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3. Social Life Cycle Assessment of Batteries

Author

Cellura, Maurizio, De Luca, Anna Irene, Iofrida, Nathalie, Mistretta, Marina, Passerini, Stefano, editor, Barelli, Linda, editor, Baumann, Manuel, editor, Peters, Jens, editor, and Weil, Marcel, editor

Published
2024
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4. Roadmap for optical tweezers

Author

Volpe, Giovanni, Maragò, Onofrio M, Rubinsztein-Dunlop, Halina, Pesce, Giuseppe, Stilgoe, Alexander B, Volpe, Giorgio, Tkachenko, Georgiy, Truong, Viet Giang, Chormaic, Síle Nic, Kalantarifard, Fatemeh, Elahi, Parviz, Käll, Mikael, Callegari, Agnese, Marqués, Manuel I, Neves, Antonio AR, Moreira, Wendel L, Fontes, Adriana, Cesar, Carlos L, Saija, Rosalba, Saidi, Abir, Beck, Paul, Eismann, Jörg S, Banzer, Peter, Fernandes, Thales FD, Pedaci, Francesco, Bowen, Warwick P, Vaippully, Rahul, Lokesh, Muruga, Roy, Basudev, Thalhammer-Thurner, Gregor, Ritsch-Marte, Monika, García, Laura Pérez, Arzola, Alejandro V, Castillo, Isaac Pérez, Argun, Aykut, Muenker, Till M, Vos, Bart E, Betz, Timo, Cristiani, Ilaria, Minzioni, Paolo, Reece, Peter J, Wang, Fan, McGloin, David, Ndukaife, Justus C, Quidant, Romain, Roberts, Reece P, Laplane, Cyril, Volz, Thomas, Gordon, Reuven, Hanstorp, Dag, Marmolejo, Javier Tello, Bruce, Graham D, Dholakia, Kishan, Li, Tongcang, Brzobohatý, Oto, Simpson, Stephen H, Zemánek, Pavel, Ritort, Felix, Roichman, Yael, Bobkova, Valeriia, Wittkowski, Raphael, Denz, Cornelia, Kumar, GV Pavan, Foti, Antonino, Donato, Maria Grazia, Gucciardi, Pietro G, Gardini, Lucia, Bianchi, Giulio, Kashchuk, Anatolii V, Capitanio, Marco, Paterson, Lynn, Jones, Philip H, Berg-Sørensen, Kirstine, Barooji, Younes F, Oddershede, Lene B, Pouladian, Pegah, Preece, Daryl, Adiels, Caroline Beck, De Luca, Anna Chiara, Magazzù, Alessandro, Ciriza, David Bronte, Iatì, Maria Antonia, and Swartzlander, Grover A

Subjects
Physical Sciences, Classical Physics, Nanotechnology, Bioengineering, optical tweezers, optical trapping, optical manipulation, Atomic, molecular and optical physics, Quantum physics
Abstract

Optical tweezers are tools made of light that enable contactless pushing, trapping, and manipulation of objects, ranging from atoms to space light sails. Since the pioneering work by Arthur Ashkin in the 1970s, optical tweezers have evolved into sophisticated instruments and have been employed in a broad range of applications in the life sciences, physics, and engineering. These include accurate force and torque measurement at the femtonewton level, microrheology of complex fluids, single micro- and nano-particle spectroscopy, single-cell analysis, and statistical-physics experiments. This roadmap provides insights into current investigations involving optical forces and optical tweezers from their theoretical foundations to designs and setups. It also offers perspectives for applications to a wide range of research fields, from biophysics to space exploration.

Published
2023

5. Roadmap for Optical Tweezers

Author

Volpe, Giovanni, Maragò, Onofrio M., Rubinzstein-Dunlop, Halina, Pesce, Giuseppe, Stilgoe, Alexander B., Volpe, Giorgio, Tkachenko, Georgiy, Truong, Viet Giang, Chormaic, Síle Nic, Kalantarifard, Fatemeh, Elahi, Parviz, Käll, Mikael, Callegari, Agnese, Marqués, Manuel I., Neves, Antonio A. R., Moreira, Wendel L., Fontes, Adriana, Cesar, Carlos L., Saija, Rosalba, Saidi, Abir, Beck, Paul, Eismann, Jörg S., Banzer, Peter, Fernandes, Thales F. D., Pedaci, Francesco, Bowen, Warwick P, Vaippully, Rahul, Lokesh, Muruga, Roy, Basudev, Thalhammer, Gregor, Ritsch-Marte, Monika, García, Laura Pérez, Arzola, Alejandro V., Castillo, Isaac Pérez, Argun, Aykut, Muenker, Till M., Vos, Bart E., Betz, Timo, Cristiani, Ilaria, Minzioni, Paolo, Reece, Peter J., Wang, Fan, McGloin, David, Ndukaife, Justus C., Quidant, Romain, Roberts, Reece P., Laplane, Cyril, Volz, Thomas, Gordon, Reuven, Hanstorp, Dag, Marmolejo, Javier Tello, Bruce, Graham D., Dholakia, Kishan, Li, Tongcang, Brzobohatý, Oto, Simpson, Stephen H., Zemánek, Pavel, Ritort, Felix, Roichman, Yael, Bobkova, Valeriia, Wittkowski, Raphael, Denz, Cornelia, Kumar, G. V. Pavan, Foti, Antonino, Donato, Maria Grazia, Gucciardi, Pietro G., Gardini, L., Bianchi, G., Kashchuk, A., Capitanio, M., Paterson, Lynn, Jones, P. H., Berg-Sørensen, Kirstine, Barooji, Younes F., Oddershede, Lene B., Pouladian, Pegah, Preece, Daryl, Adiels, Caroline Beck, De Luca, Anna Chiara, Magazzù, A., Ciriza, D. Bronte, Iatì, M. A., and Swartzlander, Grover A.

Subjects
Physics - Optics, Condensed Matter - Soft Condensed Matter
Abstract

Optical tweezers are tools made of light that enable contactless pushing, trapping, and manipulation of objects ranging from atoms to space light sails. Since the pioneering work by Arthur Ashkin in the 1970s, optical tweezers have evolved into sophisticated instruments and have been employed in a broad range of applications in life sciences, physics, and engineering. These include accurate force and torque measurement at the femtonewton level, microrheology of complex fluids, single micro- and nanoparticle spectroscopy, single-cell analysis, and statistical-physics experiments. This roadmap provides insights into current investigations involving optical forces and optical tweezers from their theoretical foundations to designs and setups. It also offers perspectives for applications to a wide range of research fields, from biophysics to space exploration., Comment: 181 pages, 61 figures

Published
2022

10. Raman and Surface Enhanced Raman spectroscopy analysis of breast cancer cell lines with different HER2 expression profiles

Author

Spaziani Sara, Esposito Alessandro, Barisciano Giovannina, Quero Giuseppe, Leo Manuela, Colantuoni Vittorio, Mangini Maria, Pisco Marco, Sabatino Lina, De Luca Anna Chiara, and Cusano Andrea

Subjects
Physics, QC1-999
Abstract

Assessing HER2 expression in breast cancer cells holds significant diagnostic and prognostic importance. Traditional methods like immunohistochemistry and in situ hybridization suffer from low sensitivity and misclassification rates. In this frame, techniques such as vibrational microscopies can ensure, together with low costs and analytical speed, both high accuracy and precision. Herein, we propose a combined Raman and SERS approach for characterizing 4 breast cancer cell lines and normal cells with varying HER2 expression levels. We show that Raman spectroscopy offers a promising alternative, providing unique molecular fingerprints for cell types based on their biochemical signatures. Its non-invasive nature and ability to detect subtle changes in cellular metabolism make it ideal for cancer cell analysis. Coupled with machine learning techniques like PCA and LDA, Raman spectroscopy can classify different breast cancer subcategories accurately. Surface Enhanced Raman Scattering (SERS) further enhances sensitivity, allowing the detection of single molecules like HER2 receptors. Overall, our results enable fast screening of cancer subpopulation in terms of HER2 concentration and macromolecule cell content. Integration of Raman spectroscopy with SERS offers precise identification and opens avenues for personalized therapies.

