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296 results on '"De Luca, Caterina"'

1. Non-Small Cell Lung Cancer Testing on Reference Specimens: An Italian Multicenter Experience

Author

Pepe, Francesco, Russo, Gianluca, Venuta, Alessandro, Scimone, Claudia, Nacchio, Mariantonia, Pisapia, Pasquale, Goteri, Gaia, Barbisan, Francesca, Chiappetta, Caterina, Pernazza, Angelina, Campagna, Domenico, Giordano, Marco, Perrone, Giuseppe, Sabarese, Giovanna, Altimari, Annalisa, de Biase, Dario, Tallini, Giovanni, Calistri, Daniele, Chiadini, Elisa, Capelli, Laura, Santinelli, Alfredo, Gulini, Anna Elisa, Pierpaoli, Elisa, Badiali, Manuela, Murru, Stefania, Murgia, Riccardo, Guerini Rocco, Elena, Venetis, Konstantinos, Fusco, Nicola, Morotti, Denise, Gianatti, Andrea, Furlan, Daniela, Rossi, Giulio, Melocchi, Laura, Russo, Maria, De Luca, Caterina, Palumbo, Lucia, Simonelli, Saverio, Maffè, Antonella, Francia di Celle, Paola, Venesio, Tiziana, Scatolini, Maria, Grosso, Enrico, Orecchia, Sara, Fassan, Matteo, Balistreri, Mariangela, Zulato, Elisabetta, Reghellin, Daniela, Lazzari, Elena, Santacatterina, Maria, Piredda, Maria Liliana, Riccardi, Manuela, Laurino, Licia, Roz, Elena, Longo, Domenico, Romeo, Daniela Petronilla, Fazzari, Carmine, Moreno-Manuel, Andrea, Puglia, Giuseppe Diego, Prjibelski, Andrey D., Shafranskaya, Daria, Righi, Luisella, Listì, Angela, Vitale, Domenico, Iaccarino, Antonino, Malapelle, Umberto, and Troncone, Giancarlo

Published
2024
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3. Tranexamic acid versus oxytocin prophylaxis in reducing post-partum blood loss, in low-risk pregnant women: TRANOXY STUDY, a phase III randomized clinical trial

Author

Ragusa, Antonio, Ficarola, Fernando, Ferrari, Amerigo, Spirito, Nicoletta, Ardovino, Mario, Giraldi, Domenico, Stuzziero, Elisario, Rinaldo, Denise, Procaccianti, Roberto, Larciprete, Giovanni, De Luca, Caterina, D'Avino, Sara, Principi, Giulia, Angioli, Roberto, and Svelato, Alessandro

Published
2024
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4. Shoulder Dystocia and Simulation

Author

Caporale, Nicola, Svelato, Alessandro, De Luca, Caterina, Zucchelli, Emma, D’Avino, Sara, Ragusa, Antonio, Cinnella, Gilda, editor, Beck, Renata, editor, and Malvasi, Antonio, editor

Published
2023
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9. Understanding EGFR heterogeneity in lung cancer

Author

Passaro, Antonio, Malapelle, Umberto, Del Re, Marzia, Attili, Ilaria, Russo, Alessandro, Guerini-Rocco, Elena, Fumagalli, Caterina, Pisapia, Pasquale, Pepe, Francesco, De Luca, Caterina, Cucchiara, Federico, Troncone, Giancarlo, Danesi, Romano, Spaggiari, Lorenzo, De Marinis, Filippo, and Rolfo, Christian

Published
2020
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11. Liquid biopsy for lung cancer: A cross section on the diagnostic routine experience of a referral Italian institution

Author

de Luca, Caterina, primary, Russo, Gianluca, additional, Nacchio, Mariantonia, additional, Ingenito, Maria, additional, Palumbo, Lucia, additional, Gragnano, Gianluca, additional, Conticelli, Floriana, additional, Russo, Maria, additional, Rocco, Danilo, additional, Gridelli, Cesare, additional, Bianco, Roberto, additional, Galetta, Domenico, additional, Troncone, Giancarlo, additional, Parente, Paola, additional, and Iaccarino, Antonino, additional

