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1. Patient-reported outcome and cognitive measures to be used in vascular and brain tumor surgery: proposal for a minimum set

Author

Schiavolin, Silvia, Mariniello, Arianna, Broggi, Morgan, Abete-Fornara, Giorgia, Bollani, Alessandra, G, Giulio Palmas, Bottini, Gabriella, Querzola, Matteo, Scarpa, Pina, Casarotti, Alessandra, De Michele, Sara, Isella, Valeria, Mauri, Ilaria, Maietti, Alessandra, Miramonti, Valentina, Orru, Maria Immacolata, Pertichetti, Marta, Pini, Elisa, Regazzoni, Rossana, Subacchi, Sara, Ferroli, Paolo, and Leonardi, Matilde

Published
2022
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3. The Imitation Game in Children With Tourette Syndrome: A Lack of Impulse Control to Mirror Environmental Stimuli.

Author

Briguglio, Matteo, Galentino, Roberta, De Michele, Sara, Dell'Osso, Bernardo, Fogassi, Leonardo, and Porta, Mauro

Subjects
MIRROR neurons, TOURETTE syndrome, GAMES, SYNDROMES in children, STIMULUS & response (Psychology)
Abstract

The learning process in humans requires continuous contacts with environmental stimuli, especially during neurodevelopmental growth. These functions are assisted by the coding potential of mirror neurons to serve social interactions. This ability to learn imitating the observed behavior is no longer necessary during adulthood, and control mechanisms prevent automatic mirroring. However, children with Gilles de la Tourette syndrome could encounter coding errors at the level of the mirror neurons system as these cortical regions are themselves the ones affected in the syndrome. Combined with impulsivity, the resulting sign would be a manifest echopraxia that persists throughout adulthood, averting these individuals from the appraisal of a spot-on motor control. [ABSTRACT FROM AUTHOR]

Published
2022
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4. Towards a common language in neurosurgical outcome evaluation: the NEON (NEurosurgical Outcome Network) proposal

Author

FERROLI, Paolo, primary, SCHIAVOLIN, Silvia, additional, MARINIELLO, Arianna, additional, ACERBI, Francesco, additional, RESTELLI, Francesco, additional, SCHIARITI, Marco, additional, LA CORTE, Emanuele, additional, FALCO, Jacopo, additional, LEVI, Vincenzo, additional, DIMECO, Francesco, additional, ASSIETTI, Roberto, additional, BONGETTA, Daniele, additional, COLOMBO, Elena V., additional, BELLOCCHI, Silvio, additional, SANGIORGI, Simone, additional, BISTAZZONI, Simona, additional, POLOSA, Maria, additional, ORRU, Maria I., additional, SPENA, Giannantonio, additional, BERNUCCI, Claudio, additional, SICIGNANO, Angelo M., additional, FANTI, Andrea, additional, BREMBILLA, Carlo, additional, RESMINI, Bruno, additional, COSTI, Emanuele, additional, CENZATO, Marco, additional, TALAMONTI, Giuseppe, additional, BOTTINI, Gabriella, additional, SCARPA, Pina, additional, BOLLANI, Alessandra, additional, QUERZOLA, Matteo, additional, PALMAS, Giulio, additional, DE GONDA, Federico, additional, BOSIO, Lorenzo, additional, EGIDI, Marcello, additional, TARDIVO, Valentina, additional, FIORAVANTI, Antonio, additional, SUBACCHI, Sara, additional, FONTANELLA, Marco, additional, BIROLI, Antonio, additional, CEREDA, Claudio, additional, PANCIANI, Pier Paolo, additional, BERGOMI, Riccardo, additional, PERTICHETTI, Marta, additional, TANCIONI, Flavio, additional, BONA, Alberto, additional, TARTARA, Fulvio A., additional, FORNARI, Maurizio, additional, PESSINA, Federico, additional, LASIO, Giovanni, additional, CARDIA, Andrea, additional, SERVADEI, Franco, additional, RIVA, Marco, additional, CASAROTTI, Alessandra, additional, GIUSSANI, Carlo, additional, FIORI, Leonardo, additional, MAZZOLENI, Fabio, additional, VAIANI, Simona, additional, CARRABBA, Giorgio, additional, DI CRISTOFORI, Andrea, additional, SGANZERLA, Erik P., additional, VIMERCATI, Alberto, additional, ISELLA, Valeria, additional, MAURI, Ilaria, additional, INCERTI, Michele, additional, SICURI, Giovanni, additional, MIRAMONTI, Valentina, additional, STEFINI, Roberto, additional, SPAGNOLI, Diego, additional, PIPARO, Maurizio, additional, GRIMOD, Gianluca, additional, REGAZZONI, Rossana, additional, VISMARA, Daniela, additional, MAZZEO, Lucio, additional, MONTI, Emanuele, additional, FRANZIN, Alberto, additional, VIVALDI, Oscar, additional, MAIETTI, Alessandra, additional, PINI, Elisa, additional, SERVELLO, Domenico, additional, ZEKAJ, Edvin, additional, DE MICHELE, Sara, additional, LOCATELLI, Marco, additional, BORSA, Stefano, additional, GRIMOLDI, Nadia, additional, CAROLI, Manuela, additional, TARICIOTTI, Leonardo, additional, ABETE-FORNARA, Giorgia, additional, VITALE, Mario, additional, LEONARDI, Matilde, additional, and BROGGI, Morgan, additional

