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2. Therapy of Canine Hyperlipidemia with Bezafibrate

Author

De Marco, V, Noronha, KSM, Casado, TC, Nakandakare, ER, Florio, JC, Santos, EZ, and Gilor, C

Subjects
Veterinary Sciences, Agricultural, Veterinary and Food Sciences, Administration, Oral, Animals, Bezafibrate, Dog Diseases, Dogs, Female, Hyperlipidemias, Hypolipidemic Agents, Male, Prospective Studies, Treatment Outcome, Cholesterol, Hyperadrenocorticism, Peroxisome proliferator-activated receptor, Schnauzer, Triglyceride, Veterinary sciences
Abstract

BackgroundBezafibrate (BZF) is effective in the treatment of hypertriglyceridemia in human patients, but there are no data on its use in dogs.ObjectiveTo assess the safety of BZF in hyperlipidemic dogs and its efficacy in decreasing serum triglyceride (TG) and cholesterol (CHO) concentrations.AnimalsForty-six dogs, 26 females and 20 males, mean (±SD) age of 9 (±3) years, with TG ≥150 mg/dL (33 dogs also were hypercholesterolemic [>300 mg/dL]).MethodsProspective, uncontrolled clinical trial. Dogs were treated with bezafibrate once daily, using 200 mg tablets at a dosage of 4-10 mg/kg (depending on body weight). Serum TG and CHO concentrations and alanine aminotransferase (ALT) and creatine kinase (CK) activity before and after 30 days of treatment were compared.ResultsSixteen dogs (34.8%) had primary hyperlipidemia, and 30 dogs (65.2%) had secondary hyperlipidemia (including spontaneous hyperadrenocorticism [41.3%, n = 19/46], chronic treatment with glucocorticoids [10.8%, n = 5/46], and hypothyroidism [15.2%, n = 7/46]). After 30 days, serum TG concentration normalized (

Published
2017

10. The American Society of Anesthesiologists’ (ASA) physical status system classification predicted the risk of postoperative complications at hospital discharge in 1329 consecutive patients treated with radical prostatectomy for clinical prostate cancer

Author

Rizzetto, R., primary, Porcaro, A.B., additional, Amigoni, N., additional, Tafuri, A., additional, Cerrato, C., additional, Bianchi, A., additional, Gallina, S., additional, Orlando, R., additional, Gozzo, A., additional, Migliorini, F., additional, Antoniolli, S. Zecchini, additional, Monaco, C., additional, De Marco, V., additional, Brunelli, M., additional, Cerruto, M.A., additional, Polati, E., additional, and Antonelli, A., additional

Published
2021
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12. Upstaging after radical prostatectomy in clinically localized intermediate and high-risk prostate cancer: The role of obesity

Author

Rizzetto, R., primary, Tafuri, A., additional, Amigoni, N., additional, Sebben, M., additional, Shakir, A., additional, Gozzo, A., additional, Odorizzi, K., additional, Gallina, S., additional, Bianchi, A., additional, Ornaghi, P., additional, Brunelli, M., additional, De Marco, V., additional, Migliorini, F., additional, Cerruto, M.A., additional, Siracusano, S., additional, Artibani, W., additional, Porcaro, A.B., additional, and Antonelli, A., additional

Published
2020
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13. The impact of extended pelvic lymph node dissection on the risk of hospital readmission on the long term after robot-assisted radical prostatectomy

Author

Sebben, M., primary, Tafuri, A., additional, Shakir, A., additional, Pirozzi, M., additional, Processali, T., additional, Rizzetto, R., additional, Amigoni, N., additional, Tiso, L., additional, De Michele, M., additional, Panunzio, A., additional, Cerrato, C., additional, Migliorini, F., additional, Novella, G., additional, De Marco, V., additional, Siracusano, S., additional, Artibani, W., additional, Porcaro, A.B., additional, and Antonelli, A., additional

Published
2020
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14. Quality of life following urinary diversion: Orthotopic ileal neobladder versus ileal conduit. A multicentre study among long-term, female bladder cancer survivors