Published
2023
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12. Technical validation of a fully integrated NGS platform in real-world practice of Italian referral institution

Author

De Luca, Caterina, primary, Pepe, Francesco, additional, Russo, Gianluca, additional, Nacchio, Mariantonia, additional, Pisapia, Pasquale, additional, Russo, Maria, additional, Conticelli, Floriana, additional, Palumbo, Lucia, additional, Scimone, Claudia, additional, Cozzolino, Domencio, additional, Gragnano, Gianluca, additional, Iaccarino, Antonino, additional, Troncone, Giancarlo, additional, and Malapelle, Umberto, additional

Published
2023
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15. Technical Validation of a Fully Integrated NGS Platform in the Real-World Practice of Italian Referral Institutions.

Author

De Luca, Caterina, Pepe, Francesco, Russo, Gianluca, Nacchio, Mariantonia, Pisapia, Pasquale, Russo, Maria, Conticelli, Floriana, Palumbo, Lucia, Scimone, Claudia, Cozzolino, Domenico, Gragnano, Gianluca, Iaccarino, Antonino, Troncone, Giancarlo, and Malapelle, Umberto

Subjects
*MOLECULAR diagnosis, *DNA sequencing, *BIOMARKERS, *INDIVIDUALIZED medicine, *MOLECULAR pathology
Abstract

Aims: To date, precision medicine has played a pivotal role in the clinical administration of solid-tumor patients. In this scenario, a rapidly increasing number of predictive biomarkers have been approved in diagnostic practice or are currently being investigated in clinical trials. A pitfall in molecular testing is the diagnostic routine sample available to analyze predictive biomarkers; a scant tissue sample often represents the only diagnostical source of nucleic acids with which to conduct molecular analysis. At the sight of these critical issues, next-generation sequencing (NGS) platforms emerged as referral testing strategies for the molecular analysis of predictive biomarkers in routine practice, but the need for highly skilled personnel and extensive working time drastically impacts the widespread diffusion of this technology in diagnostic settings. Here, we technically validate a fully integrated NGS platform on diagnostic routine tissue samples previously tested with an NGS-based diagnostic workflow by a referral institution. Methods: A retrospective series of n = 64 samples (n = 32 DNA, n = 32 RNA samples), previously tested using a customized NGS assay (SiRe™ and SiRe fusion), was retrieved from the internal archive of the University of Naples Federico II. Each sample was tested by adopting an Oncomine Precision Assay (OPA), which is able to detect 2769 molecular actionable alterations [hotspot mutations, copy number variations (CNV) and gene fusions] on fully integrated NGS platforms (Genexus, Thermo Fisher Scientific (Waltham, MA, USA). The concordance rate between these technical approaches was determined. Results: The Genexus system successfully carried out molecular analysis in all instances. A concordance rate of 96.9% (31 out of 32) was observed between the OPA and SiRe™ panels both for DNA- and RNA-based analysis. A negative predictive value of 100% and a positive predictive value of 96.9% (62 out of 64) were assessed. Conclusions: A fully automatized Genexus system combined with OPA (Thermo Fisher Scientific) may be considered a technically valuable, time-saving sequencing platform to test predictive biomarkers in diagnostic routine practice. [ABSTRACT FROM AUTHOR]

Published
2023
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18. Plastic and Placenta: Identification of Polyethylene Glycol (PEG) Compounds in the Human Placenta by HPLC-MS/MS System

Author

Ragusa, Antonio, primary, Lelli, Veronica, additional, Fanelli, Giuseppina, additional, Svelato, Alessandro, additional, D’Avino, Sara, additional, Gevi, Federica, additional, Santacroce, Criselda, additional, Catalano, Piera, additional, Rongioletti, Mauro Ciro Antonio, additional, De Luca, Caterina, additional, Gulotta, Alessandra, additional, Rinalducci, Sara, additional, and Timperio, Anna Maria, additional

