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2. Tobacco Patterns and Risk of Chronic Obstructive Pulmonary Disease: Results From a Cross-Sectional Study

Author

Rey-Brandariz, Julia, Pérez-Ríos, Mónica, Ahluwalia, Jasjit S., Beheshtian, Kiana, Fernández-Villar, Alberto, Represas-Represas, Cristina, Piñeiro, María, Alfageme, Inmaculada, Ancochea, Julio, Soriano, Joan B., Casanova, Ciro, Cosío, Borja G., García-Río, Francisco, Miravitlles, Marc, de Lucas, Pilar, Rodríguez González-Moro, José Miguel, Soler-Cataluña, Juan José, and Ruano-Ravina, Alberto

Published
2023
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7. Occupational Exposures, Chronic Obstructive Pulmonary Disease and Tomographic Findings in the Spanish Population.

Author

Loeb, Eduardo, Zock, Jan-Paul, Miravitlles, Marc, Rodríguez, Esther, Kromhout, Hans, Vermeulen, Roel, Soler-Cataluña, Juan José, Soriano, Joan B., García-Río, Francisco, de Lucas, Pilar, Alfageme, Inmaculada, Casanova, Ciro, González-Moro, José Rodríguez, Ancochea, Julio, Cosío, Borja G., and Ferrer Sancho, Jaume

Subjects
CHRONIC obstructive pulmonary disease, OCCUPATIONAL exposure, LUNGS, POISONOUS gases, SPIROMETRY
Abstract

Self-reported occupational exposure was previously associated with COPD in the Spanish population. This study aimed to analyse the relationship between occupational exposure to various chemical and biological agents, COPD, emphysema, and the bronchial wall area, which was determined by lung computed tomography (CT) in 226 individuals with COPD and 300 individuals without COPD. Lifetime occupational exposures were assessed using the ALOHA(+) job exposure matrix, and CT and spirometry were also performed. COPD was associated with high exposure to vapours, gases, dust and fumes (VGDF) (OR 2.25 95% CI 1.19–4.22), biological dust (OR 3.01 95% CI 1.22–7.45), gases/fumes (OR 2.49 95% CI 1.20–5.17) and with exposure to various types of solvents. High exposure to gases/fumes, chlorinated solvents and metals (coefficient 8.65 95% CI 1.21–16.09, 11.91 95%CI 0.46- 23.36, 14.45 95% CI 4.42–24.49, respectively) and low exposure to aromatic solvents (coefficient 8.43 95% CI 1.16–15.70) were associated with a low 15th percentile of lung density indicating emphysema. We conclude that occupational exposure to several specific agents is associated with COPD and emphysema in the Spanish population. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Changes and Clinical Consequences of Smoking Cessation in Patients With COPD: A Prospective Analysis From the CHAIN Cohort

Author

Martínez-González, Cristina, Casanova, Ciro, de-Torres, Juan P., Marín, José M., de Lucas, Pilar, Fuster, Antonia, Cosío, Borja G., Calle, Myriam, Peces-Barba, Germán, Solanes, Ingrid, Agüero, Ramón, Feu-Collado, Nuria, Alfageme, Inmaculada, Romero Plaza, Amparo, Balcells, Eva, de Diego, Alfredo, Marín Royo, Margarita, Moreno, Amalia, Llunell Casanovas, Antonia, Galdiz, Juan B., Golpe, Rafael, Lacárcel Bautista, Celia, Cabrera, Carlos, Marin, Alicia, Soriano, Joan B., and Lopez-Campos, Jose Luis

Published
2018
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16. Protective Cardiovascular Effect of Sleep Apnea Severity in Obesity Hypoventilation Syndrome

Author

García-Ledesma, Estefanía, Sánchez-Quiroga, M-Ángeles, Ordax, Estrella, González-Mangado, Nicolás, Troncoso, Maria F., Martinez-Martinez, Maria-Ángeles, Cantalejo, Olga, Ojeda, Elena, Carrizo, Santiago J., Gallego, Begoña, Pallero, Mercedes, Ramón, Mª Antonia, Díaz-de-Atauri, Josefa, Muñoz-Méndez, Jesús, Senent, Cristina, Sancho-Chust, Jose N., Ribas-Solis, Francisco Javier, Barrot, Emilia, Benítez, José M., Sanchez-Gómez, Jesús, Golpe, Rafael, Santiago-Recuerda, Ana, Gomez, Silvia, Bengoa, Mónica, Masa, Juan F., Corral, Jaime, Romero, Auxiliadora, Caballero, Candela, Terán-Santos, Joaquin, Alonso-Álvarez, Maria L., Gomez-Garcia, Teresa, González, Mónica, López-Martín, Soledad, De Lucas, Pilar, Marin, José M., Marti, Sergi, Díaz-Cambriles, Trinidad, Chiner, Eusebi, Merchan, Miguel, Egea, Carlos, Obeso, Ana, and Mokhlesi, Babak