Author

Siracusano, S., D'Elia, C., Cerruto, M. A., Gacci, M., Ciciliato, S., Simonato, A., Porcaro, A., De Marco, V., Talamini, R., Toffoli, L., Saleh, O., Serni, S., Visalli, F., Niero, M., Lonardi, C., Imbimbo, C., Verze, P., Mirone, V., Racioppi, M., Iafrate, M., Cacciamani, G., De Marchi, D., Bassi, P., Artibani, W., Racioppi M. (ORCID:0000-0001-9129-8479), Bassi P. (ORCID:0000-0002-4313-8427), Siracusano, S., D'Elia, C., Cerruto, M. A., Gacci, M., Ciciliato, S., Simonato, A., Porcaro, A., De Marco, V., Talamini, R., Toffoli, L., Saleh, O., Serni, S., Visalli, F., Niero, M., Lonardi, C., Imbimbo, C., Verze, P., Mirone, V., Racioppi, M., Iafrate, M., Cacciamani, G., De Marchi, D., Bassi, P., Artibani, W., Racioppi M. (ORCID:0000-0001-9129-8479), and Bassi P. (ORCID:0000-0002-4313-8427)

Abstract

Introduction: Women undergoing radical cystectomy (RC) followed by urinary diversion (UD) for bladder cancer experience a substantial reduction in health-related quality of life (HRQOL). At present, studies comparing long-term QOL outcomes for different UD methods, needed to inform evidence-based choices of bladder reconstruction for female patients, are sparse. Our objective was to compare two common UD methods in terms of their HRQOL outcomes in women. Materials and methods: We retrospectively analysed HRQOL in 73 consecutive female bladder cancer patients having undergone orthotopic ileal neobladder (IONB, N = 24) or ileal conduit (IC, N = 49) following RC between 2007 and 2013 in six Italian academic urological centres. Patients had no evidence of tumour recurrence and were actively followed up. Validated Italian versions of the European Organisation for Research and Treatment of Cancer (EORTC) generic (QLQ-C30) and bladder-cancer-specific (QLQ-BLM30) questionnaires were used to evaluate HRQOL. Results: Patients in the IONB group were significantly younger than those in the IC group (median age: 67 and 73 years, respectively, p = 0.02). Barring that, the two groups did not present statistically significant differences in median length of follow-up (43 vs 54 months), pathological stage, grading of the neoplasm, or adjuvant chemo - or radiotherapy. No significant differences in QOL were found between the groups, with the exception of financial difficulties, affecting IONB patients significantly more than IC patients (mean score on a scale of 0–100: 33.3 ± 29.5 vs 18.4 ± 19.3, respectively; p = 0.05). Conclusion: Financial difficulties was the only HRQOL item to differ between the two UD groups.

Published
2019

16. Association of local anaesthetic wounds infiltration and ultrasound transversus abdominal plane (US-TAP) block in patients undergoing robot-assisted radical prostatectomy: A double-blind randomized controlled trial

Author

Cacciamani, G.E., primary, Menestrina, N., additional, Pirozzi, M., additional, Corsi, P., additional, De Marchi, D., additional, Inverardi, D., additional, Processali, T., additional, Trabacchin, N., additional, De Michele, M., additional, Tafuri, A., additional, Sebben, M., additional, Cerruto, M.A., additional, De Marco, V., additional, Migliorini, F., additional, Porcaro, A.B., additional, and Artibani, W., additional

Published
2019
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17. SC325 - The American Society of Anesthesiologists’ (ASA) physical status system classification predicted the risk of postoperative complications at hospital discharge in 1329 consecutive patients treated with radical prostatectomy for clinical prostate cancer

Author

Rizzetto, R., Porcaro, A.B., Amigoni, N., Tafuri, A., Cerrato, C., Bianchi, A., Gallina, S., Orlando, R., Gozzo, A., Migliorini, F., Antoniolli, S. Zecchini, Monaco, C., De Marco, V., Brunelli, M., Cerruto, M.A., Polati, E., and Antonelli, A.