Published
2022
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19. Critical aspects of microsatellite instability testing in endometrial cancer: a comparison study

Author

Libera, Laura, primary, Sahnane, Nora, additional, Pepe, Francesco, additional, Pisapia, Pasquale, additional, De Luca, Caterina, additional, Russo, Gianluca, additional, Parente, Paola, additional, Covelli, Claudia, additional, Chiaravalli, Anna Maria, additional, Sessa, Fausto, additional, Malapelle, Umberto, additional, and Furlan, Daniela, additional

Published
2022
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20. Deeply in Plasticenta: Presence of Microplastics in the Intracellular Compartment of Human Placentas

Author

Ragusa, Antonio, primary, Matta, Maria, additional, Cristiano, Loredana, additional, Matassa, Roberto, additional, Battaglione, Ezio, additional, Svelato, Alessandro, additional, De Luca, Caterina, additional, D’Avino, Sara, additional, Gulotta, Alessandra, additional, Rongioletti, Mauro Ciro Antonio, additional, Catalano, Piera, additional, Santacroce, Criselda, additional, Notarstefano, Valentina, additional, Carnevali, Oliana, additional, Giorgini, Elisabetta, additional, Vizza, Enrico, additional, Familiari, Giuseppe, additional, and Nottola, Stefania Annarita, additional

Published
2022
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22. Critical aspects of MSI testing in endometrial cancer: a comparison study

Author

Libera, Laura, Sahnane, Nora, Pepe, Francesco, Pisapia, Pasquale, De Luca, Caterina, Russo, Gianluca, Parente, Paola, Covelli, Claudia, Chiaravalli, Anna Maria, Sessa, Fausto, Malapelle, Umberto, Furlan, Daniela, Libera, Laura, Sahnane, Nora, Pepe, Francesco, Pisapia, Pasquale, De Luca, Caterina, Russo, Gianluca, Parente, Paola, Covelli, Claudia, Chiaravalli, Anna Maria, Sessa, Fausto, Malapelle, Umberto, and Furlan, Daniela

Published
2022

23. MMR profile and microsatellite instability status in colorectal mucinous adenocarcinoma with synchronous metastasis: a new clue for the clinical practice.

Author

Parente, Paola, Malapelle, Umberto, Angerilli, Valentina, Balistreri, Mariangela, Lonardi, Sara, Pucciarelli, Salvatore, De Luca, Caterina, Pepe, Francesco, Russo, Gianluca, Vigliar, Elena, Danza, Angela, Scaramuzzi, Fabio, Troncone, Giancarlo, Graziano, Paolo, and Fassan, Matteo

Subjects
DNA mismatch repair, MUCINOUS adenocarcinoma, MICROSATELLITE repeats, METASTASIS
Published
2023
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25. Evaluation of the Molecular Landscape in PD-L1 Positive Metastatic NSCLC: Data from Campania, Italy

Author

Pisapia, Pasquale, primary, Iaccarino, Antonino, additional, De Luca, Caterina, additional, Acanfora, Gennaro, additional, Bellevicine, Claudio, additional, Bianco, Roberto, additional, Daniele, Bruno, additional, Ciampi, Luisa, additional, De Felice, Marco, additional, Fabozzi, Teresa, additional, Formisano, Luigi, additional, Giordano, Pasqualina, additional, Gridelli, Cesare, additional, Ianniello, Giovanni Pietro, additional, Libroia, Annamaria, additional, Maione, Paolo, additional, Nacchio, Mariantonia, additional, Pagni, Fabio, additional, Palmieri, Giovanna, additional, Pepe, Francesco, additional, Russo, Gianluca, additional, Salatiello, Maria, additional, Santaniello, Antonio, additional, Scamarcio, Rachele, additional, Seminati, Davide, additional, Troia, Michele, additional, Troncone, Giancarlo, additional, Vigliar, Elena, additional, and Malapelle, Umberto, additional

Published
2022
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27. Raman Microspectroscopy Detection and Characterisation of Microplastics in Human Breastmilk