Published
2023
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5. Towards a common language in neurosurgical outcome evaluation: the NEON (NEurosurgical Outcome Network) proposal

Author

Ferroli, Paolo, Schiavolin, Silvia, Mariniello, Arianna, Acerbi, Francesco, Restelli, Francesco, Schiariti, Marco, LA Corte, Emanuele, Falco, Jacopo, Levi, Vincenzo, Dimeco, Francesco, Assietti, Roberto, Bongetta, Daniele, V Colombo, Elena, Bellocchi, Silvio, Sangiorgi, Simone, Bistazzoni, Simona, Polosa, Maria, I Orru, Maria, Spena, Giannantonio, Bernucci, Claudio, M Sicignano, Angelo, Fanti, Andrea, Brembilla, Carlo, Resmini, Bruno, Costi, Emanuele, Cenzato, Marco, Talamonti, Giuseppe, Bottini, Gabriella, Scarpa, Pina, Bollani, Alessandra, Querzola, Matteo, Palmas, Giulio, DE Gonda, Federico, Bosio, Lorenzo, Egidi, Marcello, Tardivo, Valentina, Fioravanti, Antonio, Subacchi, Sara, Fontanella, Marco, Biroli, Antonio, Cereda, Claudio, Paolo Panciani, Pier, Bergomi, Riccardo, Pertichetti, Marta, Tancioni, Flavio, Bona, Alberto, A Tartara, Fulvio, Fornari, Maurizio, Pessina, Federico, Lasio, Giovanni, Cardia, Andrea, Servadei, Franco, Riva, Marco, Casarotti, Alessandra, Giussani, Carlo, Fiori, Leonardo, Mazzoleni, Fabio, Vaiani, Simona, Carrabba, Giorgio, DI Cristofori, Andrea, P Sganzerla, Erik, Vimercati, Alberto, Isella, Valeria, Mauri, Ilaria, Incerti, Michele, Sicuri, Giovanni, Miramonti, Valentina, Stefini, Roberto, Spagnoli, Diego, Piparo, Maurizio, Grimod, Gianluca, Regazzoni, Rossana, Vismara, Daniela, Mazzeo, Lucio, Monti, Emanuele, Franzin, Alberto, Vivaldi, Oscar, Maietti, Alessandra, Pini, Elisa, Servello, Domenico, Zekaj, Edvin, DE Michele, Sara, Locatelli, Marco, Borsa, Stefano, Grimoldi, Nadia, Caroli, Manuela, Tariciotti, Leonardo, Abete-Fornara, Giorgia, Vitale, Mario, Leonardi, Matilde, Broggi, Morgan, Paolo Ferroli, Silvia Schiavolin, Arianna Mariniello, Francesco Acerbi, Francesco Restelli, Marco Schiariti, Emanuele LA Corte, Jacopo Falco, Vincenzo Levi, Francesco Dimeco, Roberto Assietti, Daniele Bongetta, Elena V Colombo, Silvio Bellocchi, Simone Sangiorgi, Simona Bistazzoni, Maria Polosa, Maria I Orru, Giannantonio Spena, Claudio Bernucci, Angelo M Sicignano, Andrea Fanti, Carlo Brembilla, Bruno Resmini, Emanuele Costi, Marco Cenzato, Giuseppe Talamonti, Gabriella Bottini, Pina Scarpa, Alessandra Bollani, Matteo Querzola, Giulio Palmas, Federico DE Gonda, Lorenzo Bosio, Marcello Egidi, Valentina Tardivo, Antonio Fioravanti, Sara Subacchi, Marco Fontanella, Antonio Biroli, Claudio Cereda, Pier Paolo Panciani, Riccardo Bergomi, Marta Pertichetti, Flavio Tancioni, Alberto Bona, Fulvio A Tartara, Maurizio Fornari, Federico Pessina, Giovanni Lasio, Andrea Cardia, Franco Servadei, Marco Riva, Alessandra Casarotti, Carlo Giussani, Leonardo Fiori, Fabio Mazzoleni, Simona Vaiani, Giorgio Carrabba, Andrea DI Cristofori, Erik P Sganzerla, Alberto Vimercati, Valeria Isella, Ilaria Mauri, Michele Incerti, Giovanni Sicuri, Valentina Miramonti, Roberto Stefini, Diego Spagnoli, Maurizio Piparo, Gianluca Grimod, Rossana Regazzoni, Daniela Vismara, Lucio Mazzeo, Emanuele Monti, Alberto Franzin, Oscar Vivaldi, Alessandra Maietti (ORCID:0000-0002-9819-7037), Elisa Pini, Domenico Servello, Edvin Zekaj, Sara DE Michele, Marco Locatelli, Stefano Borsa, Nadia Grimoldi, Manuela