieter Jelle, Vandenbroucke, Roosmarijn E., and Vos, Stephanie J. B.

Published
2024
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2. Rare variants in IFFO1, DTNB, NLRC3 and SLC22A10 associate with Alzheimer’s disease CSF profile of neuronal injury and inflammation

Author

Neumann, Alexander, Küçükali, Fahri, Bos, Isabelle, Vos, Stephanie J. B., Engelborghs, Sebastiaan, De Pooter, Tim, Joris, Geert, De Rijk, Peter, De Roeck, Ellen, Tsolaki, Magda, Verhey, Frans, Martinez-Lage, Pablo, Tainta, Mikel, Frisoni, Giovanni, Blin, Oliver, Richardson, Jill, Bordet, Régis, Scheltens, Philip, Popp, Julius, Peyratout, Gwendoline, Johannsen, Peter, Frölich, Lutz, Vandenberghe, Rik, Freund-Levi, Yvonne, Streffer, Johannes, Lovestone, Simon, Legido-Quigley, Cristina, ten Kate, Mara, Barkhof, Frederik, Strazisar, Mojca, Zetterberg, Henrik, Bertram, Lars, Visser, Pieter Jelle, van Broeckhoven, Christine, and Sleegers, Kristel

Published
2022
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4. Blood DNA methylomic signatures associated with CSF biomarkers of Alzheimer's disease in the EMIF‐AD study.

Author

Smith, Rebecca G., Pishva, Ehsan, Kouhsar, Morteza, Imm, Jennifer, Dobricic, Valerija, Johannsen, Peter, Wittig, Michael, Franke, Andre, Vandenberghe, Rik, Schaeverbeke, Jolien, Freund‐Levi, Yvonne, Frölich, Lutz, Scheltens, Philip, Teunissen, Charlotte E., Frisoni, Giovanni, Blin, Olivier, Richardson, Jill C., Bordet, Régis, Engelborghs, Sebastiaan, and de Roeck, Ellen

Abstract

INTRODUCTION: We investigated blood DNA methylation patterns associated with 15 well‐established cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) pathophysiology, neuroinflammation, and neurodegeneration. METHODS: We assessed DNA methylation in 885 blood samples from the European Medical Information Framework for Alzheimer's Disease (EMIF‐AD) study using the EPIC array. RESULTS: We identified Bonferroni‐significant differential methylation associated with CSF YKL‐40 (five loci) and neurofilament light chain (NfL; seven loci) levels, with two of the loci associated with CSF YKL‐40 levels correlating with plasma YKL‐40 levels. A co‐localization analysis showed shared genetic variants underlying YKL‐40 DNA methylation and CSF protein levels, with evidence that DNA methylation mediates the association between genotype and protein levels. Weighted gene correlation network analysis identified two modules of co‐methylated loci correlated with several amyloid measures and enriched in pathways associated with lipoproteins and development. DISCUSSION: We conducted the most comprehensive epigenome‐wide association study (EWAS) of AD‐relevant CSF biomarkers to date. Future work should explore the relationship between YKL‐40 genotype, DNA methylation, and protein levels in the brain. Highlights: Blood DNA methylation was assessed in the EMIF‐AD MBD study.Epigenome‐wide association studies (EWASs) were performed for 15 Alzheimer's disease (AD)–relevant cerebrospinal fluid (CSF) biomarker measures.Five Bonferroni‐significant loci were associated with YKL‐40 levels and seven with neurofilament light chain (NfL).DNA methylation in YKL‐40 co‐localized with previously reported genetic variation.DNA methylation potentially mediates the effect of single‐nucleotide polymorphisms (SNPs) in YKL‐40 on CSF protein levels. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Discovery and validation of plasma proteomic biomarkers relating to brain amyloid burden by SOMAscan assay

Author

Shi, Liu, Westwood, Sarah, Baird, Alison L., Winchester, Laura, Dobricic, Valerija, Kilpert, Fabian, Hong, Shengjun, Franke, Andre, Hye, Abdul, Ashton, Nicholas J., Morgan, Angharad R., Bos, Isabelle, Vos, Stephanie J.B., Buckley, Noel J., Kate, Mara ten, Scheltens, Philip, Vandenberghe, Rik, Gabel, Silvy, Meersmans, Karen, Engelborghs, Sebastiaan, De Roeck, Ellen E., Sleegers, Kristel, Frisoni, Giovanni B., Blin, Olivier, Richardson, Jill C., Bordet, Régis, Molinuevo, José L., Rami, Lorena, Wallin, Anders, Kettunen, Petronella, Tsolaki, Magda, Verhey, Frans, Lleó, Alberto, Alcolea, Daniel, Popp, Julius, Peyratout, Gwendoline, Martinez-Lage, Pablo, Tainta, Mikel, Johannsen, Peter, Teunissen, Charlotte E., Freund-Levi, Yvonne, Frölich, Lutz, Legido-Quigley, Cristina, Barkhof, Frederik, Blennow, Kaj, Zetterberg, Henrik, Baker, Susan, Morgan, B. Paul, Streffer, Johannes, Visser, Pieter Jelle, Bertram, Lars, Lovestone, Simon, and Nevado-Holgado, Alejo J.

Published
2019
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7. Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the European Medical Information Framework for Alzheimer's Disease biomarker discovery cohort

Author

Kim, Min, Snowden, Stuart, Suvitaival, Tommi, Ali, Ashfaq, Merkler, David J., Ahmad, Tahmina, Westwood, Sarah, Baird, Alison, Proitsi, Petroula, Nevado-Holgado, Alejo, Hye, Abdul, Bos, Isabelle, Vos, Stephanie, Vandenberghe, Rik, Teunissen, Charlotte, ten Kate, Mara, Scheltens, Philip, Gabel, Silvy, Meersmans, Karen, Blin, Olivier, Richardson, Jill, De Roeck, Ellen, Sleegers, Kristel, Bordet, Régis, Rami, Lorena, Kettunen, Petronella, Tsolaki, Magda, Verhey, Frans, Sala, Isabel, Lléo, Alberto, Peyratout, Gwendoline, Tainta, Mikel, Johannsen, Peter, Freund-Levi, Yvonne, Frölich, Lutz, Dobricic, Valerija, Engelborghs, Sebastiaan, Frisoni, Giovanni B., Molinuevo, José L., Wallin, Anders, Popp, Julius, Martinez-Lage, Pablo, Bertram, Lars, Barkhof, Frederik, Ashton, Nicholas, Blennow, Kaj, Zetterberg, Henrik, Streffer, Johannes, Visser, Pieter J., Lovestone, Simon, and Legido-Quigley, Cristina

Published
2019
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9. The frequency and influence of dementia risk factors in prodromal Alzheimer's disease

Author

Bos, Isabelle, Vos, Stephanie J., Frölich, Lutz, Kornhuber, Johannes, Wiltfang, Jens, Maier, Wolfgang, Peters, Oliver, Rüther, Eckhart, Engelborghs, Sebastiaan, Niemantsverdriet, Ellis, De Roeck, Ellen Elisa, Tsolaki, Magda, Freund-Levi, Yvonne, Johannsen, Peter, Vandenberghe, Rik, Lleó, Alberto, Alcolea, Daniel, Frisoni, Giovanni B., Galluzzi, Samantha, Nobili, Flavio, Morbelli, Silvia, Drzezga, Alexander, Didic, Mira, van Berckel, Bart N., Salmon, Eric, Bastin, Christine, Dauby, Solene, Santana, Isabel, Baldeiras, Inês, de Mendonça, Alexandre, Silva, Dina, Wallin, Anders, Nordlund, Arto, Coloma, Preciosa M., Wientzek, Angelika, Alexander, Myriam, Novak, Gerald P., Gordon, Mark Forrest, Wallin, Åsa K., Hampel, Harald, Soininen, Hilkka, Herukka, Sanna-Kaisa, Scheltens, Philip, Verhey, Frans R., and Visser, Pieter Jelle

Published
2017
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11. Blood-based multivariate methylation risk score for cognitive impairment and dementia

Author

Koetsier, Jarno, primary, Cavill, Rachel, additional, Reijnders, Rick A, additional, Harvey, Joshua, additional, Deckers, Kay, additional, Köhler, Sebastian, additional, Eijssen, Lars, additional, Smith, Rebecca G, additional, Smith, Adam R, additional, Burrage, Joe, additional, Walker, Emma M, additional, Shireby, Gemma, additional, Hannon, Eilis, additional, Dempster, Emma, additional, Frayling, Timothy, additional, Mill, Jonathan, additional, Dobricic, Valerija, additional, Sommerer, Yasmine, additional, Johannsen, Peter, additional, Wittig, Michael, additional, Franke, Andre, additional, Vandenberghe, Rick, additional, Schaeverbeke, Jolien, additional, Freund-Levi, Yvonne, additional, Frölich, Lutz, additional, Scheltens, Philip, additional, Teunissen, Charlotte, additional, Frisoni, Giovanni, additional, Blin, Olivier, additional, Richardson, Jill, additional, Bordet, Régis, additional, Engelborghs, Sebastiaan, additional, de Roeck, Ellen, additional, Martinez-Lage, Pablo, additional, Tainta, Mikel, additional, Lleó, Alberto, additional, Sala, Isabel, additional, Popp, Julius, additional, Peyratout, Gwedoline, additional, Verhey, Frans, additional, Tsolaki, Magda, additional, Andreasson, Ulf, additional, Blennow, Kaj, additional, Zetterberg, Henrik, additional, Streffer, Johannes, additional, Vos, Stephanie JB, additional, Lovestone, Simon, additional, Visser, Pieter-Jelle, additional, Bertram, Lars, additional, Lunnon, Katie, additional, and Pishva, Ehsan, additional

Published
2023
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12. Author Correction: Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