Author

Ragusa, Antonio, primary, Notarstefano, Valentina, additional, Svelato, Alessandro, additional, Belloni, Alessia, additional, Gioacchini, Giorgia, additional, Blondeel, Christine, additional, Zucchelli, Emma, additional, De Luca, Caterina, additional, D’Avino, Sara, additional, Gulotta, Alessandra, additional, Carnevali, Oliana, additional, and Giorgini, Elisabetta, additional

Published
2022
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29. Evaluation of the Molecular Landscape in PD-L1 Positive Metastatic NSCLC: Data from Campania, Italy

Author

Pisapia, P, Iaccarino, A, De Luca, C, Acanfora, G, Bellevicine, C, Bianco, R, Daniele, B, Ciampi, L, De Felice, M, Fabozzi, T, Formisano, L, Giordano, P, Gridelli, C, Ianniello, G, Libroia, A, Maione, P, Nacchio, M, Pagni, F, Palmieri, G, Pepe, F, Russo, G, Salatiello, M, Santaniello, A, Scamarcio, R, Seminati, D, Troia, M, Troncone, G, Vigliar, E, Malapelle, U, Pisapia, Pasquale, Iaccarino, Antonino, De Luca, Caterina, Acanfora, Gennaro, Bellevicine, Claudio, Bianco, Roberto, Daniele, Bruno, Ciampi, Luisa, De Felice, Marco, Fabozzi, Teresa, Formisano, Luigi, Giordano, Pasqualina, Gridelli, Cesare, Ianniello, Giovanni Pietro, Libroia, Annamaria, Maione, Paolo, Nacchio, Mariantonia, Pagni, Fabio, Palmieri, Giovanna, Pepe, Francesco, Russo, Gianluca, Salatiello, Maria, Santaniello, Antonio, Scamarcio, Rachele, Seminati, Davide, Troia, Michele, Troncone, Giancarlo, Vigliar, Elena, Malapelle, Umberto, Pisapia, P, Iaccarino, A, De Luca, C, Acanfora, G, Bellevicine, C, Bianco, R, Daniele, B, Ciampi, L, De Felice, M, Fabozzi, T, Formisano, L, Giordano, P, Gridelli, C, Ianniello, G, Libroia, A, Maione, P, Nacchio, M, Pagni, F, Palmieri, G, Pepe, F, Russo, G, Salatiello, M, Santaniello, A, Scamarcio, R, Seminati, D, Troia, M, Troncone, G, Vigliar, E, Malapelle, U, Pisapia, Pasquale, Iaccarino, Antonino, De Luca, Caterina, Acanfora, Gennaro, Bellevicine, Claudio, Bianco, Roberto, Daniele, Bruno, Ciampi, Luisa, De Felice, Marco, Fabozzi, Teresa, Formisano, Luigi, Giordano, Pasqualina, Gridelli, Cesare, Ianniello, Giovanni Pietro, Libroia, Annamaria, Maione, Paolo, Nacchio, Mariantonia, Pagni, Fabio, Palmieri, Giovanna, Pepe, Francesco, Russo, Gianluca, Salatiello, Maria, Santaniello, Antonio, Scamarcio, Rachele, Seminati, Davide, Troia, Michele, Troncone, Giancarlo, Vigliar, Elena, and Malapelle, Umberto

Abstract

Background: Immune-checkpoint inhibitors (ICIs) have increased and improved the treatment options for patients with non-oncogene-addicted advanced stage non-small cell lung cancer (NSCLC). However, the role of ICIs in oncogene-addicted advanced stage NSCLC patients is still debated. In this study, in an attempt to fill in the informational gap on the effect of ICIs on other driver mutations, we set out to provide a molecular landscape of clinically relevant oncogenic drivers in programmed death-ligand 1 (PD-L1) positive NSCLC patients. Methods: We retrospectively reviewed data on 167 advanced stage NSCLC PD-L1 positive patients (≥1%) who were referred to our clinic for molecular evaluation of five driver oncogenes, namely, EGFR, KRAS, BRAF, ALK and ROS1. Results: Interestingly, n = 93 (55.7%) patients showed at least one genomic alteration within the tested genes. Furthermore, analyzing a subset of patients with PD-L1 tumor proportion score (TPS) ≥ 50% and concomitant gene alterations (n = 8), we found that n = 3 (37.5%) of these patients feature clinical benefit with ICIs administration, despite the presence of a concomitant KRAS gene alteration. Conclusions: In this study, we provide a molecular landscape of clinically relevant biomarkers in NSCLC PD-L1 positive patients, along with data evidencing the clinical benefit of ICIs in patient NSCLC PD-L1 positive alterations.