Published
2016
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17. Mid- and Long-term Efficacy of Non-invasive Ventilation in Obesity Hypoventilation Syndrome: The Pickwick's Study

Author

López-Jiménez, María J., Masa, Juan F., Corral, Jaime, Terán, Joaquín, Ordaz, Estrella, Troncoso, Maria F., González-Mangado, Nicolás, González, Mónica, Lopez-Martínez, Soledad, De Lucas, Pilar, Marín, José M., Martí, Sergi, Díaz-Cambriles, Trinidad, Díaz-de-Atauri, Josefa, Chiner, Eusebi, Aizpuru, Felipe, Egea, Carlos, Romero, Auxiliadora, Benítez, José M., Sánchez-Gómez, Jesús, Golpe, Rafael, Santiago-Recuerda, Ana, Gómez, Silvia, Barbe, Ferrán, and Bengoa, Mónica

Published
2016
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18. Eficacia a medio y largo plazo de la ventilación no invasiva en el síndrome de hipoventilación-obesidad (estudio Pickwick)

Author

López-Jiménez, María José, Masa, Juan F., Corral, Jaime, Terán, Joaquín, Ordaz, Estrella, Troncoso, Maria F., González-Mangado, Nicolás, González, Mónica, Lopez-Martínez, Soledad, De Lucas, Pilar, Marín, José M., Martí, Sergi, Díaz-Cambriles, Trinidad, Díaz-de-Atauri, Josefa, Chiner, Eusebi, Aizpuru, Felipe, Egea, Carlos, Romero, Auxiliadora, Benítez, José M., Sánchez-Gómez, Jesús, Golpe, Rafael, Santiago-Recuerda, Ana, Gómez, Silvia, Barbe, Ferrán, and Bengoa, Mónica

Published
2016
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19. Defining the Asthma-COPD Overlap Syndrome in a COPD Cohort

Author

Calvo Bonachera, José, Lacárcel Bautista, Celia, Domenech, Adolfo, Guzmán, Rosirys, Irigaray, Rosa, Zamora, Meritxell López, Ríos, Angel, Córdova, Rocío, López, Carlos Cabrera, Acosta, Alejandro Sánchez, González, Juan Abreu, Balbin, Ramón Agüero, Balcells, Eva, Campos, Elena Miguel, Marin, Alicia, Casanova, Antonia Llunel, Moreno, Amalia, Márquez Pérez, Francisca Lourdes, Riesco Miranda, Juan Antonio, Rodríguez, Julia Tabara, Gómez, Rafael Golpe, de Miguel Díez, Javier, Río, Francisco García, Lobato, Salvador Díaz, Galdiz Iturri, Juan Bautista, Royo, Margarita Marín, de Diego Damia, Alfredo, Cosio, Borja G., Soriano, Joan B., López-Campos, Jose Luis, Calle-Rubio, Myriam, Soler-Cataluna, Juan José, de-Torres, Juan P., Marín, Jose M., Martínez-Gonzalez, Cristina, de Lucas, Pilar, Mir, Isabel, Peces-Barba, Germán, Feu-Collado, Nuria, Solanes, Ingrid, Alfageme, Inmaculada, and Casanova, Ciro

Published
2016
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20. Tobacco Patterns and Risk of Chronic Obstructive Pulmonary Disease: Results From a Cross-Sectional Study

Author

Universidade de Santiago de Compostela. Departamento de Psiquiatría, Radioloxía, Saúde Pública, Enfermaría e Medicina, Rey-Brandariz, Julia, Pérez-Ríos, Mónica, Ahluwalia, Jasjit S., Beheshtian, Kiana, Fernández-Villar, Alberto, Represas-Represas, Cristina, Piñeiro, María, Alfageme, Inmaculada, Ancochea, Julio, Soriano, Joan B., Casanova, Ciro, Cosío, Borja G., García-Río, Francisco, Miravitlles, Marc, de Lucas, Pilar, Rodríguez González-Moro, José Miguel, Soler-Cataluña, Juan José, Ruano Raviña, Alberto, Universidade de Santiago de Compostela. Departamento de Psiquiatría, Radioloxía, Saúde Pública, Enfermaría e Medicina, Rey-Brandariz, Julia, Pérez-Ríos, Mónica, Ahluwalia, Jasjit S., Beheshtian, Kiana, Fernández-Villar, Alberto, Represas-Represas, Cristina, Piñeiro, María, Alfageme, Inmaculada, Ancochea, Julio, Soriano, Joan B., Casanova, Ciro, Cosío, Borja G., García-Río, Francisco, Miravitlles, Marc, de Lucas, Pilar, Rodríguez González-Moro, José Miguel, Soler-Cataluña, Juan José, and Ruano Raviña, Alberto