Published
2024
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11. Molecular Aptamer Beacon-based SERS biosensor for the detection of nucleic acids

Author

Martino Sara, Yilmaz Deniz, Esposito Alessandro, Giannetti Ambra, Misso Gabriella, Caraglia Michele, De Luca Anna Chiara, De Stefano Luca, and Rea Ilaria

Subjects
Physics, QC1-999
Abstract

Nucleic acids are essential biomolecules for the functioning of cells. In past years, nucleic acids have been assessing their role in prognostics and diagnostics. The progress of nanotechnology has allowed the fabrication of various type of nanostructured biosensors able to detect them with high sensitivity and specificity. Among the available sensing mechanisms, the sensor technology based on Surface-enhanced Raman Spectroscopy (SERS) is frequently preferred for identifying nucleic acids. In these sensors, natural or synthetic oligonucleotide sequences, acting as probes to hybridize the target molecules, are immobilized on a plasmonic sensing platform. In particular, aptamers, short DNA/RNA sequences, are emerging as new recognition elements for their chemical stability and specificity. Here, we focus on the combination of a specific type of aptamer, a molecular aptamer beacon, and nanostructured SERS biosensors for a sensitive detection of nucleic acids.

Published
2024
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12. Raman and Polarization-sensitive digital holographic imaging for rapid and label-free prostate cancer diagnosis

Author

Khadem Hossein, Ferrara Maria Antonietta, Mangini Maria, Luini Alberto, Coppola Giuseppe, and De Luca Anna Chiara

Subjects
Physics, QC1-999
Abstract

In this study, we report the results of two non-invasive optical methods, Raman microscopy (RM) and polarization-sensitive digital holographic imaging (PSDHI), for distinguishing prostate cancer cells from healthy ones. RM reveals cancer cells metabolize glucose faster, storing it as fatty acids and cholesteryl esters in lipid droplets (LDs). On the other hand, PSDHI shows significant morphological changes in LDs in glucose-incubated cancer cells, including number, volume, and refractive index. High birefringence in cancer LDs under perpendicular polarizations was observed, enabling fast discrimination with over 90% accuracy. PSDHI results align closely with Raman microscopy, suggesting its potential as a promising, high-speed technique for cancer screening purposes.

Published
2024
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13. Intracellular delivery, imaging and drug-sensing using a plasmonic-enhanced hybrid nanostystem

Author

Mangini Maria, Cave Donatella Delle, Tramontano Chiara, Corona Marco, De Stefano Luca, Rea Ilaria, De Luca Anna Chiara, and Lonardo Enza

Subjects
Physics, QC1-999
Abstract

Metastasis stands as the leading cause of mortality among colorectal cancer (CRC) patients. Galunisertib (LY2157299, LY) is a small molecule demonstrating promising anti-cancer effects by targeting the Transforming Growth Factor-beta (TGF-β) pathway. This route plays a pivotal role in initiating the epithelial-to-mesenchymal transition (EMT), a critical process for metastatic spread. Unfortunately, LY chronic treatment causes undesired effects. To mitigate these side effects, nanoscale drug delivery systems have emerged as a transformative approach in cancer treatment, enhancing drug effectiveness while minimizing toxicity. In this study, we introduce a hybrid nanosystem (DNP-AuNPs-LY@Gel) comprising porous diatomite nanoparticles decorated with plasmonic gold nanoparticles (AuNPs), encapsulating LY within a gelatin shell. This multifunctional nanosystem demonstrates efficient LY delivery, EMT reversal in CRC 2D and 3D cultures, and anti-cancer effects in vivo. Moreover, the nanosystem allowed the quantification with sub-femtogram resolution of the drug intracellularly released using surface-enhanced Raman spectroscopy (SERS). The release of LY is triggered by CRC cell acidic microenviroment. Real-time monitoring of drug release at the single-cell level is achieved by analyzing SERS signals of LY within CRC cells. The heightened efficacy of LY delivery through the DNP-AuNPs-LY@Gel complex offers a promising alternative strategy for reducing drug dosages and subsequent undesired effects.

Published
2024
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14. Raman Microscopy Identification of Secondary Spurious Phases in Molten GdSr2RuCu2O8-δ Superconductor for Photonics and Plasmonic Applications

Author

Gombos Marcello, Managò Stefano, Zola Danilo, Carapella Giovanni, Tarallo Oreste, Mocella Vito, De Luca Anna Chiara, Rendina Ivo, Ruffo Francesco, Orgiani Pasquale, and Ciancio Regina

Subjects
Physics, QC1-999
Abstract

Plasmonic and Photonics applications of superconducting materials, suggested at first by the necessity to minimize the dissipative losses of conventional metals in the high frequency ranges, are topics of growing interest in Optics. In this perspective, GdSr2RuCu2O8-δ (Gd1212) Rutheno-Cuprate Superconductor presents very promising properties, showing both superconducting and magnetically ordered phases coexisting in the same cell. To investigate its features, the fabrication of macroscopic crystallographically oriented samples is necessary. The use of melt texturing techniques has shown to be among the most effective ways to achieve the best characteristics, although the fabrication of high-quality Gd1212 samples is intrinsically difficult. To reach a better understanding of Gd1212 incongruent melting reaction, a series of bulk samples annealed at temperatures below and above the melting temperature was prepared. Raman Microscopy and Mapping performed on molten and re-solidified samples revealed the presence of different phases, corresponding to those identified in our previous studies. These observations were also confirmed by XRD, TGA-DTA, and SEM+EDS characterisations. Secondary phases formation showed a strong dependence on the temperature of the annealing treatments. Susceptibility and magnetization measurements show both superconducting and magnetic transitions and a contribution of different spurious magnetic phases as suggested by EDS.

Published
2024
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15. SERS-based biosensors for the detection of human Thyroglobulin in liquid biopsies

Author

Spaziani Sara, Quero Giuseppe, Managò Stefano, Zito Gianluigi, Terracciano Daniela, Macchia Paolo Emidio, Galeotti Francesco, Pisco Marco, De Luca Anna Chiara, and Cusano Andrea

Subjects
Physics, QC1-999
Abstract

Here we have developed an advanced surface-enhanced Raman scattering (SERS) platform that enables the ultrasensitive, rapid and highly specific identification of tumour biomarkers in liquid biopsies. Our focus is on the detection of Thyroglobulin (Tg), the most important tumour biomarker for the diagnosis and prognosis of thyroid cancer. Specifically, SERS-active substrates fabricated by nanosphere lithography on chip or on tips of optical fiber (OF) were functionalised with Tg Capture antibodies. Gold nanoparticles were functionalized with Detection antibodies and conjugated with a Raman reporter. The sandwich assay platform was validated in the planar configuration and a detection limit of only 7 pg/ml was successfully achieved. A careful morphological characterisation of the SERS substrates allowed us to strictly correlate the coverage area with the Tg concentration. The same approach was successfully demonstrated in the washout of fine needle aspiration biopsies from cancer patients. The strategy was transferred to the Lab On Fiber (LOF) SERS platform and successfully used to detect Tg concentration. The proposed SERS-enhanced immunoassay platform has proven to be highly versatile and can be used with both microfluidic chip POC devices and SERS-OF-based optrodes to perform sensitive, specific and rapid ex vivo assays for Tg detection in liquid intraoperative biopsies.