Caroli, Leonardo Tariciotti, Giorgia Abete-Fornara, Mario Vitale, Matilde Leonardi, Morgan Broggi, Ferroli, Paolo, Schiavolin, Silvia, Mariniello, Arianna, Acerbi, Francesco, Restelli, Francesco, Schiariti, Marco, LA Corte, Emanuele, Falco, Jacopo, Levi, Vincenzo, Dimeco, Francesco, Assietti, Roberto, Bongetta, Daniele, V Colombo, Elena, Bellocchi, Silvio, Sangiorgi, Simone, Bistazzoni, Simona, Polosa, Maria, I Orru, Maria, Spena, Giannantonio, Bernucci, Claudio, M Sicignano, Angelo, Fanti, Andrea, Brembilla, Carlo, Resmini, Bruno, Costi, Emanuele, Cenzato, Marco, Talamonti, Giuseppe, Bottini, Gabriella, Scarpa, Pina, Bollani, Alessandra, Querzola, Matteo, Palmas, Giulio, DE Gonda, Federico, Bosio, Lorenzo, Egidi, Marcello, Tardivo, Valentina, Fioravanti, Antonio, Subacchi, Sara, Fontanella, Marco, Biroli, Antonio, Cereda, Claudio, Paolo Panciani, Pier, Bergomi, Riccardo, Pertichetti, Marta, Tancioni, Flavio, Bona, Alberto, A Tartara, Fulvio, Fornari, Maurizio, Pessina, Federico, Lasio, Giovanni, Cardia, Andrea, Servadei, Franco, Riva, Marco, Casarotti, Alessandra, Giussani, Carlo, Fiori, Leonardo, Mazzoleni, Fabio, Vaiani, Simona, Carrabba, Giorgio, DI Cristofori, Andrea, P Sganzerla, Erik, Vimercati, Alberto, Isella, Valeria, Mauri, Ilaria, Incerti, Michele, Sicuri, Giovanni, Miramonti, Valentina, Stefini, Roberto, Spagnoli, Diego, Piparo, Maurizio, Grimod, Gianluca, Regazzoni, Rossana, Vismara, Daniela, Mazzeo, Lucio, Monti, Emanuele, Franzin, Alberto, Vivaldi, Oscar, Maietti, Alessandra, Pini, Elisa, Servello, Domenico, Zekaj, Edvin, DE Michele, Sara, Locatelli, Marco, Borsa, Stefano, Grimoldi, Nadia, Caroli, Manuela, Tariciotti, Leonardo, Abete-Fornara, Giorgia, Vitale, Mario, Leonardi, Matilde, Broggi, Morgan, Paolo Ferroli, Silvia Schiavolin, Arianna Mariniello, Francesco Acerbi, Francesco Restelli, Marco Schiariti, Emanuele LA Corte, Jacopo Falco, Vincenzo Levi, Francesco Dimeco, Roberto Assietti, Daniele Bongetta, Elena V Colombo, Silvio Bellocchi, Simone Sangiorgi, Simona Bistazzoni, Maria Polosa, Maria I Orru, Giannantonio Spena, Claudio Bernucci, Angelo M Sicignano, Andrea Fanti, Carlo Brembilla, Bruno Resmini, Emanuele Costi, Marco Cenzato, Giuseppe Talamonti, Gabriella Bottini, Pina Scarpa, Alessandra Bollani, Matteo Querzola, Giulio Palmas, Federico DE Gonda, Lorenzo Bosio, Marcello Egidi, Valentina Tardivo, Antonio Fioravanti, Sara Subacchi, Marco Fontanella, Antonio Biroli, Claudio Cereda, Pier Paolo Panciani, Riccardo Bergomi, Marta Pertichetti, Flavio Tancioni, Alberto Bona, Fulvio A Tartara, Maurizio Fornari, Federico Pessina, Giovanni Lasio, Andrea Cardia, Franco Servadei, Marco Riva, Alessandra Casarotti, Carlo Giussani, Leonardo Fiori, Fabio Mazzoleni, Simona Vaiani, Giorgio Carrabba, Andrea DI Cristofori, Erik P Sganzerla, Alberto Vimercati, Valeria Isella, Ilaria Mauri, Michele Incerti, Giovanni Sicuri, Valentina Miramonti, Roberto Stefini, Diego Spagnoli, Maurizio Piparo, Gianluca Grimod, Rossana Regazzoni, Daniela Vismara, Lucio Mazzeo, Emanuele Monti, Alberto Franzin, Oscar Vivaldi, Alessandra Maietti (ORCID:0000-0002-9819-7037), Elisa Pini, Domenico Servello, Edvin Zekaj, Sara DE Michele, Marco Locatelli, Stefano Borsa, Nadia Grimoldi, Manuela Caroli, Leonardo Tariciotti, Giorgia Abete-Fornara, Mario Vitale, Matilde Leonardi, and Morgan Broggi