Abstract

Introduction There is still uncertainty about which aspects of cigarette smoking influence the risk of Chronic Obstructive Pulmonary Disease (COPD). The aim of this study was to estimate the COPD risk as related to duration of use, intensity of use, lifetime tobacco consumption, age of smoking initiation and years of abstinence. Methods We conducted an analytical cross-sectional study based on data from the EPISCAN-II study (n = 9092). All participants underwent a face-to-face interview and post-bronchodilator spirometry was performed. COPD was defined as post-bronchodilator FEV1/FVC < 70%. Parametric and nonparametric logistic regression models with generalized additive models were used. Results 8819 persons were included; 858 with COPD and 7961 without COPD. The COPD risk increased with smoking duration up to ≥50 years [OR 3.5 (95% CI: 2.3–5.4)], with smoking intensity up to ≥39 cig/day [OR 10.1 (95% CI: 5.3–18.4)] and with lifetime tobacco consumption up to >29 pack-years [OR 3.8 (95% CI: 3.1–4.8)]. The COPD risk for those who started smoking at 22 or later was 0.9 (95% CI: 0.6–1.4). The risk of COPD decreased with increasing years of cessation. In comparison with both never smokers and current smokers, the lowest risk of COPD was found after 15–25 years of abstinence. Conclusion COPD risk increases with duration, intensity, and lifetime tobacco consumption and decreases importantly with years of abstinence. Age at smoking initiation shows no effect. After 15–25 years of cessation, COPD risk could be equal to that of a never smoker. This work suggests that the time it takes to develop COPD in a smoker is about 30 years

Published
2023

21. Respiratory symptoms and their determinants in the general Spanish population: changes over 20 years

Author

Miravitlles, Marc, Soler-Cataluña, Juan José, Soriano, Joan B., García-Rio, Francisco, de Lucas, Pilar, Alfageme, Inmaculada, Casanova, Ciro, Rodríguez González-Moro, José Miguel, Sánchez Herrero, María Guadalupe, Ancochea, Julio, Cosio, Borja G, Universitat Autònoma de Barcelona, [Miravitlles, Marc] Hosp Univ Vall Hebron, Dept Pneumol, Vall dHebron Inst Recerca, Barcelona, Spain, [Miravitlles, Marc] Inst Salud Carlos III, CIBER Enfermedades Respiratorias, Madrid, Spain, [Jose Soler-Cataluna, Juan] Inst Salud Carlos III, CIBER Enfermedades Respiratorias, Madrid, Spain, [Soriano, Joan B.] Inst Salud Carlos III, CIBER Enfermedades Respiratorias, Madrid, Spain, [Garcia-Rio, Francisco] Inst Salud Carlos III, CIBER Enfermedades Respiratorias, Madrid, Spain, [Ancochea, Julio] Inst Salud Carlos III, CIBER Enfermedades Respiratorias, Madrid, Spain, [Cosio, Borja G.] Inst Salud Carlos III, CIBER Enfermedades Respiratorias, Madrid, Spain, [Jose Soler-Cataluna, Juan] Hosp Arnau Vilanova Lliria, Serv Neumol, Valencia, Spain, [Soriano, Joan B.] Hosp Univ Princesa, Serv Neumol, Madrid, Spain, [Ancochea, Julio] Hosp Univ Princesa, Serv Neumol, Madrid, Spain, [Soriano, Joan B.] Univ Autonoma Madrid, Madrid, Spain, [Ancochea, Julio] Univ Autonoma Madrid, Madrid, Spain, [Garcia-Rio, Francisco] Hosp Univ Paz IdiPAZ, Serv Neumol, Madrid, Spain, [De Lucas, Pilar] Hosp Gen Gregorio Maranon, Serv Neumol, Madrid, Spain, [Alfageme, Inmaculada] Univ Seville, Hosp Univ Virgen Valme, Unidad Gest Clin Neumol, Seville, Spain, [Casanova, Ciro] Hosp Univ Nuestra Senora Candelaria, Serv Neumol, Tenerife, Spain, [Rodriguez Gonzalez-Moro, Jose Miguel] Univ Alcala, Hosp Univ Principe Asturias Alcala De Henares, Serv Neumol, Madrid, Spain, [Sanchez, Guadalupe] GSK, Dept Med, Madrid, Spain, [Cosio, Borja G.] Hosp Univ Son Espases IdISBa, Serv Neumol, Palma de Mallorca, Spain, Institut Català de la Salut, [Miravitlles M] Servei de Pneumologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain. [Soler-Cataluña JJ] CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain. Servicio de Neumología, Hospital Arnau de Vilanova-Lliria, Valencia, Spain. [Soriano JB] CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain. Servicio de Neumología, Hospital Universitario La Princesa, and Universidad Autónoma de Madrid, Madrid, Spain. [García-Río F] CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain. Servicio de Neumología, Hospital Universitario La Paz-IdiPAZ, Madrid, Spain. [de Lucas P] Servicio de Neumología, Hospital General Gregorio Marañon, Madrid, Spain. [Alfageme I] Unidad de Gestión Clínica de Neumología, Hospital Universitario Virgen de Valme, Universidad de Sevilla, Seville, Spain, and Vall d'Hebron Barcelona Hospital Campus