Published
2024
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16. Observation of spin-polarized directive coupling of light at bound states in the continuum

Author

Zito, Gianluigi, Romano, Silvia, Cabrini, Stefano, Calafiore, Giuseppe, De Luca, Anna Chiara, Penzo, Erika, and Mocella, Vito

Subjects
Atomic, Molecular and Optical Physics, Physical Sciences, Optical Physics, Electrical and Electronic Engineering, Communications Technologies, Atomic, molecular and optical physics
Abstract

Spin-polarized directive coupling of light associated with the photonic quantum spin-Hall effect (QSHE) is a nanoscale phenomenon based on strong spin–orbit interaction that has recently attracted significant attention. Herein, we discuss the experimental manifestation of QSHE intrinsic in the Bloch waves associated with a bound state in the continuum (BIC) of a dielectric photonic crystal metasurface (PhCM). We show numerically that BICs in nanoscale PhCMs have photonic spin angular momentum density transverse to the orbital momentum not only at the interfaces but also inside the confining dielectric medium. Then, we experimentally demonstrate that the fundamental Bloch waves of the BIC mode, macroscopically amplified on resonance, propagate along the symmetry axes of the PhCM obeying spin-momentum locking also at normal incidence, i.e., with no symmetry breaking. This BIC-enhanced spin-directive coupling of light may enable versatile implementations of spin-optical structures, paving the way for novel photonic spin multiplatform devices.

Published
2019

17. Quantum spin Hall effect in bound states in continuum

Author

Zito, Gianluigi, Romano, Silvia, Cabrini, Stefano, Calafiore, Giuseppe, De Luca, Anna Chiara, Penzo, Erika, and Mocella, Vito

Subjects
Quantum Physics, Physical Sciences, field enhancement, dielectric nanostructure, photonic crystal, fluorescence, Raman, sensing, bound states, physics.optics, Communications engineering, Electronics, sensors and digital hardware, Atomic, molecular and optical physics
Abstract

Moving the polarization of the incident wave along a meridian of the Poincaré sphere, experimentally we show that the coupling with the fundamental Bloch's surface waves of the mode, provide a spatially coherent, macroscopic spinmomentum locked propagation along the symmetry axes of the PhCM. This novel mechanism of light-spin manipulation enables a versatile implementation of spin-optical structures that may pave the way to novel strategies for light spin technology and photonic multiplatform implementations.

Published
2019

19. Quantum Spin-Hall Effect of Light at Bound States in the Continuum

Author

Zito, Gianluigi, Romano, Silvia, Cabrini, Stefano, Calafiore, Giuseppe, De Luca, Anna Chiara, Penzo, Erika, and Mocella, Vito

Subjects
Physics - Optics
Abstract

The discovery of the topological nature of free-space light and its quantum chiral behavior has recently raised large attention. This important scientific endeavor features spin-based integrated quantum technologies. Herein, we discuss a novel phenomenon based on a resonantly-enhanced quantum spin-Hall transport of light observed in a dielectric resonator operating near the bound-state-in-continuum (BIC) regime. The BIC mode is characterized by a transverse photonic spin angular momentum density extended on a macroscopic area. As such, the experimental excited mode in near-BIC regime generates resonant surface waves characterized by spin-momentum locking and that propagate along the symmetry axes of the structure. In addition, the generated side waves are interpreted as an abrupt nonparaxial redirection of the exciting far field light, which is responsible for the spin-to-orbital angular momentum conversion evidenced in the spin-orbit asymmetry measured in the intensity of the side waves. The experimental results are in excellent agreement with a model that combines geometric parallel transport of light polarization and spin-momentum locking. In addition, breaking the excitation symmetry leads to a total spin-directive coupling. Our results reveal the possibility of a BIC-enhanced macroscopic spin-directive coupling, a novel fundamental mechanism of light-spin manipulation that will have strong impact on emerging quantum technologies.

Published
2017

23. Riociguat treatment in patients with chronic thromboembolic pulmonary hypertension: Final safety data from the EXPERT registry