Author

de Rojas, Itziar, Moreno-Grau, Sonia, Tesi, Niccolo, Grenier-Boley, Benjamin, Andrade, Victor, Jansen, Iris E., Pedersen, Nancy L., Stringa, Najada, Zettergren, Anna, Hernández, Isabel, Antúnez, Carmen, Antonell, Anna, Tankard, Rick M., Bis, Joshua C., Sims, Rebecca, Bellenguez, Céline, Quintela, Inés, González-Perez, Antonio, Calero, Miguel, Macías, Juan, Blesa, Rafael, Cervera-Carles, Laura, Menéndez-González, Manuel, Royo, Jose Luís, Moreno, Fermin, Huerto Vilas, Raquel, Baquero, Miquel, Diez-Fairen, Mónica, Lage, Carmen, García-González, Pablo, Valero, Sergi, Ullgren, Abbe, Naj, Adam C., Lemstra, Afina W., Benussi, Alberto, Rábano, Alberto, Padovani, Alessandro, Squassina, Alessio, de Mendonça, Alexandre, Arias Pastor, Alfonso, Kok, Almar A. L., Meggy, Alun, Pastor, Ana Belén, Espinosa, Ana, Corma-Gómez, Anaïs, Sanabria, Ángela, DeStefano, Anita L., Schneider, Anja, Haapasalo, Annakaisa, Kinhult Ståhlbom, Anne, Tybjærg-Hansen, Anne, Hartmann, Annette M., Spottke, Annika, Corbatón-Anchuelo, Arturo, Rongve, Arvid, Borroni, Barbara, Arosio, Beatrice, Nacmias, Benedetta, Nordestgaard, Børge G., Kunkle, Brian W., Charbonnier, Camille, Masullo, Carlo, Martínez Rodríguez, Carmen, Muñoz-Fernandez, Carmen, Dufouil, Carole, Graff, Caroline, Ferreira, Catarina B., Chillotti, Caterina, Reynolds, Chandra A., Fenoglio, Chiara, Van Broeckhoven, Christine, Clark, Christopher, Pisanu, Claudia, Satizabal, Claudia L., Holmes, Clive, Buiza-Rueda, Dolores, Aarsland, Dag, Rujescu, Dan, Alcolea, Daniel, Galimberti, Daniela, Wallon, David, Seripa, Davide, Grünblatt, Edna, Dardiotis, Efthimios, Düzel, Emrah, Scarpini, Elio, Conti, Elisa, Rubino, Elisa, Gelpi, Ellen, Rodriguez-Rodriguez, Eloy, Duron, Emmanuelle, Boerwinkle, Eric, Ferri, Evelyn, Tagliavini, Fabrizio, Küçükali, Fahri, Pasquier, Florence, Sanchez-Garcia, Florentino, Mangialasche, Francesca, Jessen, Frank, Nicolas, Gaël, Selbæk, Geir, Ortega, Gemma, Chêne, Geneviève, Hadjigeorgiou, Georgios, Rossi, Giacomina, Spalletta, Gianfranco, Giaccone, Giorgio, Grande, Giulia, Binetti, Giuliano, Papenberg, Goran, Hampel, Harald, Bailly, Henri, Zetterberg, Henrik, Soininen, Hilkka, Karlsson, Ida K., Alvarez, Ignacio, Appollonio, Ildebrando, Giegling, Ina, Skoog, Ingmar, Saltvedt, Ingvild, Rainero, Innocenzo, Rosas Allende, Irene, Hort, Jakub, Diehl-Schmid, Janine, Van Dongen, Jasper, Vidal, Jean-Sebastien, Lehtisalo, Jenni, Wiltfang, Jens, Thomassen, Jesper Qvist, Kornhuber, Johannes, Haines, Jonathan L., Vogelgsang, Jonathan, Pineda, Juan A., Fortea, Juan, Popp, Julius, Deckert, Jürgen, Buerger, Katharina, Morgan, Kevin, Fließbach, Klaus, Sleegers, Kristel, Molina-Porcel, Laura, Kilander, Lena, Weinhold, Leonie, Farrer, Lindsay A., Wang, Li-San, Kleineidam, Luca, Farotti, Lucia, Parnetti, Lucilla, Tremolizzo, Lucio, Hausner, Lucrezia, Benussi, Luisa, Froelich, Lutz, Ikram, M. Arfan, Deniz-Naranjo, M. Candida, Tsolaki, Magda, Rosende-Roca, Maitée, Löwenmark, Malin, Hulsman, Marc, Spallazzi, Marco, Pericak-Vance, Margaret A., Esiri, Margaret, Bernal Sánchez-Arjona, María, Dalmasso, Maria Carolina, Martínez-Larrad, María Teresa, Arcaro, Marina, Nöthen, Markus M., Fernández-Fuertes, Marta, Dichgans, Martin, Ingelsson, Martin, Herrmann, Martin J., Scherer, Martin, Vyhnalek, Martin, Kosmidis, Mary H., Yannakoulia, Mary, Schmid, Matthias, Ewers, Michael, Heneka, Michael T., Wagner, Michael, Scamosci, Michela, Kivipelto, Miia, Hiltunen, Mikko, Zulaica, Miren, Alegret, Montserrat, Fornage, Myriam, Roberto, Natalia, van Schoor, Natasja M., Seidu, Nazib M., Banaj, Nerisa, Armstrong, Nicola J., Scarmeas, Nikolaos, Scherbaum, Norbert, Goldhardt, Oliver, Hanon, Oliver, Peters, Oliver, Skrobot, Olivia Anna, Quenez, Olivier, Lerch, Ondrej, Bossù, Paola, Caffarra, Paolo, Dionigi Rossi, Paolo, Sakka, Paraskevi, Mecocci, Patrizia, Hoffmann, Per, Holmans, Peter A., Fischer, Peter, Riederer, Peter, Yang, Qiong, Marshall, Rachel, Kalaria, Rajesh N., Mayeux, Richard, Vandenberghe, Rik, Cecchetti, Roberta, Ghidoni, Roberta, Frikke-Schmidt, Ruth, Sorbi, Sandro, Hägg, Sara, Engelborghs, Sebastiaan, Helisalmi, Seppo, Botne Sando, Sigrid, Kern, Silke, Archetti, Silvana, Boschi, Silvia, Fostinelli, Silvia, Gil, Silvia, Mendoza, Silvia, Mead, Simon, Ciccone, Simona, Djurovic, Srdjan, Heilmann-Heimbach, Stefanie, Riedel-Heller, Steffi, Kuulasmaa, Teemu, del Ser, Teodoro, Lebouvier, Thibaud, Polak, Thomas, Ngandu, Tiia, Grimmer, Timo, Bessi, Valentina, Escott-Price, Valentina, Giedraitis, Vilmantas, Deramecourt, Vincent, Maier, Wolfgang, Jian, Xueqiu, Pijnenburg, Yolande A. L., Smith, A. David, Saenz, Aldo, Bizzarro, Alessandra, Lauria, Alessandra, Vacca, Alessandro, Solomon, Alina, Anastasiou, Anna, Richardson, Anna, Boland, Anne, Koivisto, Anne, Daniele, Antonio, Greco, Antonio, Marianthi, Arnaoutoglou, McGuinness, Bernadette, Fin, Bertrand, Ferrari, Camilla, Custodero, Carlo, Ferrarese, Carlo, Ingino, Carlos, Mangone, Carlos, Reyes Toso, Carlos, Martínez, Carmen, Cuesta, Carolina, Muchnik, Carolina, Joachim, Catharine, Ortiz, Cecilia, Besse, Céline, Johansson, Charlotte, Zoia, Chiara Paola, Laske, Christoph, Anastasiou, Costas, Palacio, Dana Lis, Politis, Daniel G., Janowitz, Daniel, Craig, David, Mann, David M., Neary, David, Jürgen, Deckert, Daian, Delphine, Belezhanska, Diyana, Kohler, Eduardo, Castaño, Eduardo M., Koutsouraki, Effrosyni, Chipi, Elena, De Roeck, Ellen, Costantini, Emanuele, Vardy, Emma R. L. C., Piras, Fabrizio, Roveta, Fausto, Piras, Federica, Prestia, Federico Ariel, Assogna, Francesca, Salani, Francesca, Sala, Gessica, Lacidogna, Giordano, Novack, Gisela, Wilcock, Gordon, Thonberg, Håkan, Kölsch, Heike, Weber, Heike, Boecker, Henning, Etchepareborda, Ignacio, Piaceri, Irene, Tuomilehto, Jaakko, Lindström, Jaana, Laczo, Jan, Johnston, Janet, Deleuze, Jean-François, Harris, Jenny, Schott, Jonathan M., Priller, Josef, Bacha, Juan Ignacio, Snowden, Julie, Lisso, Julieta, Mihova, Kalina Yonkova, Traykov, Latchezar, Morelli, Laura, Brusco, Luis Ignacio, Rainer, Malik, Takalo, Mari, Bjerke, Maria, Del Zompo, Maria, Serpente, Maria, Sanchez Abalos, Mariana, Rios, Mario, Peltonen, Markku, Herrman, Martin J., Kohler, Matias, Rojo, Matias, Jones, Matthew, Orsini, Michela, Medel, Nancy, Olivar, Natividad, Fox, Nick C., Salvadori, Nicola, Hooper, Nigel M., Galeano, Pablo, Solis, Patricia, Bastiani, Patrizia, Passmore, Peter, Heun, Reinhard, Antikainen, Riitta, Olaso, Robert, Perneczky, Robert, Germani, Sandra, López-García, Sara, Love, Seth, Mehrabian, Shima, Bagnoli, Silvia, Kochen, Silvia, Andreoni, Simona, Teipel, Stefan, Todd, Stephen, Pickering-Brown, Stuart, Natunen, Teemu, Tegos, Thomas, Laatikainen, Tiina, Strandberg, Timo, Polvikoski, Tuomo M., Matoska, Vaclav, Ciullo, Valentina, Cores, Valeria, Solfrizzi, Vincenzo, Lisetti, Viviana, Sevillano, Zulma, Abdelnour, C., Aguilera, N., Alarcon, E., Alegret, M., Benaque, A., Boada, M., Buendia, M., Cañabate, P., Carracedo, A., de Rojas, I., Diego, S., Espinosa, A., Gailhajenet, A., García-González, P., Gil, S., Guitart, M., González-Pérez, A., Hernández, I., Ibarria, M., Lafuente, A., Macias, J., Maroñas, O., Martín, E., Martínez, M.T., Marquié, M., Mauleón, A., Montrreal, L., Moreno-Grau, S., Moreno, M., Orellana, A., Ortega, G., Pancho, A., Pelejá, E., Pérez-Cordon, A., Pineda, J.A., Preckler, S., Quintela, I., Real, L.M., Rosende-Roca, M., Ruiz, A., Sáez, M.E., Sanabria, A., Serrano-Rios, M., Sotolongo-Grau, O., Tárraga, L., Valero, S., Vargas, L., Adarmes-Gómez, A.D., Alarcón-Martín, E., Alonso, M.D., Álvarez, I., Álvarez, V., Amer-Ferrer, G., Antequera, M., Antúnez, C., Baquero, M., Bernal, M., Blesa, R., Bullido, M.J., Burguera, J.A., Calero, M., Carrillo, F., Carrión-Claro, M., Casajeros, M.J., Clarimón, J., Cruz-Gamero, J.M., de Pancorbo, M.M., del Ser, T., Diez-Fairen, M., Escuela, R., Garrote-Espina, L., Fortea, J., Franco-Macías, E., Frank-García, A., Garcia Madrona, S., Gómez-Garre, P., Hevilla, S., Jesús, S., Labrador Espinosa, M.A., Lage, C., Legaz, A., Lleó, A., Lopez de Munain, A., López-García, S., Macias-García, D., Manzanares, S., Marín, M., Marín-Muñoz, J., Marín, T., Martín Montes, A., Martínez, B., Martínez, C., Martínez, V., Martínez-Lage Álvarez, P., Medina, M., Mendioroz Iriarte, M., Menéndez-González, M., Mir, P., Molinuevo, J.L., Pastor, P., Pérez Tur, J., Periñán-Tocino, T., Pineda-Sanchez, R., Piñol-Ripoll, G., Rábano, A., Real de Asúa, D., Rodrigo, S., Rodríguez-Rodríguez, E., Royo, J.L., Sanchez del Valle Díaz, R., Sánchez-Juan, P., Sastre, I., Vicente, M.P., Vigo-Ortega, R., Vivancos, L., Macleod, C., McCracken, C., Brayne, Carol, Bresner, Catherine, Grozeva, Detelina, Bellou, Eftychia, Sommerville, Ewen W., Matthews, F., Leonenko, Ganna, Menzies, Georgina, Windle, Gill, Harwood, Janet, Phillips, Judith, Bennett, K., Luckuck, Lauren, Clare, Linda, Woods, Robert, Saad, Salha, Burholt, Vanessa, Kehoe, Patrick Gavin, Garcia-Ribas, Guillermo, Sánchez-Juan, Pascual, Pastor, Pau, Pérez-Tur, Jordi, Piñol-Ripoll, Gerard, Lopez de Munain, Adolfo, García-Alberca, Jose María, Bullido, María J., Álvarez, Victoria, Lleó, Alberto, Real, Luis M., Mir, Pablo, Medina, Miguel, Scheltens, Philip, Holstege, Henne, Marquié, Marta, Sáez, María Eugenia, Carracedo, Ángel, Amouyel, Philippe, Schellenberg, Gerard D., Williams, Julie, Seshadri, Sudha, van Duijn, Cornelia M., Mather, Karen A., Sánchez-Valle, Raquel, Serrano-Ríos, Manuel, Orellana, Adelina, Tárraga, Lluís, Blennow, Kaj, Huisman, Martijn, Andreassen, Ole A., Posthuma, Danielle, Clarimón, Jordi, Boada, Mercè, van der Flier, Wiesje M., Ramirez, Alfredo, Lambert, Jean-Charles, van der Lee, Sven J., Ruiz, Agustín, Smith, A David, Saenz, Aldo, Bizzarro, Alessandra, Lauria, Alessandra, Vacca, Alessandro, Solomon, Alina, Anastasiou, Anna, Richardson, Anna, Boland, Anne, Koivisto, Anne, Daniele, Antonio, Greco, Antonio, Marianthi, Arnaoutoglou, McGuinness, Bernadette, Fin, Bertrand, Ferrari, Camilla, Custodero, Carlo, Ferrarese, Carlo, Ingino, Carlos, Mangone, Carlos, Reyes Toso, Carlos, Martínez, Carmen, Cuesta, Carolina, Muchnik, Carolina, Joachim, Catharine, Ortiz, Cecilia, Besse, Céline, Johansson, Charlotte, Zoia, Chiara Paola, Laske, Christoph, Anastasiou, Costas, Palacio, Dana Lis, Politis, Daniel G, Janowitz, Daniel, Craig, David, Mann, David M, Neary, David, Jürgen, Deckert, Daian, Delphine, Belezhanska, Diyana, Kohler, Eduardo, Castaño, Eduardo M, Koutsouraki, Effrosyni, Chipi, Elena, De Roeck, Ellen, Costantini, Emanuele, Vardy, Emma R L C, Piras, Fabrizio, Roveta, Fausto, Piras, Federica, Prestia, Federico Ariel, Assogna, Francesca, Salani, Francesca, Sala, Gessica, Lacidogna, Giordano, Novack, Gisela, Wilcock, Gordon, Thonberg, Håkan, Kölsch, Heike, Weber, Heike, Boecker, Henning, Etchepareborda, Ignacio, Piaceri, Irene, Tuomilehto, Jaakko, Lindström, Jaana, Laczo, Jan, Johnston, Janet, Deleuze, Jean-François, Harris, Jenny, Schott, Jonathan M, Priller, Josef, Bacha, Juan Ignacio, Snowden, Julie, Lisso, Julieta, Mihova, Kalina Yonkova, Traykov, Latchezar, Morelli, Laura, Brusco, Luis Ignacio, Rainer, Malik, Takalo, Mari, Bjerke, Maria, Del Zompo, Maria, Serpente, Maria, Sanchez Abalos, Mariana, Rios, Mario, Peltonen, Markku, Herrman, Martin J, Kohler, Matias, Rojo, Matias, Jones, Matthew, Orsini, Michela, Medel, Nancy, Olivar, Natividad, Fox, Nick C, Salvadori, Nicola, Hooper, Nigel M, Galeano, Pablo, Solis, Patricia, Bastiani, Patrizia, Passmore, Peter, Heun, Reinhard, Antikainen, Riitta, Olaso, Robert, Perneczky, Robert, Germani, Sandra, López-García, Sara, Love, Seth, Mehrabian, Shima, Bagnoli, Silvia, Kochen, Silvia, Andreoni, Simona, Teipel, Stefan, Todd, Stephen, Pickering-Brown, Stuart, Natunen, Teemu, Tegos, Thomas, Laatikainen, Tiina, Strandberg, Timo, Polvikoski, Tuomo M, Matoska, Vaclav, Ciullo, Valentina, Cores, Valeria, Solfrizzi, Vincenzo, Lisetti, Viviana, Sevillano, Zulma, Abdelnour, C., Aguilera, N., Alarcon, E., Alegret, M., Benaque, A., Boada, M., Buendia, M., Cañabate, P., Carracedo, A., Corbatón-Anchuelo, A., de Rojas, I., Diego, S., Espinosa, A., Gailhajenet, A., García-González, P., Gil, S., Guitart, M., González-Pérez, A., Hernández, I., Ibarria, M., Lafuente, A., Macias, J., Maroñas, O., Martín, E., Martínez, M. T., Marquié, M., Mauleón, A., Montrreal, L., Moreno-Grau, S., Moreno, M., Orellana, A., Ortega, G., Pancho, A., Pelejá, E., Pérez-Cordon, A., Pineda, J. A., Preckler, S., Quintela, I., Real, L. M., Rosende-Roca, M., Ruiz, A., Sáez, M. E., Sanabria, A., Serrano-Rios, M., Sotolongo-Grau, O., Tárraga, L., Valero, S., Vargas, L., Adarmes-Gómez, A. D., Alarcón-Martín, E., Alonso, M. D., Álvarez, I., Álvarez, V., Amer-Ferrer, G., Antequera, M., Antúnez, C., Baquero, M., Bernal, M., Blesa, R., Buiza-Rueda, D., Bullido, M. J., Burguera, J. A., Calero, M., Carrillo, F., Carrión-Claro, M., Casajeros, M. J., Clarimón, J., Cruz-Gamero, J. M., de Pancorbo, M. M., Del Ser, T., Diez-Fairen, M., Escuela, R., Garrote-Espina, L., Fortea, J., Franco-Macías, E., Frank-García, A., García-Alberca, J. M., Garcia Madrona, S., Garcia-Ribas, G., Gómez-Garre, P., Hevilla, S., Jesús, S., Labrador Espinosa, M. A., Lage, C., Legaz, A., Lleó, A., Lopez de Munain, A., López-García, S., Macias-García, D., Manzanares, S., Marín, M., Marín-Muñoz, J., Marín, T., Martín Montes, A., Martínez, B., Martínez, C., Martínez, V., Martínez-Lage Álvarez, P., Medina, M., Mendioroz Iriarte, M., Menéndez-González, M., Mir, P., Molinuevo, J. L., Pastor, P., Pérez Tur, J., Periñán-Tocino, T., Pineda-Sanchez, R., Piñol-Ripoll, G., Rábano, A., Real de Asúa, D., Rodrigo, S., Rodríguez-Rodríguez, E., Royo, J. L., Sanchez Del Valle Díaz, R., Sánchez-Juan, P., Sastre, I., Vicente, M. P., Vigo-Ortega, R., Vivancos, L., Macleod, C., McCracken, C., Brayne, Carol, Bresner, Catherine, Grozeva, Detelina, Bellou, Eftychia, Sommerville, Ewen W, Matthews, F., Leonenko, Ganna, Menzies, Georgina, Windle, Gill, Harwood, Janet, Phillips, Judith, Bennett, K., Luckuck, Lauren, Clare, Linda, Woods, Robert, Saad, Salha, Burholt, Vanessa, Rongve, Arvid, Brussels Heritage Lab, Clinical sciences, Neuroprotection & Neuromodulation, and Neurology