Published
2021
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20. Body Mass Index (BMI) is an independent factor associated with the risk of multiple lymph node invasion in patients undergoing extended pelvic dissection during robot assisted radical prostatectomy

Author

Pirozzi, M., primary, Porcaro, A., additional, Corsi, P., additional, Sebben, M., additional, Tafuri, A., additional, Processali, T., additional, Cacciamani, G., additional, De Marchi, D., additional, Mattevi, D., additional, Amigoni, N., additional, Rizzetto, R., additional, Cerruto, M., additional, Brunelli, M., additional, Siracusano, S., additional, De Marco, V., additional, and Artibani, W., additional

Published
2018
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21. Experimental model of an artificial pneumoperitoneum to measure thermal energy spread during bipolar cauterizing

Author

Siracusano, S., primary, Daffara, C., additional, Muradore, R., additional, Marchioro, G., additional, Scutelnic, D., additional, De Marchi, D., additional, Mariotto, A., additional, Silvesri, A., additional, Brunelli, M., additional, De Marco, V., additional, Porcaro, A., additional, Fiorini, P., additional, and Artibani, W., additional

Published
2018
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23. Health-related Quality of Life After Radical Cystectomy: A Cross-sectional Study With Matched-pair Analysis on Ileal Conduit vs Ileal Orthotopic Neobladder Diversion

Author

Cerruto, M. A., D'Elia, C., Siracusano, S., Saleh, O., Gacci, M., Cacciamani, G., De Marco, V., Porcaro, A. B., Balzarro, M., Niero, M., Lonardi, C., Iafrate, M., Bassi, P., Imbimbo, C., Racioppi, M., Talamini, R., Ciciliato, S., Serni, S., Carini, M., Verze, P., Artibani, W., Bassi P. (ORCID:0000-0002-4313-8427), Racioppi M. (ORCID:0000-0001-9129-8479), Cerruto, M. A., D'Elia, C., Siracusano, S., Saleh, O., Gacci, M., Cacciamani, G., De Marco, V., Porcaro, A. B., Balzarro, M., Niero, M., Lonardi, C., Iafrate, M., Bassi, P., Imbimbo, C., Racioppi, M., Talamini, R., Ciciliato, S., Serni, S., Carini, M., Verze, P., Artibani, W., Bassi P. (ORCID:0000-0002-4313-8427), and Racioppi M. (ORCID:0000-0001-9129-8479)

Abstract

Objective To examine the different and health-related quality of life (HR-QoL) outcomes between ileal conduit (IC) and ileal orthotopic neobladder (IONB) in patients who underwent radical cystectomy (RC), by using validated self-reported cancer-specific instruments. Patients and Methods This retrospective, cross-sectional, multicenter cohort study included 148 and 171 patients with either IC or IONB. HR-QoL was evaluated with Quality of Life Core Questionnaire and bladder module (BLM)-30 European Organisation for Research and Treatment of Cancer questionnaires. Baseline HR-QoL scores were dichotomized at the median to give “good” or “poor” score profiles. A matched-pair analysis compared HR-QoL aspects between 79 IC patients and 79 IONB patients. Results At univariate analysis IONB resulted favorable for physical functioning, emotional functioning, cognitive functioning (CF), fatigue, dyspnea, appetite loss, constipation (CO), and abdominal bloating flatulence (AB). At multivariate analyses, IONB showed better scores for emotional functioning (85 vs 79, P =.023), CF (93 vs 85, P <.001), CO (16 vs 31, P <.001), and AB (12 vs 25, P <.001). A significant worsening of sexual and urinary function was observed for IONB patients in the long-term. At matched-pair analysis, global health status was similar (65 vs 62, P =.385). Significantly better scores were observed in the IONB group for the following items: CF (P =.007), fatigue (P =.003), pain (P =.019), dyspnea (P =.016), CO (P =.001), and AB (P =.00). Conclusion IONB and IC after RC were similar in terms of global health status. IONB provides better results in some aspects of HR-QoL related to bowel function, but a worsening of urinary and sexual functions. Further randomized controlled trials are needed to confirm these data.