Author

Caneva, Jorge, Tuhay, Graciela, Diez, Mirta, Talavera, Maria Lujan, Acosta, Adriana, Vulcano, Norberto, Bosio, Martin, Maldonado, Lorena, Deleo, Sabino, Melatini, Luciano, Keogh, Anne, Kotlyar, Eugene, Feenstra, John, Dwyer, Nathan, Adams, Heath, Stevens, Wendy, Steele, Peter, Proudman, Susanna, Minson, Robert, Reeves, Glenn, Lavender, Melanie, Ng, Benjamin, Mackenzie, Michele, Barry, Lisa, Gruenberger, Margarethe, Huber, Charlotte, Lang, Irene, Tilea, Ioana, Sadushi-Kolici, Roela, Löffler-Ragg, Judith, Feistmantl, Lisa-Theresa, Evrard, Patrick, Louis, Renaud, Guiot, Julien, Naldi, Marco, De Pauw, Michel, Mehta, Sanjay, Camacho, Rafael Conde, Tovar, Patricia Parada, Londoño, Alejandro, Campo, Felipe, Garcia, Paula, Lema, Camila, Orozco-Levi, Mauricio, Martinez, William, Gomez, Juan Esteban, Nielsen-Kudsk, Jens Erik, Mellemkjaer, Soren, Anton, Ly, Altraja, Alan, Vihinen, Tapani, Vasankari, Tuija, Sitbon, Olivier, Cottin, Vincent, Têtu, Laurent, Noël-Savina, Elise, Shearman, Nicole, Tayler, Susanne, Olzik, Ilona, Kulka, Christine, Grimminger, Jan, Simon, Marcel, Nolde, Anna, Oqueka, Tim, Harbaum, Lars, Egenlauf, Benjamin, Ewert, Ralf, Schulz, Christian, Regotta, Sabine, Kramer, Tilmann, Knoop-Busch, Susanne, Gerhardt, Felix, Konstantinides, Stavros, Pitsiou, Georgia, Stanopoulos, Ioannis, Sourla, Evdokia, Mouratoglou, Sofia, Karvounis, Haralambos, Pappas, Athanasios, Georgopoulos, Dimitrios, Fanaridis, Michail, Mitrouska, Ioanna, Michalis, Lampros, Pappas, Konstantinos, Kotsia, Anna, Gaine, Sean, Vizza, Carmine Dario, Manzi, Giovanna, Poscia, Roberto, Badagliacca, Roberto, Agostoni, Piergiuseppe, Bruno, Noemi, Farina, Stefania, D'Alto, Michele, Argiento, Paola, Correra, Anna, Di Marco, Giovanni Maria, Cresci, Chiara, Vannucchi, Vieri, Torricelli, Elena, Garcea, Alessio, Pesci, Alberto, Sardella, Luca, Paciocco, Giuseppe, Pane, Federico, D'Armini, Andrea Maria, Pin, Maurizio, Grazioli, Valentina, Massola, Giulia, Sciortino, Antonio, Prediletto, Renato, Bauleo, Carolina, Airò, Edoardo, Ndreu, Rudina, Pavlickova, Ivana, Lunardi, Claudio, Mulè, Massimiliano, Farruggio, Silvia, Costa, Serena, Galgano, Giuseppe, Petruzzi, Mario, De Luca, Anna, Lombardi, Francesco, Roncon, Loris, Conte, Luca, Picariello, Claudio, Wirtz, Gil, Alexandre, Myriam, Vonk-Noordegraaf, A., Boogaard, H., Mager, J., Reesink, H., van den Toorn, Leon M., Boomars, Karin, Andreassen, Arne K., Castro, Graça, Tania, Gonçalves, Baptista, Rui, Marinho, António, Shiang, Teresa, Oliveira, Ana, Coutinho, Daniel, Sousa, Joana, Loureiro, Maria José, Repolho, Débora, Martins Jesus, Susana Maria, Capinha, Marta, Agostinho, João, Cardoso, Tania, Rocha, Andreia, Espinha, Mafalda, Ivanov, Kyundyul Ivanovich, Alexeeva, Dalyana Eduardovna, Batalina, Marina Vadimovna, Hegya, Daria Viktorovna, Zvereva, Tatyana Nikolaevna, Avdeev, Sergey Nikolaevich, Tsareva, Natalia Anatolievna, Galyavich, Albert Sarvatovich, Nikolaevich, Bykov Aleksander, Filippov, Evgeny Vladimirovich, Yakovleva, Olga Eduardovna, Pavlova, Olga Borisovna, Skripkina, Elena Sergeevna, Martynyuk, Tamila Vitalievna, Bukatova, Irina Fedorovna, Tregubova, Anna Viktorovna, Platonov, Dmitry Yurievich, Kolomeytseva, Tatyana Mikhaylovna, Al Dalaan, Abdullah, Abdelsayed, Abeer Abeer, Weheba, Ihab, Saleemi, Sarferaz, Sakkijha, Hussam, Bohacekova, Marcela, Valkovicova, Tatiana, Farkasova, Iveta, Quezada, Carlos Andres, Piccari, Lucilla, Blanco, Isabel, Sebastian, Laura, Roman, Antonio, Lopez, Manuel, Otero, Remedios, Elias, Teresa, Jara, Luis, Asencio, Isabel, Arjona, Josefa Jiménez, Almagro, Raúl Menor, Cárdenas, Salvador López, García, Salvador Alcaraz, Rodríguez, Patricia Villanueva, Lopez, Raquel, Garcia, Alberto, Avilés, Francisco Fernandez, De La Pava, Sebastian, Yotti, Raquel, Peñate, Gregorio Pérez, Marrero, Fernando León, Cifrián Martínez, José Manuel, Martinez-Meñaca, Amaya, Alonso, Lecue Pilar, Rozas, Sonia Fernandez, Fernandez, David Iturbe, Cuesta, Victor Mora, Söderberg, Stefan, Bartfay, Sven-Erik, Rundqvist, Bengt, Alfetlawi, Monthir, Wodlin, Peter, Schwarz, Esther Irene, Speich, Rudolf, Lador, Frédéric, Rochat, Thierry, Gasche-Soccal, Paola, Hsu, Chih-Hsin, Lin, Tsung-Hsien, Su, Ho-Ming, Lai, Wen-Ter, Chu, Chun Yuan, Hsu, Po-Chao, Voon, Wen-Chol, Yen, Hsueh-Wei, Yih-Jer Wu, Jacob, Wu, Shu-Hao, Huang, Wen-Pin, Fong, Man-Cai, Huang, Chien-Lung, Kuo, Ping-Hung, Lin, Yen-Hung, Lin, Jiunn-Lee, Hung, Chi-Sheng, Wu, Cho-Kai, Sung, Shih-Hsien, Huang, Wei-Chun, Cheng, Chin-Chang, Kuo, Shu-Hung, Wang, Wen-Hwa, Ho, Wan-Jing, Hsu, Tsu-Shiu, Mutlu, Bülent, Atas, Halil, Ongen, Gul, Un, Zeynep, Okumus, Gulfer, Hanta, Ismail, Corris, Paul, Peacock, Andrew, Church, Colin, Toshner, Mark, Newnham, Michael, Ghofrani, Hossein-Ardeschir, Gomez Sanchez, Miguel-Angel, Humbert, Marc, Pittrow, David, Simonneau, Gérald, Gall, Henning, Grünig, Ekkehard, Klose, Hans, Halank, Michael, Langleben, David, Snijder, Repke J., Escribano Subias, Pilar, Mielniczuk, Lisa M., Lange, Tobias J., Vachiéry, Jean-Luc, Wirtz, Hubert, Helmersen, Douglas S., Tsangaris, Iraklis, Barberá, Joan A., Pepke-Zaba, Joanna, Boonstra, Anco, Rosenkranz, Stephan, Ulrich, Silvia, Steringer-Mascherbauer, Regina, Delcroix, Marion, Jansa, Pavel, Šimková, Iveta, Giannakoulas, George, Klotsche, Jens, Williams, Evgenia, Meier, Christian, and Hoeper, Marius M.

Published
2021
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24. Riociguat treatment in patients with pulmonary arterial hypertension: Final safety data from the EXPERT registry