Subjects
polygenic risk scores, Multidisciplinary, Common variants, Neuroscience(all), neurology, Medizin, General Physics and Astronomy, ddc:500, General Chemistry, Alzheimer's disease, General Biochemistry, Genetics and Molecular Biology, RISK STRATIFICATION
Abstract

The original version of this Article omitted from the author list the 212th author Patrizia Mecocci, who is from the Institute of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy. Consequently, the “Sample Contribution” section of Author Contributions was updated to add “P.M” between “P.D.” and “R.C.”. Additionally, the original version of this Article contained the incorrect affiliation for author Patrick Gavin Kehoe, which incorrectly read “German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany”. The correct version replaces this affiliation with “Bristol Medical School (THS), University of Bristol, Southmead Hospital, Bristol, UK”. This has been corrected in both the PDF and HTML versions of the Article. CA extern

Published
2023
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13. Whole-exome rare-variant analysis of Alzheimer's disease and related biomarker traits

Author

Küçükali, Fahri, Neumann, Alexander, Van Dongen, Jasper, De Pooter, Tim, Joris, Geert, De Rijk, Peter, Ohlei, Olena, Dobricic, Valerija, Bos, Isabelle, Vos, Stephanie J.B., Engelborghs, Sebastiaan, De Roeck, Ellen, Vandenberghe, Rik, Gabel, Silvy, Meersmans, Karen, Tsolaki, Magda, Verhey, Frans, Martinez-Lage, Pablo, Tainta, Mikel, Frisoni, Giovanni, Blin, Oliver, Richardson, Jill C., Bordet, Régis, Scheltens, Philip, Popp, Julius, Peyratout, Gwendoline, Johannsen, Peter, Frölich, Lutz, Freund-Levi, Yvonne, Streffer, Johannes, Lovestone, Simon, Legido-Quigley, Cristina, Kate, Mara ten, Barkhof, Frederik, Zetterberg, Henrik, Bertram, Lars, Strazisar, Mojca, Visser, Pieter Jelle, Van Broeckhoven, Christine, Sleegers, Kristel, Küçükali, Fahri, Neumann, Alexander, Van Dongen, Jasper, De Pooter, Tim, Joris, Geert, De Rijk, Peter, Ohlei, Olena, Dobricic, Valerija, Bos, Isabelle, Vos, Stephanie J.B., Engelborghs, Sebastiaan, De Roeck, Ellen, Vandenberghe, Rik, Gabel, Silvy, Meersmans, Karen, Tsolaki, Magda, Verhey, Frans, Martinez-Lage, Pablo, Tainta, Mikel, Frisoni, Giovanni, Blin, Oliver, Richardson, Jill C., Bordet, Régis, Scheltens, Philip, Popp, Julius, Peyratout, Gwendoline, Johannsen, Peter, Frölich, Lutz, Freund-Levi, Yvonne, Streffer, Johannes, Lovestone, Simon, Legido-Quigley, Cristina, Kate, Mara ten, Barkhof, Frederik, Zetterberg, Henrik, Bertram, Lars, Strazisar, Mojca, Visser, Pieter Jelle, Van Broeckhoven, Christine, and Sleegers, Kristel

Abstract

Introduction: Despite increasing evidence of a role of rare genetic variation in the risk of Alzheimer's disease (AD), limited attention has been paid to its contribution to AD-related biomarker traits indicative of AD-relevant pathophysiological processes. Methods: We performed whole-exome gene-based rare-variant association studies (RVASs) of 17 AD-related traits on whole-exome sequencing (WES) data generated in the European Medical Information Framework for Alzheimer's Disease Multimodal Biomarker Discovery (EMIF-AD MBD) study (n = 450) and whole-genome sequencing (WGS) data from ADNI (n = 808). Results: Mutation screening revealed a novel probably pathogenic mutation (PSEN1 p.Leu232Phe). Gene-based RVAS revealed the exome-wide significant contribution of rare coding variation in RBKS and OR7A10 to cognitive performance and protection against left hippocampal atrophy, respectively. Discussion: The identification of these novel gene–trait associations offers new perspectives into the role of rare coding variation in the distinct pathophysiological processes culminating in AD, which may lead to identification of novel therapeutic and diagnostic targets.