Published
2017

26. Addressing the best treatment for non-clear cell renal cell carcinoma (nccRCC): a meta-analysis of randomized clinical trials comparing VEGFR-TKis versus mTORi targeted therapies

Author

Ciccarese, C., primary, Iacovelli, R., additional, Massari, F., additional, Brunelli, M., additional, Bimbatti, D., additional, Fantinel, E., additional, De Marco, V., additional, Porcaro, A.B., additional, Martignoni, G., additional, Artibani, W., additional, and Tortora, G., additional

Published
2017
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28. Feasibility and safety of not placing a drain in the pelvic cavity after robot-assisted radical prostatectomy with or without extended pelvic lymph node dissection: Results of a randomized controlled study

Author

Porcaro, A.B., primary, Siracusano, S., additional, Bizzotto, L., additional, Sebben, M., additional, De Luyk, N., additional, Corsi, P., additional, Tafuri, A., additional, Processali, T., additional, Mattevi, D., additional, Cerruto, M.A., additional, Brunelli, M., additional, Novella, G., additional, De Marco, V., additional, and Artibani, W., additional

Published
2017
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30. Learning from critical internationalisation events. Insights from two fast growing Italian SMEs

Author

S. Albertini, G. Antonelli, B. Balboni, A. Berni, S. Bonesso, G. Bortoluzzi, M. Brumana, D. Campagnolo, L. Cassia, A. Comacchio, S. Consiglio, F. Crisci, C. Dossena, C.E. De Marco, V. Finotto, A. Francesconi, D. Gamba, D. Giacomini, M. Gianecchini, P. Gubitta, M.P. Iacono, F. Izzo, G. Lauto, G. Magnani, M. Martine, B. Masiello, P.A.M. Mazzurana, T. Minola, C. Muzzi, A. Onetti, A. Piccaluga, A. Pisoni, D. Pittino, P. Pressiani, T. Pucci, M. Talaia, A. Tognazzo, A. Tracogna, F. Visintin, L. Zanni, A. Zucchella, Visintin, F, Pittino, D, Francesconi, A., Dossena, Claudia, Magnani, Giacomo, Talaia, M., Pisoni, A., Onetti, A., Zucchella, A., Dossena, C. (ORCID:0000-0002-3657-8782), Magnani, G., S. Albertini, G. Antonelli, B. Balboni, A. Berni, S. Bonesso, G. Bortoluzzi, M. Brumana, D. Campagnolo, L. Cassia, A. Comacchio, S. Consiglio, F. Crisci, C. Dossena, C.E. De Marco, V. Finotto, A. Francesconi, D. Gamba, D. Giacomini, M. Gianecchini, P. Gubitta, M.P. Iacono, F. Izzo, G. Lauto, G. Magnani, M. Martine, B. Masiello, P.A.M. Mazzurana, T. Minola, C. Muzzi, A. Onetti, A. Piccaluga, A. Pisoni, D. Pittino, P. Pressiani, T. Pucci, M. Talaia, A. Tognazzo, A. Tracogna, F. Visintin, L. Zanni, A. Zucchella, Visintin, F, Pittino, D, Francesconi, A., Dossena, Claudia, Magnani, Giacomo, Talaia, M., Pisoni, A., Onetti, A., Zucchella, A., Dossena, C. (ORCID:0000-0002-3657-8782), and Magnani, G.

Abstract

At present, Europe lacks innovative companies, which grow quickly and end up big. This book examines SME growth, innovation and success, to suggest that fast-growing firms could offer a major contribution to the recovery of a European economy. The contributors examine eleven case studies from Italian firms, breaking the book up into three parts: context, actors and strategy. The topics discussed include entrepreneurship and technological clusters, innovative start-ups and growth factors, and family firms as the incubators of new ventures. Students and scholars of entrepreneurship and other related disciplines will find this book to be of interest. It will also be of use to practitioners in the field, working with and alongside SMEs.

