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18 results on '"De Marco, Davide"'

3. The potential for medical therapies to address fistulizing Crohn’s disease: a state-of-the-art review

Author

Shehab, Mohammad, De Marco, Davide, Lakatos, Peter L., and Bessissow, Talat

Abstract

ABSTRACTIntroductionCrohn’s disease (CD) is a chronic, relapsing immune mediated disease, which is one of the two major types of inflammatory bowel disease (IBD). Fistulizing CD poses a significant clinical challenge for physicians. Effective management of CD requires a multidisciplinary approach, involving a gastroenterologist and a GI surgeon while tailoring treatment to each patient’s unique risk factors, clinical representations, and preferences.Areas coveredThis comprehensive review explores the intricacies of fistulizing CD including its manifestations, types, impact on quality of life, management strategies, and novel therapies under investigation.Expert opinionAntibiotics are often used as first-line therapy to treat symptoms. Biologics that selectively target TNF-α, such infliximab (IFX), have shown high efficacy in randomized controlled trials. However, more than 50% of patients lose response to IFX, prompting them to explore alternative strategies. Current options include adalimumab and certolizumab pegol combination therapies, as well as small-molecule drugs targeting Janus kinases such as Upadacitinib. Furthermore, a promising treatment for complex fistulas is mesenchymal stem cells such as Darvadstrocel (Alofisel), an allogeneic stem cell-based therapy. However, surgical interventions are necessary for complex cases or intra-abdominal complications. Setons and LIFT procedures are the most common surgical options.

Published
2024
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7. Arthrodesis in the Charcot foot: a systematic review

Author

Cianni, Luigi, Bocchi, Maria Beatrice, Vitiello, Raffaele, Greco, Tommaso, De Marco, Davide, Masci, G, Maccauro, Giulio, Pitocco, Dario, Perisano, Carlo, Cianni L, Bocchi MB, Vitiello R, Greco T, De Marco D, Maccauro G (ORCID:0000-0002-7359-268X), Pitocco D (ORCID:0000-0002-6220-686X), Perisano C, Cianni, Luigi, Bocchi, Maria Beatrice, Vitiello, Raffaele, Greco, Tommaso, De Marco, Davide, Masci, G, Maccauro, Giulio, Pitocco, Dario, Perisano, Carlo, Cianni L, Bocchi MB, Vitiello R, Greco T, De Marco D, Maccauro G (ORCID:0000-0002-7359-268X), Pitocco D (ORCID:0000-0002-6220-686X), and Perisano C

Abstract

The Charcot foot is a condition characterized by a progressive derangement of the foot. The type of deformity and patient clinical conditions will lead to the proper surgical approach among exostectomy, arthrodesis (through external and/or internal fixation) and amputation. Many authors report good clinical outcomes performing the arthrodesis in Charcot foot; however, the choice of the most appropriate hardware is still an issue. The aim of this study is to analyze the outcomes of different hardware in midfoot and hindfoot Charcot arthrodesis.

Published
2020

8. Effectiveness of ustekinumab dose escalation in Crohn's disease patients with insufficient response to standard-dose subcutaneous maintenance therapy.

Author

Kopylov, Uri, Hanzel, Jurij, Liefferinckx, Claire, De Marco, Davide, Imperatore, Nicola, Plevris, Nikolas, Baston-Rey, Iria, Harris, Richard J, Truyens, Marie, Domislovic, Viktor, Vavricka, Stephan, Biemans, Vince, Myers, Sally, Sebastian, Shaji, Ben-Horin, Shomron, González Lama, Yago, Gilletta, Cyrielle, Ariella, Bar-Gil Shitrit, Zelinkova, Zuzana, Weisshof, Roni, Storan, Darragh, Zittan, Eran, Farkas, Klaudia, Molnar, Tamas, Franchimont, Denis, Cremer, Anneline, Afif, Waqqas, Castiglione, Fabiana, Lees, Charles, Barreiro-de Acosta, Manuel, Lobaton, Triana, Doherty, Glen, Krznaric, Zeljko, Pierik, Marieke, Hoentjen, Frank, Drobne, David, Kopylov, Uri, Hanzel, Jurij, Liefferinckx, Claire, De Marco, Davide, Imperatore, Nicola, Plevris, Nikolas, Baston-Rey, Iria, Harris, Richard J, Truyens, Marie, Domislovic, Viktor, Vavricka, Stephan, Biemans, Vince, Myers, Sally, Sebastian, Shaji, Ben-Horin, Shomron, González Lama, Yago, Gilletta, Cyrielle, Ariella, Bar-Gil Shitrit, Zelinkova, Zuzana, Weisshof, Roni, Storan, Darragh, Zittan, Eran, Farkas, Klaudia, Molnar, Tamas, Franchimont, Denis, Cremer, Anneline, Afif, Waqqas, Castiglione, Fabiana, Lees, Charles, Barreiro-de Acosta, Manuel, Lobaton, Triana, Doherty, Glen, Krznaric, Zeljko, Pierik, Marieke, Hoentjen, Frank, and Drobne, David

Abstract

Ustekinumab is effective in Crohn's disease. However, a substantial proportion of patients will not respond or lose response to ustekinumab. The current evidence to support the effectiveness of dose-optimisation for ustekinumab nonresponse is limited., info:eu-repo/semantics/published

Published
2020

9. What are the benefits of robotic-assisted total knee arthroplasty over conventional manual total knee arthroplasty? A systematic review of comparative studies

Author

Mancino, Fabio, primary, Cacciola, Giorgio, additional, Malahias, Michael-Alexander, additional, De Filippis, Roberto, additional, De Marco, Davide, additional, Di Matteo, Vincenzo, additional, Gu, A, additional, Sculco, Peter K., additional, Maccauro, Giulio, additional, and De Martino, Ivan, additional