Subjects
Pulmonary and Respiratory Medicine, Questionnaire, Other subheadings::Other subheadings::/epidemiology [Other subheadings], Otros calificadores::Otros calificadores::/epidemiología [Otros calificadores], técnicas de investigación::métodos epidemiológicos::recopilación de datos::estadísticas vitales::morbilidad::prevalencia [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], Community, Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Morbidity::Prevalence [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT], Physical-activity survey, Scale, Dyspnea, Respiratory Tract Diseases::Lung Diseases [DISEASES], Validation, Adults, Pulmons - Malalties - Epidemiologia, enfermedades respiratorias::enfermedades pulmonares [ENFERMEDADES], Copd, Mortality
Abstract

BackgroundFew large epidemiological studies have analysed the prevalence of respiratory symptoms and their determinants in the general adult population. We investigated the prevalence and determinants of respiratory symptoms and compared their prevalence with that of two previous studies conducted in 1999 and 2009.MethodEPISCAN II was a multicentre, cross-sectional, population-based epidemiological study in individuals older than 40 years.ResultsA total of 9092 individuals were included. Up to 47.5% reported at least one respiratory symptom, being more frequent in women than in men (49.4%versus45.5%, p=0.0002) and with wheezing being the most frequent (33.7%) followed by dyspnoea (26.8%). The presence of any symptom was associated with female sex, higher body mass index (BMI), lower forced expiratory volume in 1 s (FEV1% pred), reduced physical activity, a higher Charlson index and the presence of anxiety and depression. Smoking was also significantly associated with having at least one respiratory symptom in a dose–response fashion (OR: 1.415, 1.916, 2.192 and 2.987 for 0–10, 10–20, 20–30 and >30 pack-years, respectively, all pConclusionsApproximately half of the adult Spanish population have respiratory symptoms and this prevalence has remained quite stable over the last 20 years. Smoking remains the main factor associated with respiratory symptoms, but female sex, comorbidities, high BMI and low FEV1and low physical activity are also significantly associated with respiratory symptoms.

Published
2022

26. Prevalence of reduced lung diffusing capacity and CT scan findings in smokers without airflow limitation : a population-based study

Author

García-Rio, Francisco, Miravitlles, Marc, Soriano, Joan B, Cosio, Borja G, Soler-Cataluña, Juan José, Casanova, Ciro, de Lucas, Pilar, Alfageme, Inmaculada, Rodríguez González-Moro, José Miguel, Sánchez Herrero, María Guadalupe, Ancochea, Julio, Universitat Autònoma de Barcelona, Institut Català de la Salut, [Garcia-Rio F] Servicio de Neumología, Hospital Universitario La Paz-IdiPAZ, Universidad Autónoma de Medicina, Madrid, Spain. Centro de Investigación Biomédica en Red en Enfermedades Respiratorias (CIBERES), Madrid, Spain. [Miravitlles M] Centro de Investigación Biomédica en Red en Enfermedades Respiratorias (CIBERES), Madrid, Spain. Servei de Pneumologia, Vall d'Hebron Hospital Universitari, Barcelona, Spain. Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain. [Soriano JB] Centro de Investigación Biomédica en Red en Enfermedades Respiratorias (CIBERES), Madrid, Spain. Servicio de Neumología, Hospital Universitario La Princesa, Madrid, Spain. Universidad Autónoma de Madrid, Madrid, Spain. [Cosío BG] Centro de Investigación Biomédica en Red en Enfermedades Respiratorias (CIBERES), Madrid, Spain. Servicio de Neumología, Hospital Universitario Son Espases-IdiSBa, Palma de Mallorca, Spain. [Soler-Cataluña JJ] Centro de Investigación Biomédica en Red en Enfermedades Respiratorias (CIBERES), Madrid, Spain. Servicio de Neumología, Hospital Arnau de Vilanova-Lliria, Departamento de Medicina, Universitat de València, Valencia, Spain. [Casanova C] Centro de Investigación Biomédica en Red en Enfermedades Respiratorias (CIBERES), Madrid, Spain. Pulmonary Deparment-Research Unit, Hospital Universitario Nuestra Señora de Candelaria, Universidad de La Laguna, Tenerife, Spain, and Vall d'Hebron Barcelona Hospital Campus