Abstract

BACKGROUNDː To achieve a consensus on the minimum set of outcome measures and predictors to be used in the neurosurgical practice and on the timing of outcome assessment. METHODSː A consensus building approach was employed. All neurosurgical departments in Lombardy (Italy) were invited to participate by the Fondazione IRCCS Istituto Neurologico Carlo Besta. Three workshops were organized during which a multidisciplinary group called Neurosurgical Outcome Network (NEON) was created and the methodology to select outcome measures, predictors, and timing of outcome assessment was established. Eight working groups were created for the different neurosurgical diseases (neuro-oncological, skull base, vascular, traumatic, spinal, peripheral nervous system, malformation, functional) and 8 workshops were organized to identify the outcome measures and predictors specific for each of the neurosurgical diseases based on the experts’ clinical practice and the existing literature. RESULTSː A total of 20 neurosurgical departments participated in this study. Specific outcome measures, predictors and the timing of outcome assessment were identified for each of the 8 neurosurgical diseases. Moreover, a list of variables common to all pathologies were identified by the NEON group as further data to be collected. CONCLUSIONSː A consensus on the minimum set of outcome measures and predictors and the timing of outcome assessments for 8 neurosurgical diseases was achieved by a group of neurosurgeons of the Lombardy region, called NEON. These sets could be used in future studies for a more homogeneous data collection and as a starting point to reach further agreement also at national and international level.