Published
2022

33. MMR profile and microsatellite instability status in colorectal mucinous adenocarcinoma with synchronous metastasis: a new clue for the clinical practice

Author

Parente, Paola, primary, Malapelle, Umberto, additional, Angerilli, Valentina, additional, Balistreri, Mariangela, additional, Lonardi, Sara, additional, Pucciarelli, Salvatore, additional, De Luca, Caterina, additional, Pepe, Francesco, additional, Russo, Gianluca, additional, Vigliar, Elena, additional, Danza, Angela, additional, Scaramuzzi, Fabio, additional, Troncone, Giancarlo, additional, Graziano, Paolo, additional, and Fassan, Matteo, additional

Published
2022
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38. Evaluation of Micro Satellite Instability and Mismatch Repair Status in Different Solid Tumors: A Multicenter Analysis in a Real World Setting

Author

Malapelle, Umberto, primary, Parente, Paola, additional, Pepe, Francesco, additional, De Luca, Caterina, additional, Pisapia, Pasquale, additional, Sgariglia, Roberta, additional, Nacchio, Mariantonia, additional, Gragnano, Gianluca, additional, Russo, Gianluca, additional, Conticelli, Floriana, additional, Bellevicine, Claudio, additional, Vigliar, Elena, additional, Iaccarino, Antonino, additional, Covelli, Claudia, additional, Balistreri, Mariangela, additional, Clemente, Celeste, additional, Perrone, Giovanni, additional, Danza, Angela, additional, Scaramuzzi, Fabio, additional, Fassan, Matteo, additional, Troncone, Giancarlo, additional, and Graziano, Paolo, additional

Published
2021
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41. RNA-Based Assay for Next-Generation Sequencing of Clinically Relevant Gene Fusions in Non-Small Cell Lung Cancer

Author

De Luca, C, Pepe, F, Iaccarino, A, Pisapia, P, Righi, L, Listì, A, Greco, L, Gragnano, G, Campione, S, De Dominicis, G, Pagni, F, Sgariglia, R, Nacchio, M, Tufano, R, Conticelli, F, Vigliar, E, Bellevicine, C, Cortinovis, D, Novello, S, Molina-Vila, M, Rosell, R, Troncone, G, Malapelle, U, De Luca, Caterina, Pepe, Francesco, Iaccarino, Antonino, Pisapia, Pasquale, Righi, Luisella, Listì, Angela, Greco, Lorenza, Gragnano, Gianluca, Campione, Severo, De Dominicis, Gianfranco, Pagni, Fabio, Sgariglia, Roberta, Nacchio, Mariantonia, Tufano, Rossella, Conticelli, Floriana, Vigliar, Elena, Bellevicine, Claudio, Cortinovis, Diego Luigi, Novello, Silvia, Molina-Vila, Miguel Angel, Rosell, Rafael, Troncone, Giancarlo, Malapelle, Umberto, De Luca, C, Pepe, F, Iaccarino, A, Pisapia, P, Righi, L, Listì, A, Greco, L, Gragnano, G, Campione, S, De Dominicis, G, Pagni, F, Sgariglia, R, Nacchio, M, Tufano, R, Conticelli, F, Vigliar, E, Bellevicine, C, Cortinovis, D, Novello, S, Molina-Vila, M, Rosell, R, Troncone, G, Malapelle, U, De Luca, Caterina, Pepe, Francesco, Iaccarino, Antonino, Pisapia, Pasquale, Righi, Luisella, Listì, Angela, Greco, Lorenza, Gragnano, Gianluca, Campione, Severo, De Dominicis, Gianfranco, Pagni, Fabio, Sgariglia, Roberta, Nacchio, Mariantonia, Tufano, Rossella, Conticelli, Floriana, Vigliar, Elena, Bellevicine, Claudio, Cortinovis, Diego Luigi, Novello, Silvia, Molina-Vila, Miguel Angel, Rosell, Rafael, Troncone, Giancarlo, and Malapelle, Umberto