Subjects
Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Image Interpretation, Computer-Assisted::Tomography, X-Ray Computed [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT], Pulmonary and Respiratory Medicine, Tobacco and the lung, Pulmons - Tomografia, diagnóstico::técnicas y procedimientos diagnósticos::diagnóstico por imagen::interpretación de imágenes asistida por ordenador::tomografía computarizada por rayos X [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], Lung Physiology, técnicas de investigación::métodos epidemiológicos::recopilación de datos::estadísticas vitales::morbilidad::prevalencia [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], personas::fumadores [DENOMINACIONES DE GRUPOS], Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Morbidity::Prevalence [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT], Imaging/CT MRI etc, Inorganic Chemicals::Carbon Compounds, Inorganic::Carbon Monoxide [CHEMICALS AND DRUGS], Fumadors, Monòxid de carboni, Persons::Smokers [NAMED GROUPS], compuestos inorgánicos::compuestos inorgánicos del carbono::monóxido de carbono [COMPUESTOS QUÍMICOS Y DROGAS], Exercise
Abstract

BackgroundPopulation distribution of reduced diffusing capacity of the lungs for carbon monoxide (DLCO) in smokers and main consequences are not properly recognised. The objectives of this study were to describe the prevalence of reduced DLCO in a population-based sample of current and former smoker subjects without airflow limitation and to describe its morphological, functional and clinical implications.MethodsA sample of 405 subjects aged 40 years or older with postbronchodilator forced expiratory volume in 1 s/forced vital capacity (FVC) >0.70 was obtained from a random population-based sample of 9092 subjects evaluated in the EPISCAN II study. Baseline evaluation included clinical questionnaires, exhaled carbon monoxide (CO) measurement, spirometry, DLCO determination, 6 min walk test, routine blood analysis and low-dose CT scan with evaluation of lung density and airway wall thickness.ResultsIn never, former and current smokers, prevalence of reduced DLCO was 6.7%, 14.4% and 26.7%, respectively. Current and former smokers with reduced DLCO without airflow limitation were younger than the subjects with normal DLCO, and they had greater levels of dyspnoea and exhaled CO, greater pulmonary artery diameter and lower spirometric parameters, 6 min walk distance, daily physical activity and plasma albumin levels (all pConclusionReduced DLCO is a frequent disorder among smokers without airflow limitation, associated with decreased exercise capacity and with CT findings suggesting that it may be a marker of smoking-induced early vascular damage.Trial registration numberNCT03028207.

Published
2023

27. Prevalence of reduced lung diffusing capacity and CT scan findings in smokers without airflow limitation: a population-based study

Author

Garcia-Rio, Francisco, primary, Miravitlles, Marc, additional, Soriano, Joan B, additional, Cosío, Borja G, additional, Soler-Cataluña, Juan José, additional, Casanova, Ciro, additional, de Lucas, Pilar, additional, Alfageme, Inmaculada, additional, Rodríguez González-Moro, José Miguel, additional, Sánchez Herrero, María Guadalupe, additional, and Ancochea, Julio, additional

Published
2023
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28. Unravelling young COPD and pre-COPD in the general population

Author

Cosío, Borja G., primary, Casanova, Ciro, additional, Soler-Cataluña, Juan José, additional, Soriano, Joan B., additional, García-Río, Francisco, additional, de Lucas, Pilar, additional, Alfageme, Inmaculada, additional, Rodríguez González-Moro, José Miguel, additional, Sánchez, Guadalupe, additional, Ancochea, Julio, additional, and Miravitlles, Marc, additional

Published
2022
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29. Respiratory symptoms and their determinants in the general Spanish population: changes over 20 years

Author

Miravitlles, Marc, primary, Soler-Cataluña, Juan José, additional, Soriano, Joan B., additional, García-Río, Francisco, additional, de Lucas, Pilar, additional, Alfageme, Inmaculada, additional, Casanova, Ciro, additional, Rodríguez González-Moro, José Miguel, additional, Sánchez, Guadalupe, additional, Ancochea, Julio, additional, and Cosío, Borja G., additional

Published
2022
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32. Defining the Asthma-COPD Overlap Syndrome in a COPD Cohort

Author

Cosio, Borja G., Soriano, Joan B., López-Campos, Jose Luis, Calle-Rubio, Myriam, Soler-Cataluna, Juan José, de-Torres, Juan P., Marín, Jose M., Martínez-Gonzalez, Cristina, de Lucas, Pilar, Mir, Isabel, Peces-Barba, Germán, Feu-Collado, Nuria, Solanes, Ingrid, Alfageme, Inmaculada, Casanova, Ciro, Calvo Bonachera, José, Lacárcel Bautista, Celia, Domenech, Adolfo, Guzmán, Rosirys, Irigaray, Rosa, Zamora, Meritxell López, Ríos, Angel, Córdova, Rocío, López, Carlos Cabrera, Acosta, Alejandro Sánchez, González, Juan Abreu, Balbin, Ramón Agüero, Balcells, Eva, Campos, Elena Miguel, Marin, Alicia, Casanova, Antonia Llunel, Moreno, Amalia, Márquez Pérez, Francisca Lourdes, Riesco Miranda, Juan Antonio, Rodríguez, Julia Tabara, Gómez, Rafael Golpe, de Miguel Díez, Javier, Río, Francisco García, Lobato, Salvador Díaz, Galdiz Iturri, Juan Bautista, Royo, Margarita Marín, and de Diego Damia, Alfredo