Published
2020
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11. Arthrodesis in the Charcot foot: a systematic review

Author

Cianni, Luigi, primary, Bocchi, Maria Beatrice, additional, Vitiello, Raffaele, additional, Greco, Tommaso, additional, De Marco, Davide, additional, Masci, Giulia, additional, Maccauro, Giulio, additional, Pitocco, Dario, additional, and Perisano, Carlo, additional

Published
2020
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13. Effectiveness of ustekinumab dose escalation in Crohn’s disease patients with insufficient response to standard-dose subcutaneous maintenance therapy

Author

Kopylov, Uri, primary, Hanzel, Jurij, additional, Liefferinckx, Claire, additional, De Marco, Davide, additional, Imperatore, Nicola, additional, Plevris, Nikolas, additional, Baston-Rey, Iria, additional, Harris, Richard J., additional, Truyens, Marie, additional, Domislovic, Viktor, additional, Vavricka, Stephan, additional, Biemans, Vince, additional, Myers, Sally, additional, Sebastian, Shaji, additional, Ben-Horin, Shomron, additional, González Lama, Yago, additional, Gilletta, Cyrielle, additional, Ariella, Bar-Gil Shitrit, additional, Zelinkova, Zuzana, additional, Weisshof, Roni, additional, Storan, Darragh, additional, Zittan, Eran, additional, Farkas, Klaudia, additional, Molnar, Tamas, additional, Franchimont, Denis, additional, Cremer, Anneline, additional, Afif, Waqqas, additional, Castiglione, Fabiana, additional, Lees, Charles, additional, Barreiro-de Acosta, Manuel, additional, Lobaton, Triana, additional, Doherty, Glen, additional, Krznaric, Zeljko, additional, Pierik, Marieke, additional, Hoentjen, Frank, additional, and Drobne, David, additional

Published
2020
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16. Dreamweaver CS4

Author

Andrea De Marco, Davide Vasta and Andrea De Marco, Davide Vasta

17. Prevention of postoperative anemia in hip hemiarthroplasty for femoral neck fractures: comparison between local haemostatic agents

Author

Antonio Ziranu, Cesare Meschini, Davide De Marco, Giuseppe Sircana, Maria Serena Oliva, Giusepp Rovere, Andrea Corbingi, Raffaele Vitiello, Giulio Maccauro, Enrico Pola, Ziranu, Antonio, Meschini, Cesare, De Marco, Davide, Sircana, Giuseppe, Oliva, Maria Serena, Rovere, Giusepp, Corbingi, Andrea, Vitiello, Raffaele, Maccauro, Giulio, and Pola, Enrico

Subjects
hip fracture, fibrin sealant, Orthopedics and Sports Medicine, General, tranexamic acid
Abstract

Background Tranexamic acid and fibrin sealant have been shown to be effective in reducing the need for transfusion after hip fracture surgery. Objective The aim of this study was to evaluate the efficacy of local haemostatic agents to reduce the need of postoperative transfusion in elederly patients after hip hemiarthroplasty. Methods All patients admitted to our institution with a diagnosis of proximal femur fracture from September 2018 to March 2021 were involved. Inclusion criteria were: diagnosis of femoral neck fracture, classified as AO 31B2-3, surgical treatment with hip hemiarthroplasty, hemoglobinemia on admission > 8 gr/dL. Patients were divided in four groups Results EVICEL was used on 25 patients, TRANEX was used on 52 patients, standard hemostatic care was used on 73 patients, while post-surgical drain was used on 21 patients. 3 patients were transfused in the EVICEL group while 26 patients were transfused in the control group (p 0,0404), there was also statistical significant difference in the need of perioperative transfusion between EVICEL group and drain group with 10 patients transfused (p 0,0102). Statistical significant differences was found about haemoglobin variation in the first post-operative day between TRANEX group and control group (p 0,000155) and between TRANEX group and drain group (p 0,013) and also between TRANEX group and control group in the third post-operative day (p 0,0004). Conclusion This study demonstrates that the use of both fibrin sealant or TXA can reduce total blood loss and the need of transfusions in geriatric population with intracapsular femur fracture.

Published
2022

18. Non tuberculous mycobacteria related spondylodiscitis: a case report and systematic literature review.

Author

Smimmo A, Perna A, Fantoni M, De Marco D, Velluto C, Proietti L, Sali M, and Tamburrelli FC

Subjects
Discitis diagnosis, Discitis therapy, Female, Humans, Middle Aged, Discitis microbiology, Mycobacterium Infections, Nontuberculous diagnosis, Mycobacterium Infections, Nontuberculous therapy
Abstract

Purpose: Mycobacterium xenopi and Non Tuberculous Mycobacteria (NTM) are rare causes of spondylodiscitis (SD). The aim of this study was to highlight the relevance of considering these pathogens in differential diagnosis of slow growing SD, obtaining the correct diagnosis and evaluating the key points of management and therapy approach., Methods: A case of surgically treated Mycobacterium xenopi SD is reported. A systematic review according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines was performed. The research was conducted on MEDLINE, PubMed and Scopus using as search-terms "vertebral", "spinal", "infection", "spondylodiscitis", "discitis", "osteomyelitis", "atypical", "nontuberculous", "mycobacterium"., Results: After the screening of 444 titles and abstracts, 113 papers were considered eligible for the full-text analysis. Seventy-seven studies that met inclusion criteria were finally included in the review. Overall, including our report, 91 patients affected by NTM SD were analyzed in this systematic review Conclusion: This review highlights the rarity of spinal infections due to NTM and the difficulty of their management. A tailored approach with prolonged antibiotic therapy, eventually associated with surgery in selected cases were suggested for the treatment of NTM infections.

Published
2020

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