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La enfermedad de Creutzfeldt-Jakob (ECJ) es una afección neurodege-nerativa rápidamente progresiva y mortal producida por priones. Es la más común de las encefalopatías espongiformes. La hipótesis prevalente sugiere que se inicia y propaga por conversión de una proteína priónica normal (PrP) en una isoforma conformacional anormal (PrPreS), que se acumula en el cerebro causando destrucción neuronal. Se reporta el caso de dos pacientes asistido en el Servicio de Neurología del Hospital Lagomaggiore de la ciudad de Mendoza en el período de 2 años: mujer de 49 años con cuadro de deterioro cognitivo rápidamente progresivo asociado a trastorno de la marcha y ataxia de 2 meses de evolución; y varón de 54 años con conductas inapropiadas y desorientación temporo-espacial de 20 días de evolución. Ambos con EEG compatible y proteína 14.3.3 positiva, falleciendo semanas después del diagnóstico. Se discute ambos casos, los cuales representaron un desafío diagnóstico dada la baja frecuencia y escaso reconocimiento de esta entidad en nuestro medio, debiendo debe ser considerado en pacientes que evolucionan a una demencia rápidamente progresiva. Creutzfeldt-Jakob disease (CJD) is a rapidly progressive and fatal neurodegenerative disease caused by prions. It is the most common of spongiform encephalopathies. The most accepted hypothesis suggests that it initiates and propagates through conversion of normal prion protein (PrP) in an abnormal conformational isoform (PrPres), which accumulates in the brain causing neuronal destruction. The cases of two patients assisted in the Department of Neurology of Hospital Lagomaggiore city of Mendoza in 2-year period are reported: A 49-year old female patient with symptoms of rapidly progressing cognitive impairment associated with gait disturbance and ataxia of 2 months of progression; and a 54-year old male with misconduct and temporo-spatial disorientation of 20 days of evolution. In both cases, EEG was compatible with CJD and 14.3.3 protein was positive, dying weeks after diagnosis. Both cases are discussed, which represented a diagnostic challenge given the low frequency and little recognition of this entity in our environment, must be considered in patients who develop a rapidly progressive dementia. Fil: Galiana, Graciana Lourdes. Hospital Luis Lagomaggiore (Mendoza, Argentina) Fil: Farfan Alé, F.. Hospital Luis Lagomaggiore (Mendoza, Argentina) Fil: De Monte, M.. Hospital Luis Lagomaggiore (Mendoza, Argentina) Fil: Sánchez, C.. Hospital Luis Lagomaggiore (Mendoza, Argentina) Fil: Torres, A.. Hospital Luis Lagomaggiore (Mendoza, Argentina) Fil: Ianardi, S.. Hospital Luis Lagomaggiore (Mendoza, Argentina) Fil: Genco, J.. Hospital Luis Lagomaggiore (Mendoza, Argentina) Fil: Genco, D.. Hospital Luis Lagomaggiore (Mendoza, Argentina) Fil: Castellino, G.. Hospital Luis Lagomaggiore (Mendoza, Argentina)

For several decades now, plastic components have been used more and more is the automotive industry, both for supporting and for aesthetic elements. For such uses, goals like reduction of weight and of production costs, improvement of production plant flexibility, have assumed as ever increasing importance and have been considered important for companies to define their capability on answering to market requirements and challenges. Also the reduction of environmental impacts related to production, use and disposal of the components, was considererd as an important goal during recent years. With the aim investigating sole alternative production cycles of plastic components, the paper shows the process and the results of comparison between some different ways to develop the moulding and plating processes using the Life Cycle Assessment methodology. Such approach is introductory to the following evaluation of a specific component, a car trim, which has not a complex geometry but that was considered useful so initial targets of a comparison involving a plethora of possible different solutions.

The amount of municipal waste related to food packaging systems, with respect to the whole mass of municipal waste, is ever increasing. For this reason, a selection of different packaging systems has to be made from the start of production not only to favour food conservation, but also to reduce packaging mass and increase the use of recyclables. This paper presents a comparison between impacts associated with alternative packaging systems on the supply of coffee, with the aim of showing how their values change depending on the materials and processes commonly in use. To compare impacts, Life Cycle Assessment methodology was considered. This approach, which is widespread use in many different production sectors, is defined in detail in the ISO 1404· norm.

This paper presents the preliminary work done within the FIRB_VISEL project. It opens with an overview of the literacy problems related to deafness and the way in which information technology can intervene to overcome them. A theoretical framework will be introduced to explain the dsign of the educational and interactional framework of a Deaf-centred E-Learning Enviroment (DELE), which will be introduced at the end this intervntion.

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