Published
2016
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35. The burden of COPD in young individuals: results from EPISCAN II

Author

García Cosío Piqueras, Borja, primary, Casanova, Ciro, additional, Soriano, Joan B, additional, Alfageme, Inmaculada, additional, Miravitlles, Marc, additional, De Lucas, Pilar, additional, Soler-Cataluña, Juan Jose, additional, García-Río, Francisco, additional, Rodriguez Gonzalez-Moro, Jose Miguel, additional, Sanchez-Herrero, Guadalupe, additional, and Ancochea, Julio, additional

Published
2021
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40. Late Breaking Abstract - A New study of the Prevalence of COPD in Spain: EPISCAN II

Author

Soriano, Joan Bautista, primary, Alfageme, Inmaculada, additional, Miravitlles, Marc, additional, De Lucas, Pilar, additional, Soler-Cataluña, Juan José, additional, García-Río, Francisco, additional, Casanova, Ciro, additional, Rodríguez González-Moro, José Miguel, additional, Cosío, Borja G, additional, Sánchez, Guadalupe, additional, and Ancochea, Julio, additional

Published
2019
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43. Echocardiographic changes with non-invasive ventilation and CPAP in obesity hypoventilation syndrome

Author

Corral, Jaime, Mogollon, Maria Victoria, Sánchez-Quiroga, M-Ángeles, Gómez de Terreros, Javier, Romero, Auxiliadora, Caballero, Candela, Teran-Santos, Joaquin, Alonso-Álvarez, María L, Gómez-García, Teresa, González, Mónica, López-Martínez, Soledad, de Lucas, Pilar, Marin, José M, Romero, Odile, Díaz-Cambriles, Trinidad, Chiner, Eusebi, Egea, Carlos, Lang, Roberto M, Mokhlesi, Babak, Masa, Juan F, and Spanish Sleep Network

Subjects
Pulmonary and Respiratory Medicine, Adult, Male, medicine.medical_specialty, Adolescent, Polysomnography, 030204 cardiovascular system & hematology, Left ventricular hypertrophy, law.invention, Body Mass Index, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Internal medicine, medicine.artery, Obesity Hypoventilation Syndrome, Medicine, Humans, Trial registration, Life Style, Aged, Obesity hypoventilation syndrome, Aged, 80 and over, Noninvasive Ventilation, Continuous Positive Airway Pressure, business.industry, Walk distance, Middle Aged, medicine.disease, Pulmonary hypertension, Echocardiography, Doppler, Treatment Outcome, 030228 respiratory system, Spain, Spirometry, Pulmonary artery, Breathing, Cardiology, non invasive ventilation, Quality of Life, Female, business, sleep apnoea, Follow-Up Studies
Abstract

RationaleDespite a significant association between obesity hypoventilation syndrome (OHS) and cardiac dysfunction, no randomised trials have assessed the impact of non-invasive ventilation (NIV) or CPAP on cardiac structure and function assessed by echocardiography.ObjectivesWe performed a secondary analysis of the data from the largest multicentre randomised controlled trial of OHS (Pickwick project, n=221) to determine the comparative efficacy of 2 months of NIV (n=71), CPAP (n=80) and lifestyle modification (control group, n=70) on structural and functional echocardiographic changes.MethodsConventional transthoracic two-dimensional and Doppler echocardiograms were obtained at baseline and after 2 months. Echocardiographers at each site were blinded to the treatment arms. Statistical analysis was performed using intention-to-treat analysis.ResultsAt baseline, 55% of patients had pulmonary hypertension and 51% had evidence of left ventricular hypertrophy. Treatment with NIV, but not CPAP, lowered systolic pulmonary artery pressure (−3.4 mm Hg, 95% CI −5.3 to –1.5; adjusted P=0.025 vs control and P=0.033 vs CPAP). The degree of improvement in systolic pulmonary artery pressure was greater in patients treated with NIV who had pulmonary hypertension at baseline (−6.4 mm Hg, 95% CI −9 to –3.8). Only NIV therapy decreased left ventricular hypertrophy with a significant reduction in left ventricular mass index (−5.7 g/m2; 95% CI −11.0 to –4.4). After adjusted analysis, NIV was superior to control group in improving left ventricular mass index (P=0.015). Only treatment with NIV led to a significant improvement in 6 min walk distance (32 m; 95% CI 19 to 46).ConclusionIn patients with OHS, medium-term treatment with NIV is more effective than CPAP and lifestyle modification in improving pulmonary hypertension, left ventricular hypertrophy and functional outcomes. Long-term studies are needed to confirm these results.Trial registration numberPre-results, NCT01405976 (https://clinicaltrials.gov/).