Published
2023

6. Towards a common language in neurosurgical outcome evaluation: the NEON (NEurosurgical Outcome Network) proposal

Author

Ferroli, P, Schiavolin, S, Mariniello, A, Acerbi, F, Restelli, F, Schiariti, M, LA Corte, E, Falco, J, Levi, V, Dimeco, F, Assietti, R, Bongetta, D, Colombo, E, Bellocchi, S, Sangiorgi, S, Bistazzoni, S, Polosa, M, Orru, M, Spena, G, Bernucci, C, Sicignano, A, Fanti, A, Brembilla, C, Resmini, B, Costi, E, Cenzato, M, Talamonti, G, Bottini, G, Scarpa, P, Bollani, A, Querzola, M, Palmas, G, DE Gonda, F, Bosio, L, Egidi, M, Tardivo, V, Fioravanti, A, Subacchi, S, Fontanella, M, Biroli, A, Cereda, C, Panciani, P, Bergomi, R, Pertichetti, M, Tancioni, F, Bona, A, Tartara, F, Fornari, M, Pessina, F, Lasio, G, Cardia, A, Servadei, F, Riva, M, Casarotti, A, Giussani, C, Fiori, L, Mazzoleni, F, Vaiani, S, Carrabba, G, DI Cristofori, A, Sganzerla, E, Vimercati, A, Isella, V, Mauri, I, Incerti, M, Sicuri, G, Miramonti, V, Stefini, R, Spagnoli, D, Piparo, M, Grimod, G, Regazzoni, R, Vismara, D, Mazzeo, L, Monti, E, Franzin, A, Vivaldi, O, Maietti, A, Pini, E, Servello, D, Zekaj, E, DE Michele, S, Locatelli, M, Borsa, S, Grimoldi, N, Caroli, M, Tariciotti, L, Abete-Fornara, G, Vitale, M, Leonardi, M, Broggi, M, Ferroli, Paolo, Schiavolin, Silvia, Mariniello, Arianna, Acerbi, Francesco, Restelli, Francesco, Schiariti, Marco, LA Corte, Emanuele, Falco, Jacopo, Levi, Vincenzo, Dimeco, Francesco, Assietti, Roberto, Bongetta, Daniele, Colombo, Elena V, Bellocchi, Silvio, Sangiorgi, Simone, Bistazzoni, Simona, Polosa, Maria, Orru, Maria I, Spena, Giannantonio, Bernucci, Claudio, Sicignano, Angelo M, Fanti, Andrea, Brembilla, Carlo, Resmini, Bruno, Costi, Emanuele, Cenzato, Marco, Talamonti, Giuseppe, Bottini, Gabriella, Scarpa, Pina, Bollani, Alessandra, Querzola, Matteo, Palmas, Giulio, DE Gonda, Federico, Bosio, Lorenzo, Egidi, Marcello, Tardivo, Valentina, Fioravanti, Antonio, Subacchi, Sara, Fontanella, Marco, Biroli, Antonio, Cereda, Claudio, Panciani, Pier Paolo, Bergomi, Riccardo, Pertichetti, Marta, Tancioni, Flavio, Bona, Alberto, Tartara, Fulvio A, Fornari, Maurizio, Pessina, Federico, Lasio, Giovanni, Cardia, Andrea, Servadei, Franco, Riva, Marco, Casarotti, Alessandra, Giussani, Carlo, Fiori, Leonardo, Mazzoleni, Fabio, Vaiani, Simona, Carrabba, Giorgio, DI Cristofori, Andrea, Sganzerla, Erik P, Vimercati, Alberto, Isella, Valeria, Mauri, Ilaria, Incerti, Michele, Sicuri, Giovanni, Miramonti, Valentina, Stefini, Roberto, Spagnoli, Diego, Piparo, Maurizio, Grimod, Gianluca, Regazzoni, Rossana, Vismara, Daniela, Mazzeo, Lucio, Monti, Emanuele, Franzin, Alberto, Vivaldi, Oscar, Maietti, Alessandra, Pini, Elisa, Servello, Domenico, Zekaj, Edvin, DE Michele, Sara, Locatelli, Marco, Borsa, Stefano, Grimoldi, Nadia, Caroli, Manuela, Tariciotti, Leonardo, Abete-Fornara, Giorgia, Vitale, Mario, Leonardi, Matilde, Broggi, Morgan, Ferroli, P, Schiavolin, S, Mariniello, A, Acerbi, F, Restelli, F, Schiariti, M, LA Corte, E, Falco, J, Levi, V, Dimeco, F, Assietti, R, Bongetta, D, Colombo, E, Bellocchi, S, Sangiorgi, S, Bistazzoni, S, Polosa, M, Orru, M, Spena, G, Bernucci, C, Sicignano, A, Fanti, A, Brembilla, C, Resmini, B, Costi, E, Cenzato, M, Talamonti, G, Bottini, G, Scarpa, P, Bollani, A, Querzola, M, Palmas, G, DE Gonda, F, Bosio, L, Egidi, M, Tardivo, V, Fioravanti, A, Subacchi, S, Fontanella, M, Biroli, A, Cereda, C, Panciani, P, Bergomi, R, Pertichetti, M, Tancioni, F, Bona, A, Tartara, F, Fornari, M, Pessina, F, Lasio, G, Cardia, A, Servadei, F, Riva, M, Casarotti, A, Giussani, C, Fiori, L, Mazzoleni, F, Vaiani, S, Carrabba, G, DI Cristofori, A, Sganzerla, E, Vimercati, A, Isella, V, Mauri, I, Incerti, M, Sicuri, G, Miramonti, V, Stefini, R, Spagnoli, D, Piparo, M, Grimod, G, Regazzoni, R, Vismara, D, Mazzeo, L, Monti, E, Franzin, A, Vivaldi, O, Maietti, A, Pini, E, Servello, D, Zekaj, E, DE Michele, S, Locatelli, M, Borsa, S, Grimoldi, N, Caroli, M, Tariciotti, L, Abete-Fornara, G, Vitale, M, Leonardi, M, Broggi, M, Ferroli, Paolo, Schiavolin, Silvia, Mariniello, Arianna, Acerbi, Francesco, Restelli, Francesco, Schiariti, Marco, LA Corte, Emanuele, Falco, Jacopo, Levi, Vincenzo, Dimeco, Francesco, Assietti, Roberto, Bongetta, Daniele, Colombo, Elena V, Bellocchi, Silvio, Sangiorgi, Simone, Bistazzoni, Simona, Polosa, Maria, Orru, Maria I, Spena, Giannantonio, Bernucci, Claudio, Sicignano, Angelo M, Fanti, Andrea, Brembilla, Carlo, Resmini, Bruno, Costi, Emanuele, Cenzato, Marco, Talamonti, Giuseppe, Bottini, Gabriella, Scarpa, Pina, Bollani, Alessandra, Querzola, Matteo, Palmas, Giulio, DE Gonda, Federico, Bosio, Lorenzo, Egidi, Marcello, Tardivo, Valentina, Fioravanti, Antonio, Subacchi, Sara, Fontanella, Marco, Biroli, Antonio, Cereda, Claudio, Panciani, Pier Paolo, Bergomi, Riccardo, Pertichetti, Marta, Tancioni, Flavio, Bona, Alberto, Tartara, Fulvio A, Fornari, Maurizio, Pessina, Federico, Lasio, Giovanni, Cardia, Andrea, Servadei, Franco, Riva, Marco, Casarotti, Alessandra, Giussani, Carlo, Fiori, Leonardo, Mazzoleni, Fabio, Vaiani, Simona, Carrabba, Giorgio, DI Cristofori, Andrea, Sganzerla, Erik P, Vimercati, Alberto, Isella, Valeria, Mauri, Ilaria, Incerti, Michele, Sicuri, Giovanni, Miramonti, Valentina, Stefini, Roberto, Spagnoli, Diego, Piparo, Maurizio, Grimod, Gianluca, Regazzoni, Rossana, Vismara, Daniela, Mazzeo, Lucio, Monti, Emanuele, Franzin, Alberto, Vivaldi, Oscar, Maietti, Alessandra, Pini, Elisa, Servello, Domenico, Zekaj, Edvin, DE Michele, Sara, Locatelli, Marco, Borsa, Stefano, Grimoldi, Nadia, Caroli, Manuela, Tariciotti, Leonardo, Abete-Fornara, Giorgia, Vitale, Mario, Leonardi, Matilde, and Broggi, Morgan