Published
2023

14. Whole‐exome rare‐variant analysis of Alzheimer's disease and related biomarker traits

Author

Alzheimer's Disease Neuroimaging Initiative (ADNI), Küçükali, Fahri, Neumann, Alexander, Van Dongen, Jasper, De Pooter, Tim, Joris, Geert, De Rijk, Peter, Ohlei, Olena, Dobricic, Valerija, Bos, Isabelle, Vos, Stephanie J B, Engelborghs, Sebastiaan, De Roeck, Ellen, Vandenberghe, Rik, Gabel, Silvy, Meersmans, Karen, Tsolaki, Magda, Verhey, Frans, Martinez-Lage, Pablo, Tainta, Mikel, Frisoni, Giovanni, Blin, Oliver, Richardson, Jill C, Bordet, Régis, Scheltens, Philip, Popp, Julius, Peyratout, Gwendoline, Johannsen, Peter, Frölich, Lutz, Freund-Levi, Yvonne, Streffer, Johannes, Lovestone, Simon, Legido-Quigley, Cristina, Kate, Mara Ten, Barkhof, Frederik, Zetterberg, Henrik, Bertram, Lars, Strazisar, Mojca, Visser, Pieter Jelle, Van Broeckhoven, Christine, Sleegers, Kristel, Alzheimer’s Disease Neuroimaging Initiative (ADNI), EMIF-ADStudyGroup, Epidemiology, Psychiatrie & Neuropsychologie, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, Clinical sciences, Neuroprotection & Neuromodulation, Neurology, Amsterdam Neuroscience - Neurodegeneration, Radiology and nuclear medicine, Amsterdam Neuroscience - Brain Imaging, and Amsterdam Neuroscience - Neuroinfection & -inflammation

Subjects
D-RIBOSE, Epidemiology, Endophenotypes, Neuroscience(all), Clinical Neurology, ABCA7, Cellular and Molecular Neuroscience, Developmental Neuroscience, SDG 3 - Good Health and Well-being, GWAS, whole-exome sequencing, GENOME-WIDE ASSOCIATION, METAANALYSIS, Science & Technology, ENDOPHENOTYPES, MUTATIONS, Health Policy, neurology, biomarkers, rare coding variants, Alzheimer's disease, FRAMEWORK, Psychiatry and Mental health, Whole-exome sequencing, COGNITIVE DECLINE, Neurology (clinical), Neurosciences & Neurology, Human medicine, Geriatrics and Gerontology, Life Sciences & Biomedicine
Abstract

INTRODUCTION: Despite increasing evidence of a role of rare genetic variation in the risk of Alzheimer's disease (AD), limited attention has been paid to its contribution to AD-related biomarker traits indicative of AD-relevant pathophysiological processes. METHODS: We performed whole-exome gene-based rare-variant association studies (RVASs) of 17 AD-related traits on whole-exome sequencing (WES) data generated in the European Medical Information Framework for Alzheimer's Disease Multimodal Biomarker Discovery (EMIF-AD MBD) study (n = 450) and whole-genome sequencing (WGS) data from ADNI (n = 808). RESULTS: Mutation screening revealed a novel probably pathogenic mutation (PSEN1 p.Leu232Phe). Gene-based RVAS revealed the exome-wide significant contribution of rare coding variation in RBKS and OR7A10 to cognitive performance and protection against left hippocampal atrophy, respectively. DISCUSSION: The identification of these novel gene-trait associations offers new perspectives into the role of rare coding variation in the distinct pathophysiological processes culminating in AD, which may lead to identification of novel therapeutic and diagnostic targets. ispartof: ALZHEIMERS & DEMENTIA vol:19 issue:6 ispartof: location:United States status: Published online

Published
2023
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16. Randomized controlled trial to evaluate a prevention program for frail community-dwelling older adults: a D-SCOPE protocol

Author

Lambotte, Deborah, De Donder, Liesbeth, De Roeck, Ellen E., Hoeyberghs, Lieve J., van der Vorst, Anne, Duppen, Daan, Van der Elst, Michaël, Fret, Bram, Dury, Sarah, Smetcoren, An-Sofie, Kardol, Martinus J. M., Engelborghs, Sebastiaan, De Deyn, Peter Paul, De Witte, Nico, Schols, Jos M. G. A., Kempen, Gertrudis I. J. M., Zijlstra, G. A. Rixt, De Lepeleire, Jan, Schoenmakers, Birgitte, Verté, Dominique, and Dierckx, Eva

Published
2018
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19. Focusing on positive outcomes in frailty research

Author

Duppen, Daan, Rossi, Gina, Dierckx, Eva, Hoeyberghs, Lieve, De Donder, Liesbeth, Smetcoren, A-S., Dury, S., De Witte, N., Lambotte, D., Fret, B., Duppen, D., Kardol, M., Verte, D., De Roeck, Ellen, Engelborghs, Sebastiaan, De Deyn, Peter Paul, Van der Elst, M. C. J., De Lepeleire, J., Schoenmakers, B., van der Vorst, A., Zijlstra, G. A. R., Kempen, G. I. J. M., Schols, J. M. G. A., RS: CAPHRI - R1 - Ageing and Long-Term Care, Promovendi PHPC, Health Services Research, RS: Academische Werkplaats Ouderenzorg, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, Educational Science, Psychology, Brain, Body and Cognition, Personality and Psychopathology, Psychopathology and Information Processing in Older Adults, Clinical and Lifespan Psychology, Metajuridica, Faculty of Psychology and Educational Sciences, Belgian Ageing Studies, Brussels research center for Innovation in Learning and Diversity, and D-SCOPE Consortium

Subjects
Male, Psychometrics, gerontology, Frail Elderly, Clinical psychology, QUESTIONNAIRE, Sample (statistics), Structural equation modeling, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, well-being, PEOPLE, Surveys and Questionnaires, Item response theory, Humans, Psychology, health outcomes, Aged, Aged, 80 and over, 030214 geriatrics, short form, Reproducibility of Results, Life satisfaction, item response theory, RANDOMIZED CONTROLLED-TRIAL, Outcome (probability), Confirmatory factor analysis, LIFE, Psychiatry and Mental health, Cross-Sectional Studies, Well-being, Quality of Life, Female, Human medicine, Geriatrics and Gerontology, Factor Analysis, Statistical, INTEGRATION, 030217 neurology & neurosurgery
Abstract

Objective:Studies of frailty have tended to focus on adverse outcomes. This study aims to develop a short instrument that identifies a positive outcome, namely, the level of well-being in older adults at risk of frailty.Method:871 older adults (49.4% women; mean age 75.72 years; SD = 8.05) with a frailty risk profile participated in the first wave of the D-SCOPE study. The possible domains of well-being were identified using a bottom-up approach. Exploratory Structural Equation Modeling (ESEM) and multidimensional Item Response Theory (IRT) analysis of 17 items in 4 domains measuring well-being was performed on a calibration sample (n = 435) to develop the instrument. The instrument was subsequently corroborated by confirmatory factor analysis and convergent/divergent relations with relevant external measures in a validation sample (n = 436).Results:The ESEM three-factor solution, with the subdimensions of sense of mastery, meaning in life, and life satisfaction, displayed good fit to the data (RMSEA = 0.070). For each dimension, the three best discriminating items were retained for the instrument following IRT analysis. Internal consistency of these dimensions was good in the validation sample (sense of mastery α = 0.864, meaning in life α = 0.715, and life satisfaction α = 0.782). The confirmatory factor analysis (CFA) three-factor model also showed good fit to the data (RMSEA = 0.064). Small to large zero-order correlations with the external measures were as expected.Conclusions:Using a bottom-up approach, this study developed a short instrument to identify levels of well-being in vulnerable or frail older adults. The instrument can be applied in primary care and prevention programs.

Published
2019
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20. Relational aspects of mastery for frail, older adults

Author

Lambotte, Deborah, Kardol, Martinus J. M., Schoenmakers, Birgitte, Fret, Bram, Smetcoren, A-S, De Roeck, Ellen E., Van der Elst, Michael, De Donder, Liesbeth, Dury, S., Dierckx, E., Duppen, D., Verte, D., Hoeyberghs, L. J., De Witte, N., Engelborghs, S., De Deyn, P. P., De Lepeleire, J., van der Vorst, A., Zijlstra, G. A. R., Kempen, G. I. J. M., Schols, J. M. G. A., D‐SCOPE Consortium, Faculty of Psychology and Educational Sciences, Educational Science, Faculty of Economic and Social Sciences and Solvay Business School, Belgian Ageing Studies, Brussels research center for Innovation in Learning and Diversity, RS: CAPHRI - R1 - Ageing and Long-Term Care, Promovendi PHPC, Health Services Research, RS: Academische Werkplaats Ouderenzorg, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, and Family Medicine

Subjects
Male, Gerontology, Care process, PERCEPTIONS, Sociology and Political Science, Frail Elderly, media_common.quotation_subject, Decision Making, Frail Older Adults, PARTICIPATION, Interviews as Topic, 03 medical and health sciences, 0302 clinical medicine, Sociology, PEOPLE, Secondary analysis, SUPPORT, SOCIAL CARE, Humans, 030212 general & internal medicine, HOME, Everyday life, Empowerment, Competence (human resources), older adults, Aged, media_common, Aged, 80 and over, INDEPENDENCE, 030503 health policy & services, Public Health, Environmental and Occupational Health, CENTERED CARE, Middle Aged, Health policy, EXPERIENCES, Integrated care, informal care, Caregivers, HEALTH-CARE, Female, relational aspects of mastery, Independent Living, Human medicine, secondary analysis, 0305 other medical science, Psychology, Social Sciences (miscellaneous), qualitative research, Qualitative research
Abstract

Frail, older care recipients are often thought of as individuals with a decreased mastery of everyday life skills. Various authors have proposed to acknowledge a relational dimension of mastery, defined as the ability to maintain control over one's life with the help of others. This study explores how frail, older adults experience relational aspects of mastery and the role of their informal caregivers in maintaining these aspects of mastery over the care process. Qualitative interviews (N = 121) were conducted in 2016 with potentially frail, community‐dwelling older adults participating in the Detection, Support and Care for Older people: Prevention and Empowerment (D‐SCOPE) project. A secondary analysis of 65 interviews reveals that, according to frail, older adults, informal caregivers contribute in various ways to the preservation of their mastery. This differs across the four elements of care: caring about (attentiveness), taking care of (responsibility), care‐giving (competence), and care‐receiving (responsiveness). However, in some cases, older adults experienced a loss of mastery; for example, when informal caregivers did not understand their care needs and did not involve them in the decision, organisation, and provision of care. A relational dimension of mastery needs to be acknowledged in frail, older care recipients since stimulating mastery is a crucial element for realising community care objectives and person‐centred and integrated care.