Published
2018

44. Non-invasive ventilation in obesity hypoventilation syndrome without severe obstructive sleep apnoea

Author

Masa, Juan F, Corral, Jaime, Caballero, Candela, Barrot, Emilia, Terán-Santos, Joaquin, Alonso-Álvarez, Maria L, Gomez-Garcia, Teresa, González, Mónica, López-Martín, Soledad, De Lucas, Pilar, Marin, José M, Marti, Sergi, Díaz-Cambriles, Trinidad, Chiner, Eusebi, Egea, Carlos, Miranda, Erika, Mokhlesi, Babak, Spanish Sleep Network, García-Ledesma, Estefanía, Sánchez-Quiroga, M-Ángeles, Ordax, Estrella, González-Mangado, Nicolás, Troncoso, Maria F, Martinez-Martinez, Maria-Ángeles, Cantalejo, Olga, Ojeda, Elena, Carrizo, Santiago J, Gallego, Begoña, Pallero, Mercedes, Ramón, M Antonia, Díaz-de-Atauri, Josefa, Muñoz-Méndez, Jesús, Senent, Cristina, Sancho-Chust, Jose N, Ribas-Solís, Francisco J, Romero, Auxiliadora, Benítez, José M, Sanchez-Gómez, Jesús, Golpe, Rafael, Santiago-Recuerda, Ana, Gomez, Silvia, and Bengoa, Mónica

Subjects
Non-Invasive Ventilation, Pulmonary and Respiratory Medicine, Spirometry, Male, medicine.medical_specialty, Partial Pressure, Polysomnography, Vital Capacity, Blood Pressure, 03 medical and health sciences, Sleep apnoea, 0302 clinical medicine, Quality of life, Forced Expiratory Volume, Obesity Hypoventilation Syndrome, medicine, Humans, 030212 general & internal medicine, Prospective cohort study, Intensive care medicine, Life Style, Aged, Obesity hypoventilation syndrome, Aged, 80 and over, Sleep Apnea, Obstructive, Noninvasive Ventilation, medicine.diagnostic_test, business.industry, Non invasive ventilation, Carbon Dioxide, Middle Aged, medicine.disease, respiratory tract diseases, Respiratory Function Tests, Clinical trial, Blood pressure, Treatment Outcome, 030228 respiratory system, Emergency medicine, Arterial blood, Female, Respiratory Insufficiency, business
Abstract

Background Non-invasive ventilation (NIV) is an effective form of treatment in patients with obesity hypoventilation syndrome (OHS) who have concomitant severe obstructive sleep apnoea (OSA). However, there is a paucity of evidence on the efficacy of NIV in patients with OHS without severe OSA. We performed a multicentre randomised clinical trial to determine the comparative efficacy of NIV versus lifestyle modification (control group) using daytime arterial carbon dioxide tension (PaCO2) as the main outcome measure. Methods Between May 2009 and December 2014 we sequentially screened patients with OHS without severe OSA. Participants were randomised to NIV versus lifestyle modification and were followed for 2 months. Arterial blood gas parameters, clinical symptoms, health-related quality of life assessments, polysomnography, spirometry, 6-min walk distance test, blood pressure measurements and healthcare resource utilisation were evaluated. Statistical analysis was performed using intention-to-treat analysis. Results A total of 365 patients were screened of whom 58 were excluded. Severe OSA was present in 221 and the remaining 86 patients without severe OSA were randomised. NIV led to a significantly larger improvement in PaCO2 of −6 (95% CI −7.7 to −4.2) mm Hg versus −2.8 (95% CI −4.3 to −1.3) mm Hg, (p

Published
2016

45. Echocardiographic changes with non-invasive ventilation and CPAP in obesity hypoventilation syndrome

Author

Corral, Jaime, primary, Mogollon, Maria Victoria, additional, Sánchez-Quiroga, M-Ángeles, additional, Gómez de Terreros, Javier, additional, Romero, Auxiliadora, additional, Caballero, Candela, additional, Teran-Santos, Joaquin, additional, Alonso-Álvarez, María L, additional, Gómez-García, Teresa, additional, González, Mónica, additional, López-Martínez, Soledad, additional, de Lucas, Pilar, additional, Marin, José M, additional, Romero, Odile, additional, Díaz-Cambriles, Trinidad, additional, Chiner, Eusebi, additional, Egea, Carlos, additional, Lang, Roberto M, additional, Mokhlesi, Babak, additional, and Masa, Juan F, additional

Published
2017
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46. Echocardiographic changes with positive airway pressure in obesity hypoventilation syndrome. Pickwick study

Author

Sanchez Quiroga, Mª Ángeles, primary, Mogollón, Mª Victoria, additional, Gómez de Terreros, Fco. Javier, additional, Corral, Jaime, additional, Romero, Auxiliadora, additional, Caballero, Candela, additional, Terán-Santos, Joaquín, additional, Alonso-Álvarez, Maria L, additional, Gomez-Garcia, Teresa, additional, González, Mónica, additional, López-Martínez, Soledad, additional, de Lucas, Pilar, additional, Marin, José M., additional, Díaz-Cambriles, Trinidad, additional, Marti, Sergi, additional, Egea, Carlos, additional, Mokhlesi, Babak, additional, Barca, Javier, additional, and Masa, Juan F., additional