Abstract

Background: The aim of this study was to achieve a consensus on the minimum set of outcome measures and predictors to be used in the neurosurgical practice and on the timing of outcome assessment. Methods: A consensus building approach was employed. All neurosurgical departments in Lombardy (Italy) were invited to participate by the Carlo Besta Neurologic Institute IRCCS Foundation. Three workshops were organized during which a multidisciplinary group called Neurosurgical Outcome Network (NEON) was created and the methodology to select outcome measures, predictors, and timing of outcome assessment was established. Eight working groups were created for the different neurosurgical diseases (neuro-oncological, skull base, vascular, traumatic, spinal, peripheral nervous system, malformation, functional) and 8 workshops were organized to identify the outcome measures and predictors specific for each of the neurosurgical diseases based on the experts' clinical practice and the existing literature. Results: A total of 20 neurosurgical departments participated in this study. Specific outcome measures, predictors and the timing of outcome assessment were identified for each of the 8 neurosurgical diseases. Moreover, a list of variables common to all pathologies were identified by the NEON group as further data to be collected. Conclusions: A consensus on the minimum set of outcome measures and predictors and the timing of outcome assessments for 8 neurosurgical diseases was achieved by a group of neurosurgeons of the Lombardy region, called NEON. These sets could be used in future studies for a more homogeneous data collection and as a starting point to reach further agreement also at national and international level.

Published
2023

7. Assessing response, remission, and treatment resistance in patients with obsessive–compulsive disorder with and without tic disorders: results from a multicenter study

Author

Benatti, Beatrice, primary, Girone, Nicolaja, additional, Conti, Dario, additional, Cafaro, Rita, additional, Viganò, Caterina, additional, Briguglio, Matteo, additional, Marazziti, Donatella, additional, Mucci, Federico, additional, Gambini, Orsola, additional, Demartini, Benedetta, additional, Tundo, Antonio, additional, Necci, Roberta, additional, De Berardis, Domenico, additional, Galentino, Roberta, additional, De Michele, Sara, additional, Balestrino, Roberta, additional, Albert, Umberto, additional, Rigardetto, Sylvia, additional, Maina, Giuseppe, additional, Grassi, Giacomo, additional, Pallanti, Stefano, additional, Amerio, Andrea, additional, Aguglia, Andrea, additional, Prestia, Davide, additional, Amore, Mario, additional, Priori, Alberto, additional, Servello, Domenico, additional, Porta, Mauro, additional, and Dell’Osso, Bernardo, additional