Published
2019
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21. Sex-specific metabolic pathways associate with Alzheimer’s Disease (AD) endophenotypes in the European Medical Information Framework for AD Multimodal Biomarker Discovery cohort

Author

Xu, Jin, primary, Green, Rebecca, additional, Kim, Min, additional, Lord, Jodie, additional, Ebshiana, Amera, additional, Westwood, Sarah, additional, Baird, Alison L, additional, Nevado-Holgado, Alejo J, additional, Shi, Liu, additional, Hye, Abdul, additional, Snowden, Stuart G., additional, Bos, Isabelle, additional, Vos, Stephanie J. B., additional, Vandenberghe, Rik, additional, Teunissen, Charlotte E., additional, Kate, Mara Ten, additional, Scheltens, Philip, additional, Gabel, Silvy, additional, Meersmans, Karen, additional, Blin, Olivier, additional, Richardson, Jill, additional, De Roeck, Ellen Elisa, additional, Engelborghs, Sebastiaan, additional, Sleegers, Kristel, additional, Bordet, Régis, additional, Rami, Lorena, additional, Kettunen, Petronella, additional, Tsolaki, Magda, additional, Verhey, Frans R.J., additional, Alcolea, Daniel, additional, Lleó, Alberto, additional, Peyratout, Gwendoline, additional, Tainta, Mikel, additional, Johannsen, Peter, additional, Freund-Levi, Yvonne, additional, Frölich, Lutz, additional, Dobricic, Valerija, additional, Frisoni, Giovanni B., additional, Molinuevo, José Luis, additional, Wallin, Anders, additional, Popp, Julius, additional, Martinez-Lage, Pablo, additional, Bertram, Lars, additional, Blennow, Kaj, additional, Zetterberg, Henrik, additional, Streffer, Johannes, additional, Visser, Pieter Jelle, additional, Lovestone, Simon, additional, Proitsi, Petroula, additional, and Legido-Quigley, Cristina, additional

Published
2021
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22. Replication study of plasma proteins relating to Alzheimer's pathology

Author

Shi, Liu, primary, Winchester, Laura M., additional, Westwood, Sarah, additional, Baird, Alison L., additional, Anand, Sneha N., additional, Buckley, Noel J, additional, Hye, Abdul, additional, Ashton, Nicholas J., additional, Bos, Isabelle, additional, Vos, Stephanie J. B., additional, Kate, Mara ten, additional, Scheltens, Philip, additional, Teunissen, Charlotte E., additional, Vandenberghe, Rik, additional, Gabel, Silvy, additional, Meersmans, Karen, additional, Engelborghs, Sebastiaan, additional, De Roeck, Ellen E., additional, Sleegers, Kristel, additional, Frisoni, Giovanni B., additional, Blin, Olivier, additional, Richardson, Jill C., additional, Bordet, Régis, additional, Molinuevo, José L., additional, Rami, Lorena, additional, Wallin, Anders, additional, Kettunen, Petronella, additional, Tsolaki, Magda, additional, Verhey, Frans, additional, Lléo, Alberto, additional, Sala, Isabel, additional, Popp, Julius, additional, Peyratout, Gwendoline, additional, Martinez‐Lage, Pablo, additional, Tainta, Mikel, additional, Johannsen, Peter, additional, Freund‐Levi, Yvonne, additional, Frölich, Lutz, additional, Dobricic, Valerija, additional, Legido‐Quigley, Cristina, additional, Barkhof, Frederik, additional, Andreasson, Ulf, additional, Blennow, Kaj, additional, Zetterberg, Henrik, additional, Streffer, Johannes, additional, Lill, Christina M., additional, Bertram, Lars, additional, Visser, Pieter Jelle, additional, Kolb, Hartmuth C., additional, Narayan, Vaibhav A., additional, Lovestone, Simon, additional, and Nevado‐Holgado, Alejo J., additional

Published
2021
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23. Identification of plasma proteome signatures associated with ATN framework using SOMAscan

Author

Shi, Liu, primary, Westwood, Sarah, additional, Baird, Alison L., additional, Buckley, Noel, additional, Dobricic, Valerija, additional, Kilpert, Fabian, additional, Hong, Shengjun, additional, Franke, Andreas, additional, Hye, Abdul, additional, Ashton, Nicholas J., additional, Morgan, Angharad, additional, Bos, Isabelle, additional, Vos, Stephanie J.B., additional, ten Kate, Mara, additional, Scheltens, Philip, additional, Vandenberghe, Rik, additional, Gabel, Silvy, additional, Meersmans, Karen, additional, Engelborghs, Sebastiaan, additional, De Roeck, Ellen Elisa, additional, Sleegers, Kristel, additional, Frisoni, Giovanni B., additional, Blin, Olivier, additional, Richardson, Jill, additional, Bordet, Régis, additional, Molinuevo, Jose Luis, additional, Rami, Lorena, additional, Wallin, Anders, additional, Kettunen, Petronella, additional, Tsolaki, Magda, additional, Verhey, Frans R.J., additional, Lleó, Alberto, additional, Alcolea, Daniel, additional, Popp, Julius, additional, Peyratout, Gwendoline, additional, Martinez‐Lage, Pablo, additional, Tainta, Mikel, additional, Johannsen, Peter, additional, Teunissen, Charlotte E, additional, Frölich, Lutz, additional, Freund, Yvonne, additional, Legido‐Quigley, Cristina, additional, Barkhof, Frederik, additional, Blennow, Kaj, additional, Zetterberg, Henrik, additional, Morgan, Paul, additional, Streffer, Johannes, additional, Visser, Pieter Jelle, additional, Bertram, Lars, additional, Lovestone, Simon, additional, Nevado‐Holgado, Alejo J, additional, and Winchester, Laura, additional

Published
2020
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24. Dickkopf-1 Overexpression in vitro Nominates Candidate Blood Biomarkers Relating to Alzheimer’s Disease Pathology

Author

Shi, Liu, primary, Winchester, Laura M., additional, Liu, Benjamine Y., additional, Killick, Richard, additional, Ribe, Elena M., additional, Westwood, Sarah, additional, Baird, Alison L., additional, Buckley, Noel J., additional, Hong, Shengjun, additional, Dobricic, Valerija, additional, Kilpert, Fabian, additional, Franke, Andre, additional, Kiddle, Steven, additional, Sattlecker, Martina, additional, Dobson, Richard, additional, Cuadrado, Antonio, additional, Hye, Abdul, additional, Ashton, Nicholas J., additional, Morgan, Angharad R., additional, Bos, Isabelle, additional, Vos, Stephanie J.B., additional, ten Kate, Mara, additional, Scheltens, Philip, additional, Vandenberghe, Rik, additional, Gabel, Silvy, additional, Meersmans, Karen, additional, Engelborghs, Sebastiaan, additional, De Roeck, Ellen E., additional, Sleegers, Kristel, additional, Frisoni, Giovanni B., additional, Blin, Olivier, additional, Richardson, Jill C., additional, Bordet, Régis, additional, Molinuevo, José L., additional, Rami, Lorena, additional, Wallin, Anders, additional, Kettunen, Petronella, additional, Tsolaki, Magda, additional, Verhey, Frans, additional, Lleó, Alberto, additional, Alcolea, Daniel, additional, Popp, Julius, additional, Peyratout, Gwendoline, additional, Martinez-Lage, Pablo, additional, Tainta, Mikel, additional, Johannsen, Peter, additional, Teunissen, Charlotte E., additional, Freund-Levi, Yvonne, additional, Frölich, Lutz, additional, Legido-Quigley, Cristina, additional, Barkhof, Frederik, additional, Blennow, Kaj, additional, Rasmussen, Katrine Laura, additional, Nordestgaard, Børge Grønne, additional, Frikke-Schmidt, Ruth, additional, Nielsen, Sune Fallgaard, additional, Soininen, Hilkka, additional, Vellas, Bruno, additional, Kloszewska, Iwona, additional, Mecocci, Patrizia, additional, Zetterberg, Henrik, additional, Morgan, B. Paul, additional, Streffer, Johannes, additional, Visser, Pieter Jelle, additional, Bertram, Lars, additional, Nevado-Holgado, Alejo J., additional, and Lovestone, Simon, additional

Published
2020
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25. F-18-FDG PET, the early phases and the delivery rate of F-18-AV45 PET as proxies of cerebral blood flow in Alzheimer's disease: Validation against O-15-H2O PET

Author

Ottoy, Julie, Verhaeghe, Jeroen, Niemantsverdriet, Ellis, De Roeck, Ellen, Wyffels, Leonie, Ceyssens, Sarah, Van Broeckhoven, Christine, Engelborghs, Sebastiaan, Stroobants, Sigrid, Staelens, Steven, Clinical sciences, and Neurology

Subjects
Medicine(all), Dual-phase PET, perfusion imaging, (18)F-AV45, Alzheimer's disease, Early-phase PET, Cerebral blood flow, R1, (18)F-FDG, (15)O-H(2)O
Abstract

INTRODUCTION: Dual-biomarker positron emission tomography (PET), providing complementary information on cerebral blood flow and amyloid-β deposition, is of clinical interest for Alzheimer's disease (AD). The purpose of this study was to validate the perfusion components of early-phase 18F-florbetapir (eAV45), the 18F-AV45 delivery rate (R1), and 18F-FDG against 15O-H2O PET and assess how they change with disease severity. METHODS: This study included ten controls, 19 amnestic mild cognitive impairment, and 10 AD dementia subjects. Within-subject regional correlations between modalities, between-group regional and voxel-wise analyses of covariance per modality, and receiver operating characteristic analyses for discrimination between groups were performed. RESULTS: FDG standardized uptake value ratio, eAV45 (0-2 min) standardized uptake value ratio, and AV45-R1 were significantly associated with H2O PET (regional Pearson r = 0.54-0.82, 0.70-0.94, and 0.65-0.92, respectively; P < .001). All modalities confirmed reduced cerebral blood flow in the posterior cingulate of patients with amnestic mild cognitive impairment and AD dementia, which was associated with lower cognition (r = 0.36-0.65, P < .025) and could discriminate between patient and control groups (area under the curve > 0.80). However, eAV45 was less sensitive to reflect the disease severity than AV45-R1 or FDG. DISCUSSION: R1 is preferable over eAV45 for accurate representation of brain perfusion in dual-biomarker PET for AD.