Author

Caneva, Jorge, Tuhay, Graciela, Diez, Mirta, Talavera, Maria Lujan, Acosta, Adriana, Vulcano, Norberto, Bosio, Martin, Maldonado, Lorena, Deleo, Sabino, Melatini, Luciano, Keogh, Anne, Kotlyar, Eugene, Feenstra, John, Dwyer, Nathan, Adams, Heath, Stevens, Wendy, Steele, Peter, Proudman, Susanna, Minson, Robert, Reeves, Glenn, Lavender, Melanie, Ng, Benjamin, Mackenzie, Michele, Barry, Lisa, Gruenberger, Margarethe, Huber, Charlotte, Lang, Irene, Tilea, Ioana, Sadushi-Kolici, Roela, Löffler-Ragg, Judith, Feistmantl, Lisa-Theresa, Evrard, Patrick, Guiot, Julien, Naldi, Marco, De Pauw, Michel, Louis, Renaud, Mehta, Sanjay, Camacho, Rafael Conde, Tovar, Patricia Parada, Londoño, Alejandro, Campo, Felipe, Garcia, Paula, Lema, Camila, Orozco-Levi, Mauricio, Martinez, William, Gomez, Juan Esteban, Nielsen-Kudsk, Jens Erik, Mellemkjaer, Soren, Anton, Ly, Altraja, Alan, Vihinen, Tapani, Vasankari, Tuija, Sitbon, Olivier, Cottin, Vincent, Têtu, Laurent, Noël-Savina, Elise, Shearman, Nicole, Tayler, Susanne, Olzik, Ilona, Kulka, Christine, Grimminger, Jan, Simon, Marcel, Nolde, Anna, Oqueka, Tim, Harbaum, Lars, Egenlauf, Benjamin, Ewert, Ralf, Schulz, Christian, Regotta, Sabine, Kramer, Tilmann, Knoop-Busch, Susanne, Gerhardt, Felix, Konstantinides, Stavros, Pitsiou, Georgia, Stanopoulos, Ioannis, Sourla, Evdokia, Mouratoglou, Sofia, Karvounis, Haralambos, Pappas, Athanasios, Mitrouska, Ioanna, Georgopoulos, Dimitrios, Fanaridis, Michail, Michalis, Lampros, Pappas, Konstantinos, Kotsia, Anna, Gaine, Sean, Vizza, Carmine Dario, Manzi, Giovanna, Poscia, Roberto, Badagliacca, Roberto, Agostoni, Piergiuseppe, Bruno, Noemi, Farina, Stefania, D'Alto, Michele, Argiento, Paola, Correra, Anna, Di Marco, Giovanni Maria, Cresci, Chiara, Vannucchi, Vieri, Torricelli, Elena, Garcea, Alessio, Pesci, Alberto, Sardella, Luca, Paciocco, Giuseppe, Pane, Federico, D'Armini, Andrea Maria, Pin, Maurizio, Grazioli, Valentina, Massola, Giulia, Sciortino, Antonio, Prediletto, Renato, Bauleo, Carolina, Airò, Edoardo, Ndreu, Rudina, Pavlickova, Ivana, Lunardi, Claudio, Farruggio, Silvia, Costa, Serena, Mulè, Massimiliano, Galgano, Giuseppe, Petruzzi, Mario, De Luca, Anna, Lombardi, Francesco, Roncon, Loris, Conte, Luca, Picariello, Claudio, Wirtz, Gil, Alexandre, Myriam, Vonk-Noordegraaf, A., Boogaard, H., Mager, J., Reesink, H., van den Toorn, Leon M., Boomars, Karin, Andreassen, Arne K., Castro, Graça, Tania, Gonçalves, Baptista, Rui, Marinho, António, Shiang, Teresa, Oliveira, Ana, Coutinho, Daniel, Sousa, Joana, Loureiro, Maria José, Repolho, Débora, Martins Jesus, Susana Maria, Capinha, Marta, Agostinho, João, Cardoso, Tania, Rocha, Andreia, Espinha, Mafalda, Ivanov, Kyundyul Ivanovich, Alexeeva, Dalyana Eduardovna, Batalina, Marina Vadimovna, Hegya, Daria Viktorovna, Zvereva, Tatyana Nikolaevna, Avdeev, Sergey Nikolaevich, Tsareva, Natalia Anatolievna, Galyavich, Albert Sarvatovich, Nikolaevich, Bykov Aleksander, Filippov, Evgeny Vladimirovich, Yakovleva, Olga Eduardovna, Pavlova, Olga Borisovna, Skripkina, Elena Sergeevna, Martynyuk, Tamila Vitalievna, Bukatova, Irina Fedorovna, Tregubova, Anna Viktorovna, Platonov, Dmitry Yurievich, Kolomeytseva, Tatyana Mikhaylovna, Al Dalaan, Abdullah, Abdelsayed, Abeer Abeer, Weheba, Ihab, Saleemi, Sarferaz, Sakkijha, Hussam, Bohacekova, Marcela, Valkovicova, Tatiana, Farkasova, Iveta, Quezada, Carlos Andres, Piccari, Lucilla, Blanco, Isabel, Sebastian, Laura, Roman, Antonio, Lopez, Manuel, Otero, Remedios, Elias, Teresa, Jara, Luis, Asencio, Isabel, Arjona, Josefa Jiménez, Almagro, Raúl Menor, Cárdenas, Salvador López, García, Salvador Alcaraz, Rodríguez, Patricia Villanueva, Lopez, Raquel, Garcia, Alberto, Avilés, Francisco Fernandez, De La Pava, Sebastian, Yotti, Raquel, Peñate, Gregorio Pérez, Marrero, Fernando León, Cifrián Martínez, José Manuel, Martinez-Meñaca, Amaya, Alonso, Lecue Pilar, Rozas, Sonia Fernandez, Fernandez, David Iturbe, Cuesta, Victor Mora, Söderberg, Stefan, Bartfay, Sven-Erik, Rundqvist, Bengt, Alfetlawi, Monthir, Wodlin, Peter, Schwarz, Esther Irene, Speich, Rudolf, Lador, Frédéric, Rochat, Thierry, Gasche-Soccal, Paola, Hsu, Chih-Hsin, Lin, Tsung-Hsien, Su, Ho-Ming, Lai, Wen-Ter, Chu, Chun Yuan, Hsu, Po-Chao, Voon, Wen-Chol, Yen, Hsueh-Wei, Yih-Jer Wu, Jacob, Wu, Shu-Hao, Huang, Wen-Pin, Fong, Man-Cai, Huang, Chien-Lung, Kuo, Ping-Hung, Lin, Yen-Hung, Lin, Jiunn-Lee, Hung, Chi-Sheng, Wu, Cho-Kai, Sung, Shih-Hsien, Huang, Wei-Chun, Cheng, Chin-Chang, Kuo, Shu-Hung, Wang, Wen-Hwa, Ho, Wan-Jing, Hsu, Tsu-Shiu, Mutlu, Bülent, Atas, Halil, Ongen, Gul, Un, Zeynep, Okumus, Gulfer, Hanta, Ismail, Corris, Paul, Peacock, Andrew, Church, Colin, Toshner, Mark, Newnham, Michael, Hoeper, Marius M., Gomez Sanchez, Miguel-Angel, Humbert, Marc, Pittrow, David, Simonneau, Gérald, Gall, Henning, Grünig, Ekkehard, Klose, Hans, Halank, Michael, Langleben, David, Snijder, Repke J., Escribano Subias, Pilar, Mielniczuk, Lisa M., Lange, Tobias J., Vachiéry, Jean-Luc, Wirtz, Hubert, Helmersen, Douglas S., Tsangaris, Iraklis, Barberà, Joan A., Pepke-Zaba, Joanna, Boonstra, Anco, Rosenkranz, Stephan, Ulrich, Silvia, Steringer-Mascherbauer, Regina, Delcroix, Marion, Jansa, Pavel, Šimková, Iveta, Giannakoulas, George, Klotsche, Jens, Williams, Evgenia, Meier, Christian, and Ghofrani, Hossein-Ardeschir

Published
2021
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25. Correlative Raman Imaging: Development and Cancer Applications.

Author

Khadem, Hossein, Mangini, Maria, Farazpour, Somayeh, and De Luca, Anna Chiara

Subjects
ATOMIC force microscopy, CELL morphology, FLUORESCENCE microscopy, ATOMIC spectroscopy, CONFOCAL microscopy
Abstract

Despite extensive research efforts, cancer continues to stand as one of the leading causes of death on a global scale. To gain profound insights into the intricate mechanisms underlying cancer onset and progression, it is imperative to possess methodologies that allow the study of cancer cells at the single-cell level, focusing on critical parameters such as cell morphology, metabolism, and molecular characteristics. These insights are essential for effectively discerning between healthy and cancerous cells and comprehending tumoral progression. Recent advancements in microscopy techniques have significantly advanced the study of cancer cells, with Raman microspectroscopy (RM) emerging as a particularly powerful tool. Indeed, RM can provide both biochemical and spatial details at the single-cell level without the need for labels or causing disruptions to cell integrity. Moreover, RM can be correlated with other microscopy techniques, creating a synergy that offers a spectrum of complementary insights into cancer cell morphology and biology. This review aims to explore the correlation between RM and other microscopy techniques such as confocal fluoresce microscopy (CFM), atomic force microscopy (AFM), digital holography microscopy (DHM), and mass spectrometry imaging (MSI). Each of these techniques has their own strengths, providing different perspectives and parameters about cancer cell features. The correlation between information from these various analysis methods is a valuable tool for physicians and researchers, aiding in the comprehension of cancer cell morphology and biology, unraveling mechanisms underlying cancer progression, and facilitating the development of early diagnosis and/or monitoring cancer progression. [ABSTRACT FROM AUTHOR]

Published
2024
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26. Inverse regulation of SOS1 and HKT1 protein localization and stability by SOS3/CBL4 in Arabidopsis thaliana

Author

Gámez-Arjona, Francisco, primary, Park, Hee Jin, additional, García, Elena, additional, Aman, Rashid, additional, Villalta, Irene, additional, Raddatz, Natalia, additional, Carranco, Raul, additional, Ali, Akhtar, additional, Ali, Zahir, additional, Zareen, Shah, additional, De Luca, Anna, additional, Leidi, Eduardo O., additional, Daniel-Mozo, Miguel, additional, Xu, Zheng-Yi, additional, Albert, Armando, additional, Kim, Woe-Yeon, additional, Pardo, Jose M., additional, Sánchez-Rodriguez, Clara, additional, Yun, Dae-Jin, additional, and Quintero, Francisco J., additional

Published
2024
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30. Optical eigenmode imaging

Author

De Luca, Anna Chiara, Kosmeier, Sebastian, Dholakia, Kishan, and Mazilu, Michael

Subjects
Physics - Optics
Abstract

We present an indirect imaging method that measures both amplitude and phase information from a transmissive target. Our method is based on an optical eigenmode decomposition of the light intensity and the first-order cross correlation between a target field and these eigenmodes. We demonstrate that such optical eigenmode imaging does not need any a priori knowledge of the imaging system and corresponds to a compressive full-field sampling leading to high image extraction efficiencies. Finally, we discuss the implications with respect to second-order correlation imaging.