Published
2021
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8. Assessing response, remission, and treatment resistance in patients with obsessive–compulsive disorder with and without tic disorders: results from a multicenter study

Author

Benatti, Beatrice, Girone, Nicolaja, Conti, Dario, Cafaro, Rita, Viganò, Caterina, Briguglio, Matteo, Marazziti, Donatella, Mucci, Federico, Gambini, Orsola, Demartini, Benedetta, Tundo, Antonio, Necci, Roberta, De Berardis, Domenico, Galentino, Roberta, De Michele, Sara, Balestrino, Roberta, Albert, Umberto, Rigardetto, Sylvia, Maina, Giuseppe, Grassi, Giacomo, Pallanti, Stefano, Amerio, Andrea, Aguglia, Andrea, Prestia, Davide, Amore, Mario, Priori, Alberto, Servello, Domenico, Porta, Mauro, and Dell’Osso, Bernardo

Abstract

AbstractBackgroundHighlighting the relationship between obsessive–compulsive disorder (OCD) and tic disorder (TD), two highly disabling, comorbid, and difficult-to-treat conditions, Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5) acknowledged a new “tic-related” specifier for OCD, ie, obsessive–compulsive tic-related disorder (OCTD). As patients with OCTD may frequently show poor treatment response, the aim of this multicenter study was to investigate rates and clinical correlates of response, remission, and treatment resistance in a large multicenter sample of OCD patients with versus without tics.MethodsA sample of 398 patients with a DSM-5 diagnosis of OCD with and without comorbid TD was assessed from 10 different psychiatric departments across Italy. For the purpose of the study, treatment response profiles in the whole sample were analyzed comparing the rates of response, remission, and treatment-resistance as well as related clinical features. Multivariate logistic regressions were performed to identify possible factors associated with treatment response.ResultsThe remission group was associated with later ages of onset of TD and OCD. Moreover, significantly higher rates of psychiatric comorbidities, TD, and lifetime suicidal ideation and attempts emerged in the treatment-resistant group, with larger degrees of perceived worsened quality of life and family involvement.ConclusionsAlthough remission was associated with later ages of OCD and TD onset, specific clinical factors, such as early onset and presence of psychiatric comorbidities and concomitant TD, predicted a worse treatment response with a significant impairment in quality of life for both patients and their caregivers, suggesting a worse profile of treatment response for patients with OCTD.

Published
2022
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10. Suicidal ideation and suicidal attempts in patients with obsessive-compulsive tic-related disorder vs obsessive-compulsive disorder: results of a multicenter Italian study

Author

Benatti, Beatrice, primary, Ferrari, Silvia, additional, Grancini, Benedetta, additional, Girone, Nicolaja, additional, Briguglio, Matteo, additional, Marazziti, Donatella, additional, Mucci, Federico, additional, Dell’Osso, Liliana, additional, Gambini, Orsola, additional, Demartini, Benedetta, additional, Tundo, Antonio, additional, Necci, Roberta, additional, De Berardis, Domenico, additional, Galentino, Roberta, additional, De Michele, Sara, additional, Albert, Umberto, additional, Rigardetto, Sylvia, additional, Maina, Giuseppe, additional, Grassi, Giacomo, additional, Pallanti, Stefano, additional, Amerio, Andrea, additional, Amore, Mario, additional, Priori, Alberto, additional, Servello, Domenico, additional, Viganò, Caterina, additional, Bosi, Monica, additional, Colombo, Anna, additional, Porta, Mauro, additional, and Dell’Osso, Bernardo, additional

Published
2020
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12. Suicidal ideation and suicidal attempts in patients with obsessive-compulsive tic-related disorder vs obsessive-compulsive disorder: results of a multicenter Italian study

Author

Benatti, Beatrice, Ferrari, Silvia, Grancini, Benedetta, Girone, Nicolaja, Briguglio, Matteo, Marazziti, Donatella, Mucci, Federico, Dell’Osso, Liliana, Gambini, Orsola, Demartini, Benedetta, Tundo, Antonio, Necci, Roberta, De Berardis, Domenico, Galentino, Roberta, De Michele, Sara, Albert, Umberto, Rigardetto, Sylvia, Maina, Giuseppe, Grassi, Giacomo, Pallanti, Stefano, Amerio, Andrea, Amore, Mario, Priori, Alberto, Servello, Domenico, Viganò, Caterina, Bosi, Monica, Colombo, Anna, Porta, Mauro, and Dell’Osso, Bernardo