Published
2019

26. A metabolite-based machine learning approach to diagnose Alzheimer-type dementia in blood: Results from the European Medical Information Framework for Alzheimer disease biomarker discovery cohort

Author

Stamate, Daniel, Kim, Min, Proitsi, Petroula, Westwood, Sarah, Baird, Alison, Nevado-Holgado, Alejo, Hye, Abdul, Bos, Isabelle, Vos, Stephanie J.B., Vandenberghe, Rik, Teunissen, Charlotte E., Kate, Mara Ten, Scheltens, Philip, Gabel, Silvy, Meersmans, Karen, Blin, Olivier, Richardson, Jill, De Roeck, Ellen, Engelborghs, Sebastiaan, Sleegers, Kristel, Bordet, Régis, Ramit, Lorena, Kettunen, Petronella, Tsolaki, Magda, Verhey, Frans, Alcolea, Daniel, Lléo, Alberto, Peyratout, Gwendoline, Tainta, Mikel, Johannsen, Peter, Freund-Levi, Yvonne, Frölich, Lutz, Dobricic, Valerija, Frisoni, Giovanni B., Molinuevo, José L., Wallin, Anders, Popp, Julius, Martinez-Lage, Pablo, Bertram, Lars, Blennow, Kaj, Zetterberg, Henrik, Streffer, Johannes, Visser, Pieter J., Lovestone, Simon, and Legido-Quigley, Cristina

Published
2019
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27. Dickkopf-1 Overexpression in vitro Nominates Candidate Blood Biomarkers Relating to Alzheimer's Disease Pathology

Author

Shi, Liu, Winchester, Laura M., Liu, Benjamine Y., Killick, Richard, Ribe, Elena M., Westwood, Sarah, Baird, Alison L., Buckley, Noel J., Hong, Shengjun, Dobricic, Valerija, Kilpert, Fabian, Franke, Andre, Kiddle, Steven, Sattlecker, Martina, Dobson, Richard, Cuadrado, Antonio, Hye, Abdul, Ashton, Nicholas J., Morgan, Angharad R., Bos, Isabelle, Vos, Stephanie J.B., Ten Kate, Mara, Scheltens, Philip, Vandenberghe, Rik, Gabel, Silvy, Meersmans, Karen, Engelborghs, Sebastiaan, De Roeck, Ellen E., Sleegers, Kristel, Frisoni, Giovanni B., Blin, Olivier, Richardson, Jill C., Bordet, Régis, Molinuevo, José L., Rami, Lorena, Wallin, Anders, Kettunen, Petronella, Tsolaki, Magda, Verhey, Frans, Lleó, Alberto, Alcolea, Daniel, Popp, Julius, Peyratout, Gwendoline, Martinez-Lage, Pablo, Tainta, Mikel, Johannsen, Peter, Teunissen, Charlotte E., Freund-Levi, Yvonne, Frölich, Lutz, Legido-Quigley, Cristina, Barkhof, Frederik, Blennow, Kaj, Rasmussen, Katrine Laura, Nordestgaard, Børge Grønne, Frikke-Schmidt, Ruth, Nielsen, Sune Fallgaard, Soininen, Hilkka, Vellas, Bruno, Kloszewska, Iwona, Mecocci, Patrizia, Zetterberg, Henrik, Morgan, B. Paul, Streffer, Johannes, Visser, Pieter Jelle, Bertram, Lars, Nevado-Holgado, Alejo J., Lovestone, Simon, Shi, Liu, Winchester, Laura M., Liu, Benjamine Y., Killick, Richard, Ribe, Elena M., Westwood, Sarah, Baird, Alison L., Buckley, Noel J., Hong, Shengjun, Dobricic, Valerija, Kilpert, Fabian, Franke, Andre, Kiddle, Steven, Sattlecker, Martina, Dobson, Richard, Cuadrado, Antonio, Hye, Abdul, Ashton, Nicholas J., Morgan, Angharad R., Bos, Isabelle, Vos, Stephanie J.B., Ten Kate, Mara, Scheltens, Philip, Vandenberghe, Rik, Gabel, Silvy, Meersmans, Karen, Engelborghs, Sebastiaan, De Roeck, Ellen E., Sleegers, Kristel, Frisoni, Giovanni B., Blin, Olivier, Richardson, Jill C., Bordet, Régis, Molinuevo, José L., Rami, Lorena, Wallin, Anders, Kettunen, Petronella, Tsolaki, Magda, Verhey, Frans, Lleó, Alberto, Alcolea, Daniel, Popp, Julius, Peyratout, Gwendoline, Martinez-Lage, Pablo, Tainta, Mikel, Johannsen, Peter, Teunissen, Charlotte E., Freund-Levi, Yvonne, Frölich, Lutz, Legido-Quigley, Cristina, Barkhof, Frederik, Blennow, Kaj, Rasmussen, Katrine Laura, Nordestgaard, Børge Grønne, Frikke-Schmidt, Ruth, Nielsen, Sune Fallgaard, Soininen, Hilkka, Vellas, Bruno, Kloszewska, Iwona, Mecocci, Patrizia, Zetterberg, Henrik, Morgan, B. Paul, Streffer, Johannes, Visser, Pieter Jelle, Bertram, Lars, Nevado-Holgado, Alejo J., and Lovestone, Simon

Published
2020

28. Validation of Plasma Proteomic Biomarkers Relating to Brain Amyloid Burden in the EMIF-Alzheimer's Disease Multimodal Biomarker Discovery Cohort

Author

Westwood, Sarah, Baird, Alison L., Anand, Sneha N., Nevado-Holgado, Alejo J., Kormilitzin, Andrey, Shi, Liu, Hye, Abdul, Ashton, Nicholas J., Morgan, Angharad R., Bos, Isabelle, Vos, Stephanie J. B., Baker, Susan, Buckley, Noel J., Ten Kate, Mara, Scheltens, Philip, Teunissen, Charlotte E., Vandenberghe, Rik, Gabel, Silvy, Meersmans, Karen, Engelborghs, Sebastiaan, De Roeck, Ellen E., Sleegers, Kristel, Frisoni, Giovanni B., Blin, Olivier, Richardson, Jill C., Bordet, Régis, Molinuevo, José L., Rami, Lorena, Wallin, Anders, Kettunen, Petronella, Tsolaki, Magda, Verhey, Frans, Lléo, Alberto, Sala, Isabel, Popp, Julius, Peyratout, Gwendoline, Martinez-Lage, Pablo, Tainta, Mikel, Johannsen, Peter, Freund-Levi, Yvonne, Frölich, Lutz, Dobricic, Valerija, Legido-Quigley, Cristina, Bertram, Lars, Barkhof, Frederik, Zetterberg, Henrik, Morgan, B. Paul, Streffer, Johannes, Visser, Pieter Jelle, Lovestone, Simon, Westwood, Sarah, Baird, Alison L., Anand, Sneha N., Nevado-Holgado, Alejo J., Kormilitzin, Andrey, Shi, Liu, Hye, Abdul, Ashton, Nicholas J., Morgan, Angharad R., Bos, Isabelle, Vos, Stephanie J. B., Baker, Susan, Buckley, Noel J., Ten Kate, Mara, Scheltens, Philip, Teunissen, Charlotte E., Vandenberghe, Rik, Gabel, Silvy, Meersmans, Karen, Engelborghs, Sebastiaan, De Roeck, Ellen E., Sleegers, Kristel, Frisoni, Giovanni B., Blin, Olivier, Richardson, Jill C., Bordet, Régis, Molinuevo, José L., Rami, Lorena, Wallin, Anders, Kettunen, Petronella, Tsolaki, Magda, Verhey, Frans, Lléo, Alberto, Sala, Isabel, Popp, Julius, Peyratout, Gwendoline, Martinez-Lage, Pablo, Tainta, Mikel, Johannsen, Peter, Freund-Levi, Yvonne, Frölich, Lutz, Dobricic, Valerija, Legido-Quigley, Cristina, Bertram, Lars, Barkhof, Frederik, Zetterberg, Henrik, Morgan, B. Paul, Streffer, Johannes, Visser, Pieter Jelle, and Lovestone, Simon

Abstract

We have previously investigated, discovered, and replicated plasma protein biomarkers for use to triage potential trials participants for PET or cerebrospinal fluid measures of Alzheimer's disease (AD) pathology. This study sought to undertake validation of these candidate plasma biomarkers in a large, multi-center sample collection. Targeted plasma analyses of 34 proteins with prior evidence for prediction of in vivo pathology were conducted in up to 1,000 samples from cognitively healthy elderly individuals, people with mild cognitive impairment, and in patients with AD-type dementia, selected from the EMIF-AD catalogue. Proteins were measured using Luminex xMAP, ELISA, and Meso Scale Discovery assays. Seven proteins replicated in their ability to predict in vivo amyloid pathology. These proteins form a biomarker panel that, along with age, could significantly discriminate between individuals with high and low amyloid pathology with an area under the curve of 0.74. The performance of this biomarker panel remained consistent when tested in apolipoprotein E ɛ4 non-carrier individuals only. This blood-based panel is biologically relevant, measurable using practical immunocapture arrays, and could significantly reduce the cost incurred to clinical trials through screen failure.

Published
2020
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30. Validation of Plasma Proteomic Biomarkers Relating to Brain Amyloid Burden in the EMIF-Alzheimer’s Disease Multimodal Biomarker Discovery Cohort

Author

Westwood, Sarah, primary, Baird, Alison L., additional, Anand, Sneha N., additional, Nevado-Holgado, Alejo J., additional, Kormilitzin, Andrey, additional, Shi, Liu, additional, Hye, Abdul, additional, Ashton, Nicholas J., additional, Morgan, Angharad R., additional, Bos, Isabelle, additional, Vos, Stephanie J.B., additional, Baker, Susan, additional, Buckley, Noel J., additional, Ten Kate, Mara, additional, Scheltens, Philip, additional, Teunissen, Charlotte E., additional, Vandenberghe, Rik, additional, Gabel, Silvy, additional, Meersmans, Karen, additional, Engelborghs, Sebastiaan, additional, De Roeck, Ellen E., additional, Sleegers, Kristel, additional, Frisoni, Giovanni B., additional, Blin, Olivier, additional, Richardson, Jill C., additional, Bordet, Régis, additional, Molinuevo, José L., additional, Rami, Lorena, additional, Wallin, Anders, additional, Kettunen, Petronella, additional, Tsolaki, Magda, additional, Verhey, Frans, additional, Lléo, Alberto, additional, Sala, Isabel, additional, Popp, Julius, additional, Peyratout, Gwendoline, additional, Martinez-Lage, Pablo, additional, Tainta, Mikel, additional, Johannsen, Peter, additional, Freund-Levi, Yvonne, additional, Frölich, Lutz, additional, Dobricic, Valerija, additional, Legido-Quigley, Cristina, additional, Bertram, Lars, additional, Barkhof, Frederik, additional, Zetterberg, Henrik, additional, Morgan, B. Paul, additional, Streffer, Johannes, additional, Visser, Pieter Jelle, additional, and Lovestone, Simon, additional

Published
2020
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31. 18F-FDG PET, the early phases and the delivery rate of18F-AV45 PET as proxies of cerebral blood flow in Alzheimer's disease: Validation against15O-H2O PET

Author

Ottoy, Julie, primary, Verhaeghe, Jeroen, additional, Niemantsverdriet, Ellis, additional, De Roeck, Ellen, additional, Wyffels, Leonie, additional, Ceyssens, Sarah, additional, Van Broeckhoven, Christine, additional, Engelborghs, Sebastiaan, additional, Stroobants, Sigrid, additional, and Staelens, Steven, additional

Published
2019
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32. Exploring Cognitive Frailty: Prevalence and Associations with Other Frailty Domains in Older People with Different Degrees of Cognitive Impairment.