Published
2011

31. Quantitative assessment of non-conservative radiation forces in an optical trap

Author

Pesce, Giuseppe, Volpe, Giorgio, De Luca, Anna Chiara, Rusciano, Giulia, and Volpe, Giovanni

Subjects
Condensed Matter - Statistical Mechanics
Abstract

The forces acting on an optically trapped particle are usually assumed to be conservative. However, the presence of a non-conservative component has recently been demonstrated. Here we propose a technique that permits one to quantify the contribution of such non-conservative component. This is an extension of a standard optical tweezers calibration technique and, therefore, can easily become a standard test to verify the conservative optical force assumption. Using this technique we have analyzed different-sized optically trapped particles under different trapping conditions. We conclude that the non-conservative effects are effectively negligible and do not affect the standard calibration procedure, unless for extremely low-power trapping, far away from the trapping regimes usually used in experiments., Comment: 8 pages, 4 figures; Europhys. Lett. (EPL) (2009), accepted

Published
2009
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36. Polarization Sensitive Digital Holographic Imaging in Biology

Author

Coppola Giuseppe, Mangini Maria, Zito Gianluigi, De Tommasi Edoardo, De Luca Anna Chiara, and Ferrara Maria Antonietta

Subjects
Physics, QC1-999
Abstract

A new, simple digital holography-based polarization microscope for quantitative birefringence imaging of biological cells is presented. As a proof of concept, two different class of cells have been characterized by polarization sensitive digital holographic imaging (PSDHI). These two cases study reported are: differentiation of leukaemia cells and identification of reacted sperm cells. Although further experimentation is necessary, the suggested approach could represent a prospective label-free diagnostic tool for use in biological and medical research and diagnosis.

Published
2022
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38. Application of Raman spectroscopy to the evaluation of F-actin changes in sea urchin eggs at fertilization.

Author

Mangini, Maria, Limatola, Nunzia, Ferrara, Maria Antonietta, Coppola, Giuseppe, Chun, Jong Tai, De Luca, Anna Chiara, and Santella, Luigia

Subjects
SEA urchins, RAMAN spectroscopy, F-actin, EGGS, CELL imaging
Abstract

Summary: The actin filaments on the surface of echinoderm oocytes and eggs readily undergo massive reorganization during meiotic maturation and fertilization. In sea urchin eggs, the actin cytoskeletal response to the fertilizing sperm is fast enough to accompany Ca2+ signals and to guide sperm's entry into the egg. Although recent work using live cell imaging technology confirmed changes in the actin polymerization status in fertilized eggs, as was previously shown using light and electron microscopy, it failed to provide experimental evidence of F-actin depolymerization a few seconds after insemination, which is concurrent with the sperm-induced Ca2+ release. In the present study, we applied Raman microspectroscopy to tackle this issue by examining the spectral profiles of the egg's subplasmalemmal regions before and after treating the eggs with actin drugs or fertilizing sperm. At both early (15 s) and late (15 min) time points after fertilization, specific peak shifts in the Raman spectra revealed change in the actin structure, and Raman imaging detected the cytoskeletal changes corresponding to the F-actin reorganization visualized with LifeAct-GFP in confocal microscopy. Our observation suggests that the application of Raman spectroscopy, which does not require microinjection of fluorescent probes and exogenous gene expression, may serve as an alternative or even advantageous method in disclosing rapid subtle changes in the subplasmalemmal actin cytoskeleton that are difficult to resolve. [ABSTRACT FROM AUTHOR]

Published
2024
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40. Life Cycle Assessment in the Fruit Sector

Author

Cerutti, Alessandro K., Beccaro, Gabriele L., Bosco, Simona, De Luca, Anna I., Falcone, Giacomo, Fiore, Angela, Iofrida, Nathalie, Lo Giudice, Agata, Strano, Alfio, Notarnicola, Bruno, editor, Salomone, Roberta, editor, Petti, Luigia, editor, Renzulli, Pietro A., editor, Roma, Rocco, editor, and Cerutti, Alessandro K., editor

Published
2015
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43. SERS optrode for human thyroglobulin detection in liquid biopsy

Author

Spaziani, Sara, primary, Quero, Giuseppe, additional, Managò, Stefano, additional, Zito, Gianluigi, additional, Terracciano, Daniela, additional, Macchia, Paolo E., additional, Galeotti, Francesco, additional, Pisco, Marco, additional, De Luca, Anna C., additional, and Cusano, Andrea, additional

Published
2023
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44. Roadmap for optical tweezers