Abstract

Gene fusions represent novel predictive biomarkers for advanced non-small cell lung cancer (NSCLC). In this study, we validated a narrow NGS gene panel able to cover therapeutically-relevant gene fusions and splicing events in advanced-stage NSCLC patients. To this aim, we first assessed minimal complementary DNA (cDNA) input and the limit of detection (LoD) in different cell lines. Then, to evaluate the feasibility of applying our panel to routine clinical samples, we retrospectively selected archived lung adenocarcinoma histological and cytological (cell blocks) samples. Overall, our SiRe RNA fusion panel was able to detect all fusions and a splicing event harbored in a RNA pool diluted up to 2 ng/µL. It also successfully analyzed 46 (95.8%) out of 48 samples. Among these, 43 (93.5%) out of 46 samples reproduced the same results as those obtained with conventional techniques. Intriguingly, the three discordant results were confirmed by a CE-IVD automated real-time polymerase chain reaction (RT-PCR) analysis (Easy PGX platform, Diatech Pharmacogenetics, Jesi, Italy). Based on these findings, we conclude that our new SiRe RNA fusion panel is a valid and robust tool for the detection of clinically relevant gene fusions and splicing events in advanced NSCLC.

Published
2021

44. PD‐L1 and beyond: Immuno‐oncology in cytopathology

Author

Iaccarino, Antonino, primary, Salatiello, Maria, additional, Migliatico, Ilaria, additional, De Luca, Caterina, additional, Gragnano, Gianluca, additional, Russo, Maria, additional, Bellevicine, Claudio, additional, Malapelle, Umberto, additional, Troncone, Giancarlo, additional, and Vigliar, Elena, additional

Published
2021
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46. Moving towards a local testing solution for undetermined thyroid fine-needle aspirates: validation of a novel custom DNA-based NGS panel.

Author

Sgariglia, Roberta, Nacchio, Mariantonia, Migliatico, Ilaria, Vigliar, Elena, Malapelle, Umberto, Pisapia, Pasquale, De Luca, Caterina, Iaccarino, Antonino, Salvatore, Domenico, Masone, Stefania, Troncone, Giancarlo, and Bellevicine, Claudio

Subjects
THYROID gland, BIOLOGICAL specimens, P53 antioncogene, BRAF genes, ANAPLASTIC thyroid cancer, PINE needles, MOLECULAR pathology
Published
2022
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48. Evaluation of a fully closed real time PCR platform for the detection of SARS-CoV-2 in nasopharyngeal swabs: a pilot study

Author

De Luca, Caterina, primary, Gragnano, Gianluca, additional, Conticelli, Floriana, additional, Cennamo, Michele, additional, Pisapia, Pasquale, additional, Terracciano, Daniela, additional, Malapelle, Umberto, additional, Montella, Emma, additional, Triassi, Maria, additional, Troncone, Giancarlo, additional, and Portella, Giuseppe, additional

Published
2021
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49. Moving towards a local testing solution for undetermined thyroid fine-needle aspirates: validation of a novel custom DNA-based NGS panel

Author

Sgariglia, Roberta, primary, Nacchio, Mariantonia, additional, Migliatico, Ilaria, additional, Vigliar, Elena, additional, Malapelle, Umberto, additional, Pisapia, Pasquale, additional, De Luca, Caterina, additional, Iaccarino, Antonino, additional, Salvatore, Domenico, additional, Masone, Stefania, additional, Troncone, Giancarlo, additional, and Bellevicine, Claudio, additional

Published
2021
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