Author

De Roeck, Ellen E., van der Vorst, Anne, Engelborghs, Sebastiaan, Zijlstra, G.A. Rixt, Dierckx, Eva, De Roeck, Ellen E, van der Vorst, Anne, Zijlstra, G A Rixt, and D-SCOPE Consortium

Subjects
*COGNITION disorders, *OLDER people, *LONELINESS, *MONTREAL Cognitive Assessment, *AFFECTIVE disorders, *MILD cognitive impairment, *ABUSE of older people, *RESEARCH, *CROSS-sectional method, *RESEARCH methodology, *COGNITION, *GERIATRIC assessment, *EVALUATION research, *MEDICAL cooperation, *COMPARATIVE studies, *DISEASE prevalence, *INDEPENDENT living
Abstract

Background: Cognitive frailty has long been defined as the co-occurrence of mild cognitive deficits and physical frailty. However, recently, a new approach to cognitive frailty has been proposed: cognitive frailty as a distinct construct. Nonetheless, the relationship between this relatively new construct of cognitive frailty and other frailty domains is unclear.Objectives: The aims of this study were to explore the prevalence of cognitive frailty in groups with different degrees of cognitive impairment, as well as to explore the associations between frailty domains, and if this varies with level of objective cognitive impairment.Method: Cross-sectional, secondary data from 3 research projects among community-dwelling people aged ≥60 years, with different degrees of objective cognitive impairment, were used: (1) a randomly selected sample (n = 353); (2) a sample at an increased risk of frailty (n = 95); and (3) a sample of memory clinic patients who scored 0.5 on the Clinical Dementia Rating scale - according to the "original" definition of cognitive frailty (n = 47). Multidimensional frailty was assessed with the Comprehensive Frailty Assessment Instrument - Plus and general cognitive functioning with the Montreal Cognitive Assessment. Descriptive statistics and linear regression were used to determine the prevalence of cognitive frailty and to explore the relationship between cognitive frailty and the other types of frailty in each sample.Results: The prevalence of cognitive frailty increased along with the degree of objective cognitive impairment in the 3 samples (range 35.1-80.9%), while its co-occurrence with (one of) the other types of frailty was most frequent in the frail and community samples. Regarding its relationship with the other domains, cognitive frailty was positively associated with psychological frailty's subdomain mood disorder symptoms in all 3 samples (p ≤ 0.01), while there was no significant association with environmental frailty and social loneliness. The associations between cognitive frailty and the other types of frailty differed between the samples.Conclusion: Psychological and cognitive frailty are strongly associated, irrespective of the objective degree of cognitive impairment. In addition, it is shown that cognitive frailty can occur independently from the other frailty domains, including physical frailty, and therefore it can be seen as a distinct concept. [ABSTRACT FROM AUTHOR]

Published
2020
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33. Rare variants in IFFO1, DTNB, NLRC3and SLC22A10associate with Alzheimer’s disease CSF profile of neuronal injury and inflammation

Author

Neumann, Alexander, Küçükali, Fahri, Bos, Isabelle, Vos, Stephanie J. B., Engelborghs, Sebastiaan, De Pooter, Tim, Joris, Geert, De Rijk, Peter, De Roeck, Ellen, Tsolaki, Magda, Verhey, Frans, Martinez-Lage, Pablo, Tainta, Mikel, Frisoni, Giovanni, Blin, Oliver, Richardson, Jill, Bordet, Régis, Scheltens, Philip, Popp, Julius, Peyratout, Gwendoline, Johannsen, Peter, Frölich, Lutz, Vandenberghe, Rik, Freund-Levi, Yvonne, Streffer, Johannes, Lovestone, Simon, Legido-Quigley, Cristina, ten Kate, Mara, Barkhof, Frederik, Strazisar, Mojca, Zetterberg, Henrik, Bertram, Lars, Visser, Pieter Jelle, van Broeckhoven, Christine, and Sleegers, Kristel

Abstract

Alzheimer’s disease (AD) biomarkers represent several neurodegenerative processes, such as synaptic dysfunction, neuronal inflammation and injury, as well as amyloid pathology. We performed an exome-wide rare variant analysis of six AD biomarkers (β-amyloid, total/phosphorylated tau, NfL, YKL-40, and Neurogranin) to discover genes associated with these markers. Genetic and biomarker information was available for 480 participants from two studies: EMIF-AD and ADNI. We applied a principal component (PC) analysis to derive biomarkers combinations, which represent statistically independent biological processes. We then tested whether rare variants in 9576 protein-coding genes associate with these PCs using a Meta-SKAT test. We also tested whether the PCs are intermediary to gene effects on AD symptoms with a SMUT test. One PC loaded on NfL and YKL-40, indicators of neuronal injury and inflammation. Four genes were associated with this PC: IFFO1, DTNB, NLRC3,and SLC22A10. Mediation tests suggest, that these genes also affect dementia symptoms via inflammation/injury. We also observed an association between a PC loading on Neurogranin, a marker for synaptic functioning, with GABBR2and CASZ1, but no mediation effects. The results suggest that rare variants in IFFO1, DTNB, NLRC3,and SLC22A10heighten susceptibility to neuronal injury and inflammation, potentially by altering cytoskeleton structure and immune activity disinhibition, resulting in an elevated dementia risk. GABBR2and CASZ1were associated with synaptic functioning, but mediation analyses suggest that the effect of these two genes on synaptic functioning is not consequential for AD development.

Published
2022
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34. Validation of replacement questions for slowness and weakness to assess the Fried Phenotype: a cross-sectional study.

Author

Van der Elst, Michael C. J., Schoenmakers, Birgitte, Op het Veld, Linda P. M., De Roeck, Ellen E., Van der Vorst, Anne, Schols, Jos M. G. A., De Lepeleire, Jan, and Kempen, Gertrudis I. J. M.

Abstract

Key summary points: Aim: What is the overall concordance between FRIED-P and FRIED-Q? Findings: The concordance between the FRIED-P and FRIED-Q was substantial, characterized by a very high specificity but a moderate sensitivity. Message: The FRIED-Q can be used as a step in a sequential process to detect frailty in a large population. Purpose: When screening large populations, performance-based measures can be difficult to conduct because they are time consuming and costly, and require well-trained assessors. The aim of the present study is to validate a set of questions replacing the performance-based measures slowness and weakness as part of the Fried frailty phenotype (FRIED-P). Methods: A cross-sectional study was conducted among community-dwelling older adults (≥ 60 years) in three Flemish municipalities. The Fried Phenotype (FRIED-P) was used to measure physical frailty. The two performance-based measures of the Fried Phenotype (slowness and weakness) were also measured by means of six substituting questions (FRIED-Q). These questions were validated through sensitivity, specificity, Cohen's kappa value, observed agreement, correlation analysis, and the area under the curve (AUC, ROC curve). Results: 196 older adults participated. According to the FRIED-P, 19.5% of them were frail, 56.9% were pre-frail and 23.6% were non-frail. For slowness, the observed sensitivity was 47.0%, the specificity was 96.5% and the AUC was 0.717. For weakness, the sensitivity was 46.2%, the specificity was 83.7%, and the AUC was 0.649. The overall Spearman correlation between the FRIED-P and the FRIED-Q was r = 0.721 with an observed agreement of 76.6% (weighted linear kappa value = 0.663, quadratic kappa value = 0.738). Conclusions: The concordance between the FRIED-P and FRIED-Q was substantial, characterized by a very high specificity, but a moderate sensitivity. This alternative operationalization of the Fried Phenotype—i.e., including six replacement questions instead of two performance-based tests—can be considered to apply as screening tool to screen physical frailty in large populations. [ABSTRACT FROM AUTHOR]

Published
2020
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35. Exploring the Cost of 'Ageing in Place': Expenditures of Community-Dwelling Older Adults in Belgium.

Author

Fret, Bram, Mondelaers, Britt, De Donder, Liesbeth, Switsers, Lise, Smetcoren, An-Sofie, Verté, Dominique, the D-SCOPE consortium, Dury, Sarah, Dierckx, Eva, Lambotte, Deborah, Duppen, Daan, Kardol, Martinus, Hoeyberghs, Lieve, De Witte, Nico, De Roeck, Ellen, Engelborghs, Sebastiaan, De Deyn, Peter Paul, Van der Elst, Michaël, De Lepeleire, Jan, and Schoenmakers, Birgitte

Subjects
OLDER people, OLDER women, ADULTS, RESIDENTIAL care
Abstract

This paper aims to give an overview of the different sources of income and the expenditures of community-dwelling older adults and to what extent they can make ends meet to explore the affordability of care and support at home. Despite research on the affordability of residential care, evidence on the cost of 'ageing in place' is still missing. 173 questionnaires were gathered within a non-random sample of community-dwelling older adults (60+). Both frequencies and bivariate tests (to explore whether there are certain risk groups with low incomes and high expenditures) were performed on the data. Results indicate the variety of income sources, the necessity of financial compensations to make ends meet and that especially older women and older tenants are at risk for facing financial difficulties. Also, this research indicates that 'ageing in place', especially for older adults with care needs, is not always affordable and can be a challenge within our ageing society. [ABSTRACT FROM AUTHOR]

Published
2020
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36. PREVALENCE OF VASCULAR RISK FACTORS IN DIFFERENT STAGES OF PRODROMAL ALZHEIMER’S DISEASE AND ITS INFLUENCE ON COGNITIVE DECLINE

Author

Bos, Isabelle, Vos, Stephanie J.B., Frölich, Lutz, Kornhuber, Johannes, Wiltfang, Jens, Maier, Wolfgang, Peters, Oliver, Rüther, Eckhart, Engelborghs, Sebastiaan, Niemantsverdriet, Ellis, De Roeck, Ellen Elisa, Tsolaki, Magda, Freund-Levi, Yvonne, Johannsen, Peter, Vandenberghe, Rik, Lleó, Alberto, Alcolea, Daniel, Frisoni, Giovanni B., Galluzzi, Samantha, Nobili, Flavio, Morbelli, Silvia, Drzezga, Alexander, Didic, Mira, van Berckel, Bart N.M., Salmon, Eric, Bastin, Christine, Dauby, Solene, Santana, Isabel, Baldeiras, Inês, Mendonça, Alexandre, Silva, Dina, Wallin, Anders, Nordlund, Arto, Foskett, Nadia, Coloma, Preciosa, Alexander, Myriam, Wientzek-Fleischmann, Angelika, Nevado-Holgado, Alejo, Gungabissoon, Usha, Novak, Gerald P., Gordon, Mark Forrest, Wallin, Åsa K., Hampel, Harald, Soininen, Hilkka, Scheltens, Philip, Verhey, Frans R.J., and Visser, Pieter Jelle

Published
2016
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38. Dementie

Author

Marien, Peter, De Roeck, Ellen, Goossens, Joery, Luyckx, Jill, Niemandtsverdriet, Ellis, Somers, Charisse, Struyfs, Hanne, Engelborghs, Sebastiaan, Baumans, Rudy, Gillis, Katrin, Observerende Klinische wetenschappen, and Neurologie

Subjects
Medicine(all), demention, neurodegenerative brain diseases, Alzheimer's disease
Published
2017

39. Brein & zorg : dé verpleegkundige uitdaging

Author

Marien, Peter, De Roeck, Ellen, De Roeck, Naomi, Goossens, Joery, Luyckx, Jill, Niemantsverdriet, Ellis, Somers, Charisse, Struyfs, Hanne, Engelborghs, Sebastiaan, Centrum voor Linguistiek, Taal- en Letterkunde, Faculteit Psychologie en Educatieve wetenschappen, Observerende Klinische wetenschappen, and Neurologie

Published
2017

40. Vroegdiagnose van Alzheimer

Author

De Roeck, Ellen, Engelborghs, Sebastiaan, Observerende Klinische wetenschappen, and Neurologie

Subjects
Medicine(all), Human medicine, Alzheimer's disease, diagnose
Abstract

Door vooruitgang in het wetenschappelijke onderzoek naar biomarkers van de ziekte van Alzheimer, zijn we in staat om deze ziekte vroeg vast te stellen, zelfs in de lange preklinische fase waarin er geen ziektesymptomen zijn. Dit biedt belangrijke kansen naar preventie toe. Moet populatiescreening naar de ziekte van Alzheimer overwogen worden? Populatiescreening naar de ziekte van Alzheimer is vooralsnog niet aan de orde, in de eerste plaats omdat er nog geen medicijnen ter beschikking zijn die de ziekte effectief kunnen afremmen of voorkomen. Door het gebruik van biomarkers kunnen we de ziekte vaststellen in een zeer vroeg en zelfs preklinisch stadium, maar door de kostprijs en / of het relatieve invasieve karakter van deze onderzoeken is een toepassing als screeningsinstrument uitgesloten. Alhoewel de ziekte van Alzheimer een ongeneeslijke ziekte is, is deze wel behandelbaar. Deze behandeling omvat psycho-educatie en eventueel cognitieve rehabilitatie en / of een symptomatische farmacologische behandeling voor sommige patiënten. Voor de klinische praktijk is aldus case finding en een tijdige diagnose aangewezen. Een tijdige en correcte diagnose is zinvol, ook vanaf de eerste ziektesymptomen, mits patiënt en/of de omgeving van de patiënt een hulpvraag hebben.