Abstract

AbstractBackgroundObsessive-compulsive disorder (OCD) and tic disorder (TD) represent highly disabling, chronic and often comorbid psychiatric conditions. While recent studies showed a high risk of suicide for patients with OCD, little is known about those patients with comorbid TD (OCTD). Aim of this study was to characterize suicidal behaviors among patients with OCD and OCTD.MethodsThree hundred and thirteen outpatients with OCD (n = 157) and OCTD (n = 156) were recruited from nine different psychiatric Italian departments and assessed using an ad-hoc developed questionnaire investigating, among other domains, suicide attempt (SA) and ideation (SI). The sample was divided into four subgroups: OCD with SA (OCD-SA), OCD without SA (OCD-noSA), OCTD with SA (OCTD-SA), and OCTD without SA (OCTD-noSA).ResultsNo differences between groups were found in terms of SI, while SA rates were significantly higher in patients with OCTD compared to patients with OCD. OCTD-SA group showed a significant male prevalence and higher unemployment rates compared to OCD-SA and OCD-noSA sample. Both OCTD-groups showed an earlier age of psychiatric comorbidity onset (other than TD) compared to the OCD-SA sample. Moreover, patients with OCTD-SA showed higher rates of other psychiatric comorbidities and positive psychiatric family history compared to the OCD-SA group and to the OCD-noSA groups. OCTD-SA and OCD-SA samples showed higher rates of antipsychotics therapies and treatment resistance compared to OCD-noSA groups.ConclusionsPatients with OCTD vs with OCD showed a significantly higher rate of SA with no differences in SI. In particular, OCTD-SA group showed different unfavorable epidemiological and clinical features which need to be confirmed in future prospective studies.

Published
2021
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13. Food bioactive compounds and their interference in drug pharmacokinetic/pharmacodynamic profiles

Author

Silvana Hrelia, De Michele S, Bernardo Dell'Osso, Roberta Galentino, Roberto Canaparo, Mauro Porta, Matteo Briguglio, Marco Malaguti, Carlotta Zanaboni Dina, Loredana Serpe, Giuseppe Banfi, Briguglio, Matteo, Hrelia, Silvana, Malaguti, Marco, Serpe, Loredana, Canaparo, Roberto, Dell’Osso, Bernardo, Galentino, Roberta, De Michele, Sara, Dina, Carlotta Zanaboni, Porta, Mauro, Banfi, Giuseppe, and Briguglio M, Hrelia S, Malaguti M, Serpe L, Canaparo R, Dell'Osso B, Galentino R, De Michele S, Dina CZ, Porta M, Banfi G

Subjects
0301 basic medicine, Drug, Pharmacologic processe, media_common.quotation_subject, precision medicine, Pharmaceutical Science, lcsh:RS1-441, food-drug interactions, Review, pharmacologic processes, Bioinformatics, Efficacy, lcsh:Pharmacy and materia medica, dietary supplements, 03 medical and health sciences, Dietary supplement, Nutraceutical, herb-drug interaction, Pharmacokinetics, Herb-drug interaction, Dietary supplements, Food-drug interactions, Herb-drug interactions, Pharmacologic processes, Precision medicine, Medicine, food-drug interaction, Food-drug interaction, media_common, herb-drug interactions, 030109 nutrition & dietetics, business.industry, pharmacologic processe, Bioavailability, dietary supplement, FooDB, nutraceutical, business, DrugBank
Abstract

Preclinical and clinical studies suggest that many food molecules could interact with drug transporters and metabolizing enzymes through different mechanisms, which are predictive of what would be observed clinically. Given the recent incorporation of dietary modifications or supplements in traditional medicine, an increase in potential food-drug interactions has also appeared. The objective of this article is to review data regarding the influence of food on drug efficacy. Data from Google Scholar, PubMed, and Scopus databases was reviewed for publications on pharmaceutical, pharmacokinetic, and pharmacodynamic mechanisms. The following online resources were used to integrate functional and bioinformatic results: FooDB, Phenol-Explorer, Dr. Duke's Phytochemical and Ethnobotanical Databases, DrugBank, UniProt, and IUPHAR/BPS Guide to Pharmacology. A wide range of food compounds were shown to interact with proteins involved in drug pharmacokinetic/pharmacodynamic profiles, starting from drug oral bioavailability to enteric/hepatic transport and metabolism, blood transport, and systemic transport/metabolism. Knowledge of any food components that may interfere with drug efficacy is essential, and would provide a link for obtaining a holistic view for cancer, cardiovascular, musculoskeletal, or neurological therapies. However, preclinical interaction may be irrelevant to clinical interaction, and health professionals should be aware of the limitations if they intend to optimize the therapeutic effects of drugs.

Published
2018

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