Author

NASA Innovative Advanced Concepts, Australian Research Council, Japan Society for the Promotion of Science, Boğaziçi Üniversity, Novo Nordisk UK Research Foundation, Knut and Alice Wallenberg Foundation, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Universidad Autónoma de Madrid, Conselho Nacional de Desenvolvimento Científico e Tecnológico (Brasil), Universidade Federal do Ceará, Agenzia Spaziale Italiana, Istituto Nazionale di Astrofisica, Agence Nationale de la Recherche (France), Wellcome Trust, Austrian Science Fund, Universidad Nacional Autónoma de México, European Commission, European Research Council, German Research Foundation, Natural Sciences and Engineering Research Council of Canada, Swedish Research Council, Engineering and Physical Sciences Research Council (UK), Office of Naval Research (US), National Science Foundation (US), Institute of Geology of the Czech Academy of Sciences, Czech Science Foundation, Generalitat de Catalunya, University of Münster, Department of Science and Technology (India), Human Frontier Science Program, Biotechnology and Biological Sciences Research Council (UK), Medical Research Council (UK), Danish National Research Foundation, Independent Research Fund Denmark, Beckman Institute, Associazione Italiana per la Ricerca sul Cancro, Volpe, Giovanni [0000-0001-5057-1846], Maragò, Onofrio M. [0000-0002-7220-8527], Rubinsztein-Dunlop, Halina [0000-0002-8332-2309], Stilgoe, Alexander B. [0000-0002-9299-5695], Volpe, Giorgio [0000-0001-9993-5348], Truong, Viet Giang [0000-0003-3589-7850], Chormaic, Síle Nic [0000-0003-4276-2014], Elahi, Parviz [0000-0003-3545-8436], Käll, Mikael [0000-0002-1163-0345], Callegari, Agnese [0000-0002-4488-4106], Neves, Antonio A. R. [0000-0002-2615-8573], Eismann, Jörg S. [0000-0002-2495-4613], Banzer, Peter [0000-0002-6336-6953], Roy, Basudev [0000-0003-0737-2889], Thalhammer-Thurner, Gregor [0000-0002-3948-8045], Ritsch-Marte, Monika [0000-0002-5945-546X], Pérez Castillo, Isaac0000-0001-7622-9440, Muenker, Till M. [0000-0003-3225-8746], Vos, Bart E. [0000-0002-4325-6298], Betz, Timo [0000-0002-1548-0655], Reece, Peter J. [0000-0003-4852-3735], McGloin, David [0000-0002-0075-4481], Gordon, Reuven [0000-0002-1485-6067], Bruce, Graham D. [0000-0003-3403-0614], Dholakia, Kishan [0000-0001-6534-9009], Roichman, Yael [0000-0003-1927-4506], Bobkova, Valeriia [0000-0003-4080-9069], Wittkowski, Raphael [0000-0003-4881-9173], Denz, Cornelia [0000-0002-7292-2499], Pavan Kumar, G. V. [0000-0002-4036-7187], Foti, Antonino [0000-0002-9824-3099], Donato, Maria Grazia [0000-0002-7580-3137], Gucciardi, Pietro G. [0000-0003-1826-9174], Gardini, Lucia [0000-0003-0923-9221], Kashchuk, Anatolii V. [0000-0002-2364-9393], Capitanio, Marco [0000-0002-9799-9353], Paterson, Lynn [0000-0003-0493-5041], Jones, Philip H. [0000-0002-0860-631X], Berg-Sørensen, Kirstine [0000-0002-9977-3980], Oddershede, Lene B. [0000-0003-2923-2844], Magazzù, Alessandro [0000-0003-1247-2702], Bronte Ciriza, David [0000-0002-5874-6601], Iatì, Maria Antonia [0000-0002-3576-8656], Swartzlander, Grover A. [0000-0003-3513-2225], Volpe, Giovanni, Maragò, Onofrio M., Rubinsztein-Dunlop, Halina, Pesce, Giuseppe, Stilgoe, Alexander B., Volpe, Giorgio, Tkachenko, Georgiy, Truong, Viet Giang, Chormaic, Síle Nic, Kalantarifard, Fatemeh, Elahi, Parviz, Käll, Mikael, Callegari, Agnese, Marqués, Manuel I., Neves, Antonio A. R., Moreira, Wendel L., Fontes, Adriana, César, Carlos L., Saija, Rosalba, Saidi, Abir, Beck, Paul, Eismann, Jörg S., Banzer, Peter, Fernandes, Thales F. D., Pedaci, Francesco, Bowen, Warwick P., Vaippully, Rahul, Lokesh, Muruga, Roy, Basudev, Thalhammer-Thurner, Gregor, Ritsch-Marte, Monika, Pérez García, Laura, Arzola, Alejandro V., Pérez Castillo, Isaac, Argun, Aykut, Muenker, Till M., Vos, Bart E., Betz, Timo, Cristiani, Ilaria, Minzioni, Paolo, Reece, Peter J., Wang, Fan, McGloin, David, Ndukaife, Justus C., Quidant, Romain, Roberts, Reece P., Laplane, Cyril, Volz, Thomas, Gordon, Reuven, Hanstorp, Dag, Tello Marmolejo, Javier, Bruce, Graham D., Dholakia, Kishan, Li, Tongcang, Brzobohatý, Oto, Simpson, Stephen H., Zemánek, Pavel, Ritort, Félix, Roichman, Yael, Bobkova, Valeriia, Wittkowski, Raphael, Denz, Cornelia, Pavan Kumar, G. V., Foti, Antonino, Donato, Maria Grazia, Gucciardi, Pietro G., Gardini, Lucia, Bianchi, Giulio, Kashchuk, Anatolii V., Capitanio, Marco, Paterson, Lynn, Jones, Philip H., Berg-Sørensen, Kirstine, Barooji, Younes F., Oddershede, Lene B., Pouladian, Pegah, Preece, Daryl, Adiels, Caroline Beck, De Luca, Anna Chiara, Magazzù, Alessandro, Bronte Ciriza, David, Iatì, Maria Antonia, Swartzlander, Grover A., NASA Innovative Advanced Concepts, Australian Research Council, Japan Society for the Promotion of Science, Boğaziçi Üniversity, Novo Nordisk UK Research Foundation, Knut and Alice Wallenberg Foundation, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Universidad Autónoma de Madrid, Conselho Nacional de Desenvolvimento Científico e Tecnológico (Brasil), Universidade Federal do Ceará, Agenzia Spaziale Italiana, Istituto Nazionale di Astrofisica, Agence Nationale de la Recherche (France), Wellcome Trust, Austrian Science Fund, Universidad Nacional Autónoma de México, European Commission, European Research Council, German Research Foundation, Natural Sciences and Engineering Research Council of Canada, Swedish Research Council, Engineering and Physical Sciences Research Council (UK), Office of Naval Research (US), National Science Foundation (US), Institute of Geology of the Czech Academy of Sciences, Czech Science Foundation, Generalitat de Catalunya, University of Münster, Department of Science and Technology (India), Human Frontier Science Program, Biotechnology and Biological Sciences Research Council (UK), Medical Research Council (UK), Danish National Research Foundation, Independent Research Fund Denmark, Beckman Institute, Associazione Italiana per la Ricerca sul Cancro, Volpe, Giovanni [0000-0001-5057-1846], Maragò, Onofrio M. [0000-0002-7220-8527], Rubinsztein-Dunlop, Halina [0000-0002-8332-2309], Stilgoe, Alexander B. [0000-0002-9299-5695], Volpe, Giorgio [0000-0001-9993-5348], Truong, Viet Giang [0000-0003-3589-7850], Chormaic, Síle Nic [0000-0003-4276-2014], Elahi, Parviz [0000-0003-3545-8436], Käll, Mikael [0000-0002-1163-0345], Callegari, Agnese [0000-0002-4488-4106], Neves, Antonio A. R. [0000-0002-2615-8573], Eismann, Jörg S. [0000-0002-2495-4613], Banzer, Peter [0000-0002-6336-6953], Roy, Basudev [0000-0003-0737-2889], Thalhammer-Thurner, Gregor [0000-0002-3948-8045], Ritsch-Marte, Monika [0000-0002-5945-546X], Pérez Castillo, Isaac0000-0001-7622-9440, Muenker, Till M. [0000-0003-3225-8746], Vos, Bart E. [0000-0002-4325-6298], Betz, Timo [0000-0002-1548-0655], Reece, Peter J. [0000-0003-4852-3735], McGloin, David [0000-0002-0075-4481], Gordon, Reuven [0000-0002-1485-6067], Bruce, Graham D. [0000-0003-3403-0614], Dholakia, Kishan [0000-0001-6534-9009], Roichman, Yael [0000-0003-1927-4506], Bobkova, Valeriia [0000-0003-4080-9069], Wittkowski, Raphael [0000-0003-4881-9173], Denz, Cornelia [0000-0002-7292-2499], Pavan Kumar, G. V. [0000-0002-4036-7187], Foti, Antonino [0000-0002-9824-3099], Donato, Maria Grazia [0000-0002-7580-3137], Gucciardi, Pietro G. [0000-0003-1826-9174], Gardini, Lucia [0000-0003-0923-9221], Kashchuk, Anatolii V. [0000-0002-2364-9393], Capitanio, Marco [0000-0002-9799-9353], Paterson, Lynn [0000-0003-0493-5041], Jones, Philip H. [0000-0002-0860-631X], Berg-Sørensen, Kirstine [0000-0002-9977-3980], Oddershede, Lene B. [0000-0003-2923-2844], Magazzù, Alessandro [0000-0003-1247-2702], Bronte Ciriza, David [0000-0002-5874-6601], Iatì, Maria Antonia [0000-0002-3576-8656], Swartzlander, Grover A. [0000-0003-3513-2225], Volpe, Giovanni, Maragò, Onofrio M., Rubinsztein-Dunlop, Halina, Pesce, Giuseppe, Stilgoe, Alexander B., Volpe, Giorgio, Tkachenko, Georgiy, Truong, Viet Giang, Chormaic, Síle Nic, Kalantarifard, Fatemeh, Elahi, Parviz, Käll, Mikael, Callegari, Agnese, Marqués, Manuel I., Neves, Antonio A. R., Moreira, Wendel L., Fontes, Adriana, César, Carlos L., Saija, Rosalba, Saidi, Abir, Beck, Paul, Eismann, Jörg S., Banzer, Peter, Fernandes, Thales F. D., Pedaci, Francesco, Bowen, Warwick P., Vaippully, Rahul, Lokesh, Muruga, Roy, Basudev, Thalhammer-Thurner, Gregor, Ritsch-Marte, Monika, Pérez García, Laura, Arzola, Alejandro V., Pérez Castillo, Isaac, Argun, Aykut, Muenker, Till M., Vos, Bart E., Betz, Timo, Cristiani, Ilaria, Minzioni, Paolo, Reece, Peter J., Wang, Fan, McGloin, David, Ndukaife, Justus C., Quidant, Romain, Roberts, Reece P., Laplane, Cyril, Volz, Thomas, Gordon, Reuven, Hanstorp, Dag, Tello Marmolejo, Javier, Bruce, Graham D., Dholakia, Kishan, Li, Tongcang, Brzobohatý, Oto, Simpson, Stephen H., Zemánek, Pavel, Ritort, Félix, Roichman, Yael, Bobkova, Valeriia, Wittkowski, Raphael, Denz, Cornelia, Pavan Kumar, G. V., Foti, Antonino, Donato, Maria Grazia, Gucciardi, Pietro G., Gardini, Lucia, Bianchi, Giulio, Kashchuk, Anatolii V., Capitanio, Marco, Paterson, Lynn, Jones, Philip H., Berg-Sørensen, Kirstine, Barooji, Younes F., Oddershede, Lene B., Pouladian, Pegah, Preece, Daryl, Adiels, Caroline Beck, De Luca, Anna Chiara, Magazzù, Alessandro, Bronte Ciriza, David, Iatì, Maria Antonia, and Swartzlander, Grover A.