Published
2017
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47. Distribution and Outcomes of a Phenotype-Based Approach to Guide COPD Management : Results from the CHAIN Cohort

Author

Cosio, Borja G., Soriano, Joan B., López-Campos, Jose Luis, Calle Rubio, Myriam, Soler, Juan José, de-Torres, Juan Pablo, Marín, Jose Maria, Martínez, Cristina, de Lucas, Pilar, Mir, Isabel, Peces-Barba, Germán, Feu-Collado, Nuria, Solanes García, Ingrid, Alfageme, Inmaculada, Universitat Autònoma de Barcelona, Cosio, Borja G., Soriano, Joan B., López-Campos, Jose Luis, Calle Rubio, Myriam, Soler, Juan José, de-Torres, Juan Pablo, Marín, Jose Maria, Martínez, Cristina, de Lucas, Pilar, Mir, Isabel, Peces-Barba, Germán, Feu-Collado, Nuria, Solanes García, Ingrid, Alfageme, Inmaculada, and Universitat Autònoma de Barcelona

Abstract

The Spanish guideline for COPD (GesEPOC) recommends COPD treatment according to four clinical phenotypes: non-exacerbator phenotype with either chronic bronchitis or emphysema (NE), asthma-COPD overlap syndrome (ACOS), frequent exacerbator phenotype with emphysema (FEE) or frequent exacerbator phenotype with chronic bronchitis (FECB). However, little is known on the distribution and outcomes of the four suggested phenotypes. We aimed to determine the distribution of these COPD phenotypes, and their relation with one-year clinical outcomes. We followed a cohort of well-characterized patients with COPD up to one-year. Baseline characteristics, health status (CAT), BODE index, rate of exacerbations and mortality up to one year of follow-up were compared between the four phenotypes. Overall, 831 stable COPD patients were evaluated. They were distributed as NE, 550 (66.2%); ACOS, 125 (15.0%); FEE, 38 (4.6%); and FECB, 99 (11.9%); additionally 19 (2.3%) COPD patients with frequent exacerbations did not fulfill the criteria for neither FEE nor FECB. At baseline, there were significant differences in symptoms, FEV and BODE index (all p<0.05). The FECB phenotype had the highest CAT score (17.1±8.2, p<0.05 compared to the other phenotypes). Frequent exacerbator groups (FEE and FECB) were receiving more pharmacological treatment at baseline, and also experienced more exacerbations the year after (all p<0.05) with no differences in one-year mortality. Most of NE (93%) and half of exacerbators were stable after one year. There is an uneven distribution of COPD phenotypes in stable COPD patients, with significant differences in demographics, patient-centered outcomes and health care resources use.

Published
2016

48. The evaluation of a remote support program on quality of life and evolution of disease in COPD patients with frequent exacerbations

Author

Alcazar, Bernardino, primary, de Lucas, Pilar, additional, Soriano, Joan B., additional, Fernández-Nistal, Alonso, additional, Fuster, Antonia, additional, González-Moro, Jose Miguel Rodríguez, additional, Arnedillo, Aurelio, additional, Sidro, Patricia García, additional, and de los Monteros, María José Espinosa, additional

Published
2016
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49. The Effect of Supplemental Oxygen in Obesity Hypoventilation Syndrome

Author

Masa, Juan F., primary, Corral, Jaime, additional, Romero, Auxiliadora, additional, Caballero, Candela, additional, Terán-Santos, Joaquin, additional, Alonso-Álvarez, Maria L., additional, Gomez-Garcia, Teresa, additional, González, Mónica, additional, López-Martínez, Soledad, additional, De Lucas, Pilar, additional, Marin, José M., additional, Marti, Sergi, additional, Díaz-Cambriles, Trinidad, additional, Chiner, Eusebi, additional, Merchan, Miguel, additional, Egea, Carlos, additional, Obeso, Ana, additional, and Mokhlesi, Babak, additional

Published
2016
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50. Noninvasive ventilatin efficacy for obesity hypoventilation syndrome without severe sleep apnea

Author

Masa Jiménez, Juan Fernando, primary, Sánchez-Quiroga, M.-Ángeles, additional, Corral, Jaime, additional, Caballero, Candela, additional, Barrot, Emilia, additional, Terán-Santos, Joaquín, additional, Alonso-Álvarez, Maria L., additional, Gomez-Garcia, Teresa, additional, González, Mónica, additional, López-Martinez, Soledad, additional, De Lucas, Pilar, additional, Marin, José M., additional, Marti, Sergi, additional, Díaz-Cambriles, Trinidad, additional, Chiner, Eusebi, additional, Egea, Carlos, additional, Miranda, Erika, additional, and Mokhlesi, Babak, additional

Published
2016
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