Published
2017

42. Detecting frail, older adults and identifying their strengths: results of a mixed-methods study

Author

Dury, Sarah, primary, Dierckx, Eva, additional, van der Vorst, Anne, additional, Van der Elst, Michaël, additional, Fret, Bram, additional, Duppen, Daan, additional, Hoeyberghs, Lieve, additional, De Roeck, Ellen, additional, Lambotte, Deborah, additional, Smetcoren, An-Sofie, additional, Schols, Jos, additional, Kempen, Gertrudis, additional, Zijlstra, G.A. Rixt, additional, De Lepeleire, Jan, additional, Schoenmakers, Birgitte, additional, Verté, Dominique, additional, De Witte, Nico, additional, Kardol, Tinie, additional, De Deyn, Peter Paul, additional, Engelborghs, Sebastiaan, additional, and De Donder, Liesbeth, additional

Published
2018
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43. The Cerebrospinal Fluid Aβ1–42/Aβ1–40 Ratio Improves Concordance with Amyloid-PET for Diagnosing Alzheimer’s Disease in a Clinical Setting

Author

Niemantsverdriet, Ellis, primary, Ottoy, Julie, additional, Somers, Charisse, additional, De Roeck, Ellen, additional, Struyfs, Hanne, additional, Soetewey, Femke, additional, Verhaeghe, Jeroen, additional, Van den Bossche, Tobi, additional, Van Mossevelde, Sara, additional, Goeman, Johan, additional, De Deyn, Peter Paul, additional, Mariën, Peter, additional, Versijpt, Jan, additional, Sleegers, Kristel, additional, Van Broeckhoven, Christine, additional, Wyffels, Leonie, additional, Albert, Adrien, additional, Ceyssens, Sarah, additional, Stroobants, Sigrid, additional, Staelens, Steven, additional, Bjerke, Maria, additional, and Engelborghs, Sebastiaan, additional

Published
2017
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44. Concordances and differences between a unidimensional and multidimensional assessment of frailty: a cross-sectional study.

Author

Van der Elst, Michael C. J., Schoenmakers, Birgitte, Op het Veld, Linda P. M., De Roeck, Ellen E., Van der Vorst, Anne, Kempen, Gertrudis I. J. M., De Witte, Nico, De Lepeleire, Jan, Schols, Jos M. G. A., And D-SCOPE Consortium, Smetcoren, A. S., Dury, S., De Donder, L., Dierckx, E., Lambotte, D., Fret, B., Duppen, D., Kardol, M., Verté, D., and Hoeyberghs, L. J.

Subjects
FRAIL elderly, CROSS-sectional method, OLDER people, COEFFICIENT of concordance, PHYSICAL activity
Abstract

Background: Many instruments to identify frail older people have been developed. One of the consequences is that the prevalence rates of frailty vary widely dependent on the instrument selected. The aims of this study were 1) to examine the concordances and differences between a unidimensional and multidimensional assessment of frailty, 2) to assess to what extent the characteristics of a 'frail sample' differ depending on the selected frailty measurement because 'being frail' is used in many studies as an inclusion criterion.Method: A cross-sectional study was conducted among 196 community-dwelling older adults (≥60 years), which were selected from the census records. Unidimensional frailty was operationalized according to the Fried Phenotype (FP) and multidimensional frailty was measured with the Comprehensive Frailty Assessment Instrument (CFAI). The concordances and differences were examined by prevalence, correlations, observed agreement and Kappa values. Differences between sample characteristics (e.g., age, physical activity, life satisfaction) were investigated with ANOVA and Kruskall-Wallis test.Results: The mean age was 72.74 (SD 8.04) and 48.98% was male. According to the FP 23.59% was not-frail, 56.92% pre-frail and 19.49% frail. According to the CFAI, 44.33% was no-to-low frail, 37.63% was mild frail and 18.04% was high frail. The correlation between FP and the CFAI was r = 0.46 and the observed agreement was 52.85%. The Kappa value was κ = 0.35 (quadratic κ = 0.45). In total, 11.92% of the participants were frail according to both measurements, 7.77% was solely frail according to the FP and 6.21% was solely frail according to the CFAI. The 'frail sample respondents' according to the FP had higher levels of life satisfaction and net income, but performed less physical activities in comparison to high frail people according to the CFAI.Conclusion: The present study shows that the FP and CFAI partly measure the same 'frailty-construct', although differences were found for instance in the prevalence of frailty and the composition of the 'frail participants'. Since 'being frail' is an inclusion criterion in many studies, researchers must be aware that the choice of the frailty measurement has an impact on both the estimates of frailty prevalence and the characteristics of the selected sample. [ABSTRACT FROM AUTHOR]

Published
2019
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45. 18F‐FDG PET, the early phases and the delivery rate of 18F‐AV45 PET as proxies of cerebral blood flow in Alzheimer's disease: Validation against 15O‐H2O PET.

Author

Ottoy, Julie, Verhaeghe, Jeroen, Niemantsverdriet, Ellis, De Roeck, Ellen, Wyffels, Leonie, Ceyssens, Sarah, Van Broeckhoven, Christine, Engelborghs, Sebastiaan, Stroobants, Sigrid, and Staelens, Steven

Abstract

Introduction: Dual‐biomarker positron emission tomography (PET), providing complementary information on cerebral blood flow and amyloid‐β deposition, is of clinical interest for Alzheimer's disease (AD). The purpose of this study was to validate the perfusion components of early‐phase 18F‐florbetapir (eAV45), the 18F‐AV45 delivery rate (R1), and 18F‐FDG against 15O‐H2O PET and assess how they change with disease severity. Methods: This study included ten controls, 19 amnestic mild cognitive impairment, and 10 AD dementia subjects. Within‐subject regional correlations between modalities, between‐group regional and voxel‐wise analyses of covariance per modality, and receiver operating characteristic analyses for discrimination between groups were performed. Results: FDG standardized uptake value ratio, eAV45 (0–2 min) standardized uptake value ratio, and AV45‐R1 were significantly associated with H2O PET (regional Pearson r = 0.54–0.82, 0.70–0.94, and 0.65–0.92, respectively; P <.001). All modalities confirmed reduced cerebral blood flow in the posterior cingulate of patients with amnestic mild cognitive impairment and AD dementia, which was associated with lower cognition (r = 0.36–0.65, P <.025) and could discriminate between patient and control groups (area under the curve > 0.80). However, eAV45 was less sensitive to reflect the disease severity than AV45‐R1 or FDG. Discussion: R1 is preferable over eAV45 for accurate representation of brain perfusion in dual‐biomarker PET for AD. [ABSTRACT FROM AUTHOR]

Published
2019
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46. Validation of the Semiquantitative Static SUVR Method for 18F-AV45 PET by Pharmacokinetic Modeling with an Arterial Input Function

Author

Ottoy, Julie, primary, Verhaeghe, Jeroen, additional, Niemantsverdriet, Ellis, additional, Wyffels, Leonie, additional, Somers, Charisse, additional, De Roeck, Ellen, additional, Struyfs, Hanne, additional, Soetewey, Femke, additional, Deleye, Steven, additional, Van den Bossche, Tobi, additional, Van Mossevelde, Sara, additional, Ceyssens, Sarah, additional, Versijpt, Jan, additional, Stroobants, Sigrid, additional, Engelborghs, Sebastiaan, additional, and Staelens, Steven, additional

Published
2017
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47. A Decade of Cerebrospinal Fluid Biomarkers for Alzheimer’s Disease in Belgium

Author

Somers, Charisse, primary, Struyfs, Hanne, additional, Goossens, Joery, additional, Niemantsverdriet, Ellis, additional, Luyckx, Jill, additional, De Roeck, Naomi, additional, De Roeck, Ellen, additional, De Vil, Bart, additional, Cras, Patrick, additional, Martin, Jean-Jacques, additional, De Deyn, Peter-Paul, additional, Bjerke, Maria, additional, and Engelborghs, Sebastiaan, additional

Published
2016
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48. The Cerebrospinal Fluid Neurogranin/BACE1 Ratio is a Potential Correlate of Cognitive Decline in Alzheimer’s Disease

Author

De Vos, Ann, primary, Struyfs, Hanne, additional, Jacobs, Dirk, additional, Fransen, Erik, additional, Klewansky, Tom, additional, De Roeck, Ellen, additional, Robberecht, Caroline, additional, Van Broeckhoven, Christine, additional, Duyckaerts, Charles, additional, Engelborghs, Sebastiaan, additional, and Vanmechelen, Eugeen, additional

Published
2016
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49. P4-322: CSF Biomarkers to Predict Rate of Cognitive Decline in Alzheimer’S Disease

Author

Struyfs, Hanne, primary, Vanmechelen, Eugeen, additional, De Roeck, Ellen Elisa, additional, Fransen, Erik, additional, Niemantsverdriet, Ellis, additional, Somers, Charisse, additional, Goossens, Joery, additional, De Vos, Ann, additional, Herbst, Victor, additional, Van den Bossche, Tobi, additional, Van Mossevelde, Sara, additional, Goeman, Johan, additional, de Deyn, Peter Paul, additional, Bjerke, Maria, additional, and Engelborghs, Sebastiaan, additional

Published
2016
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50. P1-170: A Decade of Cerebrospinal Fluid Biomarkers for Alzheimer’s Disease in Belgium

Author

Somers, Charisse, primary, Struyfs, Hanne, additional, Goossens, Joery, additional, Niemantsverdriet, Ellis, additional, Luyckx, Jill, additional, De Roeck, Naomi, additional, De Roeck, Ellen Elisa, additional, De Vil, Bart, additional, Cras, Patrick, additional, Martin, Jean-Jacques, additional, de Deyn, Peter Paul, additional, Bjerke, Maria, additional, and Engelborghs, Sebastiaan, additional

Published
2016
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