Abstract

Optical tweezers are tools made of light that enable contactless pushing, trapping, and manipulation of objects, ranging from atoms to space light sails. Since the pioneering work by Arthur Ashkin in the 1970s, optical tweezers have evolved into sophisticated instruments and have been employed in a broad range of applications in the life sciences, physics, and engineering. These include accurate force and torque measurement at the femtonewton level, microrheology of complex fluids, single micro- and nano-particle spectroscopy, single-cell analysis, and statistical-physics experiments. This roadmap provides insights into current investigations involving optical forces and optical tweezers from their theoretical foundations to designs and setups. It also offers perspectives for applications to a wide range of research fields, from biophysics to space exploration.

Published
2023

45. Raman Microscopy Identification of Secondary Spurious Phases in Molten GdSr2RuCu2O8-δ Superconductor for Photonics and Plasmonic Applications.

Author

Gombos, Marcello, Managò, Stefano, Zola, Danilo, Carapella, Giovanni, Tarallo, Oreste, Mocella, Vito, De Luca, Anna Chiara, Rendina, Ivo, Ruffo, Francesco, Orgiani, Pasquale, and Ciancio, Regina

Subjects
RAMAN spectroscopy, SUPERCONDUCTORS, PHOTONICS, PLASMONICS, X-ray diffraction
Abstract

Plasmonic and Photonics applications of superconducting materials, suggested at first by the necessity to minimize the dissipative losses of conventional metals in the high frequency ranges, are topics of growing interest in Optics. In this perspective, GdSr2RuCu2O8-δ (Gd1212) Rutheno-Cuprate Superconductor presents very promising properties, showing both superconducting and magnetically ordered phases coexisting in the same cell. To investigate its features, the fabrication of macroscopic crystallographically oriented samples is necessary. The use of melt texturing techniques has shown to be among the most effective ways to achieve the best characteristics, although the fabrication of high-quality Gd1212 samples is intrinsically difficult. To reach a better understanding of Gd1212 incongruent melting reaction, a series of bulk samples annealed at temperatures below and above the melting temperature was prepared. Raman Microscopy and Mapping performed on molten and re-solidified samples revealed the presence of different phases, corresponding to those identified in our previous studies. These observations were also confirmed by XRD, TGA-DTA, and SEM+EDS characterisations. Secondary phases formation showed a strong dependence on the temperature of the annealing treatments. Susceptibility and magnetization measurements show both superconducting and magnetic transitions and a contribution of different spurious magnetic phases as suggested by EDS. [ABSTRACT FROM AUTHOR]

Published
2024
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46. Intracellular SERS monitoring of drug release from plasmonic-assisted biosilica nanoparticles

Author

Tramontano Chiara, Managò Stefano, Delle Cave Donatella, Chianese Giovanna, Lonardo Enza, De Stefano Luca, De Luca Anna Chiara, and Rea Ilaria

Subjects
Physics, QC1-999
Abstract

Nanoscale delivery systems have been investigated for therapy due to their advantages, including the sustained delivery of drugs to cells and reduction of systemic toxicity compared to conventional treatments. However, their application is still hampered by experimental challenges, such as the investigation of the drug release in cells rather than in vitro. Here, we describe a hybrid nanoplatform for monitoring the drug release in living colorectal cancer (CRC) cells by Surface-Enhanced Raman Scattering (SERS). Specifically, the anticancer drug Galunisertib is encapsulated in diatomite nanoparticles (DNPs) decorated by gold nanoparticles (AuNPs) and capped by gelatin. The combination of DNP loading capacities with the Raman enhancement of Galunisertib provided by AuNPs enables bio-imaging and drug delivery without using fluorophores or markers, avoiding fluorescence-quenching issues. Thanks to the Raman enhancement of Galunisertib, the drug release profile is monitored and quantified in living cells by SERS with a femtogram scale resolution. When the gelatin shell is digested by proteases, Galunisertib is released and its SERS spectrum decreases, allowing real-time quantification in CRC cells. The therapeutic efficiency of the Galunisertib delivery platform offers an alternative route for lowering drug dose and toxicity.

Published
2021
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48. Contributors

Author

Achmon, Yigal, primary, Ancona, Valeria, additional, Bantle, Michael, additional, da Silva, Pedro D., additional, de Andrade, Luís P., additional, De Luca, Anna I., additional, Dhanjal, Daljeet Singh, additional, Falcone, Giacomo, additional, Fernández-Bayo, Jesús D., additional, Galanakis, Charis M., additional, Gaspar, Pedro D., additional, Greiner, Ralf, additional, Gulisano, Giovanni, additional, Gupta, Esha, additional, Hensel, Oliver, additional, Iofrida, Nathalie, additional, Kartal, Canan, additional, Koubaa, Mohamed, additional, Manning, Louise, additional, Nikmaram, Nooshin, additional, Nunes, José, additional, Otles, Semih, additional, Parniakov, Oleksii, additional, Roohinejad, Shahin, additional, Rosa, Marco D., additional, Sharma, Deepansh, additional, Shelef, Oren, additional, Sher, Yonatan, additional, Singh, Jaswinder, additional, Singh, Joginder, additional, Siracusa, Valentina, additional, Slinn, Heather, additional, Stillitano, Teodora, additional, Stoica, Maricica, additional, Strano, Alfio, additional, Sturm, Barbara, additional, von Gersdorff, Gardis J.E., additional, Vyas, Pratibha, additional, and Zocca, Renan O., additional

Published
2018
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