Published
2016

31. PT279 - Association of local anaesthetic wounds infiltration and ultrasound transversus abdominal plane (US-TAP) block in patients undergoing robot-assisted radical prostatectomy: A double-blind randomized controlled trial

Author

Cacciamani, G.E., Menestrina, N., Pirozzi, M., Corsi, P., De Marchi, D., Inverardi, D., Processali, T., Trabacchin, N., De Michele, M., Tafuri, A., Sebben, M., Cerruto, M.A., De Marco, V., Migliorini, F., Porcaro, A.B., and Artibani, W.

Published
2019
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36. 1017 Quality of life in 73 women with bladder cancer undergoing ileal orthotopic neobladder and ileal conduit: A multicentre study among long-term survivors

Author

Siracusano, S., primary, Cerruto, M.A., additional, Ciciliato, S., additional, Gacci, M., additional, Simonato, A., additional, D'Elia, C., additional, Porcaro, A.B., additional, De Marco, V., additional, Talamini, R., additional, Toffoli, L., additional, Saleh, O., additional, Visalli, F., additional, Belgrano, E., additional, Niero, M., additional, Lonardi, C., additional, Imbimbo, C., additional, Verze, P., additional, Racioppi, M., additional, Iafrate, M., additional, Cacciamani, G., additional, De Marchi, D., additional, Bassi, P., additional, and Artibani, W., additional

Published
2016
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38. Germline mutation analysis of Tpit in Poodle dogs with ACTH-dependent hyperadrenocorticism

Author

De Marco, V., Carvalho, L.R., Billerbeck, A.E.C., and Mendonça, B.B.

Subjects
cão, dog, ACTH-dependent hyperadrenocorticism, mutação, Tpit, mutation, hiperadrenocorticismo ACTH-dependente
Abstract

There is a high incidence of pituitary-dependent hyperadrenocorticism (PDH) in Poodle dogs, with family members being affected by the disease, suggesting a genetic involvement. Tpit is an obligate transcription factor for the expression of pro-opiomelanocortingene and for corticotroph terminal differentiation. The aim of the present study was to screen the Tpit gene for germline mutations in Poodles with PDH. Fifty Poodle dogs (33 female, 8.71±2.8 years) with PDH and 50 healthy Poodle dogs (32 females, 9.4241 2.8 years) were studied. Genomic DNA was isolated from peripheral blood, amplified by PCR and submitted to automatic sequence. No mutation in the coding region of Tpit was found, whereas the new single nucleotide polymorphism p.S343G, in heterozygous state, was found in the same frequency in both PDH and control groups. We concluded that Tpit gain-of-function mutations are not involved in the etiology of PDH in Poodle dogs. O hiperadrenocorticismo ACTH-dependente (HACAD) apresenta elevada incidência em cães da raça Poodle, sendo que membros da mesma família têm sido acometidos pela doença, sugerindo envolvimento genético. Tpit é um fator de transcrição obrigatório para a expressão do gene da pro-opiomelanocortina e para a diferenciação terminal dos corticotrofos. O objetivo deste trabalho foi pesquisar mutações germinativas no gene Tpit em Poodles com HACAD. Cinquenta cães da raça Poodle, 33 fêmeas, média de idade de 8,71±2,8 anos, com HACAD, e 50 cães Poodles saudáveis, 32 fêmeas, média de idade de 9,4±2,8 anos, foram estudados. Mutações na região codificadora do gene Tpit não foram identificadas. Foi observado um novo polimorfismo em heterozigose, p.S343G, com a mesma frequência no grupo de cães com HACAD e no grupo-controle. Conclui-se que a mutação ativadora no gene Tpit não está envolvida na patogênese do hiperadrenocorticismo ACTH-dependente em cães da raça Poodle.

Published
2012

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